MUKAI HIDEYUKI 向井秀幸

… Alternative Names

Researcher Number	80252758
Other IDs
External Links
Affiliation (Current)	2021: 神戸大学, バイオシグナル総合研究センター, 研究員
Affiliation (based on the past Project Information) *help	2017 – 2019: 神戸大学, バイオシグナル総合研究センター, 准教授 2017: 神戸大学, 医学系研究科, 准教授 2010 – 2015: 神戸大学, バイオシグナル研究センター, 准教授 2014: 神戸大学, 大学院医学研究科, 准教授 2012: 神戸大学, 医学研究科, 准教授 … More
Review Section/Research Field	Principal Investigator Structural biochemistry / Functional biochemistry / Biological Sciences / Cell biology / Living organism molecular science / Pathological medical chemistry / Tumor biology Except Principal Investigator Neurology / Neurophysiology and muscle physiology / General pharmacology … More
Keywords	Principal Investigator PKN / protein kinase / Rho / PKN1 / RhoA / RhoB / FRET / kinase activity / CFP / YFP … More Except Principal Investigator PKN / タウ蛋白 / 蛋白リン酸化酵素 / 蛋白脱リン酸化酵素 / 認知症 / 細胞内シグナル伝達 / 蛋白質リン酸化酵素 / Signal transduction / 細胞内情報伝達機構 / プロテインキナーゼC / CG-NAP / ストレス / PKN1 / 神経細胞変性 / protein kinase N / 代謝型グルタミン酸受容体 / グルタミン酸トランスポーター / 海馬歯状回 / アルツハイマー病 / Alzheimer disease / Tau / Protein kinase / ホスファチジルイノシトール3キナーゼ / シナプス可塑性 / 海馬 / シグナル伝達 / 顆粒細胞 / 中心体 / 細胞周期 / 国際情報交換（カナダ） / リン酸化 / 悪性黒色腫 / 燐酸化 / 色素細胞 / malignant melanoma / protein kinase C / phosphorylation / 神経細胞死 / Neuronal death / Protein phosphatase / Gab1 / Dementia / 脂質メッセンジャー / ターゲッティング / アミノ酸バランス / mTOR / チロシンキナーゼ / 情報伝達機構網 / 構造解析 / 創薬 / PAF-アセチルヒドロラーゼ / PLD(ホスホリパーゼD) / PLC(ホスホリパーゼC) / PKC(プロテインキナーゼC) / 核-細胞質間物質輸送 / PI 3キナーゼ / Fas / NO(一酸化窒素) / ホスホリパーゼA / 低分子量G蛋白質 / 核局在化シグナル / チオレドキシン / 一酸化窒素合成酵素 / KN1 / 長期抑圧 / 小脳 / 電気生理 / ヘテロシナプス性長期抑圧 / サイレントシナプス / ノックアウトマウス / シナプス長期抑圧 / 痴呆 / 神経科学 / 脳神経疾患 / 免疫抑制薬 / 抗真菌薬 / ストレス応答 / 細胞内情報伝達 / 細胞内輸送 / モデル生物 / スタチン / コレステロール / がん遺伝子 / GPIアンカー / コバルト / マップキナーゼ / アゾール系 / 薬剤耐性 / 薬剤感受性 / 細胞内カルシウム / チャネル / バルプロ酸 / 低分子量GTP結合タンパク質 / グアニンヌクレオチド交換因子 / 酸化ストレス / 転写因子 / メタ可塑性 / 神経発達 / 中心体複製 / 分裂期 / セパレース / 複製ライセンシング / 国際情報交流（カナダ） / アルツハイマー型認知症 / 前頭側頭葉変性症 / 神経原線維変化 / タウ / 細胞周期調節 / 脳 / 免疫組織化学 / protein kinases / 蛋白-蛋白結合 / 浸潤 / Cキナーゼ / ホスホリパーゼD / protein-protein interaction / invasion / 細胞内シグナリング / Phosphorylation / 肝細胞増殖因子 / アデノウイルスベクター / hepatocyte growth factor / phosphatidylinositol 3-kinase / 遺伝子異常 / 細胞内ジグナル伝達 / 蛋白合成 / Gene mutation / アンカリング蛋白質 / ゴルジ体 / Protein kinases / anchoring proteins / centrosome / Golgi apparatus / 神経細胞 / 変性 / Protein / Neuron / Degeneration / repeated swim / 神経型グルタミン酸トランスポーター / 行動 / 神経回路発達 / シナプス伝達長期抑圧 / ストレス緩衝作用 / 興奮性 / 抑制性神経細胞 Less

