TAKAGI Keiichi 高垣啓一

… Alternative Names

高垣啓一

Less

Researcher Number	70163160
External Links
Affiliation (based on the past Project Information) *help	2002 – 2006: Hirosaki University, School of Medicine, Biochemistry, Professor, 医学部, 教授 1992 – 2002: 弘前大学, 医学部, 助教授 1999: 引前大学, 医学部, 助教授 1986: 弘前大学, 医学部, 助手
Review Section/Research Field	Principal Investigator Structural biochemistry / Biological Sciences / Structural biochemistry Except Principal Investigator General medical chemistry / Dermatology / Dermatology / Functional biochemistry / Structural biochemistry
Keywords	Principal Investigator プロテオグリカン / グリコサミノグリカン / デコリン / エンド-β-キシロシダーゼ / オリゴ糖 / 糖鎖工学 / エンド型グリコシダーゼ / 糖鎖転移活性 / 糖鎖転移反応 / リコンビナント … More / ペプチド / オーダーメイド / クレコサミノグリカン / 糖転移反応 / イオンスプレー質量分析計 / glycotechnology / glycosaminoglycan / endoglycosidase / transglycosylation / ion-spray mass spectrometry / ヒアルロニダーゼ / オリゴ糖ライブラリー / コンドロイチン硫酸E / 精巣性ヒアルロニダーゼ / 糖転移 / デルマタン硫酸 / Glycosaminoglycan / Oligosaccharide / Hyaluronidase / 軟骨 / サケ / プリテオグリカン / 新素材 / 炎症性腸疾患 / 癒着防止剤 / プロテオグリカンシート / 老人介護 / Proteoglycan / Cartilase / Salmon … More Except Principal Investigator エンド型グリコシダーゼ / ヒアルロン酸 / 糖鎖再構築 / ヒアルロニダーゼ / 糖鎖組み換え / 糖転移反応 / 細胞外マトリックス / 糖鎖のタンパク質への導入 / 生理活性ドメイン / 胎児創傷治癒 / 再生 / 糖鎖工学 / 糖鎖導入のキャリヤ- / 4-メチルウンベリフェロン誘導糖鎖 / エンド-β-キシロシダーゼ / 瘢痕 / 組織工学 / SAGE法 / プロテオグリカン / グリコサミノグリカン / glycotechnology / endo-type glycosidase / 合成阻害剤 / ヒト皮膚線維芽細胞 / 4-メチルウンベリフェロン / Inhibitor / Extracellular matrix / 4-Methylumbelliferone / hyaluronidase / sugar chain reconstruction / scarless wound healing / VII型コラーゲン / 糖鎖導入のキャリヤー / ヒアルロニダーゼSD / リコンビナントタンパク質 / ヒアルロン酸合成酵素 / ヒアルロン酸の分解 / グリコサミノグリカリンの分解 / ヒアルロン酸尿症 / エンド-ベータ-グルクロニダーゼ / ベータ--グルクロニダーゼ / ウェルナー症侯群 / ヒアルロン酸分解酵素 / 糖鎖の切り出し / 生理活性ドメイン糖鎖 / 糖鎖の再構築 / Proteoglycan / carbohydrate chain reconstruction / glycosaminoglycan / physiological domain / extracellular matrix / デコリン / Hyaluronic acid / Human skin fibroblasts / Decorin / 人工プロテオグリカン / 糖鎖の組み換え / コンドロイチン硫酸 / 酵素的糖鎖合成 / 酵素的合成 / 4メチルウンベリフェロン誘導オリゴ糖 / artificial proteoglycan / transglycosylation / endo-beta-xylosidase / ヒアルロン酸低分子化酵素 / ストロムライシン-1 / ヘパラン硫酸 / ヘパリチナーゼ / マトリックスメタロプロテアーゼ / 線維芽細胞 / Hyaluronan / Hyaluronan-degrading enzyme / Human skin fibroblast / Matrix metalloproteninase / Stromelysin-1 / リコンビナントプロテオグリカン / エンド-β-グリクロニダーゼ / 糖鎖転移反応 / エンド-β-グルクロニダーゼ / キシロシル-MU-オリゴ糖 / リコンビナントプロテイン / proteoglycan / recombinant protein / endo-β -xylosidase / sugar chain transfer reaction / scar / hyaluronic acid / regeneration / tissue engineering / SAGE / 表皮水疱症 / 栄養障害型 / 重症 / ラミニン5 / 蛋白補充 / 遺伝子導入 / 真皮 / epidermolysis bullosa / dystrophic / severe / type VII collagen / laminin 5 / protein therapy / gene transfer / dermis / 遺伝子 / 糖鎖 / 創傷治癒 / 皮膚 / tvoe VII collagen / hvaluronan Less

