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NAGANUMA Akira  永沼 章

ORCIDConnect your ORCID iD *help
… Alternative Names

永沼 彰  ナガヌマ アキラ

永沼 章  ナガヌマ アキラ

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Researcher Number 80155952
Other IDs
Affiliation (based on the past Project Information) *help 2016 – 2019: 東北大学, 薬学研究科, 名誉教授
2015: 東北大学, 薬学研究科, 教授
2011 – 2015: 東北大学, 薬学研究科(研究院), 教授
2007 – 2012: Tohoku University, 大学院・薬学研究科, 教授
1999 – 2005: Graduate School of Pharmaceutical Sciences, Tohoku University, Professor, 大学院・薬学研究科, 教授 … More
2001: 東北大学, 大学院・医学系研究科, 教授
2001: 東北大学, 大学院・薬学系研究科, 教授
1994 – 1999: 東北大学, 薬学部, 教授
1993: 北里大学, 薬学部・公衆衛生学教室, 助教授
1990 – 1993: 北里大学, 薬学部, 助教授
1986 – 1987: 北里大学, 薬学部, 助教授
1986: 北里大, 薬学部, 助教授 Less
Review Section/Research Field
Principal Investigator
Environmental pharmacy / Biological pharmacy / 環境影響評価(含放射線生物学) / Biological Sciences / Environmental pharmacy / Risk sciences of radiation and chemicals / Hygiene / Risk sciences of radiation/Chemicals / Public health/Health science
Except Principal Investigator
Public health/Health science … More / Hygiene / Dermatology / Biological pharmacy / 環境影響評価(含放射線生物学) / Environmental pharmacy Less
Keywords
Principal Investigator
酵母 / メタロチオネイン / メチル水銀 / カドミウム / 耐性遺伝子 / シスプラチン / Cdc34 / スクリーニング / パラコート / 遺伝子多型 … More / siRNA / ユビキチン / 耐性 / グルタチオン / マウス / 合成誘導剤 / 毒性発現機構 / 転写因子 / Cin5 / Ydr259c / 遺伝子ノックダウン / メチル水銀毒性 / トキシコロジー / ユビキチン・プロテアソームシステム / MVBソーティングシステム / 毒性軽減機構 / 培養細胞 / 有害化学物質 / 蛋白質 / 環境 / 脳 / Yeast / Resistance / Methylmercury / Metallothionein / Cadmium / Polymorphism / Renal injury / GFAT / Rad23 / グルタチオンエステル / システイン / 細胞内代謝 / HPLC / gamma-グルタミルシステイン / gamma-グルタミルトランスペチダーゼ / gamma-GTP欠損症 / プロモーター / β-ガラクトシダーゼ / 転写促進 / 副作用軽減 / 制がん剤 / PF1070 / 遺伝子検索 / 毒性標的分子 / メチル水銀耐性 / 神経毒性 / 合成誘導 / 遺伝子プロモーター / 亜鉛 / ヒノキチオール / 高発現 / マイトマイシンC / 発現抑制 / Yap1 / 欠損細胞 / ノックダウン細胞 / 分子種特異的発現 / ヒト由来細胞 / ライブラリー / ヒト培養細胞 / 毒性発現調節 / 脱ユビキチン化酵素 / ピルビン酸 / 酸化ストレス / 過酸化水素 / 防御機構 / 液胞 / 細胞毒性 / 毒性増強機構 / プロテアソーム / 感受性決定因子 / ユビキチンプロテアソームシステム / 遺伝子 / 生体分子 / ケモカイン / CCL3 / CCL4 / 発現誘導 / カルシウム / ラット初代培養肝細胞 / 環境汚染物質 / 生体防御遺伝子 / 放射線 / 防御遺伝子 / Environmental Pollutants / Screening / Biodefense Factor / Irradiation / 痙攣 / PTZ-17 / ペンチレンテトラゾール / 遺伝子欠損細胞 / NM31 / 遺伝子発現 / Kidney / Promoter / グルコサミン6リン酸 / 細胞内標的分子 / グルコサミン / Ubiquitin / 高感受性集団 / 個体差 / 腎毒性 / MTF1 / High risk group / Individual difference / F-Box蛋白質 / methylmercury / toxicity / resistance / ubiquitin / F-box proteins / 毒性 / 転写調節 / シグナル伝達 / オートクライン / 脳神経疾患 … More
Except Principal Investigator
メタロチオネイン / 制癌剤 / アポトーシス / ノックアウトマウス / カドミウム / Metallothionein / 耐性 / 発癌抑制 / 副作用軽減 / 耐性克服 / シスプラチン / 耐性因子 / カドミウム耐性細胞 / セレン / 腎臓 / プロモーター異常 / Kidney / Cadmium / Polymorphism / Promoter / P-糖タンパク / 抗癌剤耐性 / 耐性タンパク / 耐性遺伝子 / 分子標的 / 癌転移 / モノクローナル抗体 / カルシウム拮抗剤 / ユビキチン / HeLa細胞 / プロパルジルグリシン / 皮膚 / 紫外線 / 増殖 / サンバーン細胞 / ディファレンシャルディスプレイ / 鉛 / 水銀 / 低濃度曝露 / 交絡因子 / 感受性 / アドリアマイシン / 制癌剤の毒性軽減 / ビスマス / 副作用軽減法 / フリーラジカル / 次硝酸ビスマス / マウス / 放射線 / セレン蛋白質 / 過酸化ストレス / ラジカルスカベンジャー / 遺伝子導入細胞 / 動物種差 / selenium / selenoproteins / oxidative stress / radical scavenger / transformants / species difference / 発癌 / 重金属 / Knockout mouse / Carcinogenesis / Heavy metal / Anticancer drug / Apoptosis / 遺伝子異常 / 腎障害 / Mtallothionein / Renal injury / 内分泌撹乱化学物質 / 環境ホルモン / 生殖異常 / 発生異常 / 野生動物 / 下水処理 / 内分泌攪乱化学物質 / Endocrine distuptors / Environmental hormones / Reproductive abnormalities / Developmental abnormalities / Wildlife / Sewage treatment / 亜鉛 / 腫瘍壊死因子 / 酸化的ストレス / ミトコンドリア / シトコンドリア / チトクロームC / METALLOTHIONEIN / APOPTOSIS / ZINC / TUMOR NECROSIS FACTOR / OXIDATIVE STRESS / MITOCHONDRIA / 一酸化窒素 / S-ニトロソ化 / 金属結合蛋白質 / 金属代謝 / グルタミン酸 / メチル水銀 / エンドトキシン / S-ニシロソ化 / メタラチオネイン / s-ニトロソ化 / Nitric Oxides / S-nitrosylation / Metal-binding proteins / Metal metabolism / Glutamate / Methylmercury / Endotoxin / 塩基配列異常 / エクソン3 / PCR-SSCP / 遺伝子多型 / Exon 3 Less
  • Research Projects

    (41 results)
  • Research Products

    (221 results)
  • Co-Researchers

    (54 People)
  •  Molecular mechanism for toxic effect of methylmercuryPrincipal Investigator

    • Principal Investigator
      NAGANUMA AKIRA
    • Project Period (FY)
      2015 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (S)
    • Research Field
      Risk sciences of radiation and chemicals
    • Research Institution
      Tohoku University
  •  Brain selective expression of chemokines by methylmercuryPrincipal Investigator

    • Principal Investigator
      Naganuma Akira
    • Project Period (FY)
      2014 – 2015
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Risk sciences of radiation and chemicals
    • Research Institution
      Tohoku University
  •  Explanation of the mechanism that influence the cell sensitivity to the toxicity of methylmercuryPrincipal Investigator

    • Principal Investigator
      NAGANUMA AKIRA
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Environmental pharmacy
    • Research Institution
      Tohoku University
  •  MVB sorting system as a novel defense mechanism against toxicity of cadmiumPrincipal Investigator

    • Principal Investigator
      NAGANUMA Akira
    • Project Period (FY)
      2011 – 2012
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Environmental pharmacy
    • Research Institution
      Tohoku University
  •  酸化ストレスに対する防御機構としてのMVBソーティングシステムPrincipal Investigator

    • Principal Investigator
      永沼 章
    • Project Period (FY)
      2008 – 2009
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Environmental pharmacy
    • Research Institution
      Tohoku University
  •  Cellular Systems Involved in Development and Regulation of Toxicity of MethylmercuryPrincipal Investigator

    • Principal Investigator
      NAGANUMA Akira
    • Project Period (FY)
      2007 – 2011
    • Research Category
      Grant-in-Aid for Scientific Research (S)
    • Research Field
      Risk sciences of radiation/Chemicals
    • Research Institution
      Tohoku University
  •  siRNAによる遺伝子ノックダウン法を利用したメチル水銀感受性決定遺伝子の検索Principal Investigator

    • Principal Investigator
      永沼 章
    • Project Period (FY)
      2005
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Environmental pharmacy
    • Research Institution
      Tohoku University
  •  siRNA法による全メタロチオネイン分子種発現抑制細胞の作成Principal Investigator

    • Principal Investigator
      永沼 章
    • Project Period (FY)
      2004
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Environmental pharmacy
    • Research Institution
      Tohoku University
  •  メタロチオネインのアミノ酸置換が引き起こす影響Principal Investigator

    • Principal Investigator
      永沼 章
    • Project Period (FY)
      2003
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Hygiene
    • Research Institution
      Tohoku University
  •  Studies on mechanism of toxicity of methylmercuryPrincipal Investigator

    • Principal Investigator
      NAGANUMA Akira
    • Project Period (FY)
      2003 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Environmental pharmacy
    • Research Institution
      Tohoku University
  •  メタロチオネインの遺伝子多型が引き起こす生育障害Principal Investigator

    • Principal Investigator
      永沼 章
    • Project Period (FY)
      2002
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Environmental pharmacy
    • Research Institution
      Tohoku University
  •  シスプラチンの細胞毒性発現に関与する蛋白質の同定とその機能解析Principal Investigator

    • Principal Investigator
      永沼 章
    • Project Period (FY)
      2001
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (C)
    • Review Section
      Biological Sciences
    • Research Institution
      Tohoku University
  •  重金属中毒学のパラダイムシフト

    • Principal Investigator
      SATOH Hiroshi
    • Project Period (FY)
      2001
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Hygiene
    • Research Institution
      Tohoku University
  •  Identification of a genetically high-risk group for cadmium toxicityPrincipal Investigator

    • Principal Investigator
      NAGANUMA Akira
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Environmental pharmacy
    • Research Institution
      Tohoku University
  •  シスプラチン耐性に関与するヒト細胞内因子の酵母を用いた検索Principal Investigator

    • Principal Investigator
      永沼 章
    • Project Period (FY)
      2000
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (C)
    • Review Section
      Biological Sciences
    • Research Institution
      Tohoku University
  •  Investigation of Target Molecules of Methylmercury ToxicityPrincipal Investigator

    • Principal Investigator
      NAGANUMA Akira
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Public health/Health science
    • Research Institution
      Tohoku University
  •  シスプラチン耐性に関与するヒト細胞内因子の酵母を用いた検索Principal Investigator

    • Principal Investigator
      永沼 章
    • Project Period (FY)
      1999
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Research Institution
      Tohoku University
  •  Effects of the s-nitrosylation of metal-binding proteins bu nitric oxides on the metabolism of metals

    • Principal Investigator
      NAKAI Kunihiko
    • Project Period (FY)
      1999 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Hygiene
    • Research Institution
      Tohoku University
  •  Mechanism of Individual Difference in Metallothionein Concentration in the Kidney

    • Principal Investigator
      MIYAIRI Shinichi
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (B).
    • Research Field
      Public health/Health science
    • Research Institution
      Tohoku University
  •  Role of metallothionein in mechanism of onset of epileptic seizurePrincipal Investigator

    • Principal Investigator
      NAGANUMA Akira
    • Project Period (FY)
      1998 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Biological pharmacy
    • Research Institution
      TOHOKU UNIVERSITY
  •  Polymorphism in the promoter and coding regions of human metallothionein IIA gene

    • Principal Investigator
      YOSHIDA Minoru
    • Project Period (FY)
      1998 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      環境影響評価(含放射線生物学)
    • Research Institution
      St. Marianna University
  •  Network of Endocrine Disruptor Research in Japan

    • Principal Investigator
      IGUCHI Taisen
    • Project Period (FY)
      1998
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Institution
      Yokohama City University
  •  MODIFICATION OF REACTIVE OXYGEN SPECIES-INDUCED CELL DEATH BY THE INCREASED ZINC IN RESPONSE TO STRESS