ストレス誘発性不安緩衝における海馬歯状回抑制性細胞の重要性Ongoing
- Principal Investigator
  
  安田浩樹
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 46030:Function of nervous system-related
- Research Institution
  Saga University
Analysis on the suppression of cancer metastasis by PKN3 inhibitionPrincipal Investigator
- Principal Investigator
  
  Mukai Hideyuki
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Tumor biology
- Research Institution
  Kobe University
タウ蛋白リン酸化シグナル巨大複合体を介する変性認知症の神経細胞死に関する病態解析
- Principal Investigator
  
  川又敏男
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Kobe University
Involvement of glutamate transporters in central stress response
- Principal Investigator
  
  Hiroki Yasuda
- Project Period (FY)
  2014 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurophysiology / General neuroscience
- Research Institution
  Gunma University
PKN1 regulates metaplasticity in hippocampus
- Principal Investigator
  
  YASUDA Hiroki
- Project Period (FY)
  2011 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurophysiology and muscle physiology
- Research Institution
  Gunma University
Functional analysis of separase and its novel substrate in the licensing of centrosome duplication
- Principal Investigator
  
  TAKAHASHI Mikiko
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Teikyo Heisei University
タウ蛋白とリン酸化酵素複合体の相互作用を介した認知症脳神経細胞死の病態解析
- Principal Investigator
  
  川又敏男
- Project Period (FY)
  2011 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Kobe University
Pharmacogenomic study on the drug-sensitive genes using model organisms
- Principal Investigator
  
  KUNO Takayoshi
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General pharmacology
- Research Institution
  Kobe University
Regulation of the maturation of cerebellar synapses by PKN
- Principal Investigator
  
  YASUDA Hiroki
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurophysiology and muscle physiology
- Research Institution
  Gunma University
Pathological study for a protein anchoring tau kinases and tau phosphatases in Alzheimer brain tissues
- Principal Investigator
  
  KAWAMATA Toshio
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Kobe University
蛋白質リン酸化酵素PKN1ノックアウトマウスを用いた記憶・学習機構の解析Principal Investigator
- Principal Investigator
  
  向井秀幸
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Kobe University
An analysis of the role of protein kinase PKN3 in the progress of cancer and a development of new anticancer agentPrincipal Investigator
- Principal Investigator
  
  MUKAI Hideyuki
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Kobe University
Research of signal transduction to neuronal degeneration mediated by tau-kinases complex in dementia
- Principal Investigator
  
  KAWAMATA Toshio
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Kobe University
Functional regulation of centrosome and Golgi apparatus by signal-anchoring proteins.
- Principal Investigator
  
  ONO Yoshitaka
- Project Period (FY)
  2005 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Functional biochemistry
- Research Institution
  Kobe University
Research of signal transduction to neuronal degeneration mediated by tau phorphorylation in dementia
- Principal Investigator
  
  KAWAMATA Toshio
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Kobe University
To clarify the mechanism of activation of PKN and the interaction with target molecules in vivoPrincipal Investigator
- Principal Investigator
  
  MUKAI Hideyuki
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Living organism molecular science
- Research Institution
  Kobe University
Role of β isoform of protein kinase C in hepatocyte growth factor-induced signal transduction in pigment cells
- Principal Investigator
  
  OKA Masahiro
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Dermatology
- Research Institution
  Kobe University
Study of signal transduction to neuronal death through tau phosphorylation
- Principal Investigator
  
  KAWAMATA Toshio
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Neurology
- Research Institution
  Kobe University
Study of the role of protein kinase C-phosphoipase D signaling pathway in pigment cells.
- Principal Investigator
  
  OKA Masahiro
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Dermatology
- Research Institution
  Kobe University
細胞内情報伝達機構網の研究
- Principal Investigator
  
  西塚泰美
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Creative Basic Research
- Research Institution
  Kobe University
PKNファミリーの細胞内伝達機構における機能解析Principal Investigator
- Principal Investigator
  
  向井秀幸
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Functional biochemistry
- Research Institution
  Kobe University
細胞内増殖機構における蛋白質リン酸化酵素PKNの機能に関する研究
- Principal Investigator
  
  小野功貴
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kobe University
Study on the stress-induced signaling pathway of PKNPrincipal Investigator
- Principal Investigator
  
