Usui Isao 薄井勲

… Alternative Names

USUI Isao 薄井勲

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Researcher Number	50377272
Other IDs
Affiliation (Current)	2025: 獨協医科大学, 医学部, 教授
Affiliation (based on the past Project Information) *help	2018 – 2025: 獨協医科大学, 医学部, 教授 2017: 獨協医科大学, 医学部, 准教授 2016: 富山大学, 附属病院, 講師 2011 – 2015: 富山大学, 大学病院, 講師 2010: 富山大学, 大学院・医学薬学研究部(医学), 助教 2005 – 2006: 富山大学, 附属病院, 助手
Review Section/Research Field	Principal Investigator Metabolomics / Basic Section 54040:Metabolism and endocrinology-related Except Principal Investigator Basic Section 54040:Metabolism and endocrinology-related / Metabolomics / Basic Section 58030:Hygiene and public health-related: excluding laboratory approach / Basic Section 52010:General internal medicine-related
Keywords	Principal Investigator 糖尿病 / マクロファージ / HIF-1a / 肥満 / 肝がん / 脂肪組織 / 褐色脂肪 / 脂肪細胞 / 脂肪組織褐色化 / 肝脂肪合成 … More / 脂肪肝 / 耐糖能異常 / 褐色化 / MAIT細胞 / 自然免疫型T細胞 / 3　マクロファージ / 2　肥満 / 1　肝がん / 肥満症 / マウス / 腫瘍関連マクロファージ / 肝細胞がん / HIF-1 / 低酸素 / インターロイキン10 / メタボリックシンドローム / 代謝学 / 内科系臨床医学 … More Except Principal Investigator インスリン抵抗性 / 糖代謝異常 / 肥満 / 腸内細菌叢 / 腸内細菌 / mTOR / JNK / IRS-1 / PPARgamma / Cre-loxP / 褐色脂肪細胞 / 白色脂肪細胞 / fragmented QRS / electrocardiogram / diastolic dysfucntion / heart failure / diabetes / 糖代謝 / 心筋リモデリング / 糖尿病性心不全 / CD-1db/dbマウス / CD-1ｄｂ/ｄｂマウス / GLP-1受容体作動薬 / SGLT2阻害薬 / 糖尿病性心筋症 / 代謝産物 / 糖尿病 / serine kinase / serine phosphorylation / insulin resistance / セリンキナーゼ / セリンリン酸化 Less

白色脂肪組織特異的なPparg欠損が全身の糖・脂質代謝に及ぼす影響についての検討
- Principal Investigator
  
  登丸琢也
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54040:Metabolism and endocrinology-related
- Research Institution
  Dokkyo Medical University
Elucidating the Heart Failure Formation Process as a Complication of Diabetes Mellitus by Electrocardiogram Machine Learning and Suppression by Advanced AI Clinical Practice
- Principal Investigator
  
  八木邦公
- Project Period (FY)
  2024 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 58030:Hygiene and public health-related: excluding laboratory approach
- Research Institution
  Kanazawa Medical University
糖尿病性心筋障害に対する糖尿病治療薬の影響に関する基礎的検討
- Principal Investigator
  
  城島輝雄
- Project Period (FY)
  2020 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52010:General internal medicine-related
- Research Institution
  Dokkyo Medical University
Regulation of glucose metabolism via microbial modification by dietary components
- Principal Investigator
  
  Fujisaka Shiho
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54040:Metabolism and endocrinology-related
- Research Institution
  University of Toyama
a study about the role of MAIT cells in the browning of white adipose tissue and the regulation of glucose metabolismPrincipal Investigator
- Principal Investigator
  
  Usui Isao
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54040:Metabolism and endocrinology-related
- Research Institution
  Dokkyo Medical University
Identification of gut microbiota- derived metabolites and the mechanisms that impair glucose metabolism
- Principal Investigator
  
  Fujisaka Shiho
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  University of Toyama
the effects of CD206-positive macrophages on obesity-associated liver tumorsPrincipal Investigator
- Principal Investigator
  
  USUI ISAO
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  Dokkyo Medical University
  University of Toyama
Effect of obesity and diabetes on liver cancer and tumor-associated macrophage polarizationPrincipal Investigator
- Principal Investigator
  
  USUI Isao
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  University of Toyama
Metabolic regulation by adipose tissue macrophage and interleulin-10Principal Investigator
- Principal Investigator
  
  USUI Isao
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  University of Toyama
MECHANISMS FOR INSULIN RESISTANCE BY SERINE KINASE ACTIVATION
- Principal Investigator
  
  KOBAYASHI Masashi
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  University of Toyama

[Book] 医学のあゆみ2016
- Author(s)
  薄井勲，戸邉一之
- Total Pages
  4
- Publisher
  医歯薬出版株式会社
- Data Source
  KAKENHI-PROJECT-25461333
[Book] 月刊糖尿病2015
- Author(s)
  瀧川章子，薄井勲，戸邉一之
- Total Pages
  8
- Publisher
  医学出版
- Data Source
  KAKENHI-PROJECT-25461333
[Book] 血管医学2014
- Author(s)
  薄井　勲、戸辺一之
- Total Pages
  8
- Publisher
  メディカルレビュー社
- Data Source
  KAKENHI-PROJECT-25461333
[Book] 医学のあゆみ2014
- Author(s)
  薄井　勲、戸辺一之
- Total Pages
  4
- Publisher
  医歯薬出版株式会社
- Data Source
  KAKENHI-PROJECT-25461333
[Book] Annual Review糖尿病・内分泌20142014
- Author(s)
  薄井　勲、戸辺一之
- Total Pages
  7
- Publisher
  中外医学社
- Data Source
  KAKENHI-PROJECT-25461333
[Book] 【自然免疫Update-研究最前線】自然免疫の関わる病態と治療への応用 M2マクロファージと疾患.医学のあゆみ2012
- Author(s)
  薄井勲、戸邉一之
- Publisher
  医歯薬出版
- Data Source
  KAKENHI-PROJECT-22590971
[Book] 最新臨床糖尿病学上-糖尿病学の最新動向-】糖尿病研究の進歩インスリン作用およびインスリン抵抗性発現機序インスリン抵抗性発現の分子機構インスリン抵抗性における炎症の役割.日本臨床2012
- Author(s)
  薄井勲、戸邉一之
- Publisher
  日本臨床社
- Data Source
  KAKENHI-PROJECT-22590971
[Book] 脂肪組織におけるマクロファージとインスリン抵抗性.Diabetes Journal2011
- Author(s)
  薄井勲、藤坂志帆,戸邉一之
- Publisher
  協和企画
- Data Source
  KAKENHI-PROJECT-22590971
[Book] 2型糖尿病のインスリン抵抗性における炎症の役割.日本臨床2011
- Author(s)
  薄井勲、戸邉一之
- Publisher
  日本臨床社
- Data Source
  KAKENHI-PROJECT-22590971
[Book] インスリン作用発現とその制御機構.日本臨床2011
- Author(s)
  薄井勲、戸邉一之
- Publisher
  日本臨床社
- Data Source
  KAKENHI-PROJECT-22590971
[Book] 脂肪組織でのインスリン作用とインスリン抵抗性.ホルモンと臨床2011
- Author(s)
  薄井勲、戸邉一之
- Publisher
  医学の世界社
- Data Source
  KAKENHI-PROJECT-22590971
[Journal Article] Impact of Vancomycin Treatment and Gut Microbiota on Bile Acid Metabolism and the Development of Non-Alcoholic Steatohepatitis in Mice2023
- Author(s)
  Kasai Kaichi、Igarashi Naoya、Tada Yuki、Kani Koudai、Takano Shun、Yanagibashi Tsutomu、Usui-Kawanishi Fumitake、Fujisaka Shiho、Watanabe Shiro、Ichimura-Shimizu Mayuko、Takatsu Kiyoshi、Tobe Kazuyuki、Tsuneyama Koichi、Furusawa Yukihiro、Nagai Yoshinori
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 24 Issue: 4 Pages: 4050-4050
- DOI
  10.3390/ijms24044050
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K05466, KAKENHI-PROJECT-22K07005, KAKENHI-PROJECT-20K08882, KAKENHI-PROJECT-20K19676
[Journal Article] Transcription of cytochrome P450 46A1 in NIH3T3 cells is negatively regulated by FBS2022
- Author(s)
  Shinohara Y, Ando H, Maekawa M, Arai M, Horibata Y, Satou M, Jojima T, Usui I, Aso Y, Sugimoto H.
- Journal Title
  
