Kakizaki Ikuko 柿崎育子

… Alternative Names

KAKIZAKI Ikuko 柿崎育子

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Researcher Number	80302024
Other IDs	https://orcid.org/0000-0002-6702-5830
Affiliation (Current)	2025: 弘前大学, 医学研究科, 准教授
Affiliation (based on the past Project Information) *help	2016 – 2025: 弘前大学, 医学研究科, 准教授 2017: 弘前大学, 大学院医学研究科, 准教授 2011 – 2015: 弘前大学, 医学(系)研究科(研究院), 准教授 2012 – 2013: 弘前大学, 医学(系)研究科, 准教授 2012: 弘前大学, 医学( 系) 研究科( 研究院), 准教授 … More 2007 – 2011: 弘前大学, 大学院・医学研究科, 准教授 2004 – 2006: 弘前大学, 医学部, 助手 2003: 弘前大, 医学部, 助手 1999 – 2002: 弘前大学, 医学部, 助手 1999: 引前大学, 医学部, 助手 Less
Review Section/Research Field	Principal Investigator Functional biochemistry / Basic Section 56020:Orthopedics-related / Obstetrics and gynecology Except Principal Investigator Basic Section 56070:Plastic and reconstructive surgery-related / Basic Section 55020:Digestive surgery-related / Structural biochemistry / Obstetrics and gynecology / Functional biochemistry / General medical chemistry / Biomedical engineering/Biological material science / Structural biochemistry / Biological Sciences
Keywords	Principal Investigator 糖鎖工学 / プロテオグリカン / ヒアルロン酸 / コンドロイチン硫酸 / 分化 / 神経 / 性ホルモン / 関節痛 / 月経前症候群 / 細胞外マトリックス … More / 早産 / ウリナスタチン / 糖鎖 / マラリア / オリゴ糖 / 糖転移反応 / ヒアルロニダーゼ / 糖鎖加水分解酵素 / グリコサミノグリカン / 線維化 / 合成阻害 / 4-メチルウンベリフェロン … More Except Principal Investigator プロテオグリカン / グリコサミノグリカン / 軟骨 / デコリン / ヒアルロニダーゼ / エンド-β-キシロシダーゼ / エンド型グリコシダーゼ / 膵癌間質 / ヒアルロン酸 / プロゲステロン / 切迫早産 / 糖鎖工学 / オリゴ糖 / 糖鎖転移反応 / 糖転移反応 / ハイブリッド / 再生医療 / 人工耳介 / 再生 / 生体内再生医療 / 肋軟骨移植 / 小耳症 / 代謝 / 吸収 / 移植 / 膵癌間質制御 / nab-paclitaxel / gemcitabine / 膵星細胞 / 膵臓癌 / 化学療法 / 間質制御 / 膵癌 / O-グリカン / リンパ節転移 / 細胞傷害性Tリンパ球(CTL) / 転移 / 膀胱癌 / 細胞傷害性Tリンパ球 / 腫瘍免疫 / Salmon / Cartilase / Proteoglycan / 老人介護 / プロテオグリカンシート / 癒着防止剤 / 炎症性腸疾患 / 新素材 / プリテオグリカン / サケ / Hyaluronidase / Oligosaccharide / Glycosaminoglycan / デルマタン硫酸 / 糖転移 / 精巣性ヒアルロニダーゼ / コンドロイチン硫酸E / オリゴ糖ライブラリー / sugar chain transfer reaction / hyaluronidase / endo-β -xylosidase / endo-type glycosidase / recombinant protein / glycotechnology / sugar chain reconstruction / proteoglycan / リコンビナントプロテイン / キシロシル-MU-オリゴ糖 / エンド-β-グルクロニダーゼ / エンド-β-グリクロニダーゼ / リコンビナントプロテオグリカン / 糖鎖組み換え / 分子補足 / ソフトスタンプ / ナノドット / ナノテンプレート / 基板表面処理 / 分子捕捉 / 4-methylumbelliferone / 子宮頸管無力症 / 絨毛羊膜炎 / 子宮頸管培養線維芽細胞 / 炎症性サイトカイン / ヒト子宮頸管由来培養線維芽細胞 / オーダーメイド / ペプチド / リコンビナント / 糖鎖転移活性 / リコンビナントタンパク質 / ヒアルロニダーゼSD / 糖鎖のタンパク質への導入 / 糖鎖再構築 Less

ヒアルロン酸の糖鎖工学を活用した脱髄疾患の治療標的分子の探索Principal Investigator
- Principal Investigator
  
  柿崎育子
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  Hirosaki University
Establishment of 4-Methylesculetin-based pancreatic cancer stromal regulation in pancreatic cancer organoids.
- Principal Investigator
  
  石戸圭之輔
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Hirosaki University
生体内再生能を有する微小細切化軟骨をコーティングした人工材料移植技術の開発
- Principal Investigator
  
  四ッ柳高敏
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56070:Plastic and reconstructive surgery-related
- Research Institution
  Sapporo Medical University
糖鎖工学基盤に基づいたコンドロイチン硫酸による神経分化促進機構の解明Principal Investigator
- Principal Investigator
  