  MUKAI Hideyuki
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cell biology
- Research Institution
  KOBE UNIVERSITY
細胞内増殖機構における蛋白質リン酸化酵素PKNの機能に関する研究
- Principal Investigator
  
  ONO Yoshitaka
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kobe University
蛋白質燐酸化酵素PKNと相互作用する蛋白因子の同定Principal Investigator
- Principal Investigator
  
  向井秀幸
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Structural biochemistry
- Research Institution
  Kobe University
Studies on the structure and function of protein kinase PKN
- Principal Investigator
  
  ONO Yoshitaka
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Cell biology
- Research Institution
  KOBE UNIVERSITY

[Book] Protein Kinase Technologies, Neuromethods vol.682012
- Author(s)
  Hiroki Yasuda and Hideyuki Mukai
- Total Pages
  12
- Publisher
  Springer
- Data Source
  KAKENHI-PROJECT-23500461
[Book] Neuromethods : Protein Kinase Technologies2011
- Author(s)
  H.Yasuda, H.Mukai
- Publisher
  Springer
- Data Source
  KAKENHI-PROJECT-20500354
[Book] Genome Science2008
- Author(s)
  Mukai, H., et. al.
- Publisher
  Kyoto Hirokawa Publishig Inc(in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590294
[Book] ゲノム科学2008
- Author(s)
  向井秀幸
- Publisher
  京都廣川書店(In press)
- Data Source
  KAKENHI-PROJECT-18590294
[Book] ゲノム科学2008
- Author(s)
  向井秀幸
- Publisher
  京都廣川書店(in press)
- Data Source
  KAKENHI-PROJECT-18022025
[Book] ゲノム科学2008
- Author(s)
  向井秀幸
- Publisher
  京都廣川書店(in press)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590294
[Book] Methods in Enzymology2005
- Author(s)
  Mukai H
- Publisher
  Elsevier (in press)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15510175
[Book] Protein Kinase C Protocols, Methods Mol.Biol.2003
- Author(s)
  Mukai H
- Total Pages
  14
- Publisher
  Humana Press
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15510175
[Book] Neuromethods : Protein Kinase Technologies
- Author(s)
  安田浩樹、向井秀幸
- Publisher
  Springer(in press)
- Data Source
  KAKENHI-PROJECT-20500354
[Journal Article] PKN1 controls the aggregation, spheroid formation, and viability of mouse embryonic fibroblasts in suspension culture2020
- Author(s)
  Mehruba Mona、Siddique Salman Mahmud、Mukai Hideyuki
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 523 Pages: 398-404
- DOI
  10.1016/j.bbrc.2019.12.069
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K07168
[Journal Article] PKN1 kinase-negative knock-in mice develop splenomegaly and leukopenia at advanced age without obvious autoimmune-like phenotypes2019
- Author(s)
  Siddique SM, Kubouchi K, Shinmichi Y, Sawada N, Sugiura R, Itoh Y, Uehara S, Nishimura K, Okamura S, Ohsaki H, Kamoshida S, Yamashita Y, Tamura S, Sonoki T, Matsuoka H, Itoh T, Mukai H.
- Journal Title
  
  Scientific Reports
  
  Volume: 27;9(1) Pages: 13977-13977
- DOI
  10.1038/s41598-019-50419-2
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08821, KAKENHI-PROJECT-19K10050, KAKENHI-PROJECT-19H03376, KAKENHI-PROJECT-17K07168
[Journal Article] Protein kinase N3 promotes bone resorption by osteoclasts in response to Wnt5a-Ror2 signaling2017
- Author(s)
  Uehara S, Udagawa N, Mukai H, Ishihara A, Maeda K, Yamashita T, Murakami K, Nishita M, Nakamura T, Kato S, Minami Y, Takahashi N and Kobayashi Y
- Journal Title
  
  Sci. Signaling
  
  Volume: 10
- DOI
  10.1126/scisignal.aan0023
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K11494, KAKENHI-PROJECT-16K11818, KAKENHI-PROJECT-17K07168, KAKENHI-PROJECT-17K08634, KAKENHI-PROJECT-17K19776, KAKENHI-PROJECT-17K16686, KAKENHI-PROJECT-16H02691, KAKENHI-PROJECT-16H05144, KAKENHI-PROJECT-16H05152, KAKENHI-PROJECT-16H05508, KAKENHI-PROJECT-15K11059, KAKENHI-PROJECT-15K11377
[Journal Article] Impaired lymphocyte trafficking in mice deficient in the kinase activity of PKN1.2017
- Author(s)
  Mashud R, Nomachi A, Hayakawa A, Kubouchi K, Danno S, Hirata T, Matsuo K, Nakayama T, Satoh R, Sugiura R, Abe M, Sakimura K, Wakana S, Ohsaki H, Kamoshida S, Mukai H.
- Journal Title
  
  Sci Rep.
  
