OBIKA SATOSHI 小比賀聡

… Alternative Names

OBIKA Satoshi 小比賀聡

小比賀聡オビカサトシ

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Researcher Number	80243252
Other IDs
External Links
Affiliation (Current)	2025: 大阪大学, 大学院薬学研究科, 教授
Affiliation (based on the past Project Information) *help	2022 – 2024: 大阪大学, 大学院薬学研究科, 教授 2020 – 2021: 大阪大学, 薬学研究科, 教授 2016 – 2017: 大阪大学, 大学院薬学系研究科, 教授 2015: 大阪大学, 薬学研究所, 教授 2015: 大阪大学, 薬学研究科, 教授 … More 2014 – 2015: 大阪大学, 大学院薬学研究科, 教授 2011 – 2015: 大阪大学, 薬学研究科(研究院), 教授 2011 – 2013: 大阪大学, 大学院・薬学研究科, 教授 2007 – 2011: Osaka University, Graduate School of Pharmaceutical Sciences, Professor 2006: 大阪大学, 薬学研究科, 助教授 2004 – 2005: 大阪大学, 大学院・薬学研究科, 助手 1998 – 2003: 大阪大学, 薬学研究科, 助手 1998: 大阪大学, 大学院・薬学研究科, 助手 1995 – 1997: 大阪大学, 薬学部, 助手 1993: 大阪大学, 薬学部, 助手 Less
Review Section/Research Field	Principal Investigator Chemistry related to living body / 医薬分子機能学 / Biological pharmacy / Drug development chemistry / Chemical biology / Biological Sciences / Chemical pharmacy Except Principal Investigator Digestive surgery / Biological Sciences / Chemical pharmacy … More / Basic Section 55010:General surgery and pediatric surgery-related / 医薬分子機能学 / Medium-sized Section 55:Surgery of the organs maintaining homeostasis and related fields / General surgery / Pathological medical chemistry / Biomolecular chemistry / Drug development chemistry / Ophthalmology / Medical pharmacy / Analytical chemistry / Hygiene Less
Keywords	Principal Investigator オリゴヌクレオチド / 人工核酸 / 転写制御 / 遺伝子発現制御 / BNA / 合成 / 核酸類縁体 / DNA / 三重鎖核酸 / アンチセンス医薬 … More / 核酸医薬 / アンチジーン / ヌクレオシド / アンチセンス / Triplex DNA / Bridged Nucleic Acids / Control of Gene Expression / Antigene / Oligonucleoides / Nucleic Acids / 架橋型核酸 / 分化 / 動脈硬化症 / 長鎖ノンコーディングRNA / マクロファージ / 動脈硬化 / ノンコーディングRNA / バイオコンジュゲート / アンチセンス核酸 / ゲノム創薬 / 家族性高コレステロール血症 / 筋ジストロフィー / エクソンスキップ / スプライシング制御 / アンチセンス分子 / 高機能性人工核酸 / 有機化学 / 発現制御 / 遺伝子 / 分子認識 / 4重鎖 / 三重鎖 / 核酸 / 遺伝子制御 / 遣伝子制御 / 機能性RNA / レドックス / 光感受性 / 分子スイッチ / DNA切断 / DNAアルキル化 / Tm測定 / 転写因子 / 遺伝子ネットワーク / アンチジーン法 / DNAzyme / オリゴヌクレオチド類緑体 / ヌクレオシド類緑体 / 糖部立体配座 / アンチセンス法 / コンホメーション固定 / RNA切断 / ヌクレオシド類縁体 / 酵素耐性 / Tm / カルバメート結合 / アンチヤンス / 共役redox系 / 不斉還元反応 / NADHモデル化合物 … More Except Principal Investigator BNA / 核酸 / 癌 / アンチセンス / 人工核酸 / ヌクレオシド類縁体 / オリゴヌクレオチド / オリゴヌクレオチド類縁体 / 合成 / 糖部立体配座 / アンチジーン / コンパニオン診断 / アンチセンス核酸医薬 / Transcriptome解析 / Antisense / アンチセンス核酸 / 遺伝子導入 / カチオン性リポソーム / がん / 核酸医薬 / 遺伝子発現制御 / コンホメーション / オリゴヌクレオシド / 細胞接着因子 / PCDHA11 / 胃癌 / オフターゲット探索 / 血行性転移 / 食道癌 / 高機能性人工核酸 / 癌治療核酸医薬 / 消化器癌 / 創薬 / 生体分子 / シグナル伝達 / ゲノム / 臨床 / 遺伝子 / 肝がんマウスモデル / 血管新生 / DDS / アンチセンスオリゴヌクレオチド / 肝臓がん / 抗腫瘍効果 / BNA修飾アンチセンスオリゴヌクレオチド / Vasohibin / 環境応答性 / 刺激応答性 / スイッチ分子 / 核酸アプタマー / キセノ核酸 / Antigene / Synthesis / Artificial nucleic acid / Oligonucleotide analogue / Nucleoside analogue / Sugar conformation / ホスホロアミダート結合 / 酵素耐性 / Gene transfection / Cationic liposome / Chemiluminescence / unnatural amino acids / Pyridoxal model compounds / Antisence / Oligonucleotides / Nucleoside Analogs / 非天然型アミノ酸 / 化学発光 / 非天然アミノ酸 / ピリドキサールモデル化合物 / Gene Delivery / Cationic Liposome / Conformation / Oligonucleotide / Nucleoside Analog / カテオン性脂質 / リポソーム / カチオン性脂質 / 化学合成 / オリゴヌクレオチド誘導体 / 遺伝子医薬品 / ヌクレオシド類緑体 / Robo4 / 炎症 / 敗血症 / 血管内皮細胞 / MCP-1 / マイクログリア / 青色光障害 / 光障害 / MCP-１阻害剤 / 脈絡膜新生血管 / 酸化リン脂質 / マクロファージ / 酸化ストレス / 青色光 / 加齢黄斑変性 / 非コードRNA / RNA activation / 非翻訳領域 / 非コード RNA / ハイブリダイゼーション / 錯生成 / 協同性 / LNA / ターピリジン / 金属錯体 / フェロセン / センサー / 分子認識 / DNAコンジュゲート / 電気化学的制御 / DNAセンサー / 電極修飾 / 電気化学 / 生体分析 / p21 / トリプレックス(三重鎖) / 転写因子 / コンジュゲート / TFO / 膜透過性 / p53 / 転写 / ペプチド / RNase H / ICAM-1 / がん治療 / アンチセンス法 / 核酸類縁体 / アポトーシス / WT-1 / C-ヌクレオシド / アナンチセンス / 三重鎖核酸 / ヌクレオシド / α-アミノ酸のα-アルキル化 / 不斉四級アミノ酸 / ピリドキサール / 補酵素モデル化合物 / NADH / 1,4-ジヒドロピリジン / ケトオキシムの不斉還元 / キラルスルフィニル基 Less

食道癌転移の分子病態解明にもとづいたデュアル修飾型アンチセンス核酸医薬創出研究
- Principal Investigator
  
  神田光郎
- Project Period (FY)
  2024 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 55010:General surgery and pediatric surgery-related
- Research Institution
  Nagoya University
細胞接着因子を標的とするデュアル修飾型アンチセンス核酸を用いた革新的癌治療薬創出
- Principal Investigator
  
  小寺泰弘
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 55010:General surgery and pediatric surgery-related
- Research Institution
  Nagoya University
Development of amido-bridged nucleic acid-modified antisense oligonucleotides to treat gastrointestinal malignancies
- Principal Investigator
  
  KANDA Mitsuro
- Project Period (FY)
  2020 – 2021
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 55:Surgery of the organs maintaining homeostasis and related fields
- Research Institution
  Nagoya University
Development of innovative nucleic acid medicine for gastroenterological cancer
- Principal Investigator
  
  KONNO Masamitsu
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Digestive surgery
- Research Institution
  Osaka University
Development of chip device to detect methylations on microRNAs
- Principal Investigator
  
  Nishida Naohiro
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  General surgery
- Research Institution
  Osaka University
New construction of in vivo reprogramming technology by modified microRNA
- Principal Investigator
  
  ISHII Hideshi
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Digestive surgery
- Research Institution
  Osaka University
Development of liver cancer treatment using Vasohibin-2 targeting antisense oligonucleotide
- Principal Investigator
  
  Horie Sachiko
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Tohoku University
New construction of innovative drug discovery foundation technology for refractory gastrointestinal cancer targeting cancer metabolomics
- Principal Investigator
  
  ISHII Hideshi
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Digestive surgery
- Research Institution
  Osaka University
The identification of long-noncoding RNAs associated with the formation of atherosclerotic plaques and their therapeutic manipulation strategyPrincipal Investigator
- Principal Investigator
  
  OBIKA Satoshi
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Biological pharmacy
- Research Institution
  Osaka University
A novel anti-inflammatory strategy by targeting endothelial cell-specific receptor, Robo4
- Principal Investigator
  
  OKADA Yoshiaki
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Drug development chemistry
- Research Institution
  Osaka University
Creation of xenonucleic acid switch molecules
- Principal Investigator
  
  Kuwahara Masayasu
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biomolecular chemistry
- Research Institution
  Gunma University
Development of platform technologies for antisense oligonucleotide-based therapeutics by a combination of nucleic acids chemistry and information sciencesPrincipal Investigator
- Principal Investigator
  
  Satoshi Obika
- Project Period (FY)
  2012 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Drug development chemistry
- Research Institution
  Osaka University
Developing a novel treatment and primary prevention for age-related macular degeneration based on disease mechanisms
- Principal Investigator
  
  Kamei Motohiro
- Project Period (FY)
  2012 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Ophthalmology
- Research Institution
  Aichi Medical University
  Osaka University
Regulation of RNA Splicing by BNA Antisense OligonucleotidesPrincipal Investigator
- Principal Investigator
  
  OBIKA Satoshi
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Chemical biology
- Research Institution
  Osaka University
Electrochemical regulation of nucleic acids hybridization
- Principal Investigator
  
  IHARA Toshihiro
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Analytical chemistry
- Research Institution
  Kumamoto University
Development of a novel nucleic acid drug targeting sense/antisense transcript pairs
- Principal Investigator
  
  SAKURAI Fuminori
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Medical pharmacy
- Research Institution
  Osaka University
Development of oligonucleotide-based artificial transcription factor based on the higher-order structure of nucleic acidsPrincipal Investigator
- Principal Investigator
  
  OBIKA Satoshi
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Chemistry related to living body
- Research Institution
  Osaka University
遺伝子発現の時空間制御を目的とした外部刺激応答性スイッチの開発Principal Investigator
- Principal Investigator
  
  小比賀聡
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Chemistry related to living body
- Research Institution
  Osaka University
A novel approach for cancer prevention by artificial transcription factor based on peptide engineering
- Principal Investigator
  
  NAKA Hiromi
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Young Scientists (Start-up)
- Research Field
  
  Hygiene
- Research Institution
  Kyoto Prefectural University of Medicine
Control of Gene Expression by Functional and Artificial Nucleic AcidsPrincipal Investigator
- Principal Investigator
  
  OBIKA Satoshi
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Chemistry related to living body
- Research Institution
  Osaka University
先進的ポストゲノム基盤技術開発に向けた機能性人工核酸の創製Principal Investigator
- Principal Investigator
  
  小比賀聡
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Chemistry related to living body
- Research Institution
  Osaka University
がんの遺伝子治療に向けた超機能性人工オリゴヌクレオチドの創製
- Principal Investigator
  
  今西武
- Project Period (FY)
  2003
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Osaka University
標的遺伝子の自在な発現制御を可能とする人工オリゴヌクレオチドの開発Principal Investigator
- Principal Investigator
  
  小比賀聡
- Project Period (FY)
  2001
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Osaka University
がんの遺伝子治療に向けた超機能性人工オリゴヌクレオチドの創製
- Principal Investigator
  
  今西武
- Project Period (FY)
  2001
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Osaka University
がんの遺伝子治療に向けた超機能性人工オリゴヌクレオチドの創製
- Principal Investigator
  
  今西武
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Osaka University
超効率的遺伝子発現制御に向けた人工核酸類の創製Principal Investigator
- Principal Investigator
  
  小比賀聡
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  医薬分子機能学
- Research Institution
  Osaka University
Study to develop novel genomic drugs by using superfunctional oligonucleotide analogues
- Principal Investigator
  
  IMANISHI Takeshi
- Project Period (FY)
  2000 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Osaka University
超機能性合成オリゴヌクレオチドによる特定遺伝子の転写制御法の開発
- Principal Investigator
  
  今西武
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  医薬分子機能学
- Research Institution
  Osaka University
Design and Syntheses of Biologically Functional Molecules Based on the Mechanisms of Life
- Principal Investigator
  
  IMANISHI Takeshi
- Project Period (FY)
  1999 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Osaka University
標的mRNAを特異的に切断するアンチセンス分子の合成と機能Principal Investigator
- Principal Investigator
  
  小比賀聡
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  医薬分子機能学
- Research Institution
  Osaka University
Development of highly functional medicines targeting genomic DNA/RNA
- Principal Investigator
  
  IMANISHI Takeshi
- Project Period (FY)
  1997 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  医薬分子機能学
- Research Institution
  Osaka University
アンチセンス法を指向した新規な核酸類縁体の合成とその機能評価Principal Investigator
- Principal Investigator
  
  小比賀聡
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  医薬分子機能学
- Research Institution
  Osaka University
生物活性を有するアミン類の新しい不斉合成法の開発研究
- Principal Investigator
  
  IMANISHI Takeshi
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Osaka University
キラルなNADHモデル化合物を用いた共役redox系の開発研究Principal Investigator
- Principal Investigator
  
  小比賀聡
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Osaka University

All 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 Other

All Journal Article Presentation Book

[Book] Therapeutic Oligonucleotides : Methods and Protocols2011
- Author(s)
  Y.Hari, T.Kodama, T.Imanishi, S.Obika
- Publisher
  Humana Press
- Data Source
  KAKENHI-PROJECT-21350094
[Book] 核酸医薬の最前線, 和田猛(監)2009
- Author(s)
  小比賀聡
- Total Pages
  11
- Publisher
  シーエムシー出版
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18550151
[Book] バイオ医薬の開発技術とシーズ, 山本重夫(監)2009
- Author(s)
  小比賀聡
- Total Pages
  10
- Publisher
  シーエムシー出版
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18550151
[Journal Article] Evaluation of the effects of chemically different linkers on hepatic accumulations, cell tropism and gene silencing ability of cholesterol-conjugated antisense oligonucleotides2016
- Author(s)
  Wada S., Yasuhara H., Wada F., Sawamura M., Waki R., Yamamoto T., Harada-Shiba M., Obika S.
- Journal Title
  
  J. Control. Release
  
  Volume: 226 Pages: 57-65
- DOI
  10.1016/j.jconrel.2016.02.007
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24249007
[Journal Article] Wavelength-selective light-triggered strand exchange reaction2016
- Author(s)
  Morihiro K., Kodama T., Mori S., Obika S.
- Journal Title
  
  Org. Biomol. Chem.
  