  Biochim Biopys Acta Mol Cell Biol Lipids
  
  Volume: 1867(6) Issue: 6 Pages: 159136-159136
- DOI
  10.1016/j.bbalip.2022.159136
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07314, KAKENHI-PROJECT-20K07329, KAKENHI-PROJECT-21K06824, KAKENHI-PROJECT-20K08893
[Journal Article] Increased Number of Mucosal-Associated Invariant T Cells Is Associated with the Inhibition of Nonalcoholic Fatty Liver Disease in High Fat Diet-Fed Mice.2022
- Author(s)
  Kishi H, Usui I, Jojima T, Fujisaka S, Wakamatsu S, Mizunuma-Inoue Y, Niitani T, Sakurai S, Iijima T, Tomaru T, Tobe K, Aso Y.
- Journal Title
  
  Int J Mol Sci.
  
  Volume: 23 Issue: 23 Pages: 15309-15309
- DOI
  10.3390/ijms232315309
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H03730, KAKENHI-PROJECT-20K08882, KAKENHI-PROJECT-20K08893
[Journal Article] Astaxanthin, a Marine Carotenoid, Maintains the Tolerance and Integrity of Adipose Tissue and Contributes to Its Healthy Functions.2021
- Author(s)
  Nawaz A, Nishida Y, Takikawa A, Fujisaka S, Kado T, Aminuddin A, Bilal M, Jeelani I, Rahil AM, Nishimura A, Kuwano T, Watanabe Y, Igarashi Y, Okabe K, Saeed A, Manzoor A, Usui I, Yagi K, Nakagawa T, Tobe K.
- Journal Title
  
  Nutrients
  
  Volume: 13 Issue: 12 Pages: 4374-4374
- DOI
  10.3390/nu13124374
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K10204, KAKENHI-PROJECT-20K22733, KAKENHI-PROJECT-20H03730, KAKENHI-PROJECT-20K08882, KAKENHI-PROJECT-21K10300, KAKENHI-PROJECT-20K20655
[Journal Article] Bofutsushosan improves gut barrier function with a bloom of Akkermansia muciniphila and improves glucose metabolism in mice with diet-induced obesity2020
- Author(s)
  Fujisaka Shiho、Usui Isao、Nawaz Allah、Igarashi Yoshiko、Okabe Keisuke、Furusawa Yukihiro、Watanabe Shiro、Yamamoto Seiji、Sasahara Masakiyo、Watanabe Yoshiyuki、Nagai Yoshinori、Yagi Kunimasa、Nakagawa Takashi、Tobe Kazuyuki
- Journal Title
  
  Scientific Reports
  
  Volume: 10 Issue: 1 Pages: 5544-5544
- DOI
  10.1038/s41598-020-62506-w
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18F18102, KAKENHI-PROJECT-17K08653, KAKENHI-PROJECT-17K09821, KAKENHI-PROJECT-18K10204, KAKENHI-PROJECT-17H04062, KAKENHI-PROJECT-18K07441, KAKENHI-PROJECT-18K08505
[Journal Article] Macrophage‐specific hypoxia‐inducible factor‐1α deletion suppresses the development of liver tumors in high‐fat diet‐fed obese and diabetic mice2019
- Author(s)
  Takikawa Akiko、Usui Isao、Fujisaka Shiho、Tsuneyama Koichi、Okabe Keisuke、Nakagawa Takashi、Nawaz Allah、Kado Tomonobu、Jojima Teruo、Aso Yoshimasa、Hayakawa Yoshihiro、Yagi Kunikimi、Tobe Kazuyuki
- Journal Title
  
  Journal of Diabetes Investigation
  
  Volume: in press Issue: 6 Pages: 1-8
- DOI
  10.1111/jdi.13047
- NAID
  120006980551
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07069, KAKENHI-PROJECT-18K16193, KAKENHI-PROJECT-16K09777, KAKENHI-PROJECT-17K16143, KAKENHI-PROJECT-18K08505, KAKENHI-PROJECT-18K10204, KAKENHI-PLANNED-17H06398
[Journal Article] Partial depletion of CD206-positive M2-like macrophages induces proliferation of beige progenitors and enhances browning after cold stimulation2018
- Author(s)
  Igarashi Yoshiko、Nawaz Allah、Kado Tomonobu、Bilal Muhammad、Kuwano Takahide、Yamamoto Seiji、Sasahara Masakiyo、Jiuxiang Xu、Inujima Akiko、Koizumi Keiichi、Imura Johji、Shibahara Naotoshi、Usui Isao、Fujisaka Shiho、Tobe Kazuyuki
- Journal Title
  
  Scientific Reports
  
  Volume: 8 Issue: 1 Pages: 14567-14567
- DOI
  10.1038/s41598-018-32803-6
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04062, KAKENHI-PROJECT-18F18102, KAKENHI-PROJECT-16K09777
[Journal Article] Ratio of low molecular weight serum adiponectin to the total adiponectin value is associated with type 2 diabetes through its relation to increasing insulin resistance.2018
- Author(s)
  Iwata M, Hara K, Kamura Y, Honoki H, Fujisaka S, Ishiki M, Usui I, Yagi K, Fukushima Y, Takano A, Kato H, Murakami S, Higuchi K, Kobashi C, Fukuda K, Koshimizu Y, Tobe K.
- Journal Title
  
  PLoS One
  
  Volume: 13 Issue: 3 Pages: e0192609-e0192609
- DOI
  10.1371/journal.pone.0192609
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09821, KAKENHI-PROJECT-18K08505, KAKENHI-PROJECT-18K10204
[Journal Article] Deletion of PHGDH in adipocytes improves glucose intolerance in diet-induced obese mice2018
- Author(s)
  Okabe Keisuke、Usui Isao、Yaku Keisuke、Hirabayashi Yoshio、Tobe Kazuyuki、Nakagawa Takashi
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 504 Issue: 1 Pages: 309-314
- DOI
  10.1016/j.bbrc.2018.08.180
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08653, KAKENHI-PROJECT-18K16193, KAKENHI-PROJECT-18K17921, KAKENHI-PROJECT-16K09777
[Journal Article] Overexpression of Nmnat3 efficiently increases NAD and NGD levels and ameliorates age-associated insulin resistance2018
- Author(s)
  Gulshan Maryam、Yaku Keisuke、Okabe Keisuke、Mahmood Arshad、Sasaki Tsutomu、Yamamoto Masashi、Hikosaka Keisuke、Usui Isao、Kitamura Tadahiro、Tobe Kazuyuki、Nakagawa Takashi
- Journal Title
  
  Aging Cell
  
  Volume: 17 Issue: 4
- DOI
  10.1111/acel.12798
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08653, KAKENHI-PROJECT-18K16193, KAKENHI-PROJECT-18K17921, KAKENHI-PROJECT-16K09777
[Journal Article] 肥満症における脂肪組織マクロファージのHIF-1aの重要性2017
- Author(s)
  薄井勲，戸邉一之
- Journal Title
  