  Volume: 7 Issue: 1 Pages: 7663-7663
- DOI
  10.1038/s41598-017-07936-9
- NAID
  120006366660
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K08831, KAKENHI-PROJECT-17K01972, KAKENHI-PROJECT-17K07168, KAKENHI-PROJECT-17K19444, KAKENHI-PROJECT-16H06276, KAKENHI-PROJECT-25000015
[Journal Article] PKN2 is essential for mouse embryonic development and proliferation of mouse fibroblasts2017
- Author(s)
  Danno S, Kubouchi K, Mehruba M, Abe M, Natsume R, Sakimura K, Eguchi S, Oka M, Hirashima M, Yasuda H, Mukai H.
- Journal Title
  
  Genes to Cell
  
  Volume: 22 Pages: 220-236
- DOI
  10.1111/gtc.12470
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H04650, KAKENHI-PROJECT-26350979, KAKENHI-PROJECT-26440020, KAKENHI-PROJECT-26430003
[Journal Article] PKN3 is the major regulator of angiogenesis and tumor metastasis inmice.2016
- Author(s)
  Mukai H, Muramatsu A, Mashud R, Kubouchi K, Tsujimoto S, Hongu T, Kanaho Y, Tsubaki M, Nishida S, Shioi G, Danno S, Mehruba M, Satoh R, Sugiura R.
- Journal Title
  
  Sci Rep.
  
  Volume: 6 Pages: 18979-18979
- DOI
  10.1038/srep18979
- NAID
  120006545244
- Description
  E-pub
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K19001, KAKENHI-PROJECT-15H02503, KAKENHI-PROJECT-26461310
[Journal Article] Turning off of GluN2B subunits and turning on of CICR in hippocampal LTD induction after developmental GluN2 subunit switch.2015
- Author(s)
  Hiroki Yasuda and Hideyuki Mukai
- Journal Title
  
  Hippocampus
  
  Volume: 未定 Pages: 1274-1284
- DOI
  10.1002/hipo.22435
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-23500461, KAKENHI-PROJECT-26430003
[Journal Article] S6 kinase phosphorylated at T229 is involved in tau and actin pathologies in Alzheimer's disease.2015
- Author(s)
  Sonoda Y, Tooyama I, Mukai H, Maeda K, Akiyama H, Kawamata T.
- Journal Title
  
  Neuropathology.
- DOI
  10.1111/neup.12275
- Description
  E-pub
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26461310
[Journal Article] Accumulation of tumor-suppressor PTEN in Alzheimer neurofibrillary tangles2010
- Author(s)
  Sonoda Y, Mukai H, Matsuo K, Takahashi M, Ono Y, Maeda K, Akiyama H, Kawamata T
- Journal Title
  
  Neuroscience Letters
  
  Volume: 471 Pages: 20-24
- NAID
  120003290064
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591024
[Journal Article] Hypotonic Swelling-Induced Activation of Pkn1 Mediates Cell Survival in Cardiac Myocytes2010
- Author(s)
  向井秀幸、小野功貴, 他
- Journal Title
  
  Am J Physiol Heart Circ Physiol. Vol.300、No.1
  
  Pages: 191-200
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20500354
[Journal Article] Accumulation of tumor-suppressor PTEN in Alzheimer neurofibrillary tangles2010
- Author(s)
  Sonoda Y, Mukai H, Matsuo K, Takahashi M, Ono Y, Maeda K, Akiyama H, Kawamata T
- Journal Title
  
  Neuroscience Letters 471
  
  Pages: 20-24
- NAID
  120003290064
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591024
[Journal Article] Accumulation of tumor-suppressor PTEN in Alzheimer neurofibrillary tangles2010
- Author(s)
  向井秀幸、小野功貴, 他
- Journal Title
  
  Neurosci Lett. Vol.471、No.1
  
  Pages: 20-24
- NAID
  120003290064
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20500354
[Journal Article] Accumulation of tumor-suppressor PTEN in Alzheimer neurofibrillary tangles.2010
- Author(s)
  Sonoda Y, Mukai H, Matsuo K, Takahashi M, Ono Y, Maeda K, Akiyama H, Kawamata T.
- Journal Title
  