Elucidation of the mechanism of scarless wound healing and identification of its master gene
- Principal Investigator
  
  KON Atsushi
- Project Period (FY)
  2005 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Dermatology
- Research Institution
  Aomori University of Health and Welfare
  Hirosaki University
エンド型グリコシダーゼを用いたプロテオグリカン糖鎖の改変と機能変化Principal Investigator
- Principal Investigator
  
  高垣啓一
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Hirosaki University
エンド型グリコシダーゼを用いたリコンビナントプロテオグリカン糖鎖の再生Principal Investigator
- Principal Investigator
  
  高垣啓一
- Project Period (FY)
  2003 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Structural biochemistry
- Research Institution
  Hirosaki University
Establishment of a system in which type VII collagen and laminin 5 or their genes are continuously delivered from the dermal side to the basement membrane zone
- Principal Investigator
  
  SAWAMURA Daisuke
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Dermatology
- Research Institution
  HOKKAIDO UNIVERSITY
皮膚の再生機構の解明:ヒアルロン酸合成酵素遺伝子導入による胎児創傷治癒機構モデルの開発
- Principal Investigator
  
  水木大介
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Dermatology
- Research Institution
  Hirosaki University
Molecular mechanism of scarless wound healing its application for therapy of epidermolysis bullosa
- Principal Investigator
  
  KON Atsushi
- Project Period (FY)
  2001 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Dermatology
- Research Institution
  Hirosaki University
The application and custom synthesis of glycosaminoglycan oligosaccharidesPrincipal Investigator
- Principal Investigator
  
  TAKAGAKI Keiichi
- Project Period (FY)
  2000 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Structural biochemistry
- Research Institution
  Hirosaki University
Development of cartilage proteoglycane as a new medical materialPrincipal Investigator
- Principal Investigator
  
  TAKAGAKI Keiichi
- Project Period (FY)
  2000 – 2002
- Research Category
  
  Grant-in-Aid for University and Society Collaboration
- Research Field
  
  Structural biochemistry
- Research Institution
  Hirosaki University
エンド型グリコシダーゼを用いた糖鎖の再構築とその再構築糖鎖のタンパク質の導入
- Principal Investigator
  
  遠藤正彦
- Project Period (FY)
  1999
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Hirosaki University
Enzymatic Synthesis of Recombinant-Proteoglycans having Reconstructed Sugar-Chains
- Principal Investigator
  
  ENDO Masahiko
- Project Period (FY)
  1999 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General medical chemistry
- Research Institution
  Hirosaki University
エンド型グリコシダーゼを用いた糖鎖の再構築とその再構築糖鎖のタンパク質への導入
- Principal Investigator
  
  遠藤正彦
- Project Period (FY)
  1998
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Hirosaki University
Quantitative and qualitative control of hyaluronan which plays a role in the assembly of extracellular matrix as a backbone of proteoglycan aggregate
- Principal Investigator
  
  NAKAMURA Toshiya
- Project Period (FY)
  1998 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Structural biochemistry
- Research Institution
  Hirosaki University
エンド型グリコシダーゼを用いた糖鎖の再構築とその再構築糖鎖のタンパク質への導入
- Principal Investigator
  
  ENDO Masahiko
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Hirosaki University
Enzymatic Synthesis of Artificial Proteoglycans Having Reconstructed Sugar Chains
- Principal Investigator
  
  ENDO Masahiko
- Project Period (FY)
  1996 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General medical chemistry
- Research Institution
  HIROSAKI UNIVERSITY
Formation of hyaluronic-acid-deficient extracellular matrix induced by an inhibitor for hyaluronic acid synthesis
- Principal Investigator
  
  NAKAMURA Toshiya
- Project Period (FY)
  1995 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Functional biochemistry
- Research Institution
  Hirosaki University
Studies to develop new methods of glycotechnology with glycosaminoglycan.Principal Investigator
- Principal Investigator
  
