HIROISHI Kazumasa 廣石和正

Researcher Number	80296996
Other IDs
Affiliation (based on the past Project Information) *help	2009 – 2011: Showa University, 医学部, 准教授 2007 – 2008: Showa University, 医学部, 講師 2003 – 2004: 昭和大学, 医学部, 講師 2002: 昭和大学, 医学部, 助手
Review Section/Research Field	Principal Investigator Gastroenterology / Gastroenterology Except Principal Investigator Gastroenterology
Keywords	Principal Investigator 免疫療法 / 樹状細胞 / interleukin-12 / interleukin-4 / hybrid / gastrointestinal cancer / immunotherapy / dendritic cell / interferon-alpha / gene therapy … More / インターフェロンα / インターロイキン-12 / インターロイキン-4 / 融合細胞 / 消化器癌 / インターフェロン-α / 遺伝子治療 / 細胞傷害性T細胞 / C型肝炎 / 肝細胞癌 / FLT-3リガンド / TNF / インターロイキン / 大腸癌 / 免疫治療 / 腫瘍免疫 / 抗腫瘍効果 / インターフェロン / ナチュラルキラー細胞 … More Except Principal Investigator HLA-A24 / epitope / interferon / cytotoxic T cell / hepatitis C virus / エピトープ / インターフェロン / 細胞障害性T細胞 / C型肝炎ウイルス Less

C型肝炎・肝癌の新規ワクチン療法を目指した細胞障害性T細胞エピトープの網羅的解析Principal Investigator
- Principal Investigator
  
  廣石和正
- Project Period (FY)
  2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Showa University
Interferon-producing killer dendritic cell-based immunotherapy for gastrointestinal cancerPrincipal Investigator
- Principal Investigator
  
  HIROISHI Kazumasa
- Project Period (FY)
  2007 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Showa University
Research on cytotoxic T cell responses to hepatitis C virus infection
- Principal Investigator
  
  IMAWARI Michio
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Gastroenterology
- Research Institution
  Showa University
  Jichi Medical University
Anticancer therapy by hybrids of dendritic cells and interferon-α-overexpressing cellsPrincipal Investigator
- Principal Investigator
  
  HIROISHI Kazumasa
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Showa University

All 2010 2009 2008 2007 2005 2003 2002

All Journal Article Presentation

[Journal Article] Immune response of cytotoxic T lymphocytes and possibility of vaccine development for hepatitis C virus infection.2010
- Author(s)
  Hiroishi, K., Eguchi, J., Ishii, S., 他5名
- Journal Title
  
  Journal of Biomedicine and Biotechnology
  
  Volume: 2010 Pages: 263810-263810
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590738
[Journal Article] Strong CD8+ T-cell responses against tumor-associated antigens prolong the recurrence-free interval after tumor treatment in patients with hepatocellular carcinoma.2010
- Author(s)
  Hiroishi K., Eguchi J., Baba T., Shimazaki T., Ishii S., Hiraide A., Sakaki M., Doi H., Uozumi S., Omori R., Matsumura T., Yanagawa T., Ito T., Imawari M
- Journal Title
  
  J Gastroenterol 45(4)
  
  Pages: 451-458
- NAID
  10027215796
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590738
[Journal Article] Strong CD8+ T-cell responses against tumor-associated antigens prolong the recurrence-free interval after tumor treatment in patients with HCC.2010
- Author(s)
  Hiroishi, K., Eguchi, J., Baba, T., 他11名
- Journal Title
  
  Journal of Gastroenterology
  
  Volume: 45 Pages: 451-458
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590738
[Journal Article] Cyclooxygenase-2 gene promoter haplotypes affect susceptibility to hepatitis C virus infection and disease progression.2010
- Author(s)
  Sakaki, M., Makino, R., Hiroishi, K., 他6名
- Journal Title
  