  内分泌・糖尿病・代謝内科
  
  Volume: 44 Pages: 449-449
- Data Source
  KAKENHI-PROJECT-16K09777
[Journal Article] A subset of cerebrovascular pericytes originates from mature macrophages in the very early phase of vascular development in CNS.2017
- Author(s)
  S. Yamamoto, M. Muramatsu, E. Azuma, M. Ikutani, Y. Nagai, H. Sagara, B.N. Koo, S. Kita, E. O’Donnell, T. Osawa, H. Takahashi, K.I. Takano, M. Dohmoto, M. Sugimori, I. Usui, Y. Watanabe, N. Hatakeyama, T. Iwamoto, I. Komuro, K. Takatsu, K. Tobe, S. Niida, N. Matsuda, M. Shibuya, M. Sasahara
- Journal Title
  
  Sci Rep
  
  Volume: 7：3855 Issue: 1 Pages: 1-16
- DOI
  10.1038/s41598-017-03994-1
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08565, KAKENHI-PROJECT-16K09777, KAKENHI-PROJECT-17K15622, KAKENHI-PROJECT-26710005, KAKENHI-PUBLICLY-16H01567, KAKENHI-PROJECT-17H04062, KAKENHI-PROJECT-15K08527, KAKENHI-PROJECT-16K14605
[Journal Article] CD206+ M2-like macrophages regulate systemic glucose metabolism by inhibiting proliferation of adipocyte progenitors2017
- Author(s)
  Nawaz Allah, , Usui Isao, , et al
- Journal Title
  
  Nature Communications
  
  Volume: 8 Issue: 1 Pages: 286-301
- DOI
  10.1038/s41467-017-00231-1
- NAID
  120006535075
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09777, KAKENHI-PROJECT-17K08653, KAKENHI-PROJECT-17K09821, KAKENHI-PROJECT-15H05789, KAKENHI-PROJECT-15H04851, KAKENHI-PROJECT-17H04062, KAKENHI-PROJECT-15K08527
[Journal Article] Deletion of SIRT1 in myeloid cells impairs glucose metabolism with enhancing inflammatory response to adipose tissue hypoxia2016
- Author(s)
  Akiko Takikawa, Isao Usui , Shiho Fujisaka, Masashi Ikutani, Satoko Senda, Shinpei Hattori, Koichi Tsuneyama, Yukiko Koshimizu, Ran Inoue, Ayumi Tanaka-Hayashi, Takashi Nakagawa, Yoshinori Nagai, Kiyoshi Takatsu, Toshiyasu Sasaoka, Hisashi Mori, Kazuyuki Tobe
- Journal Title
  
  Diabetology International
  
  Volume: 7 Issue: 1 Pages: 59-68
- DOI
  10.1007/s13340-015-0213-3
- NAID
  40020774323
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08527, KAKENHI-PROJECT-25461333, KAKENHI-PROJECT-24689019, KAKENHI-PROJECT-26461327
[Journal Article] M2 macrophages in metabolism.2016
- Author(s)
  1)Fujisaka S, Usui I, Nawaz A, Takikawa A, Kado T, Igarashi Y, Tobe K.
- Journal Title
  
  Diabetes Int.
  
  Volume: 7 Pages: 342-351
- NAID
  40021041341
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K09777
[Journal Article] HIF-1α in Myeloid Cells Promotes Adipose Tissue Remodeling Toward Insulin Resistance.2016
- Author(s)
  Takikawa A, Mahmood A, Nawaz A, Kado T, Okabe K, Yamamoto S, Arif A, Senda S, Tsuneyama K, Ikutani M, Watanabe Y, Igarashi Y, Nagai Y, Takatsu K, Koizumi K, Imura J, Goda N, Sasahara M, Matsumoto M, Saeki K, Nakagawa T, Fujisaka S, Usui I, Tobe K.
- Journal Title
  
  Diabetes
  
  Volume: 65(12) Issue: 12 Pages: 3649-3659
- DOI
  10.2337/db16-0012
- NAID
  40021380120
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25293093, KAKENHI-PROJECT-26460360, KAKENHI-PROJECT-26461327, KAKENHI-PROJECT-15K08527, KAKENHI-PROJECT-16K09777, KAKENHI-PROJECT-16K19532
[Journal Article] Sirtuin 1 activator SRT1720 suppresses inflammation in an ovalbumin-induced mouse model of asthma.2013
- Author(s)
  Ichikawa T, Hayashi R, Suzuki K, Imanishi S, Kambara K, Okazawa S, Inomata M, Yamada T, Yamazaki Y, Koshimizu Y, Miwa T, Matsui S, Usui I, Urakaze M, Matsuya Y, Sasahara M, Tobe K.
- Journal Title
  
  Respirology
  
  Volume: １８ Issue: 2 Pages: 332-339
- DOI
  10.1111/j.1440-1843.2012.02284.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591158, KAKENHI-PROJECT-25293093, KAKENHI-PROJECT-25461333
[Journal Article] Adipose tissue hypoxia induces inflammatory M1 polarity of macrophages in an HIF-1α-dependent and HIF-1α-independent manner in obese mice.2013
- Author(s)
  Fujisaka S, Usui I, Ikutani M, Aminuddin A, Takikawa A, Tsuneyama K, Mahmood A, Goda N, Nagai Y, Takatsu K, Tobe K.
- Journal Title
  
  Diabetologia
  
  Volume: 56(6) Pages: 1403-12
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590971
[Journal Article] PACAP Attenuates NMDA-Induced Retinal Damage in Association with Modulation of the Microglia/Macrophage Status into an Acquired Deactivation Subtype.2013
- Author(s)
  Wada Y, Nakamachi T, Endo K, Seki T, Ohtaki H, Tsuchikawa D, Hori M, Tsuchida M, Yoshikawa A, Matkovits A, Kagami N, Imai N, Fujisaka S, Usui I, Tobe K, Koide R, Takahashi H, Shioda S
- Journal Title
  
  J Mol Neurosci.
  
  Volume: 51(2) Issue: 2 Pages: 493-502
- DOI
  10.1007/s12031-013-0017-5
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23249079, KAKENHI-PROJECT-24592680, KAKENHI-PROJECT-24592681, KAKENHI-PROJECT-25461333, KAKENHI-PROJECT-25462236
[Journal Article] Adipose Tissue Hypoxia Induces Inflammatory M1 Polarity of Macrophages in HIF-1a-Dependent and HIF-1a-Independent Manners in Obese Mice.2013
- Author(s)
  Fujisaka S, Usui I, Ikutani M, Aminuddin A, Takikawa A, Tsuneyama K, Mahmood A, Goda N, Nagai Y, Takatsu K, Tobe K..
- Journal Title
  
  Diabetologia
  
  Volume: 56(6) Issue: 6 Pages: 1403-1412
- DOI
  10.1007/s00125-013-2885-1
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590370, KAKENHI-PUBLICLY-24117708, KAKENHI-PROJECT-24390119, KAKENHI-PROJECT-24390181, KAKENHI-PROJECT-24590577, KAKENHI-PUBLICLY-25126707, KAKENHI-PROJECT-25461333
[Journal Article] Impact of divergent effects of astaxanthin on insulin signaling in L6 cells2013
- Author(s)
  Ishiki M, Nishida Y, Ishibashi H, Wada T, Fujisaka S, Takikawa A, Urakaze M, Sasaoka T, Usui I, Tobe K.
- Journal Title
  
  Endocrinology
  
  Volume: 154(8) Issue: 8 Pages: 2600-2612
- DOI
  10.1210/en.2012-2198
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25461333
[Journal Article] The Radioprotective 105/MD-1 complex contributes to diet-induced obesity and adipose tissue inflammation2012
- Author(s)
  Watanabe Y., Nakamura T., Ishikawa S., Fujisaka S., Usui I., Tsuneyama K., Ichihara Y., Wada T., Hirata Y., Suganami T., Izaki H., Akira S., Miyake K., Kanayama H., Shimabukuro M., Sata M., Sasaoka T.,Ogawa Y., Tobe K., Takatsu K., and Nagai Y.
- Journal Title
  
  Diabetes.
  