  Volume: 14 Issue: 5 Pages: 1555-1558
- DOI
  10.1039/c5ob02369f
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24249007
[Journal Article] Serial incorporation of a monovalent GalNAc phosphoramidite unit into hepatocyte-targeting antisense oligonucleotides2016
- Author(s)
  Yamamoto T., Sawamura M., Wada F., Harada-Shiba M., Obika S.
- Journal Title
  
  Bioorg. Med. Chem.
  
  Volume: 24 Issue: 1 Pages: 26-32
- DOI
  10.1016/j.bmc.2015.11.036
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24249007
[Journal Article] Amido-bridged nucleic acids with small hydrophobic residues enhance hepatic tropism of antisense oligonucleotides in vivo.2015
- Author(s)
  １．Yamamoto, T., Yahara, A., Waki, R., Yasuhara, H., Wada, F., Harada-Shiba, M. and Obika, S.
- Journal Title
  
  Org Biomol Chem.
  
  Volume: 13 Issue: 12 Pages: 3757-3765
- DOI
  10.1039/c5ob00242g
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25670028, KAKENHI-PROJECT-24249007
[Journal Article] MicroRNAs induce epigenetic reprogramming and suppress malignant phenotypes of human colon cancer cells.2015
- Author(s)
  Ogawa, H., Wu, X., Kawamoto, K., Nishida, N., Konno, M., Koseki, J., Matsui, H., Noguchi, K., Gotoh, N., Yamamoto, T., Miyata, K., Nishiyama, N., Nagano, H., Yamamoto, H., Obika, S., Kataoka, K., Doki, Y., Mori, M., Ishii, H.
- Journal Title
  
  PLoS One.
  
  Volume: 10 Issue: 5 Pages: 1-23
- DOI
  10.1371/journal.pone.0127119
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K15474, KAKENHI-PROJECT-15H04294, KAKENHI-PROJECT-15H05664, KAKENHI-PROJECT-26640072, KAKENHI-PROJECT-26670604, KAKENHI-PROJECT-26293303, KAKENHI-PROJECT-15H05791
[Journal Article] In vitro selection of DNA-based aptamers that exhibit RNA-like conformations using a chimeric oligonucleotide library that contains two different xeno-nucleic acids.2015
- Author(s)
  Hagiwara K, Fujita H, Kasahara Y, Irisawa Y, Obika S, Kuwahara M.
- Journal Title
  
  Mol Biosyst.
  
  Volume: 11(1) Issue: 1 Pages: 71-76
- DOI
  10.1039/c4mb00436a
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25350962
[Journal Article] C5-azobenzene-functionalized locked nucleic acid uridine: isomerization properties, hybridization ability, and enzymatic stability2015
- Author(s)
  Morihiro K., Hasegawa O., Mori S., Tsunoda S., Obika S.
- Journal Title
  
  Org. Biomol. Chem.
  
  Volume: 13 Issue: 18 Pages: 5209-5209
- DOI
  10.1039/c5ob00477b
- Data Source
  KAKENHI-PROJECT-24249007
[Journal Article] Synthesis and Properties of 2’-O,4’-C-Spirocyclopropylene Bridged Nucleic Acid (scpBNA), an Analogue of 2’,4’-BNA/LNA Bearing a Cyclopropane Ring.2015
- Author(s)
  Yamaguchi T., Horiba M., Obika S.
- Journal Title
  
  Chem. Commun.
  
  Volume: 23 Issue: 47 Pages: 33-37
- DOI
  10.1039/c5cc02024g
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24249007, KAKENHI-PROJECT-26810091
[Journal Article] DNA/RNA Heteroduplex Oligonucleotide for Highly Efficient Gene Silencing.2015
- Author(s)
  Nishina K., Piao W., Yoshida-Tanaka K., Sujino Y., Nishina T., Yamamoto T., Nitta K, Yoshioka K, Kuwahara H., Yasuhara H., Baba T., Ono F., Miyata K, Miyake K., P. Seth P., Low A., Yoshida M., Bennett C.F., Kataoka K., Mizusawa H., Obika S. Yokota T.
- Journal Title
  
  Nature Commun.
  
  Volume: 6 Issue: 1 Pages: 7969-7969
- DOI
  10.1038/ncomms8969
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-24249007, KAKENHI-PROJECT-25000006
[Journal Article] Synthesis and Properties of 2'-Deoxyuridine Analogues Bearing Various Azobenzene Derivatives at the C5-Position2015
- Author(s)
  Shohei Mori, Kunihiko Morihiro, Yuuya Kasahara, Shin-ichi Tsunoda, Satoshi Obika
- Journal Title
  
  Chemosensors
  
  Volume: 3 Issue: 2 Pages: 36-54
- DOI
  10.3390/chemosensors3020036
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24249007
[Journal Article] Ca2+ Enrichment in Culture Medium Potentiates Effect of Oligonucleotides.2015
- Author(s)
  Hori S., Yamamoto T., Waki R., Wada S., Wada F., Noda M., Obika S.
- Journal Title
  
  Nuleic Acids Res.
  
  Volume: 43 Issue: 19 Pages: e128-e128
- DOI
  10.1093/nar/gkv626
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24249007
[Journal Article] Synthesis and hybridization property of a boat-shaped pyranosyl nucleic acid containing an exocyclic methylene group in the sugar moiety2015
- Author(s)
  Kazuto Mori, Tetsuya Kodama, Satoshi Obika
- Journal Title
  
  Bioorganic & Medicinal Chemistry
  
  Volume: 23 Issue: 1 Pages: 33-37
- DOI
  10.1016/j.bmc.2014.11.030
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-12J00514, KAKENHI-PROJECT-24249007
[Journal Article] MicroRNAs induce epigenetic reprogramming and suppress malignant phenotypes of human colon cancer cells.2015
- Author(s)
  Ogawa, H., Wu, X., Kawamoto, K., Nishida, N., Konno, M., Koseki, J., Matsui, H., Noguchi, K., Gotoh, N., Yamamoto, T., Miyata, K., Nishiyama, N., Nagano, H., Yamamoto, H., Obika, S., Kataoka, K., Doki, Y., Mori, M., Ishii, H.
- Journal Title
  
  PLoS One.
  
  Volume: 10
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K15496
[Journal Article] Guanidine Bridged Nucleic Acid (GuNA): An Effect of Cationic Bridged Nucleic Acid on DNA Binding Affinity2014
- Author(s)
  A. R. Shrestha, Y. Kotobuki, Y. Hari, S. Obika
- Journal Title
  
  Chem. Commun.
  
  Volume: 50 Issue: 5 Pages: 575-577
- DOI
  10.1039/c3cc46017g
- Data Source
  KAKENHI-PROJECT-24249007
[Journal Article] Photoinduced Changes in Hydrogen Bonding Patterns of 8-Thiopurine Nucleobase Analogues in a DNA Strand.2014
- Author(s)
  K. Morihiro, T. Kodama, S. Mori, S. Obika
- Journal Title
  
  Org. Biomol. Chem.
  
  Volume: 12 Issue: 15 Pages: 2468-2473
- DOI
  10.1039/c3ob42427h
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24249007, KAKENHI-PROJECT-24790110
[Journal Article] Quantitative Evaluation of the Improvement in the Pharmacokinetics of a Nucleic Acid Drug Delivery System by Dynamic PET Imaging with 18F-incorporated Oligodeoxynucleotides2014
- Author(s)
  H. Mukai, D. Ozaki, Y. Cui, T. Kuboyama, H. Yamato-Nagata, K. Onoe, M. Takahashi, Y. Wada, T. Imanishi, T. Kodama, S. Obika,* M Suzuki, H. Doi, Y. Watanabe
- Journal Title
  
  J. Controlled Release
  
  Volume: 180 Pages: 92-99
- DOI
  10.1016/j.jconrel.2014.02.014
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24249007, KAKENHI-PROJECT-25242070
[Journal Article] Sulfonamide-Bridged Nucleic Acid: Synthesis, High RNA Selective Hybridization, and High Nuclease Resistance2014
- Author(s)
  Y. Mitsuoka, Y. Fujimura, R. Waki, A. Kugimiya, T. Yamamoto, Y. Hari, S. Obika
- Journal Title
  
  Organic Letters
  
  Volume: 16 Issue: 21 Pages: 5640-5643
- DOI
  10.1021/ol503029v
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24249007, KAKENHI-PROJECT-25670028
[Journal Article] Light-triggered Strand Exchange Reaction Using the Change in the Hydrogen Bonding Pattern of the Nucleobase Analog2014
- Author(s)
  K. Morihiro, T. Kodama, R. Waki, S. Obika
- Journal Title
  
  Chem. Sci.
  
  Volume: 5 Issue: 2 Pages: 744-750
- DOI
  10.1039/c3sc51987b
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24249007, KAKENHI-PROJECT-24790110
[Journal Article] Locked Nucleic Acid Antisense Inhibitor Trageing Apolipoprotein C-III Efficiently and Preferentially Removes Tryglyceride from Large Very Low-density Lipoprotein Particles in Murine Plasma2014
- Author(s)
  T. Yamamoto, S. Obika, M. Nakatani, H. Yasuhara, F. Wada, E. Shibata, M. Shibata, M. Shiba
- Journal Title
  
  Eur. J. Pharmacol.
  
  Volume: 723 Pages: 353-359
- DOI
  10.1016/j.ejphar.2013.11.004
- Data Source
  KAKENHI-PROJECT-24249007
[Journal Article] PCSK9遺伝子変異による高コレステロール血症（ADH）2013
- Author(s)
  斯波　真理子、山本　剛史、小比賀　聡
- Journal Title
  
  日本臨牀
  
  Volume: 71 Pages: 203-206
- Data Source
  KAKENHI-PROJECT-24249007
[Journal Article] Selenomethylene Locked Nucleic Acid Enables Reversible Hybridization in Response to Redox Changes2013
- Author(s)
  Kunihiko Morihiro
- Journal Title
  
  Angewandte Chemie International Edition
  
  Volume: 52 Issue: 19 Pages: 5074-5078
- DOI
  10.1002/anie.201300555
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-10J03275, KAKENHI-PROJECT-24249007, KAKENHI-PROJECT-24790110
[Journal Article] In vitro selection of BNA (LNA) aptamers.2013
- Author(s)
  Kuwahara M, Obika S.
- Journal Title
  
  Artif DNA PNA XNA.
  
  Volume: 4(2) Issue: 2 Pages: 39-48
- DOI
  10.4161/adna.25786
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25350962
[Journal Article] CE-SELEX Selection of Base- and Sugar-modified DNA Aptamers : Target Binding Dominated by 2', 4'-BNA/LNA Primer2013
- Author(s)
  Yuuya Kasahara, et al.
- Journal Title
  
  Analytical Chemistry
  
  Volume: 85(10) Issue: 10 Pages: 4961-4967
- DOI
  10.1021/ac400058z
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-11J10396, KAKENHI-PROJECT-25350962
[Journal Article] PCSK9 (proprotein convertase subtilisin/kexin type9) 阻害による高コレステロール血症の治療2013
- Author(s)
  斯波　真理子、山本　剛史、小比賀　聡
- Journal Title
  
  内分泌・糖尿病・代謝内科
  
  Volume: 37 Pages: 441-447
- Data Source
  KAKENHI-PROJECT-24249007
[Journal Article] Synthesis and properties of thymidines with six-membered amide bridge2013
- Author(s)
  Hari, Y.; Osawa, T.; Kotobuki, Y.; Shrestha, A. R.; Yahara, A.; Obika, S.
- Journal Title
  
  Bioorg. Med. Chem.
  