  Neuroscience Letters 471
  
  Pages: 20-24
- NAID
  120003290064
- Data Source
  KAKENHI-PROJECT-20591024
[Journal Article] Development of an intracellularly acting inhibitory peptide selective for PKN.2009
- Author(s)
  志賀一博、小野功貴、向井秀幸, 他
- Journal Title
  
  Biochem J. Vol.425、No.2
  
  Pages: 445-543
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20500354
[Journal Article] A peptidyl-prolyl isomerase, FKBP12, accumulates in Alzheimer neurofibrillary tangles.2009
- Author(s)
  Sugata H, Matsuo K, Nakagawa T, Takahashi M, Mukai H, Ono Y, Maeda K, Akiyama H, Kawamata T.
- Journal Title
  
  Neuroscience Letters 459
  
  Pages: 96-99
- Data Source
  KAKENHI-PROJECT-20591024
[Journal Article] A peptidyl-prolyl isomerase, FKBP12, accumulates in Alzheimer neurofibrillary tangles2009
- Author(s)
  小野功貴、向井秀幸, 他
- Journal Title
  
  Neurosci.Lett. Vol.459、No.2
  
  Pages: 96-99
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20500354
[Journal Article] A peptidyl-proryl isomerase, FKBP12, accumulates in Alzheimer neurofibrillary tangles2009
- Author(s)
  Sugata H, Matsuo K, Nakagawa T, Takahashi M, Mukai H, Ono Y, Maeda K, Akiyama H, Kawamata T
- Journal Title
  
  Neuroscience Letters 459
  
  Pages: 96-99
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591024
[Journal Article] Calcineurin-mediated dephosphorylation of c-Jun Ser-243 is required for c-Jun protein stability and cell transformation2008
- Author(s)
  吉川潮、向井秀幸, 他
- Journal Title
  
  Oncogene Vol.27、No.17
  
  Pages: 2422-2429
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20500354
[Journal Article] Fragmentation of Protein Kinase N(PKN)in the Hydrocephalic Rat Brain2007
- Author(s)
  Okii, N, Amano, T, Seki, T, Matsubayashi, H, Mukai, H, Ono, Y, Kurisu, K, Sakai, N
- Journal Title
  
  Acta Histochem Cytochem 40
  
  Pages: 113-21
- NAID
  110006633421
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590294
[Journal Article] Purification and kinase assay of PKN2006
- Author(s)
  Mukai, H
- Journal Title
  
  Methods Enzymol 406
  
  Pages: 234-250
- NAID
  120000946410
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17370049
[Journal Article] Purification and kinase assay of PKN.2006
- Author(s)
  Mukai, H.
- Journal Title
  
  Methods Enzymol. 406
  
  Pages: 234-250
- NAID
  120000946410
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17370049
[Journal Article] Purification and Kinase assay of PKN2006
- Author(s)
  Mukai, H.
- Journal Title
  
  Methods in Enzymology 406
  
  Pages: 234-250
- NAID
  120000946410
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590294
[Journal Article] Purification and kinase assay of PKN2006
- Author(s)
  Mukai, H
- Journal Title
  
  Methods Enzymol. 406
  
  Pages: 234-250
- NAID
  120000946410
- Data Source
  KAKENHI-PROJECT-17370049
[Journal Article] Purification, kinase assay of PKN2006
- Author(s)
  Mukai, H, Ono, Y
- Journal Title
  
  Methods Enzymol 406
  
  Pages: 234-50
- NAID
  120000946410
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590294
[Journal Article] Purification and Kinase assay of PKN2006
- Author(s)
  Mukai, H.
- Journal Title
  
  Methods in Enzymology 406
  
  Pages: 234-250
- NAID
  120000946410
- Data Source
  KAKENHI-PROJECT-18022025
[Journal Article] Purification and Kinase assay of PKN2005
- Author(s)
  Mukai, H., Ono, Y
- Journal Title
  
  Methods in Enzymology, Small GTPases(Elsevier) (in press)
- NAID
  120000946410
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15510175
[Journal Article] Formation of morphologically similar globular aggregates from diverse aggregation-prone proteins in mammalian cells.2005
- Author(s)
  Mukai, H.
- Journal Title
  