    • Principal Investigator
      SATO Masao
    • Project Period (FY)
      1998 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Environmental pharmacy
    • Research Institution
      TOKUSHIMA-BUNRIUNIVERSITY
  •  ヒノキチオールによるメタロチオネインの合成誘導と制癌剤の副作用軽減Principal Investigator

    • Principal Investigator
      永沼 章
    • Project Period (FY)
      1997
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Tohoku University
  •  紫外線障害に対する皮膚の防御機構:メタロチオネイン・ノックアウトマウスの光感受性

    • Principal Investigator
      花田 勝美
    • Project Period (FY)
      1997 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Dermatology
    • Research Institution
      Hirosaki University
  •  新しい重金属耐性因子の検索及び同定

    • Principal Investigator
      三浦 伸彦
    • Project Period (FY)
      1997
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Public health/Health science
    • Research Institution
      Tohoku University
  •  環境汚染物質の毒性に対する細胞内標的分子の検索Principal Investigator

    • Principal Investigator
      永沼 章
    • Project Period (FY)
      1996
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      環境影響評価(含放射線生物学)
    • Research Institution
      Tohoku University
  •  Physiological and Clinical Implication of Metallothionein

    • Principal Investigator
      IMURA Nobumasa
    • Project Period (FY)
      1996 – 1997
    • Research Category
      Grant-in-Aid for international Scientific Research
    • Research Field
      Biological pharmacy
    • Research Institution
      KITASATO UNIVERSITY
  •  生体内防御因子の合成促進による制がん剤の副作用軽減Principal Investigator

    • Principal Investigator
      永沼 章
    • Project Period (FY)
      1995
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Tohoku University
  •  Screening of Biodefense Factors for Toxicity of Environmental Pollutants or IrradiationPrincipal Investigator

    • Principal Investigator
      NAGANUMA Akira
    • Project Period (FY)
      1995 – 1997
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      環境影響評価(含放射線生物学)
    • Research Institution
      Tohoku University
  •  生体内防御因子の合成促進による制がん剤の副作用軽減Principal Investigator

    • Principal Investigator
      永沼 章
    • Project Period (FY)
      1994
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Tohoku University
  •  難治性癌の薬剤抵抗性の分子機構とその克服

    • Principal Investigator
      鶴尾 隆
    • Project Period (FY)
      1993
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      The University of Tokyo
  •  gamma-グルタミルシステインの尿中への排泄機構Principal Investigator

    • Principal Investigator
      永沼 章
    • Project Period (FY)
      1993
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Biological pharmacy
    • Research Institution
      Kitasato University
  •  Role of Selenium in Protection against Oxidative Stress

    • Principal Investigator
      IMURA Nobumasa
    • Project Period (FY)
      1993 – 1995
    • Research Category
      Grant-in-Aid for international Scientific Research
    • Research Institution
      Kitasato University
  •  メタロチオネインを利用した癌化学療法及び放射線療法における効果増強

    • Principal Investigator
      井村 伸正
    • Project Period (FY)
      1992
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Kitasato University
  •  メタロチオネインを利用した癌化学療法及び放射線療法における効果増強

    • Principal Investigator
      井村 伸正
    • Project Period (FY)
      1991
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Kitasato University
  •  メタロチオネインを利用した癌化学療法及び放射療法における効果増強

    • Principal Investigator
      IMURA Nobumasa
    • Project Period (FY)
      1990
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Kitasato University
  •  グルタチオンの細胞内代謝に関する研究Principal Investigator

    • Principal Investigator
      永沼 章
    • Project Period (FY)
      1990
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Biological pharmacy
    • Research Institution
      Kitasato University
  •  メタロチオネインなど制御可能な生体要因の量的質的調節による各種制癌剤の副作用軽減

    • Principal Investigator
      井村 伸正
    • Project Period (FY)
      1987
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      Kitasato University
  •  重金属代謝調節による重金属含有抗がん剤の効果増強法の開発

    • Principal Investigator
      井村 伸正
    • Project Period (FY)
      1986
    • Research Category
      Grant-in-Aid for Special Project Research
    • Research Institution
      Kitasato University
  •  カルシウムによる肝臓メタロチオネインの合成とその意義Principal Investigator

    • Principal Investigator
      永沼 章
    • Project Period (FY)
      1986
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Biological pharmacy
    • Research Institution
      Kitasato University

All 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2005 2003 Other

All Journal Article Presentation Book

  • [Book] 魚食と健康 ―メチル水銀の生物影響―2014

    • Author(s)
      黄 基旭、永沼 章(分担)
    • Total Pages
      151
    • Publisher
      恒星社厚生閣
    • Data Source
      KAKENHI-PROJECT-24249008
  • [Book] 毒性の科学2014

    • Author(s)
      永沼 章、黄 基旭(分担)
    • Total Pages
      200
    • Publisher
      東京大学出版会
    • Data Source
      KAKENHI-PROJECT-24249008
  • [Journal Article] The Nuclear Protein HOXB13 Enhances Methylmercury Toxicity by Inducing Oncostatin M and Promoting Its Binding to TNFR3 in Cultured Cells2019

    • Author(s)
      Toyama Takashi、Xu Sidi、Nakano Ryo、Hasegawa Takashi、Endo Naoki、Takahashi Tsutomu、Lee Jin-Yong、Naganuma Akira、Hwang Gi-Wook
    • Journal Title

      Cells

      Volume: 9 Pages: 45-45

    • DOI

      10.3390/cells9010045

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15H05714
  • [Journal Article] Evaluation of M1-microglial activation by neurotoxic metals using optimized organotypic cerebral slice cultures2019

    • Author(s)
      Hoshi T, Toyama T, Shinozaki Y, Koizumi S, Lee JY, Naganuma A, Hwang GW.
    • Journal Title

      J. Toxicol. Sci.

      Volume: 44 Issue: 7 Pages: 471-479

    • DOI

      10.2131/jts.44.471

    • NAID

      130007674444

    • ISSN
      0388-1350, 1880-3989
    • Language
      English
    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K06481, KAKENHI-PROJECT-19K16345, KAKENHI-PUBLICLY-18H05121, KAKENHI-PROJECT-15H05714, KAKENHI-PROJECT-16H04669, KAKENHI-PUBLICLY-19H04746
  • [Journal Article] Induction of chemokine CCL3 by NF-κB reduces methylmercury toxicity in C17.2 mouse neural stem cells2019

    • Author(s)
      Takahashi Tsutomu、Kim Min-Seok、Iwai-Shimada Miyuki、Hoshi Takayuki、Fujimura Masatake、Toyama Takashi、Fujiwara Yasuyuki、Naganuma Akira、Hwang Gi-Wook
    • Journal Title

      Environmental Toxicology and Pharmacology

      Volume: 71 Pages: 103216-103216

    • DOI

      10.1016/j.etap.2019.103216

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15H05714, KAKENHI-PROJECT-19H04276
  • [Journal Article] Methylmercury causes neuronal cell death via M1-microglial activation in organotypic slices prepared from mouse cerebral cortex2019

    • Author(s)
      Takayuki Hoshi, Takashi Toyama, Akira Naganuma, Gi-Wook Hwang
    • Journal Title

      Fundam. Toxicol. Sci.

      Volume: 6 Issue: 5 Pages: 167-170

    • DOI

      10.2131/fts.6.167

    • NAID

      130007674519

    • ISSN
      2189-115X
    • Language
      English
    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K16345, KAKENHI-PROJECT-15H05714
  • [Journal Article] Methylmercury induces the expression of chemokine CCL4 via SRF activation in C17.2 mouse neural stem cells.2019

    • Author(s)
      Min-Seok Kim, Tsutomu Takahashi, Jin-Yong Lee, Takashi Toyama, Takayuki Hoshi, Shusuke Kuge, Yasuyuki Fujiwara, Akira Naganuma, Gi-Wook Hwang
    • Journal Title

      Sci. Rep.

      Volume: 9 Pages: 1-11

    • DOI

      10.1038/s41598-019-41127-y

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15H05714, KAKENHI-PROJECT-16H02961, KAKENHI-PROJECT-18K06630
  • [Journal Article] Induced chemokine CCL4 has a protective role against methylmercury toxicity2018

    • Author(s)
      Tsutomu Takahashi, Min-Seok Kim, Miyuki Iwai-Shimada, Masatake Fujimura, Takashi Toyama, Akira Naganuma, Gi-Wook Hwang
    • Journal Title

      Toxics

      Volume: 36 Pages: 36-36

    • DOI

      10.3390/toxics6030036

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15H05714, KAKENHI-PROJECT-16H02961
  • [Journal Article] Methylmercury induces cytotoxicity through inhibition of PTEN activity by a decrease in its solubility2018

    • Author(s)
      Takumi Kobayashi, Takashi Toyama, Jin-Yong Lee, Nobuhiko Miura, Shunsuke Kuge, Akira Naganuma, Gi-Wook Hwang
    • Journal Title

      BPB Reports

      Volume: 1 Pages: 1-15

    • NAID

      130007938428

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15H05714
  • [Journal Article] Putrescine selectively alleviates methylmercury toxicity in C17.2 mouse neural stem cells2018

    • Author(s)
      Sato M., Lee J.Y., Kim M.S., Takahashi T, Naganuma A. and Hwang G.W.
    • Journal Title

      Fundam. Toxicol. Sci.

      Volume: 印刷中

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15H05714
  • [Journal Article] Activation of ornithine decarboxylase protects against methylmercury toxicity by increasing putrescine2018

    • Author(s)
      Masayuki Sato, Takashi Toyama, Jin-Yong Lee, Nobuhiko Miura, Akira Naganuma, Gi-Wook Hwang
    • Journal Title

      Toxicol. Appl. Pharmacol.

      Volume: 356 Pages: 120-126

    • DOI

      10.1016/j.taap.2018.08.002

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15H05714, KAKENHI-PROJECT-16H02961
  • [Journal Article] Effect of metallothionein-III on mercury-induced chemokine gene expression2018

    • Author(s)
      Lee JY, Tokumoto M, Hwang GW, Kim MS, Takahashi T, Naganuma A, Yoshida M, Satoh M
    • Journal Title

      Toxics

      Volume: 12;6(3). Pages: 48-48

    • DOI

      10.3390/toxics6030048

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K10029, KAKENHI-PROJECT-15H05714
  • [Journal Article] Putrescine selectively alleviates methylmercury toxicity in C17.2 mouse neural stem cells2018

    • Author(s)
      Masayuki Sato, Jin-Yong Lee, Min-Seok Kim, Tsutomu Takahashi, Akira Naganuma, Gi-Wook Hwang
    • Journal Title

      Fundam. Toxicol. Sci.

      Volume: 5 Issue: 2 Pages: 71-73

    • DOI

      10.2131/fts.5.71

    • NAID

      130006708560

    • ISSN
      2189-115X
    • Language
      English
    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15H05714, KAKENHI-PROJECT-16H02961
  • [Journal Article] Akr1 attenuates methylmercury toxicity through the palmitoylation of Meh1 as a subunit of the yeast EGO complex2017

    • Author(s)
      Zhang Z.T., Ogiwara Y., Ito Y., Hikida A., Miura N., Kuge S., Naganuma A. and Hwang G.W.
    • Journal Title

      Biochim. Biophys. Acta.

      Volume: 1861 Pages: 1729-1736

    • DOI

      10.1016/j.bbagen.2017.03.009

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15H05714, KAKENHI-PROJECT-16H02961
  • [Journal Article] Small interfering RNA-mediated knockdown of the transcription factor TCF3 enhances sensitivity to methylmercury in mouse neural stem cells2017

    • Author(s)
      Takahashi , Wang Y, Toyama T, Kim M. S., Kuge S., Hwang G. W., Naganuma A
    • Journal Title

      Fundam. Toxicol. Sci.

      Volume: 4 Issue: 2 Pages: 41-43

    • DOI

      10.2131/fts.4.41

    • NAID

      130005439338

    • ISSN
      2189-115X
    • Language
      English
    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K15488, KAKENHI-PROJECT-15H05714
  • [Journal Article] Identification of transcription factors activated by methylmercury in mouse brain2017

    • Author(s)
      Kim, M.S., Takahashi, T., Lee, J.Y., Miura, N., Asanuma, M., Hwang, G.W. and Naganuma, A.
    • Journal Title

      Fundam. Toxicol. Sci.

      Volume: 4(1) Issue: 1 Pages: 37-39

    • DOI

      10.2131/fts.4.37

    • NAID

      130005244551

    • ISSN
      2189-115X
    • Language
      English
    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K09673, KAKENHI-PROJECT-15H05714
  • [Journal Article] Whi2 enhances methylmercury toxicity in yeast via inhibition of Akr1 palmitoyltransferase activity2016

    • Author(s)
      Hwang G.W., Fukumitsu T., Ogiwara Y., Takahashi T., Miura, N., Kuge S. and Naganuma A.
    • Journal Title

      Biochim. Biophys. Acta.