  Volume: 21 Issue: 14 Pages: 4405-4412
- DOI
  10.1016/j.bmc.2013.04.049
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22136006, KAKENHI-PROJECT-24249007
[Journal Article] 高機能性アンチセンス分子の局所徐放化による難治性高コレステロール血症治療法の開発2013
- Author(s)
  小比賀　聡
- Journal Title
  
  大阪医薬品協会会報
  
  Volume: 774 Pages: 67-84
- Data Source
  KAKENHI-PROJECT-24249007
[Journal Article] PCSK9阻害薬2013
- Author(s)
  山本　剛史、小比賀　聡、斯波　真理子
- Journal Title
  
  日本臨牀
  
  Volume: 71 Pages: 603-607
- Data Source
  KAKENHI-PROJECT-24249007
[Journal Article] Synthesis and evaluation of novel caged DNA alkylating agents bearing 3, 4-epoxypiperidine structure2012
- Author(s)
  Yuji Kawada, Tetsuya Kodama, Kazuyuki Miyashita, Takeshi Imanishi, Satoshi Obika
- Journal Title
  
  Organic & Biomolecular Chemistry
  
  Volume: (in press) Issue: 26 Pages: 5102-5102
- DOI
  10.1039/c2ob25366f
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21350094
[Journal Article] Synthesis of Selenomethylene-locked Nucleic Acid (SeLNA)-modified Oligonucleotides by Polymerases2012
- Author(s)
  Megan Wheeler
- Journal Title
  
  Chemical Communications
  
  Volume: 48 Issue: 89 Pages: 11020-11022
- DOI
  10.1039/c2cc36464f
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-10J03275, KAKENHI-PROJECT-24249007, KAKENHI-PROJECT-24790110
[Journal Article] Hybridizing ability and nuclease resistance profile of backbone modified cationic phosphorothioate oligonucleotides2012
- Author(s)
  S. M. Abdur Rahman, Takeshi Baba, Tetsuya Kodama, Md. Ariful Islam, Satoshi Obika
- Journal Title
  
  Bioorganic & Medicinal Chemistry
  
  Volume: (in press) Issue: 13 Pages: 4098-4102
- DOI
  10.1016/j.bmc.2012.05.009
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21350094
[Journal Article] Amido-Bridged Nucleic Acids (AmNAs): Synthesis, Duplex Stability, Nuclease Resistance, and In Vitro Antisense Potency2012
- Author(s)
  A. Yahara, A. R. Shrestha, T. Yamamoto, Y. Hari, T. Osawa, M. Yamaguchi, M. Nishida, T. Kodama, S. Obika
- Journal Title
  
  ChemBioChem
  
  Volume: 13 Pages: 2513-2516
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23651236
[Journal Article] Amido-Bridged Nucleic Acids (AmNAs): Synthesis, Duplex Stability, Nuclease Resistance, and in Vitro Antisense Potency2012
- Author(s)
  Aiko Yahara, Ajaya Ram Shrestha, Tsuyoshi Yamamoto, Yoshiyuki Hari, Takashi Osawa, Masaki Yamaguchi, Masaru Nishida, Tetsuya Kodama, Satoshi Obika
- Journal Title
  
  ChemBioChem
  
  Volume: vol.13 Issue: 17 Pages: 2513-2516
- DOI
  10.1002/cbic.201200506
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-12J00549, KAKENHI-PROJECT-24249007, KAKENHI-PROJECT-24790110
[Journal Article] Benzylidene acetal-type bridged nucleic acids : changes in properties upon cleavage of the bridge triggered by external stimuli2011
- Author(s)
  K. Morihiro, T. Kodama, S. Obika
- Journal Title
  
  Chemistry-A European Journal
  
  Volume: 17 Pages: 7918-7926
- Data Source
  KAKENHI-PROJECT-21350094
[Journal Article] Bridged nucleic acid conjugates at 6'-thiol : synthesis, hybridization properties and nuclease resistances2011
- Author(s)
  Kazuto Mori, Tetsuya Kodama, Takeshi Baba, Satoshi Obika
- Journal Title
  
  Organic & Biomolecular Chemistry
  
  Volume: 9 Pages: 5272-5279
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21350094
[Journal Article] Design, synthesis and properties of boat-shaped glucopyranosyl nucleic acid2011
- Author(s)
  Kazuto Mori, Tetsuya Kodama, Satoshi Obika
- Journal Title
  
  Organic Letters
  
  Volume: 13 Pages: 6050-6053
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21350094
[Journal Article] Cleavage of oligonucleotides containing a P3'→N5' phosphoramidite linkage mediated by single-stranded oligonucleotide templates2011
- Author(s)
  Kosuke R. Ito, Tetsuya Kodama, Futaba Makimura, Noritsugu Hosoki, Tomohisa Osaki, Ayao Orita, Takeshi Imanishi, Satoshi Obika
- Journal Title
  
  Molecules
  
  Volume: 16 Pages: 10695-10708
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21350094
[Journal Article] Synthesis and triplex-forming ability of oligonucleotides bearing 1-substituted 1H-1, 2, 3-triazole nucleobases2011
- Author(s)
  Yoshiyuki Hari, Motoi Nakahara, Juanjuan Pang, Masaaki Akabane, Takeshi Kuboyama, Satoshi Obika
- Journal Title
  
  Bioorbganic & Medicinal Chemistry
  
  Volume: 19 Pages: 1162-1166
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21350094
[Journal Article] Synthesis and Triplex-Forming Ability of Oligonucleotides Bearing 1-Substituted 1H-1,2,3-Triazole Nucleobases2011
- Author(s)
  Satoshi Obika, 他5名
- Journal Title
  
  Bioorg.Med.Chem.
  
  Volume: 19 Pages: 1162-1166
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21350094
[Journal Article] A novel bridged nucleoside bearing a conformationally switchable sugar moiety in response to redox changes2010
- Author(s)
  Takeshi Baba, Tetsuya Kodama Kazuto Mori, Takeshi Imanishi, Satoshi Obika
- Journal Title
  
  Chemical Communications
  
  Volume: 46 Pages: 8058-8060
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21350094
[Journal Article] Synergistic Stabilization of Nucleic Acid Assembly by 2'-O, 4'-C-Methylene Bridged Nucleic Acid Modification and Additions of Comb-type Cationic Copolymers2009
- Author(s)
  H. Torigoe, A. Maruyama, S. Obika, T. Imanishi, T. Katayama
- Journal Title
  
  Biochemistry 48
  
  Pages: 3545-3553
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18550151
[Journal Article] Synthesis and Properties of Bridged Nucleic Acids2009
- Author(s)
  S. Obika, T. Imanishi
- Journal Title
  
  Frontier of Development of Nucleic acid Medicine, ed. T. Wada CMC Books, Toky
  
  Pages: 55-66
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18550151
[Journal Article] Synthesis and Properties of 2'-Deoxy-trans-3',4'-BNA Having an S-Type Sugar Puckering2009
- Author(s)
  T. Kodama, K. Sugaya, Y. Harada, Y. Mitsuoka, T. Imanishi, S. Obika
- Journal Title
  
  Heterocycles 77
  
  Pages: 1209-1217
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18550151
[Journal Article] A Bridged Nucleic Acid, 2',4'-BNA^<coc> : Synthesis of Fully Modified Oligonucleotides Bearing Thymine, 5-Methylcytosine, Adenine and Guanine 2',4'-BNA^<coc> Monomers, and RNA-selective Nucleic Acid Recognition2009
- Author(s)
  Y. Mitsuoka, T. Kodama, R. Ohnishi, Y. Hari, T. Imanishi, S. Obika
- Journal Title
  
  Nucleic Acids Res. 37
  
  Pages: 1225-1238
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18550151
[Journal Article] Synthesis of a Novel trans-3',4'-BNA Monomer Bearing a 4,8-Dioxa-5-azabicyclo[5.3.0]decane Skeleton2009
- Author(s)
  T. Kodama, K. Sugaya, T. Baba, T. Imanishi, S. Obika
- Journal Title
  
  Heterocycles 79
  
  Pages: 873-882
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18550151
[Journal Article] Development of an Antisense Oligonucleotide Targeting HCV-IRES by Bridged Nucleic Acids2009
- Author(s)
  S. Obika, T. Imanishi
- Journal Title
  
  Development of Technologies and Seeds for Biological Medicine, ed. S. Yamamoto CMC Books, Tokyo
  
  Pages: 235-245
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18550151
[Journal Article] Synthesis of Several Types of Bridged Nucleic Acids2009
- Author(s)
  S. M. A. Rahman, T. Imanishi, S. Obika
- Journal Title
  
  Chem. Lett 38 (Highlight Review)
  
  Pages: 512-517
- NAID
  10025122435
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18550151
[Journal Article] Design, Synthesis and Evaluation of a Novel Bridged Nucleic Acid, 2',5'-BNA^<ON> with S-type Sugar Conformation Fixed by an N-O Linkage2009
- Author(s)
  T. Kodama, C. Matsuo, H. Ori, T. Miyoshi, S. Obika, K. Miyashita, T. Imanishi
- Journal Title
  
  Tetrahedron 65
  
  Pages: 2116-2123
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18550151
[Journal Article] Systematic Analysis of Enzymatic DNA Polymerization Using Oligo-DNA Templates and Triphosphate Analogs Involving 2',4'-Bridged Nucleosides2008
- Author(s)
  M. Kuwahara, S. Obika, J. Nagashima, Y. Ohta, Y. Suto, H. Ozaki, H. Sawai, T. Imanishi
- Journal Title
  
  Nucleic Acids Res. 36
  
  Pages: 4257-4265
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18550151
[Journal Article] Design, Synthesis and Properties of 2',4'-BNA: A Bridged Nucleic Acid Analogue2008
- Author(s)
  S. M. A. Rahman, S. Seki, S. Obika, H. Yoshikawa, K. Miyashita, T. Imanishi
- Journal Title
  
  J. Am. Chem. Soc 130
  
  Pages: 4886-4896
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18550151
[Journal Article] Synthesis and Properties of 3'-Amino-2', 4'-BNA, A Bridged Nucleic Acid with a N3'→P5' Phosphoramidate Linkage2008
- Author(s)
  S. Obika, et al.
- Journal Title
  
  Bioore Med. Chem. 16
  
  Pages: 9230-9237
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18550151
[Journal Article] Promotion of Acid-Mediated P-N Bond Cleavage of 5'-Amino-2',4'-BNA2008
- Author(s)
  S. Obika, M. Tomizu, Y. Negoro, A. Orita, T. Imanishi
- Journal Title
  
  Collection Symp. Sen 10
  
  Pages: 423-425
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18550151
[Journal Article] Biologically active 2-5A analogs containing 3'-O,4'-C-propylene adenosine as potent Rnase L agonists2008
- Author(s)
  K. Morita, S. Obika, T. Imanishi, Y. Kitade, M. Koizumi
- Journal Title
  
  Nucleic Acids Symp. Ser. 52
  
  Pages: 637-638
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18550151
[Journal Article] Recognition of T-A Interruption by 2', 4'-BNAs Bearing Heteroaromatic Nucleobases Through Parallel Motif Triplex Formation2008
- Author(s)
  S. Obika, et al.
- Journal Title
  
  Bioorg. Med. Chem. 16
  
  Pages: 2945-2954
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18550151
[Journal Article] Recognition of T・A Interruption by 2', 4'-BNAs Bearing Heteroaxomatic Nucleobases Through Parallel Motif Triplex Formation2008
- Author(s)
  S. Obika, et al.
- Journal Title
  
  Bioorg. Med. Chem. 16
  
  Pages: 2945-2954
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18550151
[Journal Article] Recognition of T・A Interruption by 2',4'-BNAs Bearing Heteroaromatic Nucleobases Through Parallel Motif Triplex Formation2008
- Author(s)
  S. Obika, H. Inohara, Y. Hari, T. Imanishi
- Journal Title
  
  Bioorg. Med. Chem. 16
  
  Pages: 2945-2954
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18550151
[Journal Article] Synthesis and Properties of 3'-Amino-2', 4'-BNA, A Bridged Nucleic Acid with a N3'→P5' Phosphoramidate Linkage2008
- Author(s)
  S. Obika, et al.
- Journal Title
  
  Bioorg. Med. Chem. 16
  
  Pages: 9230-9237
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18550151
[Journal Article] Design and Chemical Synthes is of a 2',4'-BNA Probe for 7,8-Dihydro-8-oxoguanine-containing Double Stranded DNA2008
- Author(s)
  T. Miyoshi, T. Kodama, S. Obika, T. Imanishi
- Journal Title
  
  Nucleic Acids Symp. Ser. 52
  
  Pages: 305-306
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18550151
[Journal Article] Synthesis and Properties of 3'-Amino-2',4'-BNA, A Bridged Nucleic Acid with a N3' →P5' Phosphoramidate Linkage2008
- Author(s)
  S. Obika, S. M. A. Rahman, B. Song, M. Onoda, M. Koizumi, K. Morita, T. Imanishi
- Journal Title
  
  Bioorg. Med. Chem. 16
  
  Pages: 9230-9237
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18550151
[Journal Article] Promotion of Triplex Formation by 2'-O,4'-C-Aminomethylene Bridged Nucleic Acid (2',4'-BNA^<NC>) Modification2008
- Author(s)
  K. Sasaki, S. M. A. Rahman, S. Obika, T. Imanishi, H. Torigoe
- Journal Title
  
  Nucleic Acids Symp. Ser. 52
  
  Pages: 419-420
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18550151
[Journal Article] Promotion of Acid-Mediated P-N Bond Cleavage of 5'-Amino-2', 4'-BNA Oligonucleotides by Triplex Formation : Effects of Neighboring Residues2008
- Author(s)
  S. Obika, et al.
- Journal Title
  
  Collection Symp. Ser. 10
  
  Pages: 423-425
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18550151
[Journal Article] N-Methyl Substituted 2',4'-BNA^<NC> : A Highly Nuclease-resistant Nucleic Acid Analogue with High-affinity RNA Selective Hybridization2007
- Author(s)
  K. Miyashita, S. M. A. Rahman, S. Seki, S. Obika, T. Imanishi
- Journal Title
  
  Chem. Commun.
  