  Volume: 61(5) Pages: 1199-209
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590971
[Journal Article] Tobe K. SRT1720, a SIRT1 activator pomotes tumor cell migration, and lung metasiasis of breast cancer in mice2012
- Author(s)
  Suzuki K
- Journal Title
  
  Oncol Rep
  
  Volume: 27 Pages: 1726-1732
- DOI
  10.3892/or.2012.1750
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590669, KAKENHI-PROJECT-22590971, KAKENHI-PROJECT-24659348
[Journal Article] The Radioprotective 105/MD-1 complex contributes to diet-induced obesity and adipose tissue inflammation2012
- Author(s)
  Y. Watanabe, T. Nakamura, S. Ishikawa, S. Fujisaka, I. Usui, K. Tsuneyama, Y. Ichihara, T. Wada, Y. Hirata, T. Suganami, H. Izaki, S. Akira, K. Miyake, H. Kanayama, M. Shimabukuro, M. Sata, T. Sasaoka, Y. Ogawa, K. Tobe, K. Takatsu, Y. Nagai
- Journal Title
  
  Diabetes
  
  Volume: 61 Issue: 5 Pages: 1199-1209
- DOI
  10.2337/db11-1182
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-21117007, KAKENHI-PUBLICLY-22117509, KAKENHI-PROJECT-22390159, KAKENHI-PROJECT-22590971, KAKENHI-PROJECT-23591314, KAKENHI-PROJECT-23659247, KAKENHI-PROJECT-23659420, KAKENHI-PROJECT-24659392, KAKENHI-PLANNED-21117002, KAKENHI-PUBLICLY-24117708
[Journal Article] Telmisartan improves insulin resistance and modulates adipose tissue macrophage polarization in high-fat-fed mice2011
- Author(s)
  Fujisaka S., Usui I., Kanatani Y., Ikutani M., Takasaki I., Tsuneyama K., Tabuchi Y., Bukhari A., Yamazaki Y., Suzuki H., Senda S., Aminuddin A., Nagai Y., Takatsu K., Kobayashi M., To be K.
- Journal Title
  
  Endocrinology
  
  Volume: 152(5) Pages: 1789-99
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590971
[Journal Article] Deletion of platelet-derived growth factor receptor-βimproves diabetic nephropathy in Ca2+/calmodulin-dependent protein kinase II α (Thr286 Asp) transgenic mice2011
- Author(s)
  Suzuki H., Usui I., Kato I., Oya T., Kanatani Y., Yamazaki Y., Fujisaka S., Senda S., Ishii Y., Urakaze M., Mahmood A., Takasawa S., Okamoto H., Kobayashi M., To be K., Sasahara M
- Journal Title
  
  Diabetologia
  
  Volume: 54 Pages: 2953-2962
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590971
[Journal Article] Telmisartan Improves Insulin Resistance and Modulates Adipose Tissue Macrophage Polarization in High-Fat-Fed Mice.2011
- Author(s)
  Fujisaka S, Usui I, Kanatani Y, Ikutani M, Takasaki I, Tsuneyama K, Tabuchi Y, Bukhari A, Yamazaki Y, Suzuki H, Senda S, Aminuddin A, Nagai Y, Takatsu K, Kobayashi M, Tobe K.
- Journal Title
  
  Endochnology
  
  Volume: 152(5) Pages: 1789-1799
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590971
[Journal Article] Tumor necrosis factor-alpha accelerates apoptosis of steatotic hepatocytes from amurine model of non-alcoholic fatty liver disease.2010
- Author(s)
  Zhang W, Kudo H, Kawai K, Fujisaka S, Usui I, Sugiyama T, Tsukada K, Chen N, Takahara T.
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 391(4) Pages: 1731-1736
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590971
[Journal Article] Tranlocation of IRS-1 to Cytosol Attenuates Insulin-Stimulated Glucose Transport without Affecting PI3-Kinase Activity2010
- Author(s)
  Junko Kawahara, Isao Usui, Tetsuro Haruta, Yukiko Kanatani, Kazuyuki Hiratani, Atsuko Takano, Tatsuhito Uno, Minoru Iwata, Masashi Kobayashi, Kazuyuki Tobe
- Journal Title
  
  The Open Diabctcs Journal
  
  Volume: 3 Pages: 14-21
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590971
[Journal Article] Effects of Pioglitazone on SOCS3 Expression : Potential Mechanisms for Its Effects on Insulin Sensitivity and Adiponectin Expression.2007
- Author(s)
  Kanatani Y., Usui I., Ishizuka K., Bukhari A., Fujisaka S., Urakaze M., Haruta T., Kishimoto T., Naka T., Kobayashi M
- Journal Title
  
  Diabetes 56(3)
  
  Pages: 795-803
- Data Source
  KAKENHI-PROJECT-17590918
[Journal Article] Effects of Pioglitazone on SOCS3 Expression : Potential Mechanisms for Its Effects on Insulin Sensitivity and Adiponectin Expression.2007
- Author(s)
  Kanatani Y., Usui I., Ishizuka K., Bukhari A., Fujisaka S., Urakaze M., Haruta T., Kishimoto T., Naka T., Kobayashi M.
- Journal Title
  
  Diabetes 56(3)
  
  Pages: 795-803
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590918
[Journal Article] Chronic TNF {alpha} Treatment Causes Insulin Resistance via IRS-1 Serine Phosphorylation and SOCS3 Induction in 3T3-L1 Adipocytes.2007
- Author(s)
  Ishizuka K, Usui I, Kanatani Y, Bukhari A, He J, Fujisaka S, Yamazaki Y, Suzuki H, Hiratani K, Ishiki M, Iwata M, Urakaze Haruta T, Kobayashi M
- Journal Title
  
  Endocrinology
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590918
[Journal Article] Chronic TNF {alpha} Treatment Causes Insulin Resistance via IRS-1 Serine Phosphorylation and SOCS3 Induction in 3T3-L1 Adipocytes.2007
- Author(s)
  Ishizuka K, Usui I, Kanatani Y, Bukhari A, He J, Fujisaka S, Yamazald Y, Suzuki H, Hiratani K, Ishiki M, Iwata M, Urakaze M, Haruta T, Kobayashi M.
- Journal Title
  
  Endocrinology. (In press)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590918
[Journal Article] Interleukin-1 {alpha} Inhibit Insulin Signaling with Phosphoylating Insulin Receptor Substrate-1 on Serine Residues in 3T3-L1 Adipocytes2006
- Author(s)
  He J, Usui I, Ishizuka K, Kanatani Y, Hiratani K, Iwata M, Bukhari A, Haruta T, Sasaoka T, Kobayashi M
- Journal Title
  
  Molecular Endocrinology 20(1)
  
  Pages: 114-124
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590918
[Journal Article] Interleukin- 1 {alpha} Inhibits Insulin Signaling with Phosphorylating Insulin Receptor Substrate-1 on Serine Residues in 3T3-L1 Adipocytes2006
- Author(s)
  He J, Usui I, Ishizuka K, Kanatani Y, Hiratani K, Iwata M, Bukhari A, Haruta T, Sasaoka T, Kobayashi M
- Journal Title
  
  Molecular Endocrinology 20・1
  
  Pages: 114-124
- Data Source
  KAKENHI-PROJECT-17590918
[Journal Article] Interleukin-1 {alpha} Inhibits Insulin Signaling with Phosphorylating Insulin Receptor Substrate-1 on Serine Residues in 3T3-L1 Adipocytes2006
- Author(s)
  He J, Usui I, Ishizuka K, Kanatani Y, Hiratani K, Iwata M, Bukhari A, Haruta T, Sasaoka T, Kobayashi M
- Journal Title
  