      Volume: 1860 Pages: 1326-1333

    • DOI

      10.1016/j.bbagen.2016.03.026

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-25281023, KAKENHI-PROJECT-15H05714
  • [Journal Article] Transport of pyruvate into mitochondria is involved in methylmercury toxicity2016

    • Author(s)
      Lee J.Y., Ishida Y., Takahashia T., Naganuma A. and Hwang G.W.
    • Journal Title

      Sci. Rep.

      Volume: 6 Pages: 21518-21528

    • DOI

      10.1038/srep21518

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-25281023, KAKENHI-PROJECT-15H05714
  • [Journal Article] Methylmercury induces the expression of TNF-α selectively in the brain of mice2016

    • Author(s)
      Iwai-Shimada M., Takahashi T., Kim M.S., Fujimura M. Ito H., Toyama T., Naganuma A. and Hwang G.W.
    • Journal Title

      Sci. Rep.

      Volume: 6 Pages: 38249-38249

    • DOI

      10.1038/srep38294

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-15H05714
  • [Journal Article] Overexpression of palmitoyl transferase HIP14 confers resistance to methylmercury in SH-SY5Y human neuroblastoma cells2016

    • Author(s)
      Ogiwara Y., Miura N., Kuge S., Naganuma A. and Hwang G.W.
    • Journal Title

      Fundam. Toxicol. Sci.

      Volume: 3 Issue: 2 Pages: 75-77

    • DOI

      10.2131/fts.3.75

    • NAID

      130005140184

    • ISSN
      2189-115X
    • Language
      English
    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-25281023, KAKENHI-PROJECT-15H05714
  • [Journal Article] Methylmercury induces release of a cytotoxic factor from HEK293 cells into medium2015

    • Author(s)
      Toyama T., Murakami S., Kuge S., Hwang G.W. and Naganuma A.
    • Journal Title

      Fundam. Toxicol. Sci.

      Volume: 2 Issue: 5 Pages: 223-226

    • DOI

      10.2131/fts.2.223

    • NAID

      130005113420

    • ISSN
      2189-115X
    • Language
      English
    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15H05714
  • [Journal Article] Metabolomic analysis of low molecular weight substances released into medium from HEK293 cells treated with methylmercury2015

    • Author(s)
      Toyama T., Hwang G.W. and Naganuma A.
    • Journal Title

      Fundam. Toxicol. Sci.

      Volume: 2 Issue: 5 Pages: 227-228

    • DOI

      10.2131/fts.2.227

    • NAID

      130005131079

    • ISSN
      2189-115X
    • Language
      English
    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15H05714
  • [Journal Article] Citrulline enhances methylmercury toxicity in HEK293 and C17.2 cells2015

    • Author(s)
      Toyama T., Hwang G.W. and Naganuma A.
    • Journal Title

      Fundam. Toxicol. Sci.

      Volume: 2 Issue: 6 Pages: 229-231

    • DOI

      10.2131/fts.2.229

    • NAID

      130005131080

    • ISSN
      2189-115X
    • Language
      English
    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15H05714
  • [Journal Article] Identification of substrates of F-box protein involved in methylmercury toxicity in yeast cells2015

    • Author(s)
      Lee J.Y., Ishida Y., Kuge S.,Naganuma A. and Hwang G.W.
    • Journal Title

      FEBS Letters

      Volume: 589 Pages: 2720-2725

    • DOI

      10.1016/j.febslet.2015.08.016

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15H05714
  • [Journal Article] The protein transportation pathway from Golgi to vacuoles via endosomes plays a role in enhancement of methylmercury toxicity2014

    • Author(s)
      Hwang G.W., Murai Y., Takahashi T., Naganuma A.
    • Journal Title

      Scientific Reports

      Volume: 4 Pages: 5888-5888

    • DOI

      10.1038/srep05888

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-24249008, KAKENHI-PROJECT-25281023
  • [Journal Article] CDC23 knockdown reinforces methylmercury sensitivity in HEK293 cells2014

    • Author(s)
      Du K., Takahashi T., Iwai-Shimada M., Miura N., Naganuma A., Hwang G.W.
    • Journal Title

      Fundam. Toxicol. Sci.

      Volume: 1 Pages: 161-164

    • NAID

      130005083345

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-24249008
  • [Journal Article] Global chemokine expression in methylmercury-treated mice: methylmercury induces brain-specific expression of CCL3 and CCL42013

    • Author(s)
      Kim MS, Takahashi T, Lee JY, Hwang GW, Naganuma A
    • Journal Title

      J. Toxicol. Sci.

      Volume: 38 Issue: 6 Pages: 925-929

    • DOI

      10.2131/jts.38.925

    • NAID

      130004447096

    • ISSN
      0388-1350, 1880-3989
    • Language
      English
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24249008
  • [Journal Article] Low dose of methylmercury (MeHg) exposure induces caspase mediated-apoptosis in cultured neural progenitor cells2013

    • Author(s)
      Watanabe J, Nakamachi T, Ohtaki H, Naganuma A, Shioda S, Nakajo S
    • Journal Title

      J. Toxicol. Sci.

      Volume: 38 Issue: 6 Pages: 931-935

    • DOI

      10.2131/jts.38.931

    • NAID

      130004447097

    • ISSN
      0388-1350, 1880-3989
    • Language
      English
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24249008
  • [Journal Article] Brain-specific induction of secretoglobin 3A1 expression in mice treated with methylmercury2013

    • Author(s)
      Takahashi T, Kim MS, Saito T, Lee JY, Hwang GW, Naganuma A
    • Journal Title

      J. Toxicol. Sci.

      Volume: 38 Issue: 6 Pages: 963-965

    • DOI

      10.2131/jts.38.963

    • NAID

      130004447101

    • ISSN
      0388-1350, 1880-3989
    • Language
      English
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24249008
  • [Journal Article] Changes in the levels of low molecular weight metabolites in the mouse cerebellum following treatment with methylmercury2013

    • Author(s)
      Hwang GW1, Lee JY, Kim MS, Sato M, Takahashi T, Naganuma A
    • Journal Title

      J. Toxicol. Sci.

      Volume: 38 Issue: 5 Pages: 703-706

    • DOI

      10.2131/jts.38.703

    • NAID

      10031191729

    • ISSN
      0388-1350, 1880-3989
    • Language
      English
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24249008, KAKENHI-PROJECT-25281023
  • [Journal Article] Knockdown of the gene for homeobox protein HOXB13 reduces toxicity of oxidative-stress inducers in HEK293 cells2013

    • Author(s)
      Nakano R, Takahashi T, Naganuma A, Hwang GW
    • Journal Title

      J. Toxicol. Sci.

      Volume: 38 Issue: 6 Pages: 821-822

    • DOI

      10.2131/jts.38.821

    • NAID

      130004447084

    • ISSN
      0388-1350, 1880-3989
    • Language
      English
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24249008
  • [Journal Article] Deletion of the ubiquitin-conjugating enzyme Ubc2 confers resistance to methylmercury in budding yeast by promoting Whi2 degradation2013

    • Author(s)
      Hwang GW, Mastuyama F, Takahashi T, Lee JY, Naganuma A
    • Journal Title

      J. Toxicol. Sci.

      Volume: 38 Issue: 2 Pages: 301-303

    • DOI

      10.2131/jts.38.301

    • NAID

      10031151434

    • ISSN
      0388-1350, 1880-3989
    • Language
      English
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24249008
  • [Journal Article] Methylmercury induces a brain-specific increase in chemokine CCL4 expression in mice2012

    • Author(s)
      J.Y. Lee, A. Naganuma
    • Journal Title

      J. Toxicol. Sci.

      Volume: 37 Pages: 1279-1282

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24249008
  • [Journal Article] Identification of deubiquitinating enzymes involved in methylmercury toxicity in Saccharomyces cerevisiae2012

    • Author(s)
      G.W. Hwang, A. Naganuma
    • Journal Title

      J. Toxicol. Sci.

      Volume: 37 Pages: 1287-1290

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24249008
  • [Journal Article] Ubiquitin-conjugating enzyme Cdc34 mediates methylmercury resistance in Saccharomyces cerevisiae by increasing Whi2 degradation2012

    • Author(s)
      G.W. Hwang, A. Naganuma
    • Journal Title

      J. Toxicol. Sci.

      Volume: 37 Pages: 1283-1286

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24249008
  • [Journal Article] Methylmercury induces CCL2 expression through activation of NF-kappaB in human 1321N1 astrocytes2012

    • Author(s)
      M.S. Kim, A. Naganuma
    • Journal Title

      J. Toxicol. Sci.

      Volume: 37 Pages: 1275-1278

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24249008
  • [Journal Article] siRNA-mediated silencing of the gene for heat shock transcription factor 1 causes hypersensitivity to methylmercury in HEK293 cells2011

    • Author(s)
      Hwang, G.W., Naganuma A.
    • Journal Title

      J. Toxicol. Sci.

      Volume: 36 Issue: 6 Pages: 851-853

    • DOI

      10.2131/jts.36.851

    • NAID

      10030037163

    • ISSN
      0388-1350, 1880-3989
    • Language
      English
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19101003
  • [Journal Article] Gene expression profiling using DNA microarray analysis of the cerebellum of mice treated with methylmercury2011

    • Author(s)
      Hwang, G.W., Naganuma A.
    • Journal Title

      J. Toxicol. Sci.

      Volume: 36 Issue: 3 Pages: 389-391

    • DOI

      10.2131/jts.36.389

    • NAID

      10029136086

    • ISSN
      0388-1350, 1880-3989
    • Language
      English
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19101003
  • [Journal Article] siRNA-mediated silencing of the gene for heat shock transcription factor 1 causes hypersensitivity to methylmercury in HEK293 cells2011

    • Author(s)
      Hwang, G. W., Ryoke, K., Lee, J. Y., Takahashi, T. and Naganuma, A.
    • Journal Title

      J. Toxicol. Sci.

      Volume: 36 Pages: 851-853

    • NAID

      10030037163

    • URL

      http://dx.doi.org/10.2131/jts.36.851

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19101003
  • [Journal Article] Inhibition of F-box protein FBXO6 gene expression by RNA interference enhances cadmium toxicity in HEK293 cells2011

    • Author(s)
      Hwang, G. W., Du, K., Takahashi, T. and Naganuma, A.
    • Journal Title

      J. Toxicol. Sci.

      Volume: 36 Pages: 847-849

    • NAID

      10030037147

    • URL

      http://dx.doi.org/10.2131/jts.36.847

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19101003
  • [Journal Article] siRNA-mediated AMPK1 subunit gene PRKAA1 silencing enhances methylmercury toxicity in HEK293 cells2010

    • Author(s)
      Hwang, G.W., Naganuma, A.
    • Journal Title

      J.Toxicol.Sci. 35(印刷中)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19101003
  • [Journal Article] siRNA-mediated AMPKalpha1 subunit gene PRKAA1 silencing enhances methylmercury toxicity in HEK293 cells2010

    • Author(s)
      Hwang, G. W., Tobita, M., Takahashi, T. Kuge, S., Kita, K. and Naganuma, A.
    • Journal Title

      J. Toxicol. Sci.

      Volume: 35 Pages: 601-604

    • URL

      http://dx.doi.org/10.2131/jts.35.601

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19101003
  • [Journal Article] siRNA-mediated AMPK1 subunit gene PRKAA1 silencing enhances methylmercury toxicity in HEK293 cells2010

    • Author(s)
      Hwang, G. W., Tobita, M., Takahashi, T., Kuge, S., Kita, K., Naganuma, A.
    • Journal Title

      J. Toxicol. Sci. 34(in press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19101003
  • [Journal Article] Characterization of antioxidant protection of cultured neural progenitor cells(NPC)against methylmercury(MeHg)toxicity2009

    • Author(s)
      Watanabe, J., Naganuma, A.
    • Journal Title

      J.Toxicol.Sci. 34

      Pages: 315-325

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19101003
  • [Journal Article] Overexpression of the novel F-box protein Ymr258c confers resistance to methylmercury in Saccharomyces cerevisiae2009

    • Author(s)
      Hwang, G. W., Wada, N., Kuge, S., Naganuma, A.
    • Journal Title

      J. Toxicol. Sci. 34

      Pages: 413-416

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19101003
  • [Journal Article] Rip1 enhances methylmercury toxicity through production of reactive oxygen species (ROS) in budding yeast2009

    • Author(s)
      Lee, J. Y., Hwang, G. W., Naganuma, A.
    • Journal Title

      J. Toxicol. Sci. 34

      Pages: 715-717

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19101003
  • [Journal Article] Overexpression of the novel F-box protein Ymr258c confers resistance to methylmercury in Saccharomyces cerevisiae2009

