Akahori Yasushi 赤堀泰

… Alternative Names

AKAHORI Yasushi 赤堀泰

AKAHORI Yasuaki 赤堀泰

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Researcher Number	80221711
Other IDs
Affiliation (Current)	2025: 三重大学, 医学系研究科, リサーチアソシエイト
Affiliation (based on the past Project Information) *help	2023 – 2024: 三重大学, 医学系研究科, リサーチアソシエイト 2021 – 2022: 三重大学, 医学系研究科, 産学官連携講座講師 2017: 三重大学, 医学系研究科, 特任講師(研究担当) 2016 – 2017: 三重大学, 医学系研究科, 講師 2013: 三重大学, 医学(系)研究科(研究院), 講師 … More 2013: 三重大学, 医学系研究科, 産学官連携講座講師 2007 – 2012: FUJITA HEALTH UNIVERSITY, INSTITUTE FOR COMPREHENSIVE MEDICAL SCIENCE, ASSISTANT PROFESSOR 2006: 藤田保健衛生大学, 総合医科学研究所, 助手 2002 – 2003: 藤田保健衛生大学, 総合医科学研究所, 助手 1996 – 1999: 藤田保健衛生大学, 総合医科学研究所, 助手 Less
Review Section/Research Field	Principal Investigator Basic Section 50020:Tumor diagnostics and therapeutics-related / Tumor therapeutics / General surgery Except Principal Investigator Urology / Basic Section 50020:Tumor diagnostics and therapeutics-related / Basic Section 55010:General surgery and pediatric surgery-related / Immunology
Keywords	Principal Investigator TRAIL-R2 / HER2 / CEA / KDR / キメラ抗原受容体 / MAGE-A4 / TCR様抗体 / 分子認識 / 免疫学 / 共培養 … More / 標的細胞 / スクリーン / scFv / ヒト抗体ライブラリ / off-target / pMHC / screen / antibody library / pMHC complex / TCR-like antibody / CAR / cancer / gastro-intestine / antibody / スクリーニング / 有機溶媒層 / 細胞表面タンパク / 癌抗原 / ヒト抗体ライブラリー / 癌 / 消化器 / 抗体 … More Except Principal Investigator error-prone PCR / ステロイド抗原 / 免疫療法 / 抗体療法 / 腎癌特異抗原 / 完全ヒト型抗体 / 腎細胞癌 / チトクロームC抗原 / CDR / ファージ抗体 / 抗原相補性決定領域 / 抗原抗体反応 / 抗体ライブラリー / off-the-shelf / 細胞免疫療法 / 固形がん / persistence / CAR-T細胞 / 幹細胞様メモリーT細胞 / 同種γδ-T細胞 / 乳癌幹細胞 / CAR-T / 癌幹細胞 / 病理診断 / トリプルネガティブ / 腫瘍浸潤リンパ球 / 乳癌 / GD2 / Phage library / Cancer-specific antigen / Antibody therapy / Renal cell Cancer / 腎癌特異的抗原 / phage-display system / antibody library / CDR framework region / antigen antibody interaactions / recombinant DNA / ヒト型抗体 / error-pronePCR / γ-グロブリン製剤 / 人工抗体 / 抗体-抗体反応 / ヒト抗体 / 抗体レパートリー / ファージディスプレー系 / 抗原の抗体反応 / 組換えDNA / 去勢抵抗性前立腺癌 / 前立腺膜抗原（PSMA） / ファーズデイスプレイ / 癌特異抗原 / 癌特異的抗体 / 前立腺膜特異的抗原 / 抗体 / 癌特異的抗原 / 前立腺膜特異的抗原（PSMA) / 前立腺癌 / 抗体治療 / 腫瘍学 / ステロイド / チトクロームC / エントロピー / モデル構築 / 抗原=抗体反応 / フレームワーク / CDR移植 / 抗原特異性 / 人口抗体 Less

Analysis of tumor supressing function by Hybrid-TCR systemPrincipal Investigator
- Principal Investigator
  
  赤堀泰
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Mie University
Aim to eliminate a bottleneck in the practical realization of anticancer immunotherapy with gene-modified allogeneic gammadelta T cells.
- Principal Investigator
  
