KOHNO Nobuoki 河野修興

Researcher Number	80215194
Other IDs
External Links
Affiliation (based on the past Project Information) *help	2016: 広島大学, 医歯薬保健学研究院(医), 教授 2012 – 2015: 広島大学, 大学院医歯薬保健学研究院, 教授 2013: 広島大学, 医歯薬保健学研究院(医), 教授 2011: 広島大学, 大学院医歯薬学総合研究科, 教授 2010: 広島大学, 大学院・医歯薬総合研究科, 教授 … More 2009: 広島大学, 医歯薬学総合研究科, 教授 2002 – 2009: 広島大学, 大学院・医歯薬学総合研究科, 教授 2007: 広島大学, 医歯薬学総合研究科, 教授 2006: Hiroshima University, Graduate School of Biomedical Sciences, Professor, 大学院医歯薬学総合研究科, 教授 2000 – 2001: HIROSHIMA UNIVERSITY, FACULTY OF MEDICINE, PROFESSOR, 医学部, 教授 1993 – 2000: Ehime University school of medicine, Lecturer, 医学部・附属病院, 講師 1994: Ehime Univ.Hospital, Lecturer, 医学部・付属病院, 講師 1994: 愛媛大学, 医学部附属病院, 講師 1992: 愛媛大学, 医学部附属病院, 講師 1990 – 1991: 愛媛大学, 医学部・附属病院, 講師 Less
Review Section/Research Field	Principal Investigator Respiratory organ internal medicine / Respiratory organ internal medicine / 内科学一般 Except Principal Investigator Respiratory organ internal medicine / Respiratory organ internal medicine
Keywords	Principal Investigator KL-6 / MUC1 / 肺癌 / 間質性肺炎 / モノクローナル抗体 / tandem repeat / lung cancer / ECLIA / CAIMAN / 予後因子 … More / 血清マーカー / PEP-76 / monoclonal antibody / 分子標的治療薬 / マイクロアレイ / 人種差 / バイオマーカー / primates / embryo lung / MUC1 polymorphism / prognostic factor / idiopathic interstitial pneumonia / アポトーシス / ヒト肺胞上皮細胞 / 線維芽細胞 / サイトカイン / Protease / 肺胞II型上皮 / MUCl / 特発性間質性 / 突発性間質性肺炎 / 霊長類 / 胎児肺 / MUC1多型 / 特発性間質性肺炎 / interstitial pneumonitis / electrochemiluminescence immunoassay / serum marker / MUC1 mucin / 電気化学発光 / ECL1A / MUCIムチン / 電機化学発光免疫測定法 / 電機化学発光免疫測定 / MUC1ムチン / antibody supplement therapy / chimera antibody / human monoclonal antibody / mouse monoclonal antibody / Lung Cancer / Muc1 / 抗体補充療法 / キメラ抗体 / ヒトモノクローナル抗体 / マウスモノクローナル抗体 / ANTI-MUC1 NATURAL AUTOANYTIBODY / PROGNOSTIC FACTOR / NON-SMALL CELL LUNG CANCER / LUNG CANCER / 抗MUC1抗体 / 自己抗体 / 抗MUC1自己抗体 / 非小細胞肺癌 / EK-7 antibody / interstitial pneumoitis / KL-6 sub-molecules / クラスター9 / ムチン / HK-7抗体 / KL-6亜分子 / cell adhesion / growth inhibition / breast cancer / differentiation / モノクロ-ナル抗体 / エストロ-ゲン・リセプタ- / インテグリン / 分化 / 細胞接着 / 増殖抑制 / 乳癌細胞 / 分化誘導 / SNP / 糖鎖 / ゲノム / 医療・福祉 / 薬剤性肺障害 / 呼吸器病学 / TypeIV collagen7S / PIIIP / KLー6抗原 / 血清マ-カ- … More Except Principal Investigator サイトカイン / 気管支喘息 / 肺線維症 / bronchial asthma / cytokine / 好酸球 / 肺癌 / KL-6 / RNA interference / Gene therapy / Fibrinolytic system / Pulmonary fibrosis / RNA干渉 / 遺伝子治療 / 線溶系 / remodeling / pulmonary fibrosis / interferon / T cells / fibroblast / リモデリング / インターフェロン / T細胞 / 線維芽細胞 / interleukin / eosinophil / 悪性中皮腫 / 転写因子 / IL-10 / IL-12 / SOCS / インターロイキン / Interleukin-5 / Cytokine / Bronchoalveolar lavage / Thromboxane A_2 / Bronchial asthma / Murine model / Eosinophil / 受身移入実験 / ヘルパーT細胞 / T細胞クローン / インターロイキン5 / 気管支肺胞洗浄 / トロンボキサンA2 / マウスモデル / 肺がん / 人種差 / バイオマーカー / ムチン / 慢性閉塞性肺疾患 / シメチジン / 癌転移抑制遺伝子 / 縦隔リンパ節転移 / 成人呼吸促迫症候群 / 汎発性血管内凝固症候群 / セレクチン / 急性呼吸窮迫症候群 / MUC1ムチン / PIP(3、4、5)_3 / PInsP(3、4)_2 / イノシトール / 細胞増殖抑制 / 細胞増殖 / ホスファチジルイノシトール / イノシトールポリリン酸 Less

国際共同研究による間質性肺炎の新規バイオマーカーの開発と創薬の試みPrincipal Investigator
- Principal Investigator
  
  河野修興
- Project Period (FY)
  2013 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Hiroshima University
Anti KL-6 antibody enhances the effects of molecular targeted drugPrincipal Investigator
- Principal Investigator
  
  KOHNO Nobuoki
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Hiroshima University
The elucidation of an ethnic difference of lung cancer and the development of a new therapy
- Principal Investigator
  
  ISHIKAWA Nobuhisa
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Hiroshima University
Comparative studies of a clinical features and genomic analysis in patients with interstitial lung disease and drug induced lung injuryPrincipal Investigator
- Principal Investigator
  
  KOHNO Nobuoki
- Project Period (FY)
  2007 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Hiroshima University
Clinicopathological role of kl-6/muc1 with selectin ligand
- Principal Investigator
  
  YOKOYAMA Akihito
- Project Period (FY)
  2007 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Kochi University
Experimental investigation for the development of therapeutic approaches to inhibit metastasis to mediastinal lymph node in lung cancer
- Principal Investigator
  
  KONDOH Tomohiro
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Hiroshima University
Development of gene therapy utilizing fibrinolytic system for pulmonary fibrosis
- Principal Investigator
  
  HATTORI Noboru
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  HIROSHIMA UNIVERSITY
Regulatory mechanisms for lung and airway fibrosis
- Principal Investigator
  
  YOKOYAMA Akihito
- Project Period (FY)
  2004 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Hiroshima University
The Study on KL-6 as Morbidity Ornamentation Factor and Prognosis Factor of Idiopathic Interstitial Pneumonia.Principal Investigator
- Principal Investigator
  
  KOHNO Nobuoki
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  HIROSHIMA UNIVERSITY
The Establishment of KL-6 Associated New Serum Markers Using High Sensitive Electrochemiluminescence Immunoassay.Principal Investigator
- Principal Investigator
  
  KOHNO Nobuoki
- Project Period (FY)
  2001 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  HIROSHIMA UNIVERSITY
Approaches to the pathogenesis of bronchial asthma
- Principal Investigator
  
  YOKOYAMA Akihito
- Project Period (FY)
  2001 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  HIROSHIMA UNIVERSIlY
  Ehime University
DEVELOPMENT OF A LUNG CANCER TREATMENT USING ANTI-KL-6/MUC1 MULTI-MONOCLONAL ANTIBODIESPrincipal Investigator
- Principal Investigator
  
  KOHNO Nobuoki
- Project Period (FY)
  1998 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  HIROSHIMA UNIVERSITY
  Ehime University
Clinical Significance of Anti-MUC1 Natural Autoantibody in Sera from Patients with Lung CancerPrincipal Investigator
- Principal Investigator
  
  KOHNO Nobuoki
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  EHIME UNIVERSITY
イノシトール類による細胞の増殖ないし抑制作用の研究
- Principal Investigator
  
  尾崎庄一郎
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Ehime University
Screening of new KL-6-associated mucins useful in clinical diagnosis of interstitial pneumonitisPrincipal Investigator
- Principal Investigator
  
  KOHNO Nobuoki
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  EHIME UNIVERSITY
Murine models of pulmonary diseases induced by adoptive transfer of T cell clones.
- Principal Investigator
  
  YOKOYAMA Akihito
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Ehime University
Differentiation Induction of a Cell Line with a Monoclonal AntibodyPrincipal Investigator
- Principal Investigator
  
  KOHNO Nobuoki
- Project Period (FY)
  1991 – 1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  内科学一般
- Research Institution
  Ehime University School of Medicine
間質性肺炎における血清中ムチン型糖蛋白(KLー6抗原)の臨床的有用性に関する研究Principal Investigator
- Principal Investigator
  
  河野修興
- Project Period (FY)
  1990
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Ehime University