  Hepatology Research
  
  Volume: 40 Pages: 1219-1226
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590738
[Journal Article] Immune response of cytotoxic T lymphocytes and possibility of vaccine development for hepatitis C virus infection.2010
- Author(s)
  Hiroishi K., Eguchi J., Ishii S., Hiraide A., Sakaki M., Doi H., Omori R., Imawari M.
- Journal Title
  
  J Biomed and Biotech 2010
  
  Pages: 263810-263810
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590738
[Journal Article] Infection of B cells with hepatitis C virus for the development of lymphoproliferative disorders in patients with chronic hepatitis C2009
- Author(s)
  Inokuchi M, Ito T, Uchikoshi M, Shimozuma Y, Morikawa K, Nozawa H, Shimazaki T, Hiroishi K, Miyakawa Y, Imawari M.
- Journal Title
  
  Journal of Medical Virology 81
  
  Pages: 619-627
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590738
[Journal Article] Magnitude of CD8+ T-cell responses against hepatitis C virus and severity of hepatitis do not necessarily determine outcomes in acute hepatitis C virus infection2009
- Author(s)
  Doi H, Hiroishi K, Shimazaki T, Eguchi J, Baba T, Ito T, Matsumura T, Nozawa H, Morikawa K, Ishii S, Hiraide A, Sakaki M, Imawari M.
- Journal Title
  
  Hepatology Research 33
  
  Pages: 256-265
- NAID
  10025324889
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590738
[Journal Article] Dendritic cells stimulated with CpG oligodeoxynucleotides and IFN-alpha -expressing tumor cells effectively reduce outgrowth of established tumors in vivo.2008
- Author(s)
  Hiraide A., Hiroishi K., Ishii S., Eguchi J., Imawari M.
- Journal Title
  
  Cancer Sci 99(8)
  
  Pages: 1663-1669
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590738
[Journal Article] Dendritic cells stimulated with CpG oligodeoxynucleotides and IFN-alpha-expressing tumor cells effectively reduce outgrowth of established tumors in vivo.2008
- Author(s)
  Hiraide A, Hiroishi K, Eguchi J, Ishii S, Doi H, Imawari M
- Journal Title
  
  99
  
  Pages: 1663-1669
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590738
[Journal Article] Interleukin-4 gene transduced tumor cells promote a potent tumor-specific Th-1 type response in cooperation with interferon-alpha transduction.2005
- Author(s)
  Eguchi J, Hiroishi K, Ishii S, Baba T, Matsumura T, Hiraide A, Okada H, Imawari M
- Journal Title
  
  Gene Ther.
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14570509
[Journal Article] Dendritic cell maturation induced by delivery of ultraviolet-mediated apoptotic colorectal cancer cell lines.2003
- Author(s)
  Ishii S, Hiroishi K, Eguchi J, Mitamura K
- Journal Title
  
  Anticancer Res 23(3B)
  
  Pages: 2457-2463
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14570509
[Journal Article] Interferon-alpha and interleukin-12 gene therapy of cancer : interferon-alpha induces tumor-specific immune responses while interleukin-12 stimulates non-specific killing.2003
- Author(s)
  Eguchi J, Hiroishi K, Ishii S, Mitamura K
- Journal Title
  
  Cancer Immunol Immunother 52
  
  Pages: 378-386
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14570509
[Journal Article] Differential effect of cytotoxic T lymphocyte variant epitopes on generation and cytotoxicity in chronic hepatitis C virus infection2002
- Author(s)
  Hiroishi K
- Journal Title
  
  Hepatology Research 24
  
  Pages: 91-94
- NAID
  50000654883
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14370190
[Journal Article] Murine dendritic cell-induced tumor apoptosis is partially mediated by nitric oxide2002
- Author(s)
  Shimamura H, Cumberland R, Hiroishi K, Watkins SC, Lotze MT, Baar J
- Journal Title
  
