NAGANUMA Akira 永沼章

… Alternative Names

永沼彰ナガヌマアキラ

永沼章ナガヌマアキラ

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Researcher Number	80155952
Other IDs
Affiliation (based on the past Project Information) *help	2016 – 2019: 東北大学, 薬学研究科, 名誉教授 2015: 東北大学, 薬学研究科, 教授 2011 – 2015: 東北大学, 薬学研究科(研究院), 教授 2007 – 2012: Tohoku University, 大学院・薬学研究科, 教授 1999 – 2005: Graduate School of Pharmaceutical Sciences, Tohoku University, Professor, 大学院・薬学研究科, 教授 … More 2001: 東北大学, 大学院・医学系研究科, 教授 2001: 東北大学, 大学院・薬学系研究科, 教授 1994 – 1999: 東北大学, 薬学部, 教授 1993: 北里大学, 薬学部・公衆衛生学教室, 助教授 1990 – 1993: 北里大学, 薬学部, 助教授 1986 – 1987: 北里大学, 薬学部, 助教授 1986: 北里大, 薬学部, 助教授 Less
Review Section/Research Field	Principal Investigator Environmental pharmacy / Biological pharmacy / 環境影響評価(含放射線生物学) / Biological Sciences / Environmental pharmacy / Risk sciences of radiation and chemicals / Hygiene / Risk sciences of radiation/Chemicals / Public health/Health science Except Principal Investigator Public health/Health science … More / Hygiene / Dermatology / Biological pharmacy / 環境影響評価(含放射線生物学) / Environmental pharmacy Less
Keywords	Principal Investigator 酵母 / メタロチオネイン / メチル水銀 / カドミウム / 耐性遺伝子 / シスプラチン / Cdc34 / スクリーニング / パラコート / 遺伝子多型 … More / siRNA / ユビキチン / 耐性 / グルタチオン / マウス / 合成誘導剤 / 毒性発現機構 / 転写因子 / Cin5 / Ydr259c / 遺伝子ノックダウン / メチル水銀毒性 / トキシコロジー / ユビキチン・プロテアソームシステム / MVBソーティングシステム / 毒性軽減機構 / 培養細胞 / 有害化学物質 / 蛋白質 / 環境 / 脳 / Yeast / Resistance / Methylmercury / Metallothionein / Cadmium / Polymorphism / Renal injury / GFAT / Rad23 / グルタチオンエステル / システイン / 細胞内代謝 / HPLC / gamma-グルタミルシステイン / gamma-グルタミルトランスペチダーゼ / gamma-GTP欠損症 / プロモーター / β-ガラクトシダーゼ / 転写促進 / 副作用軽減 / 制がん剤 / PF1070 / 遺伝子検索 / 毒性標的分子 / メチル水銀耐性 / 神経毒性 / 合成誘導 / 遺伝子プロモーター / 亜鉛 / ヒノキチオール / 高発現 / マイトマイシンC / 発現抑制 / Yap1 / 欠損細胞 / ノックダウン細胞 / 分子種特異的発現 / ヒト由来細胞 / ライブラリー / ヒト培養細胞 / 毒性発現調節 / 脱ユビキチン化酵素 / ピルビン酸 / 酸化ストレス / 過酸化水素 / 防御機構 / 液胞 / 細胞毒性 / 毒性増強機構 / プロテアソーム / 感受性決定因子 / ユビキチンプロテアソームシステム / 遺伝子 / 生体分子 / ケモカイン / CCL3 / CCL4 / 発現誘導 / カルシウム / ラット初代培養肝細胞 / 環境汚染物質 / 生体防御遺伝子 / 放射線 / 防御遺伝子 / Environmental Pollutants / Screening / Biodefense Factor / Irradiation / 痙攣 / PTZ-17 / ペンチレンテトラゾール / 遺伝子欠損細胞 / NM31 / 遺伝子発現 / Kidney / Promoter / グルコサミン6リン酸 / 細胞内標的分子 / グルコサミン / Ubiquitin / 高感受性集団 / 個体差 / 腎毒性 / MTF1 / High risk group / Individual difference / F-Box蛋白質 / methylmercury / toxicity / resistance / ubiquitin / F-box proteins / 毒性 / 転写調節 / シグナル伝達 / オートクライン / 脳神経疾患 … More Except Principal Investigator メタロチオネイン / 制癌剤 / アポトーシス / ノックアウトマウス / カドミウム / Metallothionein / 耐性 / 発癌抑制 / 副作用軽減 / 耐性克服 / シスプラチン / 耐性因子 / カドミウム耐性細胞 / セレン / 腎臓 / プロモーター異常 / Kidney / Cadmium / Polymorphism / Promoter / P-糖タンパク / 抗癌剤耐性 / 耐性タンパク / 耐性遺伝子 / 分子標的 / 癌転移 / モノクローナル抗体 / カルシウム拮抗剤 / ユビキチン / HeLa細胞 / プロパルジルグリシン / 皮膚 / 紫外線 / 増殖 / サンバーン細胞 / ディファレンシャルディスプレイ / 鉛 / 水銀 / 低濃度曝露 / 交絡因子 / 感受性 / アドリアマイシン / 制癌剤の毒性軽減 / ビスマス / 副作用軽減法 / フリーラジカル / 次硝酸ビスマス / マウス / 放射線 / セレン蛋白質 / 過酸化ストレス / ラジカルスカベンジャー / 遺伝子導入細胞 / 動物種差 / selenium / selenoproteins / oxidative stress / radical scavenger / transformants / species difference / 発癌 / 重金属 / Knockout mouse / Carcinogenesis / Heavy metal / Anticancer drug / Apoptosis / 遺伝子異常 / 腎障害 / Mtallothionein / Renal injury / 内分泌撹乱化学物質 / 環境ホルモン / 生殖異常 / 発生異常 / 野生動物 / 下水処理 / 内分泌攪乱化学物質 / Endocrine distuptors / Environmental hormones / Reproductive abnormalities / Developmental abnormalities / Wildlife / Sewage treatment / 亜鉛 / 腫瘍壊死因子 / 酸化的ストレス / ミトコンドリア / シトコンドリア / チトクロームC / METALLOTHIONEIN / APOPTOSIS / ZINC / TUMOR NECROSIS FACTOR / OXIDATIVE STRESS / MITOCHONDRIA / 一酸化窒素 / S-ニトロソ化 / 金属結合蛋白質 / 金属代謝 / グルタミン酸 / メチル水銀 / エンドトキシン / S-ニシロソ化 / メタラチオネイン / s-ニトロソ化 / Nitric Oxides / S-nitrosylation / Metal-binding proteins / Metal metabolism / Glutamate / Methylmercury / Endotoxin / 塩基配列異常 / エクソン3 / PCR-SSCP / 遺伝子多型 / Exon 3 Less

Molecular mechanism for toxic effect of methylmercuryPrincipal Investigator
- Principal Investigator
  
  NAGANUMA AKIRA
- Project Period (FY)
  2015 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Research Field
  
  Risk sciences of radiation and chemicals
- Research Institution
  Tohoku University
Brain selective expression of chemokines by methylmercuryPrincipal Investigator
- Principal Investigator
  
  Naganuma Akira
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Risk sciences of radiation and chemicals
- Research Institution
  Tohoku University
Explanation of the mechanism that influence the cell sensitivity to the toxicity of methylmercuryPrincipal Investigator
- Principal Investigator
  
  NAGANUMA AKIRA
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Environmental pharmacy
- Research Institution
  Tohoku University
MVB sorting system as a novel defense mechanism against toxicity of cadmiumPrincipal Investigator
- Principal Investigator
  
  NAGANUMA Akira
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Environmental pharmacy
- Research Institution
  Tohoku University
酸化ストレスに対する防御機構としてのMVBソーティングシステムPrincipal Investigator
- Principal Investigator
  
  永沼章
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Environmental pharmacy
- Research Institution
  Tohoku University
Cellular Systems Involved in Development and Regulation of Toxicity of MethylmercuryPrincipal Investigator
- Principal Investigator
  
  NAGANUMA Akira
- Project Period (FY)
  2007 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Research Field
  
  Risk sciences of radiation/Chemicals
- Research Institution
  Tohoku University
siRNAによる遺伝子ノックダウン法を利用したメチル水銀感受性決定遺伝子の検索Principal Investigator
- Principal Investigator
  
  永沼章
- Project Period (FY)
  2005
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Environmental pharmacy
- Research Institution
  Tohoku University
siRNA法による全メタロチオネイン分子種発現抑制細胞の作成Principal Investigator
- Principal Investigator
  
  永沼章
- Project Period (FY)
  2004
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Environmental pharmacy
- Research Institution
  Tohoku University
メタロチオネインのアミノ酸置換が引き起こす影響Principal Investigator
- Principal Investigator
  
  永沼章
- Project Period (FY)
  2003
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Hygiene
- Research Institution
  Tohoku University
Studies on mechanism of toxicity of methylmercuryPrincipal Investigator
- Principal Investigator
  
  NAGANUMA Akira
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Environmental pharmacy
- Research Institution
  Tohoku University
メタロチオネインの遺伝子多型が引き起こす生育障害Principal Investigator
- Principal Investigator
  
  永沼章
- Project Period (FY)
  2002
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Environmental pharmacy
- Research Institution
  Tohoku University
シスプラチンの細胞毒性発現に関与する蛋白質の同定とその機能解析Principal Investigator
- Principal Investigator
  
  永沼章
- Project Period (FY)
  2001
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Tohoku University
重金属中毒学のパラダイムシフト
- Principal Investigator
  
  SATOH Hiroshi
- Project Period (FY)
  2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hygiene
- Research Institution
  Tohoku University
Identification of a genetically high-risk group for cadmium toxicityPrincipal Investigator
- Principal Investigator
  
  NAGANUMA Akira
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Environmental pharmacy
- Research Institution
  Tohoku University
シスプラチン耐性に関与するヒト細胞内因子の酵母を用いた検索Principal Investigator
- Principal Investigator
  
  永沼章
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Tohoku University
Investigation of Target Molecules of Methylmercury ToxicityPrincipal Investigator
- Principal Investigator
  
  NAGANUMA Akira
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Public health/Health science
- Research Institution
  Tohoku University
シスプラチン耐性に関与するヒト細胞内因子の酵母を用いた検索Principal Investigator
- Principal Investigator
  
  永沼章
- Project Period (FY)
  1999
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Tohoku University
Effects of the s-nitrosylation of metal-binding proteins bu nitric oxides on the metabolism of metals
- Principal Investigator
  
  NAKAI Kunihiko
- Project Period (FY)
  1999 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Hygiene
- Research Institution
  Tohoku University
Mechanism of Individual Difference in Metallothionein Concentration in the Kidney
- Principal Investigator
  
  MIYAIRI Shinichi
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  Public health/Health science
- Research Institution
  Tohoku University
Role of metallothionein in mechanism of onset of epileptic seizurePrincipal Investigator
- Principal Investigator
  
  NAGANUMA Akira
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  TOHOKU UNIVERSITY
Polymorphism in the promoter and coding regions of human metallothionein IIA gene
- Principal Investigator
  
  YOSHIDA Minoru
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  環境影響評価(含放射線生物学)
- Research Institution
  St. Marianna University
Network of Endocrine Disruptor Research in Japan
- Principal Investigator
  
  IGUCHI Taisen
- Project Period (FY)
  1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Institution
  Yokohama City University
MODIFICATION OF REACTIVE OXYGEN SPECIES-INDUCED CELL DEATH BY THE INCREASED ZINC IN RESPONSE TO STRESS
- Principal Investigator
  
  SATO Masao
- Project Period (FY)
  1998 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Environmental pharmacy
- Research Institution
  TOKUSHIMA-BUNRIUNIVERSITY
ヒノキチオールによるメタロチオネインの合成誘導と制癌剤の副作用軽減Principal Investigator
- Principal Investigator
  
  永沼章
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tohoku University
紫外線障害に対する皮膚の防御機構：メタロチオネイン・ノックアウトマウスの光感受性
- Principal Investigator
  