  Molecular Endocrinology 20・1
  
  Pages: 114-124
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590918
[Journal Article] Roles of mTOR and JNK in serine phosphorylatian, translocatian, and degradation of IRS-1.2005
- Author(s)
  Hiratani K, Haruta T, Tani A, Kawahara J, Usui I, Kobayashi M
- Journal Title
  
  Biochem Biophys Res Cammun 335・3
  
  Pages: 836-842
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590918
[Journal Article] Roles of mTOR and JNK in serine phosphorylation, translocation, and degradation of IRS-1.2005
- Author(s)
  Hiratani K, Haruta T, Tani A Kawahara J, Usui I, Kobayashi M.
- Journal Title
  
  Biochem Biophys Res Commun. 335・33
  
  Pages: 836-842
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590918
[Journal Article] Roles of mTOR and JNK in serine phosphorylation, translocation, and degradation of IRS-1.2005
- Author(s)
  Hiratani K, Haruta T, Tani A Kawahara J, Usui I, Kobayashi M.
- Journal Title
  
  Biochem Biophys Res Commun. 335・3
  
  Pages: 836-842
- Data Source
  KAKENHI-PROJECT-17590918
[Presentation] MAIT細胞数の増加は高脂肪食飼育マウスの肝脂肪蓄積を抑制する2023
- Author(s)
  岸　遼、薄井　勲、城島　輝雄、若松　翔、井上　有威子、二井谷　隆文、櫻井　慎太郎、飯嶋　寿江、登丸　琢也、麻生　好正
- Organizer
  第６６回　日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-20K08893
[Presentation] 防風通聖散は腸内細菌Akkermansia muciniphilaを増加させ、高脂肪食負荷マウスの糖代謝を改善する．2018
- Author(s)
  藤坂志帆，薄井　勲，ナワズアラー，五十嵐喜子，角　朝信，古澤之裕，八木邦公，戸邉一之．
- Organizer
  第91回日本内分泌学会学術総会
- Data Source
  KAKENHI-PROJECT-16K09777
[Presentation] Bofutsushosan improved gut barrier function with a bloom of Akkermansia muciniphila and improves glucose metabolism in diet-induced obese mice2018
- Author(s)
  Shiho Fujisaka, Isao Usui, Allah Nawaz, Yoshiko Igarashi, Tomonobu Kado, Okabe Keisuke, Kunimasa Yagi, Takashi Nakagawa, Kazuyuki Tobe
- Organizer
  78th Scientific Sessions of American Diabetes Association
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09821
[Presentation] Bofutsushosan improved gut barrier function with a bloom of Akkermansia muciniphila and improves glucose metabolism in diet-induced obese mice.2018
- Author(s)
  Fujisaka S, Usui I, Nawaz A, Igarashi Y, Kado T, Okabe K, Yagi K, Nakagawa T, Tobe K.
- Organizer
  78th Scientific Sessions of American Diabetes Association;
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09777
[Presentation] NAD合成酵素Namptは代謝リプログラミングを介して前駆脂肪細胞分化を制御する2018
- Author(s)
  岡部圭介，西田康宏，Allah Nawaz，藤坂志帆，八木邦公，角　朝信，五十嵐喜子，薄井　勲，中川　崇，戸邉一之
- Organizer
  第39回日本肥満学会
- Data Source
  KAKENHI-PROJECT-16K09777
[Presentation] NAD合成酵素Namptは代謝リプログラミングを介して前駆脂肪細胞分化を制御する2018
- Author(s)
  岡部圭介，薄井　勲，西田康宏，Allah Nawaz，藤坂志帆，瀧川章子，角　朝信，五十嵐喜子，中川　崇，戸邉一之
- Organizer
  第61回日本糖尿病学会年次学術集会（若手研究奨励賞）
- Data Source
  KAKENHI-PROJECT-16K09777
[Presentation] 防風通聖散による腸内細菌叢と介した糖代謝改善作用2018
- Author(s)
  藤坂志帆，薄井　勲，Nawaz Allah，五十嵐喜子，角　朝信，岡部圭介，八木邦公，中川　崇，戸邉一之．
- Organizer
  第39回日本肥満学会
- Data Source
  KAKENHI-PROJECT-16K09777
[Presentation] 防風通聖散は腸内細菌Akkermansia muciniphilaを増加させ、高脂肪食負荷マウスの糖代謝を改善する2018
- Author(s)
  藤坂　志帆、薄井　勲、Allah Nawaz、五十嵐　喜子、角　朝信、古澤　之裕、八木邦公、戸邉　一之
- Organizer
  第91回日本内分泌学会学術総会
- Data Source
  KAKENHI-PROJECT-17K09821
[Presentation] 防風通聖散による腸内細菌叢を介した糖代謝改善作用2018
- Author(s)
  藤坂志帆，薄井　勲，Nawaz Allah，五十嵐喜子，角　朝信，岡部圭介，古澤之裕，八木邦公，戸邉一之．
- Organizer
  第61回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-16K09777
[Presentation] Bofutsushosan, an Oriental Herbal Medicine, induces Akkermansia muciniphila and improves glucose metabolism in diet-induced obese mice.2017
- Author(s)
  Shiho Fujisaka, Isao Usui, Yukihiro Furusawa, Allah Nawaz, Yoshiko Igarashi, Tomonobu Kado, Kazuyuki Tobe
- Organizer
  77th Scientific Sessions of American Diabetes Association
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09821
[Presentation] 防風通聖散は腸内細菌Akkermansia muciniphilaを増加させ、高脂肪食負荷マウスの耐糖能を改善する2017
- Author(s)
  藤坂志帆、薄井　勲、古澤　之裕、Allah Nawaz、五十嵐喜子、角　朝信、戸邉　一之
- Organizer
  第22回日本肥満学会アディポサイエンス・シンポジウム
- Data Source
  KAKENHI-PROJECT-17K09821
[Presentation] 脂肪組織病的肥大におけるマクロファージ由来Hif-1αの役割．2017
- Author(s)
  角　朝信，瀧川章子，Arshad M，Nawaz A，岡部圭介，藤坂志帆，中川　崇，常山幸一，薄井　勲，戸邉一之
- Organizer
  第38回日本肥満学会
- Data Source
  KAKENHI-PROJECT-16K09777
[Presentation] 肥満症・糖尿病に伴う肝がん発症におけるマクロファージHIF-1aの働き2017
- Author(s)
  瀧川章子，薄井　勲，張　群，岡部圭介，角　朝信，Allah Nawaz，藤坂志帆，中川　崇，常山幸一，戸邉一之
- Organizer
  第60回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-16K09777
[Presentation] HIF-1a in Myeloid Cells Promotes Adipose Tissue Remodeling Toward Insulin Resistance.2017
- Author(s)
  Tobe K., Takikawa A., Nawaz A., Kado T., Fujisaka S., Usui I.
- Organizer
  Keystone Symposia
- Place of Presentation
  Keystone
- Year and Date
  2017-01-22
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09777
[Presentation] 脂肪細胞分化におけるNAD代謝の役割2017
- Author(s)
  岡部圭介，薄井　勲，戸邉一之
- Organizer
  第38回日本肥満学会
- Data Source
  KAKENHI-PROJECT-16K09777
[Presentation] Nampt-mediated NAD synthesis regulates the metabolic remodeling during the differentiation of 3T3-L1 pre-adipocytes.2016
- Author(s)
  Okabe K., Usui I., Tobe K., Nakagawa T.
- Organizer
  76th Scientific Sessions of the American Diabetes Association
- Place of Presentation
  New Orleans
- Year and Date
  2016-06-10
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09777
[Presentation] Myeloid cell-specific HIF-1a deletion decreases the number of liver tumors in high fat-fed mice.2016
- Author(s)
  Takikawa A., Usui I., Zhang Q., Okabe K., Kado T., Nawaz A., Fujisaka S., Nakagawa T., Tsuneyama K., Tobe K.
- Organizer
  76th Scientific Sessions of the American Diabetes Association
- Place of Presentation
  New Orleans
- Year and Date
  2016-06-10
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09777
[Presentation] マクロファージ特異的HIF-1α欠損による食餌性肥満マウスの糖代謝・脂肪組織への影響2015
- Author(s)
  4.瀧川章子，Arshad Mahmood，Allah Nawaz，角朝信，山本誠士，常山幸一，岡部圭介，仙田聡子，中川崇，薄井勲，合田亘人，戸辺一之
- Organizer
  第58回日本糖尿病学会年次学術集会
- Place of Presentation
  下関市
- Year and Date
  2015-05-21
- Data Source
  KAKENHI-PROJECT-25461333
[Presentation] Myeloid Cell-specific HIF-1 alpha Deletion Protected against Insulin Resistance with Increased Angiogenesis in High Fat-fed Mice2015
- Author(s)
  Takikawa A, Mahmood A, Nawaz A, Kado T, Senda S, Okabe K, Usui I, Tobe K.
- Organizer
  the American Diabetes Association's 75th Scientific Sessions
- Place of Presentation
  米国　ボストン市
- Year and Date
  2015-06-05
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25461333