  柿崎育子
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  Hirosaki University
Establishment of Pancreatic Stellate Cell Inactivation by Cell Stromal Regulation to Conquer Pancreatic Cancer
- Principal Investigator
  
  Ishido Keinosuke
- Project Period (FY)
  2018 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Hirosaki University
How to be metabolized when the cartilage is transplanted -biochemical research using glycotechnology-
- Principal Investigator
  
  Yotsuyanagi Takatoshi
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56070:Plastic and reconstructive surgery-related
- Research Institution
  Sapporo Medical University
Clarification of the mechanism for arthralgia, one of the premenstrual syndrome symptoms, focusing on the extracellular matrixPrincipal Investigator
- Principal Investigator
  
  Kakizaki Ikuko
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Hirosaki University
A novel mechanism for evasion of CTL immunity by altered O-glycosylation
- Principal Investigator
  
  TSUBOI Shigeru
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Functional biochemistry
- Research Institution
  Hirosaki University
Glycotechnological development of a drug derived from urinastatin for the inhibition of premature deliveryPrincipal Investigator
- Principal Investigator
  
  Kakizaki Ikuko
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Hirosaki University
Development of basic glycotechnology for construction of multifunctional proteoglycan molecules.Principal Investigator
- Principal Investigator
  
  IKUKO Kakizaki
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Functional biochemistry
- Research Institution
  Hirosaki University
A premature delivery forecast and medical treatment new in a keyword are challenged to hyaluronic acid.
- Principal Investigator
  
  ITO Asami
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Hirosaki University
Development of nano-template chip for immobilization and analysis of cartilaginous bio-polymer molecules
- Principal Investigator
  
  MINETA Takashi
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Biomedical engineering/Biological material science
- Research Institution
  Yamagata University
Let's treat preterm labor with Proteoglycan !
- Principal Investigator
  
  TANAKA Kanji
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Hirosaki University
Glycotechnological approaches for prevention of mother-to-child malarial transmissionPrincipal Investigator
- Principal Investigator
  
  KAKIZAKI Ikuko
- Project Period (FY)
  2007 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Functional biochemistry
- Research Institution
  Hirosaki University
ヒアルロン酸合成阻害剤を用いた抗線維化療法の開発Principal Investigator
- Principal Investigator
  
  柿崎育子
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Functional biochemistry
- Research Institution
  Hirosaki University
エンド型グリコシダーゼを用いたプロテオグリカン糖鎖の改変と機能変化
- Principal Investigator
  
  高垣啓一
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Hirosaki University
エンド型グリコシダーゼを用いたリコンビナントプロテオグリカン糖鎖の再生
- Principal Investigator
  
  高垣啓一
- Project Period (FY)
  2003 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Structural biochemistry
- Research Institution
  Hirosaki University
癌補助療法への応用を目指したヒアルロン酸合制抑制剤の作用機構の解明Principal Investigator
- Principal Investigator
  
  柿崎育子
- Project Period (FY)
  2003
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Functional biochemistry
- Research Institution
  Hirosaki University
The application and custom synthesis of glycosaminoglycan oligosaccharides
- Principal Investigator
  
  TAKAGAKI Keiichi
- Project Period (FY)
  2000 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Structural biochemistry
- Research Institution
  Hirosaki University
Development of cartilage proteoglycane as a new medical material
- Principal Investigator
  
  TAKAGAKI Keiichi
- Project Period (FY)
  2000 – 2002
- Research Category
  
  Grant-in-Aid for University and Society Collaboration
- Research Field
  
  Structural biochemistry
- Research Institution
  Hirosaki University
エンド型グリコシダーゼを用いた糖鎖の再構築とその再構築糖鎖のタンパク質の導入
- Principal Investigator
  
  ENDO Masahiko
- Project Period (FY)
  1999
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Hirosaki University
Enzymatic Synthesis of Recombinant-Proteoglycans having Reconstructed Sugar-Chains
- Principal Investigator
  
  ENDO Masahiko
- Project Period (FY)
  1999 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General medical chemistry
- Research Institution
  Hirosaki University