  Pages: 3765-3767
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18550151
[Journal Article] Double-stranded DNA-teraplated Oligonucleotide Digestion Triggered by Triplex Formation2007
- Author(s)
  S. Obika, et al.
- Journal Title
  
  ChemBioChem 8
  
  Pages: 1924-1928
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18550151
[Journal Article] Development of a Novel Nucleoside Analogue with S-type Sugar Conformation : 2'-Deoxy-trans-3',4'-Bridged Nucleic Acids2007
- Author(s)
  T. Osaki, S. Obika, Y. Harada, Y. Mitsuoka, K. Sugaya, M. Sekiguchi, T. Imanishi
- Journal Title
  
  Tetrahedron 63
  
  Pages: 8977-8986
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18550151
[Journal Article] Synthesis of Novel 2'-Deoxy Type trans-3',4'-Bridged Nucleic Acid2007
- Author(s)
  T. Osaki, S. Obika, Y. Harada, Y. Mitsuoka, K. Sugaya, M. Sekiguchi, R. Somjing, T. Imanishi
- Journal Title
  
  Nucleosides Nucleotides Nucleic Acids 26
  
  Pages: 1079-1082
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18550151
[Journal Article] Biologically Stable 2-5A Analogues Containing 3'-O,4'-C-Bridged Adenosine as Potent RNase L Agonists2007
- Author(s)
  K. Morita, M. Kaneko, S. Obika, T. Imanishi, Y. Kitade, M. Koizumi
- Journal Title
  
  ChemMedChem 2
  
  Pages: 1703-1707
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18550151
[Journal Article] Acid-mediated cleavage of oligonucleotide P3'→N5' phosphoramidates triggered by sequence-specific triplex formation2007
- Author(s)
  S.Obika et al.
- Journal Title
  
  Nucleosides, Nucleotides and Nucleic Acids (in press)
- Data Source
  KAKENHI-PROJECT-18550151
[Journal Article] Synthesis and Chemical Properties of a Novel 2',4'-Bridged Nucleic Acid Analogue with a Seven-membered Cyclic Carbamate Structure2007
- Author(s)
  M. Nishida, T. Kodama, S. Obika, T. Imanishi
- Journal Title
  
  Nucleic Acids Symp. Ser. 51
  
  Pages: 157-158
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18550151
[Journal Article] Synthesis and Properties of a 2'-Deoxy Analogue of trans-3',4'-BNA with an S-type Sugar Conformation2007
- Author(s)
  K. Sugaya, Y. Harada, Y. Mitsuoka, T. Osaki, S. Obika, T. Kodama, T. Imanishi
- Journal Title
  
  Nucleic Acids Symp. Ser. 51
  
  Pages: 155-156
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18550151
[Journal Article] Highly Stable Pyrimidine-motif Triplex Formation at Physiological pH Values by a Bridged Nucleic Acid Analogue2007
- Author(s)
  S. M. A. Rahman, S. Seki, S. Obika, K. Miyashita, T. Imanishi
- Journal Title
  
  Angew. Chem. 119
  
  Pages: 4384-4387
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18550151
[Journal Article] 2',4'-BNA^<NC> : A Novel Bridged Nucleic Acid Analogue with Excellent Hybridizing and Nuclease Resistance Profiles2007
- Author(s)
  S. M. A. Rahman, S. Seki, K. Utsuki, S. Obika, K. Miyashita, T. Imanishi
- Journal Title
  
  Nucleosides Nucleotides Nucleic Acids 26
  
  Pages: 1625-1628
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18550151
[Journal Article] Polymerisation of a DNA Strand Using Oligo-DNA Template with Modified Bases, Sugars and Phosphates2007
- Author(s)
  J. Nagashima, S. Minezaki, S. Obika, T. Imanishi, M. Kuwahara, H. Sawai
- Journal Title
  
  Nucleic Acids Symp. Ser. 51
  
  Pages: 55-56
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18550151
[Journal Article] 核酸医薬 : テーラーメード医療に向けた新たな創薬2007
- Author(s)
  小比賀聡
- Journal Title
  
  薬事日報
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18550151
[Journal Article] Highly Stable Pyrimidine-motif Triplex Formation at Physiological pH Values by a Bridged Nucleic Acid Analogue2007
- Author(s)
  S. M. A. Rahman, S. Seki, S. Obika, K. Miyashita, T. Imanishi
- Journal Title
  
  Angew. Chem. Int. Ed 46
  
  Pages: 4306-4309
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18550151
[Journal Article] Inhibition of bcl-xL Expression by Antisense Oligonucleotides Containing Various Bridged Nucleic Acids (BNAs)2007
- Author(s)
  S. Roongjang, K. Takahashi, S. Obika, T. Imanishi
- Journal Title
  
  Nucleic Acids Symp. Ser. 51
  
  Pages: 113-114
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18550151
[Journal Article] Antisense Activity of 2',4'-BNA Targeted to PPAR Gamma in THP-1 and HCT116 Cells2007
- Author(s)
  K. Tachibana, T. Katayama, C. Ueda, M. Sumitomo, M. Tagami, K. Ishimoto, D. Yamasaki, T. Tanaka, T. Hamakubo, J. Sakai, T. Kodama, S. Obika, T. Imanishi, T. Doi
- Journal Title
  
  Nucleic Acids Symp. Ser. 51
  
  Pages: 441-442
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18550151
[Journal Article] Acid-mediated Cleavage of Oligonucleotide P3'→N5' Phosphoramidates Triggered by Sequence-specific Triplex Formation2007
- Author(s)
  S. Obika, M. Tomizu, Y. Negoro, T. Osaki, A. Orita, Y. Ueyama, O. Nakagawa, T. Imanishi
- Journal Title
  
  Nucleosides Nucleotides Nucleic Acids 26
  
  Pages: 893-896
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18550151
[Journal Article] Synthesis and Evaluation of a Novel 2',5'-Bridged Nucleic Acid with Sugar Conformation Fixed to S-type by N-0 Linkage2007
- Author(s)
  T. Kodama, C. Matsuo, H. Ori, S. Obika, K. Miyashita, T. Imanishi
- Journal Title
  
  Nucleic Acids Symp. Ser. 51
  
  Pages: 159-160
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18550151
[Journal Article] Double-stranded DNA-templated Oligonucleotide Digestion Triggered by Triplex Formation2007
- Author(s)
  S. Obika, M. Tomizu, Y. Negoro, A. Orita, 0. Nakagawa, T. Imanishi
- Journal Title
  
  ChemBioChem 8
  
  Pages: 1924-1928
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18550151
[Journal Article] Acid-mediated cleavage of oligonucleotide P3'→N5' phosphoramidates triggered by sequence-specific triplex formation2007
- Author(s)
  S. Obika, et al.
- Journal Title
  
  Nucleosides, Nucleotides and Nucleic Acids 26
  
  Pages: 893-896
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18550151
[Journal Article] Synthesis and Properties of 2'-O,4'-C-Methyleneoxymethylene Bridged Nucleic Acid2006
- Author(s)
  Y.Hari, S.Obika, R.Ohnishi, K.Eguchi, T.Osaki, H.Ohishi, T.Imanishi
- Journal Title
  
  Bioorg.Med.Chem. 14
  
  Pages: 1029-1038
- Data Source
  KAKENHI-PROJECT-16750145
[Journal Article] Synthesis of 2',4'-BNA^<coc> Bearing a Purine Nucleobase2006
- Author(s)
  Y. Mitsuoka, R. Ohnishi, Y. Hari, S. Obika, T. Imanishi
- Journal Title
  
  Nucleic Acids Symp. Ser. 50
  
  Pages: 13-14
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18550151
[Journal Article] ゲノム創薬の高機能性基盤素材としての新しいブリッジ型人工核酸BNA2006
- Author(s)
  今西武, 小比賀聡
- Journal Title
  
  化学工業 57
  
  Pages: 192-197
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18550151
[Journal Article] High-affinity RNA Mimicking Binding of 2',4'-BNA^<NC> Towards Complementary Strands : A Comparative Study with 2',4'-BNA/LNA2006
- Author(s)
  S. M. A. Rahman, S. Seki, K. Utsuki, S. Obika, K. Miyashita, T. Imanishi
- Journal Title
  
  Nucleic Acids Symp. Ser. 50
  
  Pages: 195-196
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18550151
[Journal Article] Antisense Activity of 2',4'-BNA Targetd to bcl-xL Gene in HepG2 Cell2006
- Author(s)
  S. Roongjang, K. Takahashi, M. Park, S. Obika, T. Imanishi
- Journal Title
  
  Nucleic Acids Symp. Ser. 50
  
  Pages: 289-290
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18550151
[Journal Article] Synthesis and Properties of a Novel Bridged Nucleic Acid Analogue, 5'-Ammo-3',5'-BNA2005
- Author(s)
  M.Sekiguchi, S.Obika, R.Somjing, T.Imanishi
- Journal Title
  
  Nucleosides Nucleotides Nucleic Acids 24
  
  Pages: 1097-1100
- Data Source
  KAKENHI-PROJECT-16750145
[Journal Article] Presence of 2', 5'-Linkages in a Homopyrimidine DNA Oligonucleotide Promotes Stable Triplex Formation under Physiological Conditions2005
- Author(s)
  S.Obika, A.Hiroto, O.Nakagawa, T.Imanishi
- Journal Title
  
  Nucleosides Nucleotides Nucleic Acids 24
  
  Pages: 1055-1058
- Data Source
  KAKENHI-PROJECT-16750145
[Journal Article] Synthesis and Triplex-forming Ability of 2',4'-BNAs Bearing Imidazoles as a Nucleobase2005
- Author(s)
  Y.Hari, S.Obika, H.Inohara, D.Une, T.Imanishi
- Journal Title
  
  Chem.Pharm.Bull. 53
  
  Pages: 843-846
- NAID
  10016655278
- Data Source
  KAKENHI-PROJECT-16750145
[Journal Article] Promotion of Stable Triplex Formation by Partial Incorporation of 2',5'-Phosphodiester Linkages into Triplex-forming Oligonucleotides2005
- Author(s)
  S.Obika, A.Hiroto, O.Nakagawa, T.Imanishi
- Journal Title
  
  Chem.Commun.
  
  Pages: 2793-2795
- Data Source
  KAKENHI-PROJECT-16750145
[Journal Article] Adjustment of the γ Dihedral Angle of an Oligonucleotide P3'→N5' Phosphoramidate Enhances Its Binding Affinity towards Complementary Strands2005
- Author(s)
  S.Obika, M.Sekiguchi, R.Somjing, T.Imanishi
- Journal Title
  
  Angew.Chem.Int.Ed. 44
  
  Pages: 1944-1947
- Data Source
  KAKENHI-PROJECT-16750145
[Journal Article] Synthesis and properties of a novel bridged nucleic acid analogue bearing a P3'->N5' phosphoramidate linkage, 5'-amino-3',5'-BNA2004
- Author(s)
  M.Sekiguchi, S.Obika, R.Somjing, T.Imanishi
- Journal Title
  
  Nucleic Acids Symposium Series 48
  
  Pages: 7-8
- Data Source
  KAKENHI-PROJECT-16750145
[Journal Article] 2',4'-BNA derivatives bearing an unnatural nucleobase : Synthesis and application to triplex-forming oligonucleotides2004
- Author(s)
  H.Inohara, S.Obika, T.Imanishi
- Journal Title
  
  Nucleic Acids Symposium Series 48
  
  Pages: 63-64
- Data Source
  KAKENHI-PROJECT-16750145
[Journal Article] Synthesis and conformation of a novel bridged nucleic acid having a trans-fused 3,5,8-trioxabicyclo[5.3.0]decane structure2004
- Author(s)
  S.Obika, T.Osaki, M.Sekiguchi, R.Somjing, Y.Harada, T.Imanishi
- Journal Title
  
  Tetrahedron Letters 45, 24
  
  Pages: 4801-4804
- Data Source
  KAKENHI-PROJECT-16750145
[Journal Article] Development of bridged nucleic acid analogues for antigene technology2004
- Author(s)
  Satoshi Obika
- Journal Title
  
  Chem.Pharm.Bull. 52
  
  Pages: 1399-1404
- NAID
  110003665463
- Data Source
  KAKENHI-PROJECT-16750145
[Journal Article] Synergistic stabilization of triplex by combination of comb-type cationic copolymer and 2',4'-BNA2004
- Author(s)
  T.Katayama, A.Maruyama, S.Obika, T.Imanishi, H.Torigoe
- Journal Title
  
  Nucleic Acids Symposium Series 48
  
  Pages: 165-166
- Data Source
  KAKENHI-PROJECT-16750145
[Journal Article] ゲノムテクノロジー基盤素材としての架橋型人工核酸BNA2004
- Author(s)
  Satoshi Obika
- Journal Title
  