  藤原弘
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Mie University
Development of a novel immunotherapy targeting GD2 for the treatment of refractory breast cancer
- Principal Investigator
  
  齋藤佳菜子
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55010:General surgery and pediatric surgery-related
- Research Institution
  Mie University
Development of CAR that can recognize pMHC molecule derived from endogenous antigen of tumor cellsPrincipal Investigator
- Principal Investigator
  
  Akahori Yasushi
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Tumor therapeutics
- Research Institution
  Mie University
Functional analysis of isolated specific antibody to prostate cancer specific antigen using phage-display method
- Principal Investigator
  
  SHIROKI Ryoichi
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Urology
- Research Institution
  Fujita Health University
Analysis of biological function and efficacy of anti EGFR antibodies isolated from screening of human antibody phage display library specific to human renal cell carcinoma
- Principal Investigator
  
  SHIROKI Ryoichi
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Urology
- Research Institution
  Fujita Health University
Analysis of antigen to renal cell carcinoma and establishment of cancer specific antibody teratment
- Principal Investigator
  
  SHIROKI Ryoichi
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Urology
- Research Institution
  Fujita Health University
Basic research for molecular targeting therapy against gastro-intestine cancerPrincipal Investigator
- Principal Investigator
  
  AKAHORI Yasushi
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General surgery
- Research Institution
  Fujita Health University
抗体H鎖CDRIIIのアミノ酸配列と抗原特異性の相関関係の解析
- Principal Investigator
  
  黒澤良和
- Project Period (FY)
  1998
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Fujita Health University
抗体CDRのアミノ酸配列と抗原特異性の相関関係の解析
- Principal Investigator
  
  黒澤良和
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Fujita Health University
Construction of Libraries of antibodies and its application
- Principal Investigator
  
  KUROSAWA Yoshikazu
- Project Period (FY)
  1997 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Immunology
- Research Institution
  Fujit Health University
抗体CDRのアミノ酸配列と抗原特異性の相関関係の解析
- Principal Investigator
  
  KUROSAWA Yoshikazu
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Fujita Health University

All 2023 2018 2017 2016 2013 2012 2009 2008 2007 Other

All Journal Article Presentation

[Journal Article] αβ-T cell receptor transduction gives superior mitochondrial function to γδ-T cells with promising persistence2023
- Author(s)
  Ishihara Mikiya、Miwa Hiroshi、Fujiwara Hiroshi、Akahori Yasushi、Kato Takuma、Tanaka Yoshimasa、Tawara Isao、Shiku Hiroshi
- Journal Title
  
  iScience
  
  Volume: 26 Issue: 10 Pages: 107802-107802
- DOI
  10.1016/j.isci.2023.107802
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K07228, KAKENHI-PROJECT-23K06714, KAKENHI-PROJECT-23K06740, KAKENHI-PROJECT-23K27455
[Journal Article] CAR-Modified Vγ9Vδ2 T Cells Propagated Using a Novel Bisphosphonate Prodrug for Allogeneic Adoptive Immunotherapy2023
- Author(s)
  Yizheng Wang, Linan Wang, Naohiro Seo, Satoshi Okumura, Tae Hayashi, Yasushi Akahori, Hiroshi Fujiwara, Yasunori Amaishi, Sachiko Okamoto, Junichi Mineno, Yoshimasa Tanaka, Takuma Kato, Hiroshi Shiku
- Journal Title
  
  Int J Mol Sci
  
  Volume: 24 Issue: 13 Pages: 10873-10873
- DOI
  10.3390/ijms241310873
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K06714, KAKENHI-PROJECT-23K27455
[Journal Article] Methods for comprehensive identification of membrane proteins recognized by a large number of monoclonal antibodies2009
- Author(s)
  Kurosawa G, Akahori Y(16人中3番目), et al
- Journal Title
  
  J Immunol Methods
  
  Volume: 351 Pages: 1-12
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591870
[Journal Article] Comprehensive screening for antigens overexpressed on carcinoma via isolation of human mAbs that may be therapeutic2008
- Author(s)
  Kurosawa G, Akahori Y, Shiroki R, Hoshinaga K, et al.
- Journal Title
  
  Proceedings of the National Academy of Sciences of the United States of America 105(20)
  
