Sankai Tadashi 山海直

… Alternative Names

SANKAI Tadashi 山海直

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Researcher Number	80300937
Other IDs
Affiliation (Current)	2025: 国立研究開発法人医薬基盤・健康・栄養研究所, 医薬基盤研究所霊長類医科学研究センター, 客員研究員
Affiliation (based on the past Project Information) *help	2019 – 2024: 国立研究開発法人医薬基盤・健康・栄養研究所, 医薬基盤研究所霊長類医科学研究センター, 再雇用職員 2015 – 2019: 国立研究開発法人医薬基盤・健康・栄養研究所, 医薬基盤研究所霊長類医科学研究センター, 主任研究員 2015: 国立研究開発法人医薬基盤・健康・栄養研究所, 霊長類医科学研究センター, 主任研究員 2010: (独)医薬基盤・霊長類医科学センター, 主任研究員 2010: (独)医薬基盤研霊長類医科学センター, 主任研究員 … More 2009: 独)医薬基盤研究所, 霊長類医科学センター, 主任研究員 2008: (独)医薬基盤研, 霊長類医科学センター, 主任研究員 2008: 独立行政法人医薬基盤研究所, 霊長類医科学研究センター, 主任研究員 2007: (独)医薬基盤研究所, 霊長類医科学センター, 主任研究員 2007: 独立行政法人医薬基盤研究所, 霊長類医科学研究センター, 主任研究官 2005: Tsukuba Primate Center for Medical Science, National Institute of Infectious Diseases, investigator, 霊長類医科学研究センター, 主任研究官 2004: 国立感染症研究所, 筑波医学実験用霊長類センター, 主任研究官 Less
Review Section/Research Field	Except Principal Investigator Basic Section 56040:Obstetrics and gynecology-related / Laboratory animal science / Medium-sized Section 42:Veterinary medical science, animal science, and related fields / Basic Section 42020:Veterinary medical science-related / Basic Section 56030:Urology-related / Basic Section 42040:Laboratory animal science-related / Basic Section 49010:Pathological biochemistry-related / Basic Section 57080:Social dentistry-related / Basic Section 57030:Conservative dentistry-related / Laboratory animal science / Laboratory animal science / Circulatory organs internal medicine
Keywords	Except Principal Investigator カニクイザル / ES細胞 / セルトリ細胞 / 免疫不全マウス / 生殖細胞移植 / 霊長類 / マーモセット / 歯周炎 / トランスレーショナルリサーチ / ウサギ … More / サル / 不妊 / 精子形成 / DTR / ノックインマウス / 精巣 / caspase 3 / ALS / TDP-43 / カニクイザル心停止ドナー子宮移植 / ピッグ自家子宮移植モデル / カニクイザル心停止ドナー子宮移植モデル / 動物実験モデル / 少子化対策 / 温阻血・冷阻血耐性 / 心停止ドナー / 子宮移植 / 凍結保存 / 高齢不妊 / Hippoシグナル / 低侵襲 / 卵胞活性化 / 卵巣機能不全 / 早発閉経 / 培養 / 遺伝子改変 / 発生工学 / 幹細胞 / 細胞分裂 / PIWIL4 / 生殖工学 / ウイルス / 遺伝子改変動物 / 移植前選抜 / ノックイン / 初期胚 / 精子幹細胞 / 生殖細胞 / 歯周炎治療 / FLT-1 / 3次元培養 / 歯周炎治療薬 / 三次元培養 / 初代培養 / 初代培養細胞 / VEGFR阻害剤 / コラーゲン分解 / シングルセルRNA-Seq / 歯周炎関連線維芽細胞 / 生体外歯周炎モデル / Porphyromonas macacae / カニクイサル / P. macacae / 診断 / 細菌 / micro RNA / 歯周炎関連細菌 / microRNA / エクソソーム / 歯垢細菌 / 実験的歯周炎 / 老齢マスス / 加齢 / 老齢マウス / パラビオシス / マウス / 核移植クローン / ゲノム可塑性 / ゲノム再プログラム化 / 難治性疾患 / ゲノム編集 / キメラ / ナイーブ変換 / iPS細胞 / chimera / germ cells / naive / iPS cells / ES cells / Experimental Animals / embryonic stem cell / monkey / primordial germ cell / embryonic germ cell / EG細胞(embroyonic germ cell) / サルES細胞 / 始原生殖細胞 / EG細胞(embryonic germ cell) / 血圧検査 / 超音波検査 / 胸部エックス線 / 心電図検査 / 臨床 / 循環器 / 循環器検査 / トキシコロジー / 心疾患 / ニホンザル / 獣医学 / 心臓病態学 / 多分化能 / ブタ / 実験動物 / ドナー細胞 / 再生医療 / クローン / 核移植 Less

Pathological and diagnostic significance of the N-terminal fragment of TDP-43 in ALS
- Principal Investigator
  