[Book] 『マリンバイオテクノロジーの新潮流』分担執筆2012
- Author(s)
  加藤陽治, 柿崎育子
- Total Pages
  12
- Publisher
  シーエムシー出版
- URL
  http://mineta_lab.yz.yamagata-u.ac.jp/Research-HA-AFM.html
- Data Source
  KAKENHI-PROJECT-23650253
[Book] 『マリンバイオテクノロジーの新潮流』分担執筆,2012
- Author(s)
  加藤陽治, 柿崎育子
- Total Pages
  12
- Publisher
  シーエムシー出版
- Data Source
  KAKENHI-PROJECT-23650253
[Book] マリンバイオテクノロジーの新潮流2011
- Author(s)
  加藤陽治, 柿崎育子
- Publisher
  シーエムシー出版刊
- Data Source
  KAKENHI-PROJECT-23570157
[Book] サケ鼻軟骨由来のプロテオグリカン『マリンバイオテクノロジーの新潮流』2011
- Author(s)
  加藤陽治, 柿崎育子
- Publisher
  シーエムシー出版刊
- Data Source
  KAKENHI-PROJECT-23570157
[Book] Endoglycosidases (Glycosaminoglycans) in Experimental Glycoscience-Glycochemistry (edited by Taniguchi, N., Suzuki, A., Ito, Y., Narimatsu, H., Kawasaki, T., Hase, S)2008
- Author(s)
  Kakizaki, I., Takagaki, K.
- Publisher
  Springer
- Data Source
  KAKENHI-PROJECT-19570119
[Book] Experimental Glycoscience - Glycoscience2008
- Author(s)
  Kakizaki, I., et.al.
- Publisher
  Springer, Berlin, Germany
- Data Source
  KAKENHI-PROJECT-19570119
[Book] Degradation of glycosaminoglycans, in Comprehensive Glycoscience-from Chemistry to Systems Biology (edited by J. P. Kamerling., G. J. Boons., Y. C. Lee., A. Suzuki., N. Taniguchi., A. G. J. Voragen., Elsevier Science B. V.)2007
- Author(s)
  Takagaki, K., Kakizaki, I.
- Publisher
  Elsevier Science B. V.
- Data Source
  KAKENHI-PROJECT-19570119
[Book] New Targets for Cancer Prevention and Therapy2007
- Author(s)
  Kakizaki, I., et al.
- Publisher
  Hirosaki University Press, Hirosaki, Japan(in press)
- Data Source
  KAKENHI-PROJECT-17770106
[Journal Article] A Chondroitin Sulfate Chain of Urinary Trypsin Inhibitor Enhances Protease Inhibitory Activity of the Core Protein2020
- Author(s)
  Teshigahara Yu、Kakizaki Ikuko、Hirao Wataru、Tanaka Kanji、Takahashi Ryoki
- Journal Title
  
  Journal of Applied Glycoscience
  
  Volume: 67 Issue: 2 Pages: 63-66
- DOI
  10.5458/jag.jag.JAG-2019_0021
- NAID
  130007844423
- ISSN
  1344-7882, 1880-7291
- Year and Date
  2020-05-20
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K11262
[Journal Article] Dermatan sulfate oligosaccharides having reducing end 2, 5-anhydro-D-talose inhibit bovine testicular hyaluronidase activity2019
- Author(s)
  Kakizaki I, Koizumi H, Kobayashi T, Nakamura T, Majima M.
- Journal Title
  
  Carbohydrate Research
  
  Volume: 483 Pages: 107754-107754
- DOI
  10.1016/j.carres.2019.107754
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K11068, KAKENHI-PROJECT-17K11262
[Journal Article] Development of new therapeutic agents for preterm birth by glycosaminoglycan chain remodeling of urinary trypsin inhibitor2019
- Author(s)
  Tanaka Seigo、Kakizaki Ikuko、Tanaka Kanji、Kodama Tomoe、Ito-Fukuyama Asami、Suto Shinichiro、Takahashi Ryoki、Yokoyama Yoshihito
- Journal Title
  
  Hypertension Research in Pregnancy
  
  Volume: 7 Issue: 1 Pages: 27-35
- DOI
  10.14390/jsshp.HRP2018-011
- NAID
  130007676864
- ISSN
  2187-5987, 2187-9931
- Year and Date
  2019-03-30
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K11262
[Journal Article] A mechanism for evasion of CTL immunity by altered O-glycosylation of HLA class I.2017
- Author(s)
  Yoneyama MS, Tobisawa Y, Hatakeyama S, Sato M, Tone K, Tatara Y, Kakizaki I, Funyu T, Fukuda M, Hoshi S, Ohyama C, Tsuboi S
- Journal Title
  
  J Biochem.
  
  Volume: 印刷中 Pages: 479-492
- DOI
  10.1093/jb/mvw096
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25220206, KAKENHI-PROJECT-15H02563, KAKENHI-PROJECT-15K06989
[Journal Article] Characterization of Proteoglycan and Hyaluronan in Water-based Delipidated Powder of Salmon Cartilage2015
- Author(s)
  Kakizaki I., Miura, A., Ito, S., Mineta, T., Hong, J.S., and Kato, Y.
- Journal Title
  
  Journal of Applied Glycoscience
  
  Volume: 62 Issue: 3 Pages: 115-120
- DOI
  10.5458/jag.jag.JAG-2015_011
- NAID
  130005094611
- ISSN
  1344-7882, 1880-7291
- Language
  English
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26462470
[Journal Article] Inhibitory effect of chondroitin sulfate oligosaccharides on bovine testicular hyaluronidase.2015
- Author(s)
  Kakizaki, I., Koizumi, H., Chen, F., Endo, M.
- Journal Title
  
  Carbohydr. Polym.
  