  J Immunother 25
  
  Pages: 226-234
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14570509
[Presentation] 消化器癌におけるIL-4とCpG併用による抗腫瘍効果と作用機序の検討2010
- Author(s)
  江口潤一、広石和正、土肥弘義、石井成明、平出綾子、坂木理、大森里紗、馬場俊之、松村卓哉、魚住祥二郎、井廻道夫
- Organizer
  第52回日本消化器病学会大会
- Place of Presentation
  横浜
- Year and Date
  2010-10-13
- Data Source
  KAKENHI-PROJECT-19590738
[Presentation] インターロイキン-4とCpGを用いた消化器癌に対する免疫療法の検討2009
- Author(s)
  土肥弘義、広石和正、江口潤一、石井成明、平出綾子、坂木理、井廻道夫
- Organizer
  第95回日本消化器病学会総会
- Place of Presentation
  札幌
- Year and Date
  2009-05-09
- Data Source
  KAKENHI-PROJECT-19590738
[Presentation] 樹状細胞とインターフェロンα、CpG併用療法による抗腫瘍効果の作用機序2008
- Author(s)
  広石和正、平出綾子、江口潤一、坂木理、土肥弘義、井廻道夫
- Organizer
  第94回日本消化器病学会総会
- Place of Presentation
  福岡
- Year and Date
  2008-05-10
- Data Source
  KAKENHI-PROJECT-19590738
[Presentation] 樹状細胞とインターフェロンα、CpG併用療法による抗腫瘍効果の作用機序.2008
- Author(s)
  廣石和正, 平出綾子, 江口潤一, 坂木理, 土肥弘義, 井廻道夫
- Organizer
  第94回日本消化器病学会総会
- Place of Presentation
  福岡
- Year and Date
  2008-05-10
- Data Source
  KAKENHI-PROJECT-19590738
[Presentation] Efficacy and mechanism of dendritic cell-based immunotherapy with CpG and IFN-alpha-expressing tumor cells for murine colorectal cancer2008
- Author(s)
  Doi H, Hiroishi K, Hiraide A, Eguchi J, Ishii S, Matsumura T, Sakaki M, Imawari M.
- Organizer
  2008 American Association of Cancer Research 99th Annual Meeting
- Place of Presentation
  SanDiego, USA
- Year and Date
  2008-04-14
- Data Source
  KAKENHI-PROJECT-19590738
[Presentation] Efficacy and mechanism of dendritic cell-based immunotherapy with CpG and IFN-alpha-expressing tumor cells for murine colorectal cancer.2008
- Author(s)
  Doi H., Hiroishi K., Eguchi J., Baba T., Ishii S., Hiraide A., Sakaki M., Imawari M.
- Organizer
  2008 American Association of Cancer Research 99^<th> Annual Meeting
- Place of Presentation
  San Diego, USA
- Year and Date
  2008-04-14
- Data Source
  KAKENHI-PROJECT-19590738
[Presentation] Efficacy and mechanism of dendritic cell-based immunotherapy with CpG and IFN-alpha-expressing tumor cells for murine colorectal cancer.2008
- Author(s)
  Doi H, Hiroishi K, Hiraide A, Eguchi J, Ishii S, Matsumura T, Sakaki M, Imawari M
- Organizer
  2008 American Association of Cancer Research 99th Annual Meeting
- Place of Presentation
  San Diego, USA.
- Year and Date
  2008-04-14
- Data Source
  KAKENHI-PROJECT-19590738
[Presentation] IFN-α遺伝子導入癌細胞と樹状細胞との融合細胞による抗腫瘍免疫誘導作用の検討.2007
- Author(s)
  廣石和正, 井廻道夫
- Organizer
  第49回日本消化器病学会大会
- Place of Presentation
  神戸
- Year and Date
  2007-10-19
- Data Source
  KAKENHI-PROJECT-19590738
[Presentation] IFN-α遺伝子導入癌細胞と樹状細胞との融合細胞による抗腫瘍免疫誘導作用の検討2007
- Author(s)
  広石和正、平出綾子、江口潤一、土肥弘義、井廻道夫
- Organizer
  第49回日本消化器病学会大会
- Place of Presentation
  神戸
- Year and Date
  2007-10-19
- Data Source
  KAKENHI-PROJECT-19590738
[Presentation] インターフェロンα遺伝子導入癌細胞と樹状細胞との融合細胞による消化器癌治療2007
- Author(s)
  平出綾子、広石和正、土肥弘義、江口潤一、井廻道夫
- Organizer
  第93回日本消化器病学会総会
- Place of Presentation
  青森
- Year and Date
  2007-04-19
- Data Source
  KAKENHI-PROJECT-19590738
[Presentation] IL-4 transfected tumor cell vaccines activate tumor infiltrating dendritic cells and promote Type-1 immunity.2007
- Author(s)
  Eguchi J., Hiroishi K., Hiraide A., Doi H., Ishii S., Okada H., Imawari M.
- Organizer
  第66回日本癌学会学術総会
- Place of Presentation
  横浜
- Year and Date
  2007-10-04
- Data Source
  KAKENHI-PROJECT-19590738