  Proc. Natl. Acad. Sci. USA 102
  
  Pages: 10887-10892
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17370049
[Journal Article] Formation of morphologically similar globular aggregates from diverse aggregation-prone proteins in mammalian cells2005
- Author(s)
  Mukai, H
- Journal Title
  
  Proc. Natl. Acad. Sci. USA 102
  
  Pages: 10887-10892
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17370049
[Journal Article] The role of the regulatory subunit of fission yeast calcineurin for in vivo activity and its relevance to FK506 sensitivity.2005
- Author(s)
  Sio SO, Suehiro T, Sugiura R, Takeuchi M, Mukai H, Kuno T
- Journal Title
  
  J Biol Chem. 280(13)
  
  Pages: 12231-12238
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15510175
[Journal Article] Centrosome-targeting region of CG-NAP causes centrosome amplification by recruiting cyclin E-cdk2 complex.2005
- Author(s)
  Nishimura T, Takahashi M, Kim HS, Mukai H, Ono Y
- Journal Title
  
  Genes Cells. 10(1)
  
  Pages: 75-86
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15510175
[Journal Article] Involvement of protein kinase PKN1 in G(2)/M delay caused by arsenite.2005
- Author(s)
  Isagawa T, Takahashi M, Kato T Jr, Mukai H, Ono Y
- Journal Title
  
  Mol Carcinog. 43(1)
  
  Pages: 1-12
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15510175
[Journal Article] Formation of morphologically similar globular aggregates from diverse aggregation-prone proteins in mammalian cells.2005
- Author(s)
  Mukai, H.
- Journal Title
  
  Proc.Natl.Acad.Sci.USA 102
  
  Pages: 10887-10892
- Data Source
  KAKENHI-PROJECT-17370049
[Journal Article] Protein kinase PKN1 associates with TRAF2 and is involved in TRAF2-NF-kappaB signaling pathway.2004
- Author(s)
  Gotoh Y, Oishi K, Shibata H, Yamagiwa A, Isagawa T, Nishimura T, Goyama E, Takahashi M, Mukai H, Ono Y
- Journal Title
  
  Biochem Biophys Res Commun. 314(3)
  
  Pages: 688-694
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15510175
[Journal Article] Lbc proto-oncogene product binds to and could be negatively regulated by metastasis suppressor nm23-H2.2004
- Author(s)
  Iwashita S, Fujii M, Mukai H, Ono Y, Miyamoto M
- Journal Title
  
  Biochem Biophys Res Commun. 320(4)
  
  Pages: 1063-1068
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15510175
[Journal Article] Expression and purification of protein kinase C from insect cells2003
- Author(s)
  Mukai, H., Ono, Y
- Journal Title
  
  Methods Mol.Biol., Protein Kinase C Protocols)(Totowa, NJ)(Humana Press Inc.) 233
  
  Pages: 21-34
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15510175
[Journal Article] Calcineurin-mediated dephosphorylation of c-Jun Ser-243 is required for c-Jun protein stability and cell transformation
- Author(s)
  Huang, CC, Wang, JM, Kikkawa, U, Mukai, H, Shen, MR, Morita, I, Chen, BK, Chang, WC
- Journal Title
  