  Volume: 121 Pages: 362-371
- DOI
  10.1016/j.carbpol.2014.11.071
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26462470
[Journal Article] Enzymatic synthesis of hyaluronan hybrid urinary trypsin inhibitor.2015
- Author(s)
  Kakizaki, I., Takahashi, R., Yanagisawa, M, Yoshida, F, and Takagaki, K.
- Journal Title
  
  Carbohydr Res.
  
  Volume: 413 Pages: 129-134
- DOI
  10.1016/j.carres.2015.05.009
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26462470
[Journal Article] One set system for the synthesis and purification of glycosaminoglycan oligosaccharides reconstructed using a hyaluronidase-immobilized column.2014
- Author(s)
  Suto, S., Kakizaki, I., Nakamura, T., and Endo, M.
- Journal Title
  
  Biopolymers
  
  Volume: 101(3) Issue: 3 Pages: 189-196
- DOI
  10.1002/bip.22300
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23570157
[Journal Article] Custom synthesis of hyaluronan/chondroitin sulfate hybrid oligosaccharides : for future medical applications, in The 13^<th> Meeting of Hirosaki International Forum of Medical Science"Innovation in Transplant and Regenerative Medicine"2013
- Author(s)
  Kakizaki, I., Suto, S., Tatara, Y., and Endo, M.
- Journal Title
  
  Hirosaki Med. J.
  
  Volume: 64(Suppl) (edited by Oyama, C., et al)
- URL
  http://repository.ul.hirosaki-u.ac.jp/dspace/handle/10129/4866
- Data Source
  KAKENHI-PROJECT-23570157
[Journal Article] Interaction of Listeria monocytogenes autolysin amidase with glycosaminoglycans promotes listerial adhesion to mouse hepatocytes2012
- Author(s)
  Asano, K., Kakizaki, I., and Nakane, A.
- Journal Title
  
  Biochimie
  
  Volume: 94(6) Issue: 6 Pages: 1291-1299
- DOI
  10.1016/j.biochi.2012.02.026
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23570157, KAKENHI-PROJECT-23790467
[Journal Article] Synthesis of neoproteoglycans using the transglycosylation reaction as a reverse reaction of endo-glycosidases2012
- Author(s)
  Endo, M., and Kakizaki, I.
- Journal Title
  
  Proceedings of the Japan Academy, Series B
  
  Volume: 88 Issue: 7 Pages: 327-344
- DOI
  10.2183/pjab.88.327
- NAID
  130001924753
- ISSN
  0386-2208, 1349-2896
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23570157
[Journal Article] Synthesis of neoproteoglycans using the transglycosylation reaction as a reverse reaction of endo-glycosidases2012
- Author(s)
  Endo, M., and Kakizaki, I.
- Journal Title
  
  Proc. Jpn. Acad. Ser. B Phys. Biol. Sci.
  
  Volume: 88(7) Pages: 327-344
- NAID
  130001924753
- URL
  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3422686/.Review
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23570157
[Journal Article] Anti-inflammatory effect of proteo-glycan and progesterone on human uterine cervical fibroblasts2012
- Author(s)
  Fukuyama A, Tanaka K, Kasai K, Nakamura T, Mizunuma H.
- Journal Title
  
  Life Sci
  
  Volume: 90 Issue: 13-14 Pages: 484-488
- DOI
  10.1016/j.lfs.2011.12.024
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591813, KAKENHI-PROJECT-23570157, KAKENHI-PROJECT-23592389
[Journal Article] Hyaluronan-chondroitin hybrid oligosaccharides as new life science research tools.2012
- Author(s)
  Kakizaki, I., Suto, S., Tatara, Y., Nakamura, T., and Endo, M.
- Journal Title
  
  Biochem. Biophys. Res. Commun.
  
  Volume: 423 Issue: 2 Pages: 344-349
- DOI
  10.1016/j.bbrc.2012.05.127
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23570157, KAKENHI-PROJECT-23650253
[Journal Article] Anti-inflammatory effect of proteoglycan and progesterone on human uterine cervical fibroblasts2012
- Author(s)
  Asami Fukuyama, Kanji Tanaka, Ikuko Kakizaki, Kosuke Kasai, Mitsuru Chiba, Toshiya Nakamura, Hideki Mizunuma
- Journal Title
  
  Life Sciences
  
  Volume: 9;90(13-14) Pages: 484-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592389
[Journal Article] Hyaluronan -chondroitin hybrid oligosaccharides as new life science research tools2012
- Author(s)
  I. Kakizaki, S. Suto, Y. Tatara, T. Nakamura, M. Endo
- Journal Title
  
  Biochem. Biophys. Res. Commun
  
  Volume: Vol.423 Pages: 344-349
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23650253
[Journal Article] Identification of proteoglycan from salmon nasal cartilage2011
- Author(s)
  I. Kakizaki, Y. Tatara, M. Majima, Y. Kato, M. Endo
- Journal Title
  
  Arch. Biochem. Biophys
  
  Volume: Vol. 506 (1) Pages: 58-65
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23650253
[Journal Article] Identification of proteoglycan from salmon nasal cartilage2011
- Author(s)
  Kakizaki, I., Tatara, Y., Majima, M., Kato, Y., and Endo, M.
- Journal Title
  
  Arch. Biochem. Biophys
  
  Volume: 506 (1) Pages: 58-65
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23650253
[Journal Article] Effects of divalent cations on bovine testicular hyaluronidase catalyzedtransglycosylation of chondroitin sulfates.2011
- Author(s)
  Kakizaki, L, et. al
- Journal Title
  
  Biochem.Biophys.Res.Commun.
  