  守村敏史
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 42020:Veterinary medical science-related
- Research Institution
  Shiga University of Medical Science
若年がん男児の妊孕性温存を目指す前臨床研究：精巣凍結保存・移植による生殖能回復
- Principal Investigator
  
  本橋秀之
- Project Period (FY)
  2023 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56030:Urology-related
- Research Institution
  Tokyo Medical University
Basic research for the widespread use of non-heart-beating donor uterus transplantation (animal experimental model)
- Principal Investigator
  
  加藤容二郎
- Project Period (FY)
  2022 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56040:Obstetrics and gynecology-related
- Research Institution
  Showa University
Constructing primate testes in mice by replacing testicular cells
- Principal Investigator
  
  渡部聡朗
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Challenging Research (Pioneering)
- Review Section
  
  Medium-sized Section 42:Veterinary medical science, animal science, and related fields
- Research Institution
  National Center for Child Health and Development
A novel trial for periodontitis treatment by administering anti-FLT1 antibody to the naturally-occurred periodontitis-affected cynomolgus monkey gingiva
- Principal Investigator
  
  山口洋子
- Project Period (FY)
  2020 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49010:Pathological biochemistry-related
- Research Institution
  Nihon University
Development of novel techniques for generation of genome engineering marmosets
- Principal Investigator
  
  Watanabe Toshiaki
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 42040:Laboratory animal science-related
- Research Institution
  National Center for Child Health and Development
  Central Institute for Experimental Animals
Identification of periodontal pathogenic bacteria and elucidation of bacterial transmission pathway using cynomolgus monkey.
- Principal Investigator
  
  HIRAMINE HIROKO
- Project Period (FY)
  2019 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57080:Social dentistry-related
- Research Institution
  Kanagawa Dental College
Innovation of aging infertility treatment by developing a minimally invasive in vitro activation therapy
- Principal Investigator
  
  Kawamura Kazuhiro
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 56040:Obstetrics and gynecology-related
- Research Institution
  Juntendo University
  International University of Health and Welfare
Exploration of periodontitis-related molecules by using spontaneous periodontitis monkey
- Principal Investigator
  
  Komaki Motohiro
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57030:Conservative dentistry-related
- Research Institution
  Kanagawa Dental College
Establishment of heredital desease models using iPS cells and genome editing
- Principal Investigator
  
  Honda Arata
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Laboratory animal science
- Research Institution
  Kyoto University
  University of Miyazaki
Identification of factors endowing the genome with a high plasticity in the mouse and their applications to biomedical researches
- Principal Investigator
  
  Ogura Atsuo
- Project Period (FY)
  2011 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Research Field
  
  Laboratory animal science
- Research Institution
  Institute of Physical and Chemical Research
Establishment of nuclear transfer ES cells in non-rodent laboratory species
- Principal Investigator
  
  OGURA Atsuo
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Laboratory animal science
- Research Institution
  The Institute of Physical and Chemical Research
Cardiac and inheritance disease analysis in monkeys
- Principal Investigator
  
  KOIE Hiroshi
- Project Period (FY)
  2007 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Nihon University
Establishment of embryonic gem cells and their differentiation into germ cells.
- Principal Investigator
  
  TORII Ryuzo
- Project Period (FY)
  2002 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Laboratory animal science
- Research Institution
  Shiga University of medical science

All 2023 2022 2021 2019 2017 2010 2009 2008 2007

All Journal Article Presentation

[Journal Article] Ageing and chronic disease-related changes in the morphometric characteristics of ovarian follicles in cynomolgus monkeys (<i>Macaca fascicularis</i>)2021
- Author(s)
  Grin L、Vo K C T、Sato Y、Mizrachi Y、Kohara M、Sankai T、Kawamura K
- Journal Title
  
  Human Reproduction
  
  Volume: 36 Issue: 10 Pages: 2732-2742
- DOI
  10.1093/humrep/deab191
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H03801, KAKENHI-PROJECT-18K19624
[Journal Article] Discrimination of stem cell status after subjecting cynomolgus monkey pluripotent stem cells to naive conversion.2017
- Author(s)
  Honda A, Kawano Y, Izu H, Choijookhuu N, Honsho K, Nakamura T, Yabuta Y, Yamamoto T, Takashima Y, Hirose M, Sankai T, Hishikawa Y, Ogura A, Saitou M
- Journal Title
  
  Scientific Reports
  
  Volume: 7 Issue: 1 Pages: 45285-45285
- DOI
  10.1038/srep45285
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PLANNED-25112009, KAKENHI-PROJECT-16H02465, KAKENHI-PROJECT-15H04286, KAKENHI-PROJECT-16K08471, KAKENHI-PROJECT-16K15489, KAKENHI-ORGANIZER-25112001, KAKENHI-PROJECT-15K14887
[Journal Article] Simian betaretrovirus infection in a colony of cynomolgus monkeys(Macaca fascicularis)2010
- Author(s)
  Fujiomto K, Takano J, Narita T, Hanari K, Shimozawa N, Sankai T, Yosida T, Terao K, Kurata T, Yasutomi Y.
- Journal Title
  