  Oncogene(2007) (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590294
[Patent] PKN1ノックアウト動物、および向精神薬開発法2005
- Inventor(s)
  向井秀幸
- Industrial Property Rights Holder
  向井秀幸
- Industrial Property Number
  2005-057600
- Filing Date
  2005-03-02
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15510175
[Presentation] 高齢PKN1キナーゼネガティブノックインマウスは、高齢PKN1ノックアウトマウスと異なった表現型を示す2019
- Author(s)
  Mashud Siddique Salman and Hideyuki Mukai
- Organizer
  第66回日本生化学会近畿支部例会
- Data Source
  KAKENHI-PROJECT-17K07168
[Presentation] アルカリ金属イオンが細胞内シグナル伝達を制御する2018
- Author(s)
  窪内康二、向井秀幸
- Organizer
  第91回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-17K07168
[Presentation] PKN1による海馬歯状回興奮性と不安の制御2017
- Author(s)
  安田浩樹、メヘルバモナ、向井秀幸
- Organizer
  第40回日本神経科学大会
- Data Source
  KAKENHI-PROJECT-26430003
[Presentation] PKN1はリンパ球の細胞運動・トラフィッキングを制御する2017
- Author(s)
  窪内康二、團野紗莉、野町昭、平田多佳子、松尾一彦、中山隆志、佐藤亮介、杉浦麗子、阿部学、崎村建司、若菜茂晴、大崎博之、鴨志田伸吾、向井秀幸
- Organizer
  ConBio2017
- Data Source
  KAKENHI-PROJECT-17K07168
[Presentation] PKN1 normalizes dentate gyrus excitability through glutamate transpoter regulation and controls anxiety2017
- Author(s)
  Hiroki Yasuda, Mona Mehruba, and Hideyuki Mukai
- Organizer
  第４０回　日本神経科学大会
- Data Source
  KAKENHI-PROJECT-17K07168
[Presentation] グルタミン酸トランスポーターを介したPKN1による代謝型グルタミン酸受容体機能制御2014
- Author(s)
  安田浩樹、山本光、川又敏夫、向井秀幸
- Organizer
  第37回日本神経科学学会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2014-09-11
- Data Source
  KAKENHI-PROJECT-23500461
[Presentation] グルタミン酸トランスポーターを介したPKN1による代謝型グルタミン酸受容体機能制御2014
- Author(s)
  安田浩樹、山本光、川又敏夫、向井秀幸
- Organizer
  第37回日本神経科学学会
- Place of Presentation
  横浜
- Year and Date
  2014-09-11
- Data Source
  KAKENHI-PROJECT-26430003
[Presentation] Association of neuronal polypyrimidine tract binding protein with neurofibrillary tangles in Alzheimer brain tissues2013
- Author(s)
  Ito Y, Pan H-Y, Sonoda Y, Mukai H, Takahashi M, Maeda K, Akiyama H, Yoshimura N, Kawamata T
- Organizer
  The 43rd annual meeting of the Society for Neuroscience
- Place of Presentation
  San Diego (U.S.A.)
- Data Source
  KAKENHI-PROJECT-23591276
[Presentation] Serine/threonine-protein kinase CHK1 associates with Alzheimer neurofibrillary tangles2013
- Author(s)
  Pan H-Y, Sonoda Y, Mukai H, Takahashi M, Maeda K, Yasuhara O, Akiyama H, Kawamata T
- Organizer
  The 43rd annual meeting of the Society for Neuroscience
- Place of Presentation
  San Diego (U.S.A.)
- Data Source
  KAKENHI-PROJECT-23591276
[Presentation] p70 S6 kinase accumulates in neuronal inclusion bodies in Alzheimer brain tissues2012
- Author(s)
  Sonoda Y, Edatsugi S, Mukai H, Takahashi M, Ono Y, Akiyama H, Maeda K, Kawamata T
- Organizer
  Annual Meeting of Society for Neuroscience 2012
- Place of Presentation
  New Orleans (USA)
- Data Source
  KAKENHI-PROJECT-23591276
[Presentation] Association of protein kinase C delta with neurofibrillary tangles in Alzheimer brain tissues.2010
- Author(s)
  Sonoda Y, Matsuo K, Takahashi M, Mukai H, Ono Y, Maeda K, Akiyama H, Kawamata T
- Organizer
  40^<th> Annual Meeting of Society for Neuroscience
- Place of Presentation
  San Diego
- Year and Date
  2010-11-14
- Data Source
  KAKENHI-PROJECT-20591024
[Presentation] Tumor suppressor PTEN is associated with neurofibrillary tangles in Alzheimer brain tissues.2009
- Author(s)
  Sonoda Y, Matsuo K, Takahashi M, Mukai H, Ono Y, Maeda K, Akiyama H, Kawamata T
- Organizer
  39^<th> Annual Meeting of Society for Neuroscience
- Place of Presentation
  Chicago
- Year and Date
  2009-12-18
- Data Source
  KAKENHI-PROJECT-20591024
[Presentation] FKBP12 is associated with neurofibrillary tangles in Alzheimer brain tissues.2008
- Author(s)
  菅田陽怜, 松尾和彦, 高橋美樹子, 向井秀幸, 小野功貴, 前田潔, 川又敏男
- Organizer
  38^<th> Annual Meeting of Society for Neuroscience
- Place of Presentation
  Washington DC
- Year and Date
  2008-11-16
- Data Source
  KAKENHI-PROJECT-20591024
[Presentation] アルツハイマー病におけるPDK1活性化の検討2008
- Author(s)
  中川泰介、菅田陽怜、松尾和彦、高橋美樹子、向井秀幸、小野功貴、前田潔、秋山治彦、川又敏男
- Organizer
  第27回日本認知症学会
- Place of Presentation
  前橋
- Year and Date
  2008-10-11
- Data Source
  KAKENHI-PROJECT-20591024
[Presentation] バイオアップデート-Web2.0自律更新型日本語オープンアクセスジャーナルの公開と研究者口コミ情報の共有-2007
- Author(s)
  向井秀幸
- Organizer
  BMB2007
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2007-12-11
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590294
[Presentation] An identification of the substrate recognition motif and a development of inhibitory peptide for PKN2007
- Author(s)
  Shiga, K, Ueki, K, Hutti, J, Maeda, T, Turk, B, Ono, Y, Mukai, H
- Organizer
  BMB2007
- Place of Presentation
  Pacifico Yokohama
- Year and Date
  2007-12-11
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590294
[Presentation] バイオアップデート-Web2.0自律更新型日本語オープンアクセスジャーナルの公開と研究者口コミ情報の共有-2007
- Author(s)
  向井秀幸
- Organizer
  2007年12月11日
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2007-12-11
- Data Source
  KAKENHI-PROJECT-18022025
[Presentation] A Web 2.0 self-revisable Japanese open access journal and a shari ng of buzz information among biologists2007
- Author(s)
  Mukai, H, Kuno, Y
- Organizer
  BMB2007
- Place of Presentation
  Pacifico Yokohama
- Year and Date
  2007-12-11
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590294
[Presentation] バイオアップデートー-Web2.0自律更新型日本語オープンアクセスジャーナルの公開と研究者口コミ情報の共有-2007
- Author(s)
  向井秀幸
- Organizer
  2007年12月11日
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2007-12-11
- Data Source
  KAKENHI-PROJECT-18590294