[Book] がんの浸潤・転移2011
- Author(s)
  石川暢久，河野修興
- Total Pages
  241
- Publisher
  南山堂
- Data Source
  KAKENHI-PROJECT-23659433
[Book] 間質性肺疾患診療マニュアル2010
- Author(s)
  石川暢久, 河野修興
- Total Pages
  329
- Publisher
  KL-6
- Data Source
  KAKENHI-PROJECT-20590924
[Book] KL-6.間質性肺疾患診療マニュアル2010
- Author(s)
  石川暢久, 河野修興
- Publisher
  南江堂
- Data Source
  KAKENHI-PROJECT-20590924
[Book] がん化学療法・分子標的治療 update2009
- Author(s)
  石川暢久, 河野修興
- Total Pages
  736
- Publisher
  中外医学社
- Data Source
  KAKENHI-PROJECT-19390224
[Book] 肺毒性・心毒性.癌化学療法update 2010-20112009
- Author(s)
  石川暢久, 河野修興
- Publisher
  中外医薬社
- Data Source
  KAKENHI-PROJECT-20590924
[Book] んがで読み解く呼吸器症例1002009
- Author(s)
  河野修興監修,横山彰仁,森山美智子,服部登(編集)
- Total Pages
  284
- Publisher
  メディカルビュー社
- Data Source
  KAKENHI-PROJECT-19390224
[Book] がん化学療法・分子標的治療 update2009
- Author(s)
  石川暢久, 河野修興
- Total Pages
  736
- Publisher
  中外医学社
- Data Source
  KAKENHI-PROJECT-20590924
[Book] BAL法の臨床応用. 気管支肺胞洗浄(BAL)の手引き2008
- Author(s)
  服部登, 河野修興監修
- Publisher
  京誠堂出版社
- Data Source
  KAKENHI-PROJECT-19390224
[Book] 内科学第9版2007
- Author(s)
  河野修興
- Publisher
  朝倉書店,東京
- Data Source
  KAKENHI-PROJECT-19390224
[Book] 呼吸器疾患のバイオマーカー. 内科学第9版(杉本恒明・矢崎義雄総編集)2007
- Author(s)
  河野修興
- Publisher
  朝倉書店
- Data Source
  KAKENHI-PROJECT-19390224
[Book] 呼吸器疾患最新の治療2004-20062005
- Author(s)
  河野修興
- Total Pages
  458
- Publisher
  急性間質性肺炎
- Data Source
  KAKENHI-PROJECT-14370197
[Journal Article] Comparative Study of Circulating MMP-7, CCL18, KL-6, SP-A, and SP-D as Disease Markers of Idiopathic Pulmonary Fibrosis2016
- Author(s)
  Kosuke Hamai, Hiroshi Iwamoto*, Nobuhisa Ishikawa, Yasushi Horimasu, Takeshi Masuda, Shintaro Miyamoto, Taku Nakashima, Shinichiro Ohshimo, Kaznounori Fujitaka, Hironobu Hamada , Noboru Hattori, Nobuoki Kohno
- Journal Title
  
  Disease markers
  
  Volume: in press
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25253057
[Journal Article] Long-term pulmonary complications of chemical weapons exposure in former poison gas factory workers.2016
- Author(s)
  Nishimura Y, Iwamoto H, Ishikawa N, Hattori N, Horimasu Y, Ohshimo S, Kohno N.
- Journal Title
  
  Inhal Toxicol
  
  Volume: 28 Issue: 8 Pages: 1-6
- DOI
  10.3109/08958378.2016.1173133
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25253057, KAKENHI-PROJECT-16K09541
[Journal Article] MUC5B promoter polymorphism in Japanese patients with idiopathic pulmonary fibrosis.2015
- Author(s)
  Horimasu Y, Ohshimo S, Bonella F, Tanaka S, Ishikawa N, Hattori N, Kohno N, Guzman J, Costabel U.
- Journal Title
  
  Respirology.
  
  Volume: 20 Issue: 3 Pages: 439-44
- DOI
  10.1111/resp.12466
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25253057, KAKENHI-PROJECT-25860646
[Journal Article] MT95-4, a fully humanized antibody raised against aminopeptidase N, reduces tumor progression in a mouse model.2015
- Author(s)
  Akita S, Hattori N, Masuda T, Horimasu Y, Nakashima T, Iwamoto H, Fujitaka K, Miyake M, Kohno N
- Journal Title
  
  Cancer science
  
  Volume: 106 Issue: 7 Pages: 921-928
- DOI
  10.1111/cas.12692
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K21190, KAKENHI-PROJECT-25253057, KAKENHI-PROJECT-15H04831, KAKENHI-PROJECT-25860645
[Journal Article] Effect of increasing respiratory rate on airway resistance and reactance in COPD patients.2015
- Author(s)
  Nakagawa M, Hattori N, Haruta Y, Sugiyama A, Iwamoto H, Ishikawa N, Fujitaka K, Murai H, Tanaka J, Kohno N.
- Journal Title
  
  Respirology
  
  Volume: 20 Issue: 1 Pages: 87-94
- DOI
  10.1111/resp.12387
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25253057
[Journal Article] A pilot study: a combined therapy using polymyxin-B hemoperfusion and extracorporeal membrane oxygenation for acute exacerbation of interstitial pneumonia.2015
- Author(s)
  Itai J, Ohshimo S, Kida Y, Ota K, Iwasaki Y, Hirohashi N, Bonella F, Guzman J, Costabel U, Kohno N, Tanigawa K.
- Journal Title
  
  Sarcoidosis Vasc Diffuse Lung Dis
  
  Volume: 31 Pages: 343-349
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25253057
[Journal Article] Histological Quantification of Gene Silencing by Intratracheal Administration of Dry Powdered Small-Interfering RNA/Chitosan Complexes in the Murine Lung.2015
- Author(s)
  Ihara D, Hattori N, Horimasu Y, Masuda T, Nakashima T, Senoo T, Iwamoto H, Fujitaka K, Okamoto H, Kohno N
- Journal Title
  
  Pharmaceutical research
  
  Volume: 32 Issue: 12 Pages: 3877-3885
- DOI
  10.1007/s11095-015-1747-6
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K21190, KAKENHI-PROJECT-25253057, KAKENHI-PROJECT-15H04831
[Journal Article] Airway inflammation in Japanese COPD patients compared with smoking and nonsmoking controls.2015
- Author(s)
  Nobuhisa Ishikawa,1 Noboru Hattori,2 Nobuoki Kohno, Akihiro Kobayashi, Tomoyuki Hayamizu, Malcolm Johnson
- Journal Title
  
  Int J Chron Obstruct Pulmon Dis.
  
  Volume: 10 Pages: 185-92
- DOI
  10.2147/copd.s74557
- NAID
  120006799350
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25253057
[Journal Article] Differences in serum SP-D levels between German and Japanese subjects are associated with SFTPD gene polymorphisms.2014
- Author(s)
  Horimasu Y, Hattori N, Ishikawa N, Tanaka S, Bonella F, Ohshimo S, Guzman J, Costabel U, Kohno N
- Journal Title
  
  BMC Med Genet
  
  Volume: 15 Issue: 1 Pages: 4-4
- DOI
  10.1186/1471-2350-15-4
- NAID
  120006799353
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23591148, KAKENHI-PROJECT-23659433, KAKENHI-PROJECT-25253057, KAKENHI-PROJECT-25860646
[Journal Article] Baseline KL-6 predicts increased risk for acute exacerbation of idiopathic pulmonary fibrosis2014
- Author(s)
  Ohshimo S, Ishikawa N, Horimasu Y, Hattori N, Hirohashi N, Tanigawa K, Kohno N, Bonella F, Guzman J, Costabel U
- Journal Title
  
  Respir Med.
  
  Volume: 108 Issue: 7 Pages: 1031-9
- DOI
  10.1016/j.rmed.2014.04.009
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25253057, KAKENHI-PROJECT-25860646
[Journal Article] RASEF is a novel diagnostic biomarker and a therapeutic target for lung cancer.2013
- Author(s)
  Oshita H, Nishino R, Takano A, Fujitomo T, Aragaki M, Kato T, Akiyama H, Tsuchiya E, Kohno N, Nakamura Y, Daigo Y.
- Journal Title
  
  Mol Cancer Res
  
  Volume: 11 Issue: 8 Pages: 937-951
- DOI
  10.1158/1541-7786.mcr-12-0685-t
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23650624, KAKENHI-PROJECT-23659433, KAKENHI-PROJECT-24390145, KAKENHI-PROJECT-25253057, KAKENHI-PROJECT-221S0001
[Journal Article] A nationwide epidemiological survey of chronic hypersensitivity pneumonitis in Japan.2013
- Author(s)
  Okamoto T, Miyazaki Y, Ogura T, Chida K, Kohno N, Kohno S, Taniguchi H, Akagawa S, Mochizuki Y, Yamauchi K, Takahashi H, Johkoh T, Homma S, Kishi K, Ikushima S, Konno S, Mishima M, Ohta K, Nishioka Y, Yoshimura N, Munakata M, Watanabe K, Miyashita Y, Inase N.
- Journal Title
  
  Respir Investig
  
  Volume: 51 Pages: 191-199
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25253057
[Journal Article] SK-216, an inhibitor of plasminogen activator inhibitor-1, limits tumor　progression and angiogenesis.2013
- Author(s)
  Masuda T, Hattori N, Senoo T, Akita S, Ishikawa N, Fujitaka K, Haruta Y, Murai H,　Kohno N.
- Journal Title
  
  Mol Cancer Ther
  
  Volume: 12 Issue: 11 Pages: 2378-88
- DOI
  10.1158/1535-7163.mct-13-0041
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591148, KAKENHI-PROJECT-23659433, KAKENHI-PROJECT-25253057
[Journal Article] Characteristics of inspiratory and expiratory reactance in interstitial lung disease.2013
- Author(s)
  Sugiyama A, Hattori N, Haruta Y, Nakamura I, Nakagawa M, Miyamoto S, Onari Y, Iwamoto H, Ishikawa N, Fujitaka K, Murai H, Kohno N.
- Journal Title
  
  Respir Med
  
  Volume: 107 Issue: 6 Pages: 875-82
- DOI
  10.1016/j.rmed.2013.03.005
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591148, KAKENHI-PROJECT-23659433, KAKENHI-PROJECT-25253057
[Journal Article] Cross-sectional and prospective study of the association between lung function and prediabetes2013
- Author(s)
  Yamane T, Yokoyama A, Kitahara Y*, Miyamoto S, Haruta Y, Hattori N, Yamane K, Hara H, Kohno N
- Journal Title
  