  Comp.Med. 60(1)
  
  Pages: 51-53
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590834
[Journal Article] Simian betaretrovirus infection in a colony of cynomolgus monk eys (Macaca fascicularis)2010
- Author(s)
  Fujiomto K, Takano J, Narita T, Hanari K, Shimozawa N, Sankai T, Yosida T, Terao K, Kurata T, Yasutomi Y.
- Journal Title
  
  Comp.Med. 60 (1)
  
  Pages: 51-53
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590834
[Journal Article] Simian betaretrovir us infection in a colony of cynomolgus monk eys (Macaca fascicularis).2010
- Author(s)
  Fujiomto K, Takano J, Narita T, Hanari K, Shimozawa N, Sankai T, Yosida T, Terao K, Kurata T, Yasutomi Y
- Journal Title
  
  Comp.Med. 60(1)
  
  Pages: 51-53
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590834
[Journal Article] (Review) Reproductive Technologies and the related studies in cynomolgus monkey2008
- Author(s)
  Shimozawa N, Sankai T, Ogura A
- Journal Title
  
  Mamm Ova Res 25
  
  Pages: 133-142
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19300151
[Journal Article] Stable ES cell lines in rabbits - potential small animal models for human ES cell research2008
- Author(s)
  Honda A, Hirose M, Inoue K, Ogonuki N, Miki H, Shimozawa N, Hatori M, Shimizu N, Murata T, Hirose H, Katayama K, Wakisaka N, Miyoshi H, Yokoyama KK, Sankai T, Ogura A
- Journal Title
  
  Reprod Biomed Online 17
  
  Pages: 706-715
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19300151
[Journal Article] Transthyretin Amyloidosis and Two Other Aging-Related Amyloidoses in an Aged Vervet Monkey2008
- Author(s)
  Nakamura S, Okabayashi S, Ageyama N, Koie H, Sankai T, Ono F, Fujimoto K, Terao K.
- Journal Title
  
  Veterinary Pathology 45
  
  Pages: 67-72
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590834
[Journal Article] Transthyretin Amyloidosis and Two Other Aging-Related Amyloidoses in an Aged Vervet Monkey.2008
- Author(s)
  Nakamura S, Okabayashi S, Ageyama N, Koie H, Sankai T, Ono F, Fujimoto K, Terao K
- Journal Title
  
