Kobayashi Naohiro 小林直宏

… Alternative Names

小林直宏コバヤシナオヒロ

KOBAYASHI Naohiro 小林直宏

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Researcher Number	80272160
Other IDs
Affiliation (Current)	2025: 国立研究開発法人理化学研究所, 生命医科学研究センター, 上級研究員
Affiliation (based on the past Project Information) *help	2025: 国立研究開発法人理化学研究所, 生命医科学研究センター, 上級研究員 2022: 国立研究開発法人理化学研究所, 生命機能科学研究センター, 上級研究員 2019 – 2020: 国立研究開発法人理化学研究所, 放射光科学研究センター, 上級研究員 2018: 大阪大学, 蛋白質研究所, 特任准教授(常勤) 2017: 大阪大学, 蛋白質研究所, 特任准教授 … More 2016 – 2017: 大阪大学, たんぱく質研究所, 特任准教授(常勤) 2015: 大阪大学, たんぱく質研究所, 研究員 2012 – 2013: 大阪大学, たんぱく質研究所, 研究員 2010 – 2011: 大阪大学, 蛋白質研究所, 特任研究員 1998: 筑波大, 応用生物化学系, 助手 1996 – 1997: 筑波大学, 応用生物化学系, 助手 Less
Review Section/Research Field	Principal Investigator Basic Section 43040:Biophysics-related / Structural biochemistry / Bioproduction chemistry/Bioorganic chemistry Except Principal Investigator Medium-sized Section 32:Physical chemistry, functional solid state chemistry, and related fields / Structural biochemistry
Keywords	Principal Investigator データベース / NMR / 自動解析 / 自動化 / 核磁気共鳴 / フォールディング / 深層学習 / 高度化 / 構造解析 / 人工知能 … More / モデリング / ホモロジーモデリング / ＮＭＲ / 核磁気共鳴法 / 最適化 / 学習型 / GPU / 帰属 / シグナル / 機械学習 / シグナル帰属 / 相補複合体 / ペプチドフラグメント / プロテインGB1ドメイン / 動力学的解析 / CDスペクトル / 二次元NMRスペクトル / 蛋白質高次構造 / フラグメント / ペプチド合成 / ペプチド … More Except Principal Investigator 自動解析 / 超高分解能 / 固体ＮＭＲ / 自動構造決定 / 自動化 / 立体構造 / 蛋白質 / NMR Less

機械学習・理論計算・実測データを活用した生体高分子の動的状態を可視化する新規技術Principal Investigator
- Principal Investigator
  
  小林直宏
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 43040:Biophysics-related
- Research Institution
  Institute of Physical and Chemical Research
超高分解能固体NMRと自動解析による非結晶性生体高分子と先端材料構造解析の新機軸
- Principal Investigator
  
  石井佳誉
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Challenging Research (Pioneering)
- Review Section
  
  Medium-sized Section 32:Physical chemistry, functional solid state chemistry, and related fields
- Research Institution
  Tokyo Institute of Technology
Development of fully automated NMR data analysis assisted by AIPrincipal Investigator
- Principal Investigator
  
  Kobayashi Naohiro
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 43040:Biophysics-related
- Research Institution
  Institute of Physical and Chemical Research
  Osaka University
NMR Molecular Replacement Method
- Principal Investigator
  
  Kojima Chojiro
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Structural biochemistry
- Research Institution
  Yokohama National University
Development of NMR drug discovery pipeline using databasePrincipal Investigator
- Principal Investigator
  
  Kobayashi Naohiro
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Structural biochemistry
- Research Institution
  Osaka University
Automated NMR signal assignment with self-learning system efficently using databasePrincipal Investigator
- Principal Investigator
  
  KOBAYASHI Naohiro
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Structural biochemistry
- Research Institution
  Osaka University
フラグメント間相互作用を利用した蛋白質立体構造形成機構の研究Principal Investigator
- Principal Investigator
  
  小林直宏
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Bioproduction chemistry/Bioorganic chemistry
- Research Institution
  University of Tsukuba
合成ペプチドによる蛋白質立体構造形成過程の研究Principal Investigator
- Principal Investigator
  
  小林直宏
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Bioproduction chemistry/Bioorganic chemistry
- Research Institution
  University of Tsukuba

All 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010

All Journal Article Presentation

[Journal Article] Mechanism of hERG inhibition by gating-modifier toxin, APETx1, deduced by functional characterization2021
- Author(s)
  Matsumura Kazuki、Shimomura Takushi、Kubo Yoshihiro、Oka Takayuki、Kobayashi Naohiro、Imai Shunsuke、Yanase Naomi、Akimoto Madoka、Fukuda Masahiro、Yokogawa Mariko、Ikeda Kazuyoshi、Kurita Jun-ichi、Nishimura Yoshifumi、Shimada Ichio、Osawa Masanori
- Journal Title
  