  BMJ Open
  
  Volume: 3 Issue: 2 Pages: 3-3
- DOI
  10.1136/bmjopen-2012-002179
- NAID
  120006799354
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390222, KAKENHI-PROJECT-23659433, KAKENHI-PROJECT-24659405, KAKENHI-PROJECT-25253057
[Journal Article] A nationwide epidemiological survey of chronic hypersensitivity pneumonitis in Japan.2013
- Author(s)
  Okamoto T, Miyazaki Y, Ogura T, Chida K, Kohno N, Kohno S, Taniguchi H, Akagawa S, Mochizuki Y, Yamauchi K, Takahashi H, Johkoh T, Homma S, Kishi K, Ikushima S, Konno S, Mishima M, Ohta K, Nishioka Y, Yoshimura N, Munakata M, Watanabe K, Miyashita Y, Inase N.
- Journal Title
  
  Respir Investig
  
  Volume: 51 Pages: 191-199
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659433
[Journal Article] SK-216, an inhibitor of plasminogen activator inhibitor-1, limits tumor progression and angiogenesis2013
- Author(s)
  Masuda T, Hattori N, Senoo T, Akita S, Ishikawa N, Fujitaka K, Haruta Y, Murai H, Kohno N
- Journal Title
  
  Mol Cancer Ther
  
  Volume: 12 Pages: 2378-88
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659433
[Journal Article] Different MUC1 gene polymorphisms in German and Japanese ethnicities affect serum KL-6 levels2012
- Author(s)
  Horimasu Y, Hattori N, Ishikawa N, K awase S, Tanaka S, Yoshioka K, Yokoy ama A, Kohno N, Bonella F, Guzman J, Ohshimo S, Costabel U
- Journal Title
  
  Respir Med
  
  Volume: 106 Issue: 12 Pages: 1756-64
- DOI
  10.1016/j.rmed.2012.09.001
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390222, KAKENHI-PROJECT-23659433, KAKENHI-PROJECT-24659405
[Journal Article] Krebs von den Lungen-6 (KL-6) is a prognostic biomarker in patients with surgically resected non-small cell lung cancer.2012
- Author(s)
  Tanaka S, et al.
- Journal Title
  
  International journal of cancer
  
  Volume: 130 Issue: 2 Pages: 377-387
- DOI
  10.1002/ijc.26007
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390165, KAKENHI-PROJECT-23591148, KAKENHI-PROJECT-23659433
[Journal Article] Interferon (alpha, beta and omega) receptor 2 is a prognostic biomarker for lung cancer2012
- Author(s)
  Tanaka S, Hattori N, Ishikawa N, Horimasu Y, Deguchi N, Takano A, Tomoda Y, Yoshioka K, Fujitaka K, Arihiro K, Okada M, Yokoyama A, Kohno N
- Journal Title
  
  Pathobiology
  
  Volume: 79 Issue: 1 Pages: 24-33
- DOI
  10.1159/000331230
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659433
[Journal Article] Utility of KL-6/MUC1 in the clinical management of interstitial lung diseases2012
- Author(s)
  Ishikawa N, Hattori N, Yokoyama A, Kohno N
- Journal Title
  
  Respir Investig
  
  Volume: 50 Issue: 1 Pages: 3-13
- DOI
  10.1016/j.resinv.2012.02.001
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390222, KAKENHI-PROJECT-23659433, KAKENHI-PROJECT-24659405
[Journal Article] KL-6 concentration in pulmonary epithelial lining fluid is a useful prognostic indicator in patients with acute respiratory distress syndrome.2011
- Author(s)
  Kondo T, Hattori N, Ishikawa N, Murai H, Haruta Y, Hirohashi N, Tanigawa K, Kohno N.
- Journal Title
  
  Respir Res
  
  Volume: 12 Issue: 1 Pages: 32-32
- DOI
  10.1186/1465-9921-12-32
- NAID
  120003692470
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591148, KAKENHI-PROJECT-23659433
[Journal Article] Mucins carrying selectin ligands as predictive biomarkers of disseminated intravascular coagulation complication in acute respiratory distress syndrome.2011
- Author(s)
  Nakashima T, Yokoyama A, Inata J, Ishikawa N, Haruta Y, Hattori N, Kohno N.
- Journal Title
  
  Chest 139(2)
  
  Pages: 296-304
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590924
[Journal Article] Change in serum KL-6 level from baseline is useful for predicting life-threatening EGFR-TKIs induced interstitial lung disease2011
- Author(s)
  Kawase S, et al
- Journal Title
  
  Respir Res
  
  Volume: 12 Issue: 1 Pages: 97-97
- DOI
  10.1186/1465-9921-12-97
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390222, KAKENHI-PROJECT-23591148, KAKENHI-PROJECT-23659433
[Journal Article] Levels of Surfactant proteins A and D, and KL-6 are elevated in the induced sputum of COPD ; a sequential sputum analysis2011
- Author(s)
  Ishikawa N, et al
- Journal Title
  
  Respiration
  
  Volume: 82 Issue: 1 Pages: 10-18
- DOI
  10.1159/000324539
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390165, KAKENHI-PROJECT-23390222, KAKENHI-PROJECT-23591148, KAKENHI-PROJECT-23659433, KAKENHI-PROJECT-24659405
[Journal Article] KL-6 Concentration in Pulmonary Epithelial Lining Fluid and Is a Useful Prognostic Indicator in Patients with Acute Respiratory Distress Syndrome.2011
- Author(s)
  Kondo T, Hattori N, Ishikawa N, Murai H, Haruta Y, Hirohashi N, Tanigawa K, Kohno N.
- Journal Title
  
  Respiratory Research 12(1)
  
  Pages: 32-32
- NAID
  120003692470
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590924
[Journal Article] Krebs von den Lungen-6 (KL-6) is a Prognostic Biomarker for Non-SmallCell Lung Cancer2011
- Author(s)
  Tanaka S, Hattori N, Ishikawa N, Takano A, Nishino R, Shoda H, Yoshioka K, Akita S, Miyata Y, Okada M, Arihiro K, Inai K, Yokoyama A, Kohno N.
- Journal Title
  
  Int J Cancer
  
  Volume: (In press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590924
[Journal Article] Surfactant protein A and KL-6 are elevated in the induced sputum of COPD ; a sequential sputum analysis2011
- Author(s)
  Ishikawa N, Hattori N, Tanaka S, Horimasu Y, Haruta Y, Yokoyama A, Kohno N, Kinnula VL.
- Journal Title
  
  Respiration
  
  Volume: (In press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590924
[Journal Article] Erlotinib efficacy and cerebrospinal fluid concentration in lung adenocarcinoma patients developing leptomeningeal metastases during gefitinib therapy2011
- Author(s)
  Masuda T, Hattori N, Hamada A, Iwamoto H, Ohshimo S, Kanehara M, Ishikawa N, Fujitaka K, Haruta Y, Murai H, Kohno N
- Journal Title
  
  Cancer Chemoth Pharm
  
  Volume: (In press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590924
[Journal Article] Comparison of serum KL-6 versus bronchoalveolar lavage　neutrophilia for the diagnosis of bronchiolitis obliterans in lung　transplantation.2011
- Author(s)
  Ohshimo S, Bonella F, Sommerwerck U, Teschler H, Kamler M, Jakob HG, Kohno N, Guzman J, Costabel U.
- Journal Title
  
  J Heart Lung Transplant
  
  Volume: 30 Issue: 12 Pages: 1374-1380
- DOI
  10.1016/j.healun.2011.07.010
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659433
[Journal Article] KL-6 Concentration in Pulmonary Epithelial Lining Fluid and Is a Useful Prognostic Indicator in Patients with Acute Respiratory Distress Syndrome.2011
- Author(s)
  Kondo T, Hattori N, Ishikawa N, Murai H, Haruta Y, Hirohashi N, Tanigawa K, Kohno N.
- Journal Title
  
  Respiratory Research
  
  Volume: 12(電子媒体)
- NAID
  120003692470
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590924
[Journal Article] Ageing and long-term smoking affects KL-6 levels in the lung, induced sputum and plasma.2011
- Author(s)
  Ishikawa N, Mazur W, Toljamo T, Vuopala K, Rönty M, Horimasu Y, Kohno N, Kinnula VL.
- Journal Title
  
  BMC Pulm Med
  
  Volume: 11 Issue: 1 Pages: 22-22
- DOI
  10.1186/1471-2466-11-22
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591148, KAKENHI-PROJECT-23659433
[Journal Article] Ageing and long-term smoking affects KL-6 levels in the lung, induced sputum and plasma.2011
- Author(s)
  Ishikawa N, Mazur W, Toljamo T, Vuopala K, Ronty M, Horimasu Y, Kohno N, Kinnula VL.
- Journal Title
  
  BMC Pulm Med 11(1)
  
  Pages: 22-22
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590924
[Journal Article] Mucins carrying selectin ligands as predictive biomarkers of disseminated intravascular coagulation complication in acute respiratory distress syndrome2011
- Author(s)
  Nakashima T, Yokoyama A, Inata J, Ishikawa N, Haruta Y, Hattori N, Kohno N
- Journal Title
  
  Chest
  
  Volume: 139 Pages: 296-304
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590924
[Journal Article] Mucins carrying selectin ligands as predictive biomarkers of disseminated intravascular coagulation complication in ARDS2011
- Author(s)
  Nakashima T, et al
- Journal Title
  
  Chest
  
  Volume: 139 Issue: 2 Pages: 296-304
- DOI
  10.1378/chest.09-3082
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390165, KAKENHI-PROJECT-23390222, KAKENHI-PROJECT-23591148, KAKENHI-PROJECT-23659433
[Journal Article] Suppression of plasminogen activator inhibitor-1 by RNA interference attenuates pulmonary fibrosis.2010
- Author(s)
  Senoo T, Hattori N, Tanimoto T, Furonaka M, Ishikawa N, Fujitaka K, Haruta Y, Murai H, Yokoyama A, Kohno N
- Journal Title
  
  Thorax 2010 65
  
  Pages: 334-340
- NAID
  120002398984
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390224
[Journal Article] 間質性肺炎と肺癌2010
- Author(s)
  石川暢久, 河野修興
- Journal Title
  