  花田勝美
- Project Period (FY)
  1997 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Dermatology
- Research Institution
  Hirosaki University
新しい重金属耐性因子の検索及び同定
- Principal Investigator
  
  三浦伸彦
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Public health/Health science
- Research Institution
  Tohoku University
環境汚染物質の毒性に対する細胞内標的分子の検索Principal Investigator
- Principal Investigator
  
  永沼章
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  環境影響評価(含放射線生物学)
- Research Institution
  Tohoku University
Physiological and Clinical Implication of Metallothionein
- Principal Investigator
  
  IMURA Nobumasa
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Field
  
  Biological pharmacy
- Research Institution
  KITASATO UNIVERSITY
生体内防御因子の合成促進による制がん剤の副作用軽減Principal Investigator
- Principal Investigator
  
  永沼章
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tohoku University
Screening of Biodefense Factors for Toxicity of Environmental Pollutants or IrradiationPrincipal Investigator
- Principal Investigator
  
  NAGANUMA Akira
- Project Period (FY)
  1995 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  環境影響評価(含放射線生物学)
- Research Institution
  Tohoku University
生体内防御因子の合成促進による制がん剤の副作用軽減Principal Investigator
- Principal Investigator
  
  永沼章
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tohoku University
難治性癌の薬剤抵抗性の分子機構とその克服
- Principal Investigator
  
  鶴尾隆
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The University of Tokyo
gamma-グルタミルシステインの尿中への排泄機構Principal Investigator
- Principal Investigator
  
  永沼章
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Kitasato University
Role of Selenium in Protection against Oxidative Stress
- Principal Investigator
  
  IMURA Nobumasa
- Project Period (FY)
  1993 – 1995
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Institution
  Kitasato University
メタロチオネインを利用した癌化学療法及び放射線療法における効果増強
- Principal Investigator
  
  井村伸正
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kitasato University
メタロチオネインを利用した癌化学療法及び放射線療法における効果増強
- Principal Investigator
  
  井村伸正
- Project Period (FY)
  1991
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kitasato University
メタロチオネインを利用した癌化学療法及び放射療法における効果増強
- Principal Investigator
  
  IMURA Nobumasa
- Project Period (FY)
  1990
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kitasato University
グルタチオンの細胞内代謝に関する研究Principal Investigator
- Principal Investigator
  
  永沼章
- Project Period (FY)
  1990
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Kitasato University
メタロチオネインなど制御可能な生体要因の量的質的調節による各種制癌剤の副作用軽減
- Principal Investigator
  
  井村伸正
- Project Period (FY)
  1987
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Kitasato University
重金属代謝調節による重金属含有抗がん剤の効果増強法の開発
- Principal Investigator
  
  井村伸正
- Project Period (FY)
  1986
- Research Category
  
  Grant-in-Aid for Special Project Research
- Research Institution
  Kitasato University
カルシウムによる肝臓メタロチオネインの合成とその意義Principal Investigator
- Principal Investigator
  
  永沼章
- Project Period (FY)
  1986
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Kitasato University

[Book] 魚食と健康　―メチル水銀の生物影響―2014
- Author(s)
  黄　基旭、永沼　章（分担）
- Total Pages
  151
- Publisher
  恒星社厚生閣
- Data Source
  KAKENHI-PROJECT-24249008
[Book] 毒性の科学2014
- Author(s)
  永沼　章、黄　基旭（分担）
- Total Pages
  200
- Publisher
  東京大学出版会
- Data Source
  KAKENHI-PROJECT-24249008
[Journal Article] The Nuclear Protein HOXB13 Enhances Methylmercury Toxicity by Inducing Oncostatin M and Promoting Its Binding to TNFR3 in Cultured Cells2019
- Author(s)
  Toyama Takashi、Xu Sidi、Nakano Ryo、Hasegawa Takashi、Endo Naoki、Takahashi Tsutomu、Lee Jin-Yong、Naganuma Akira、Hwang Gi-Wook
- Journal Title
  
  Cells
  
  Volume: 9 Pages: 45-45
- DOI
  10.3390/cells9010045
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H05714
[Journal Article] Evaluation of M1-microglial activation by neurotoxic metals using optimized organotypic cerebral slice cultures2019
- Author(s)
  Hoshi T, Toyama T, Shinozaki Y, Koizumi S, Lee JY, Naganuma A, Hwang GW.
- Journal Title
  
  J. Toxicol. Sci.
  
  Volume: 44 Issue: 7 Pages: 471-479
- DOI
  10.2131/jts.44.471
- NAID
  130007674444
- ISSN
  0388-1350, 1880-3989
- Language
  English
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06481, KAKENHI-PROJECT-19K16345, KAKENHI-PUBLICLY-18H05121, KAKENHI-PROJECT-15H05714, KAKENHI-PROJECT-16H04669, KAKENHI-PUBLICLY-19H04746
[Journal Article] Induction of chemokine CCL3 by NF-κB reduces methylmercury toxicity in C17.2 mouse neural stem cells2019
- Author(s)
  Takahashi Tsutomu、Kim Min-Seok、Iwai-Shimada Miyuki、Hoshi Takayuki、Fujimura Masatake、Toyama Takashi、Fujiwara Yasuyuki、Naganuma Akira、Hwang Gi-Wook
- Journal Title
  
  Environmental Toxicology and Pharmacology
  
  Volume: 71 Pages: 103216-103216
- DOI
  10.1016/j.etap.2019.103216
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H05714, KAKENHI-PROJECT-19H04276
[Journal Article] Methylmercury causes neuronal cell death via M1-microglial activation in organotypic slices prepared from mouse cerebral cortex2019
- Author(s)
  Takayuki Hoshi, Takashi Toyama, Akira Naganuma, Gi-Wook Hwang
- Journal Title
  
  Fundam. Toxicol. Sci.
  
  Volume: 6 Issue: 5 Pages: 167-170
- DOI
  10.2131/fts.6.167
- NAID
  130007674519
- ISSN
  2189-115X
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K16345, KAKENHI-PROJECT-15H05714
[Journal Article] Methylmercury induces the expression of chemokine CCL4 via SRF activation in C17.2 mouse neural stem cells.2019
- Author(s)
  Min-Seok Kim, Tsutomu Takahashi, Jin-Yong Lee, Takashi Toyama, Takayuki Hoshi, Shusuke Kuge, Yasuyuki Fujiwara, Akira Naganuma, Gi-Wook Hwang
- Journal Title
  
  Sci. Rep.
  
  Volume: 9 Pages: 1-11
- DOI
  10.1038/s41598-019-41127-y
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H05714, KAKENHI-PROJECT-16H02961, KAKENHI-PROJECT-18K06630
[Journal Article] Induced chemokine CCL4 has a protective role against methylmercury toxicity2018
- Author(s)
  Tsutomu Takahashi, Min-Seok Kim, Miyuki Iwai-Shimada, Masatake Fujimura, Takashi Toyama, Akira Naganuma, Gi-Wook Hwang
- Journal Title
  
  Toxics
  
  Volume: 36 Pages: 36-36
- DOI
  10.3390/toxics6030036
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H05714, KAKENHI-PROJECT-16H02961
[Journal Article] Methylmercury induces cytotoxicity through inhibition of PTEN activity by a decrease in its solubility2018
- Author(s)
  Takumi Kobayashi, Takashi Toyama, Jin-Yong Lee, Nobuhiko Miura, Shunsuke Kuge, Akira Naganuma, Gi-Wook Hwang
- Journal Title
  
  BPB Reports
  
  Volume: 1 Pages: 1-15
- NAID
  130007938428
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H05714
[Journal Article] Putrescine selectively alleviates methylmercury toxicity in C17.2 mouse neural stem cells2018
- Author(s)
  Sato M., Lee J.Y., Kim M.S., Takahashi T, Naganuma A. and Hwang G.W.
- Journal Title
  
  Fundam. Toxicol. Sci.
  
  Volume: 印刷中
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H05714
[Journal Article] Activation of ornithine decarboxylase protects against methylmercury toxicity by increasing putrescine2018
- Author(s)
  Masayuki Sato, Takashi Toyama, Jin-Yong Lee, Nobuhiko Miura, Akira Naganuma, Gi-Wook Hwang
- Journal Title
  
  Toxicol. Appl. Pharmacol.
  
  Volume: 356 Pages: 120-126
- DOI
  10.1016/j.taap.2018.08.002
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H05714, KAKENHI-PROJECT-16H02961
[Journal Article] Effect of metallothionein-III on mercury-induced chemokine gene expression2018
- Author(s)
  Lee JY, Tokumoto M, Hwang GW, Kim MS, Takahashi T, Naganuma A, Yoshida M, Satoh M
- Journal Title
  
  Toxics
  
  Volume: 12;6(3). Pages: 48-48
- DOI
  10.3390/toxics6030048
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K10029, KAKENHI-PROJECT-15H05714
[Journal Article] Putrescine selectively alleviates methylmercury toxicity in C17.2 mouse neural stem cells2018
- Author(s)
  Masayuki Sato, Jin-Yong Lee, Min-Seok Kim, Tsutomu Takahashi, Akira Naganuma, Gi-Wook Hwang
- Journal Title
  
  Fundam. Toxicol. Sci.
  
  Volume: 5 Issue: 2 Pages: 71-73
- DOI
  10.2131/fts.5.71
- NAID
  130006708560
- ISSN
  2189-115X
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H05714, KAKENHI-PROJECT-16H02961
[Journal Article] Akr1 attenuates methylmercury toxicity through the palmitoylation of Meh1 as a subunit of the yeast EGO complex2017
- Author(s)
  Zhang Z.T., Ogiwara Y., Ito Y., Hikida A., Miura N., Kuge S., Naganuma A. and Hwang G.W.
- Journal Title
  
  Biochim. Biophys. Acta.
  
  Volume: 1861 Pages: 1729-1736
- DOI
  10.1016/j.bbagen.2017.03.009
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H05714, KAKENHI-PROJECT-16H02961
[Journal Article] Small interfering RNA-mediated knockdown of the transcription factor TCF3 enhances sensitivity to methylmercury in mouse neural stem cells2017
- Author(s)
  Takahashi , Wang Y, Toyama T, Kim M. S., Kuge S., Hwang G. W., Naganuma A
- Journal Title
  
  Fundam. Toxicol. Sci.
  
  Volume: 4 Issue: 2 Pages: 41-43
- DOI
  10.2131/fts.4.41
- NAID
  130005439338
- ISSN
  2189-115X
- Language
  English
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K15488, KAKENHI-PROJECT-15H05714
[Journal Article] Identification of transcription factors activated by methylmercury in mouse brain2017
- Author(s)
  Kim, M.S., Takahashi, T., Lee, J.Y., Miura, N., Asanuma, M., Hwang, G.W. and Naganuma, A.
- Journal Title
  
  Fundam. Toxicol. Sci.
  
  Volume: 4(1) Issue: 1 Pages: 37-39
- DOI
  10.2131/fts.4.37
- NAID
  130005244551
- ISSN
  2189-115X
- Language
  English
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09673, KAKENHI-PROJECT-15H05714
[Journal Article] Whi2 enhances methylmercury toxicity in yeast via inhibition of Akr1 palmitoyltransferase activity2016
- Author(s)
  Hwang G.W., Fukumitsu T., Ogiwara Y., Takahashi T., Miura, N., Kuge S. and Naganuma A.
- Journal Title
  
  Biochim. Biophys. Acta.
  
  Volume: 1860 Pages: 1326-1333
- DOI
  10.1016/j.bbagen.2016.03.026
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25281023, KAKENHI-PROJECT-15H05714
[Journal Article] Transport of pyruvate into mitochondria is involved in methylmercury toxicity2016
- Author(s)
  Lee J.Y., Ishida Y., Takahashia T., Naganuma A. and Hwang G.W.
- Journal Title
  
  Sci. Rep.
  