1. 江口潤一 (00384371)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. IMAWARI Michio (70134228)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. ITO Takayoshi (50317517)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. NAKAMURA Ikuo (40251243)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

HIROISHI Kazumasa 廣石 和正

Research Projects

Research Products

Co-Researchers

C型肝炎・肝癌の新規ワクチン療法を目指した細胞障害性T細胞エピトープの網羅的解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Interferon-producing killer dendritic cell-based immunotherapy for gastrointestinal cancerPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Research on cytotoxic T cell responses to hepatitis C virus infection

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Anticancer therapy by hybrids of dendritic cells and interferon-α-overexpressing cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Immune response of cytotoxic T lymphocytes and possibility of vaccine development for hepatitis C virus infection.2010

Author(s)

Journal Title

Data Source

[Journal Article] Strong CD8+ T-cell responses against tumor-associated antigens prolong the recurrence-free interval after tumor treatment in patients with hepatocellular carcinoma.2010

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Strong CD8+ T-cell responses against tumor-associated antigens prolong the recurrence-free interval after tumor treatment in patients with HCC.2010

Author(s)

Journal Title

Data Source

[Journal Article] Cyclooxygenase-2 gene promoter haplotypes affect susceptibility to hepatitis C virus infection and disease progression.2010

Author(s)

Journal Title

Data Source

[Journal Article] Immune response of cytotoxic T lymphocytes and possibility of vaccine development for hepatitis C virus infection.2010

Author(s)

Journal Title

Data Source

[Journal Article] Infection of B cells with hepatitis C virus for the development of lymphoproliferative disorders in patients with chronic hepatitis C2009

Author(s)

Journal Title

Data Source

[Journal Article] Magnitude of CD8+ T-cell responses against hepatitis C virus and severity of hepatitis do not necessarily determine outcomes in acute hepatitis C virus infection2009

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Dendritic cells stimulated with CpG oligodeoxynucleotides and IFN-alpha -expressing tumor cells effectively reduce outgrowth of established tumors in vivo.2008

Author(s)

Journal Title

Data Source

[Journal Article] Dendritic cells stimulated with CpG oligodeoxynucleotides and IFN-alpha-expressing tumor cells effectively reduce outgrowth of established tumors in vivo.2008

Author(s)

Journal Title

Data Source

[Journal Article] Interleukin-4 gene transduced tumor cells promote a potent tumor-specific Th-1 type response in cooperation with interferon-alpha transduction.2005

Author(s)

Journal Title

Description

Data Source

[Journal Article] Dendritic cell maturation induced by delivery of ultraviolet-mediated apoptotic colorectal cancer cell lines.2003

Author(s)

Journal Title

Description

Data Source

[Journal Article] Interferon-alpha and interleukin-12 gene therapy of cancer : interferon-alpha induces tumor-specific immune responses while interleukin-12 stimulates non-specific killing.2003

Author(s)

Journal Title

Description

HIROISHI Kazumasa 廣石和正