  BMC Molecular and Cell Biology
  
  Volume: 22 Issue: 1 Pages: 1-16
- DOI
  10.1186/s12860-020-00337-3
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07284, KAKENHI-PUBLICLY-19H04973, KAKENHI-PUBLICLY-20H05449, KAKENHI-PROJECT-20H03424, KAKENHI-PROJECT-18K06152, KAKENHI-PROJECT-18K06606, KAKENHI-PROJECT-17H06097
[Journal Article] Robust folding of a de novo designed ideal protein even with most of the core mutated to valine.2020
- Author(s)
  R. Koga, M. Yamamoto, K. Takahiro, N. Kobayashi, T. Sugiki, T. Fujiwara and N. Koga
- Journal Title
  
  Proc. Natl. Acad. Sci. USA
  
  Volume: 117 Issue: 49 Pages: 31149-31156
- DOI
  10.1073/pnas.2002120117
- NAID
  120006952207
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06152, KAKENHI-PLANNED-18H05420
[Journal Article] Crystal contact-free conformation of an intrinsically flexible loop in protein crystal: Tim21 as the case study2020
- Author(s)
  Bala Siqin、Shinya Shoko、Srivastava Arpita、Ishikawa Marie、Shimada Atsushi、Kobayashi Naohiro、Kojima Chojiro、Tama Florence、Miyashita Osamu、Kohda Daisuke
- Journal Title
  
  Biochimica et Biophysica Acta (BBA) - General Subjects
  
  Volume: 1864 Issue: 2 Pages: 129418-129418
- DOI
  10.1016/j.bbagen.2019.129418
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06152, KAKENHI-PUBLICLY-19H04856, KAKENHI-WRAPUP-19H05452, KAKENHI-PROJECT-17H03641, KAKENHI-PROJECT-18J01012, KAKENHI-PROJECT-17K07309
[Journal Article] Nucleus Accumbens-Associated Protein 1 Binds DNA Directly through the BEN Domain in a Sequence-Specific Manner2020
- Author(s)
  Nakayama Naomi、Sakashita Gyosuke、Nagata Takashi、Kobayashi Naohiro、Yoshida Hisashi、Park Sam-Yong、Nariai Yuko、Kato Hiroaki、Obayashi Eiji、Nakayama Kentaro、Kyo Satoru、Urano Takeshi
- Journal Title
  
  Biomedicines
  
  Volume: 8 Issue: 12 Pages: 608-608
- DOI
  10.3390/biomedicines8120608
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K07307, KAKENHI-PROJECT-18K06086, KAKENHI-PROJECT-18K06152, KAKENHI-PROJECT-20H01007
[Journal Article] Solution structure of Gaussia Luciferase with five disulfide bonds and identification of a putative coelenterazine binding cavity by heteronuclear NMR.2020
- Author(s)
  N. Wu, N. Kobayashi, K. Tsuda, S. Unzai, T. Saotome, Y. Kuroda and T. Yamazaki.
- Journal Title
  
  Sci. Rep.
  
  Volume: 10 Issue: 1 Pages: 20069-20069
- DOI
  10.1038/s41598-020-76486-4
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06152, KAKENHI-PROJECT-18H02385
[Journal Article] H, 13C and 15N resonance assignment of the YTH domain of YTHDC2.2020
- Author(s)
  F. He, R. Endo, K. Kuwasako, M. Takahashi, K. Tsuda, T. Nagata, S. Watanabe, A. Tanaka, N. Kobayashi, T. Kigawa, P. Guentert, M. Shirouzu, S. Yokoyama and Y. Muto.
- Journal Title
  
  Biomol. NMR Assign.
  
  Volume: 15 Issue: 1 Pages: 1-7
- DOI
  10.1007/s12104-020-09974-3
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06152, KAKENHI-PROJECT-20K06508
[Journal Article] BioMagResBank (BMRB) as a Resource for Structural Biology2020
- Author(s)
  Romero Pedro R.、Kobayashi Naohiro、Wedell Jonathan R.、Baskaran Kumaran、Iwata Takeshi、Yokochi Masashi、Maziuk Dimitri、Yao Hongyang、Fujiwara Toshimichi、Kurusu Genji、Ulrich Eldon L.、Hoch Jeffrey C.、Markley John L.
- Journal Title
  
  Methods Molelcular Biology
  
  Volume: 14 Pages: 187-218
- DOI
  10.1007/978-1-0716-0270-6_14
- ISBN
  9781071602690, 9781071602706
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06152
[Journal Article] How Does the Recently Discovered Peptide MIP Exhibit Much Higher Binding Affinity than an Anticancer Protein p53 for an Oncoprotein MDM22019
- Author(s)
  Yamada Tatsuya、Hayashi Tomohiko、Hikiri Simon、Kobayashi Naohiro、Yanagawa Hiroshi、Ikeguchi Mitsunori、Katahira Masato、Nagata Takashi、Kinoshita Masahiro
- Journal Title
  