  Volume: 6 Pages: 21518-21528
- DOI
  10.1038/srep21518
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25281023, KAKENHI-PROJECT-15H05714
[Journal Article] Methylmercury induces the expression of TNF-α selectively in the brain of mice2016
- Author(s)
  Iwai-Shimada M., Takahashi T., Kim M.S., Fujimura M. Ito H., Toyama T., Naganuma A. and Hwang G.W.
- Journal Title
  
  Sci. Rep.
  
  Volume: 6 Pages: 38249-38249
- DOI
  10.1038/srep38294
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15H05714
[Journal Article] Overexpression of palmitoyl transferase HIP14 confers resistance to methylmercury in SH-SY5Y human neuroblastoma cells2016
- Author(s)
  Ogiwara Y., Miura N., Kuge S., Naganuma A. and Hwang G.W.
- Journal Title
  
  Fundam. Toxicol. Sci.
  
  Volume: 3 Issue: 2 Pages: 75-77
- DOI
  10.2131/fts.3.75
- NAID
  130005140184
- ISSN
  2189-115X
- Language
  English
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25281023, KAKENHI-PROJECT-15H05714
[Journal Article] Methylmercury induces release of a cytotoxic factor from HEK293 cells into medium2015
- Author(s)
  Toyama T., Murakami S., Kuge S., Hwang G.W. and Naganuma A.
- Journal Title
  
  Fundam. Toxicol. Sci.
  
  Volume: 2 Issue: 5 Pages: 223-226
- DOI
  10.2131/fts.2.223
- NAID
  130005113420
- ISSN
  2189-115X
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H05714
[Journal Article] Metabolomic analysis of low molecular weight substances released into medium from HEK293 cells treated with methylmercury2015
- Author(s)
  Toyama T., Hwang G.W. and Naganuma A.
- Journal Title
  
  Fundam. Toxicol. Sci.
  
  Volume: 2 Issue: 5 Pages: 227-228
- DOI
  10.2131/fts.2.227
- NAID
  130005131079
- ISSN
  2189-115X
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H05714
[Journal Article] Citrulline enhances methylmercury toxicity in HEK293 and C17.2 cells2015
- Author(s)
  Toyama T., Hwang G.W. and Naganuma A.
- Journal Title
  
  Fundam. Toxicol. Sci.
  
  Volume: 2 Issue: 6 Pages: 229-231
- DOI
  10.2131/fts.2.229
- NAID
  130005131080
- ISSN
  2189-115X
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H05714
[Journal Article] Identification of substrates of F-box protein involved in methylmercury toxicity in yeast cells2015
- Author(s)
  Lee J.Y., Ishida Y., Kuge S.,Naganuma A. and Hwang G.W.
- Journal Title
  
  FEBS Letters
  
  Volume: 589 Pages: 2720-2725
- DOI
  10.1016/j.febslet.2015.08.016
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H05714
[Journal Article] The protein transportation pathway from Golgi to vacuoles via endosomes plays a role in enhancement of methylmercury toxicity2014
- Author(s)
  Hwang G.W., Murai Y., Takahashi T., Naganuma A.
- Journal Title
  
  Scientific Reports
  
  Volume: 4 Pages: 5888-5888
- DOI
  10.1038/srep05888
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24249008, KAKENHI-PROJECT-25281023
[Journal Article] CDC23 knockdown reinforces methylmercury sensitivity in HEK293 cells2014
- Author(s)
  Du K., Takahashi T., Iwai-Shimada M., Miura N., Naganuma A., Hwang G.W.
- Journal Title
  
  Fundam. Toxicol. Sci.
  
  Volume: 1 Pages: 161-164
- NAID
  130005083345
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24249008
[Journal Article] Global chemokine expression in methylmercury-treated mice: methylmercury induces brain-specific expression of CCL3 and CCL42013
- Author(s)
  Kim MS, Takahashi T, Lee JY, Hwang GW, Naganuma A
- Journal Title
  
  J. Toxicol. Sci.
  
  Volume: 38 Issue: 6 Pages: 925-929
- DOI
  10.2131/jts.38.925
- NAID
  130004447096
- ISSN
  0388-1350, 1880-3989
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24249008
[Journal Article] Low dose of methylmercury (MeHg) exposure induces caspase mediated-apoptosis in cultured neural progenitor cells2013
- Author(s)
  Watanabe J, Nakamachi T, Ohtaki H, Naganuma A, Shioda S, Nakajo S
- Journal Title
  
  J. Toxicol. Sci.
  
  Volume: 38 Issue: 6 Pages: 931-935
- DOI
  10.2131/jts.38.931
- NAID
  130004447097
- ISSN
  0388-1350, 1880-3989
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24249008
[Journal Article] Brain-specific induction of secretoglobin 3A1 expression in mice treated with methylmercury2013
- Author(s)
  Takahashi T, Kim MS, Saito T, Lee JY, Hwang GW, Naganuma A
- Journal Title
  
  J. Toxicol. Sci.
  
  Volume: 38 Issue: 6 Pages: 963-965
- DOI
  10.2131/jts.38.963
- NAID
  130004447101
- ISSN
  0388-1350, 1880-3989
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24249008
[Journal Article] Changes in the levels of low molecular weight metabolites in the mouse cerebellum following treatment with methylmercury2013
- Author(s)
  Hwang GW1, Lee JY, Kim MS, Sato M, Takahashi T, Naganuma A
- Journal Title
  
  J. Toxicol. Sci.
  
  Volume: 38 Issue: 5 Pages: 703-706
- DOI
  10.2131/jts.38.703
- NAID
  10031191729
- ISSN
  0388-1350, 1880-3989
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24249008, KAKENHI-PROJECT-25281023
[Journal Article] Knockdown of the gene for homeobox protein HOXB13 reduces toxicity of oxidative-stress inducers in HEK293 cells2013
- Author(s)
  Nakano R, Takahashi T, Naganuma A, Hwang GW
- Journal Title
  
  J. Toxicol. Sci.
  
  Volume: 38 Issue: 6 Pages: 821-822
- DOI
  10.2131/jts.38.821
- NAID
  130004447084
- ISSN
  0388-1350, 1880-3989
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24249008
[Journal Article] Deletion of the ubiquitin-conjugating enzyme Ubc2 confers resistance to methylmercury in budding yeast by promoting Whi2 degradation2013
- Author(s)
  Hwang GW, Mastuyama F, Takahashi T, Lee JY, Naganuma A
- Journal Title
  
  J. Toxicol. Sci.
  
  Volume: 38 Issue: 2 Pages: 301-303
- DOI
  10.2131/jts.38.301
- NAID
  10031151434
- ISSN
  0388-1350, 1880-3989
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24249008
[Journal Article] Methylmercury induces a brain-specific increase in chemokine CCL4 expression in mice2012
- Author(s)
  J.Y. Lee, A. Naganuma
- Journal Title
  
  J. Toxicol. Sci.
  
  Volume: 37 Pages: 1279-1282
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24249008
[Journal Article] Identification of deubiquitinating enzymes involved in methylmercury toxicity in Saccharomyces cerevisiae2012
- Author(s)
  G.W. Hwang, A. Naganuma
- Journal Title
  
  J. Toxicol. Sci.
  
  Volume: 37 Pages: 1287-1290
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24249008
[Journal Article] Ubiquitin-conjugating enzyme Cdc34 mediates methylmercury resistance in Saccharomyces cerevisiae by increasing Whi2 degradation2012
- Author(s)
  G.W. Hwang, A. Naganuma
- Journal Title
  
  J. Toxicol. Sci.
  
  Volume: 37 Pages: 1283-1286
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24249008
[Journal Article] Methylmercury induces CCL2 expression through activation of NF-kappaB in human 1321N1 astrocytes2012
- Author(s)
  M.S. Kim, A. Naganuma
- Journal Title
  
  J. Toxicol. Sci.
  
  Volume: 37 Pages: 1275-1278
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24249008
[Journal Article] siRNA-mediated silencing of the gene for heat shock transcription factor 1 causes hypersensitivity to methylmercury in HEK293 cells2011
- Author(s)
  Hwang, G.W., Naganuma A.
- Journal Title
  
  J. Toxicol. Sci.
  
  Volume: 36 Issue: 6 Pages: 851-853
- DOI
  10.2131/jts.36.851
- NAID
  10030037163
- ISSN
  0388-1350, 1880-3989
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19101003
[Journal Article] Gene expression profiling using DNA microarray analysis of the cerebellum of mice treated with methylmercury2011
- Author(s)
  Hwang, G.W., Naganuma A.
- Journal Title
  
  J. Toxicol. Sci.
  
  Volume: 36 Issue: 3 Pages: 389-391
- DOI
  10.2131/jts.36.389
- NAID
  10029136086
- ISSN
  0388-1350, 1880-3989
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19101003
[Journal Article] siRNA-mediated silencing of the gene for heat shock transcription factor 1 causes hypersensitivity to methylmercury in HEK293 cells2011
- Author(s)
  Hwang, G. W., Ryoke, K., Lee, J. Y., Takahashi, T. and Naganuma, A.
- Journal Title
  
  J. Toxicol. Sci.
  
  Volume: 36 Pages: 851-853
- NAID
  10030037163
- URL
  http://dx.doi.org/10.2131/jts.36.851
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19101003
[Journal Article] Inhibition of F-box protein FBXO6 gene expression by RNA interference enhances cadmium toxicity in HEK293 cells2011
- Author(s)
  Hwang, G. W., Du, K., Takahashi, T. and Naganuma, A.
- Journal Title
  
  J. Toxicol. Sci.
  
  Volume: 36 Pages: 847-849
- NAID
  10030037147
- URL
  http://dx.doi.org/10.2131/jts.36.847
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19101003
[Journal Article] siRNA-mediated AMPK1 subunit gene PRKAA1 silencing enhances methylmercury toxicity in HEK293 cells2010
- Author(s)
  Hwang, G.W., Naganuma, A.
- Journal Title
  
  J.Toxicol.Sci. 35(印刷中)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19101003
[Journal Article] siRNA-mediated AMPKalpha1 subunit gene PRKAA1 silencing enhances methylmercury toxicity in HEK293 cells2010
- Author(s)
  Hwang, G. W., Tobita, M., Takahashi, T. Kuge, S., Kita, K. and Naganuma, A.
- Journal Title
  
  J. Toxicol. Sci.
  
  Volume: 35 Pages: 601-604
- URL
  http://dx.doi.org/10.2131/jts.35.601
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19101003
[Journal Article] siRNA-mediated AMPK1 subunit gene PRKAA1 silencing enhances methylmercury toxicity in HEK293 cells2010
- Author(s)
  Hwang, G. W., Tobita, M., Takahashi, T., Kuge, S., Kita, K., Naganuma, A.
- Journal Title
  
  J. Toxicol. Sci. 34(in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19101003
[Journal Article] Characterization of antioxidant protection of cultured neural progenitor cells(NPC)against methylmercury(MeHg)toxicity2009
- Author(s)
  Watanabe, J., Naganuma, A.
- Journal Title
  
  J.Toxicol.Sci. 34
  
  Pages: 315-325
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19101003
[Journal Article] Overexpression of the novel F-box protein Ymr258c confers resistance to methylmercury in Saccharomyces cerevisiae2009
- Author(s)
  Hwang, G. W., Wada, N., Kuge, S., Naganuma, A.
- Journal Title
  
  J. Toxicol. Sci. 34
  
  Pages: 413-416
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19101003
[Journal Article] Rip1 enhances methylmercury toxicity through production of reactive oxygen species (ROS) in budding yeast2009
- Author(s)
  Lee, J. Y., Hwang, G. W., Naganuma, A.
- Journal Title
  
  J. Toxicol. Sci. 34
  
  Pages: 715-717
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19101003
[Journal Article] Overexpression of the novel F-box protein Ymr258c confers resistance to methylmercury in Saccharomyces cerevisiae2009
- Author(s)
  Hwang, G. W. Wada, N., Kuge, S. and Naganuma, A.
- Journal Title
  