  薬学雑誌 124
  
  Pages: 781-790
- NAID
  110003666134
- Data Source
  KAKENHI-PROJECT-16750145
[Presentation] Vasohibin-2標的性BNAアンチセンスの肝がんに対する抗腫瘍効果の評価2016
- Author(s)
  堀江佐知子、鈴木康弘、小林美穂、小玉哲也、小比賀聡、佐藤靖史
- Organizer
  第11回バソヒビン研究会
- Place of Presentation
  ラフォーレ蔵王 (蔵王)
- Year and Date
  2016-01-23
- Data Source
  KAKENHI-PROJECT-26860205
[Presentation] 肝臓癌に対するVasohibin-2標的BNA【LNA】修飾アンチセンスオリゴヌクレオチドの抗腫瘍効果の評価2016
- Author(s)
  堀江佐知子、鈴木康弘、小林美穂、小玉哲也、小比賀聡、佐藤靖史
- Organizer
  第2回血管生物若手研究会
- Place of Presentation
  東北大学加齢医学研究所 (仙台)
- Year and Date
  2016-03-04
- Data Source
  KAKENHI-PROJECT-26860205
[Presentation] Synthesis and hybridization property of a boat-shaped pyranosyl nucleic acid analogue whose nucleobase orientation is similar to that of natural RNA2015
- Author(s)
  Kanagawa T., Mori K., Kodama T., Obika S.
- Organizer
  PACIFICHEM 2015
- Place of Presentation
  米国・ハワイ・ホノルル
- Year and Date
  2015-12-15
- Data Source
  KAKENHI-PROJECT-24249007
[Presentation] Recent Progress in the Development of Bridged Nucleic Acids2015
- Author(s)
  Obika S
- Organizer
  PACIFICHEM 2015
- Place of Presentation
  米国・ハワイ・ホノルル
- Year and Date
  2015-12-15
- Data Source
  KAKENHI-PROJECT-24249007
[Presentation] 架橋型ヌクレオチドからなるキセノ核酸の酵素的合成2015
- Author(s)
  笠井達郎，片岡由佳，藤田博仁，本田直渡，笠原勇矢，小比賀聡，桑原正靖
- Organizer
  日本化学会第94春季年会(2015)
- Place of Presentation
  日本大学理工学部船橋キャンパス/薬学部
- Year and Date
  2015-03-27
- Data Source
  KAKENHI-PROJECT-25350962
[Presentation] mRNA structure prediction targeting antisense oligonucleotides (AONs).2015
- Author(s)
  Yamashita M., Kawashita N., Yamamoto T., Okamoto K., Takagi T., Obika S.
- Organizer
  PACIFICHEM 2015
- Place of Presentation
  米国・ハワイ・ホノルル
- Year and Date
  2015-12-15
- Data Source
  KAKENHI-PROJECT-24249007
[Presentation] Vasohibin-2標的性BNA修飾アンチセンスオリゴヌクレオチドによる肝がん治療の開発2015
- Author(s)
  堀江佐知子、鈴木康弘、小林美穂、小玉哲也、小比賀聡、佐藤靖史
- Organizer
  第23回血管生物医学会
- Place of Presentation
  神戸国際会議場 (神戸)
- Year and Date
  2015-12-10
- Data Source
  KAKENHI-PROJECT-26860205
[Presentation] セレノメチレン架橋型ピリミジンヌクレオシドで修飾したアンチセンス分子2015
- Author(s)
  兒玉哲也，百相義大，森廣邦彦，廣明秀一，小比賀聡
- Organizer
  日本核酸医薬学会第1回年会
- Place of Presentation
  京都市
- Year and Date
  2015-11-30
- Data Source
  KAKENHI-PROJECT-24249007
[Presentation] 舟形固定した L-リキソースを糖部に有する人工核酸の相補鎖結合親和性 ―塩基の回転角が核酸二重鎖安定性に及ぼす影響―2015
- Author(s)
  金川峻幸、森和土、兒玉哲也、小比賀聡
- Organizer
  第65回日本薬学会近畿支部大会
- Place of Presentation
  大阪府富田林市（大阪大谷大学）
- Year and Date
  2015-10-17
- Data Source
  KAKENHI-PROJECT-24249007
[Presentation] 核酸医薬開発におけるこれからの化学2015
- Author(s)
  小比賀聡
- Organizer
  日本核酸医薬学会第1回年会
- Place of Presentation
  京都市
- Year and Date
  2015-11-30
- Data Source
  KAKENHI-PROJECT-24249007
[Presentation] スピロシクロプロパン導入型2',4'-BNA/LNAの合成と特性評価2014
- Author(s)
  堀場昌彦、山口卓男、小比賀聡
- Organizer
  日本薬学会第134年会（熊本）
- Place of Presentation
  熊本大学（熊本）
- Data Source
  KAKENHI-PROJECT-24249007
[Presentation] Prediction of antisense efficacy using sequence motifs and neural network2014
- Author(s)
  Mako Kitani, Norihito Kawashita, Tsuyoshi Yamamoto, Maki Yamashita, Kousuke Okamoto, Tatsuya Takagi, Satoshi Obika
- Organizer
  International Chemometrics Research Meeting 2014
- Place of Presentation
  Berg en Dal, the Netherlands
- Year and Date
  2014-09-15
- Data Source
  KAKENHI-PROJECT-24249007
[Presentation] 肝臓内取り込みの上昇を目的としたコレステロール修飾型アンチセンス核酸の体内及び、肝臓内動態解析2014
- Author(s)
  和田郁人、山本剛史、斯波真理子、小比賀聡
- Organizer
  日本薬学会第134年会
- Place of Presentation
  熊本大学（熊本）
- Data Source
  KAKENHI-PROJECT-24249007
[Presentation] Synthesis and evaluation of Base locked Nucleic Acid (BlNA): the effect of fixing glycosidic torsion angle.2014
- Author(s)
  Hara Takashi, Kodama Tetsuya, Mori Kazuto, Obika Satoshi
- Organizer
  The 41st International Symposium on Nucleic Acids Chemistry
- Place of Presentation
  北九州
- Year and Date
  2014-11-05
- Data Source
  KAKENHI-PROJECT-24249007
[Presentation] 3H2型シクロヘキセニル核酸の設計と合成、及び機能性評価2014
- Author(s)
  百相義大、武田修一、松本友治、廣明秀一、小比賀聡、兒玉哲也
- Organizer
  第60回日本薬学会東海支部大会
- Place of Presentation
  鈴鹿
- Year and Date
  2014-07-05
- Data Source
  KAKENHI-PROJECT-24249007
[Presentation] Switch molecules designed from 2′,4′-BNA aptamers2013
- Author(s)
  Yuuya Kasahara， Yuuta Irisawa， Naoto Honda， Kunihiko Morihiro， Satoshi Obika， Masayasu Kuwahara
- Organizer
  The 40th International Symposium on Nucleic Acids Chemistry 2013 (ISNAC2014)
- Place of Presentation
  神奈川大学
- Data Source
  KAKENHI-PROJECT-25350962
[Presentation] 架橋型アンチセンス核酸の体内動態に関する定量的評価2013
- Author(s)
  安原秀典、山本剛史、斯波真理子、小比賀聡
- Organizer
  第２３回アンチセンスシンポジウム
- Place of Presentation
  徳島大学（徳島）
- Data Source
  KAKENHI-PROJECT-24249007
[Presentation] 架橋型シクロヘキセニル核酸の合成と評価2013
- Author(s)
  百相義大、廣明秀一、小比賀聡、兒玉哲也
- Organizer
  第２３回アンチセンスシンポジウム
- Place of Presentation
  徳島大学（徳島）
- Data Source
  KAKENHI-PROJECT-24249007
[Presentation] Syntheses and properties of nucleic acids having constrained pyranose as the sugar moiety2013
- Author(s)
  Kazuto Mori, Tetsuya Kodama, Satoshi Obika
- Organizer
  The 40th International Symposium on Nucleic Acids Chemistry 2013
- Place of Presentation
  神奈川大学（神奈川）
- Data Source
  KAKENHI-PROJECT-24249007
[Presentation] 2',4'-BNA/LNAプライマー依存性キメラ型人工核酸アプタマーの構造と機能2013
- Author(s)
  笠原勇矢，入澤祐太，本田直渡，森廣邦彦，小比賀聡，桒原正靖
- Organizer
  第7回バイオ関連化学シンポジウム2013
- Place of Presentation
  名古屋大学豊田講堂・野依学術交流館
- Data Source
  KAKENHI-PROJECT-25350962
[Presentation] CE-SELEX OF CHIMERIC DNA-BASED APTAMERS2013
- Author(s)
  Yuuya Kasahara， Yuuta Irisawa， Naoto Honda， Satoshi Obika，Masayasu Kuwahara
- Organizer
  Frontiers of Single Cell Analysis Conference
- Place of Presentation
  Stanford University, Stanford, CA, USA
- Data Source
  KAKENHI-PROJECT-25350962
[Presentation] Effect of various substituent groups on amido-bridged nucleic acids (AmNAs) modified antisense oligonucleotides on pharmaceutical benefits and accumulation in liver2013
- Author(s)
  Reiko Waki, Tsuyoshi Yamamoto, Aiko Yahara, Hidenori Yasuhara, Mariko Harada-Shiba, Satoshi Obika
- Organizer
  The 9th Annual Meeting of the Oligonucleotide Therapeutic Society
- Place of Presentation
  Royal Continental Hotel (Napoli, Italy)
- Data Source
  KAKENHI-PROJECT-24249007
[Presentation] Selenomethylene Locked Nucleic Acid (SeLNA) Bearing a Purine Base2013
- Author(s)
  Yoshihiro Moai, Tetsuya Kodama, Kunihiko Morihiro, Hidekazu Hiroaki, Satoshi Obika
- Organizer
  The 40th International Symposium on Nucleic Acids Chemistry 2013
- Place of Presentation
  神奈川大学（神奈川）
- Data Source
  KAKENHI-PROJECT-24249007
[Presentation] Antisense Oligonucleotide with Adequate Affinity Hopscotches Across Target RNAs in RNase H-mediated Mechanism2013
- Author(s)
  Tsuyoshi Yamamoto, Naoko Fujii, Naoya Shigesada, Satoshi Obika
- Organizer
  The 9th Annual Meeting of the Oligonucleotide Therapeutic Society
- Place of Presentation
  Royal Continental Hotel (Napoli, Italy)
- Data Source
  KAKENHI-PROJECT-24249007
[Presentation] さまざまな置換基を施したアミド架橋型人工核酸の in vitro 機能評価2013
- Author(s)
  脇玲子、山本剛史、矢原愛子、安原秀典、斯波真理子、田原早織、川上純司、小比賀聡
- Organizer
  第２３回アンチセンスシンポジウム
- Place of Presentation
  徳島大学（徳島）
- Data Source
  KAKENHI-PROJECT-24249007
[Presentation] Amido-bridged Nucleic Acid: Synthesis, Duplex Stability,Nuclease Resistance, and In Vitro Antisense Potency2012
- Author(s)
  A. Yahara, A. R. Shrestha, T . Yamamoto, Y . Hari, T . Osawa, M. Yamaguchi, M.Nishida, T . Kodama, S. Obika
- Organizer
  8th Annual Meeting of the Oligonucleotide Therapeutics Society
- Place of Presentation
  Boston (USA)
- Data Source
  KAKENHI-PROJECT-23651236
[Presentation] Investigation of the factor affecting the duplex-forming ability of boat-shaped glucopyranosyl nucleic acid2012
- Author(s)
  Kazuto Mori, Tetsuya Kodama, Satoshi Obika
- Organizer
  XX International Round Table on Nucleosides, Nucleotides and Nucleic Acids
- Place of Presentation
  カナダ、モントリオール
- Data Source
  KAKENHI-PROJECT-24249007
[Presentation] Synthesis and properties of a nucleic acid bearing boat-shaped pyranose sugar2012
- Author(s)
  Kazuto Mori, Tetsuya Kodama, Satoshi Obika
- Organizer
  13th Tetrahedron Symposium - Asia Edition
- Place of Presentation
  台湾、台北
- Data Source
  KAKENHI-PROJECT-24249007
[Presentation] Synthesis and properties of guanidine-bridged nucleic acid: The effect of cationic bridge on duplex stability2012
- Author(s)
  Yutaro Kotobuki, Yoshiyuki Hari, Ajaya R. Shrestha, Satoshi Obika
- Organizer
  The 39th Internatinal Symposium on Nucleic Acids Chemistry
- Place of Presentation
  愛知県名古屋市
- Data Source
  KAKENHI-PROJECT-24249007
[Presentation] 新規架橋型人工核酸の合成と機能評価;グアニジノ基による架橋部へのカチオン導入の効果2012
- Author(s)
  壽悠太郎, 張功幸, Shrestha Ajaya Ram, 小比賀聡
- Organizer
  アンチセンス・遺伝子・デリバリーシンポジウム2012
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-23651236
[Presentation] 光刺激により糖部架橋構築が誘起される人工核酸の開発2012
- Author(s)
  肯特夫, 森廣邦彦, 兒玉哲也, 小比賀聡
- Organizer
  第132回日本薬学会年会
- Place of Presentation
  北海道大学(札幌)
- Year and Date
  2012-03-31
- Data Source
  KAKENHI-PROJECT-21350094
[Presentation] 光刺激により認識塩基が変化するシン配向型非天然核酸塩基の開発2012
- Author(s)
  森廣邦彦, 兒玉哲也, 小比賀聡
- Organizer
  日本化学会第92春季年会
- Place of Presentation
  慶応大学(横浜)
- Year and Date
  2012-03-25
- Data Source
  KAKENHI-PROJECT-21350094
[Presentation] Cleavage of Oligonucleotides Containing a P3'→N5' Phosphoramidate Linkage Triggered by Duplex Formation2011
- Author(s)
  K.R.Ito, T.Kodama, F.Makimura, N.Hosoki, T.Osaki, A.Orita, T.Imanishi, S.Obika.
- Organizer
  The 38th International Symposium on Nucleic Acid Chemistry (2011ISNAC)
- Place of Presentation
  北海道大学(札幌)
- Data Source
  KAKENHI-PROJECT-21350094
[Presentation] Cleavage of Oligonucleotides Containing a P3'→N5' Phosphoramidate Linkage Triggered by Duplex Formation2011
- Author(s)
  Kosuke. R. Ito, Tetsuya Kodama, Futaba Makimura, Noritsugu Hosoki, Tomohisa Osaki, Ayako Orita, Takeshi Imanishi, Satoshi Obika
- Organizer
  The 38th International Symposium on Nucleic Acid Chemistry(2011ISNAC)
- Place of Presentation
  北海道大学(札幌)
- Data Source
  KAKENHI-PROJECT-21350094
[Presentation] A new entry of thiol-containing nucleic acid monomer for conjugation chemistry2011
- Author(s)
  Tetsuya Kodama, Kazuto Mori, Takeshi Baba, Satoshi Obika
- Organizer
  6th Cambridge Symposium on Nucleic Acids Chemistry and Biology
- Place of Presentation
  Queens' College Cambridge, UK
- Data Source
  KAKENHI-PROJECT-21350094
[Presentation] Synthesis and Evaluation of External Stimuli-responsive Bridged Nucleic Acids2011
- Author(s)
  K.Morihiro, T.Kodama, S.Obika
- Organizer
  The 38th International Symposium on Nucleic Acid Chemistry (2011ISNAC)
- Place of Presentation
  北海道大学(札幌)
- Data Source
  KAKENHI-PROJECT-21350094
[Presentation] Synthesis and Evaluation of External Stimuli-responsive Bridged Nucleic Acids2011
- Author(s)
  Kunihiko Morihiro, Tetsuya Kodama, Satoshi Obika
- Organizer
  The 38th International Symposium on Nucleic Acid Chemistry(2011ISNAC)
- Place of Presentation
  北海道大学(札幌)
- Data Source
  KAKENHI-PROJECT-21350094
[Presentation] 機能性人工核酸の開発-新たな核酸医薬・診断薬創出に向けて-2010
- Author(s)
  小比賀聡
- Organizer
  日本化学会第90春季年会
- Place of Presentation
  大阪
- Year and Date
  2010-03-27
- Data Source
  KAKENHI-PROJECT-21350094
[Presentation] Synthesis and properties of 2', 4'-BNA with 8-aza-7-deazaguanine2010
- Author(s)
  Yumi Takegaki, Kunihiko Morihiro, Tetsuya Kodama, Moeka Nakatani and Satoshi Obika
- Organizer
  The International Chemical Congress of Pacific Basin Societies(PACIFICHEM 2010)
- Place of Presentation
  Honolulu, Hawaii(USA)
- Data Source
  KAKENHI-PROJECT-21350094
[Presentation] 機能性人工核酸の開発 -新たな核酸医薬・診断薬創出に向けて-2010
- Author(s)
  小比賀聡
- Organizer
  日本化学会第90春季年会
- Place of Presentation
  大阪
- Year and Date
  2010-03-27
- Data Source
  KAKENHI-PROJECT-20655038
[Presentation] Synthesis and properties of 2',4'-BNA with 8-aza-7-deazaguanine.2010
- Author(s)
  Satoshi Obika, 他4名
- Organizer
  The International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2010)
- Place of Presentation
  Honolulu, Hawaii (USA)
- Data Source
  KAKENHI-PROJECT-21350094
[Presentation] Synthesis of a novel trans-3',4'-BNA bearing a 3-oxa-4-azapentylene bridge2009
- Author(s)
  T. Kodama, K. Sugaya, T. Baba, T. Imanishi, S. Obika
- Organizer
  129^<th> Annual Meeting of the Japan Pharmaceutical Society
- Place of Presentation
  Kyoto
- Year and Date
  2009-03-26
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18550151
[Presentation] Effects of 2',4'-BNA^<NC> modification of triplex-forming oligonucleotides on triplex DNA formation2009
- Author(s)
  K. Sasaki, S. M. A. Rahman, T. Imanishi, S. Obika, H. Torigoe
- Organizer
  89^<th> Annual Meeting of the Chemical Society of Japan
- Place of Presentation
  Funabashi
- Year and Date
  2009-03-27
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18550151
[Presentation] Synthesis and properties of a novel nucleic acid analogue as a redox switch2009
- Author(s)
  T. Baba, T. Kodama, T. Imanishi, S. Obika
- Organizer
  129^<th> Annual Meeting of the Japan Pharmaceutical Society
- Place of Presentation
  Kyoto
- Year and Date
  2009-03-26
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18550151
[Presentation] Development of 5'-aminomethyl-type nucleic acid derivative for rapid gene detection2009
- Author(s)
  T. Tanaka, N. Hosoki A. Orita, T. Imanishi, S. Obika
- Organizer
  129^<th> Annual Meeting of the Japan Pharmaceutical Society
- Place of Presentation
  Kyoto
- Year and Date
  2009-03-26
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18550151
[Presentation] 機能性人工核酸の創製とその応用2009
- Author(s)
  小比賀聡
- Organizer
  生物医工学サロン第36回集会
- Place of Presentation
  大阪
- Year and Date
  2009-06-03
- Data Source
  KAKENHI-PROJECT-20655038
[Presentation] 核酸分子のキラリティー制御とその応用2009
- Author(s)
  小比賀聡
- Organizer
  Symposium on Molecular Chirality 2009
- Place of Presentation
  大阪
- Year and Date
  2009-05-12
- Data Source
  KAKENHI-PROJECT-20655038
[Presentation] Enzymatic incorporation of 2',4'-BNA nucleotides into 3'terminal of oligonucleotides and evaluation of nuclease resistance of the obtained modified oligonucleotides2009
- Author(s)
  N. Hagiwara, H. Takeshima, M. Kuwahara, H. Ozaki, H. Sawai, S. Obika, T. Imanishi
- Organizer
  89^<th> Annual Meeting of the Chemical Society of Japan
- Place of Presentation
  Funabashi
- Year and Date
  2009-03-27
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18550151
[Presentation] 機能性アンチセンス分子による核酸医薬の開発2009
- Author(s)
  小比賀聡
- Organizer
  第3回創薬とイメージングに関するワークショップ
- Place of Presentation
  大阪
- Year and Date
  2009-12-04
- Data Source
  KAKENHI-PROJECT-20655038
[Presentation] 機能性アンチセンス分子による核酸医薬の開発2009
- Author(s)
  小比賀聡
- Organizer
  第3回創薬とイメージングに関するワークショップ
- Place of Presentation
  大阪
- Year and Date
  2009-12-04
- Data Source
  KAKENHI-PROJECT-21350094
[Presentation] 高機能性人工核酸BNAの開発～次世代の核酸医薬・診断薬創出に向けて～2009
- Author(s)
  小比賀聡
- Organizer
  遺伝子・デリバリー研究会第9回シンポジウム
- Place of Presentation
  大阪
- Year and Date
  2009-07-10
- Data Source
  KAKENHI-PROJECT-20655038
[Presentation] RNA selective binding of a novel bridged nucleic acid bearing a urea structure2009
- Author(s)
  M. Nishida, T. Kodama, T. Baba, T. Imanishi, S. Obika
- Organizer
  129^<th> Annual Meeting of the Japan Pharmaceutical Society