  Journal of Chemical Information and Modeling
  
  Volume: 59 Issue: 8 Pages: 3533-3544
- DOI
  10.1021/acs.jcim.9b00226
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06152, KAKENHI-PROJECT-19K14674, KAKENHI-PLANNED-18H05426, KAKENHI-PROJECT-17H03663, KAKENHI-PUBLICLY-17H05878, KAKENHI-PROJECT-17K07307
[Journal Article] Noise peak filtering in multi-dimensional NMR spectra using convolutional neural networks2018
- Author(s)
  Kobayashi, N., Hattori, Y., Nagata, T., Shinya, S., Guentert, P., Kojima, C., Fujiwara, T.
- Journal Title
  
  Bioinformatics
  
  Volume: 34 Issue: 24 Pages: 4300-4301
- DOI
  10.1093/bioinformatics/bty581
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K07312, KAKENHI-PROJECT-18K06152, KAKENHI-PUBLICLY-17H05836, KAKENHI-PUBLICLY-17H05873, KAKENHI-PROJECT-18J01012, KAKENHI-PROJECT-17H03641
[Journal Article] Conjugation of two RNA aptamers improves binding affinity to AML1 Runt domain2017
- Author(s)
  Nomura Yusuke、Yamazaki Kaori、Amano Ryo、Takada Kenta、Nagata Takashi、Kobayashi Naohiro、Tanaka Yoichiro、Fukunaga Junichi、Katahira Masato、Kozu Tomoko、Nakamura Yoshikazu、Haishima Yuji、Torigoe Hidetaka、Sakamoto Taiichi
- Journal Title
  
  J Biochem
  
  Volume: 162 Issue: 6 Pages: 431-436
- DOI
  10.1093/jb/mvx049
- NAID
  40021421327
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K07307, KAKENHI-PUBLICLY-17H05878, KAKENHI-PROJECT-15K06970, KAKENHI-PROJECT-26440026
[Journal Article] Backbone and side chain assignments of the second RNA-binding domain of Musashi-1 in its free form and in complex with 5-mer RNA2017
- Author(s)
  Iwaoka Ryo、Nagata Takashi、Tsuda Kengo、Imai Takao、Okano Hideyuki、Kobayashi Naohiro、Katahira Masato
- Journal Title
  
  Biomol NMR Assign
  
  Volume: 11 Issue: 2 Pages: 265-268
- DOI
  10.1007/s12104-017-9760-9
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K07307, KAKENHI-PUBLICLY-17H05878, KAKENHI-PROJECT-15K06970, KAKENHI-PROJECT-26440026
[Journal Article] nmrML: A Community Supported Open Data Standard for the Description, Storage, and Exchange of NMR Data2017
- Author(s)
  Schober D., Jacob D., W.M., Cruz J.A.、Marcu A.、Grant J.R.、Moing A.、Deborde C.、de Figueiredo L.F.、Haug K.、Rocca-Serra P.、Easton J.、Ebbels T.M. D.、Yokochi M.、Kobayashi N.、... Neumann S.
- Journal Title
  
  Analytical Chemistry
  
  Volume: 90 Issue: 1 Pages: 649-656
- DOI
  10.1021/acs.analchem.7b02795
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K06970
[Journal Article] Solution structure of the first RNA recognition motif domain of human spliceosomal protein SF3b49 and its mode of interaction with a SF3b145 fragment2017
- Author(s)
  Kuwasako, K.
- Journal Title
  
  Protein Science
  
  Volume: 26 Issue: 2 Pages: 280-290
- DOI
  10.1002/pro.3080
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-15H01548, KAKENHI-PROJECT-16H04756, KAKENHI-PROJECT-15K06945, KAKENHI-PROJECT-15K06970, KAKENHI-PROJECT-15K06982, KAKENHI-PROJECT-17K07312
[Journal Article] Modern Technologies of Solution Nuclear Magnetic Resonance Spectroscopy for Three-dimensional Structure Determination of Proteins Open Avenues for Life Scientists2017
- Author(s)
  Sugiki Toshihiko、Kobayashi Naohiro、Fujiwara Toshimichi
- Journal Title
  
  Computational and Structural Biotechnology Journal
  
  Volume: 15 Pages: 328-339
- DOI
  10.1016/j.csbj.2017.04.001
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K06970
[Journal Article] OneDep: Unified wwPDB System for Deposition, Biocuration, and Validation of Macromolecular Structures in the PDB Archive.2017
- Author(s)
  Young JY, Westbrook JD, Feng Z, Sala R, Peisach E, Oldfield TJ, Sen S, Gutmanas A, Armstrong DR, Berrisford JM, Chen L, Chen M, Di Costanzo L, Dimitropoulos D, Gao G, Ghosh S, Gore S, Guranovic V, Hendrickx PM, Hudson BP, Igarashi R, Ikegawa Y, Kobayashi N et al.
- Journal Title
  
  Structure
  
  Volume: 25 Issue: 3 Pages: 536-545
- DOI
  10.1016/j.str.2017.01.004
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K06970
[Journal Article] Publication of nuclear magnetic resonance experimental data with semantic web technology and the application thereof to biomedical research of proteins2016
- Author(s)
  Masashi Yokochi, Naohiro Kobayashi, Eldon L. Ulrich, Akira R. Kinjo, Takeshi Iwata, Yannis E. Ioannidis, Miron Livny, John L. Markley, Haruki Nakamura, Chojiro Kojima, and Toshimichi Fujiwara
- Journal Title
  