  J. Toxicol. Sci.
  
  Volume: 34 Pages: 413-416
- URL
  http://dx.doi.org/10.2131/jts.34.413
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19101003
[Journal Article] Rip1 enhances methylmercury toxicity through production of reactive oxygen species (ROS)in budding yeast2009
- Author(s)
  Lee, J. Y., Hwang, G. W. and Naganuma, A.
- Journal Title
  
  J. Toxicol. Sci.
  
  Volume: 34 Pages: 715-717
- URL
  http://dx.doi.org/10.2131/jts.34.715
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19101003
[Journal Article] Over expression of Ycg1 or Ydr520c confers resistance to cadmium in Saccharomyces cerevisiae2009
- Author(s)
  Hwang, G. W., Sasaki, K., Takahashi, T., Yamamoto, R. and Naganuma, A.
- Journal Title
  
  J. Toxicol. Sci.
  
  Volume: 34 Pages: 441-443
- NAID
  110007359653
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19101003
[Journal Article] Overexpression of Ycg1 or Ydr520c confers resistance to cadmium in Saccharomyces cerevisiae2009
- Author(s)
  Hwang, G.W., Naganuma, A.
- Journal Title
  
  J.Toxicol.Sci. 34
  
  Pages: 441-443
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19101003
[Journal Article] Characterization of antioxidant protection of cultured neural progenitor cells (NPC)against methylmercury (Mega)toxicity2009
- Author(s)
  Watanabe, J., Nakamachi, T., Ogawa, T., Naganuma, A., Nakamura, M., Shioda, S. and Nakajo, S.
- Journal Title
  
  J. Toxicol. Sci.
  
  Volume: 34 Pages: 315-325
- URL
  http://dx.doi.org/10.2131/jts.34.315
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19101003
[Journal Article] Rip 1 enhances methylmercury toxicity through production of reactive oxygen species(ROS)in budding yeast2009
- Author(s)
  Lee, J.Y., Naganuma, A.
- Journal Title
  
  J.Toxicol.Sci. 34
  
  Pages: 715-717
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19101003
[Journal Article] siRNA-mediated inhibition of phosphatidylinositol glycan class B (PIGB)confers resistance to methyl mercury in HEK293 cells2007
- Author(s)
  Hwang, G. W., Hayashi, T., Kita, K., Takahashi, T., Kuge, S. and Naganuma, A.
- Journal Title
  
  J. Toxicol. Sci.
  
  Volume: 32 Pages: 581-583
- NAID
  110006531749
- URL
  http://dx.doi.org/10.2131/jts.32.581
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19101003
[Journal Article] Identification of intracellular factors influenced in sensitivity of cells to methylmercury2005
- Author(s)
  Naganuma, A.
- Journal Title
  
  Proceedings of NMID Forum 2005
  
  Pages: 75-78
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15209004
[Journal Article] Biological interaction of dietary metals2003
- Author(s)
  Naganuma, A.
- Journal Title
  
  J.Toxicol.Sci. 28
  
  Pages: 249-249
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15209004
[Journal Article] Biological interaction of dietary metals2003
- Author(s)
  Naganuma, A.
- Journal Title
  
  J. Toxicol. Sci. 28
  
  Pages: 249-249
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15209004
[Journal Article] Intracellular factors involved in methylmercury toxicity in yeast2003
- Author(s)
  Naganuma, A.
- Journal Title
  