    • Author(s)
      Hwang, G. W. Wada, N., Kuge, S. and Naganuma, A.
    • Journal Title

      J. Toxicol. Sci.

      Volume: 34 Pages: 413-416

    • URL

      http://dx.doi.org/10.2131/jts.34.413

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19101003
  • [Journal Article] Rip1 enhances methylmercury toxicity through production of reactive oxygen species (ROS)in budding yeast2009

    • Author(s)
      Lee, J. Y., Hwang, G. W. and Naganuma, A.
    • Journal Title

      J. Toxicol. Sci.

      Volume: 34 Pages: 715-717

    • URL

      http://dx.doi.org/10.2131/jts.34.715

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19101003
  • [Journal Article] Over expression of Ycg1 or Ydr520c confers resistance to cadmium in Saccharomyces cerevisiae2009

    • Author(s)
      Hwang, G. W., Sasaki, K., Takahashi, T., Yamamoto, R. and Naganuma, A.
    • Journal Title

      J. Toxicol. Sci.

      Volume: 34 Pages: 441-443

    • NAID

      110007359653

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19101003
  • [Journal Article] Overexpression of Ycg1 or Ydr520c confers resistance to cadmium in Saccharomyces cerevisiae2009

    • Author(s)
      Hwang, G.W., Naganuma, A.
    • Journal Title

      J.Toxicol.Sci. 34

      Pages: 441-443

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19101003
  • [Journal Article] Characterization of antioxidant protection of cultured neural progenitor cells (NPC)against methylmercury (Mega)toxicity2009

    • Author(s)
      Watanabe, J., Nakamachi, T., Ogawa, T., Naganuma, A., Nakamura, M., Shioda, S. and Nakajo, S.
    • Journal Title

      J. Toxicol. Sci.

      Volume: 34 Pages: 315-325

    • URL

      http://dx.doi.org/10.2131/jts.34.315

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19101003
  • [Journal Article] Rip 1 enhances methylmercury toxicity through production of reactive oxygen species(ROS)in budding yeast2009

    • Author(s)
      Lee, J.Y., Naganuma, A.
    • Journal Title

      J.Toxicol.Sci. 34

      Pages: 715-717

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19101003
  • [Journal Article] siRNA-mediated inhibition of phosphatidylinositol glycan class B (PIGB)confers resistance to methyl mercury in HEK293 cells2007

    • Author(s)
      Hwang, G. W., Hayashi, T., Kita, K., Takahashi, T., Kuge, S. and Naganuma, A.
    • Journal Title

      J. Toxicol. Sci.

      Volume: 32 Pages: 581-583

    • NAID

      110006531749

    • URL

      http://dx.doi.org/10.2131/jts.32.581

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19101003
  • [Journal Article] Identification of intracellular factors influenced in sensitivity of cells to methylmercury2005

    • Author(s)
      Naganuma, A.
    • Journal Title

      Proceedings of NMID Forum 2005

      Pages: 75-78

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15209004
  • [Journal Article] Biological interaction of dietary metals2003

    • Author(s)
      Naganuma, A.
    • Journal Title

      J.Toxicol.Sci. 28

      Pages: 249-249

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15209004
  • [Journal Article] Biological interaction of dietary metals2003

    • Author(s)
      Naganuma, A.
    • Journal Title

      J. Toxicol. Sci. 28

      Pages: 249-249

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15209004
  • [Journal Article] Intracellular factors involved in methylmercury toxicity in yeast2003

    • Author(s)
      Naganuma, A.
    • Journal Title

      Proceedings of International Symposium on Bio-Trace Elements 2002

      Pages: 69-70

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15209004
  • [Presentation] Elucidation of the mechanism involved in the induction of chemokine CCL4 expression by methylmercury2020

    • Author(s)
      Kim M.S., Takahashi T., Toyama T., Naganuma A. and Hwang G.W.
    • Organizer
      59th Annual Meeting of the Society of Toxicology
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H05714
  • [Presentation] A mechanism underlying methylmercury-induced TNF-α expression in mouse brain2020

    • Author(s)
      Hoshi T., Toyama T., Naganuma A. and Hwang G.W.
    • Organizer
      59th Annual Meeting of the Society of Toxicology
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H05714
  • [Presentation] メチル水銀によるマウス脳神経障害へのTNF受容体3の関与2020

    • Author(s)
      角田 洋平、外山 喬士、永沼 章、黄 基旭
    • Organizer
      日本薬学会第140年会
    • Data Source
      KAKENHI-PROJECT-15H05714
  • [Presentation] メチル水銀によるASK1/p38経路を介したTNF-α発現誘導機構2020

    • Author(s)
      星 尚志、外山 喬士、永沼 章、黄 基旭
    • Organizer
      日本薬学会第140年会
    • Data Source
      KAKENHI-PROJECT-15H05714
  • [Presentation] A mechanism underlying the enhancement of methylmercury toxicity through activation of transcription factor HOXB132020

    • Author(s)
      Toyama T., Xu S., Nakano R., Hasegawa T., Naganuma A. and Hwang G.W.
    • Organizer
      59th Annual Meeting of the Society of Toxicology
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H05714
  • [Presentation] RelB介したメチル水銀によるTNF-α発現誘導におけるtmRT1の役割2019

    • Author(s)
      金子 千華、外山 喬士、永沼 章、黄 基旭
    • Organizer
      第46回日本毒性学会学術年会
    • Data Source
      KAKENHI-PROJECT-15H05714
  • [Presentation] Induction mechanism of TNF-α expression by methylmercury in microglial BV-2 cells2019

    • Author(s)
      Hoshi T., Toyama T., Naganuma A. and Hwang G.W.
    • Organizer
      The 39th Annual International Conference of Toxicology
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H05714
  • [Presentation] メチル水銀によるマウス脳内でのオンコスタチンM産生細胞の同定とその発現誘導機構の解析2019

    • Author(s)
      星 尚志、外山 喬士、永沼 章、黄 基旭
    • Organizer
      第58回日本薬学会東北支部大会
    • Data Source
      KAKENHI-PROJECT-15H05714
  • [Presentation] メチル水銀によるtmRT1/RelB経路を介したTNF-αの発現誘導2019

    • Author(s)
      金子 千華、外山 喬士、永沼 章、黄 基旭
    • Organizer
      メタルバイオサイエンス研究会2019
    • Data Source
      KAKENHI-PROJECT-15H05714
  • [Presentation] メチル水銀によるTNF受容体3を介した細胞死誘導機構の解明2019

    • Author(s)
      角田 洋平、外山 喬士、星 尚志、永沼 章、黄 基旭
    • Organizer
      第46回日本毒性学会学術年会
    • Data Source
      KAKENHI-PROJECT-15H05714
  • [Presentation] メチル水銀によるミクログリアにおけるオンコスタチンMの発現誘導機構2019

    • Author(s)
      星 尚志、外山 喬士、永沼 章、黄 基旭
    • Organizer
      フォーラム2019衛生薬学・環境トキシコロジー
    • Data Source
      KAKENHI-PROJECT-15H05714
  • [Presentation] Mechanisms involved in the induction of TNF-α expression by methylmercury in mouse brain2019

    • Author(s)
      Takashi Toyama, Takayuki Hoshi, Akira Naganuma and Gi-Wook Hwang
    • Organizer
      Society of Toxicology 2019
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H05714
  • [Presentation] Elucidation of the mechanisms involved in methylmercury toxicity enhancement showed by the novel transcription factor tmRT12019

    • Author(s)
      Toyama T., Osaki K., Hwang G.W. and Naganuma A.
    • Organizer
      The 39th Annual International Conference of Toxicology
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H05714
  • [Presentation] Improvement of organotypic slice culture of mouse cerebral cortex to evaluate M1-microglial activation2019

    • Author(s)
      Takayuki Hoshi, Takashi Toyama, Akira Naganuma, Gi-Wook Hwang
    • Organizer
      Society of Toxicology 2019
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H05714
  • [Presentation] メチル水銀によるTNF受容体3を介した細胞死に関わる下流シグナル2019

    • Author(s)
      角田 洋平、外山 喬士、永沼 章、黄 基旭
    • Organizer
      メタルバイオサイエンス研究会2019
    • Data Source
      KAKENHI-PROJECT-15H05714
  • [Presentation] メチル水銀投与マウス脳内でのTNF-α発現誘導に関わる細胞種の特定とその機構2019

    • Author(s)
      星 尚志、外山 喬士、永沼 章、黄 基旭
    • Organizer
      第46回日本毒性学会学術年会
    • Data Source
      KAKENHI-PROJECT-15H05714
  • [Presentation] 改良型マウス大脳皮質スライス培養を用いたミクログリアを介したメチル水銀毒性発現機構の検討2019

    • Author(s)
      星尚志、外山喬士、永沼章、黄基旭
    • Organizer
      日本薬学会第139年会
    • Data Source
      KAKENHI-PROJECT-15H05714
  • [Presentation] Methylmercury causes neuronal cell death by impairing mitochondrial function via TNF receptor X2019

    • Author(s)
      Toyama T., Tsunoda Y., Hoshi T., Naganuma A. and Hwang G.W.
    • Organizer
      SfRBM 26th Annual Conference
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H05714
  • [Presentation] メチル水銀によるオンコスタチンM発現誘導機構2019

    • Author(s)
      黄 唯屹、外山 喬士、永沼 章、黄 基旭
    • Organizer
      第46回日本毒性学会学術年会
    • Data Source
      KAKENHI-PROJECT-15H05714
  • [Presentation] メチル水銀が示す神経細胞死誘導におけるTNF受容体3の関与2019

    • Author(s)
      角田 洋平、外山 喬士、星 尚志、永沼 章、黄 基旭
    • Organizer
      日本薬学会第139年会
    • Data Source
      KAKENHI-PROJECT-15H05714
  • [Presentation] 転写因子RelBの活性化を介したメチル水銀によるTNF-α発現誘導機構2019

    • Author(s)
      金子千華、外山喬士、永沼章、黄基旭
    • Organizer
      日本薬学会第139年会
    • Data Source
      KAKENHI-PROJECT-15H05714
  • [Presentation] メチル水銀毒性増強作用を示すオンコスタチンMの増加に関わる分子機構2019

    • Author(s)
      市川 貴之、外山 喬士、長谷川 貴、永沼 章、黄 基旭
    • Organizer
      第46回日本毒性学会学術年会
    • Data Source
      KAKENHI-PROJECT-15H05714
  • [Presentation] メチル水銀によるOSM蛋白質レベルの増加メカニズム2019

    • Author(s)
      外山 喬士、長谷川貴、永沼 章、黄 基旭
    • Organizer
      日本薬学会第139年会
    • Data Source
      KAKENHI-PROJECT-15H05714
  • [Presentation] メチル水銀により神経幹細胞から放出される細胞増殖阻害因子の探索とその産生機構2019

    • Author(s)
      外山 喬士、永沼 章、黄 基旭
    • Organizer
      フォーラム2019衛生薬学・環境トキシコロジー
    • Data Source
      KAKENHI-PROJECT-15H05714
  • [Presentation] Involvement of TNF receptor 3 in the neuronal damage caused by methylmercury in mouse brain and its expected mechanisms2019

    • Author(s)
      Tsunoda Y., Toyama T., Naganuma A. and Hwang G.W.
    • Organizer
      2019 Japan/Korea Joint Symposium on Pharmaceutical Health Science and Environmental Toxicology
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H05714
  • [Presentation] マウス神経幹細胞におけるメチル水銀によるTNF受容体3を介した細胞死誘導機構2019

    • Author(s)
      角田 洋平、外山 喬士、永沼 章、黄 基旭
    • Organizer
      第58回日本薬学会東北支部大会
    • Data Source
      KAKENHI-PROJECT-15H05714
  • [Presentation] メチル水銀毒性増強因子tmRT1を介したオンコスタチンMの発現誘導2019

    • Author(s)
      外山 喬士、黄 唯迄、許 思迪、永沼 章、黄 基旭
    • Organizer
      メタルバイオサイエンス研究会2019
    • Data Source
      KAKENHI-PROJECT-15H05714
  • [Presentation] Establishment of organotypic brain slice culture that can evaluate M1-microglial activation2019

    • Author(s)
      Hoshi T., Toyama T., Naganuma A. and Hwang G.W.
    • Organizer
      2019 Japan/Korea Joint Symposium on Pharmaceutical Health Science and Environmental Toxicology
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H05714
  • [Presentation] メチル水銀によるTNF受容体3を介したミトコンドリア機能障害2019