- Place of Presentation
  Kyoto
- Year and Date
  2009-03-26
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18550151
[Presentation] 新たなポストゲノムテクノロジー素材としての架橋型人工核酸2009
- Author(s)
  小比賀聡
- Organizer
  第8回産学官連携推進会議
- Place of Presentation
  京都
- Year and Date
  2009-06-21
- Data Source
  KAKENHI-PROJECT-20655038
[Presentation] Development a novel fluorescent molecule bearing a 2,2'-bisbenzimidazole structure and its application to oligonucleotide labeling2008
- Author(s)
  K. Matsuyama, T. Watanabe, T. Kodama, S. Obika K. Miyashita, T. Imanishi
- Organizer
  3^<rd> Joint Symposium on Bio-related Chemistry
- Place of Presentation
  Yokohama
- Year and Date
  2008-09-18
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18550151
[Presentation] Development of a molecular probe for sequence-selective detection of 8-hydroxyguanine2008
- Author(s)
  T. Kodama, T. Miyoshi, S. Obika, T. Imanishi
- Organizer
  128^<th> Annual Meeting of the Pharmaceutical Society Japan
- Place of Presentation
  Yokohama
- Year and Date
  2008-03-25
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18550151
[Presentation] Synthesis and properties of a novel bridged nucleic acid bearing a carbamate structure2008
- Author(s)
  M. Nishida, T. Kodama, T. Baba, S. Obika, T. Imanishi
- Organizer
  34^<th> Symposium on Progress in Organic Reactions and Syntheses
- Place of Presentation
  Kyoto
- Year and Date
  2008-11-04
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18550151
[Presentation] Regulation of gene expression by BNA modified siRNA2008
- Author(s)
  H. Satoh, N. Tsuda, S. Haitani, A. Matsumoto, T. Imanishi, S. Obika
- Organizer
  Symposium on Biofunctional Chemistry of the Chemical Society of Japan, Forum for Young Scientist
- Place of Presentation
  Yokohama
- Year and Date
  2008-09-17
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18550151
[Presentation] Post elongation modification of oligonucleotides using click chemistry for discovery of a functional nucleobase2008
- Author(s)
  M. Nakahara, T. Kuboyama, A. Izawa, T. Imanishi, S. Obika
- Organizer
  Symposium on Biofunctional Chemistry of the Chemical Society of Japan, Forum for Young Scientist
- Place of Presentation
  Yokohama
- Year and Date
  2008-09-17
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18550151
[Presentation] Synthesis and properties of novel nucleic acid analogues bearing a P3'->N5' phosphoramidate linkage2008
- Author(s)
  N. Hosoki, T. Osakai, A. Orita, S. Obika, T. Imanishi
- Organizer
  128^<th> Annual Meeting of the Pharmaceutical Society Japan
- Place of Presentation
  Yokohama
- Year and Date
  2008-03-25
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18550151
[Presentation] 光開裂型人工核酸2', 4'-BNA^<COC>アナログの合成2008
- Author(s)
  森廣邦彦(小比賀聡)
- Organizer
  第5 8回日本薬学会近畿支部大会
- Place of Presentation
  兵庫
- Year and Date
  2008-10-25
- Data Source
  KAKENHI-PROJECT-20655038
[Presentation] Detection of protein-aptamer interactions using a BNA probe and single molecule detection system MF202008
- Author(s)
  Y. Kaneko, T. Imanishi, S. Obika
- Organizer
  18^<th> Antisense Symposium
- Place of Presentation
  Gifu
- Year and Date
  2008-11-18
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18550151
[Presentation] Promotion of triplex formation by 2'-O,4'-C-aminomethylene bridged nucleic acid (2',4'-BNANC )modificaion2008
- Author(s)
  K. Sasaki, S. M. A. Rahman, S. Obika, T. Imanishi, H. Torigoe
- Organizer
  Joint Symposium of 18^<th> International Roundtable on Nucleosides, Nucleotides and Nucleic Acids and 35^<th> International Symposium on Nucleic Acids Chemistry
- Place of Presentation
  Kyoto
- Year and Date
  2008-09-11
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18550151
[Presentation] Post elongation modification of oligonucleotides using click chemistry for discovery of a functional nucleobase2008
- Author(s)
  M. Nakahara, T. Kuboyama, A. Izawa, T. Imanishi, S. Obika
- Organizer
  3^<rd> Joint Symposium on Bio-related Chemistry
- Place of Presentation
  Yokohama
- Year and Date
  2008-09-18
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18550151
[Presentation] カルバマート骨格を有する新規架橋型人工核酸の合成とその評価2008
- Author(s)
  西田勝(小比賀聡)
- Organizer
  第3 4回反応と合成の進歩シンポジウム
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-20655038
[Presentation] Application of bridged nucleic acids to siRNA2008
- Author(s)
  H. Satoh, K. Narukawa, T. Imanishi, S. Obika
- Organizer
  8^<th> Summer Seminar of the Society for Gene and Delivery
- Place of Presentation
  Kobe
- Year and Date
  2008-08-08
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18550151
[Presentation] BNA修飾三重鎖形成オリゴヌクレオチドによる細胞内での遺伝子発現制御2008
- Author(s)
  小比賀聡
- Organizer
  日本ケミカルバイオロジー研究会第3回年会
- Place of Presentation
  東京
- Year and Date
  2008-05-20
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18550151
[Presentation] Molecular imaging for drug discovery based on chemical biology of nucleic acids, peptides and sugars2008
- Author(s)
  S. Obika
- Organizer
  Symposium on Molecular Imaging
- Place of Presentation
  Kobe
- Year and Date
  2008-12-14
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18550151
[Presentation] Synthesis and properties of bridged nucleic acids bearing a urea skeleton2008
- Author(s)
  M. Nishida, T. Kodama, T. Baba, T. Imanishi, S. Obika
- Organizer
  18^<th> Antisense Symposium
- Place of Presentation
  Gifu
- Year and Date
  2008-11-18
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18550151
[Presentation] Promotion of acid-mediated P-N bond clevage of 5'-amino-2', 4'-BNA oligonucleotides by triplex formation : effect of neighboring residues2008
- Author(s)
  S. Obika
- Organizer
  XIV th Symposium on Chemistry of Nucleic Acid Components
- Place of Presentation
  チェコ共和国
- Year and Date
  2008-06-08
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18550151
[Presentation] Design and chemical synthesis of 2',4'-BNA probe for 7,8-dihydro-8-oxoguanine containing double stranded DNA2008
- Author(s)
  T. Miyoshi, T. Kodama, S. Obika, T. Imanishi
- Organizer
  Joint Symposium of 18^<th> International Roundtable on Nucleosides, Nucleotides and Nucleic Acids and 35^<th> International Symposium on Nucleic Acids Chemistry
- Place of Presentation
  Kyoto
- Year and Date
  2008-09-11
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18550151
[Presentation] Regulation of gene expression by BNA modified siRNA2008
- Author(s)
  H. Satoh, N. Tsuda, S. Haitani, A. Matsumoto, T. Imanishi, S. Obika
- Organizer
  3^<rd> Joint Symposium on Bio-related Chemistry
- Place of Presentation
  Yokohama
- Year and Date
  2008-09-18
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18550151
[Presentation] Application of bridged nucleic acids to siRNA2008
- Author(s)
  H. Satoh, N. Tsuda, K. Narukawa, T. Imanishi, S. Obika
- Organizer
  18^<th> Antisense Symposium
- Place of Presentation
  Gifu
- Year and Date
  2008-11-18
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18550151
[Presentation] Regulation of gene expression in a living cell by BNA modified triplex-forming oligonucleotides2008
- Author(s)
  S. Obika, S. Haitani, A. Itoh, N. Tsuda, H. Inohara, A. Fujisaka, A. Matsumoto, T. Imanishi
- Organizer
  XlVth Symposium on Chemistry of Nucleic Acid Components
- Place of Presentation
  Cesky Krumlov, Czech Republic
- Year and Date
  2008-06-08
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18550151
[Presentation] Stabilization of triplex DNA under physiological conditions by 3'-amino-2',4'-BNA modification of triplex-forming oligonucleotides2008
- Author(s)
  K. Sasaki, S. Obika, T. Imanishi, H. Torigoe
- Organizer
  3^<rd> Joint Symposium on Bio-related Chemistry
- Place of Presentation
  Yokohama
- Year and Date
  2008-09-18
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18550151
[Presentation] Development of an artificial triplex-forming oligonucleotide for sequence-selective recognition of 8-OxoG (2)2008
- Author(s)
  T. Kodama, T. Miyoshi, S. Obika, T. Imanishi
- Organizer
  58th Annual Meeting of the Japan Pharmaceutical Society, Kinki Brunch
- Place of Presentation
  Kobe
- Year and Date
  2008-10-25
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18550151
[Presentation] Incorporation of 2',4'-bridged nucleotides into oligonucleotides by using terminal deoxynucleotidyl transferase2008
- Author(s)
  H. Takeshima, M. Kuwahara, S. Obika, H. Ozaki, H. Sawai, T. Imanishi
- Organizer
  2nd Annual Meeting of the Chemical Society of Japan, Kanto Brunch
- Place of Presentation
  Gunma
- Year and Date
  2008-09-18
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18550151
[Presentation] Synthesis of a novel photo-labile 2',4'-BNA2008
- Author(s)
  K. Morihiro, M. Nishida, T. Imanishi, S. Obika
- Organizer
  58th Annual Meeting of the Japan Pharmaceutical Society, Kinki Brunch
- Place of Presentation
  Kobe
- Year and Date
  2008-10-25
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18550151
[Presentation] Synthesis of azinomycin derivatives having a 3,4-epoxypiperidine skeleton2008
- Author(s)
  Y. Kawada, T. Yamaguchi, K. Miyashita, S. Obika, T. Imanishi
- Organizer
  94th Symposium on Organic Synthesis
- Place of Presentation
  Tokyo
- Year and Date
  2008-11-08
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18550151
[Presentation] Biologically active 2-5A analogs containing 3'-O,4'-C-propylene adenosine as potent Rnase L agonists2008
- Author(s)
  M. Koizumi, K. Morita, S. Obika, T. Imanishi, Y. Kitade
- Organizer
  Joint Symposium of 18^<th> International Roundtable on Nucleosides, Nucleotides and Nucleic Acids and 35^<th> International Symposium on Nucleic Acids Chemistry
- Place of Presentation
  Kyoto
- Year and Date
  2008-09-11
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18550151
[Presentation] Development of bridged nucleic acids for gene regulation and analysis2008
- Author(s)
  S. Obika
- Organizer
  128^<th> Annual Meeting of the Pharmaceutical Society Japan
- Place of Presentation
  Yokohama
- Year and Date
  2008-03-25
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18550151
[Presentation] Detection of protein-aptamer interactions using a BNA probe and single molecule detection system MF202008
- Author(s)
  Y. Kaneko, T. Imanishi, S. Obika
- Organizer
  31^<st> Annual Meeting of the Molecular Biology Society of Japan and 81^<st> Annual Meeting of the Japan Biochemical Society
- Place of Presentation
  Yokohama
- Year and Date
  2008-12-10
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18550151
[Presentation] Development of an artificial triplex-forming oligonucleotide for sequence-selective recognition of 8-OxoG (1)2008
- Author(s)
  T. Miyoshi, T. Kodama, S. Obika T. Imanishi
- Organizer
  58th Annual Meeting of the Japan Pharmaceutical Society, Kinki Brunch
- Place of Presentation
  Kobe
- Year and Date
  2008-10-25
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18550151
[Presentation] Synthesis and properties of novel DNA alkylating agents having a 3,4-epoxypiperidine structure2008
- Author(s)
  Y. Kawada, T. Yamaguchi, K. Miyashita, S. Obika, T. Imanishi
- Organizer
  27^<th> Symposium on Medicinal Chemistry
- Place of Presentation
  Osaka
- Year and Date
  2008-11-26
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18550151
[Presentation] Promotion of pyrimidine motif triplex formation at physiological pH by 3'-amino-2'-O,4'-C-methylene bridged nucleic acid modification2008
- Author(s)
  K. Sasaki, S. Obika, T. Imanishi, H. Torigoe
- Organizer
  46^<th> Annual Meeting of the Biophysical Society of Japan
- Place of Presentation
  Hakata
- Year and Date
  2008-12-04
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18550151
[Presentation] Development a novel fluorescent molecule bearing a 2,2'-bisbenzimidazole structure and its application to oligonucleotide labeling2008
- Author(s)
  K. Matsuyama, T. Watanabe, T. Kodama, S. Obika K. Miyashita, T. Imanishi
- Organizer
  Symposium on Biofunctional Chemistry of the Chemical Society of Japan, Forum for Young Scientist
- Place of Presentation
  Yokohama
- Year and Date
  2008-09-17
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18550151
[Presentation] Synthesis of azinomycin derivatives bearing 3,4-epoxypiperidine2008
- Author(s)
  Y. Kawada, T. Yamaguchi, K. Miyashita, S. Obika, T. Imanishi
- Organizer
  38^<th> Congress of Heterocyclic Chemistry
- Place of Presentation
  Fukuyama
- Year and Date
  2008-11-22
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18550151
[Presentation] Rapid DNA detection triggered by triplex DNA formation2008
- Author(s)
  Y. Negoro, M. Tomizu, A. Orita, S. Obika, T. Imanishi
- Organizer
  128^<th> Annual Meeting of the Pharmaceutical Society Japan
- Place of Presentation
  Yokohama
- Year and Date
  2008-03-25
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18550151
[Presentation] 遺伝子の発現制御と解析に向けた機能性人工核酸BNAの開発2008
- Author(s)
  小比賀聡
- Organizer
  日本薬学会第128回年会
- Place of Presentation
  横浜
- Year and Date
  2008-03-25
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18550151
[Presentation] Regulation of gene expression in a living cell by BNA modified triplex-forming oligonucleotides2008
- Author(s)
  S. Obika, S. Haitani, A. Itoh, N. Tsuda, H. Inohara, A. Fujisaka, A. Matsumoto, T. Imanishi
- Organizer
  3^<rd> Annual Meeting of the Japanese Society for Chemical Biology
- Place of Presentation
  Tokyo
- Year and Date
  2008-05-20
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18550151
[Presentation] Modification of siRNA with bridged nucleic acids BNAs2008
- Author(s)
  H. Satoh, N. Tsuda, K. Narukawa, T. Imanishi, S. Obika
- Organizer
  31^<st> Annual Meeting of the Molecular Biology Society of Japan and 81^<st> Annual Meeting of the Japan Biochemical Society
- Place of Presentation
  Yokohama
- Year and Date
  2008-12-10
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18550151
[Presentation] Molecular imaging for drug discovery based on chemical biology of nucleic acids, peptides and sugars2008
- Author(s)
  小比賀聡
- Organizer
  分子イメージング研究シンポジウム
- Place of Presentation
  神戸
- Year and Date
  2008-12-14
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18550151
[Presentation] Regulation of IL-2Ra gene expression by a triplexforming oligonucleotide containing BNA2007
- Author(s)
  S. Haitani, A. Itoh, N. Tsuda, H. Inohara, A. Fujisaka, A. Matsumoto, S. Obika, T. Imanishi
- Organizer
  17^<th> Antisense Symposium
- Place of Presentation
  Kanazawa
- Year and Date
  2007-12-03
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18550151
[Presentation] Polymerisation of a DNA strand using oligo-DNA template with modified bases, sugar and phosphates2007
- Author(s)
  J. Nagashima, S. Minezaki, S. Obika, T. Imanishi, M. Kuwahara, H. Sawai
- Organizer
  5^<th> International Symposium on Nucleic Acids Chemistry
- Place of Presentation
  Tokyo
- Year and Date
  2007-11-19
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18550151
[Presentation] Inhibition of bcl-xl expression with antisense oligonucleotides containing various bridged nucleic acids (BNAs)2007