  癌と化学療法 37
  
  Pages: 6-9
- NAID
  10025609136
- Data Source
  KAKENHI-PROJECT-20590924
[Journal Article] 間質性肺炎と肺癌2010
- Author(s)
  石川暢久, 河野修興
- Journal Title
  
  癌と化学療法
  
  Volume: 37 Pages: 6-9
- NAID
  10025609136
- Data Source
  KAKENHI-PROJECT-20590924
[Journal Article] Non-coding regionにおける遺伝子制御の最近の知見VNTR(variable number of tandem repeats)遺伝子多型による癌の進行度診断2010
- Author(s)
  石川暢久, 河野修興
- Journal Title
  
  Surgery Frontier
  
  Volume: 17 Pages: 56-58
- Data Source
  KAKENHI-PROJECT-20590924
[Journal Article] Suppression of plasminogen activator inhibitor-1 by RNA interference at tenuates pulmonary fibrosis2010
- Author(s)
  Senoo T, Hattori N, Tanimoto T, Furonaka M, Ishikawa N, Fujitaka K, Haruta Y, Murai H, Yokoyama Y, Kohno N
- Journal Title
  
  Thorax
  
  Volume: 65 Pages: 334-40
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590924
[Journal Article] Suppression of plasminogen activator inhibitor-1 by RNA interference attenuates pulmonary fibrosis.2010
- Author(s)
  Senoo T, Hattori N, Tanimoto T, Furonaka M, Ishikawa N, Fujitaka K, Haruta Y, Murai H, Yokoyama Y, Kohno N.
- Journal Title
  
  Thorax 65
  
  Pages: 334-340
- NAID
  120002398984
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590924
[Journal Article] Non-coding regionにおける遺伝子制御の最近の知見VNTR(variable number of tandem repeats)遺伝子多型による癌の進行度診断2010
- Author(s)
  石川暢久, 河野修興
- Journal Title
  
  Surgery Frontier 17
  
  Pages: 56-58
- Data Source
  KAKENHI-PROJECT-20590924
[Journal Article] Suppression of plasminogen activator inhibitor-1 by RNA interference attenuates pulmonary fibrosis.2010
- Author(s)
  Senoo T, Hattori N, Tanimoto T, Furonaka M, Ishikawa N, Fuji taka K, Haruta. Y, Murai H, Yokoyama A, Kohno N
- Journal Title
  
  Thorax 65
  
  Pages: 334-40
- NAID
  120002398984
- Data Source
  KAKENHI-PROJECT-19590898
[Journal Article] IL-12p40 is essential for the down-regulation of airway hyperresponsiveness in a mouse model of bronchial asthma with prolonged antigen exposure2009
- Author(s)
  Onari Y, Yokoyama A, Haruta Y, Nakashima T, Iwamoto H, Hattori N, Kohno N
- Journal Title
  
  Clin Exp Allergy 39
  
  Pages: 290-298
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590899
[Journal Article] Lymphocyte transformation test is not helpful for the diagnosis of methotrexate-induced pneumonitis in patients with rheumatoid arthritis.2009
- Author(s)
  Hirata S, Hattori N, Kumagai K, Haruta Y, Yokoyama A, Kohno N
- Journal Title
  
  Clin Chim Acta 2009 407
  
  Pages: 25-29
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390224
[Journal Article] Significance of bronchoalveolar lavage for the diagnosis of idiopathic pulmonary fibrosis.2009
- Author(s)
  Ohshimo S, Bonella F, Cui A, Beume M, Kohno N, Guzman J, Costabel U
- Journal Title
  
  Am J Respir Crit Care Med 2009 179
  
  Pages: 1043-1047
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390224
[Journal Article] Airflow limitation in smokers is associated with subclinical atherosclerosis2009
- Author(s)
  Iwamoto H, Yokoyama A, Kitahara Y, Ishikawa N, Haruta Y, Yamane K, Hattori N, Hara H, Kohno N
- Journal Title
  
  Am J Respir Crit Care Med 179
  
  Pages: 35-40
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590899
[Journal Article] Airflow limitation in smokers is associated with subclinical atherosclerosis.2009
- Author(s)
  Iwamoto H, Yokoyama A, Kitahara Y, Ishikawa N, Haruta Y, Yamane K, Hattori N, Hara H, Kohno N
- Journal Title
  
  Am J Respir Crit Care Med 2009 179
  
  Pages: 35-40
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390224
[Journal Article] シアル化糖鎖抗原KL-62009
- Author(s)
  石川暢久, 河野修興
- Journal Title
  
  広範囲血液・尿化学検査免疫学的検査(第7版)
  
  Pages: 358-360
- Data Source
  KAKENHI-PROJECT-20590924
[Journal Article] Genetic ablation of the Bach1 gene reduces hyperoxic lung injury in mice: role of IL-6.2009
- Author(s)
  animoto T, Hattori N, Senoo T, Furonaka M, Ishikawa N, Fujitaka K, Haruta Y, Yokoyama A, Igarashi K, Kohno N
- Journal Title
  
  Free Radic Biol Med 2009 46
  
  Pages: 1119-1126
- NAID
  120001700407
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390224
[Journal Article] シアル化糖鎖抗原KL-62009
- Author(s)
  石川暢久, 河野修興.
- Journal Title
  
  広範囲血液・尿化学検査, 免疫学的検査 (第7版) 1-その数値をどう読むか-
  
  Pages: 358-360
- Data Source
  KAKENHI-PROJECT-20590924
[Journal Article] Serum KL-6 as a novel disease marker in adolescent and adult cystic fibrosis.2009
- Author(s)
  Ohshimo S, Bonella F, Grammann N, Starke K, Cui A, Bauer PC, Teschler H, Kohno N, Guzman J, Costabel U
- Journal Title
  
  Sarcoidosis Vasc Diffuse Lung Dis 2009 26
  
  Pages: 47-53
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390224
[Journal Article] 間質性肺炎のマーカーKL-6,SP-A,SP-D2009
- Author(s)
  石川暢久, 河野修興
- Journal Title
  
  診断と治療 97
  
  Pages: 1773-1777
- Data Source
  KAKENHI-PROJECT-20590924
[Journal Article] Suplatast tosilate prevents bleomycin-induced pulmonary fibrosis in mice.2009
- Author(s)
  Furonaka M, Hattori N, Tanimoto T, Senoo T, Ishikawa N, Fujitaka K, Haruta Y, Yokoyama A, Kohno N
- Journal Title
  
  J Pharmacol Exp Ther 2009 328
  
  Pages: 55-61
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390224
[Journal Article] Perceived stress, severity of asthma and quality of life in young adults with asthma2009
- Author(s)
  Kimura T, Yokoyama A, Kohno N, Nakamura H, Eboshida A.
- Journal Title
  
  Allergol Int 58
  
  Pages: 71-79
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590899
[Journal Article] 間質性肺炎のマーカー : KL-6, SP-A, SP-D2009
- Author(s)
  石川暢久, 河野修興
- Journal Title
  
  診断と治療 97
  
  Pages: 1773-1777
- Data Source
  KAKENHI-PROJECT-20590924
[Journal Article] Suplatast tosilate prevents bleomycin-induced pulmonary fibrosis in mice2009
- Author(s)
  Furonaka M, Hattori N, Tanimoto T, Senoo T, Ishikawa N, Fujitaka K, Haruta Y, Yokoyama A, Kohno N
- Journal Title
  
  J Pharmacol Exp Ther 328
  
  Pages: 55-61
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590899
[Journal Article] IL-12p40 is essential for the down-regulation of airway hyperresponsiveness in a mouse model of bronchial asthma with prolonged antigen exposure.2009
- Author(s)
  Onari Y, Yokoyama A, Haruta Y, Nakashima T, Iwamoto H, Hattori N, Kohno N
- Journal Title
  
  Clin Exp Allergy 2009 39
  
  Pages: 290-298
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390224
[Journal Article] 腫瘍マーカーは肺がん診療に,どのように使われますか?2008
- Author(s)
  石川暢久, 河野修興
- Journal Title
  
  ナーシングケアQ&A 19
  
  Pages: 72-73
- Data Source
  KAKENHI-PROJECT-20590924
[Journal Article] 間質性肺炎のマーカーKL-62008
- Author(s)
  石川暢久, 河野修興
- Journal Title
  
  日本胸部臨床 67
- Data Source
  KAKENHI-PROJECT-20590924
[Journal Article] Usefulness of monitoring the circulating Krebs von den Lungen-6 levels to predict the clinical outcome of patients with advanced nonsmall cell lung cancer treated with epidermal growth factor receptor tyrosine kinase inhibitors.2008
- Author(s)
  Ishikawa N, Hattori N, Yokoyama A, Tanaka S, Nishino R, Yoshioka K, Ohshimo S, Fujitaka K, Ohnishi H, Hamada H, Arihiro K, Kohno N
- Journal Title
  
  nt J Cancer 2008 122
  
  Pages: 2612-2620
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390224
[Journal Article] Suppressor of cytokine signaling 1 inhibits pulmonary inflammation and fibrosis2008
- Author(s)
  Nakashima T, Yokoyama A, Onari Y, Shoda H, Haruta Y, Hattori N, Naka T, Kohno N
- Journal Title
  
  J Allergy Clin Immunol 2008 121
  
  Pages: 1269-1276
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390224
[Journal Article] 腫瘍マーカーのバイオマーカーとしての臨床的意義2008
- Author(s)
  石川暢久, 河野修興
- Journal Title
  
  医学のあゆみ「肺癌UPDATE」 224
  
  Pages: 1159-1163
- Data Source
  KAKENHI-PROJECT-20590924
[Journal Article] 間質性肺炎のマーカー・KL-62008
- Author(s)
  石川暢久, 河野修興
- Journal Title
  