  Pages: 7287-7292
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591870
[Journal Article] Comprehensive screening for antigens overexpressed on carcinoma via isolation of human mAbs that may be therapeutic2008
- Author(s)
  Kurosawa G, Akahori Y(24人中2番目), Shiroki R(24人中20番目), Hoshinaga K(24人中21番目), et al
- Journal Title
  
  Proceedings of the National Academy of Sciences of the United States of America
  
  Volume: 105(20) Pages: 7287-7292
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591870
[Journal Article] Isolation of therapeutic human monoclonal antibodies for varicella-zoster virus and the effect of light chains on the neutralizing activety.2007
- Author(s)
  Suzuki K, Akahori Y, et. al.
- Journal Title
  
  J Med Virol 79
  
  Pages: 852-62
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18591777
[Journal Article] Isolation of therapeutic human monoclonal antibodies for varicella-zoster virus and the effect of light chains on the neutralizing activity2007
- Author(s)
  Suzuki K, Akahori Y, et. al.
- Journal Title
  
  J Med Virol. 79
  
  Pages: 852-62
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18591777
[Journal Article] Comprehensive screening for antigens overexpressed on carcinomas via isolation of human monoclonal antibodies that may be therapeutic
- Author(s)
  Gene Kurosawa, Yasushi Akahoril, Ryoichi Shiroki, Kiyotaka Hoshinaga, Yoshikazu Kurosawa
- Journal Title
  
  Proceedings of the National Academy of Sciences (In press)
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18591777
[Journal Article] Comprehensive screening for antigens overexpressed on carcinomas via isolation of human monoclonal antibodies that may be therapeutic.
- Author(s)
  Gene Kurosawa, Yasushi Akahori, Ryoichi Shiroki, Kiyotaka Hoshinaga, Yoshikazu Kurosawa
- Journal Title
  
  Proceeding of the National Academy of Sciences (In press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18591777
[Journal Article] Comprehensive screening for antigens overexpressed on carcinomas via isolation of human monoclonal antibodies that may be therapeutic.
- Author(s)
  Gene Kurosawa, Yasushi Akahoril, Ryoichi Shiroki, Kiyotaka Hoshinaga, Yoshikazu Kurosawa, et. al.
- Journal Title
  