    • Author(s)
      角田 洋平、外山 喬士、永沼 章、黄 基旭
    • Organizer
      フォーラム2019衛生薬学・環境トキシコロジー
    • Data Source
      KAKENHI-PROJECT-15H05714
  • [Presentation] Functional analysis of XRCC6, a tmRT1-binding protein in the tmRT1 activation by methylmercury2018

    • Author(s)
      Yi-An Chen, Katsuhiro Osaki, Takashi Toyama, Akira Naganuma, Gi-Wook Hwang
    • Organizer
      ASIATOX 2018
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H05714
  • [Presentation] メチル水銀による傷害性ミクログリアへの活性化を介した神経細胞損傷2018

    • Author(s)
      星 尚志、外山 喬士、永沼 章、黄 基旭
    • Organizer
      フォーラム2018衛生薬学・環境トキシコロジー
    • Data Source
      KAKENHI-PROJECT-15H05714
  • [Presentation] A molecular mechanism for the induction of TNF-α expression by methylmercury in HEK293 cells2018

    • Author(s)
      Chika Kaneko, Takashi Toyama, Akira Naganuma, Gi-Wook Hwang
    • Organizer
      ASIATOX 2018
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H05714
  • [Presentation] メチル水銀によるRelBを介したTNF-α発現誘導機構2018

    • Author(s)
      金子 千華、外山 喬士、永沼 章、黄 基旭
    • Organizer
      メタルバイオサイエンス研究会 2018
    • Data Source
      KAKENHI-PROJECT-15H05714
  • [Presentation] A novel mechanism involved in the induction of TNF-α expression by methylmercury2018

    • Author(s)
      Chika Kaneko, Takashi Toyama, Akira Naganuma, Gi-Wook Hwang
    • Organizer
      2018 Japan/Korea Joint Symposium on Pharmaceutical Health Science and Environmental Toxicology
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H05714
  • [Presentation] Identification of the cytotoxicity-inducing factors that are released from cells by methylmercury2018

    • Author(s)
      Toyama T., Naganuma A. and Hwang G.W.
    • Organizer
      57th Annual Meeting of the Society of Toxicology, San Antonio, USA
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H05714
  • [Presentation] メチル水銀が示すマウス脳内での神経細胞死誘導作用へのTNF受容体3の関与2018

    • Author(s)
      角田 洋平、外山 喬士、星 尚志、永沼 章、黄 基旭
    • Organizer
      第57会日本薬学会東北支部大会
    • Data Source
      KAKENHI-PROJECT-15H05714
  • [Presentation] メチル水銀によるオンコスタチンMとTNF受容体3との結合促進機構の解析2018

    • Author(s)
      長谷川 貴、許 思迪、 外山 喬士、永沼 章、黄 基旭
    • Organizer
      日本薬学会第138年会
    • Data Source
      KAKENHI-PROJECT-15H05714
  • [Presentation] メチル水銀によるミクログリアでのTNF-α発現誘導機構2018

    • Author(s)
      外山喬士、星尚志、永沼章、黄基旭
    • Organizer
      第4回 次世代を担う若手のための レキュラトリーサイエンスフォーラム
    • Data Source
      KAKENHI-PROJECT-15H05714
  • [Presentation] メチル水銀が示すマウス脳神経障害とTNF受容体3との関わり2018

    • Author(s)
      角田 洋平、外山 喬士、星 尚志、永沼 章、黄 基旭
    • Organizer
      メタルバイオサイエンス研究会 2018
    • Data Source
      KAKENHI-PROJECT-15H05714
  • [Presentation] Elucidation of mechanisms underlying induction of tumor necrosis factor-α by methylmercury in mouse brain2018

    • Author(s)
      Murakami S., Toyama T., Hoshi N., Naganuma A. and Hwang G.W
    • Organizer
      57th Annual Meeting of the Society of Toxicology, San Antonio, USA
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H05714
  • [Presentation] メチル水銀によるオンコスタチンM蛋白質の増加機構の解析2018

    • Author(s)
      市川 貴之、長谷川 貴、外山 喬士、永沼 章、黄 基旭
    • Organizer
      第57会日本薬学会東北支部大会
    • Data Source
      KAKENHI-PROJECT-15H05714
  • [Presentation] メチル水銀が示す神経毒性への傷害性ミクログリアの関与2018

    • Author(s)
      星 尚志、外山 喬士、篠崎 陽一、小泉 修一、永沼 章、黄 基旭
    • Organizer
      第45回日本毒性学会学術年会
    • Data Source
      KAKENHI-PROJECT-15H05714
  • [Presentation] メチル水銀毒性増強に関わるtmRT1と結合する核内蛋白質の同定2018

    • Author(s)
      陳 奕安、秋山 直行、大崎 勝弘、外山 喬士、永沼 章、黄 基旭
    • Organizer
      メタルバイオサイエンス研究会 2018
    • Data Source
      KAKENHI-PROJECT-15H05714
  • [Presentation] RIP1キナーゼを介したtmRT1のメチル水銀毒性増強作用2018

    • Author(s)
      外山 喬士、松田 健人、永沼 章、黄 基旭
    • Organizer
      メタルバイオサイエンス研究会 2018
    • Data Source
      KAKENHI-PROJECT-15H05714
  • [Presentation] メチル水銀投与マウス脳内でのオンコスタチンM発現誘導機構の解明2018

    • Author(s)
      黄 唯屹、外山 喬士、永沼 章、黄 基旭
    • Organizer
      メタルバイオサイエンス研究会 2018
    • Data Source
      KAKENHI-PROJECT-15H05714
  • [Presentation] メチル水銀によるTNF-α発現誘導に関わる新規メカニズム2018

    • Author(s)
      金子 千華、外山 喬士、永沼 章、黄 基旭
    • Organizer
      フォーラム2018衛生薬学・環境トキシコロジー
    • Data Source
      KAKENHI-PROJECT-15H05714
  • [Presentation] Methylmercury induced neuronal cell death via M1-microglia activation2018

    • Author(s)
      Takayuki Hoshi, Takashi Toyama, Akira Naganuma, Gi-Wook Hwang
    • Organizer
      2018 Japan/Korea Joint Symposium on Pharmaceutical Health Science and Environmental Toxicology
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H05714
  • [Presentation] A mechanism involved in the induction of oncostatin M expression by methylmercury2018

    • Author(s)
      Wei Yi Huang, Takashi Toyama, Takayuki Hoshi, Akira Naganuma, Gi-Wook Hwang
    • Organizer
      2018 Japan/Korea Joint Symposium on Pharmaceutical Health Science and Environmental Toxicology
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H05714
  • [Presentation] メチル水銀によるミクログリアでのTNF-α発現誘導機構2018

    • Author(s)
      星尚志、外山喬士、永沼章、黄基旭
    • Organizer
      第4回 次世代を担う若手のための レキュラトリーサイエンスフォーラム
    • Data Source
      KAKENHI-PROJECT-15H05714
  • [Presentation] メチル水銀によるオンコスタチンM蛋白質の増加機構の解析2018

    • Author(s)
      市川 貴之、長谷川 貴、外山 喬士、永沼 章、黄 基旭
    • Organizer
      メタルバイオサイエンス研究会 2018
    • Data Source
      KAKENHI-PROJECT-15H05714
  • [Presentation] Roles of the binding proteins of tmRT1, a novel transcription factor that involved in enhancement of methylmercury toxicity, in tmRT1 activation by methylmercury2018

    • Author(s)
      Chen Y.A., Osaki K., Togashi Y., Toyama T., Hwang G.W. and Naganuma A.
    • Organizer
      57th Annual Meeting of the Society of Toxicology, San Antonio, USA
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H05714
  • [Presentation] TNF受容体3を介したメチル水銀によるマウス脳神経傷害作用2018

    • Author(s)
      角田 洋平、外山 喬士、星 尚志、永沼 章、黄 基旭
    • Organizer
      フォーラム2018衛生薬学・環境トキシコロジー
    • Data Source
      KAKENHI-PROJECT-15H05714
  • [Presentation] メチル水銀によるシステイン残基の修飾を介したtmRT1の活性化機構2018

    • Author(s)
      二見 叔亮、外山 喬士、永沼 章、黄 基旭
    • Organizer
      日本薬学会第138年会
    • Data Source
      KAKENHI-PROJECT-15H05714
  • [Presentation] マウスの脳内でのメチル水銀によるTNF-α発現誘導機構の解析2018

    • Author(s)
      星 尚志、外山 喬士、永沼 章、黄 基旭
    • Organizer
      第57会日本薬学会東北支部大会
    • Data Source
      KAKENHI-PROJECT-15H05714
  • [Presentation] メチル水銀によるTNF-αの発現誘導に関わる転写因子の同定2018

    • Author(s)
      金子千華、外山喬士、野口 拓也、松沢 厚、永沼 章、黄基旭
    • Organizer
      第45回日本毒性学会学術年会
    • Data Source
      KAKENHI-PROJECT-15H05714
  • [Presentation] メチル水銀によるマウス脳神経障害へのTNF受容体3の関与2018

    • Author(s)
      外山喬士、戸田英汰、永沼章、黄基旭
    • Organizer
      第45回日本毒性学会学術年会
    • Data Source
      KAKENHI-PROJECT-15H05714
  • [Presentation] 大脳スライス培養系を用いたメチル水銀による神経傷害へのミクログリアの関与2018

    • Author(s)
      星 尚志、外山 喬士、永沼 章、黄 基旭
    • Organizer
      メタルバイオサイエンス研究会 2018
    • Data Source
      KAKENHI-PROJECT-15H05714
  • [Presentation] Identification of cells involved in the induction of tumor necrosis factor-α expression by methylmercury in the mouse brain and its molecular mechanisms2018

    • Author(s)
      Takayuki Hoshi, Takashi Toyama, Akira Naganuma, Gi-Wook Hwang
    • Organizer
      2018 ISES-ISEE
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H05714
  • [Presentation] tmRT1が示すメチル水銀毒性増強作用におけるRIP1の関与2018

    • Author(s)
      外山 喬士、松田 健人、永沼 章、黄 基旭
    • Organizer
      フォーラム2018衛生薬学・環境トキシコロジー
    • Data Source
      KAKENHI-PROJECT-15H05714
  • [Presentation] 新規転写因子tmRT1の活性化によるメチル水銀毒性増強作用におけるXRCC6の役割2017

    • Author(s)
      黄 基旭、陳 奕安、大崎 勝弘、外山 喬士、永沼 章
    • Organizer
      メタルバイオサイエンス研究会2017
    • Data Source
      KAKENHI-PROJECT-15H05714
  • [Presentation] メチル水銀毒性増強に関わる転写因子tmRT1と結合する蛋白質の同定2017

    • Author(s)
      冨樫 佑太、大崎 勝弘、陳 奕安、外山 喬士、永沼 章、黄 基旭
    • Organizer
      フォーラム2017衛生薬学・環境トキシコロジー
    • Data Source
      KAKENHI-PROJECT-15H05714
  • [Presentation] オンコスタチンMによるメチル水銀の細胞毒性増強に関わる分子機構2017

    • Author(s)
      永沼 章、許 思迪、外山 喬士、黄 基旭
    • Organizer
      メタルバイオサイエンス研究会2017
    • Data Source
      KAKENHI-PROJECT-15H05714
  • [Presentation] メチル水銀によるFOXA1を介したケモカインCCL4の発現誘導機2017

    • Author(s)
      渋井 雅志、金 ミンソク、永沼 章、黄 基旭
    • Organizer
      日本薬学会第137回年会
    • Place of Presentation
      仙台
    • Year and Date
      2017-03-27
    • Data Source
      KAKENHI-PROJECT-15H05714
  • [Presentation] Identification of a cytotoxic factor released from cells treated with methylmercury2017

    • Author(s)
      Toyama T., Naganuma A. and Hwang G.W.
    • Organizer
      The 12th International Conference and 5th Asian Congress on Environmental Mutagens, Incheon, Korea
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H05714
  • [Presentation] The role of XRCC6 in activation of tmRT1 induced by methylmercury in HEK293 cells2017

    • Author(s)
      Chen Y.A., Osaki K., Toyama T., Naganuma A. and Hwang G.W.
    • Organizer
      The 12th International Conference and 5th Asian Congress on Environmental Mutagens, Incheon, Korea
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H05714
  • [Presentation] メチル水銀投与マウスの脳内でのTNF-α発現誘導に関わる責任細胞の同定とその機構解析2017

    • Author(s)
      星 尚志、外山 喬士、村上聡一、永沼 章、黄 基旭
    • Organizer
      フォーラム2017衛生薬学・環境トキシコロジー
    • Data Source
      KAKENHI-PROJECT-15H05714
  • [Presentation] メチル水銀によるTNF-α発現誘導に関わるTNF-αプロモーター領域の解析2017