- Author(s)
  S. Roongjang, K. Takahashi, S. Obika, T. Imanishi
- Organizer
  5^<th> International Symposium on Nucleic Acids Chemistry
- Place of Presentation
  Tokyo
- Year and Date
  2007-11-19
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18550151
[Presentation] Rapid and convenient SNP analysis based on triplex formation2007
- Author(s)
  S. Obika, M. Tomizu, Y. Negoro A. Orita, T. Osaki, T. Imanishi
- Organizer
  2nd Annual Meeting of the Japanese Society for Chemical Biology
- Place of Presentation
  Kyoto
- Year and Date
  2007-05-09
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18550151
[Presentation] Regulation of IL-2Ra gene expression by a triplexforming oligonucleotide containing BNA2007
- Author(s)
  S. Haitani, A. Itoh, N. Tsuda, H. Inohara, A. Fujisaka, A. Matsumoto, S. Obika, T. Imanishi
- Organizer
  30^<th> Annual Meeting of the Molecular Biology Society of Japan and 80th Annual Meeting of the Japan Biochemical Society
- Place of Presentation
  Yokohama
- Year and Date
  2007-12-11
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18550151
[Presentation] 三重鎖核酸形成を基盤とする革新的DNA分析2007
- Author(s)
  小比賀聡
- Organizer
  イノベーションセミナー
- Place of Presentation
  大阪
- Year and Date
  2007-10-22
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18550151
[Presentation] Synthesis and properties of a 2'-deoxy-type trans-3',4'-BNA having an S-type sugar conformation2007
- Author(s)
  K. Sugaya, Y. Harada, Y. Mitsuoka, T. Osaki, S. Obika, T. Kodama, T. Imanishi
- Organizer
  27^<th> Organic Synthesis Seminar for Young Scientist
- Place of Presentation
  Kyoto
- Year and Date
  2007-11-15
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18550151
[Presentation] 三重鎖核酸形成を基盤とする革新的BNA分析2007
- Author(s)
  小比賀聡
- Organizer
  日本薬学会第127回年会
- Place of Presentation
  富山
- Year and Date
  2007-03-28
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18550151
[Presentation] 三重鎖形成核酸を利用した迅速・簡便なSNP検出2007
- Author(s)
  小比賀聡
- Organizer
  日本ケミカルバイオロジー研究会第2回年会
- Place of Presentation
  京都
- Year and Date
  2007-05-09
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18550151
[Presentation] Innovative DNA analysis based on triplex formation2007
- Author(s)
  S. Obika, M. Tomizu, Y. Negoro, N. Hosoki, A. Orita, T. Osaki, T. Imanishi
- Organizer
  Osaka University Innovation Seminar
- Place of Presentation
  Osaka
- Year and Date
  2007-10-22
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18550151
[Presentation] Antisense effect of some BNA oligonucleotides targeting anti-apoptotic gene bcl-xl2007
- Author(s)
  S. Roongjang, K. Takahashi, S. Obika, T. Imanishi
- Organizer
  2nd Annual Meeting of the Japanese Society for Chemical Biology
- Place of Presentation
  Kyoto
- Year and Date
  2007-05-09
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18550151
[Presentation] Innovative DNA analysis based on triplex formation2007
- Author(s)
  S. Obika, M. Tomizu, Y. Negoro, T. Imanishi
- Organizer
  127^<th> Annual Meeting of the Pharmaceutical Society Japan
- Place of Presentation
  Toyama
- Year and Date
  2007-03-28
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18550151
[Presentation] Synthesis and chemical properties of a novel 2',4'-bridged nucleic acid analogue with a seven-membered cyclic carbamate structure2007
- Author(s)
  T. Kodama, C. Matsuo, H. Ori, S. Obika, K. Miyashita, T. Imanishi
- Organizer
  5^<th> International Symposium on Nucleic Acids Chemistry
- Place of Presentation
  Tokyo
- Year and Date
  2007-11-19
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18550151
[Presentation] Synthesis and properties of a 2'-deoxy analogue of trans-3',4'-BNAhaving an S-type sugar conformation2007
- Author(s)
  K. Sugaya, Y. Harada, Y. Mitsuoka, T. Osaki, S. Obika, T. Kodama, T. Imanishi
- Organizer
  5^<th> International Symposium on Nucleic Acids Chemistry
- Place of Presentation
  Tokyo
- Year and Date
  2007-11-19
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18550151
[Presentation] Synthesis of a novel 2',4'-BNA bearing seven-membered carbamate structure2007
- Author(s)
  M. Nishida, T. Kodama, S. Obika, T. Imanishi
- Organizer
  127^<th> Annual Meeting of the Pharmaceutical Society Japan
- Place of Presentation
  Toyama
- Year and Date
  2007-03-28
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18550151
[Presentation] Synthesis of a novel bridged nucleic acid, trans-3',4'-BNA2007
- Author(s)
  K. Sugaya, Y. Harada, Y. Mitsuoka, T. Kodama, S. Obika, T. Imanishi
- Organizer
  57^<th> Annual Meeting of the Japan Pharmaceutical Society, Kinki Brunch
- Place of Presentation
  Osaka
- Year and Date
  2007-10-27
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18550151
[Presentation] 迅速簡便な遺伝子検出を目指した機能性人工核酸5'-amino-BNA類の開発2007
- Author(s)
  小比賀聡
- Organizer
  第33回反応と合成の進歩シンポジウム
- Place of Presentation
  長崎
- Year and Date
  2007-11-04
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18550151
[Presentation] Development of 5'-amino-2',4'-BNAs for rapid and convenient gene detection2007
- Author(s)
  S. Obika, M. Tomizu, Y. Negoro, N. Hosoki, A. Orita, T. Osaki, T. Imanishi
- Organizer
  33^<rd> Symposium on Progress in Organic Reactions and Syntheses
- Place of Presentation
  Nagasaki
- Year and Date
  2007-11-04
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18550151
[Presentation] Synthesis and evaluation of a novel 2',5'-bridged nucleic acid with sugar conformation fixed to S-type by N-0 linkage2007
- Author(s)
  M. Nishida, T. Kodama, S. Obika, T. Imanishi
- Organizer
  5^<th> International Symposium on Nucleic Acids Chemistry
- Place of Presentation
  Tokyo
- Year and Date
  2007-11-19
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18550151
[Presentation] Synthesis and properties of a novel 2',5'-linked nucleic acid bearing a locked S-type conformation with an N-0 linkage2007
- Author(s)
  T. Kodama, C. Matsuo, H. Ori, S. Obika, K. Miyashita, T. Imanishi
- Organizer
  57^<th> Annual Meeting of the Japan Pharmaceutical Society, Kinki Brunch
- Place of Presentation
  Osaka
- Year and Date
  2007-10-27
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18550151
[Presentation] Antigene Block Strategy2006
- Author(s)
  A. Itoh, N. Tsuda, S. Haitani, A. Matsumoto, T. Uneda, A. Tanabe, S. Obika, T. Imanishi
- Organizer
  1^<st> Annual Meeting of the Japanese Society for Chemical Biology
- Place of Presentation
  Tokyo
- Year and Date
  2006-05-08
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18550151
[Presentation] Regulation of IL-2Ra gene expression by antigene block strategy2006
- Author(s)
  Haitani, A. Itoh, N. Tsuda, A. Matsumoto, T. Uneda, A. Tanabe, S. Obika, T. Imanishi
- Organizer
  16^<th> Antisense Symposium
- Place of Presentation
  Kyoto
- Year and Date
  2006-11-27
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18550151
[Presentation] Regulation of bcl-xl gene expression by 2',4'-BNA antisense oligonucleotides2006
- Author(s)
  K. Takahashi, S. Roongjang, M. Park, S. Obika, T. Imanishi
- Organizer
  56th Annual Meeting of the Japanese Pharmaceutical Society, Kinki Brunch
- Place of Presentation
  Kyoto
- Year and Date
  2006-10-28
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18550151
[Presentation] Syntheses and properties of trans-3'-4'-bridged nucleic acids2006
- Author(s)
  T. Osaki, S. Obika, Y. Harada, Y. Mitsuoka, K. Sugaya, M. Sekiguchi, S. Roongjang, T. Imanishi
- Organizer
  X VII International Roundtable on Nucleosides, Nucleotides and Nucleic Acids
- Place of Presentation
  Bern
- Year and Date
  2006-09-03
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18550151
[Presentation] Regulation of IL-2Ra gene expression by antigene block strategy2006
- Author(s)
  A. Itoh, N. Tsuda, S. Haitani, A. Matsumoto, S. Obika, T. Imanishi
- Organizer
  56th Annual Meeting of the Japanese Pharmaceutical Society, Kinki Brunch
- Place of Presentation
  Kyoto
- Year and Date
  2006-10-28
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18550151
[Presentation] Acid-mediated cleavage of oligonucleotides P3'→N5' phosphoramidates triggered by sequence specific triplex formation2006
- Author(s)
  S. Obika, M. Tomizu, Y. Negoro, T. Osaki, A. Orita, Y. Ueyama, O. Nakagawa, T. Imanishi
- Organizer
  X VII International Roundtable on Nucleosides, Nucleotides and Nucleic Acids
- Place of Presentation
  Bern
- Year and Date
  2006-09-03
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18550151
[Presentation] Acid-mediated cleavage of oligonucleotides P3'→N5' phosphoramidates triggered by sequence specific triplex formation2006
- Author(s)
  S. Obika
- Organizer
  XVII International Roundtable on Nucleosides, Nucleotides and Nucleic Acids
- Place of Presentation
  スイス, ベルン
- Year and Date
  2006-09-03
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18550151
[Presentation] Antisense Activity of 2',4'-BNA Targetd to bcl-xL Gene in HepG2 Cell2006
- Author(s)
  S. Roongjang, K. Takahashi, M. Park, S. Obika, T. Imanishi
- Organizer
  33^<rd> Synposium on Nucleic Acids Chemistry
- Place of Presentation
  Osaka
- Year and Date
  2006-11-20
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18550151
[Presentation] 2',4' BNA^<NC> : A novel bridged nucleic acid analogue with exellent hybridzing and nuclease resistance profiles2006
- Author(s)
  S. M. A. Rahman, S. Seki, K. Utsuki, S. Obika, K. Kazuyuki, T. Imanishi
- Organizer
  X VII International Roundtable on Nucleosides, Nucleotides and Nucleic Acids
- Place of Presentation
  Bern
- Year and Date
  2006-09-03
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18550151
[Presentation] Regulation of bcl-xl gene expression by 2',4'-BNA antisense oligonucleotides and induction of apoptosis2006
- Author(s)
  K. Takahashi, S. Roongjang, A. Matsumoto, M. Park, S. Obika, T. Imanishi
- Organizer
  16^<th> Antisense Symposium
- Place of Presentation
  Kyoto
- Year and Date
  2006-11-27
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18550151
[Presentation] Innovative DNA analysis based on triplex formation2006
- Author(s)
  S. Obika, M. Tomizu, Y. Negoro, T. Osaki, A. Orita, Y. Ueyama, T. Imanishi
- Organizer
  Osaka University Innovation Seminar
- Place of Presentation
  Osaka
- Year and Date
  2006-10-23
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18550151
[Presentation] 三重鎖核酸形成を基盤とする革新的BNA分析2006
- Author(s)
  小比賀聡
- Organizer
  大阪大学イノベーションセミナー
- Place of Presentation
  大阪
- Year and Date
  2006-10-23
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18550151
[Presentation] Synthesisi of 2',4'-BNA^<coc> bearing an adenine nucleobase2006
- Author(s)
  Y. Mitsuoka, S. Obika, T. Imanishi
- Organizer
  56th Annual Meeting of the Japanese Pharmaceutical Society, Kinki Brunch
- Place of Presentation
  Kyoto
- Year and Date
  2006-10-28
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18550151
[Presentation] 三重鎖核酸形成を基盤とする革新的DNA分析2006
- Author(s)
  小比賀聡
- Organizer
  日本ケミカルバイオロジー研究会第1回年会
- Place of Presentation
  東京
- Year and Date
  2006-05-08
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18550151
[Presentation] High-affinity RNA Mimicking Binding of 2',4'-BNA^<NC>Towards Complementary Strands : A Comparative Study with 2',4'-BNA/LNA2006
- Author(s)
  S. M. A. Rahman, S. Seki, K. Utsuki, S. Obika, K. Miyashita, T. Imanishi
- Organizer
  33^<rd> Synposium on Nucleic Acids Chemistry
- Place of Presentation
  Osaka
- Year and Date
  2006-11-20
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18550151
[Presentation] Synthesis of 2',4'-BNA^<coc> Bearing a Purine Nucleobase2006
- Author(s)
  Y. Mitsuoka, R. Ohnishi, Y. Hari, S. Obika, T. Imanishi
- Organizer
  33^<rd> Synposium on Nucleic Acids Chemistry
- Place of Presentation
  Osaka
- Year and Date
  2006-11-20
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18550151
[Presentation] Rational combination of stabilizing strategies to achieve synergistic stabilization of nucleic acid assembly2006
- Author(s)
  T. Katayama, A. Maruyama, S. Obika, T. Imanishi, H. Torigoe
- Organizer
  5^<th> East Asian Biophysics Symposium and 44th Annual Meeting of the Biophysical Society of Japan
- Place of Presentation
  Okinawa
- Year and Date
  2006-11-14
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18550151
[Presentation] Innovative DNA analysis based on triplex formation2006
- Author(s)
  S. Obika, M. Tomizu, Y. Negoro, T. Imanishi
- Organizer
  1^<st> Annual Meeting of the Japanese Society for Chemical Biology
- Place of Presentation
  Tokyo
- Year and Date
  2006-05-08
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18550151
[Presentation] 2',4'-BNAを搭載した高活性なApolipoprotein C-III標的型アンチセンス核酸の開発
- Author(s)
  和田郁人、山本剛史、和田俊輔、安原秀典、小比賀聡、斯波真理子
- Organizer
  遺伝子・デリバリー研究会第13回シンポジウム
- Place of Presentation
  帝京大学（千葉）
- Data Source
  KAKENHI-PROJECT-24249007
[Presentation] セレノメチレン架橋型人工核酸の開発と酸化還元スイッチへの応用
- Author(s)
  森廣邦彦，兒玉哲也，肯特夫，百相義大，Veedu Rakesh.N，小比賀聡
- Organizer
  日本薬学会　第133年会
- Place of Presentation
  神奈川県横浜市
- Data Source
  KAKENHI-PROJECT-24249007
[Presentation] 配列モチーフを用いたアンチセンス効果予測モデルの構築
- Author(s)
  木谷真子、川下理日人、山本剛史、山下真季、岡本晃典、高木達也、小比賀聡
- Organizer
  第16回日本RNA学会
- Place of Presentation
  名古屋
- Year and Date
  2014-07-23 – 2014-07-25
- Data Source
  KAKENHI-PROJECT-24249007
[Presentation] Synthesis and properties of oligonucleotides containing 2’,4’-BNA/LNA-deazapurine analogues.
- Author(s)
  Hara Takashi, Kodama Tetsuya, Takegaki Yumi, Morihiro Kunihiko, Ito Kousuke R, Obika Satoshi
- Organizer
  10th Annual Meeting of the Oligonucleotide Therapeutics Society
- Place of Presentation
  San Diego, USA
- Year and Date
  2014-10-12 – 2014-10-14
- Data Source
  KAKENHI-PROJECT-24249007
[Presentation] Synthesis and Properties of Heterocycle-Bridged Nucleic Acids
- Author(s)
  Yasunori Mitsuoka, Akira Kugimiya, Aiko Yahara, and Satoshi Obika
- Organizer
  XXI ROUND TABLE ON NUCLEOSIDES, NUCLEOTIDES AND NUCLEIC ACIDS (IRT2014)
- Place of Presentation
  Poznan, Poland
- Year and Date
  2014-08-24 – 2014-08-28
- Data Source
  KAKENHI-PROJECT-24249007
[Presentation] 架橋型シクロヘキセニル核酸の機能性評価及び構造解析
- Author(s)
  百相義大、武田修一、松本友治、廣明秀一、小比賀聡、兒玉哲也
- Organizer
  第135回日本薬学会年会
- Place of Presentation
  神戸
- Year and Date
  2015-03-26 – 2015-03-28
- Data Source
  KAKENHI-PROJECT-24249007
[Presentation] 新規架橋型人工核酸の合成と機能評価;グアニジノ基による架橋部へのカチオン導入の効果
- Author(s)
  壽悠太郎、張功幸、Shrestha Ajaya Ram、小比賀聡
- Organizer
  アンチセンス・遺伝子・デリバリーシンポジウム2012
- Place of Presentation
  宮城県仙台市
- Data Source
  KAKENHI-PROJECT-24249007
[Presentation] 架橋型シクロヘキセニル核酸の構造解析及び機能性評価
- Author(s)
  百相義大、武田修一、松本友治、廣明秀一、小比賀聡、兒玉哲也
- Organizer
  アンチセンス・遺伝子・デリバリーシンポジウム2014
- Place of Presentation
  東京
- Year and Date
  2014-09-08 – 2014-09-09
- Data Source
  KAKENHI-PROJECT-24249007
[Presentation] チミン塩基をもつセレノメチレン架橋型人工核酸の合成と基本的性質
- Author(s)
  兒玉哲也，森廣邦彦，肯特夫，百相義大，VeeduR.N，小比賀聡
- Organizer
  アンチセンス・遺伝子・デリバリーシンポジウム 2012
- Place of Presentation
  宮城県仙台市
- Data Source
  KAKENHI-PROJECT-24249007
[Presentation] 舟型ピラノース核酸類の合成とその標的結合能
- Author(s)
  森和土、兒玉哲也、小比賀聡
- Organizer
  第39回反応と合成の進歩シンポジウム
- Place of Presentation
  九州大学（福岡）
- Data Source
  KAKENHI-PROJECT-24249007