  Volume: 406 Pages: 239-244
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591813
[Journal Article] Identification of prteoglycan from salmon nasal cartilage.2011
- Author(s)
  Kakizaki, L, et. al
- Journal Title
  
  Arch.Biochem.Biophys.
  
  Volume: 506 Pages: 58-65
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591813
[Journal Article] Mechanism for the hydrolysis of hyaluronan oligosaccharides by bovine testicular hyaluronidase2010
- Author(s)
  Kakizaki, I., et al
- Journal Title
  
  FEBS J. 277
  
  Pages: 1776-1786
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19570119
[Journal Article] 医学応用を目指したプロテオグリカンの糖鎖工学 (特集/糖質科学の機能探求)2010
- Author(s)
  柿崎育子
- Journal Title
  
  月刊「化学工業」 Vol. 61, No. 3
  
  Pages: 216-220
- Data Source
  KAKENHI-PROJECT-19570119
[Journal Article] 医学応用を目指したプロテオグリカンの糖鎖工学2010
- Author(s)
  柿崎育子
- Journal Title
  
  月刊「化学工業」特集/糖質科学の機能探求 61
  
  Pages: 216-220
- NAID
  130004626746
- Data Source
  KAKENHI-PROJECT-19570119
[Journal Article] Mechanism for the hydrolysis of hyaluronan oligosaccharides by bovine testicular hyaluronidase2010
- Author(s)
  Kakizaki, I., Ibori, N., Kojima, K., Yamaguchi, M., Endo M.
- Journal Title
  
  FEBS J. 277(7)
  
  Pages: 1776-1786
- Data Source
  KAKENHI-PROJECT-19570119
[Journal Article] Novel products in hyaluronan digested by bovine testicular hyaluronidase2009
- Author(s)
  Chen, F., Kakizaki, I., Yamaguchi, M., Kojima, K., Takagaki, K., Endo, M.
- Journal Title
  
  Glycoconj. J. 26(5)
  
  Pages: 559-566
- Data Source
  KAKENHI-PROJECT-19570119
[Journal Article] Up-regulation of hyaluronan synthase genes in cultured human epidermal keratinocytes by UVB irradiation2008
- Author(s)
  Kakizaki, I., Itano, N., Kimata, K., Hanada, K., Kon, A., Yamaguchi, M., Takahashi, T., Takagaki, K.
- Journal Title
  
  Arch. Biochem. Biophys. 471(1)
  
  Pages: 85-93
- Data Source
  KAKENHI-PROJECT-19570119
[Journal Article] Structural Interactions in Chondroitin 4-Sulfate-mediated Adherence of Plasmodium falciparum-infected Erythrocytes in Human Placenta During Pregnancy-Associated Malaria2008
- Author(s)
  Achur, R. N., Kakizaki, I., Goel, S., Kojima, K., Madhunapantula, S. V., Ohta, M., Kumar, S., Takagaki, K., Gowda, D. C.
- Journal Title
  
  Biochemistry 47(47)
  
  Pages: 12635-12643
- Data Source
  KAKENHI-PROJECT-19570119
[Journal Article] Up-regulation of hyaluronan synthase genes in cultured human epidermal keratinocytes by UVB irradiation.2008
- Author(s)
  Kakizaki, I., et al.
- Journal Title
  
  Arch.Biochem.Biophys.
  
  Volume: 471 Pages: 85-93
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19570119
[Journal Article] Diversity in the degree of sulfation and chain length of the glycosaminoglycan moiety of urinary trypsin inhibitor isomers.2007
- Author(s)
  Kakizaki, I., et al.
- Journal Title
  
  Biochim.Biophys.Acta. 1770・2
  
  Pages: 171-177
- Data Source
  KAKENHI-PROJECT-17770106
[Journal Article] Diversity in the degree of sulfation and chain length of the glycosaminoglycan moiety of urinary trypsin inhibitor isomers2007
- Author(s)
  Kakizaki, I., Takahashi, R., Ibori, N., Kojima, K., Takahashi, T., Yamaguchi, M., Kon, A., Takagaki, K.
- Journal Title
  
  Biochim. Biophys. Acta. 1770(2)
  
  Pages: 171-177
- Data Source
  KAKENHI-PROJECT-19570119
[Journal Article] A novel mechanism for the inhibition of hyaluronan Biosynthesis by 4-methylumbelliferone.2004
- Author(s)
  Kakizaki, I., et al.
- Journal Title
  
  J.Biol.Chem. 279
  
  Pages: 33281-33289
- Data Source
  KAKENHI-PROJECT-15370041
[Journal Article] A novel mechanism for the inhibition of hyaluronan Biosynthesis by 4-methylumbelliferone.2004
- Author(s)
  Kakizaki, I., et al.
- Journal Title
  