  Veterinary Pathology. 45
  
  Pages: 67-72
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590834
[Presentation] 昭和大学における子宮移植動物実験・トレーニングについて2023
- Author(s)
  加藤容二郎、吉武理、長島稔、島田佳苗、佐々木陽介、遠藤和洋、山海直、松本光司、矢持淑子、関沢明彦、青木武士
- Organizer
  第59回日本移植学会総会
- Data Source
  KAKENHI-PROJECT-22K09626
[Presentation] 各所属施設における子宮移植動物実験・トレーニングについて2022
- Author(s)
  加藤容二郎、吉武理、長島稔、三木克之、近藤晃、熊切順、小平賢介、清野雄介、中川雅史、山本智子、柴田亮行、遠藤和洋、山海直、松本光司、矢持淑子、関沢明彦、青木武士
- Organizer
  第48回日本臓器保存生物医学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-22K09626
[Presentation] 霊長類コモンマーモセット及びカニクイザルの雄性生殖細胞における DNA メチル化確立過程のシングルセル解析2022
- Author(s)
  小島一晃、近藤洋介、小原実穂、Dollet Constance、山海直、仲木竜、渡部聡朗
- Organizer
  日本実験動物学会
- Data Source
  KAKENHI-PROJECT-22K18356
[Presentation] 霊長類コモンマーモセット及びカニクイザルの雄性生殖細胞における DNA メチル化確立過程のシングルセル解析2022
- Author(s)
  小島一晃、近藤洋介、小原実穂、Dollet Constance、山海直、仲木竜、渡部聡朗
- Organizer
  日本実験動物学会
- Data Source
  KAKENHI-PROJECT-20H03177
[Presentation] 大規模繁殖コロニーのカニクイザルにおける歯周病実態調査2019
- Author(s)
  曽根崇晴、小牧基浩、山海直、平嶺浩子1、渡辺清子、浜田信城、児玉利朗
- Organizer
  第162回日本獣医学会学術集会
- Data Source
  KAKENHI-PROJECT-18K09586
[Presentation] 大規模繁殖コロニーのカニクイザルにおける歯周病実態調査2019
- Author(s)
  曽根崇晴，小牧基浩，山海直，平嶺浩子，渡辺清子，浜田信城，児玉利朗
- Organizer
  第162回日本獣医学会学術集会
- Data Source
  KAKENHI-PROJECT-19K10455
[Presentation] カニクイザルにおけるANP,BNP基準値の確立と臨床応用に関する研究2009
- Author(s)
  宝蔵寺璃恵、鯉江洋、金山喜一、酒井健夫、加藤美代子、寺尾恵治、山海直、揚山直英
- Organizer
  第36回日本トキシコロジー学会
- Place of Presentation
  アイーナ盛岡
- Year and Date
  2009-07-07
- Data Source
  KAKENHI-PROJECT-19590834
[Presentation] カニクイザルにおけるANP, BNP基準値の確立と臨床応用に関する研究2009
- Author(s)
  宝蔵寺璃恵, 鯉江洋, 金山喜一, 酒井健夫, 加藤美代子, 寺尾恵治, 山海直, 揚山直英
- Organizer
  第36回日本トキシコロジー学会
- Place of Presentation
  アイーナ盛岡
- Year and Date
  2009-07-07
- Data Source
  KAKENHI-PROJECT-19590834
[Presentation] ウサギES細胞の効率的な樹立とその維持2008
- Author(s)
  本多新, 廣瀬美智子, 井上貴美子, 越後貫成美, 三木洋美, 下澤律浩, 羽鳥真功, 清水なつみ, 村田武英, 廣瀬めぐみ, 形山和史, 脇阪紀子, 三好浩之, 横山和尚, 山海直, 小倉淳郎
- Organizer
  第3回ウサギフォーラム
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-19300151
[Presentation] カニクイザルにおける心エコー図評価基準の樹立2008
- Author(s)
  池田嘉孝、鯉江洋、金山喜一、酒井健夫、加藤美代子、寺尾恵治、山海直、揚山直英
- Organizer
  第55回日本実験動物学会
- Place of Presentation
  仙台国際センター
- Year and Date
  2008-05-16
- Data Source
  KAKENHI-PROJECT-19590834
[Presentation] ウサギES様細胞の樹立・培養の効率化と解析2007
- Author(s)
  本多新, 廣瀬美智子, 井上貴美子, 三木洋美, 越後貫成美, 小倉淳郎, 脇阪紀子, 下澤律浩, 羽鳥真功, 山海直
- Organizer
  第100回日本繁殖生物学会大会・第12回日本生殖内分泌学会学術集会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-19300151
[Presentation] Improvements in the derivation and culture of rabbit embryonic stem-like cells and their characterization in vitro and in vivo2007
- Author(s)
  Hirose M, Honda A, Inoue K, Ogonuki N, Miki H, Wakisaka N, Shimozawa N, Hatori M, Shimizu N, Katayama K, Miyoshi H, Sankai T, Ogura A
- Organizer
  4th Annual Conference of Asian Reproductive Biotechnology Society 2007 Singapore
- Place of Presentation
  Singapore
- Data Source
  KAKENHI-PROJECT-19300151
[Presentation] ウサギES様細胞の樹立と解析2007
- Author(s)
  廣瀬美智子, 本多新, 井上貴美子, 三木洋美, 越後貫成美, 脇阪紀子, 小倉淳郎, 下澤律浩, 羽鳥真功, 山海直
- Organizer
  第24回日本疾患モデル学会総会
- Place of Presentation
  つくば
- Data Source
  KAKENHI-PROJECT-19300151

1. OGURA Atsuo (20194524)

# of Collaborated Projects: 3 results

# of Collaborated Products: 7 results
2. Komaki Motohiro (30401368)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
3. HIRAMINE HIROKO (30386841)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
4. Watanabe Toshiaki (40715405)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
5. 児玉利朗 (20170269)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
6. KOIE Hiroshi (20267040)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
7. AGEYAMA Naohide (50399458)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
8. TORII Ryuzo (50106647)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. TSUCHIYA Hideaki (10378440)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. TAKADA Tatsuyuki (90206756)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. KIMURA Hiroshi (00110560)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. KUWANA Takashi (30145297)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. Honda Arata (10373367)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. MATSUDA Osamu (00271164)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. NAGAI Takashi (20391378)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. Kawamura Kazuhiro (10344756)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
17. 下島圭子 (30578935)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 阿部訓也 (40240915)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 石野史敏 (60159754)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 若菜茂晴 (90192434)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. 鎌田要平 (80385070)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. 浜田信城 (20247315)

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Sankai Tadashi 山海 直

SANKAI Tadashi 山海 直

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[Journal Article] Ageing and chronic disease-related changes in the morphometric characteristics of ovarian follicles in cynomolgus monkeys (<i>Macaca fascicularis</i>)2021

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Sankai Tadashi 山海直

SANKAI Tadashi 山海直