  呼吸器疾患の臨床検査up to date 67
- Data Source
  KAKENHI-PROJECT-20590924
[Journal Article] Suppressor of cytokine signaling 1 inhibits pulmonary inflammation and fibrosis2008
- Author(s)
  Nakashima T, Yokoyama A, Onari Y, Shoda H, Haruta Y, Hattori N, Naka T, Kohno N
- Journal Title
  
  J Allergy Clin Immunol 121
  
  Pages: 1269-1276
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590899
[Journal Article] Usefulness of monitoring the circulating Krebs von den Lungen-6 levels to predict the clinical outcome of patients with advanced nonsmall cell lung cancer treated with epidermal growth factor receptor tyrosine kinase inhibitors.2008
- Author(s)
  Ishikawa N, Hattori N, Yokoyama A, Tanaka S, Nishino R, Yoshioka K, Ohshimo S, Fujitaka K, Ohnishi H, Hamada H, Arihiro K, Kohno N.
- Journal Title
  
  Int J Cancer 122
  
  Pages: 2612-2620
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590924
[Journal Article] Circulating KL-6/MUC1 as an independent predictor for disseminated intravascular coagulation in acute respiratory distress syndrome.2008
- Author(s)
  Nakashima T, Yokoyama A, Ohnishi H, Hamada H, Ishikawa N, Haruta Y, Hattori N, Tanigawa K, Kohno N
- Journal Title
  
  J Intern Med 2008 263
  
  Pages: 432-439
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390224
[Journal Article] 腫瘍マーカーのバイオマーカーとしての臨床的意義2008
- Author(s)
  石川暢久, 河野修興
- Journal Title
  
  医学のあゆみ 224
  
  Pages: 1159-1163
- Data Source
  KAKENHI-PROJECT-20590924
[Journal Article] Circulating KL-6/MUC1 as an independent predictor for disseminated intravascular coagulation in acute respiratory distress syndrome.2008
- Author(s)
  Nakashima T, Yokoyama A, Ohnishi H, Hamada H, Ishikawa N, Haruta Y, Hattori N, Tanigawa K, Kohno N.
- Journal Title
  
  J Intern Med 263
  
  Pages: 432-439
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590924
[Journal Article] Usefulness of monitoring the circulating Krebs von den Lungen-6 levels to predict the clinical outcome of patients with advanced nonsmall cell lung cancer treated with epidermal growth factor receptor tyrosine kinase inhibitors2008
- Author(s)
  Ishikawa N, Hattori N, Yokoyama A, Tanaka S, Nishino R, Yoshioka K, Ohshimo S, Fujitaka K, Ohnishi H, Hamada H, Arihiro K, Kohno N
- Journal Title
  
  Int J Cancer 122
  
  Pages: 2612-2620
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590899
[Journal Article] Circulating KL-6/MUC1 as an independent predictor for disseminated intravascular coagulation in acute respiratory distress syndrome2008
- Author(s)
  Nakashima T, Yokoyama A, Ohnishi H, Hamada H, Ishikawa N, Haruta Y, Hattori N, Tanigawa K, Kohno N
- Journal Title
  
  J Intern Med 263
  
  Pages: 432-439
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590899
[Journal Article] Anti-inflammatory effects and clinical efficacy of theophylline and tulobuterol in mild-to-moderate chronic obstructive pulmonary disease.2008
- Author(s)
  Kanehara M, Yokoyama A, Tomoda Y, Shiota N, Iwamoto H, Ishikawa N, Taooka Y, Haruta Y, Hattori N, Kohno N
- Journal Title
  
  Pulm Pharmacol Ther 2008 21
  
  Pages: 874-878
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390224
[Journal Article] Anti-inflammatory effects and clinical efficacy of theophylline and tulobuterol in mild-to-moderate chronic obstructive pulmonary disease2008
- Author(s)
  Kanehara M, Yokoyama A, Tomoda Y, Shiota N, Iwamoto H, Ishikawa N, Taooka Y, Haruta Y, Hattori N, Kohno N
- Journal Title
  
  Pulm Pharmacol Ther 21
  
  Pages: 874-878
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590899
[Journal Article] 薬剤性肺障害2008
- Author(s)
  石川暢久, 河野修興
- Journal Title
  
  リウマチ科 40
  
  Pages: 363-370
- Data Source
  KAKENHI-PROJECT-20590924
[Journal Article] Differential expression of the glycosylated forms of MUC1 during lung development.2007
- Author(s)
  Sakurai J, Hattori N, Nakajima M, Moriya T, Suzuki T, Yokoyama A, Kohno N
- Journal Title
  
  Eur J Histochem 2007 51
  
  Pages: 95-102
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390224
[Journal Article] Immunohistochemical and immunoelectron microscopic studies of the localization of KL-6 and epithelial membrane antigen (EMA) in presumably normal pulmonary tissue and in interstitial pneumonia2007
- Author(s)
  Ohtsuki Y, Fujita J, Hachisuka Y, Uomoto M, Okada Y, Yoshinouchi T, Lee GH, Furihata M, Kohno N
- Journal Title
  
  Med Mol Morphol 40
  
  Pages: 198-202
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590899
[Journal Article] Circulating KL-6/MUC1 mucin carrying sialyl Lewisa oligcsaccharide is an independent prognostic factor in patients with lung adenocarcinoma2007
- Author(s)
  Inata J, Hattori N, Yokoyama A, Ohshimo S, Doi M, Ishikawa N, Hamada H, Kohno N
- Journal Title
  
  Int J Cancer 120
  
  Pages: 2643-2649
- Data Source
  KAKENHI-PROJECT-19590898
[Journal Article] Immunohistochemical and immunoelectron microscopic studies of the localization of KL-6 and epithelial membrane antigen (EMA) in presumably normal pulmonary tissue and in interstitial pneumonia.2007
- Author(s)
  Ohtsuki Y, Fujita J, Hachisuka Y, Uomoto M, Okada Y, Yoshinouchi T, Lee GH, Furihata M, Kohno N
- Journal Title
  
  Med Mol Morphol 2007 40
  
  Pages: 198-202
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390224
[Journal Article] Differential expression of the glycosylated forms of MUC1 during lung development2007
- Author(s)
  Sakurai J, Hattori N, Nakajima M, Moriya T, Suzuki T, Yokoyama A, Kohno N
- Journal Title
  
  Eur J Histochem 51
  
  Pages: 95-102
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590899
[Journal Article] Overproduction of collagen and diminished SOCS1 expression are causally linked in fibroblasts from idiopathic pulmonary fibrosis2007
- Author(s)
  Shoda H, Yokoyama A, Nishino R, Nakashima T, Ishikawa N, Haruta Y, Hattori N, Naka T, Kohno N.
- Journal Title
  
  Biochem Biophys Res Commun 353
  
  Pages: 1004-1010
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590747
[Journal Article] Cancer-testis antigen lymphocyte antigen 6 complex locus K is a serologic biomarker and a therapeutic target for lung and esophageal carcinomas2007
- Author(s)
  Ishikawa N, Takano A, Yasui W, Inai K, Nishimura H, Ito H, Miyagi Y, Nakayama H, Fujita M, Hosokawa M, Tsuchiya E, Kohno N, Nakamura Y, Daigo Y
- Journal Title
  
  Cancer Res 1567
  
  Pages: 11601-11611
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590899
[Journal Article] Activation of KIF4A as a prognostic biomarker and therapeutic target for lung cancer2007
- Author(s)
  Taniwaki M, Takano A, Ishikawa N, Yasui W, Inai K, Nishimura H, Tsuchiya E, Kohno N, Nakamura Y, Daigo Y
- Journal Title
  
  Clin Cancer Res 13(22 Pt 1)
  
  Pages: 6624-6631
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590899
[Journal Article] Prognostic Value of Circulating KL-6 in Idiopathic Pulmonary Fibrosis.2006
- Author(s)
  Yokoyama A, Kondo K, Nakajima M, Matsushima T, Takahashi T, Nishimura M, Bando M, Sugiyama Y, Totani Y, Ishizaki T, Ichiyasu H, Suga M, Hamada H, Kohno N.
- Journal Title
  
  Respirology 11
  
  Pages: 164-168
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590747
[Journal Article] Air Trapping in Patients with Asthma May Represent Remodeling of Small Airways.2006
- Author(s)
  Ito R, Yokoyama A, Hamada H, Yasuhara Y, Kohno N, Higaki J.
- Journal Title
  
  J Asthma 43
  
  Pages: 25-29
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590747
[Journal Article] Anti-tumor effect of the anti-KL-6/MUCI monoclonal antibody through exposure of surface molecules by MUC1 capping.2006
- Author(s)
  Doi M, Yokoyama A, Kondo K, Ohnishi H, Ishikawa N, Hattori N, Kohno N.
- Journal Title
  
  Cancer Sci 97
  
  Pages: 420-429
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590747
[Journal Article] KL-6, a Human MUCI Mucin, Promotes Proliferation and Survival of Lung Fibroblasts.2005
- Author(s)
  Ohshimo S, Yokoyama A, Hattori N, Ishikawa N, Hirasawa Y, Kohno N.
- Journal Title
  
  Biochem Biophys Res Comm 338
  
  Pages: 1845-1852
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590747
[Journal Article] Circulating aminopeptidase N/CD13 is an independent prognostic factor in patients with non-small cell lung cancer.2005
- Author(s)
  Murakami H, Yokoyama A, Kondo K, Nakanishi S, Kohno N, Miyake M.
- Journal Title
  
  Clin Cancer Res 11
  
  Pages: 8674-8679
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590747
[Journal Article] Adoptive Transfer of Th1 Clones Inhibits Eosinophilic Inflammation and Airway Hyperresponsiveness in a Murine Model of Asthma2005
- Author(s)
  H, Hamada H, Nakajima M, Kohno N, Higaki J.
- Journal Title
  