[Presentation] マクロファージSIRT1による糖代謝制御2015
- Author(s)
  薄井勲，瀧川章子,　戸辺一之
- Organizer
  第58回日本糖尿病学会年次学術集会
- Place of Presentation
  下関市
- Year and Date
  2015-05-21
- Invited
- Data Source
  KAKENHI-PROJECT-25461333
[Presentation] マクロファージ特異的HIF-1α欠損は高脂肪食負荷マウスの糖代謝を改善する2015
- Author(s)
  3.瀧川章子，Arshad Mahmood，Allah Nawaz，角朝信，仙田聡子，薄井勲，合田亘人，戸辺一之
- Organizer
  第88回日本内分泌学会学術総会
- Place of Presentation
  東京
- Year and Date
  2015-04-23
- Data Source
  KAKENHI-PROJECT-25461333
[Presentation] 肥満における脂肪組織マクロファージの機能2015
- Author(s)
  薄井勲，瀧川章子,　戸辺一之
- Organizer
  第36回日本肥満学会総会
- Place of Presentation
  名古屋市
- Year and Date
  2015-10-02
- Invited
- Data Source
  KAKENHI-PROJECT-25461333
[Presentation] 骨髄球特異的なHif-1α遺伝子の欠損は糖代謝を改善する2013
- Author(s)
  マハムドアルシャド, 薄井勲, 仙田聡子, 藤坂志帆, 瀧川章子, Aminuddin, 中川崇, 戸邉一之
- Organizer
  第56回日本糖尿病学会年次学術集会
- Place of Presentation
  熊本
- Invited
- Data Source
  KAKENHI-PROJECT-25461333
[Presentation] Myeloid cell-specific deletion of SIRT1 enhanced inflammatory response to hypoxia with glucose intolerance2013
- Author(s)
  Akiko Takikawa, Isao Usui, Satoko Senda, Shiho Fujisaka, Yukiko Koshimizu, Koichi Tsuneyama, Amiuddin, Arshad Mahmood, Masashi Ikutani, Yoshinori Nagai, Kiyoshi Takatsu, Hisashi Mori, Kazuyuki Tobe
- Organizer
  The American Diabetes Association's 73rd Scientific Sessions
- Place of Presentation
  Chicago
- Invited
- Data Source
  KAKENHI-PROJECT-25461333
[Presentation] Depletion of Cd206-positive cells is associated with increased WAT proliferation and improved insulin sensitivity.2013
- Author(s)
  Aminuddin, Shiho Fujisaka, Hisashi Mori, Kenji Kohno, Isao Usui, Kazuyuki Tobe.
- Organizer
  第56回日本糖尿病学会年次学術集会
- Place of Presentation
  熊本
- Invited
- Data Source
  KAKENHI-PROJECT-25461333
[Presentation] 脂肪組織低酸素とインスリン抵抗性2013
- Author(s)
  薄井勲、藤坂志帆、瀧川章子、Arshad Mahmood、戸邉一之
- Organizer
  第56回日本糖尿病学会年次学術集会
- Place of Presentation
  熊本
- Year and Date
  2013-05-17
- Data Source
  KAKENHI-PROJECT-22590971
[Presentation] Adipose Tissue Hypoxia Induces Inflammatory M1 Polarity of Macrophages in HIF-1a　-Dependent and HIF-1a　Independent Manners in Obese Mice.2013
- Author(s)
  Fujisaka S, Usui I, Ikutani M, Aminuddin A, Takikawa A, Tsuneyama K, Mahmood A, Goda N, Nagai Y, Takatsu K, and Tobe K
- Organizer
  The American Diabetes Association's 73rd Scientific Sessions
- Place of Presentation
  Chicago
- Invited
- Data Source
  KAKENHI-PROJECT-25461333
[Presentation] Depletion of CD206-positive cells is associated with increased WAT proliferation and improved insulin sensitivity2013
- Author(s)
  Aminuddin A., Fujisaka S., Mori H., Kohno K., Usui I., To be K..
- Organizer
  第56回日本糖尿病学会年次学術集会
- Place of Presentation
  熊本
- Year and Date
  2013-05-17
- Data Source
  KAKENHI-PROJECT-22590971
[Presentation] 脂肪組織低酸素とインスリン抵抗性2013
- Author(s)
  薄井勲、藤坂志帆, 瀧川章子、Arshad Mahmood、戸辺一之
- Organizer
  第56回日本糖尿病学会年次学術集会
- Place of Presentation
  熊本
- Invited
- Data Source
  KAKENHI-PROJECT-25461333
[Presentation] 慢性炎症とインスリン抵抗性脂肪組織マクロファージとSIRT1　（シンポジウム）2012
- Author(s)
  薄井　勲，藤坂志帆，瀧川章子，金谷由紀子，戸邉一之
- Organizer
  第55回日本糖尿病学会年次学術集会
- Place of Presentation
  パシフィコ横浜（神奈川県）
- Data Source
  KAKENHI-PROJECT-22590971
[Presentation] Impact of Adipose Tissue Hypoxia on Macriphage Polarization in Diet-induced Obese Mice2012
- Author(s)
  Fujisaka S., Usui I., Ikutani M., Aminuddin A., Senda S., Takikawa A., Ishiki M., Koshimizu Y., Tsuneyama K., Nagai Y., Takatsu K., Tobe K.
- Organizer
  American Diabetes Association 72nd Scientific Sessions
- Place of Presentation
  Philadelphia(USA)
- Data Source
  KAKENHI-PROJECT-22590971
[Presentation] Myeloid Cell-specific Deletion of SIRT1 Impairs Glucose Metabolism wiht Enhanced Inflammatory Response to Hypoxia2012
- Author(s)
  Takikawa A., Usui I., Senda S., Fujisaka S., Hattori S., Tsuneyama K., Aminuddin A., Mahmood A., Sasaoka T., Mori H., To be K.
- Organizer
  American Diabetes Association 72nd Scientific Sessions
- Place of Presentation
  Philadelphia, USA
- Year and Date
  2012-06-09
- Data Source
  KAKENHI-PROJECT-22590971
[Presentation] Astaxanthin, a Strong Antioxidant, Regulates Insulin Signaling by Various Mechanisms In Vivo2012
- Author(s)
  Ishiki M., Nishida Y., Fujisaka S., Usui I., Tobe K.
- Organizer
  American Diabetes Association 72nd Scientific Sessions
- Place of Presentation
  Philadelphia(USA)
- Data Source
  KAKENHI-PROJECT-22590971
[Presentation] 慢性炎症とインスリン抵抗性脂肪組織マクロファージとSIRT1(シンポジウム)2012
- Author(s)
  薄井勲,藤坂志帆,瀧川章子,金谷由紀子,戸邉一之
- Organizer
  第55回日本糖尿病学会年次学術集会
- Place of Presentation
  横浜
- Year and Date
  2012-05-17
- Data Source
  KAKENHI-PROJECT-22590971
[Presentation] Myeloid Cell-specific Deletion of SIRT1 Impairs Glucose Metabolism wiht Enhanced Inflammatory Response to Hypoxia2012
- Author(s)
  Takikawa A., Usui I., Senda S., Fujisaka S., Hattori S., Tsuneyama K., Aminuddin A., Mahmood A., Sasaoka T., Mori H., Tobe K.
- Organizer
  American Diabetes Association 72nd Scientific Sessions
- Place of Presentation
  Philadelphia(USA)
- Data Source
  KAKENHI-PROJECT-22590971
[Presentation] Impact of Adipose Tissue Hypoxia on Macriphage Polarization in Diet-induced Obese Mice.2012
- Author(s)
  Fujisaka S., Usui I., Ikutani M., Aminuddin A., Senda S., Takikawa A., Ishiki M., Koshimizu Y., Tsuneyama K., Nagai Y., Takatsu K., To be K.
- Organizer
  American Diabetes Association 72nd Scientific Sessions
- Place of Presentation
  Philadelphia, USA
- Year and Date
  2012-06-09
- Data Source
  KAKENHI-PROJECT-22590971
[Presentation] インスリン抵抗性のメカニズムと新しい治療戦略脂肪組織マクロファージとインスリン抵抗性。(シンポジウム)2011
- Author(s)
  薄井勲、藤坂志帆、瀧川章子、仙田聡子、小清水由紀子、戸邉一之
- Organizer
  第54回日本糖尿病学会年次学術集会
- Place of Presentation
  札幌
- Year and Date
  2011-05-21
- Data Source
  KAKENHI-PROJECT-22590971
[Presentation] Obesity-induced hypoxia regulates the polarization of adipose tissuee macrophages2011
- Author(s)
  Fujisaka S., Usui I., Ikutani M., Kanatani Y, Senda S., Takikawa A., Aminuddin A., Suzuki H., Ishiki M., Iwata M., Nagai Y., Takatsu K., Tobe K.
- Organizer
  American Diabetes Association 71^<th> Scientific Sessions
- Place of Presentation
  San Diego
- Year and Date
  2011-06-26
- Data Source
  KAKENHI-PROJECT-22590971
[Presentation] Obesity-induced hypoxia regulates the polarization of adipose tissue macrophages.2011
- Author(s)
  FujisakaS., UsuiI., Ikutani M., Kanatani Y., Senda S., TakikawaA., Aminuddin, SuzukiH., IshikiM., IwataM., NagaiY., TakatsuK., To be K