    • Author(s)
      金子 千華、外山 喬士、黄 基旭、永沼 章
    • Organizer
      第44回日本毒性学会学術年会
    • Data Source
      KAKENHI-PROJECT-15H05714
  • [Presentation] Analysis of tumor necrosis factor-α expression induced by methylmercury in mouse brain2017

    • Author(s)
      Hoshi T., Toyama T., Murakami S., Naganuma A. and Hwang G.W.
    • Organizer
      The 12th International Conference and 5th Asian Congress on Environmental Mutagens, Incheon, Korea
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H05714
  • [Presentation] メチル水銀によるアポトーシス誘導における転写因子TCF3の役割2017

    • Author(s)
      外山 喬士、王 妍コウ、永沼 章、黄 基旭
    • Organizer
      第56回日本薬学会東北支部大会
    • Data Source
      KAKENHI-PROJECT-15H05714
  • [Presentation] オンコスタチンMが示すメチル水銀毒性増強機構2017

    • Author(s)
      許 思迪、長谷川 貴、永沼 章、黄 基旭
    • Organizer
      日本薬学会第137回年会
    • Place of Presentation
      仙台
    • Year and Date
      2017-03-27
    • Data Source
      KAKENHI-PROJECT-15H05714
  • [Presentation] メチル水銀毒性の増強に関わる転写因子 tmRT1と結合する蛋白質の探索とその役割の解明2017

    • Author(s)
      陳 奕安、大崎 勝弘、外山 喬士、黄 基旭、永沼 章
    • Organizer
      第44回日本毒性学会学術年会
    • Data Source
      KAKENHI-PROJECT-15H05714
  • [Presentation] Identification of the binding proteins of tmRT1, a novel transcription factor, involved in enhancement of methylmercury toxicity2017

    • Author(s)
      Togashi Y., Osaki K., Chen Y. A., Toyama T., Naganuma A. and Hwang G.W.
    • Organizer
      The 12th International Conference and 5th Asian Congress on Environmental Mutagens, Incheon, Korea
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H05714
  • [Presentation] メチル水銀によるミクログリア細胞でのTNF-α発現誘導機構2017

    • Author(s)
      黄 基旭、村上 聡一、外山 喬士、永沼 章
    • Organizer
      第44回日本毒性学会学術年会
    • Data Source
      KAKENHI-PROJECT-15H05714
  • [Presentation] メチル水銀により活性化される転写因子の同定およびその役割2017

    • Author(s)
      王 妍コウ、外山 喬士、金 ミンソク、黄 基旭、永沼 章
    • Organizer
      日本薬学会第137回年会
    • Place of Presentation
      仙台
    • Year and Date
      2017-03-27
    • Data Source
      KAKENHI-PROJECT-15H05714
  • [Presentation] Role of oncostatin M in methylmercury toxicity2017

    • Author(s)
      Toda E., Xu S., Toyama T., Naganuma A., and Hwang G.W.
    • Organizer
      The 12th International Conference and 5th Asian Congress on Environmental Mutagens, Incheon, Korea
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H05714
  • [Presentation] メチル水銀によって活性化される新規転写因子tmRT1の結合蛋白質の解析2017

    • Author(s)
      外山 喬士、陳 奕安、冨樫 佑汰、大崎 勝弘、永沼 章、黄 基旭
    • Organizer
      メタルバイオサイエンス研究会2017
    • Data Source
      KAKENHI-PROJECT-15H05714
  • [Presentation] Functional Analysis of tmRT1, a Novel Transcription Factor, in the Induction of TNF-αGene Expression by Methylmercury2017

    • Author(s)
      N. Endo, A. Naganuma, G.W. Hwang
    • Organizer
      56th Annual Meeting of the Society of Toxicology
    • Place of Presentation
      Baltimore, USA
    • Year and Date
      2017-03-14
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H05714
  • [Presentation] メチル水銀投与マウス脳内でのTNF-α発現誘導機構2017

    • Author(s)
      星 尚志、外山 喬士、村上 聡一、永沼 章、黄 基旭
    • Organizer
      第56回日本薬学会東北支部大会
    • Data Source
      KAKENHI-PROJECT-15H05714
  • [Presentation] A mechanism for methylmercury induction of TNF-α in human TLR4-expressing HEK293 cells2017

    • Author(s)
      Kaneko C., Toyama T., Fukagawa S., Noguchi T., Matsuzawa A., Naganuma A. and Hwang G.W.
    • Organizer
      The 12th International Conference and 5th Asian Congress on Environmental Mutagens, Incheon, Korea
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H05714
  • [Presentation] メチル水銀投与マウス脳内で活性化される転写因子の同定とその活性化機構2017

    • Author(s)
      外山 喬士、王 妍コウ、金 ミンソク、永沼 章、黄 基旭
    • Organizer
      第44回日本毒性学会学術年会
    • Data Source
      KAKENHI-PROJECT-15H05714
  • [Presentation] Methylmercury Selectively Induces the Expression of TNF-α in the Mouse Brain2017

    • Author(s)
      Y. Iwai-Shimada, T. Takahashi, A. Naganuma, G.W. Hwang
    • Organizer
      56th Annual Meeting of the Society of Toxicology
    • Place of Presentation
      Baltimore, USA
    • Year and Date
      2017-03-14
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H05714
  • [Presentation] メチル水銀によるTNF-α発現誘導に関わる新規転写因子tmRT1の機能解析2017

    • Author(s)
      遠藤 直紀、小杉 健太、外山 喬士、永沼 章、黄 基旭
    • Organizer
      メタルバイオサイエンス研究会2017
    • Data Source
      KAKENHI-PROJECT-15H05714
  • [Presentation] tmRT1が示すメチル水銀毒性増強作用におけるアポトーシスの関与2017

    • Author(s)
      松田健人、外山 喬士、永沼 章、黄 基旭
    • Organizer
      メタルバイオサイエンス研究会2017
    • Data Source
      KAKENHI-PROJECT-15H05714
  • [Presentation] メチル水銀によるTNF-αの発現誘導機構2017

    • Author(s)
      金子 千華、外山 喬士、深川 隼、野口 拓也、松沢 厚、永沼 章、黄 基旭
    • Organizer
      フォーラム2017衛生薬学・環境トキシコロジー
    • Data Source
      KAKENHI-PROJECT-15H05714
  • [Presentation] メチル水銀投与マウス脳内でのTNF-α発現誘導およびその機構2017

    • Author(s)
      外山 喬士、村上 聡一、黄 基旭、永沼 章
    • Organizer
      日本薬学会第137回年会
    • Place of Presentation
      仙台
    • Year and Date
      2017-03-27
    • Data Source
      KAKENHI-PROJECT-15H05714
  • [Presentation] メチル水銀による脳特異的なセクレトロビン3A1誘導とその機構解析2016

    • Author(s)
      高橋 勉,趙 倩,齋藤隆寛,金ミンソク,黄 基旭,永沼 章
    • Organizer
      平成27年度メチル水銀研究ミーティング
    • Place of Presentation
      東京
    • Year and Date
      2016-01-07
    • Data Source
      KAKENHI-PROJECT-15H05714
  • [Presentation] メチル水銀によるTNF-α発現誘導に関与する新規転写因子tmRT1の機能解析2016

    • Author(s)
      遠藤 直紀 , 金子 千華 , 黄 基旭 , 永沼 章
    • Organizer
      第43回日本毒性学会学術年会
    • Place of Presentation
      名古屋
    • Year and Date
      2016-07-01
    • Data Source
      KAKENHI-PROJECT-15H05714
  • [Presentation] メチル水銀によるオートファジー誘導機構の解析2016

    • Author(s)
      長谷川 貴、松田 健人、永沼 章、黄 基旭
    • Organizer
      日本薬学会第136年会
    • Place of Presentation
      横浜
    • Year and Date
      2016-03-29
    • Data Source
      KAKENHI-PROJECT-15H05714
  • [Presentation] Role of MRTF, a novel transcription factor, in induction of TNF-α gene expression by methylmercury2016

    • Author(s)
      Naoki Endo, Akira Naganuma and Gi-Wook Hwang
    • Organizer
      55th Annual Meeting of the Society of Toxicology
    • Place of Presentation
      New Orelans, USA
    • Year and Date
      2016-03-14
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H05714
  • [Presentation] Identification of the cytotoxic factor which is released from HEK293 cells treated with methylmercury2016

    • Author(s)
      Takashi Toyama, Soichi Murakami, Gi-Wook Hwang, Akira Naganuma
    • Organizer
      Japan/Korea Joint Symposium on Pharmaceutical Health Sciences and Environmental Toxicology
    • Place of Presentation
      Tokyo
    • Year and Date
      2016-09-10
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H05714
  • [Presentation] オートファジー誘導へのメチル水銀の関与とその機構解析2016

    • Author(s)
      外山 喬士、長谷川 貴、松田 健人、黄 基旭、永沼 章
    • Organizer
      平成28年度メチル水銀研究ミーティング
    • Place of Presentation
      Tokyo
    • Year and Date
      2016-12-26
    • Invited
    • Data Source
      KAKENHI-PROJECT-15H05714
  • [Presentation] メチル水銀により細胞外へ放出されてメチル水銀毒性を増強する因子の探索2016

    • Author(s)
      外山 喬士 , 村上 聡一 , 小杉 健太 , 黄 基旭 , 永沼 章
    • Organizer
      第43回日本毒性学会学術年会
    • Place of Presentation
      名古屋
    • Year and Date
      2016-07-01
    • Data Source
      KAKENHI-PROJECT-15H05714
  • [Presentation] 新規転写因子tmRT1を介したメチル水銀によるTNFa発現誘導機構2016

    • Author(s)
      遠藤直紀、黄 基旭、永沼 章
    • Organizer
      メタルバイオサイエンス研究会サテライト2016
    • Place of Presentation
      静岡
    • Year and Date
      2016-08-18
    • Data Source
      KAKENHI-PROJECT-15H05714
  • [Presentation] Molecular mechanisms involved in enhancement of methylmercury toxicity by tmRT12016

    • Author(s)
      Sidi Xu, Akira Naganuma, Gi-Wook Hwang
    • Organizer
      Japan/Korea Joint Symposium on Pharmaceutical Health Sciences and Environmental Toxicology
    • Place of Presentation
      Tokyo
    • Year and Date
      2016-09-10
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H05714
  • [Presentation] メチル水銀による脳特異的なケモカイン誘導とその機構解析2015

    • Author(s)
      高橋 勉,金ミンソク,李 辰竜,黄 基旭,永沼 章
    • Organizer
      メタルバイオサイエンス研究会2015
    • Place of Presentation
      名古屋
    • Year and Date
      2015-08-26
    • Data Source
      KAKENHI-PROJECT-15H05714
  • [Presentation] Pyruvate incorporated into the mitochondria is involved in enhancement of methylmercury toxicity through mitochondrial membrane potential damage2015

    • Author(s)
      Jin-Yong Lee, Yosuke Ishida, Akira Naganuma, Gi-Wook Hwang
    • Organizer
      The 31th Annual Meeting of KSOT/KEMS
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2015-11-12
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H05714
  • [Presentation] メチル水銀によるアポトーシス誘導におけるプトレシンの役割2015

    • Author(s)
      佐藤昌幸、永沼 章、黄 基旭
    • Organizer
      第42回日本毒性学会学術年会
    • Place of Presentation
      金沢
    • Year and Date
      2015-06-30
    • Data Source
      KAKENHI-PROJECT-15H05714
  • [Presentation] Methylmercury in breast milk of Japanese mothers and lactational exposure of their infants2015

    • Author(s)
      Miyuki Iwai-Shimada, Hiroshi Satoh, Kunihiko Nakai, Nozomi Tatsuta, Katsuyuki Murata, Akira Naganuma, Hirokatsu Akagi
    • Organizer
      12th International Conference on Mercury as a Global Pollutant
    • Place of Presentation
      Jeju, Korea
    • Year and Date
      2015-06-18
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H05714
  • [Presentation] メチル水銀によるSCGB3A1発現誘導におけるNF-κBの関与2015

    • Author(s)
      高橋 勉,趙 倩,金ミンソク,岩井美幸,黄 基旭,永沼 章
    • Organizer
      フォーラム2015 衛生薬学・環境トキシコロジー
    • Place of Presentation
      神戸
    • Year and Date
      2015-09-01
    • Data Source
      KAKENHI-PROJECT-15H05714
  • [Presentation] 胎児期の残留性有機汚染物質曝露と出生体重および発達との関連性2015