  Proceedings of the National Academy of Sciences. (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591777
[Presentation] Anti-tumor activity of CAR-T cells targeting the intracellular oncoprotein WT1 can be enhanced by vaccination2018
- Author(s)
  赤堀泰
- Organizer
  がん免疫学会
- Data Source
  KAKENHI-PROJECT-16K14631
[Presentation] Development of TCR-like scFv CAR that recognizes MAGE-A4230-239/HLA-A*02:01 complex2017
- Author(s)
  Yasushi Akahori, Yuya Kato, Yoshihiro Miyahara, Chisaki Amaike, Wang Linam, Takuma Kato, Hiroaki Ikeda, Hiroshi Shiku
- Organizer
  第76回　日本癌学会総会
- Place of Presentation
  パシフィコ横浜(神奈川県横浜市西区みなとみらい１丁目)
- Year and Date
  2017-09-28
- Data Source
  KAKENHI-PROJECT-16K14631
[Presentation] がん精巣抗原MAGE-A4由来ペプチドp230-239をHLA-A*02:01拘束性に認識するTCR様抗体を使用したCARによるがん抑制作用の検討2017
- Author(s)
  赤堀泰　加藤裕也　宮原慶裕　天池千咲　王立楠　加藤琢磨　池田裕明　珠玖洋
- Organizer
  第21回　日本がん免疫学会総会
- Place of Presentation
  幕張メッセ(千葉県千葉市美浜区中瀬２丁目)
- Year and Date
  2017-06-28
- Data Source
  KAKENHI-PROJECT-16K14631
[Presentation] WT1ペプチド-HLA-A24複合体を認識するヒト抗体の単離とそれを用いたCAR治療法の開発2016
- Author(s)
  赤堀泰　米山元裕　池田裕明　宮原慶裕　織戸由紀　王立楠　天石泰典　岡本幸子　峰野純一　竹迫一任　藤原弘　安川正貴　珠玖洋
- Organizer
  第20回　日本がん免疫学会総会
- Place of Presentation
  大阪国際交流センター(大阪市天王寺区上本町8-2-6)
- Year and Date
  2016-07-27
- Data Source
  KAKENHI-PROJECT-16K14631
[Presentation] Isolation of anti PSMA antibody and screening for antigens overexpressed on prostate cancer using anticancer antibodies obtained from antibody phage-display library.2013
- Author(s)
  Hikichi M，Shiroki R，Kurosawa G，Akahori Y，Hoshinaga K，Kurosawa Y.
- Organizer
  33rd Congress of the Societe International Urology.
- Place of Presentation
  Vancouvar, Canada
- Data Source
  KAKENHI-PROJECT-23592353
[Presentation] Isolation of anti PSMA antibody and screening for antigens overexpressed on prostate cancer using anticancer antibodies obtained from antibody phage-display library2013
- Author(s)
  Hikichi M,Shiroki R,Kurosawa G,Akahori Y,Hoshinaga K,Kurosawa Y
- Organizer
  33rd Congress of the Societe International Urology
- Place of Presentation
  Vancouver, Canada
- Data Source
  KAKENHI-PROJECT-23592353
[Presentation] 抗PSMA抗体と様々な癌特異抗原に対する抗体を用いた前立腺臨床検体における発現解析2012
- Author(s)
  引地克、白木良一、赤堀泰、黒澤仁、黒澤良和、星長清隆
- Organizer
  第100回日本泌尿器科学会総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23592353
[Presentation] Analysis of Biological Function of antiEGFR Antibodies Isolated from Screening of Human Antibody Library Specific to Human RCC2009
- Author(s)
  N. Sato, R. Shiroki, Y. Akahori, K. Hoshinaga, 他
- Organizer
  米国泌尿器科学会(AUA)
- Place of Presentation
  米国イリノイ州シカゴ
- Year and Date
  2009-04-27
- Data Source
  KAKENHI-PROJECT-20591870
[Presentation] 腎細胞癌のスクリーニングによりファージ抗体ライブラリーから単離された抗EGFR抗体の機能解析2008
- Author(s)
  佐藤乃理子、白木良一、星長清隆、赤堀康、黒澤良和, 他
- Organizer
  日本泌尿器科学会総会
- Place of Presentation
  横浜
- Year and Date
  2008-04-25
- Data Source
  KAKENHI-PROJECT-20591870

1. KUROSAWA Yoshikazu (10109259)

# of Collaborated Projects: 5 results

# of Collaborated Products: 0 results
2. IBA Yoshitaka (90298547)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
3. SHIROKI Ryoichi (70226330)

# of Collaborated Projects: 3 results

# of Collaborated Products: 10 results
4. HOSHINAGA Kiyotaka (30229174)

# of Collaborated Projects: 3 results

# of Collaborated Products: 10 results
5. 藤原弘 (20398291)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
6. 三輪啓志 (00209967)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
7. 瀬尾尚宏 (50283354)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. 安井久司 (60220141)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 伊藤渉 (50192498)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 百瀬文康 (20798326)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 齋藤佳菜子 (90447871)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 小塚祐司 (50378311)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 小川朋子 (90362334)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 石原幹也 (20707369)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 加藤琢磨 (60224515)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
16. WANG Linan

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
17. 黒沢良和

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results

Akahori Yasushi 赤堀 泰

AKAHORI Yasushi 赤堀 泰

AKAHORI Yasuaki 赤堀 泰

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Analysis of tumor supressing function by Hybrid-TCR systemPrincipal Investigator

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Development of CAR that can recognize pMHC molecule derived from endogenous antigen of tumor cellsPrincipal Investigator

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Basic research for molecular targeting therapy against gastro-intestine cancerPrincipal Investigator

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[Journal Article] αβ-T cell receptor transduction gives superior mitochondrial function to γδ-T cells with promising persistence2023

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[Journal Article] CAR-Modified Vγ9Vδ2 T Cells Propagated Using a Novel Bisphosphonate Prodrug for Allogeneic Adoptive Immunotherapy2023

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[Journal Article] Methods for comprehensive identification of membrane proteins recognized by a large number of monoclonal antibodies2009

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Akahori Yasushi 赤堀泰

AKAHORI Yasushi 赤堀泰

AKAHORI Yasuaki 赤堀泰