1. ONO Yoshitaka (10243297)

# of Collaborated Projects: 10 results

# of Collaborated Products: 12 results
2. TAKAHASHI Mikiko (90324938)

# of Collaborated Projects: 7 results

# of Collaborated Products: 12 results
3. KAWAMATA Toshio (70214690)

# of Collaborated Projects: 6 results

# of Collaborated Products: 13 results
4. MAEDA Kiyoshi (80116251)

# of Collaborated Projects: 6 results

# of Collaborated Products: 13 results
5. YASUDA Hiroki (60294071)

# of Collaborated Projects: 4 results

# of Collaborated Products: 8 results
6. OKA Masahiro (30252761)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. KUNO Takayoshi (50144564)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. MA Yan (70457050)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. KOJIMA Nobuhiko (80215251)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. TADA Shusuke (00216970)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. MATSUO Kazuhiko (70599753)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. OHNISHI Hiroshi (70334125)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 西塚泰美 (10025546)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 米澤一仁 (70283900)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 斎藤尚亮 (60178499)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 吉川潮 (40150354)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 深見泰夫 (00156746)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 横山光宏 (40135794)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 米原伸 (00124503)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 福井泰久 (00181248)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. 山村博平 (90030882)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. 井上圭三 (30072937)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. 淀井淳司 (80108993)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. 秋山治彦 (20231839)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
25. 惣谷和広 (80415207)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. NAKAMURA Hiroshi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
27. NISHITA MICHIRU

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
28. Kobayashi Yasuhiro

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
29. Sato Tomomi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
30. NATSUME Rie

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
31. EGUCHI Satoshi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
32. 本宮綱記

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
33. 金保安則

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
34. 上原俊介

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
35. 中村美どり

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
36. 宇田川信之

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
37. 村上康平

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
38. 高橋直之

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
39. 山下照仁

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
40. 荒敏昭

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
41. 中村浩彰

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
42. 南康博

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
43. 平田多佳子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
44. 阿部学

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
45. 崎村建司

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
46. 旦慎吾

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
47. 園木孝志

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
48. 杉浦麗子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

MUKAI HIDEYUKI 向井 秀幸

MUKAI Hideyuki 向井 秀幸

Research Projects

Research Products

Co-Researchers

ストレス誘発性不安緩衝における海馬歯状回抑制性細胞の重要性Ongoing

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analysis on the suppression of cancer metastasis by PKN3 inhibitionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

蛋白質リン酸化酵素PKN1ノックアウトマウスを用いた記憶・学習機構の解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

An analysis of the role of protein kinase PKN3 in the progress of cancer and a development of new anticancer agentPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

MUKAI HIDEYUKI 向井秀幸

MUKAI Hideyuki 向井秀幸