  J. Biomed. Semant.
  
  Volume: 7 Pages: 16-16
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K14681
[Journal Article] Publication of nuclear magnetic resonance experimental data with semantic web technology and the application thereof to biomedical research of proteins2016
- Author(s)
  Yokochi Masashi, Kobayashi Naohiro, Ulrich Eldon, Kinjo Akira, Iwata Takeshi, Ioannidis Yannis, Livny Miron, Markley John, Nakamura Haruki, Kojima Chojiro, Fujiwara Toshimichi
- Journal Title
  
  Journal of Biomedical Semantics
  
  Volume: 7 Issue: 1 Pages: 1-4
- DOI
  10.1186/s13326-016-0057-1
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K06970
[Journal Article] A robust method for quantitative identification of ordered cores in an ensemble of biomolecular structures by non-linear multi-dimensional scaling using inter-atomic distance variance matrix2014
- Author(s)
  Naohiro Kobayashi
- Journal Title
  
  J. Biomol. NMR
  
  Volume: 58巻 Issue: 1 Pages: 61-67
- DOI
  10.1007/s10858-013-9805-z
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22570116
[Journal Article] 1H, 13C, and 15N resonance assignments of the dsRBDs of mouse RNA helicase A2013
- Author(s)
  Takashi Nagata T, Kengo Tsuda, Naohiro Kobayashi, Peter Guntert, Shigeyuki Yokoyama, and Yutaka Muto
- Journal Title
  
  Biomolecular NMR Assignment
  
  Volume: 7巻 Issue: 1 Pages: 69-72
- DOI
  10.1007/s12104-012-9380-3
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22570116, KAKENHI-PROJECT-23370080, KAKENHI-PROJECT-23570146, KAKENHI-PUBLICLY-24113710, KAKENHI-PROJECT-25440032
[Journal Article] ビッグデータ時代の生体高分子ＮＭＲデータベース、BioMagResBank (BMRB)　その有効利用とわが国における現状2013
- Author(s)
  小林直宏
- Journal Title
  
  日本核磁気共鳴学会機関誌
  
  Volume: 4 Pages: 121-124
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22570116
[Journal Article] ビッグデータ時代の生体高分子NMRデータベース、BioMagResBank (BMRB)その有効利用とわが国における現状2013
- Author(s)
  小林直宏
- Journal Title
  
  日本核磁気共鳴学会機関誌
  
  Volume: 58巻 Pages: 121-124
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22570116
[Journal Article] Solution structures of the double-stranded RNA-binding domains from rna helicase A2012
- Author(s)
  Takashi Nagata, Kengo Tsuda, Naohiro Kobayashi, Mikako Shirouzu, Takanori, Kigawa, Peter Guntert, Shigeyuki Yokoyama, and Yutaka Muto
- Journal Title
  
  Proteins
  
  Volume: 80巻 Issue: 6 Pages: 1699-1706
- DOI
  10.1002/prot.24059
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22570116, KAKENHI-PROJECT-23570146
[Journal Article] Structural insight into the interaction of ADP-ribose with the PARP WWE domains2012
- Author(s)
  Fahu He, Kengo Tsuda, Mari Takahashi, Keiko Kuwasako, Takako Terada, Mikako Shirouzu, Satoru Watanabe, Takanori Kigawa, Naohiro Kobayashi, Peter Guntert, Shigeyuki Yokoyama, Yutaka Muto
- Journal Title
  
  FEBS Lett.
  
  Volume: 586巻 Issue: 21 Pages: 3858-3864
- DOI
  10.1016/j.febslet.2012.09.009
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22570116
[Journal Article] Structure of Musashi1 in a complex with target RNA : The role of aromatic stacking interactions2012
- Author(s)
  Ohyama, T., Nagata, T., Tsuda, K., Kobayashi, N., Imai, T., Okano, H., Yamazaki, T. and Katahira, M
- Journal Title
  