    • Author(s)
      岩井美幸、龍田希、黒川修行、仲井邦彦、永沼章、佐藤洋
    • Organizer
      第42回日本毒性学会学術年会
    • Place of Presentation
      金沢
    • Year and Date
      2015-06-30
    • Data Source
      KAKENHI-PROJECT-15H05714
  • [Presentation] The role of EGO complex in methylmercury-induced abnormal vacuolar morphology in yeast cells2015

    • Author(s)
      Zhi-Ting Zhang, Akira Naganuma, Gi-Wook Hwang
    • Organizer
      The 7th International Congress of Asian Society of Toxicology
    • Place of Presentation
      Jeju, Korea
    • Year and Date
      2015-06-24
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H05714
  • [Presentation] Elucidating the role of HOXB13 in methylmercury toxicity by increase of TNF-α gene expression2015

    • Author(s)
      Naoki Endo, Akira Naganuma, Gi-Wook Hwang
    • Organizer
      The 7th International Congress of Asian Society of Toxicology
    • Place of Presentation
      Jeju, Korea
    • Year and Date
      2015-06-24
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H05714
  • [Presentation] Exposure to methylmercury via breast milk in Japanese infants2015

    • Author(s)
      Miyuki Iwai-Shimada, Hiroshi Satoh, Kunihiko Nakai, Nozomi Tatsuta, Katsuyuki Murata, Gi-Wook Hwang, Akira Naganuma, Hirokatsu Akagi
    • Organizer
      The 7th International Congress of Asian Society of Toxicology
    • Place of Presentation
      Jeju, Korea
    • Year and Date
      2015-06-24
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H05714
  • [Presentation] ポリアミン合成系によるメチル水銀毒性軽減機構の解析2014

    • Author(s)
      佐藤昌幸、黄基旭、永沼章
    • Organizer
      第53回日本薬学会東北支部大会
    • Place of Presentation
      いわき市
    • Year and Date
      2014-10-05
    • Data Source
      KAKENHI-PROJECT-24249008
  • [Presentation] Brain-specific induction of expression of Ccl4 and Scgb3a1 by methylmercury in mice2014

    • Author(s)
      Min-Seok Kim, Tsutomu Takahashi, Jin-Yong Lee, Gi-Wook Hwang, Akira Naganuma
    • Organizer
      53th Annual Meeting of the Society of Toxicology
    • Place of Presentation
      Phoenix (USA)
    • Data Source
      KAKENHI-PROJECT-24249008
  • [Presentation] The function of TEX27 on reduction of methylmercury toxicity2013

    • Author(s)
      Seong-Eun Oh, Gi-Wook Hwang, Akira Naganuma
    • Organizer
      The XIII International Congress of Toxicology
    • Place of Presentation
      Seoul(Korea)
    • Data Source
      KAKENHI-PROJECT-24249008
  • [Presentation] メチル水銀によってマウス脳特異的に発現誘導される遺伝子群2013

    • Author(s)
      金 ミンソク、斉藤隆寛、高橋 勉、李 辰竜、黄 基旭、永沼 章
    • Organizer
      第40回日本毒性学会学術年会
    • Place of Presentation
      千葉市
    • Data Source
      KAKENHI-PROJECT-24249008
  • [Presentation] ホメオボックス蛋白質HOX-B13が示すメチル水銀毒性増強におけるTNF-α の役割2013

    • Author(s)
      仲野 亮、福澤啓睦、黄 基旭、永沼 章
    • Organizer
      第40回日本毒性学会学術年会
    • Place of Presentation
      千葉市
    • Data Source
      KAKENHI-PROJECT-24249008
  • [Presentation] Screenings for Proteins that Influence Sensitivity of Cells to Methylmercury2013

    • Author(s)
      Akira Naganuma
    • Organizer
      The XIII International Congress of Toxicology
    • Place of Presentation
      Seoul(Korea)
    • Invited
    • Data Source
      KAKENHI-PROJECT-24249008
  • [Presentation] TNF-α/TNFR3シグナル伝達系を介したホメオボックス蛋白質HOXB13によるメチル水銀毒性増強機構2013

    • Author(s)
      仲野 亮、黄 基旭、永沼 章
    • Organizer
      フォーラム2013:衛生薬学・環境トキシコロジー
    • Place of Presentation
      福岡市
    • Data Source
      KAKENHI-PROJECT-24249008
  • [Presentation] Methylmercury Induces a Brain-Specific Increase in Chemokine CCL3 and CCL4 Expression in Mice2013

    • Author(s)
      Min-Seok Kim, Jin-Yong Lee, Tsutomu Takahashi, Gi-Wook Hwang, Akira Naganuma
    • Organizer
      The XIII International Congress of Toxicology
    • Place of Presentation
      Seoul(Korea)
    • Data Source
      KAKENHI-PROJECT-24249008
  • [Presentation] Molecular mechanism by which homeobox protein HOX-B13 augments methylmercury toxicity in HEK293 cells2013

    • Author(s)
      Ryo Nakano, Gi-Wook Hwang, Akira Naganuma
    • Organizer
      The XIII International Congress of Toxicology
    • Place of Presentation
      Seoul(Korea)
    • Data Source
      KAKENHI-PROJECT-24249008
  • [Presentation] 新規カドミウム毒性軽減因子としてのユビキチンリガーゼFBXO6の機能解析2012

    • Author(s)
      杜可、永沼章
    • Organizer
      日本薬学会第132年会
    • Place of Presentation
      札幌(招待講演)
    • Year and Date
      2012-03-31
    • Data Source
      KAKENHI-PROJECT-19101003
  • [Presentation] メチル水銀によるケモカイン発現誘導におけるNF-kBの関与2012

    • Author(s)
      金ミンソク、永沼章
    • Organizer
      日本薬学会第132年会
    • Place of Presentation
      札幌
    • Year and Date
      2012-03-31
    • Data Source
      KAKENHI-PROJECT-19101003
  • [Presentation] DNA microarray analysis of gene expression profiling in the cerebellum of mice treated with methylmercury2012

    • Author(s)
      Lee J.Y., Naganuma A.
    • Organizer
      51th Annual Meeting of the Society of Toxicology
    • Place of Presentation
      San Francisco (USA)
    • Year and Date
      2012-03-13
    • Data Source
      KAKENHI-PROJECT-19101003
  • [Presentation] ピルビン酸によるメチル水銀毒性増強作用とミトコンドリア機能障害との関係2011

    • Author(s)
      李辰竜、永沼章
    • Organizer
      平成23年度メチル水銀研究ミーティング
    • Place of Presentation
      東京
    • Year and Date
      2011-12-21
    • Data Source
      KAKENHI-PROJECT-19101003
  • [Presentation] メチル水銀毒性軽減蛋白質TEX27のメチル水銀による核移行2011

    • Author(s)
      呉成恩、永沼章
    • Organizer
      平成23年度メチル水銀研究ミーティング
    • Place of Presentation
      東京
    • Year and Date
      2011-12-21
    • Data Source
      KAKENHI-PROJECT-19101003
  • [Presentation] 新規メチル水銀毒性増強機構としての細胞内蛋白質輸送系の役割2011

    • Author(s)
      石川円華、黄基旭、永沼章
    • Organizer
      第50回日本薬学会東北支部大会
    • Place of Presentation
      仙台
    • Year and Date
      2011-11-30
    • Data Source
      KAKENHI-PROJECT-19101003
  • [Presentation] メチル水銀によるミトコンドリア機能障害に対するピルビン酸の増強作用2011

    • Author(s)
      李辰竜、黄基旭、永沼章
    • Organizer
      フォーラム2011:衛生薬学・環境トキシコロジー
    • Place of Presentation
      金沢
    • Year and Date
      2011-10-27
    • Data Source
      KAKENHI-PROJECT-19101003
  • [Presentation] Role of pyruvate in mitochondrial impairment by methylmercury toxicity2011

    • Author(s)
      Lee J.Y., Naganuma A.
    • Organizer
      The 27^<th> Annual Meeting of KSOT
    • Place of Presentation
      Jeju (Korea)
    • Year and Date
      2011-11-04
    • Data Source
      KAKENHI-PROJECT-19101003
  • [Presentation] 熱ショック転写因子HSF1が示すメチル水銀毒性軽減機構の解析2011

    • Author(s)
      領家克典、黄基旭、永沼章
    • Organizer
      第10回次世代を担う若手ファーマ・バイオフォーラム2011
    • Place of Presentation
      仙台
    • Year and Date
      2011-10-08
    • Data Source
      KAKENHI-PROJECT-19101003
  • [Presentation] Identification of new factors involved in reduction of methylmercury toxicity using whole-genome siRNA library2011

    • Author(s)
      Oh S.E., Naganuma A.
    • Organizer
      The 27^<th> Annual Meeting of KSOT
    • Place of Presentation
      Jeju (Korea)
    • Year and Date
      2011-11-04
    • Data Source
      KAKENHI-PROJECT-19101003
  • [Presentation] 熱ショック転写因子HSF1が示すメチル水銀毒性軽減機構の解析2011

    • Author(s)
      領家克典、永沼章
    • Organizer
      第10回次世代を担う若手ファーマ・バイオフォーラム
    • Place of Presentation
      仙台
    • Year and Date
      2011-10-08
    • Data Source
      KAKENHI-PROJECT-19101003
  • [Presentation] メチル水銀による熱ショック転写因子HSF1の活性化およびそれによるメチル水銀毒性軽減機構の解析2011

    • Author(s)
      領家克典、永沼章
    • Organizer
      フォーラム2011:衛生薬学・環境トキシコロジー
    • Place of Presentation
      金沢
    • Year and Date
      2011-10-27
    • Data Source
      KAKENHI-PROJECT-19101003
  • [Presentation] 機能未知蛋白質TEX27が示すメチル水銀毒性軽減作用の機構2011

    • Author(s)
      呉成恩、黄基旭、永沼章
    • Organizer
      第38回日本トキシコロジー学会
    • Place of Presentation
      横浜
    • Year and Date
      2011-07-11
    • Data Source
      KAKENHI-PROJECT-19101003
  • [Presentation] 薬毒物に対する生体内防御機構に関する研究2011

    • Author(s)
      永沼章
    • Organizer
      第38回日本トキシコロジー学会
    • Place of Presentation
      横浜(招待講演)
    • Year and Date
      2011-07-11
    • Data Source
      KAKENHI-PROJECT-19101003
  • [Presentation] 機能未知蛋白質TEX27の細胞内分布とメチル水銀毒性との関わり2011

    • Author(s)
      呉成恩、永沼章
    • Organizer
      フォーラム2011:衛生薬学・環境トキシコロジー
    • Place of Presentation
      金沢
    • Year and Date
      2011-10-27
    • Data Source
      KAKENHI-PROJECT-19101003
  • [Presentation] パルミチン酸転移酵Akr1が示すメチル水銀毒性軽減作用に関わる細胞内因子の同定およびその役割2011

    • Author(s)
      黄基旭、永沼章
    • Organizer
      第8回メタロチオネインおよびメタルバイオサイエンス研究会
    • Place of Presentation
      名古屋
    • Year and Date
      2011-12-09
    • Data Source
      KAKENHI-PROJECT-19101003
  • [Presentation] マウスにおけるメチル水銀によるケモカインリガンドの発現誘導2011

    • Author(s)
      李辰竜、永沼章
    • Organizer
      第8回メタロチオネインおよびメタルバイオサイエンス研究会
    • Place of Presentation
      名古屋
    • Year and Date
      2011-12-09
    • Data Source
      KAKENHI-PROJECT-19101003
  • [Presentation] メチル水銀によるミトコンドリア機能障害に与えるピルビン酸の影響2011

    • Author(s)
      李辰竜、永沼章
    • Organizer
      第38回日本トキシコロジー学会
    • Place of Presentation
      横浜
    • Year and Date
      2011-07-11
    • Data Source
      KAKENHI-PROJECT-19101003
  • [Presentation] 薬毒物に対する生体内防御機構に関する研究2011

    • Author(s)
      永沼章
    • Organizer
      第38回日本トキシコロジー学会
    • Place of Presentation
      横浜
    • Year and Date
      2011-07-11
    • Data Source
      KAKENHI-PROJECT-19101003
  • [Presentation] カドミウムによるアポトーシスにおけるユビキチンリガーゼFBXO6の関与2011

    • Author(s)
      杜可、永沼章
    • Organizer
      第38回日本トキシコロジー学会
    • Place of Presentation
      横浜
    • Year and Date
      2011-07-11
    • Data Source
      KAKENHI-PROJECT-19101003
  • [Presentation] Overexpression of Rad23 confers resistance to methylmercury in yeast cells via inhibition of degradation of Png2010