  Proceedings of International Symposium on Bio-Trace Elements 2002
  
  Pages: 69-70
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15209004
[Presentation] Elucidation of the mechanism involved in the induction of chemokine CCL4 expression by methylmercury2020
- Author(s)
  Kim M.S., Takahashi T., Toyama T., Naganuma A. and Hwang G.W.
- Organizer
  59th Annual Meeting of the Society of Toxicology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05714
[Presentation] A mechanism underlying methylmercury-induced TNF-α expression in mouse brain2020
- Author(s)
  Hoshi T., Toyama T., Naganuma A. and Hwang G.W.
- Organizer
  59th Annual Meeting of the Society of Toxicology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05714
[Presentation] メチル水銀によるマウス脳神経障害へのTNF受容体3の関与2020
- Author(s)
  角田洋平、外山喬士、永沼章、黄基旭
- Organizer
  日本薬学会第140年会
- Data Source
  KAKENHI-PROJECT-15H05714
[Presentation] メチル水銀によるASK1/p38経路を介したTNF-α発現誘導機構2020
- Author(s)
  星尚志、外山喬士、永沼章、黄基旭
- Organizer
  日本薬学会第140年会
- Data Source
  KAKENHI-PROJECT-15H05714
[Presentation] A mechanism underlying the enhancement of methylmercury toxicity through activation of transcription factor HOXB132020
- Author(s)
  Toyama T., Xu S., Nakano R., Hasegawa T., Naganuma A. and Hwang G.W.
- Organizer
  59th Annual Meeting of the Society of Toxicology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05714
[Presentation] RelB介したメチル水銀によるTNF-α発現誘導におけるtmRT1の役割2019
- Author(s)
  金子千華、外山喬士、永沼章、黄基旭
- Organizer
  第46回日本毒性学会学術年会
- Data Source
  KAKENHI-PROJECT-15H05714
[Presentation] Induction mechanism of TNF-α expression by methylmercury in microglial BV-2 cells2019
- Author(s)
  Hoshi T., Toyama T., Naganuma A. and Hwang G.W.
- Organizer
  The 39th Annual International Conference of Toxicology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05714
[Presentation] メチル水銀によるマウス脳内でのオンコスタチンM産生細胞の同定とその発現誘導機構の解析2019
- Author(s)
  星尚志、外山喬士、永沼章、黄基旭
- Organizer
  第58回日本薬学会東北支部大会
- Data Source
  KAKENHI-PROJECT-15H05714
[Presentation] メチル水銀によるtmRT1/RelB経路を介したTNF-αの発現誘導2019
- Author(s)
  金子千華、外山喬士、永沼章、黄基旭
- Organizer
  メタルバイオサイエンス研究会2019
- Data Source
  KAKENHI-PROJECT-15H05714
[Presentation] メチル水銀によるTNF受容体3を介した細胞死誘導機構の解明2019
- Author(s)
  角田洋平、外山喬士、星尚志、永沼章、黄基旭
- Organizer
  第46回日本毒性学会学術年会
- Data Source
  KAKENHI-PROJECT-15H05714
[Presentation] メチル水銀によるミクログリアにおけるオンコスタチンMの発現誘導機構2019
- Author(s)
  星尚志、外山喬士、永沼章、黄基旭
- Organizer
  フォーラム2019衛生薬学・環境トキシコロジー
- Data Source
  KAKENHI-PROJECT-15H05714
[Presentation] Mechanisms involved in the induction of TNF-α expression by methylmercury in mouse brain2019
- Author(s)
  Takashi Toyama, Takayuki Hoshi, Akira Naganuma and Gi-Wook Hwang
- Organizer
  Society of Toxicology 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05714
[Presentation] Elucidation of the mechanisms involved in methylmercury toxicity enhancement showed by the novel transcription factor tmRT12019
- Author(s)
  Toyama T., Osaki K., Hwang G.W. and Naganuma A.
- Organizer
  The 39th Annual International Conference of Toxicology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05714
[Presentation] Improvement of organotypic slice culture of mouse cerebral cortex to evaluate M1-microglial activation2019
- Author(s)
  Takayuki Hoshi, Takashi Toyama, Akira Naganuma, Gi-Wook Hwang
- Organizer
  Society of Toxicology 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05714
[Presentation] メチル水銀によるTNF受容体３を介した細胞死に関わる下流シグナル2019
- Author(s)
  角田洋平、外山喬士、永沼章、黄基旭
- Organizer
  メタルバイオサイエンス研究会2019
- Data Source
  KAKENHI-PROJECT-15H05714
[Presentation] メチル水銀投与マウス脳内でのTNF-α発現誘導に関わる細胞種の特定とその機構2019
- Author(s)
  星尚志、外山喬士、永沼章、黄基旭
- Organizer
  第46回日本毒性学会学術年会
- Data Source
  KAKENHI-PROJECT-15H05714
[Presentation] 改良型マウス大脳皮質スライス培養を用いたミクログリアを介したメチル水銀毒性発現機構の検討2019
- Author(s)
  星尚志、外山喬士、永沼章、黄基旭
- Organizer
  日本薬学会第139年会
- Data Source
  KAKENHI-PROJECT-15H05714
[Presentation] Methylmercury causes neuronal cell death by impairing mitochondrial function via TNF receptor X2019
- Author(s)
  Toyama T., Tsunoda Y., Hoshi T., Naganuma A. and Hwang G.W.
- Organizer
  SfRBM 26th Annual Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05714
[Presentation] メチル水銀によるオンコスタチンM発現誘導機構2019
- Author(s)
  黄唯屹、外山喬士、永沼章、黄基旭
- Organizer
  第46回日本毒性学会学術年会
- Data Source
  KAKENHI-PROJECT-15H05714
[Presentation] メチル水銀が示す神経細胞死誘導におけるTNF受容体3の関与2019
- Author(s)
  角田洋平、外山喬士、星尚志、永沼章、黄基旭
- Organizer
  日本薬学会第139年会
- Data Source
  KAKENHI-PROJECT-15H05714
[Presentation] 転写因子RelBの活性化を介したメチル水銀によるTNF-α発現誘導機構2019
- Author(s)
  金子千華、外山喬士、永沼章、黄基旭
- Organizer
  日本薬学会第139年会
- Data Source
  KAKENHI-PROJECT-15H05714
[Presentation] メチル水銀毒性増強作用を示すオンコスタチンMの増加に関わる分子機構2019
- Author(s)
  市川貴之、外山喬士、長谷川貴、永沼章、黄基旭
- Organizer
  第46回日本毒性学会学術年会
- Data Source
  KAKENHI-PROJECT-15H05714
[Presentation] メチル水銀によるOSM蛋白質レベルの増加メカニズム2019
- Author(s)
  外山喬士、長谷川貴、永沼章、黄基旭
- Organizer
  日本薬学会第139年会
- Data Source
  KAKENHI-PROJECT-15H05714
[Presentation] メチル水銀により神経幹細胞から放出される細胞増殖阻害因子の探索とその産生機構2019
- Author(s)
  外山喬士、永沼章、黄基旭
- Organizer
  フォーラム2019衛生薬学・環境トキシコロジー
- Data Source
  KAKENHI-PROJECT-15H05714
[Presentation] Involvement of TNF receptor 3 in the neuronal damage caused by methylmercury in mouse brain and its expected mechanisms2019
- Author(s)
  Tsunoda Y., Toyama T., Naganuma A. and Hwang G.W.
- Organizer
  2019 Japan/Korea Joint Symposium on Pharmaceutical Health Science and Environmental Toxicology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05714
[Presentation] マウス神経幹細胞におけるメチル水銀によるTNF受容体3を介した細胞死誘導機構2019
- Author(s)
  角田洋平、外山喬士、永沼章、黄基旭
- Organizer
  第58回日本薬学会東北支部大会
- Data Source
  KAKENHI-PROJECT-15H05714
[Presentation] メチル水銀毒性増強因子tmRT1を介したオンコスタチンMの発現誘導2019
- Author(s)
  外山喬士、黄唯迄、許思迪、永沼章、黄基旭
- Organizer
  メタルバイオサイエンス研究会2019
- Data Source
  KAKENHI-PROJECT-15H05714
[Presentation] Establishment of organotypic brain slice culture that can evaluate M1-microglial activation2019
- Author(s)
  Hoshi T., Toyama T., Naganuma A. and Hwang G.W.
- Organizer
  2019 Japan/Korea Joint Symposium on Pharmaceutical Health Science and Environmental Toxicology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05714
[Presentation] メチル水銀によるTNF受容体3を介したミトコンドリア機能障害2019
- Author(s)
  角田洋平、外山喬士、永沼章、黄基旭
- Organizer
  フォーラム2019衛生薬学・環境トキシコロジー
- Data Source
  KAKENHI-PROJECT-15H05714
[Presentation] Functional analysis of XRCC6, a tmRT1-binding protein in the tmRT1 activation by methylmercury2018
- Author(s)
  Yi-An Chen, Katsuhiro Osaki, Takashi Toyama, Akira Naganuma, Gi-Wook Hwang
- Organizer
  ASIATOX 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05714
[Presentation] メチル水銀による傷害性ミクログリアへの活性化を介した神経細胞損傷2018
- Author(s)
  星　尚志、外山　喬士、永沼　章、黄　基旭
- Organizer
  フォーラム2018衛生薬学・環境トキシコロジー
- Data Source
  KAKENHI-PROJECT-15H05714
[Presentation] A molecular mechanism for the induction of TNF-α expression by methylmercury in HEK293 cells2018
- Author(s)
  Chika Kaneko, Takashi Toyama, Akira Naganuma, Gi-Wook Hwang
- Organizer
  ASIATOX 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05714
[Presentation] メチル水銀によるRelBを介したTNF-α発現誘導機構2018
- Author(s)
  金子千華、外山喬士、永沼章、黄基旭
- Organizer
  メタルバイオサイエンス研究会 2018
- Data Source
  KAKENHI-PROJECT-15H05714
[Presentation] A novel mechanism involved in the induction of TNF-α expression by methylmercury2018
- Author(s)
  Chika Kaneko, Takashi Toyama, Akira Naganuma, Gi-Wook Hwang
- Organizer
  2018 Japan/Korea Joint Symposium on Pharmaceutical Health Science and Environmental Toxicology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05714
[Presentation] Identification of the cytotoxicity-inducing factors that are released from cells by methylmercury2018
- Author(s)
  Toyama T., Naganuma A. and Hwang G.W.
- Organizer
  57th Annual Meeting of the Society of Toxicology, San Antonio, USA
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05714
[Presentation] メチル水銀が示すマウス脳内での神経細胞死誘導作用へのTNF受容体3の関与2018
- Author(s)
  角田洋平、外山喬士、星尚志、永沼章、黄基旭
- Organizer
  第57会日本薬学会東北支部大会
- Data Source
  KAKENHI-PROJECT-15H05714
[Presentation] メチル水銀によるオンコスタチンMとTNF受容体3との結合促進機構の解析2018
- Author(s)
  長谷川貴、許思迪、外山喬士、永沼章、黄基旭
- Organizer
  日本薬学会第138年会
- Data Source
  KAKENHI-PROJECT-15H05714
[Presentation] メチル水銀によるミクログリアでのTNF-α発現誘導機構2018
- Author(s)
  外山喬士、星尚志、永沼章、黄基旭
- Organizer
  第4回次世代を担う若手のためのレキュラトリーサイエンスフォーラム
- Data Source
  KAKENHI-PROJECT-15H05714
[Presentation] メチル水銀が示すマウス脳神経障害とTNF受容体3との関わり2018
- Author(s)
  角田洋平、外山喬士、星尚志、永沼章、黄基旭
- Organizer
  メタルバイオサイエンス研究会 2018
- Data Source
  KAKENHI-PROJECT-15H05714
[Presentation] Elucidation of mechanisms underlying induction of tumor necrosis factor-α by methylmercury in mouse brain2018
- Author(s)
  Murakami S., Toyama T., Hoshi N., Naganuma A. and Hwang G.W
- Organizer
  57th Annual Meeting of the Society of Toxicology, San Antonio, USA
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05714
[Presentation] メチル水銀によるオンコスタチンM蛋白質の増加機構の解析2018
- Author(s)
  市川貴之、長谷川貴、外山喬士、永沼章、黄基旭
- Organizer
  第57会日本薬学会東北支部大会
- Data Source
  KAKENHI-PROJECT-15H05714
[Presentation] メチル水銀が示す神経毒性への傷害性ミクログリアの関与2018
- Author(s)
  星尚志、外山喬士、篠崎陽一、小泉修一、永沼章、黄基旭
- Organizer
  第45回日本毒性学会学術年会
- Data Source
  KAKENHI-PROJECT-15H05714
[Presentation] メチル水銀毒性増強に関わるtmRT1と結合する核内蛋白質の同定2018
- Author(s)
  陳奕安、秋山直行、大崎勝弘、外山喬士、永沼章、黄基旭
- Organizer
  メタルバイオサイエンス研究会 2018
- Data Source
  KAKENHI-PROJECT-15H05714
[Presentation] RIP1キナーゼを介したtmRT1のメチル水銀毒性増強作用2018
- Author(s)
  外山喬士、松田健人、永沼章、黄基旭
- Organizer
  メタルバイオサイエンス研究会 2018
- Data Source
  KAKENHI-PROJECT-15H05714
[Presentation] メチル水銀投与マウス脳内でのオンコスタチンM発現誘導機構の解明2018
- Author(s)
  黄　唯屹、外山　喬士、永沼　章、黄　基旭
- Organizer
  メタルバイオサイエンス研究会 2018
- Data Source
  KAKENHI-PROJECT-15H05714
[Presentation] メチル水銀によるTNF-α発現誘導に関わる新規メカニズム2018
- Author(s)
  金子千華、外山喬士、永沼章、黄基旭
- Organizer
  フォーラム2018衛生薬学・環境トキシコロジー
- Data Source
  KAKENHI-PROJECT-15H05714
[Presentation] Methylmercury induced neuronal cell death via M1-microglia activation2018
- Author(s)
  Takayuki Hoshi, Takashi Toyama, Akira Naganuma, Gi-Wook Hwang
- Organizer
  2018 Japan/Korea Joint Symposium on Pharmaceutical Health Science and Environmental Toxicology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05714
[Presentation] A mechanism involved in the induction of oncostatin M expression by methylmercury2018
- Author(s)
  Wei Yi Huang, Takashi Toyama, Takayuki Hoshi, Akira Naganuma, Gi-Wook Hwang
- Organizer
  2018 Japan/Korea Joint Symposium on Pharmaceutical Health Science and Environmental Toxicology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05714
[Presentation] メチル水銀によるミクログリアでのTNF-α発現誘導機構2018
- Author(s)
  星尚志、外山喬士、永沼章、黄基旭
- Organizer
  第4回次世代を担う若手のためのレキュラトリーサイエンスフォーラム
- Data Source
  KAKENHI-PROJECT-15H05714
[Presentation] メチル水銀によるオンコスタチンM蛋白質の増加機構の解析2018
- Author(s)
  市川貴之、長谷川貴、外山喬士、永沼章、黄基旭
- Organizer
  メタルバイオサイエンス研究会 2018
- Data Source
  KAKENHI-PROJECT-15H05714
[Presentation] Roles of the binding proteins of tmRT1, a novel transcription factor that involved in enhancement of methylmercury toxicity, in tmRT1 activation by methylmercury2018
- Author(s)
  Chen Y.A., Osaki K., Togashi Y., Toyama T., Hwang G.W. and Naganuma A.
- Organizer
  57th Annual Meeting of the Society of Toxicology, San Antonio, USA
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05714
[Presentation] TNF受容体3を介したメチル水銀によるマウス脳神経傷害作用2018
- Author(s)
  角田洋平、外山喬士、星尚志、永沼章、黄基旭
- Organizer
  フォーラム2018衛生薬学・環境トキシコロジー
- Data Source
  KAKENHI-PROJECT-15H05714
[Presentation] メチル水銀によるシステイン残基の修飾を介したtmRT1の活性化機構2018
- Author(s)
  二見叔亮、外山喬士、永沼章、黄基旭
- Organizer
  日本薬学会第138年会
- Data Source
  KAKENHI-PROJECT-15H05714
[Presentation] マウスの脳内でのメチル水銀によるTNF-α発現誘導機構の解析2018
- Author(s)
  星尚志、外山喬士、永沼章、黄基旭
- Organizer
  第57会日本薬学会東北支部大会
- Data Source
  KAKENHI-PROJECT-15H05714
[Presentation] メチル水銀によるTNF-αの発現誘導に関わる転写因子の同定2018
- Author(s)
  金子千華、外山喬士、野口拓也、松沢厚、永沼章、黄基旭
- Organizer
  第45回日本毒性学会学術年会
- Data Source
  KAKENHI-PROJECT-15H05714
[Presentation] メチル水銀によるマウス脳神経障害へのTNF受容体3の関与2018
- Author(s)
  外山喬士、戸田英汰、永沼章、黄基旭
- Organizer
  第45回日本毒性学会学術年会
- Data Source
  KAKENHI-PROJECT-15H05714
[Presentation] 大脳スライス培養系を用いたメチル水銀による神経傷害へのミクログリアの関与2018
- Author(s)
  星尚志、外山喬士、永沼章、黄基旭
- Organizer
  メタルバイオサイエンス研究会 2018
- Data Source
  KAKENHI-PROJECT-15H05714
[Presentation] Identification of cells involved in the induction of tumor necrosis factor-α expression by methylmercury in the mouse brain and its molecular mechanisms2018
- Author(s)
  Takayuki Hoshi, Takashi Toyama, Akira Naganuma, Gi-Wook Hwang
- Organizer
  2018 ISES-ISEE
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05714
[Presentation] tmRT1が示すメチル水銀毒性増強作用におけるRIP1の関与2018
- Author(s)
  外山喬士、松田健人、永沼章、黄基旭
- Organizer
  フォーラム2018衛生薬学・環境トキシコロジー
- Data Source
  KAKENHI-PROJECT-15H05714
[Presentation] 新規転写因子tmRT1の活性化によるメチル水銀毒性増強作用におけるXRCC6の役割2017
- Author(s)
  黄基旭、陳奕安、大崎勝弘、外山喬士、永沼章
- Organizer
  メタルバイオサイエンス研究会2017