  Nucleic Acids Res
  
  Volume: 10 Issue: 7 Pages: 3218-3231
- DOI
  10.1093/nar/gkr1139
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21370047, KAKENHI-PROJECT-22570116, KAKENHI-PROJECT-23570146, KAKENHI-PROJECT-23657072, KAKENHI-PUBLICLY-24121714
[Journal Article] NMR study of xenotropic murine leukemia virus-related virus protease in a complex with amprenavir2012
- Author(s)
  Ayako Furukawa, Hideyasu Okamura, Ryo Morishita, Satoko Matsunaga, Naohiro Kobayashi, Takahisa Ikegami, Tsutomu Kodaki, Akifumi Takaori-Kondo, Ryo Akihide, Takashi Nagata, Masato Katahira
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 24巻 Issue: 2 Pages: 284-289
- DOI
  10.1016/j.bbrc.2012.07.083
- NAID
  120004873605
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22570116, KAKENHI-PROJECT-23390110, KAKENHI-PROJECT-23570146, KAKENHI-PROJECT-24390115, KAKENHI-PUBLICLY-24113710, KAKENHI-PLANNED-24115004, KAKENHI-PUBLICLY-24121714
[Journal Article] An automated system designed for large scale NMR data deposition and annotation : Application to over 600 assigned chemical shift data entries to the BioMagResBank from the RIKEN Structural Genomics/Proteomics Initiative internal database2012
- Author(s)
  Naohiro Kobayashi, Yoko Harano, Naoya Tochio, Eiichi Nakatani, Takanori Kigawa, Shigeyuki Yokoyama, Steven Mading, Eldon L. Ulrich, John L. Markley, Hideo Akutsu and Toshimichi Fujiwara
- Journal Title
  
  J. Biomol. NMR
  
  Volume: 53巻 Issue: 4 Pages: 311-320
- DOI
  10.1007/s10858-012-9641-6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22570116
[Journal Article] Solution structure of the Splicing Factor Motif (SFM) of the human Prp18 protein2012
- Author(s)
  He, F., Inoue, M., Kigawa, T., Takahashi, M., Kuwasako, K., Tsuda, K., Kobayashi, N., Terada, T., Shirouzu, M., Tanaka, A., Sugano, S., Guntert, P., Yokoyama, S., Muto, Y.
- Journal Title
  
  Proteins
  
  Volume: 80 Issue: 3 Pages: 968-974
- DOI
  10.1002/prot.24003
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21370045, KAKENHI-PROJECT-22570116, KAKENHI-PROJECT-23370080, KAKENHI-PROJECT-23570217, KAKENHI-PUBLICLY-23112723
[Journal Article] Structural basis for the dual RNA-recognition modes of human Tra2-β RRM2011
- Author(s)
  Tsuda, K., Someya, T., Kuwasako, K., Takahashi, M., Fahu, H., Inoue, M., Harada, T., Watanabe, S., Terada, T., Kobayashi, N., Shirouzu, M., Kigawa, T., Tanaka, A., Sugano, S., Guntert, P., Yokoyama, S., Muto, Y.
- Journal Title
  
  Nucl.Acids Res.
  
  Volume: 39(4) Issue: 4 Pages: 1538-1553
- DOI
  10.1093/nar/gkq854
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21370045, KAKENHI-PROJECT-22570116, KAKENHI-PROJECT-23570145
[Journal Article] The NMR structure of FliK, the trigger for the switch of substrate specificity in the flagellar type III secretion appratus2011
- Author(s)
  S.Mizuno, H.Amida, N.Kobayashi, S.Aizawa, S.Tate
- Journal Title
  
  J.Mol.Biol.
  