  Eur Respir J 25
  
  Pages: 653-659
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590747
[Journal Article] Polymorphism of MUC1 mucin gene is associated with susceptibility and prognosis of lung adenocarcinoma.2005
- Author(s)
  Mitsuta K, Yokoyama A, Kondo K, Nakajima M, Kohno N.
- Journal Title
  
  Oncol Rep 14
  
  Pages: 185-189
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590747
[Journal Article] Sialylated carbohydrate antigen KL-6.2004
- Author(s)
  Kohno N
- Journal Title
  
  Nippon Rinsho 62・S11
  
  Pages: 321-324
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370197
[Journal Article] Circulating Natural Killer T Cells in Patients with Asthma Irifune K, Yokoyama A, Sakai K, Watanabe A, Katayama H, Ohnishi2004
- Author(s)
  Ikegami Y, Yokoyama A, Haruta Y, Hiyama K, Mendoza C, Kohno K.
- Journal Title
  
  J Asthma 41
  
  Pages: 877-882
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590747
[Journal Article] シアル化糖鎖抗原KL-62004
- Author(s)
  河野修興
- Journal Title
  
  日本臨床広範囲血液・尿化学検査免疫学的検査-その数値をどう読むか- 62・S11
  
  Pages: 321-324
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14370197
[Journal Article] シアル化糖鎖抗原KL-62004
- Author(s)
  河野修興
- Journal Title
  
  日本臨床広範囲血液・尿化学検査免疫学的検査-その数値をどう読むか- 62・S11
  
  Pages: 321-324
- Data Source
  KAKENHI-PROJECT-14370197
[Journal Article] Krebs von den Lungen-6 (KL-6) is a Prognostic Biomarker for Non-Small Cell Lung Cancer.
- Author(s)
  Tanaka S, Hattori N, Ishikawa N, Shoda H, Takano A, Nishino R, Okada M, Arihiro K, Inai K, Hamada H, Yokoyama A, Kohno N.
- Journal Title
  
  Int J Cancer (印刷中)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590924
[Journal Article] Surfactant protein A and KL-6 are elevated in the induced sputum of COPD ; a sequential sputum analysis.
- Author(s)
  Ishikawa N, Hattori N, Tanaka S, Horimasu Y, Haruta Y, Yokoyama A, Kohno N, Kinnula VL.
- Journal Title
  
  Respiration (印刷中)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590924
[Journal Article] Productive cough is an independent risk factor for the development of COPD in former smokers.
- Author(s)
  Yamane T, Hattori N, Kitahara Y, Haruta Y, Sasaki H, Yokoyama A, Kohno N
- Journal Title
  
  Respirology 2010 15
  
  Pages: 313-318
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390224
[Journal Article] Overexpression of Suppressor of Cytokine Signaling-5 Augments Eosinophilic Airway Inflammation in Mice
- Author(s)
  Ohshima M, Yokoyama A, Ohnishi H, Hamada H, Kohno N, Higaki J, Naka T.
- Journal Title
  
  Clin Exp Allergy (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590747
[Journal Article] Erlotinib efficacy and cerebrospinal fluid concentration in lung adenocarcinoma patients developing leptomeningeal metastases during gefitinib therapy.
- Author(s)
  Masuda T, Hattori N, Hamada A, Iwamoto H, Ohshimo S, Kanehara M, Ishikawa N, Fujitaka K, Haruta Y, Murai H, Kohno N.
- Journal Title
  