- Data Source
  KAKENHI-PROJECT-15H05714
[Presentation] メチル水銀毒性増強に関わる転写因子tmRT1と結合する蛋白質の同定2017
- Author(s)
  冨樫佑太、大崎勝弘、陳奕安、外山喬士、永沼章、黄基旭
- Organizer
  フォーラム2017衛生薬学・環境トキシコロジー
- Data Source
  KAKENHI-PROJECT-15H05714
[Presentation] オンコスタチンMによるメチル水銀の細胞毒性増強に関わる分子機構2017
- Author(s)
  永沼章、許思迪、外山喬士、黄基旭
- Organizer
  メタルバイオサイエンス研究会2017
- Data Source
  KAKENHI-PROJECT-15H05714
[Presentation] メチル水銀によるFOXA1を介したケモカインCCL4の発現誘導機2017
- Author(s)
  渋井雅志、金ミンソク、永沼章、黄基旭
- Organizer
  日本薬学会第137回年会
- Place of Presentation
  仙台
- Year and Date
  2017-03-27
- Data Source
  KAKENHI-PROJECT-15H05714
[Presentation] Identification of a cytotoxic factor released from cells treated with methylmercury2017
- Author(s)
  Toyama T., Naganuma A. and Hwang G.W.
- Organizer
  The 12th International Conference and 5th Asian Congress on Environmental Mutagens, Incheon, Korea
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05714
[Presentation] The role of XRCC6 in activation of tmRT1 induced by methylmercury in HEK293 cells2017
- Author(s)
  Chen Y.A., Osaki K., Toyama T., Naganuma A. and Hwang G.W.
- Organizer
  The 12th International Conference and 5th Asian Congress on Environmental Mutagens, Incheon, Korea
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05714
[Presentation] メチル水銀投与マウスの脳内でのTNF-α発現誘導に関わる責任細胞の同定とその機構解析2017
- Author(s)
  星尚志、外山喬士、村上聡一、永沼章、黄基旭
- Organizer
  フォーラム2017衛生薬学・環境トキシコロジー
- Data Source
  KAKENHI-PROJECT-15H05714
[Presentation] メチル水銀によるTNF-α発現誘導に関わるTNF-αプロモーター領域の解析2017
- Author(s)
  金子千華、外山喬士、黄基旭、永沼章
- Organizer
  第44回日本毒性学会学術年会
- Data Source
  KAKENHI-PROJECT-15H05714
[Presentation] Analysis of tumor necrosis factor-α expression induced by methylmercury in mouse brain2017
- Author(s)
  Hoshi T., Toyama T., Murakami S., Naganuma A. and Hwang G.W.
- Organizer
  The 12th International Conference and 5th Asian Congress on Environmental Mutagens, Incheon, Korea
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05714
[Presentation] メチル水銀によるアポトーシス誘導における転写因子TCF3の役割2017
- Author(s)
  外山喬士、王妍コウ、永沼章、黄基旭
- Organizer
  第56回日本薬学会東北支部大会
- Data Source
  KAKENHI-PROJECT-15H05714
[Presentation] オンコスタチンMが示すメチル水銀毒性増強機構2017
- Author(s)
  許思迪、長谷川貴、永沼章、黄基旭
- Organizer
  日本薬学会第137回年会
- Place of Presentation
  仙台
- Year and Date
  2017-03-27
- Data Source
  KAKENHI-PROJECT-15H05714
[Presentation] メチル水銀毒性の増強に関わる転写因子 tmRT1と結合する蛋白質の探索とその役割の解明2017
- Author(s)
  陳奕安、大崎勝弘、外山喬士、黄基旭、永沼章
- Organizer
  第44回日本毒性学会学術年会
- Data Source
  KAKENHI-PROJECT-15H05714
[Presentation] Identification of the binding proteins of tmRT1, a novel transcription factor, involved in enhancement of methylmercury toxicity2017
- Author(s)
  Togashi Y., Osaki K., Chen Y. A., Toyama T., Naganuma A. and Hwang G.W.
- Organizer
  The 12th International Conference and 5th Asian Congress on Environmental Mutagens, Incheon, Korea
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05714
[Presentation] メチル水銀によるミクログリア細胞でのTNF-α発現誘導機構2017
- Author(s)
  黄基旭、村上聡一、外山喬士、永沼章
- Organizer
  第44回日本毒性学会学術年会
- Data Source
  KAKENHI-PROJECT-15H05714
[Presentation] メチル水銀により活性化される転写因子の同定およびその役割2017
- Author(s)
  王妍コウ、外山喬士、金ミンソク、黄基旭、永沼章
- Organizer
  日本薬学会第137回年会
- Place of Presentation
  仙台
- Year and Date
  2017-03-27
- Data Source
  KAKENHI-PROJECT-15H05714
[Presentation] Role of oncostatin M in methylmercury toxicity2017
- Author(s)
  Toda E., Xu S., Toyama T., Naganuma A., and Hwang G.W.
- Organizer
  The 12th International Conference and 5th Asian Congress on Environmental Mutagens, Incheon, Korea
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05714
[Presentation] メチル水銀によって活性化される新規転写因子tmRT1の結合蛋白質の解析2017
- Author(s)
  外山喬士、陳奕安、冨樫佑汰、大崎勝弘、永沼章、黄基旭
- Organizer
  メタルバイオサイエンス研究会2017
- Data Source
  KAKENHI-PROJECT-15H05714
[Presentation] Functional Analysis of tmRT1, a Novel Transcription Factor, in the Induction of TNF-αGene Expression by Methylmercury2017
- Author(s)
  N. Endo, A. Naganuma, G.W. Hwang
- Organizer
  56th Annual Meeting of the Society of Toxicology
- Place of Presentation
  Baltimore, USA
- Year and Date
  2017-03-14
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05714
[Presentation] メチル水銀投与マウス脳内でのTNF-α発現誘導機構2017
- Author(s)
  星尚志、外山喬士、村上聡一、永沼章、黄基旭
- Organizer
  第56回日本薬学会東北支部大会
- Data Source
  KAKENHI-PROJECT-15H05714
[Presentation] A mechanism for methylmercury induction of TNF-α in human TLR4-expressing HEK293 cells2017
- Author(s)
  Kaneko C., Toyama T., Fukagawa S., Noguchi T., Matsuzawa A., Naganuma A. and Hwang G.W.
- Organizer
  The 12th International Conference and 5th Asian Congress on Environmental Mutagens, Incheon, Korea
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05714
[Presentation] メチル水銀投与マウス脳内で活性化される転写因子の同定とその活性化機構2017
- Author(s)
  外山喬士、王妍コウ、金ミンソク、永沼章、黄基旭
- Organizer
  第44回日本毒性学会学術年会
- Data Source
  KAKENHI-PROJECT-15H05714
[Presentation] Methylmercury Selectively Induces the Expression of TNF-α in the Mouse Brain2017
- Author(s)
  Y. Iwai-Shimada, T. Takahashi, A. Naganuma, G.W. Hwang
- Organizer
  56th Annual Meeting of the Society of Toxicology
- Place of Presentation
  Baltimore, USA
- Year and Date
  2017-03-14
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05714
[Presentation] メチル水銀によるTNF-α発現誘導に関わる新規転写因子tmRT1の機能解析2017
- Author(s)
  遠藤直紀、小杉健太、外山喬士、永沼章、黄基旭
- Organizer
  メタルバイオサイエンス研究会2017
- Data Source
  KAKENHI-PROJECT-15H05714
[Presentation] tmRT1が示すメチル水銀毒性増強作用におけるアポトーシスの関与2017
- Author(s)
  松田健人、外山喬士、永沼章、黄基旭
- Organizer
  メタルバイオサイエンス研究会2017
- Data Source
  KAKENHI-PROJECT-15H05714
[Presentation] メチル水銀によるTNF-αの発現誘導機構2017
- Author(s)
  金子千華、外山喬士、深川隼、野口拓也、松沢厚、永沼章、黄基旭
- Organizer
  フォーラム2017衛生薬学・環境トキシコロジー
- Data Source
  KAKENHI-PROJECT-15H05714
[Presentation] メチル水銀投与マウス脳内でのTNF-α発現誘導およびその機構2017
- Author(s)
  外山喬士、村上聡一、黄基旭、永沼章
- Organizer
  日本薬学会第137回年会
- Place of Presentation
  仙台
- Year and Date
  2017-03-27
- Data Source
  KAKENHI-PROJECT-15H05714
[Presentation] メチル水銀による脳特異的なセクレトロビン3A1誘導とその機構解析2016
- Author(s)
  高橋　勉，趙　倩，齋藤隆寛，金ミンソク，黄　基旭，永沼　章
- Organizer
  平成27年度メチル水銀研究ミーティング
- Place of Presentation
  東京
- Year and Date
  2016-01-07
- Data Source
  KAKENHI-PROJECT-15H05714
[Presentation] メチル水銀によるTNF-α発現誘導に関与する新規転写因子tmRT1の機能解析2016
- Author(s)
  遠藤直紀 , 金子千華 , 黄基旭 , 永沼章
- Organizer
  第43回日本毒性学会学術年会
- Place of Presentation
  名古屋
- Year and Date
  2016-07-01
- Data Source
  KAKENHI-PROJECT-15H05714
[Presentation] メチル水銀によるオートファジー誘導機構の解析2016
- Author(s)
  長谷川　貴、松田　健人、永沼　章、黄　基旭
- Organizer
  日本薬学会第136年会
- Place of Presentation
  横浜
- Year and Date
  2016-03-29
- Data Source
  KAKENHI-PROJECT-15H05714
[Presentation] Role of MRTF, a novel transcription factor, in induction of TNF-α gene expression by methylmercury2016
- Author(s)
  Naoki Endo, Akira Naganuma and Gi-Wook Hwang
- Organizer
  55th Annual Meeting of the Society of Toxicology
- Place of Presentation
  New Orelans, USA
- Year and Date
  2016-03-14
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05714
[Presentation] Identification of the cytotoxic factor which is released from HEK293 cells treated with methylmercury2016
- Author(s)
  Takashi Toyama, Soichi Murakami, Gi-Wook Hwang, Akira Naganuma
- Organizer
  Japan/Korea Joint Symposium on Pharmaceutical Health Sciences and Environmental Toxicology
- Place of Presentation
  Tokyo
- Year and Date
  2016-09-10
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05714
[Presentation] オートファジー誘導へのメチル水銀の関与とその機構解析2016
- Author(s)
  外山喬士、長谷川貴、松田健人、黄基旭、永沼章
- Organizer
  平成28年度メチル水銀研究ミーティング
- Place of Presentation
  Tokyo
- Year and Date
  2016-12-26
- Invited
- Data Source
  KAKENHI-PROJECT-15H05714
[Presentation] メチル水銀により細胞外へ放出されてメチル水銀毒性を増強する因子の探索2016
- Author(s)
  外山喬士 , 村上聡一 , 小杉健太 , 黄基旭 , 永沼章
- Organizer
  第43回日本毒性学会学術年会
- Place of Presentation
  名古屋
- Year and Date
  2016-07-01
- Data Source
  KAKENHI-PROJECT-15H05714
[Presentation] 新規転写因子tmRT1を介したメチル水銀によるTNFa発現誘導機構2016
- Author(s)
  遠藤直紀、黄　基旭、永沼　章
- Organizer
  メタルバイオサイエンス研究会サテライト2016
- Place of Presentation
  静岡
- Year and Date
  2016-08-18
- Data Source
  KAKENHI-PROJECT-15H05714
[Presentation] Molecular mechanisms involved in enhancement of methylmercury toxicity by tmRT12016
- Author(s)
  Sidi Xu, Akira Naganuma, Gi-Wook Hwang
- Organizer
  Japan/Korea Joint Symposium on Pharmaceutical Health Sciences and Environmental Toxicology
- Place of Presentation
  Tokyo
- Year and Date
  2016-09-10
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05714
[Presentation] メチル水銀による脳特異的なケモカイン誘導とその機構解析2015
- Author(s)
  高橋　勉，金ミンソク，李　辰竜，黄　基旭，永沼　章
- Organizer
  メタルバイオサイエンス研究会2015
- Place of Presentation
  名古屋
- Year and Date
  2015-08-26
- Data Source
  KAKENHI-PROJECT-15H05714
[Presentation] Pyruvate incorporated into the mitochondria is involved in enhancement of methylmercury toxicity through mitochondrial membrane potential damage2015
- Author(s)
  Jin-Yong Lee, Yosuke Ishida, Akira Naganuma, Gi-Wook Hwang
- Organizer
  The 31th Annual Meeting of KSOT/KEMS
- Place of Presentation
  Seoul, Korea
- Year and Date
  2015-11-12
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05714
[Presentation] メチル水銀によるアポトーシス誘導におけるプトレシンの役割2015
- Author(s)
  佐藤昌幸、永沼　章、黄　基旭
- Organizer
  第４２回日本毒性学会学術年会
- Place of Presentation
  金沢
- Year and Date
  2015-06-30
- Data Source
  KAKENHI-PROJECT-15H05714
[Presentation] Methylmercury in breast milk of Japanese mothers and lactational exposure of their infants2015
- Author(s)
  Miyuki Iwai-Shimada, Hiroshi Satoh, Kunihiko Nakai, Nozomi Tatsuta, Katsuyuki Murata, Akira Naganuma, Hirokatsu Akagi
- Organizer
  12th International Conference on Mercury as a Global Pollutant
- Place of Presentation
  Jeju, Korea
- Year and Date
  2015-06-18
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05714
[Presentation] メチル水銀によるSCGB3A1発現誘導におけるNF-κBの関与2015
- Author(s)
  高橋　勉，趙　倩，金ミンソク，岩井美幸，黄　基旭，永沼　章
- Organizer
  フォーラム2015 衛生薬学・環境トキシコロジー
- Place of Presentation
  神戸
- Year and Date
  2015-09-01
- Data Source
  KAKENHI-PROJECT-15H05714
[Presentation] 胎児期の残留性有機汚染物質曝露と出生体重および発達との関連性2015
- Author(s)
  岩井美幸、龍田希、黒川修行、仲井邦彦、永沼章、佐藤洋
- Organizer
  第４２回日本毒性学会学術年会
- Place of Presentation
  金沢
- Year and Date
  2015-06-30
- Data Source
  KAKENHI-PROJECT-15H05714
[Presentation] The role of EGO complex in methylmercury-induced abnormal vacuolar morphology in yeast cells2015
- Author(s)
  Zhi-Ting Zhang, Akira Naganuma, Gi-Wook Hwang
- Organizer
  The 7th International Congress of Asian Society of Toxicology
- Place of Presentation
  Jeju, Korea
- Year and Date
  2015-06-24
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05714
[Presentation] Elucidating the role of HOXB13 in methylmercury toxicity by increase of TNF-α gene expression2015
- Author(s)
  Naoki Endo, Akira Naganuma, Gi-Wook Hwang
- Organizer
  The 7th International Congress of Asian Society of Toxicology
- Place of Presentation
  Jeju, Korea
- Year and Date
  2015-06-24
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05714
[Presentation] Exposure to methylmercury via breast milk in Japanese infants2015
- Author(s)
  Miyuki Iwai-Shimada, Hiroshi Satoh, Kunihiko Nakai, Nozomi Tatsuta, Katsuyuki Murata, Gi-Wook Hwang, Akira Naganuma, Hirokatsu Akagi
- Organizer
  The 7th International Congress of Asian Society of Toxicology
- Place of Presentation
  Jeju, Korea
- Year and Date
  2015-06-24
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05714
[Presentation] ポリアミン合成系によるメチル水銀毒性軽減機構の解析2014
- Author(s)
  佐藤昌幸、黄基旭、永沼章
- Organizer
  第53回日本薬学会東北支部大会
- Place of Presentation
  いわき市
- Year and Date
  2014-10-05
- Data Source
  KAKENHI-PROJECT-24249008
[Presentation] Brain-specific induction of expression of Ccl4 and Scgb3a1 by methylmercury in mice2014
- Author(s)
  Min-Seok Kim, Tsutomu Takahashi, Jin-Yong Lee, Gi-Wook Hwang, Akira Naganuma
- Organizer
  53th Annual Meeting of the Society of Toxicology
- Place of Presentation
  Phoenix (USA)
- Data Source
  KAKENHI-PROJECT-24249008
[Presentation] The function of TEX27 on reduction of methylmercury toxicity2013
- Author(s)
  Seong-Eun Oh, Gi-Wook Hwang, Akira Naganuma
- Organizer
  The XIII International Congress of Toxicology
- Place of Presentation
  Seoul（Korea）
- Data Source
  KAKENHI-PROJECT-24249008
[Presentation] メチル水銀によってマウス脳特異的に発現誘導される遺伝子群2013
- Author(s)
  金ミンソク、斉藤隆寛、高橋勉、李辰竜、黄基旭、永沼章
- Organizer
  第40回日本毒性学会学術年会
- Place of Presentation
  千葉市
- Data Source
  KAKENHI-PROJECT-24249008
[Presentation] ホメオボックス蛋白質HOX-B13が示すメチル水銀毒性増強におけるTNF-α の役割2013
- Author(s)
  仲野亮、福澤啓睦、黄基旭、永沼章
- Organizer
  第40回日本毒性学会学術年会
- Place of Presentation
  千葉市
- Data Source
  KAKENHI-PROJECT-24249008
[Presentation] Screenings for Proteins that Influence Sensitivity of Cells to Methylmercury2013
- Author(s)
  Akira Naganuma
- Organizer
  The XIII International Congress of Toxicology
- Place of Presentation
  Seoul（Korea）