  Volume: 409 Issue: 4 Pages: 558-573
- DOI
  10.1016/j.jmb.2011.04.008
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-22018021, KAKENHI-PROJECT-22570116, KAKENHI-PUBLICLY-23107724, KAKENHI-PROJECT-23659024
[Presentation] Structural differences and Novel Polymorphs of Synthetic and brain-derived Aβ42 Fibrils by1H-detected SSNMR2020
- Author(s)
  A. Wickramasinghe, Y. Xiao, N. Kobayashi, T. Yamazaki and Y. Ishii
- Organizer
  第59回NMR討論会
- Data Source
  KAKENHI-PROJECT-18K06152
[Presentation] 多次元固体 MAS-NMR を用いたヘリオロドプシンの立体構造解析2020
- Author(s)
  鈴木しぶき，長島敏雄, 金子莉奈, 沖津貴志, 和田昭盛, 小林直宏, 山崎俊夫, 井上圭一, 神取秀樹, 川村出
- Organizer
  第59回NMR討論会
- Data Source
  KAKENHI-PROJECT-18K06152
[Presentation] 高速・高精度な MagRO による NMR 構造解析の完全自動化2020
- Author(s)
  小林直宏，杉木俊彦，南慎太朗，佐久間航也，長島敏雄，児嶋長次郎，藤原敏道，小杉貴洋，古賀理恵，古賀信康，山崎俊夫
- Organizer
  第59回NMR討論会
- Data Source
  KAKENHI-PROJECT-18K06152
[Presentation] Exploration of novel αβ protein folds by de novo design2020
- Author(s)
  南慎太郎、小林直宏、杉木俊彦、鈴木かの、千見寺浄慈、古賀理恵、古賀信康
- Organizer
  64th BioPhysical Society Annual Meeting, SanDiego
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06152
[Presentation] ヒト脂質輸送蛋白質CERがクラミジア封入体の膜蛋白Incにハイジャックされる分子機序の溶NMR解析2020
- Author(s)
  杉木俊彦，熊谷圭悟，新家粧子，小林直宏，藤原敏道，花田賢太郎，児嶋長次郎
- Organizer
  第59回NMR討論会
- Data Source
  KAKENHI-PROJECT-18K06152
[Presentation] Design of Globin-like Complicated Folds2020
- Author(s)
  佐久間航也、小林直宏、杉木俊彦、鈴木かの、小林直也、小杉貴洋、村田武士、古賀理恵、古賀信康
- Organizer
  64th BioPhysical Society Annual Meeting, SanDiego
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06152
[Presentation] 生体系NMRの最前線基礎から学ぶー構造解析自動化2020
- Author(s)
  小林直宏
- Organizer
  令和２年蛋白研セミナー
- Invited
- Data Source
  KAKENHI-PROJECT-18K06152
[Presentation] Nearly complete assignments for 23kDa membrane protein by solid-state NMR using MagRO system assisted by Graph_Robot based on finite automaton theory.2019
- Author(s)
  小林直宏、長嶋敏夫、山崎俊夫
- Organizer
  第58回NMR討論会
- Data Source
  KAKENHI-PROJECT-18K06152
[Presentation] Structural characterization of Aβ(1-42) fi brils in nano-mole scale by 1H-detected SSNMR under UFMASStructural characterization of Aβ(1-42) fi brils in nano-mole scale by 1H-detected SSNMR under UFMAS2019
- Author(s)
  Ayesha Wickramasinghe, Yiling Xiao、小林直宏、石井佳誉
- Organizer
  第58回NMR討論会
- Data Source
  KAKENHI-PROJECT-18K06152
[Presentation] Application of Deep Neural Networks for Highly Accurate NMR Structure Analysis by Deep-MagRO2018
- Author(s)
  Naohiro Kobayashi, Toshihiko Sugiki, Yoshikazu Hattori, Takashi Nagata, Shoko Shinya, Julia M. Wuerz, Rie Koga, Nobuyasu Koga, Peter Guentert, Chojiro Kojima and Toshimichi Fujiwara
- Organizer
  ICMRBS2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06152
[Presentation] Deep-MagRO: 深層学習を応用した高速かつ高精度な統合的NMR解析システム2018
- Author(s)
  小林直宏、杉木俊彦、永田崇、Peter Guentert, 児嶋長次郎、藤原敏道
- Organizer
  第57回NMR討論会
- Data Source
  KAKENHI-PROJECT-18K06152
[Presentation] Highly automated NMR signal assignments using peak-noise recognition assisted by Deep Neural Networks2017
- Author(s)
  N. Kobayashi, T. Nagata , C. Kojima and T. Fujiwara
- Organizer
  Gordon Research Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K06970
[Presentation] 人工知能世代のNMRデータベースと解析2017
- Author(s)
  小林直宏
- Organizer
  第17回日本蛋白質科学会年会
- Invited
- Data Source
  KAKENHI-PROJECT-15K06970
[Presentation] 深層学習により強化されたNMR立体構造解析2017
- Author(s)
  小林直宏、永田崇、服部良一、新家粧子、J.M. Wurz, P. Guntert、児嶋長次郎、藤原敏道
- Organizer
  第56回NMR討論会
- Data Source
  KAKENHI-PROJECT-15K06970
[Presentation] 統合化されたNMRデータベースの蛋白質研究への有効利用2016
- Author(s)
  小林直宏
- Organizer
  第16回日本蛋白質科学会年会
- Place of Presentation
  福岡国際会議場(福岡県、福岡市)
- Year and Date
  2016-06-07
- Invited
- Data Source
  KAKENHI-PROJECT-15K06970
[Presentation] New generation of NMR analysis assisted by Deep Learning and highly sophisticated Web-tools developed by PDBj-BMRB2016
- Author(s)
  小林直宏
- Organizer
  第54回生物物理学会年会
- Place of Presentation
  つくば国際会議場(茨城県、つくば市)
- Year and Date
  2016-11-25
- Invited
- Data Source
  KAKENHI-PROJECT-15K06970
[Presentation] 深層学習に支援されたNMRシグナルの自動解析2016
- Author(s)
  小林直宏、服部良一、永田崇、児嶋長次郎、藤原敏道
- Organizer
  第55回NMR討論会
- Place of Presentation
  広島国際会議場(広島県、広島市)
- Year and Date
  2016-11-16
- Data Source
  KAKENHI-PROJECT-15K06970
[Presentation] 高度化された生体高分子NMRデータベース2016
- Author(s)
  小林直宏、横地政史、岩田武史、児嶋長次郎、藤原敏道
- Organizer
  トーゴーの日シンポジウム2016
- Place of Presentation
  東京大学弥生講堂(東京都、文京区)
- Year and Date
  2016-10-05
- Data Source
  KAKENHI-PROJECT-15K06970
[Presentation] New library system in MagRO for automated analysis of NMR data on biomacromolecules2016
- Author(s)
  N. Kobayashi, M. Yokochi, T. Iwata , J.L. Markley , E.L. Ulrich ,E. Schmidtc , P. Guntertc, Y. Hattori, C. Kojima and T. Fujiwara
- Organizer
  ICMRBS 2016
- Place of Presentation
  国立京都国際会館（京都府、左京区)
- Year and Date
  2016-08-21
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K06970
[Presentation] New strategy for high-throughput NMR analysis using the NMR database BMRB and tools for automated NMR analysis, MagRO, FLYA and CYANA2015