  Cancer Chemoth Pharm (印刷中)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590924
[Patent] 癌の病態進行を予測する方法2005
- Inventor(s)
  河野修興, 満田一博他3名
- Industrial Property Rights Holder
  広島大学
- Industrial Property Number
  2005-060726
- Filing Date
  2005-03-04
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14370197
[Patent] 癌の病態進行を予測する方法2005
- Inventor(s)
  河野修興, 満田一博, 他3名
- Industrial Property Rights Holder
  広島大学
- Industrial Property Number
  2005-060726
- Filing Date
  2005-03-04
- Data Source
  KAKENHI-PROJECT-14370197
[Presentation] MUC1 gene polymorphism and serum KL-6 in lung adenocarcinoma.2015
- Author(s)
  Horimasu Y, Ishikawa N, Tanaka S, Iwamoto H, Ohshimo S, Fujitaka K, Hattori N, Hamada H, Kohno N.
- Organizer
  European Respiratory Society International Congress 2015
- Place of Presentation
  アムステルダム（オランダ）
- Year and Date
  2015-09-26
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25253057
[Presentation] 特発性肺線維症における血清バイオマーカーの意義に関する検討2015
- Author(s)
  濵井宏介、岩本博志、石川暢久、大下慎一郎、濱田泰伸、堀益靖、藤高一慶、村井博、服部登、河野修興
- Organizer
  第55回日本呼吸器学会学術講演会
- Place of Presentation
  東京国際フォーラム（東京）
- Year and Date
  2015-04-17
- Data Source
  KAKENHI-PROJECT-25253057
[Presentation] 日本人の間質性肺炎急性増悪症例における体外式膜型人工肺（ECMO）の有用性2015
- Author(s)
  大下慎一郎, 木田佳子, 太田浩平, 京道人, 島谷竜俊, 儀賀普嗣, 小山和宏, 稲川嵩紘, 鈴木慶, 山賀聡之, 田邉優子, 大谷直嗣, 貞森拓磨, 宇根一暢, 津村龍, 岩崎泰昌, 廣橋伸之, 服部登, 河野修興, 谷川攻一
- Organizer
  第37回日本呼吸療法医学会総会
- Place of Presentation
  国立京都国際会館館（京都）
- Year and Date
  2015-07-17
- Data Source
  KAKENHI-PROJECT-25253057
[Presentation] Comparative analysis of multiple gene polymorphisms for acute exacerbation of idiopathic pulmonary fibrosis.2015
- Author(s)
  Ohshimo S, Yamaoka C, Horimasu Y, Iwamoto H, Fujitaka K, Hamada H, Hattori N, Hirohashi N, Tanigawa K, Bonella F, Guzman J, Costabel U, Kohno N.
- Organizer
  European Respiratory Society International Congress 2015
- Place of Presentation
  アムステルダム（オランダ）
- Year and Date
  2015-09-26
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25253057
[Presentation] HRCT Findings as a Predictive Factor for Acute Exacerbation of Idiopathic Pulmonary Fibrosis.2015
- Author(s)
  Yamaoka C, Horimasu Y, Iwamoto H, Ohshimo S, Fujitaka K, Murai H, Hattori N, Hamada H, Kohno N.
- Organizer
  第55回日本呼吸器学会学術講演会
- Place of Presentation
  東京国際フォーラム（東京）
- Year and Date
  2015-04-17
- Data Source
  KAKENHI-PROJECT-25253057
[Presentation] Growth differentiation factor-15 (GDF-15) as prognostic factor in German patients with idiopathic pulmonary fibrosis.2015
- Author(s)
  Ohshimo S, Hamai K, Bonella F, Yamaoka C, Horimasu Y, Iwamoto H, Ishikawa N, Fujitaka K, Murai H, Hamada H, Hattori N, Hirohashi N, Tanigawa K, Guzman J, Costabel U, Kohno N.
- Organizer
  American Thoracic Society　International Conference 2015
- Place of Presentation
  デンバー（アメリカ合衆国）
- Year and Date
  2015-05-17
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25253057
[Presentation] Growth differentiation factor-15 (GDF-15) as prognostic factor in Caucasians with idiopathic pulmonary fibrosis.2015
- Author(s)
  Ohshimo S, Hamai K, Bonella F, Yamaoka C, Horimasu Y, Iwamoto H, Ishikawa N, Fujitaka K, Murai H, Hamada H, Hattori N, Hirohashi N, Tanigawa K, Guzman J, Costabel U, Kohno N.
- Organizer
  第55回日本呼吸器学会学術講演会
- Place of Presentation
  東京国際フォーラム（東京）
- Year and Date
  2015-04-17
- Data Source
  KAKENHI-PROJECT-25253057
[Presentation] 放射線肺線維症マウスモデルにおける肺の線維化とPAI-1(plasminogen activator inhibitor-1)の関与についての検討2015
- Author(s)
  塩谷咲千子、服部登、平野有美、妹尾直、益田武、堀益靖、中島拓、岩本博志、藤高一慶、河野修興
- Organizer
  第55回日本呼吸器学会学術講演会
- Place of Presentation
  東京国際フォーラム（東京）
- Year and Date
  2015-04-17
- Data Source
  KAKENHI-PROJECT-25253057
[Presentation] Ethnic difference in the incidence of acute exacerbation in idiopathic pulmonary fibrosis2013
- Author(s)
  Ohshimo S, Ishikawa N, Horimasu Y, Fujitaka K, Haruta Y, Murai H, Hattori N, Bonella F, Kohno N, Guzman J, Costabel U.
- Organizer
  American Thoracic society international Conference 2013
- Place of Presentation
  フィラデルフィア、アメリカ
- Data Source
  KAKENHI-PROJECT-23659433
[Presentation] Discovery and clinical application of KL-6, a circulating biomarker for interstitial lung diseases.2013
- Author(s)
  Kohno N.
- Organizer
  2013 European Respiratory Society Annual Congress
- Place of Presentation
  バルセロナ、スペイン
- Invited
- Data Source
  KAKENHI-PROJECT-23659433
[Presentation] 3. Ethnic difference in the incidence of acute exacerbation in idiopathic pulmonary fibrosis.2013
- Author(s)
  Ohshimo S, Ishikawa N, Horimasu Y, Fujitaka K, Haruta Y, Murai H, Hattori N, Bonella F, Kohno N, Guzman J, Costabel U.
- Organizer
  American Thoracic society international Conference 2013
- Place of Presentation
  フィラデルフィア、アメリカ
- Data Source
  KAKENHI-PROJECT-25253057
[Presentation] MUC1 gene polymorphisms are associated with serum KL-6 levels and pulmonary dysfunction in pulmonary alveolar proteinosis.2013
- Author(s)
  Ohshimo S, Horimasu Y, Bonella F, Ishikawa N, Fujitaka K, Haruta Y, Murai H, Hirohashi N, Hattori N, Tanigawa K, KohnoN, Guzman J, Costabel U.
- Organizer
  2013 European Respiratory Society Annual Congress
- Place of Presentation
  バルセロナ、スペイン
- Data Source
  KAKENHI-PROJECT-23659433
[Presentation] Gene expression profiles of chronic hypersensitivity pneumonitis: Molecular signatures of pulmonary fibrosis.2013
- Author(s)
  Ishikawa N, Taniwaki M, Horimasu Y, Iwamoto H, Ohshimo S, Fujitaka K, Haruta Y, Murai H, Hattori N, Kohno N.
- Organizer
  American Thoracic society international Conference 2013
- Place of Presentation
  フィラデルフィア、アメリカ
- Data Source
  KAKENHI-PROJECT-25253057
[Presentation] KL-6, SP-D and MMP-7 as serum biomarkers for early detection of interstitial lung diseases.2013
- Author(s)
  Ishikawa N, Yoshioka K, Horimasu Y, Iwamoto H, Ohshimo S, Hattori N, Kohno N.
- Organizer
  2013 European Respiratory Society Annual Congress
- Place of Presentation
  バルセロナ、スペイン
- Data Source
  KAKENHI-PROJECT-23659433
[Presentation] 4. KL-6, SP-D and MMP-7 as serum biomarkers for early detection of interstitial lung diseases.2013
- Author(s)
  Ishikawa N, Yoshioka K, Horimasu Y, Iwamoto H, Ohshimo S, Hattori N, Kohno N.
- Organizer
  2013 European Respiratory Society Annual Congress
- Place of Presentation
  バルセロナ、スペイン
- Data Source
  KAKENHI-PROJECT-25253057
[Presentation] Difference of serum SP-D levels between German and Japanese are associated with SFTP gene polymorphisms.2013
- Author(s)
  Horimasu Y, Hattori N, Ishikawa N, Tanaka S, Bonella F, Ohshimo S, Guzman J, Costabel U, KohnoN.
- Organizer
  American Thoracic society international Conference 2013
- Place of Presentation
  フィラデルフィア、アメリカ
- Data Source
  KAKENHI-PROJECT-25253057
[Presentation] Antitumor effect of a humanized antibody against aminopeptidase N in mouse tumor models2013
- Author(s)
  Akita S, Hattori N, Ishikawa N, Fujitaka K, Haruta Y, Murai H, Kohno N
- Organizer
  18th congress of the Asian Pacific Society of Respirology
- Place of Presentation
  横浜
- Year and Date
  2013-11-11
- Data Source
  KAKENHI-PROJECT-23659433
[Presentation] MUC1 gene polymorphisms are associated with serum KL-6 levels and pulmonary dysfunction in pulmonary alveolar proteinosis.2013
- Author(s)
  Ohshimo S, Horimasu Y, Bonella F, Ishikawa N, Fujitaka K, Haruta Y, Murai H, Hirohashi N, Hattori N, Tanigawa K, KohnoN, Guzman J, Costabel U.
- Organizer
  2013 European Respiratory Society Annual Congress
- Place of Presentation
  バルセロナ、スペイン
- Data Source
  KAKENHI-PROJECT-25253057
[Presentation] Difference of serum SP-D levels between German and Japanese are associated with SFTP gene polymorphisms.2013
- Author(s)
  Horimasu Y, Hattori N, Ishikawa N, Tanaka S, Bonella F, Ohshimo S, Guzman J, Costabel U, KohnoN.
- Organizer
  American Thoracic society international Conference 2013
- Place of Presentation
  フィラデルフィア、アメリカ
- Data Source
  KAKENHI-PROJECT-23659433
[Presentation] Gene expression profiles of chronic hypersensitivity pneumonitis: Molecular signatures of pulmonary fibrosis.2013
- Author(s)
  Ishikawa N, Taniwaki M, Horimasu Y, Iwamoto H, Ohshimo S, Fujitaka K, Haruta Y, Murai H, Hattori N, Kohno N.
- Organizer
  American Thoracic society international Conference 2013
- Place of Presentation
  フィラデルフィア、アメリカ
- Data Source
  KAKENHI-PROJECT-23659433
[Presentation] Discovery and clinical application of KL-6, a circulating biomarker for interstitial lung diseases2013
- Author(s)
  Kohno N
- Organizer
  2013 European Respiratory Society Annual Congress
- Place of Presentation
  Barcelona Spain
- Year and Date
  2013-09-07
- Data Source
  KAKENHI-PROJECT-23659433
[Presentation] Discovery and clinical application of KL-6, a circulating biomarker for interstitial lung diseases2013
- Author(s)
  Kohno N
- Organizer
  European Respiratory Society Annual Congress
- Place of Presentation
  バルセロナ、スペイン
- Invited
- Data Source
  KAKENHI-PROJECT-25253057
[Presentation] KL-6 is a useful serum biomarker for early detection of interstitial lung disease.2012
- Author(s)
  Kohno N, Ishikawa N, Deguchi N, Iwamoto H, Ohshimo S, Fujitaka K, Haruta Y, Murai H, Hattori N.
- Organizer
  European Respiratory Society Annual Congress
- Place of Presentation
  Vienna（オーストリア)
- Data Source
  KAKENHI-PROJECT-23659433
[Presentation] Different serum cut-off values of KL-6 for German and Japanese to diagnose iIdiopathic interstitial pneumonias are related to different Mucin-1 gene polymorphisms.2012
- Author(s)
  Horimasu Y, Hattori N, Ishikawa N, Tanaka S, Yoshioka K, Bonella F, Ohshimo S, Guzman J, Kohno N, Costabel U.
- Organizer
  American Thoracic Society International Conference
- Place of Presentation
  San Francisco（アメリカ.)
- Data Source
  KAKENHI-PROJECT-23659433
[Presentation] Gene expression profiles of idiopathic interstitial pneumonias: Identification of disease-specific diagnostic markers and molecular therapeutic targets.2012
- Author(s)
  Ishikawa N, Hattori N, Taniwaki M, Horimasu Y, Matsuda T, Kohno N.
- Organizer
  European Respiratory Society Annual Congress
- Place of Presentation
  Vienna（オーストリア）
- Data Source
  KAKENHI-PROJECT-23659433
[Presentation] KL-6 and CCL18 as predictors for acute exacerbation in idiopathic pulmonary fibrosis.2012
- Author(s)
  Ohshimo S , Horimasu Y, Bonella F, Ishikawa N, Hattori N, Tanigawa K, Kohno N, Guzman J, Costabel U.
- Organizer
  American Thoracic Society International Conference
- Place of Presentation
  San Francisco（アメリカ.)
- Data Source
  KAKENHI-PROJECT-23659433
[Presentation] Different cutoff values of serum SP-D for German and Japanese to diagnose idiopathic interstitial pneumonias are related to different SFTPD gene polymorphisms.2012
- Author(s)
  Horimasu Y, Hattori N, Ishikawa N, Tanaka S, Yoshioka K, Bonella F, Ohshimo S, Guzman J, Costabel U, Kohno N.
- Organizer
  European Respiratory Society Annual Congress
- Place of Presentation
  Vienna（オーストリア）
- Data Source
  KAKENHI-PROJECT-23659433
[Presentation] nterferon (-alpha, -beta, and -omega) receptor 2 (IFNAR2) is a prognostic biomarker for lung cancer.2011
- Author(s)
  Ishikawa N, Hattori N, Tanaka S, Horimasu Y, Yokoyama A, Kohno N.
- Organizer
  European Respiratory Society Annual Congress
- Place of Presentation
  Amsterdam, Netherlands
- Data Source
  KAKENHI-PROJECT-23659433
[Presentation] Serum KL-6 is a useful diagnostic and prognostic biomarker in idiopathic interstitial pneumonia in German patients.2011
- Author(s)
  Horimasu Y, Ohshimo S, Ishikawa N, Tanaka S, Yoshioka K, Bonella F, Hattori N, Kohno N, Guzman J, Costabel U.
- Organizer
  American Thoracic Society International Conference
- Place of Presentation
  Denver, U.S.A.
- Data Source
  KAKENHI-PROJECT-23659433
[Presentation] Serum SP-A and SP-D: different cutoff values for German and Japanese patients to diagnose idiopathic interstitial pneumonia.2011
- Author(s)
  Horimasu Y, Hattori N, Ishikawa N, Tanaka S, Yoshioka K, Ohshimo S, Bonella F, Guzman J, Costabel U, Kohno N.
- Organizer
  European Respiratory Society Annual Congress
- Place of Presentation
  Amsterdam, Netherlands
- Data Source
  KAKENHI-PROJECT-23659433
[Presentation] Krebs von den lungen-6 (KL-6) is a useful biomarker for life threatening EGFR-TKI related interstitial lung disease2011
- Author(s)
  Kawase S, Hattori N, Ishikawa N, Horimasu Y, Furonaka O, Isobe T, Hamada H, Yokoyama A, Kohno N
- Organizer
  American Thoracic Society International Conference
- Place of Presentation
  Denver, U.S.A.
- Data Source
  KAKENHI-PROJECT-23659433
[Presentation] Reliability of ATS/ERS criteria for the diagnosis of idiopathic pulmonary fibrosis.2011
- Author(s)
  Ohshimo S, Bonella F, Tanigawa K, Kohno N, Guzman J, Costabel U.
- Organizer
  European Respiratory Society Annual Congress
- Place of Presentation
  Amsterdam, Netherlands
- Data Source
  KAKENHI-PROJECT-23659433
[Presentation] Krebs von den Lungen-6 (KL-6) is a prognostic biomarker in patients with surgically resected nonsmall cell lung cancer2011
- Author(s)
  Tanaka S, Ishikawa N, Hattori N, Hamada H, Yokoyama A, Kohno N
- Organizer
  2011 European Respiratory Society Annual Congress
- Place of Presentation
  Amsterdam, Netherlands
- Year and Date
  2011-09-24
- Data Source
  KAKENHI-PROJECT-23659433
[Presentation] EGFR-TKIによる致死的薬剤性肺障害におけるKL-6値の有用性の検討2010
- Author(s)
  河瀬成穂, 服部登, 石川暢久, 高野淳, 堀益靖, 礒部威, 濱田泰伸, 横山彰仁, 河野修興
- Organizer
  第69回日本癌学会総会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-20590924
[Presentation] Krebs von den Lungen-6(KL-6) is a Serologic and Prognostic Biomarker and a Possible Therapeutic Target for IPF (International Symposium)2009
- Author(s)
  河野修興
- Organizer
  第48回日本呼吸器学会総会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-19390224
[Presentation] 外科的切除を行った非小細胞性肺癌におけるKL-6/MUC1の検討2009
- Author(s)
  田中惣之輔, 石川暢久, 吉岡宏治, 藤高一慶, 春田吉則, 村井博, 服部登, 河野修興
- Organizer
  第49回日本呼吸器学会学術講演会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-20590924
[Presentation] 間質性肺炎と肺癌2009
- Author(s)
  河野修興
- Organizer
  日本内科学会総会
- Place of Presentation
  東京・東京国際フォーラム
- Year and Date
  2009-04-10
- Data Source
  KAKENHI-PROJECT-19390224
[Presentation] 間質性肺炎と肺癌2009
- Author(s)
  河野修興
- Organizer
  日本内学会総会
- Place of Presentation
  東京都
- Data Source
  KAKENHI-PROJECT-19390224
[Presentation] 非腫瘍性呼吸器疾患におけるsialyl Lewis aを有するKL-6の検討2009
- Author(s)
  吉岡宏治, 石川暢久, 稲田順也, 田中惣之輔, 大下慎一郎, 長尾早江子, 春田吉則, 村井博, 服部登, 河野修興
- Organizer
  第49回日本呼吸器学会学術講演会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-20590924
[Presentation] Gefitinib使用患者における血清KL-6値モニタリングの意義2008
- Author(s)
  石川暢久, 服部登, 横山彰仁, 吉岡宏治, 田中惣之輔, 河瀬成穂, 藤高一慶, 濱田泰伸, 河野修興
- Organizer
  第48回日本呼吸器学会総会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-20590924
[Presentation] Krebs von den Lungen-6 (KL-6)is a Serologic and Prognostic Biomarker and a Possible Therapeutic Target for IPF (International Symposium)2008
- Author(s)
  河野修興
- Organizer
  第48回日本呼吸器学会総会
- Place of Presentation
  名古屋国際会議場・名古屋市
- Year and Date
  2008-06-17
- Data Source
  KAKENHI-PROJECT-19390224
[Presentation] KL-6の発見から臨床応用まで(シンポジウムI : 糖質科学とバイオマーカー)2008
- Author(s)
  河野修興
- Organizer
  第28回日本糖質学会年会
- Place of Presentation
  つくば国際会議場・つくば市
- Year and Date
  2008-08-18
- Data Source
  KAKENHI-PROJECT-19390224
[Presentation] KL-6の発見から臨床応用まで2008
- Author(s)
  河野修興
- Organizer
  第28回日本糖質学会年会
- Place of Presentation
  つくば
- Year and Date
  2008-08-18
- Data Source
  KAKENHI-PROJECT-19390224
[Presentation] Cancer-testis Antigen LY6K is a Serologic Biomarker and a Therapeutic Target for Lung and Esophageal Carcinomas.2008
- Author(s)
  Ishikawa N, Takano A, Miyagi Y, Yasui W, Inai K, Hosokawa M, Tsuchiya E, Kohno N, Nakamura Y, Daigo Y.
- Organizer
  第67回日本癌学会学術総会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-20590924
[Presentation] 薬物性肺障害の種類と診断の要点2007
- Author(s)
  河野修興
- Organizer
  第104回日本内科学会総会
- Place of Presentation
  大阪市
- Year and Date
  2007-04-03
- Data Source
  KAKENHI-PROJECT-19390224
[Presentation] 呼吸はメタボリック症候群克服のキーファクターである2007
- Author(s)
  河野修興
- Organizer
  第61回日本交通医学会総会
- Place of Presentation
  広島
- Year and Date
  2007-06-09
- Data Source
  KAKENHI-PROJECT-19390224
[Presentation] 血清マーカーによる薬剤性肺炎の診断2007
- Author(s)
  河野修興
- Organizer
  第49回日本内科学会東北支部主催生涯教育講演会
- Place of Presentation
  仙台
- Year and Date
  2007-06-16
- Data Source
  KAKENHI-PROJECT-19390224
[Presentation] 薬物性肺障害の種類と診断の要点2007
- Author(s)
  河野修興
- Organizer
  第104回日本内科学会総会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-19390224
[Presentation] 3.Annual decline in lung function can predict the prognosis of patients with chronic hypersensitivity pneumonia
- Author(s)
  Horimasu Y, Ishikawa N, Nakashima T, Iwamoto H, Senoo T, Ohshimo S, Fujitaka K, Haruta Y, Murai H, Hattori N, Kohno N
- Organizer
  American Thoracic society international Conference
- Place of Presentation
  San Diego, USA
- Year and Date
  2014-05-16 – 2014-05-21
- Data Source
  KAKENHI-PROJECT-25253057
[Presentation] 13.Angiopoietin-2 Gene Polymorphism as Prognostic Factor in Caucasians with Idiopathic Pulmonary Fibrosis
- Author(s)
  Ohshimo S, Horimasu Y, Bonella F, Iwamoto H, Ishikawa N, Fujitaka K, Haruta Y, Murai H, Hattori N, Hirohashi N, Tanigawa K, Guzman J, Costabel U, Kohno N
- Organizer
  European Respiratory Society Annual Congress
- Place of Presentation
  Munich, Germany
- Year and Date
  2014-09-06 – 2014-09-10
- Data Source
  KAKENHI-PROJECT-25253057
[Presentation] 1.Gene expression profiles of idiopathic interstitial pneumonias: Molecular signatures of pulmonary fibrosis
- Author(s)
  Ishikawa N, Masuda T, Horimasu Y, Hattori N, Ohshimo S, Kohno N
- Organizer
  American Thoracic society international Conference
- Place of Presentation
  San Diego, USA
- Year and Date
  2014-05-16 – 2014-05-21
- Data Source
  KAKENHI-PROJECT-25253057
[Presentation] 2.Impact of Ethnic Difference and TERT Gene Polymorphisms in the Acute Exacerbation of Idiopathic Pulmonary Fibrosis
- Author(s)
  Ohshimo S, Ishikawa N, Horimasu Y, Fujitaka K, Haruta Y, Murai H, Hattori N, Bonella F, Guzman J, Costabel U, Kohno N
- Organizer
  American Thoracic society international Conference
- Place of Presentation
  San Diego, USA
- Year and Date
  2014-05-16 – 2014-05-21
- Data Source
  KAKENHI-PROJECT-25253057
[Presentation] 1.Bronchoalveolar lavage cellular pattern can predict the prognosis of patients with chronic hypersensitivity pneumonia
- Author(s)
  Horimasu Y, Ishikawa N, Nakashima T, Senoo T, Ohshimo S, Fujitaka K, Haruta Y, Murai H, Hattori N, Kohno N
- Organizer
  第54回日本呼吸器学会学術講演会
- Place of Presentation
  大阪
- Year and Date
  2014-04-25 – 2014-04-27
- Data Source
  KAKENHI-PROJECT-25253057