- Organizer
  American Diabetes Association's 71st Scientific Sessions
- Place of Presentation
  San Diego, USA
- Year and Date
  2011-06-26
- Data Source
  KAKENHI-PROJECT-22590971
[Presentation] Astaxanthin, a strong antioxidant, possesses various effects on insulin signaling in vitro2011
- Author(s)
  Ishiki M., Nishida Y., Ishibashi H., Koshimizu Y., Fujisaka S., Usui I., Tobe K.
- Organizer
  American Diabetes Association 71^<th> Scientific Sessions
- Place of Presentation
  San Diego
- Year and Date
  2011-06-26
- Data Source
  KAKENHI-PROJECT-22590971
[Presentation] Hyperleptinemia induces leptin resistancce and further worsening obesity2011
- Author(s)
  Senda S., Inoue A., Suzuki R., Kamei N., Watanabe T., Mahmood A., Takikawa A., Aminuddin A., Fujisaka S., Koshimizu Y., Ishiki M., Usui I., Kadowaki T., To be K.
- Organizer
  American Diabetes Association's 71st Scientific Sessions
- Place of Presentation
  San Diego, USA
- Year and Date
  2011-06-26
- Data Source
  KAKENHI-PROJECT-22590971
[Presentation] 低酸素環境に対するM1/M2マクロファージの反応性に関する検討2011
- Author(s)
  藤坂志帆,薄井勲,生谷尚士,仙田聡子,瀧川章子,AminuddinAminuddin,金谷由紀子,長井良憲,石木学,戸邉一之
- Organizer
  第54回日本糖尿病学会年次学術集会
- Place of Presentation
  札幌
- Year and Date
  2011-05-21
- Data Source
  KAKENHI-PROJECT-22590971
[Presentation] 肥満脂肪組織の低酸素がマクロファージの極性に与える影響。(シンポジウム)2011
- Author(s)
  薄井勲、戸邉一之
- Organizer
  第32回日本肥満学会
- Place of Presentation
  兵庫
- Year and Date
  2011-09-23
- Data Source
  KAKENHI-PROJECT-22590971
[Presentation] Hyperleptinemia induces leptin resistancce and further worsening obesity2011
- Author(s)
  Senda S., Inoue A., Suzuki R., Kamei N., Watanabe T., Mahmood A., Takikawa A., Aminuddin A., Fujisaka S., Koshimizu Y., Ishiki M., Usui I., Kadowaki T., Tobe K.
- Organizer
  American Diabetes Association 71^<th> Scientific Sessions
- Place of Presentation
  San Diego
- Year and Date
  2011-06-26
- Data Source
  KAKENHI-PROJECT-22590971
[Presentation] The Effect of SRT1720 on Infalammation and Oxidative Stress in White Adipose Tissue of High Fat-fed Mice2010
- Author(s)
  Yukiko Kanatani, Isao Usui, Shiho Fujisaka, Yuji Matsuya, Satoko Senda, Akiko Takikawa, Aminuddin, Masaharu Urakaze, Kazuyuki Tobe
- Organizer
  American Diabetes Association 70^<th> scientific sessions
- Place of Presentation
  Orlando
- Data Source
  KAKENHI-PROJECT-22590971
[Presentation] PDGFR-β deletion improves diabetic nephropathy in CaM Kinase IIα (Thr286Asp) Transgenic Mice.2010
- Author(s)
  Suzuki H., Usui I., Kato I., Kanatani Y., Yamazaki Y., Fujisaka S., Senda S., Urakaze M., Sasahara M., Takasawa S., Okamoto H., Kobayashi M., Tobe K.
- Organizer
  The 70th American Diabetes Association Scientific Sessions
- Place of Presentation
  Orlando
- Data Source
  KAKENHI-PROJECT-22590971
[Presentation] 2型糖尿病のインスリン抵抗性における炎症の役割(学会賞受賞講演)2010
- Author(s)
  薄井勲
- Organizer
  第53回日本糖尿病学会年次学術集会
- Place of Presentation
  岡山
- Data Source
  KAKENHI-PROJECT-22590971
[Presentation] Activation of interleukin-10 signaling in hypothalamus decreases body weight and improves insulin sensitivity without affecting food intake.2010
- Author(s)
  Isao Usui, Shiho Fujisaka, Yukiko Kanatani, Agussalim Bukhali, Satoko Senda, Aminuddin, Kazuyuki Tobe
- Organizer
  The 70th American Diabetes Association Scientific Sessions
- Place of Presentation
  Orlando
- Data Source
  KAKENHI-PROJECT-22590971
[Presentation] SIRT1の活性化が肥満マウスの白色脂肪組織の炎症と酸化ストレスに与える影響2010
- Author(s)
  金谷由紀子、薄井勲、藤坂志帆、山崎夕、瀧川章子、鈴木ひかり、仙田聡子、Aminuddin石木学、浦風雅春、戸邉一之
- Organizer
  第53回日本糖尿病学会年次学術集会
- Place of Presentation
  岡山
- Data Source
  KAKENHI-PROJECT-22590971
[Presentation] 脂肪組織M1/M2マクロファージとインヌリン抵抗性の関連について2010
- Author(s)
  藤坂志帆, 薄井勲, アグッサリムブクハリ, 生谷尚士, 金谷由紀子, 山崎夕, 鈴木ひかり, 仙田聡子, 石木学, アミヌディン, 瀧川章子, 浦風雅春, 小林正, 戸辺一之
- Organizer
  第53回日本糖尿病学会年次学術集会
- Place of Presentation
  岡山
- Data Source
  KAKENHI-PROJECT-22590971
[Presentation] Regulation of body weight and insulin sensitivity by hypothalamic activation of interleukin-10 signaling(シンポジウム)2010
- Author(s)
  Isao Usui, Shiho Fujisaka, Yukiko Kanatani, Agussalim Bukhari, Satoko Senda, Aminuddin, Kazuyuki Tobe
- Organizer
  第53回日本糖尿病学会年次学術集会
- Place of Presentation
  岡山
- Data Source
  KAKENHI-PROJECT-22590971
[Presentation] マクロファージ特異的HIF-1α欠損は高脂肪食負荷マウスの糖代謝を改善する
- Author(s)
  瀧川章子，Mahmood A，藤坂志帆，仙田聡子，Aminuddin，中川崇，薄井勲，戸邉一之
- Organizer
  第51回日本臨床分子医学会学術集会
- Place of Presentation
  東京
- Year and Date
  2014-04-11 – 2014-04-12
- Data Source
  KAKENHI-PROJECT-25461333
[Presentation] 脂肪組織の慢性炎症における低酸素とマクロファージの関連
- Author(s)
  瀧川章子，薄井勲，藤坂志帆，Mahmood A，仙田聡子，Aminuddin，岡部圭介，角朝信，小清水由紀子，戸辺一之
- Organizer
  第57回日本糖尿病学会年次学術集会
- Place of Presentation
  大阪
- Year and Date
  2014-05-22 – 2014-05-24
- Data Source
  KAKENHI-PROJECT-25461333
[Presentation] 肥満脂肪組織の慢性炎症と低酸素シグナル
- Author(s)
  薄井　勲、瀧川章子、戸辺一之
- Organizer
  第57回日本糖尿病学会年次学術集会
- Place of Presentation
  大阪
- Year and Date
  2014-05-22 – 2014-05-24
- Data Source
  KAKENHI-PROJECT-25461333
[Presentation] Myeloid Cell-Specific Deletion of Hypoxia-Inducible Factor 1-alpha Gene Protected against Diet-Induced Insulin Resistance in Mice.
- Author(s)
  Takikawa A, Mahmood A, Fujisaka S, Nakagawa T, Senda S, Aminuddin A, Usui I, Tobe K.
- Organizer
  74th scientific sessions of American Diabetes Association
- Place of Presentation
  San Francisco
- Year and Date
  2014-06-13 – 2014-06-17
- Data Source
  KAKENHI-PROJECT-25461333
[Presentation] Myeloid-Specific deletion of Hypoxia-inducible factor 1-alpha gene protected against Diet induced Insulin resistance.
- Author(s)
  9.Mahmood A, Senda S, Nakagawa T, Fujisaka S, Takikawa A, Aminuddin A, Nawaz A, Usui I, Tobe K
- Organizer
  第57回日本糖尿病学会年次学術集会
- Place of Presentation
  大阪
- Year and Date
  2014-05-22 – 2014-05-24
- Data Source
  KAKENHI-PROJECT-25461333
[Presentation] Depletion of CD206-positive cells is associated with increased white adipose tissue proliferation.
- Author(s)
  Aminuddin, Takikawa A, Usui I, Fujisaka S, Mahmood A, Nawaz A, Tobe K
- Organizer
  第57回日本糖尿病学会年次学術集会
- Place of Presentation
  大阪
- Year and Date
  2014-05-22 – 2014-05-24
- Data Source
  KAKENHI-PROJECT-25461333
[Presentation] マクロファージ特異的HIF-1α欠損は高脂肪食負荷マウスの糖代謝を改善する
- Author(s)
  瀧川章子，Mahmood A，薄井勲，戸邉一之
- Organizer
  日本内分泌学会第32回内分泌代謝学サマーセミナー
- Place of Presentation
  山梨
- Year and Date
  2014-07-10 – 2014-07-12
- Data Source
  KAKENHI-PROJECT-25461333