  J.Biol.Chem. 279
  
  Pages: 33281-33289
- Data Source
  KAKENHI-PROJECT-15040203
[Patent] ヒアルロニダーゼ阻害剤2009
- Inventor(s)
  遠藤正彦, 柿崎育子, 小泉英誉
- Industrial Property Rights Holder
  弘前大学
- Industrial Property Number
  2009-221568
- Filing Date
  2009-09-25
- Data Source
  KAKENHI-PROJECT-19570119
[Patent] ヒアルロニダーゼ阻害剤2009
- Inventor(s)
  遠藤正彦, 柿崎育子
- Industrial Property Rights Holder
  弘前大学
- Industrial Property Number
  2009-221568
- Filing Date
  2009-09-25
- Data Source
  KAKENHI-PROJECT-19570119
[Patent] 特許2008
- Inventor(s)
  柿崎育子遠藤正彦
- Industrial Property Rights Holder
  弘前大学
- Filing Date
  2008-05-22
- Data Source
  KAKENHI-PROJECT-19570119
[Patent] 糖鎖改変方法2008
- Inventor(s)
  柿崎育子, 遠藤正彦
- Industrial Property Rights Holder
  弘前大学
- Industrial Property Number
  2008-133815
- Filing Date
  2008-05-22
- Data Source
  KAKENHI-PROJECT-19570119
[Patent] 糖鎖改変ウリナスタチンの製造方法2007
- Inventor(s)
  柿崎育子, 高垣啓一, 高橋良樹
- Industrial Property Rights Holder
  弘前大学
- Industrial Property Number
  2007-090839
- Filing Date
  2007-03-30
- Data Source
  KAKENHI-PROJECT-19570119
[Presentation] ヒト肋軟骨組織におけるグリコサミノグリカン分布の年齢による違いと皮下埋入後の変化2020
- Author(s)
  北愛里紗　四ッ柳高敏　柿崎育子
- Organizer
  第52回日本結合組織学会学術集会
- Data Source
  KAKENHI-PROJECT-18K09486
[Presentation] Inhibitory effect of oligosaccharides derived from dermatan sulfate on bovine testicular hyaluronidase2017
- Author(s)
  Kakizaki, I., Koizumi, H., Majima, M.
- Organizer
  11th International Conference on Hyaluronan (HA2017)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K11262
[Presentation] ウシ精巣性ヒアルロニダーゼの活性に及ぼすデルマタン硫酸オリゴ糖の阻害効果2017
- Author(s)
  柿崎育子, 小泉英誉, 真嶋光雄
- Organizer
  一般社団法人日本応用糖質科学会平成29年度大会(第66回）
- Data Source
  KAKENHI-PROJECT-17K11262
[Presentation] Measurement of intracellular nucleotide sugar levels in hyaluronan-overproducing breast cancer cells.2015
- Author(s)
  Kakizaki, I., Chanmee, T., Ontong, P., and Itano, N.
- Organizer
  10th International Conference on Hyaluronan (Hyaluronan 2015)
- Place of Presentation
  Florence, Italy
- Year and Date
  2015-06-07
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26462470
[Presentation] Enzymatic synthesis of hyaluronan hybrid urinary trypsin inhibitor.2014
- Author(s)
  Kakizaki, I., Takahashi, R., Yanagisawa, M., Yoshida, T., and Takagaki, K.
- Organizer
  Hirosaki International Symposium on Transplant 2014
- Place of Presentation
  Hirosaki, Japan
- Year and Date
  2014-10-31
- Data Source
  KAKENHI-PROJECT-26462470
[Presentation] Enzymatic synthesis of urinary trypsin inhibitor having an O-linked hyaluronan chain2013
- Author(s)
  Kakizaki, I., Takahashi, R., Yanagisawa, M., Yoshida, T., and Takagaki, K.
- Organizer
  9th International Conference on Hyaluronan (Hyaluronan 2013)
- Place of Presentation
  Oklahoma city, OK, USA
- Data Source
  KAKENHI-PROJECT-23570157
[Presentation] プロテオグリカン分子選択固定化のための基板表面パターン処理の検討2013
- Author(s)
  峯田貴, 洪振瑞, 柿崎育子
- Organizer
  表面技術協会第127回講演大会要旨集
- Place of Presentation
  日本工業大学(埼玉県宮代町)
- Year and Date
  2013-03-18
- Data Source
  KAKENHI-PROJECT-23650253
[Presentation] 酵素を用いたグリコサミノグリカン糖鎖の構造解析2013
- Author(s)
  石岡陽菜,柿崎育子,多田羅洋太,須藤晋一郎,遠藤正彦
- Organizer
  第86回日本生化学会大会
- Place of Presentation
  横浜市
- Year and Date
  2013-09-11
- Data Source
  KAKENHI-PROJECT-23570157
[Presentation] Enzymatic synthesis of urinary trypsin inhibitor having an O-linked hyaluronan chain2013
- Author(s)
  Kakizaki, I., Takahashi, R., Yanagisawa, M., Yoshida, T., and Takagaki, K.
- Organizer
  9^<th>International Conference on Hyaluronan (Hyaluronan 2013)
- Place of Presentation
  Oklahoma city, OK, USA
- Data Source
  KAKENHI-PROJECT-23570157
[Presentation] ヒト子宮頸管線維芽細胞におけるプロテオグリカン及びプロゲステロンの抗炎症効果について2012
- Author(s)
  福山麻美、田中幹二、柿崎育子、中村敏也、水沼英樹
- Organizer
  第7回臨床糖鎖研究会
- Place of Presentation
  青森
- Year and Date
  2012-03-06
- Data Source
  KAKENHI-PROJECT-23592389
[Presentation] ヒアルロニダーゼ固定化酵素を利用した人工オリゴ糖の合成と精製システム2012
- Author(s)
  須藤晋一郎,柿崎育子,多田羅洋太,中村敏也,遠藤正彦
- Organizer