- Invited
- Data Source
  KAKENHI-PROJECT-24249008
[Presentation] TNF-α/TNFR3シグナル伝達系を介したホメオボックス蛋白質HOXB13によるメチル水銀毒性増強機構2013
- Author(s)
  仲野亮、黄基旭、永沼章
- Organizer
  フォーラム2013：衛生薬学・環境トキシコロジー
- Place of Presentation
  福岡市
- Data Source
  KAKENHI-PROJECT-24249008
[Presentation] Methylmercury Induces a Brain-Specific Increase in Chemokine CCL3 and CCL4 Expression in Mice2013
- Author(s)
  Min-Seok Kim, Jin-Yong Lee, Tsutomu Takahashi, Gi-Wook Hwang, Akira Naganuma
- Organizer
  The XIII International Congress of Toxicology
- Place of Presentation
  Seoul（Korea）
- Data Source
  KAKENHI-PROJECT-24249008
[Presentation] Molecular mechanism by which homeobox protein HOX-B13 augments methylmercury toxicity in HEK293 cells2013
- Author(s)
  Ryo Nakano, Gi-Wook Hwang, Akira Naganuma
- Organizer
  The XIII International Congress of Toxicology
- Place of Presentation
  Seoul（Korea）
- Data Source
  KAKENHI-PROJECT-24249008
[Presentation] 新規カドミウム毒性軽減因子としてのユビキチンリガーゼFBXO6の機能解析2012
- Author(s)
  杜可、永沼章
- Organizer
  日本薬学会第132年会
- Place of Presentation
  札幌(招待講演)
- Year and Date
  2012-03-31
- Data Source
  KAKENHI-PROJECT-19101003
[Presentation] メチル水銀によるケモカイン発現誘導におけるNF-kBの関与2012
- Author(s)
  金ミンソク、永沼章
- Organizer
  日本薬学会第132年会
- Place of Presentation
  札幌
- Year and Date
  2012-03-31
- Data Source
  KAKENHI-PROJECT-19101003
[Presentation] DNA microarray analysis of gene expression profiling in the cerebellum of mice treated with methylmercury2012
- Author(s)
  Lee J.Y., Naganuma A.
- Organizer
  51th Annual Meeting of the Society of Toxicology
- Place of Presentation
  San Francisco (USA)
- Year and Date
  2012-03-13
- Data Source
  KAKENHI-PROJECT-19101003
[Presentation] ピルビン酸によるメチル水銀毒性増強作用とミトコンドリア機能障害との関係2011
- Author(s)
  李辰竜、永沼章
- Organizer
  平成23年度メチル水銀研究ミーティング
- Place of Presentation
  東京
- Year and Date
  2011-12-21
- Data Source
  KAKENHI-PROJECT-19101003
[Presentation] メチル水銀毒性軽減蛋白質TEX27のメチル水銀による核移行2011
- Author(s)
  呉成恩、永沼章
- Organizer
  平成23年度メチル水銀研究ミーティング
- Place of Presentation
  東京
- Year and Date
  2011-12-21
- Data Source
  KAKENHI-PROJECT-19101003
[Presentation] 新規メチル水銀毒性増強機構としての細胞内蛋白質輸送系の役割2011
- Author(s)
  石川円華、黄基旭、永沼章
- Organizer
  第50回日本薬学会東北支部大会
- Place of Presentation
  仙台
- Year and Date
  2011-11-30
- Data Source
  KAKENHI-PROJECT-19101003
[Presentation] メチル水銀によるミトコンドリア機能障害に対するピルビン酸の増強作用2011
- Author(s)
  李辰竜、黄基旭、永沼章
- Organizer
  フォーラム2011:衛生薬学・環境トキシコロジー
- Place of Presentation
  金沢
- Year and Date
  2011-10-27
- Data Source
  KAKENHI-PROJECT-19101003
[Presentation] Role of pyruvate in mitochondrial impairment by methylmercury toxicity2011
- Author(s)
  Lee J.Y., Naganuma A.
- Organizer
  The 27^<th> Annual Meeting of KSOT
- Place of Presentation
  Jeju (Korea)
- Year and Date
  2011-11-04
- Data Source
  KAKENHI-PROJECT-19101003
[Presentation] 熱ショック転写因子HSF1が示すメチル水銀毒性軽減機構の解析2011
- Author(s)
  領家克典、黄基旭、永沼章
- Organizer
  第10回次世代を担う若手ファーマ・バイオフォーラム2011
- Place of Presentation
  仙台
- Year and Date
  2011-10-08
- Data Source
  KAKENHI-PROJECT-19101003
[Presentation] Identification of new factors involved in reduction of methylmercury toxicity using whole-genome siRNA library2011
- Author(s)
  Oh S.E., Naganuma A.
- Organizer
  The 27^<th> Annual Meeting of KSOT
- Place of Presentation
  Jeju (Korea)
- Year and Date
  2011-11-04
- Data Source
  KAKENHI-PROJECT-19101003
[Presentation] 熱ショック転写因子HSF1が示すメチル水銀毒性軽減機構の解析2011
- Author(s)
  領家克典、永沼章
- Organizer
  第10回次世代を担う若手ファーマ・バイオフォーラム
- Place of Presentation
  仙台
- Year and Date
  2011-10-08
- Data Source
  KAKENHI-PROJECT-19101003
[Presentation] メチル水銀による熱ショック転写因子HSF1の活性化およびそれによるメチル水銀毒性軽減機構の解析2011
- Author(s)
  領家克典、永沼章
- Organizer
  フォーラム2011:衛生薬学・環境トキシコロジー
- Place of Presentation
  金沢
- Year and Date
  2011-10-27
- Data Source
  KAKENHI-PROJECT-19101003
[Presentation] 機能未知蛋白質TEX27が示すメチル水銀毒性軽減作用の機構2011
- Author(s)
  呉成恩、黄基旭、永沼章
- Organizer
  第38回日本トキシコロジー学会
- Place of Presentation
  横浜
- Year and Date
  2011-07-11
- Data Source
  KAKENHI-PROJECT-19101003
[Presentation] 薬毒物に対する生体内防御機構に関する研究2011
- Author(s)
  永沼章
- Organizer
  第38回日本トキシコロジー学会
- Place of Presentation
  横浜(招待講演)
- Year and Date
  2011-07-11
- Data Source
  KAKENHI-PROJECT-19101003
[Presentation] 機能未知蛋白質TEX27の細胞内分布とメチル水銀毒性との関わり2011
- Author(s)
  呉成恩、永沼章
- Organizer
  フォーラム2011:衛生薬学・環境トキシコロジー
- Place of Presentation
  金沢
- Year and Date
  2011-10-27
- Data Source
  KAKENHI-PROJECT-19101003
[Presentation] パルミチン酸転移酵Akr1が示すメチル水銀毒性軽減作用に関わる細胞内因子の同定およびその役割2011
- Author(s)
  黄基旭、永沼章
- Organizer
  第8回メタロチオネインおよびメタルバイオサイエンス研究会
- Place of Presentation
  名古屋
- Year and Date
  2011-12-09
- Data Source
  KAKENHI-PROJECT-19101003
[Presentation] マウスにおけるメチル水銀によるケモカインリガンドの発現誘導2011
- Author(s)
  李辰竜、永沼章
- Organizer
  第8回メタロチオネインおよびメタルバイオサイエンス研究会
- Place of Presentation
  名古屋
- Year and Date
  2011-12-09
- Data Source
  KAKENHI-PROJECT-19101003
[Presentation] メチル水銀によるミトコンドリア機能障害に与えるピルビン酸の影響2011
- Author(s)
  李辰竜、永沼章
- Organizer
  第38回日本トキシコロジー学会
- Place of Presentation
  横浜
- Year and Date
  2011-07-11
- Data Source
  KAKENHI-PROJECT-19101003
[Presentation] 薬毒物に対する生体内防御機構に関する研究2011
- Author(s)
  永沼章
- Organizer
  第38回日本トキシコロジー学会
- Place of Presentation
  横浜
- Year and Date
  2011-07-11
- Data Source
  KAKENHI-PROJECT-19101003
[Presentation] カドミウムによるアポトーシスにおけるユビキチンリガーゼFBXO6の関与2011
- Author(s)
  杜可、永沼章
- Organizer
  第38回日本トキシコロジー学会
- Place of Presentation
  横浜
- Year and Date
  2011-07-11
- Data Source
  KAKENHI-PROJECT-19101003
[Presentation] Overexpression of Rad23 confers resistance to methylmercury in yeast cells via inhibition of degradation of Png2010
- Author(s)
  Hwang, G. W., and Naganuma, A.
- Organizer
  XII International Congress of Toxicology
- Place of Presentation
  Barcelona(Spain)
- Year and Date
  2010-07-22
- Data Source
  KAKENHI-PROJECT-19101003
[Presentation] 新規メチル水銀毒性軽減因子TEX27の機能解析2010
- Author(s)
  呉成恩、黄基旭、永沼章
- Organizer
  フォーラム2010;衛生薬学・環境トキシコロジー
- Place of Presentation
  東京
- Year and Date
  2010-09-09
- Data Source
  KAKENHI-PROJECT-19101003
[Presentation] メチル水銀毒性発現に関わる遺伝子群の合成二本鎖siRNAライブラリーを用いた検索2010
- Author(s)
  呉成恩、永沼章
- Organizer
  日本薬学会第130年会
- Place of Presentation
  岡山
- Year and Date
  2010-03-30
- Data Source
  KAKENHI-PROJECT-19101003
[Presentation] ピルビン酸によるメチル水銀毒性増強作用における活性酸素種の関与2010
- Author(s)
  李辰竜、永沼章
- Organizer
  日本薬学会第130年会
- Place of Presentation
  岡山
- Year and Date
  2010-03-30
- Data Source
  KAKENHI-PROJECT-19101003
[Presentation] パルミチン酸転移酵素Akr1によるメチル水銀毒性軽減におけるMeh1の関与2010
- Author(s)
  伊藤悠一、黄基旭、疋田晃典、永沼章
- Organizer
  フォーラム2010:衛生薬学・環境トキシコロジー
- Place of Presentation
  東京
- Year and Date
  2010-09-09
- Data Source
  KAKENHI-PROJECT-19101003
[Presentation] メチル水銀感受性決定因子としての脱ユビキチン化酵素Ubp6の役割2010
- Author(s)
  木村幸由, 黄基旭, 永沼章
- Organizer
  日本薬学会第130年会
- Place of Presentation
  岡山
- Year and Date
  2010-03-30
- Data Source
  KAKENHI-PROJECT-19101003
[Presentation] Overexpression of Cdc34 or Ubc4, ubiquitin-conjugating enzymes, confer resistance to cadmium through different mechanisms in yeast cells2010
- Author(s)
  黄基旭, 永沼章
- Organizer
  49th Annual Meeting of the Society of Toxicology
- Place of Presentation
  Salt Lake City(USA)
- Year and Date
  2010-03-09
- Data Source
  KAKENHI-PROJECT-19101003
[Presentation] Involvement of Rip 1, a component of electron transport system complex III, in methylmercury toxicity in budding yeast2010
- Author(s)
  李辰竜, 永沼章
- Organizer
  49th Annual Meeting of the Society of Toxicology
- Place of Presentation
  Salt Lake City(USA)
- Year and Date
  2010-03-09
- Data Source
  KAKENHI-PROJECT-19101003
[Presentation] リソソームへの細胞内輸送系を介してメチル水銀毒性増強に関与する因子の同定2009
- Author(s)
  石川円華, 永沼章
- Organizer
  フォーラム2009:衛生薬学・環境トキシコロジー
- Place of Presentation
  沖縄
- Year and Date
  2009-11-05
- Data Source
  KAKENHI-PROJECT-19101003
[Presentation] メチル水銀毒性発現におけるユビキチン前駆体Ubi4の役割2009
- Author(s)
  黄基旭、永沼章
- Organizer
  第36回日本トキシコロジー学会学術年会
- Place of Presentation
  盛岡
- Year and Date
  2009-07-07
- Data Source
  KAKENHI-PROJECT-19101003
[Presentation] メチル水銀感受性決定における脱ユビキチン化酵素Ubp6の役割2009
- Author(s)
  木村幸由、永沼章
- Organizer
  第48回日本薬学会東北支部大会
- Place of Presentation
  仙台
- Year and Date
  2009-10-18
- Data Source
  KAKENHI-PROJECT-19101003
[Presentation] ユビキチン前駆体Ubi4によるメチル水銀毒性増強機構2009
- Author(s)
  黄基旭、永沼章
- Organizer
  メタロチオネインおよびメタルバイオサイエンス研究会
- Place of Presentation
  東京
- Year and Date
  2009-10-16
- Data Source
  KAKENHI-PROJECT-19101003
[Presentation] 神経芽種細胞でのピルビン酸によるメチル水銀毒性増強作用2009
- Author(s)
  李辰竜, 永沼章
- Organizer
  フォーラム2009:衛生薬学・環境トキシコロジー
- Place of Presentation
  沖縄
- Year and Date
  2009-11-05
- Data Source
  KAKENHI-PROJECT-19101003
[Presentation] メチル水銀毒性増強蛋白質Whi2のプロテアソームでの分解調節におけるUbp6およびRpn10の役割2009
- Author(s)
  木村幸由、永沼章
- Organizer
  メタロチオネインおよびメタルバイオサイエンス研究会
- Place of Presentation
  東京
- Year and Date
  2009-10-16
- Data Source
  KAKENHI-PROJECT-19101003
[Presentation] メチル水銀毒性とユビキチン転移酵素群との関わり2009
- Author(s)
  松山藤王、永沼章
- Organizer
  第48回日本薬学会東北支部大会
- Place of Presentation
  仙台
- Year and Date
  2009-10-18
- Data Source
  KAKENHI-PROJECT-19101003
[Presentation] Idenfication and functional analysis of novel genes involved in methylm ercury toxicity2009
- Author(s)
  黄基旭, 永沼章
- Organizer
  KSEH International Conference 2009
- Place of Presentation
  Daegu(Korea)
- Year and Date
  2009-06-05
- Data Source
  KAKENHI-PROJECT-19101003
[Presentation] Overexpression of Cdc34 confers resistance to cadmium in yeast cells2009
- Author(s)
  黄基旭, 永沼章
- Organizer
  5^<th> International Congress of Asian Society of Toxicology
- Place of Presentation
  Taipei(Taiwan)
- Year and Date
  2009-07-12
- Data Source
  KAKENHI-PROJECT-19101003
[Presentation] 複数のユビキチン転移酵素分子種間の相互作用によるメチル水銀感受性に制御2009
- Author(s)
  松山藤王, 永沼章
- Organizer
  フォーラム2009:衛生薬学・環境トキシコロジー
- Place of Presentation
  沖縄
- Year and Date
  2009-11-05
- Data Source
  KAKENHI-PROJECT-19101003
[Presentation] ユビキチン・プロテアソームシステムが関わるメチル水銀感受性決定機構2008
- Author(s)
  永沼章
- Organizer
  第78回日本衛生学会総会
- Place of Presentation
  熊本
- Year and Date
  2008-03-29
- Data Source
  KAKENHI-PROJECT-19101003
[Presentation] メチル水銀感受性に決定におけるユビキチン転移酵素分子種問相互作用の関与2008
- Author(s)
  松山藤王, 黄基旭, 永沼章
- Organizer
  フォーラム2008 : 衛生薬学・環境トキシコロジー
- Place of Presentation
  熊本
- Year and Date
  2008-10-17
- Data Source
  KAKENHI-PROJECT-19101003
[Presentation] 酵母におけるAkr1によるMeh1のパルミチン酸化を介したメチル水銀毒性軽減作用に関わる分子機構の解明
- Author(s)
  永沼章
- Organizer
  第39回日本毒性学会学術年会
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-24249008
[Presentation] メチル水銀毒性発現における機能未知蛋白質TEX27の役割
- Author(s)
  永沼　章
- Organizer
  第2回重金属毒性機構解明に関する研究会
- Place of Presentation
  十和田
- Data Source
  KAKENHI-PROJECT-24249008
[Presentation] HOXB13が示すメチル水銀毒性増強作用の分子機構解析
- Author(s)
  永沼章
- Organizer
  第39回日本毒性学会学術年会
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-24249008
[Presentation] Brain-specific expression of chemokines by methylmercury in mice
- Author(s)
  永沼章
- Organizer
  The 6th International Congress of Asian Society of Toxicology
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-24249008
[Presentation] ホメオボックス蛋白質HOX-B13 が示すメチル水銀毒性増強作用の機構解析
- Author(s)
  永沼　章
- Organizer
  第12回分子予防環境医学研究会年会
- Place of Presentation
  筑波
- Data Source
  KAKENHI-PROJECT-24249008
[Presentation] The palmitoylation of Meh1, a component of EGO complex, has an important role in the reduction of methylmercury toxicity in budding yeast
- Author(s)
  永沼　章
- Organizer
  52th Annual Meeting of the Society of Toxicology
- Place of Presentation
  San Antonio, USA
- Data Source
  KAKENHI-PROJECT-24249008
[Presentation] The molecular mechanism underlying the reduction of methylmercury toxicity through the palmioylation of Meh1 by Akr1 in budding yeast
- Author(s)
  永沼章
- Organizer
  The 6th International Congress of Asian Society of Toxicology
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-24249008
[Presentation] メチル水銀によってマウスの脳に特異的に発現誘導されるケモカイン
- Author(s)
  永沼章
- Organizer
  第39回日本毒性学会学術年会
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-24249008
[Presentation] メチル水銀毒性発現における細胞内ポリアミン代謝系の関与
- Author(s)
  佐藤昌幸, 永沼章, 黄基旭
- Organizer
  日本薬学会第135年会
- Place of Presentation
  神戸市
- Year and Date
  2015-03-26 – 2015-03-28
- Data Source
  KAKENHI-PROJECT-24249008
[Presentation] Ego complex のメチル水銀毒性軽減作用におけるMeh1 パルミチン酸化の関与
- Author(s)
  永沼章
- Organizer
  第51回日本薬学会東北支部大会
- Place of Presentation
  青森
- Data Source
  KAKENHI-PROJECT-24249008
[Presentation] マウス脳神経由来細胞におけるメチル水銀によるケモカインCCL4の発現誘導
- Author(s)
  金ミンソク、李辰竜、黄基旭、高橋勉、永沼章
- Organizer
  第52回日本薬学会東北支部大会
- Place of Presentation
  仙台市
- Data Source
  KAKENHI-PROJECT-24249008
[Presentation] メチル水銀によってマウス脳組織中で発現誘導されるサイトカイン
- Author(s)
  岩井美幸、釋氏佑紀奈、金ミンソク、黄基旭、高橋勉、永沼章
- Organizer
  第41回日本毒性学会学術年会
- Place of Presentation
  神戸市
- Year and Date
  2014-07-02 – 2014-07-04
- Data Source
  KAKENHI-PROJECT-26550037