- Author(s)
  Naohiro Kobayashi, Masashi Yokochi, Takeshi Iwata, Bikash Ranjan Sahoo, Takashi Nagata, John L. Markley, Eldon L. Ulrich, Elena Schmidt, Peter Guentert, Chojiro Kojima and Toshimichi Fujiwara
- Organizer
  International Society of Magnetic Resonance 2016
- Place of Presentation
  CELAP, Shanghai, China
- Year and Date
  2015-08-16
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K06970
[Presentation] NMRデータベースBioMagResBankの統合的拡張と公開2015
- Author(s)
  小林直宏、横地政史、岩田武史、本野千恵、廣明秀一、児嶋長次郎、藤原敏道
- Organizer
  第54回NMR討論会
- Place of Presentation
  千葉工業大学, 千葉県習志野市
- Year and Date
  2015-11-06
- Data Source
  KAKENHI-PROJECT-15K06970
[Presentation]2013
- Author(s)
  Naohiro Kobayashi
- Organizer
  International Conference on Structural Genomics 2013
- Place of Presentation
  札幌市
- Year and Date
  2013-07-29
- Data Source
  KAKENHI-PROJECT-22570116
[Presentation]2013
- Author(s)
  永田崇,白川貴恵,小林直宏,始平堂弘和,片平正人,堀澤健一,土居信英,柳川弘志
- Organizer
  第52回NMR討論会
- Place of Presentation
  金沢市
- Year and Date
  2013-11-12
- Data Source
  KAKENHI-PROJECT-22570116
[Presentation] IVV法により取得した高選択的MDM2結合ペプチドによる MDM2: p53結合阻害の構造基盤2013
- Author(s)
  永田　崇，白川貴恵，小林直宏，始平堂弘和，片平正人，堀澤健一，土居信英，柳川弘志
- Organizer
  第52回NMR討論会
- Place of Presentation
  金沢市
- Data Source
  KAKENHI-PROJECT-22570116
[Presentation] Multi-site binding of high affinity aptamer against AML1 Runt domain2013
- Author(s)
  天野亮,野村祐介,永田崇,小林直宏,森瑶子,福永淳一,田中陽一郎,片平正人,中村義一,神津知子,坂本泰一
- Organizer
  第40回国際核酸化学シンポジウム
- Place of Presentation
  横浜市
- Year and Date
  2013-12-03
- Data Source
  KAKENHI-PROJECT-22570116
[Presentation] 転写因子AML1に対して複数の結合部位を持つ高親和性RNAアプタマーの解析2013
- Author(s)
  天野亮,野村祐介,永田崇,小林直宏,森瑶子,福永淳一,田中陽一郎,片平正人,中村義一,神津知子,坂本泰一
- Organizer
  第36回日本分子生物学会年会
- Place of Presentation
  神戸市
- Year and Date
  2013-12-06
- Data Source
  KAKENHI-PROJECT-22570116
[Presentation] 仮想化技術を活用した生体高分子の解析研究のすすめ2012
- Author(s)
  小林直宏
- Organizer
  第12回蛋白質科学会年会
- Place of Presentation
  名古屋市
- Invited
- Data Source
  KAKENHI-PROJECT-22570116
[Presentation] 化学シフトデータベースを利用した高精度なNMR構造評価システム2012
- Author(s)
  小林直宏
- Organizer
  第51回NMR討論会
- Place of Presentation
  名古屋市
- Year and Date
  2012-11-09
- Data Source
  KAKENHI-PROJECT-22570116
[Presentation] 仮想化技術を用いたNMRデータの統合的解析環境2012
- Author(s)
  小林直宏
- Organizer
  第50回日本生物物理学会年会
- Place of Presentation
  名古屋市
- Year and Date
  2012-09-23
- Data Source
  KAKENHI-PROJECT-22570116
[Presentation] 仮想化技術による生体高分子NMR解析環境およびBMRBデータベースサーバーの統合化2012
- Author(s)
  小林直宏
- Organizer
  トーゴーの日シンポジウム2012
- Place of Presentation
  東京
- Invited
- Data Source
  KAKENHI-PROJECT-22570116
[Presentation] MagRO-Assign : A Tool for Automated Sequence Specific Assignment of Chemical Shifts for NMR Signals of Protein Backbone2011
- Author(s)
  Noahiro Kobayashi
- Organizer
  EUROMAE2011
- Place of Presentation
  フランクフルト(ドイツ)
- Year and Date
  2011-08-23
- Data Source
  KAKENHI-PROJECT-22570116
[Presentation] New server systems based on virtual computing for the database BMRB and MagRO-Tools for NMR analysis2011
- Author(s)
  Noahiro Kobayashi
- Organizer
  第50回NMR討論会記念国際シンポジウムISMAR2011
- Place of Presentation
  横浜
- Year and Date
  2011-11-16
- Data Source
  KAKENHI-PROJECT-22570116
[Presentation] New server systems based on virtual computing for the database BMRB and MagRO-Tools for NMR analysis2011
- Author(s)
  Naohiro Kobayashi, Takeshi Iwata, Yoko Harano, Chojiro Kojima, Haruki Nakamura, Toshimichi Fujiwara
- Organizer
  第50回記念NMR討論会国際シンポジウム
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-22570116
[Presentation] MagRO-Assign : a tool for automated sequence specific assignment of chemical shifts for NMR signals of protein backbone2011
- Author(s)
  Naohiro Kobayashi, Ayako Furukawa, Soichiro Kitazawa, Takashi Nagata, Ryo Kitahara, Masato Katahira and Toshimichi Fujiwara
- Organizer
  EUROMAR2011
- Place of Presentation
  Frankfurt (Germany)
- Data Source
  KAKENHI-PROJECT-22570116
[Presentation] NMRデータと構造アンサンブル、解析手法の基礎と応用2011
- Author(s)
  小林直宏
- Organizer
  新学術領域研究「天然変性タンパク質の分子認識と機能発現」第二回若手育成講習会
- Place of Presentation
  大阪大学蛋白質研究所(大阪)(招待講演)
- Year and Date
  2011-04-26
- Data Source
  KAKENHI-PROJECT-22570116
[Presentation] A molecular viewer and tools for analysis and validation of NMR data and structure ensembles2010
- Author(s)
  Naohiro Kobayashi
- Organizer
  XXIVth International Conference on Magnetic Resonance in Biological Systems (ICMRBS)
- Place of Presentation
  Cairns convention centre (Australia)
- Year and Date
  2010-08-26
- Data Source
  KAKENHI-PROJECT-22570116
[Presentation] 新しいデータ構造、データ評価法、自動解析技術によるNMR解析ツール群の開発2010
- Author(s)
  小林直宏
- Organizer
  蛋白研セミナー「実験と計算機科学で解明する蛋白質機能構造」
- Place of Presentation
  大阪大学蛋白質研究所(大阪)(招待講演)
- Year and Date
  2010-07-29
- Data Source
  KAKENHI-PROJECT-22570116
[Presentation] オントロジー工学を利用したNMRデータ解析、評価およびデータベース登録を支援するツール、MagROシステムの開発2010
- Author(s)
  小林直宏
- Organizer
  第49回NMR討論会
- Place of Presentation
  タワーホール船堀(東京)
- Year and Date
  2010-11-17
- Data Source
  KAKENHI-PROJECT-22570116