1. YOKOYAMA Akihito (30191513)

# of Collaborated Projects: 12 results

# of Collaborated Products: 26 results
2. HATTORI Noboru (00283169)

# of Collaborated Projects: 6 results

# of Collaborated Products: 76 results
3. ISHIKAWA Nobuhisa (90423368)

# of Collaborated Projects: 5 results

# of Collaborated Products: 92 results
4. MIYAKE Masayuki (90250076)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
5. IWAMOTO Hiroshi (60457398)

# of Collaborated Projects: 2 results

# of Collaborated Products: 14 results
6. HIYAMA Keiko (60253069)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. KONDO Keiichi (20332827)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
8. SAKAI Mizu (40403886)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. OHNISHI Hiroshi (90553876)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. KONDOH Tomohiro (40444690)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. INOUE Yoshikazu (90240895)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. NAKA Tetsuji (30303936)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. HAMADA Hironobu (80314954)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. NAKAJIMA Masamitsu (20198097)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 田口禎一郎 (80216829)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 尾崎庄一郎 (80145060)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 渡辺裕 (40114722)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 粟井和夫 (30294573)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 大下慎一郎 (50508132)

# of Collaborated Projects: 1 results

# of Collaborated Products: 22 results
20. 中島拓 (90643792)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
21. 平澤泰 (90284405)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. 前田裕行 (80274075)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. 秋山實利

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. 醍醐弥太郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

KOHNO Nobuoki 河野 修興

Research Projects

Research Products

Co-Researchers

国際共同研究による間質性肺炎の新規バイオマーカーの開発と創薬の試みPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Anti KL-6 antibody enhances the effects of molecular targeted drugPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Comparative studies of a clinical features and genomic analysis in patients with interstitial lung disease and drug induced lung injuryPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The Study on KL-6 as Morbidity Ornamentation Factor and Prognosis Factor of Idiopathic Interstitial Pneumonia.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The Establishment of KL-6 Associated New Serum Markers Using High Sensitive Electrochemiluminescence Immunoassay.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

DEVELOPMENT OF A LUNG CANCER TREATMENT USING ANTI-KL-6/MUC1 MULTI-MONOCLONAL ANTIBODIESPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Clinical Significance of Anti-MUC1 Natural Autoantibody in Sera from Patients with Lung CancerPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Institution

KOHNO Nobuoki 河野修興