  第85回日本生化学会大会
- Place of Presentation
  福岡市
- Year and Date
  2012-12-15
- Data Source
  KAKENHI-PROJECT-23570157
[Presentation] 日本応用糖質科学会平成23年度大会(第60回)大会特別シンポジウム【応用糖質科学研究の新時代を拓く】2011
- Author(s)
  柿崎育子
- Organizer
  機能解析モデルとしての糖鎖改変プロテオグリカン
- Place of Presentation
  札幌市
- Year and Date
  2011-09-29
- Data Source
  KAKENHI-PROJECT-23570157
[Presentation] サケ鼻軟骨由来プロテオグリカンの糖鎖分析2011
- Author(s)
  柿崎育子、峯田貴、佐々木愛、多田羅洋太、牧野英司、遠藤正彦
- Organizer
  第84回日本生化学会大会
- Place of Presentation
  国立京都国際会館（京都市）
- Data Source
  KAKENHI-PROJECT-23570157
[Presentation] サケ鼻軟骨由来プロテオグリカンの糖鎖分析2011
- Author(s)
  柿崎育子、峯田貴、佐々木愛、多田羅洋太、牧野英司、遠藤正彦
- Organizer
  第84回日本生化学会大会
- Place of Presentation
  国立京都国際会議場（京都市）
- Data Source
  KAKENHI-PROJECT-23650253
[Presentation] プロテオグリカンの糖鎖プロファイリングへのアプローチ2011
- Author(s)
  柿崎育子
- Organizer
  第5回 GFRG研究会公開シンポジウム
- Place of Presentation
  弘前大学医学部コミュケーションセンター（弘前市）
- Data Source
  KAKENHI-PROJECT-23650253
[Presentation] プロテオグリカン、プロゲステロンの抗炎症作用を利用した切迫早産治療に関する基礎的研究2011
- Author(s)
  福山麻美、田中幹二、柿崎育子、中村敏也、水沼英樹
- Organizer
  第5回日本早産予防研究会
- Place of Presentation
  東京
- Year and Date
  2011-12-03
- Data Source
  KAKENHI-PROJECT-23592389
[Presentation] サケ鼻軟骨由来プロテオグリカンの糖鎖分析2011
- Author(s)
  柿崎育子,峯田貴,佐々木愛,多田羅洋太,牧野英司,遠藤正彦
- Organizer
  第84回日本生化学会大会
- Place of Presentation
  京都市
- Year and Date
  2011-09-23
- Data Source
  KAKENHI-PROJECT-23570157
[Presentation] プロテオグリカンの糖鎖プロファイリングへのアプローチ2011
- Author(s)
  柿崎育子
- Organizer
  第5回GFRG 研究会公開シンポジウム
- Place of Presentation
  弘前大学医学部コミュケーションセンター( 弘前市)
- Year and Date
  2011-10-05
- Data Source
  KAKENHI-PROJECT-23650253
[Presentation] 機能解析モデルとしての糖鎖改変プロテオグリカン2011
- Author(s)
  柿崎育子
- Organizer
  日本応用糖質科学会平成23年度大会（第60回）
- Place of Presentation
  北海道大学学術交流会館（札幌市）
- Data Source
  KAKENHI-PROJECT-23570157
[Presentation] 人工ハイブリッドヒアルロナンとヒアルロナン結合タンパク質の結合2011
- Author(s)
  須藤晋一郎,柿崎育子,多田羅洋太,中村敏也,遠藤正彦
- Organizer
  第84回日本生化学会大会
- Place of Presentation
  京都市
- Year and Date
  2011-09-23
- Data Source
  KAKENHI-PROJECT-23570157
[Presentation] サケ鼻軟骨由来プロテオグリカンの糖鎖分析2011
- Author(s)
  柿崎育子, 峯田貴, 佐々木愛, 多田羅洋太, 牧野英司, 遠藤正彦
- Organizer
  第84回日本生化学会大会
- Place of Presentation
  国立京都国際会議場( 京都市)
- Year and Date
  2011-09-23
- Data Source
  KAKENHI-PROJECT-23650253
[Presentation] Mechanism bywhich bovine testicular hyaluronidase hydrolyses hvaluronan2010
- Author(s)
  Kakizaki, L, et.al
- Organizer
  International Conference on Hyaluronan
- Place of Presentation
  京都ブライトンホテル(京都市)
- Data Source
  KAKENHI-PROJECT-22591813
[Presentation] サケ軟骨プロテオグリカンのコアタンパク質の構造解析2010
- Author(s)
  柿崎育子
- Organizer
  日本生化学会大会
- Place of Presentation
  神戸ポートアイランド(神戸市)
- Year and Date
  2010-12-09
- Data Source
  KAKENHI-PROJECT-22591813
[Presentation] 大会特別シンポジウム【東北から発信する糖質関連新技術】,「医学応用を目指したプロテオグリカンの糖鎖工学」2009
- Author(s)
  柿崎育子
- Organizer
  日本応用糖質科学会平成21年度大会 (第58回)
- Place of Presentation
  弘前市
- Year and Date
  2009-09-17
- Data Source
  KAKENHI-PROJECT-19570119
[Presentation] 医学応用を目指したプロテオグリカンの糖鎖工学2009
- Author(s)
  柿崎育子
- Organizer
  日本応用糖質科学会平成21年度大会(第58回)
- Place of Presentation
  弘前市
- Year and Date
  2009-09-17
- Data Source
  KAKENHI-PROJECT-19570119
[Presentation] ビアルロニダーゼ固定化カラムを用いた糖転移反応の再検討2007
- Author(s)
  柿崎育子, 他
- Organizer
  第30回日本分子生物学会年会第80回日本生化学会大会合同年会
- Place of Presentation
  横浜市
- Year and Date
  2007-12-14
- Data Source
  KAKENHI-PROJECT-19570119
[Presentation] ヒアルロニダーゼ固定化カラムを用いた糖転移反応の再検討2007
- Author(s)
  柿崎育子, 須藤晋一郎, 今淳, 山口真範, 遠藤正彦
- Organizer
  第30回日本分子生物学会年会第80回日本生化学会大会合同年会
- Place of Presentation
  横浜
- Year and Date
  2007-12-14
- Data Source
  KAKENHI-PROJECT-19570119
[Presentation] 尿中トリプシンインヒビターのグリコサミノグリカン糖鎖の酵素的組み換え2007
- Author(s)
  柿崎育子, 他
- Organizer
  第27回日本糖質学会年会
- Place of Presentation
  福岡市
- Year and Date
  2007-08-01
- Data Source
  KAKENHI-PROJECT-19570119
[Presentation] プロテオグリカン分子選択固定化のための基板表面パターン処理の検討
- Author(s)
  峯田貴，洪振瑞，柿崎育子
- Organizer
  表面技術協会第127回講演大会要旨集
- Place of Presentation
  日本工業大学(埼玉県宮代町)
- Data Source
  KAKENHI-PROJECT-23650253