1. MIURA Nobuhiko (20229644)

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NAGANUMA Akira 永沼 章

永沼 彰 ナガヌマ アキラ

永沼 章 ナガヌマ アキラ

Research Projects

Research Products

Co-Researchers

Molecular mechanism for toxic effect of methylmercuryPrincipal Investigator

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Brain selective expression of chemokines by methylmercuryPrincipal Investigator

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Explanation of the mechanism that influence the cell sensitivity to the toxicity of methylmercuryPrincipal Investigator

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MVB sorting system as a novel defense mechanism against toxicity of cadmiumPrincipal Investigator

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酸化ストレスに対する防御機構としてのMVBソーティングシステムPrincipal Investigator

Principal Investigator

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Cellular Systems Involved in Development and Regulation of Toxicity of MethylmercuryPrincipal Investigator

Principal Investigator

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siRNAによる遺伝子ノックダウン法を利用したメチル水銀感受性決定遺伝子の検索Principal Investigator

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siRNA法による全メタロチオネイン分子種発現抑制細胞の作成Principal Investigator

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メタロチオネインのアミノ酸置換が引き起こす影響Principal Investigator

Principal Investigator

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Studies on mechanism of toxicity of methylmercuryPrincipal Investigator

Principal Investigator

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メタロチオネインの遺伝子多型が引き起こす生育障害Principal Investigator

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シスプラチンの細胞毒性発現に関与する蛋白質の同定とその機能解析Principal Investigator

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Project Period (FY)

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Review Section

Research Institution

重金属中毒学のパラダイムシフト

Principal Investigator

NAGANUMA Akira 永沼章

永沼彰ナガヌマアキラ

永沼章ナガヌマアキラ