    • Author(s)
      Hwang, G. W., and Naganuma, A.
    • Organizer
      XII International Congress of Toxicology
    • Place of Presentation
      Barcelona(Spain)
    • Year and Date
      2010-07-22
    • Data Source
      KAKENHI-PROJECT-19101003
  • [Presentation] 新規メチル水銀毒性軽減因子TEX27の機能解析2010

    • Author(s)
      呉成恩、黄基旭、永沼章
    • Organizer
      フォーラム2010;衛生薬学・環境トキシコロジー
    • Place of Presentation
      東京
    • Year and Date
      2010-09-09
    • Data Source
      KAKENHI-PROJECT-19101003
  • [Presentation] メチル水銀毒性発現に関わる遺伝子群の合成二本鎖siRNAライブラリーを用いた検索2010

    • Author(s)
      呉成恩、永沼章
    • Organizer
      日本薬学会第130年会
    • Place of Presentation
      岡山
    • Year and Date
      2010-03-30
    • Data Source
      KAKENHI-PROJECT-19101003
  • [Presentation] ピルビン酸によるメチル水銀毒性増強作用における活性酸素種の関与2010

    • Author(s)
      李辰竜、永沼章
    • Organizer
      日本薬学会第130年会
    • Place of Presentation
      岡山
    • Year and Date
      2010-03-30
    • Data Source
      KAKENHI-PROJECT-19101003
  • [Presentation] パルミチン酸転移酵素Akr1によるメチル水銀毒性軽減におけるMeh1の関与2010

    • Author(s)
      伊藤悠一、黄基旭、疋田晃典、永沼章
    • Organizer
      フォーラム2010:衛生薬学・環境トキシコロジー
    • Place of Presentation
      東京
    • Year and Date
      2010-09-09
    • Data Source
      KAKENHI-PROJECT-19101003
  • [Presentation] メチル水銀感受性決定因子としての脱ユビキチン化酵素Ubp6の役割2010

    • Author(s)
      木村幸由, 黄基旭, 永沼章
    • Organizer
      日本薬学会第130年会
    • Place of Presentation
      岡山
    • Year and Date
      2010-03-30
    • Data Source
      KAKENHI-PROJECT-19101003
  • [Presentation] Overexpression of Cdc34 or Ubc4, ubiquitin-conjugating enzymes, confer resistance to cadmium through different mechanisms in yeast cells2010

    • Author(s)
      黄基旭, 永沼章
    • Organizer
      49th Annual Meeting of the Society of Toxicology
    • Place of Presentation
      Salt Lake City(USA)
    • Year and Date
      2010-03-09
    • Data Source
      KAKENHI-PROJECT-19101003
  • [Presentation] Involvement of Rip 1, a component of electron transport system complex III, in methylmercury toxicity in budding yeast2010

    • Author(s)
      李辰竜, 永沼章
    • Organizer
      49th Annual Meeting of the Society of Toxicology
    • Place of Presentation
      Salt Lake City(USA)
    • Year and Date
      2010-03-09
    • Data Source
      KAKENHI-PROJECT-19101003
  • [Presentation] リソソームへの細胞内輸送系を介してメチル水銀毒性増強に関与する因子の同定2009

    • Author(s)
      石川円華, 永沼章
    • Organizer
      フォーラム2009:衛生薬学・環境トキシコロジー
    • Place of Presentation
      沖縄
    • Year and Date
      2009-11-05
    • Data Source
      KAKENHI-PROJECT-19101003
  • [Presentation] メチル水銀毒性発現におけるユビキチン前駆体Ubi4の役割2009

    • Author(s)
      黄基旭、永沼章
    • Organizer
      第36回日本トキシコロジー学会学術年会
    • Place of Presentation
      盛岡
    • Year and Date
      2009-07-07
    • Data Source
      KAKENHI-PROJECT-19101003
  • [Presentation] メチル水銀感受性決定における脱ユビキチン化酵素Ubp6の役割2009

    • Author(s)
      木村幸由、永沼章
    • Organizer
      第48回日本薬学会東北支部大会
    • Place of Presentation
      仙台
    • Year and Date
      2009-10-18
    • Data Source
      KAKENHI-PROJECT-19101003
  • [Presentation] ユビキチン前駆体Ubi4によるメチル水銀毒性増強機構2009

    • Author(s)
      黄基旭、永沼章
    • Organizer
      メタロチオネインおよびメタルバイオサイエンス研究会
    • Place of Presentation
      東京
    • Year and Date
      2009-10-16
    • Data Source
      KAKENHI-PROJECT-19101003
  • [Presentation] 神経芽種細胞でのピルビン酸によるメチル水銀毒性増強作用2009

    • Author(s)
      李辰竜, 永沼章
    • Organizer
      フォーラム2009:衛生薬学・環境トキシコロジー
    • Place of Presentation
      沖縄
    • Year and Date
      2009-11-05
    • Data Source
      KAKENHI-PROJECT-19101003
  • [Presentation] メチル水銀毒性増強蛋白質Whi2のプロテアソームでの分解調節におけるUbp6およびRpn10の役割2009

    • Author(s)
      木村幸由、永沼章
    • Organizer
      メタロチオネインおよびメタルバイオサイエンス研究会
    • Place of Presentation
      東京
    • Year and Date
      2009-10-16
    • Data Source
      KAKENHI-PROJECT-19101003
  • [Presentation] メチル水銀毒性とユビキチン転移酵素群との関わり2009

    • Author(s)
      松山藤王、永沼章
    • Organizer
      第48回日本薬学会東北支部大会
    • Place of Presentation
      仙台
    • Year and Date
      2009-10-18
    • Data Source
      KAKENHI-PROJECT-19101003
  • [Presentation] Idenfication and functional analysis of novel genes involved in methylm ercury toxicity2009

    • Author(s)
      黄基旭, 永沼章
    • Organizer
      KSEH International Conference 2009
    • Place of Presentation
      Daegu(Korea)
    • Year and Date
      2009-06-05
    • Data Source
      KAKENHI-PROJECT-19101003
  • [Presentation] Overexpression of Cdc34 confers resistance to cadmium in yeast cells2009

    • Author(s)
      黄基旭, 永沼章
    • Organizer
      5^<th> International Congress of Asian Society of Toxicology
    • Place of Presentation
      Taipei(Taiwan)
    • Year and Date
      2009-07-12
    • Data Source
      KAKENHI-PROJECT-19101003
  • [Presentation] 複数のユビキチン転移酵素分子種間の相互作用によるメチル水銀感受性に制御2009

    • Author(s)
      松山藤王, 永沼章
    • Organizer
      フォーラム2009:衛生薬学・環境トキシコロジー
    • Place of Presentation
      沖縄
    • Year and Date
      2009-11-05
    • Data Source
      KAKENHI-PROJECT-19101003
  • [Presentation] ユビキチン・プロテアソームシステムが関わるメチル水銀感受性決定機構2008

    • Author(s)
      永沼 章
    • Organizer
      第78回日本衛生学会総会
    • Place of Presentation
      熊本
    • Year and Date
      2008-03-29
    • Data Source
      KAKENHI-PROJECT-19101003
  • [Presentation] メチル水銀感受性に決定におけるユビキチン転移酵素分子種問相互作用の関与2008

    • Author(s)
      松山藤王, 黄基旭, 永沼章
    • Organizer
      フォーラム2008 : 衛生薬学・環境トキシコロジー
    • Place of Presentation
      熊本
    • Year and Date
      2008-10-17
    • Data Source
      KAKENHI-PROJECT-19101003
  • [Presentation] 酵母におけるAkr1によるMeh1のパルミチン酸化を介したメチル水銀毒性軽減作用に関わる分子機構の解明

    • Author(s)
      永沼 章
    • Organizer
      第39回日本毒性学会学術年会
    • Place of Presentation
      仙台
    • Data Source
      KAKENHI-PROJECT-24249008
  • [Presentation] メチル水銀毒性発現における機能未知蛋白質TEX27の役割

    • Author(s)
      永沼 章
    • Organizer
      第2回重金属毒性機構解明に関する研究会
    • Place of Presentation
      十和田
    • Data Source
      KAKENHI-PROJECT-24249008
  • [Presentation] HOXB13が示すメチル水銀毒性増強作用の分子機構解析

    • Author(s)
      永沼 章
    • Organizer
      第39回日本毒性学会学術年会
    • Place of Presentation
      仙台
    • Data Source
      KAKENHI-PROJECT-24249008
  • [Presentation] Brain-specific expression of chemokines by methylmercury in mice

    • Author(s)
      永沼 章
    • Organizer
      The 6th International Congress of Asian Society of Toxicology
    • Place of Presentation
      仙台
    • Data Source
      KAKENHI-PROJECT-24249008
  • [Presentation] ホメオボックス蛋白質HOX-B13 が示すメチル水銀毒性増強作用の機構解析

    • Author(s)
      永沼 章
    • Organizer
      第12回分子予防環境医学研究会年会
    • Place of Presentation
      筑波
    • Data Source
      KAKENHI-PROJECT-24249008
  • [Presentation] The palmitoylation of Meh1, a component of EGO complex, has an important role in the reduction of methylmercury toxicity in budding yeast

    • Author(s)
      永沼 章
    • Organizer
      52th Annual Meeting of the Society of Toxicology
    • Place of Presentation
      San Antonio, USA
    • Data Source
      KAKENHI-PROJECT-24249008
  • [Presentation] The molecular mechanism underlying the reduction of methylmercury toxicity through the palmioylation of Meh1 by Akr1 in budding yeast

    • Author(s)
      永沼 章
    • Organizer
      The 6th International Congress of Asian Society of Toxicology
    • Place of Presentation
      仙台
    • Data Source
      KAKENHI-PROJECT-24249008
  • [Presentation] メチル水銀によってマウスの脳に特異的に発現誘導されるケモカイン

    • Author(s)
      永沼 章
    • Organizer
      第39回日本毒性学会学術年会
    • Place of Presentation
      仙台
    • Data Source
      KAKENHI-PROJECT-24249008
  • [Presentation] メチル水銀毒性発現における細胞内ポリアミン代謝系の関与

    • Author(s)
      佐藤 昌幸, 永沼 章, 黄 基旭
    • Organizer
      日本薬学会第135年会
    • Place of Presentation
      神戸市
    • Year and Date
      2015-03-26 – 2015-03-28
    • Data Source
      KAKENHI-PROJECT-24249008
  • [Presentation] Ego complex のメチル水銀毒性軽減作用におけるMeh1 パルミチン酸化の関与

    • Author(s)
      永沼 章
    • Organizer
      第51回日本薬学会東北支部大会
    • Place of Presentation
      青森
    • Data Source
      KAKENHI-PROJECT-24249008
  • [Presentation] マウス脳神経由来細胞におけるメチル水銀によるケモカインCCL4の発現誘導

    • Author(s)
      金ミンソク、李 辰竜、黄 基旭、高橋 勉、永沼 章
    • Organizer
      第52回日本薬学会東北支部大会
    • Place of Presentation
      仙台市
    • Data Source
      KAKENHI-PROJECT-24249008
  • [Presentation] メチル水銀によってマウス脳組織中で発現誘導されるサイトカイン

    • Author(s)
      岩井美幸、釋氏佑紀奈、金ミンソク、黄 基旭、高橋 勉、永沼 章
    • Organizer
      第41回日本毒性学会学術年会
    • Place of Presentation
      神戸市
    • Year and Date
      2014-07-02 – 2014-07-04
    • Data Source
      KAKENHI-PROJECT-26550037
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    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 24.  UMESONO Kazuhiko (50183752)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 25.  SATO Masao (20045743)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 26.  NAKAI Kunihiko (00291336)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 27.  KAMEO Satomi (40312558)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 28.  鶴尾 隆 (00012667)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 29.  八巻 寛 (30013329)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 30.  冨田 章弘 (40251483)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 31.  内藤 幹彦 (00198011)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 32.  中島 元夫 (90240738)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 33.  遊佐 敬介 (30200869)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 34.  花田 勝美 (80091627)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 35.  澤村 大輔 (60196334)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 36.  藤田 博美 (60142931)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 37.  遠山 千春 (10150872)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 38.  小野坂 敏見 (20068274)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 39.  横山 正夫 (80010304)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 40.  錦戸 典子 (10172644)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 41.  外山 喬士 (50720918)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 97 results
  • 42.  XIA Yiming
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 43.  BURK Raymond f
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 44.  LAZO John.S.
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 45.  IDE Tsuyoshi
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 46.  佐藤 雅彦
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 47.  YIMING Xia
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 48.  RAYMOND F Bu
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 49.  LAZO John S
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 50.  JOHN S. Laz
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 51.  SHINOZAKI Youichi
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 52.  LEE Jin-Yong
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 53.  小泉 修一
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 54.  浅沼 幹人
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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