1. TAKAGAKI Keiichi (70163160)

# of Collaborated Projects: 6 results

# of Collaborated Products: 0 results
2. TANAKA Kanji (20311540)

# of Collaborated Projects: 4 results

# of Collaborated Products: 4 results
3. IWAFUNE Mito (80312487)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
4. FUKUYAMA Asami (30536511)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
5. ENDO Masahiko (20004616)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. Ishido Keinosuke (00436023)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. Yotsuyanagi Takatoshi (70250595)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. 袴田健一 (30271802)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
9. 木村憲央 (60436029)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
10. 山下建 (30312507)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
11. MINETA Takashi (50374814)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
12. YOSHIHARA Syuichi (00261454)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. KATO Yoji (20194863)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. TSUBOI Shigeru (20526727)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 今淳 (60271798)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 大山力 (80282135)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
17. 工藤大輔 (00587024)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 脇屋太一 (50571246)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 浜本有祐 (10380180)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 北愛里紗 (20642185)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. 長瀬勇人 (10750862)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. 若狭悠介 (70770783)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. 小林孝安 (10221970)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. 山口真範 (20400129)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. 四ツ柳高敏

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
26. 中村敏也

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Kakizaki Ikuko 柿崎 育子

KAKIZAKI Ikuko 柿崎 育子

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ヒアルロン酸の糖鎖工学を活用した脱髄疾患の治療標的分子の探索Principal Investigator

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糖鎖工学基盤に基づいたコンドロイチン硫酸による神経分化促進機構の解明Principal Investigator

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Clarification of the mechanism for arthralgia, one of the premenstrual syndrome symptoms, focusing on the extracellular matrixPrincipal Investigator

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Glycotechnological development of a drug derived from urinastatin for the inhibition of premature deliveryPrincipal Investigator

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Development of basic glycotechnology for construction of multifunctional proteoglycan molecules.Principal Investigator

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Glycotechnological approaches for prevention of mother-to-child malarial transmissionPrincipal Investigator

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Kakizaki Ikuko 柿崎育子

KAKIZAKI Ikuko 柿崎育子