1. IMANISHI Takeshi (40028866)

# of Collaborated Projects: 8 results

# of Collaborated Products: 0 results
2. Mori Masaki (70190999)

# of Collaborated Projects: 4 results

# of Collaborated Products: 2 results
3. KONNO Masamitsu (80618207)

# of Collaborated Projects: 4 results

# of Collaborated Products: 2 results
4. Kawamoto Koichi (30432470)

# of Collaborated Projects: 4 results

# of Collaborated Products: 2 results
5. ISHII Hideshi (10280736)

# of Collaborated Projects: 4 results

# of Collaborated Products: 2 results
6. KODAMA Tetsuya (00432443)

# of Collaborated Projects: 3 results

# of Collaborated Products: 36 results
7. Nishida Naohiro (50588118)

# of Collaborated Projects: 3 results

# of Collaborated Products: 2 results
8. Nishiyama Nobuhiro (10372385)

# of Collaborated Projects: 3 results

# of Collaborated Products: 1 results
9. KANDA Mitsuro (00644668)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
10. 小関準 (20616669)

# of Collaborated Projects: 3 results

# of Collaborated Products: 2 results
11. 笠原勇矢 (10740673)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
12. 清水大 (50723037)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
13. 田中千恵 (50589786)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
14. DOI Takefumi (00211409)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
15. 小寺泰弘 (10345879)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
16. NAKA Hiromi (10453119)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. TACHIBANA Keisuke (30432446)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. IHARA Toshihiro (40253489)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. SAKURAI Fuminori (70370939)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. TAKAGI Tatsuya (80144517)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
21. MORIHIRO Kunihiko (70713890)

# of Collaborated Projects: 1 results

# of Collaborated Products: 10 results
22. KAWASHITA Norihito (00423111)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
23. Kamei Motohiro (40281125)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. SUZUKI MIHOKO (40611166)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. MATSUMURA NAGAKAZU (40611174)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. TSUJIKAWA MOTOKAZU (70419472)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
27. GOMI FUMI (80335364)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
28. SAKAGUCHI HIROKAZU (80379172)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
29. YAMAMOTO Tsuyoshi (80636994)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
30. OKADA Yoshiaki (50444500)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
31. MUKAI Yohei (60444501)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
32. MIYASHITA Kazuyuki (10166168)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
33. Kuwahara Masayasu (40334130)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
34. Horie Sachiko (90451640)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
35. SATO YASUFUMI (50178779)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
36. Tozuka Zenzaburo (50624748)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
37. Matsui Hidetoshi (90633305)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
38. Saito Toshiyuki (90205667)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
39. 土岐祐一郎 (20291445)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
40. 三森功士 (50322748)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
41. 永野浩昭 (10294050)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
42. 中西香企 (10836183)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
43. MIZUGUCHI Hiroyuki

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
44. TACHIBANA Masashi

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
45. KATAYAMA Kazufumi

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
46. GOTO Hitoshi

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
47. NANJO Yuki

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
48. TANINO Fumihito

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
49. 張功幸

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

OBIKA SATOSHI 小比賀 聡

OBIKA Satoshi 小比賀 聡

小比賀 聡 オビカ サトシ

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The identification of long-noncoding RNAs associated with the formation of atherosclerotic plaques and their therapeutic manipulation strategyPrincipal Investigator

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Development of platform technologies for antisense oligonucleotide-based therapeutics by a combination of nucleic acids chemistry and information sciencesPrincipal Investigator

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Regulation of RNA Splicing by BNA Antisense OligonucleotidesPrincipal Investigator

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OBIKA SATOSHI 小比賀聡

OBIKA Satoshi 小比賀聡

小比賀聡オビカサトシ