1. TOBE Kazuyuki (30251242)

# of Collaborated Projects: 3 results

# of Collaborated Products: 34 results
2. Fujisaka Shiho (30512082)

# of Collaborated Projects: 3 results

# of Collaborated Products: 5 results
3. HAYAKAWA Yoshihiro (10541956)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. MINOKOSHI Yasuhiko (10200099)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. TSUNEYAMA Koichi (10293341)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
6. KOBAYASHI Masashi (80115758)

# of Collaborated Projects: 1 results

# of Collaborated Products: 10 results
7. 城島輝雄 (90420794)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 若尾宏 (10280950)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 八木邦公 (30293343)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
10. 卯木輝彦 (10963382)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 折笠秀樹 (20245038)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 中條大輔 (30640528)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 敷田幹文 (80272996)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 登丸琢也 (70594399)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. NAKAGAWA takashi

# of Collaborated Projects: 1 results

# of Collaborated Products: 11 results
16. NAGAI Yoshinori

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
17. NAKAMACHI Tomoya

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
18. GODA Nobuhito

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
19. 杉本博之

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
20. 安戸博美

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
21. 柳橋努

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
22. 山本誠士

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
23. 笹原正清

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
24. 小川佳宏

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
25. 佐田政隆

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
26. 山田和徳

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
27. 松井祥子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
28. 林龍二

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
29. NAWAZ ALLAH

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
30. 喜多紗斗美

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
31. 塩田清二

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
32. 大滝博和

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Usui Isao 薄井 勲

USUI Isao 薄井 勲

Research Projects

Research Products

Co-Researchers

白色脂肪組織特異的なPparg欠損が全身の糖・脂質代謝に及ぼす影響についての検討

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Elucidating the Heart Failure Formation Process as a Complication of Diabetes Mellitus by Electrocardiogram Machine Learning and Suppression by Advanced AI Clinical Practice

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糖尿病性心筋障害に対する糖尿病治療薬の影響に関する基礎的検討

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Regulation of glucose metabolism via microbial modification by dietary components

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a study about the role of MAIT cells in the browning of white adipose tissue and the regulation of glucose metabolismPrincipal Investigator

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Identification of gut microbiota- derived metabolites and the mechanisms that impair glucose metabolism

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the effects of CD206-positive macrophages on obesity-associated liver tumorsPrincipal Investigator

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Effect of obesity and diabetes on liver cancer and tumor-associated macrophage polarizationPrincipal Investigator

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Metabolic regulation by adipose tissue macrophage and interleulin-10Principal Investigator

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MECHANISMS FOR INSULIN RESISTANCE BY SERINE KINASE ACTIVATION

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[Book] 医学のあゆみ2016

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[Book] 月刊糖尿病2015

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[Book] 血管医学2014

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Usui Isao 薄井勲

USUI Isao 薄井勲

[Book] 最新臨床糖尿病学上-糖尿病学の最新動向-】糖尿病研究の進歩インスリン作用およびインスリン抵抗性発現機序インスリン抵抗性発現の分子機構インスリン抵抗性における炎症の役割.日本臨床2012