1. Kojima Chojiro (50333563)

# of Collaborated Projects: 3 results

# of Collaborated Products: 14 results
2. HIROAKI Hidekazu (10336589)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
3. MOTONO Chie (80415752)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
4. SUGIKI Toshihiko (70635698)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. FURUITA Kyoko (30727665)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 石井佳誉 (40799045)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 小沼剛 (10631682)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 寺山慧 (50789328)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. NAGATA Takashi

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results
10. PETER Guentert

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 下村拓史

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 片平正人

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 楯真一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Kobayashi Naohiro 小林 直宏

小林 直宏 コバヤシ ナオヒロ

KOBAYASHI Naohiro 小林 直宏

Research Projects

Research Products

Co-Researchers

機械学習・理論計算・実測データを活用した生体高分子の動的状態を可視化する新規技術Principal Investigator

Principal Investigator

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超高分解能固体NMRと自動解析による非結晶性生体高分子と先端材料構造解析の新機軸

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Development of fully automated NMR data analysis assisted by AIPrincipal Investigator

Principal Investigator

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Review Section

Research Institution

NMR Molecular Replacement Method

Principal Investigator

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Development of NMR drug discovery pipeline using databasePrincipal Investigator

Principal Investigator

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Automated NMR signal assignment with self-learning system efficently using databasePrincipal Investigator

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フラグメント間相互作用を利用した蛋白質立体構造形成機構の研究Principal Investigator

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合成ペプチドによる蛋白質立体構造形成過程の研究Principal Investigator

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Research Institution

[Journal Article] Mechanism of hERG inhibition by gating-modifier toxin, APETx1, deduced by functional characterization2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Robust folding of a de novo designed ideal protein even with most of the core mutated to valine.2020

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DOI

NAID

Data Source

[Journal Article] Crystal contact-free conformation of an intrinsically flexible loop in protein crystal: Tim21 as the case study2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Nucleus Accumbens-Associated Protein 1 Binds DNA Directly through the BEN Domain in a Sequence-Specific Manner2020

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DOI

Data Source

[Journal Article] Solution structure of Gaussia Luciferase with five disulfide bonds and identification of a putative coelenterazine binding cavity by heteronuclear NMR.2020

Author(s)

Journal Title

DOI

Data Source

Kobayashi Naohiro 小林直宏

小林直宏コバヤシナオヒロ

KOBAYASHI Naohiro 小林直宏