  TAKAGAKI Keiichi
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Structural biochemistry
- Research Institution
  HIROSAKI UNIVERSITY
The studies of glycotechnology on the restriction of carbohydrate chain bearing physiological functions of proteoglycans
- Principal Investigator
  
  ENDO Masahiko
- Project Period (FY)
  1992 – 1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  General medical chemistry
- Research Institution
  HIROSAKI UNIVERSITY
結合組織を形成しているヒアルロン酸の代謝とヒアルロン酸尿症に関する研究
- Principal Investigator
  
  遠藤正彦
- Project Period (FY)
  1986
- Research Category
  
  Grant-in-Aid for Special Project Research
- Research Institution
  Hirosaki University

All 2007 2006 2005

All Journal Article

[Journal Article] Diversity in the degree of sulfation and chain length of the glycosaminoglycan moiety of urinary trypsin inhibitor isomers.2007
- Author(s)
  Kakizaki I, Takahashi R, Ibori N, Kojima K, Takahashi T, Yamaguchi M, Kon A, Takagaki K
- Journal Title
  
  Biochim Biophys Acta 1770(2)
  
  Pages: 171-177
- Data Source
  KAKENHI-PROJECT-17591153
[Journal Article] 4-methylumbelliferone, a hyaluronan synthase suppressor, enhances the anticancer activity of gemcitabine in human pancreatic cancer cells.2006
- Author(s)
  Nakazawa H, Yoshihara S, Kudo D, Morohashi H, Kakizaki I, Kon A, Takagaki K, Sasaki M
- Journal Title
  
  Cancer Chemother Pharmacol 57(2)
  
  Pages: 165-170
- Data Source
  KAKENHI-PROJECT-17591153
[Journal Article] プロテオグリカンの糖鎖工学的・医学的応用2006
- Author(s)
  高垣啓一, 山口真範
- Journal Title
  
  月刊「化学工業」 57・5
  
  Pages: 60-67
- NAID
  40007270979
- Data Source
  KAKENHI-PROJECT-15370041
[Journal Article] L457F missense mutation within the 2B rod domain of keratin 9 in a Japanese family with epidermolytic palmoplantar keratoderma.2006
- Author(s)
  Kon A, Ito N, Kudo Y, Nomura K, Yoneda K, Hanada K, Hashimoto I, Takagaki K
- Journal Title
  
  Br J Dermatol. 155(3)
  
  Pages: 624-626
- Data Source
  KAKENHI-PROJECT-17591153
[Journal Article] Study of hyaluronan synthase inhibitor, 4-methylumbelliferone derivatives on human pancreatic cancer cell (KP1-NL).2006
- Author(s)
  Morohashi H, Kon A, Nakai M, Yamaguchi M, Kakizaki I, Yoshihara S, Sasaki M, Takagaki K
- Journal Title
  
  Biochem Biophys Res Commun. 345(4)
  
  Pages: 1454-1459
- Data Source
  KAKENHI-PROJECT-17591153
[Journal Article] 4-methylumbelliferone, a hyaluronan synthase suppressor, enhances the anticancer activity of gemcitabine in human pancreatic cancer cells.2005
- Author(s)
  Nakazawa H, Yoshihara S, Kudo D, Morohashi H, Kakizaki I, Kon A, Takagaki K, Sasaki M
- Journal Title
  
  Cancer Chemoth Pharm 57
  
  Pages: 165-170
- Data Source
  KAKENHI-PROJECT-17591153
[Journal Article] Tissue-specific downregulation of type VII collagen gene (COL7A1) transcription in cultured epidermal keratinocytes by ultraviolet A radiation (UVA) and UVA-related cytokines, with special reference to cutaneous photoaging.2005
- Author(s)
  Kon A, Takeda H, Ito N, Hanada K, Takagaki K
- Journal Title
  
  J Dermatol Sci 1(suppl)
  
  Pages: 29-35
- Data Source
  KAKENHI-PROJECT-17591153
[Journal Article] Keratinocyte-specific modulation of type VII collagen gene expression by pro-inflammatory cytokines (tumor necrosis factor-α and interleukin-1β).2005
- Author(s)
  Takeda H, Kon A, Ito N, Sawamura D, Takagaki K, Hashimoto I, Hanada K
- Journal Title
  
  Exp Dermatol 14
  
  Pages: 289-295
- Data Source
  KAKENHI-PROJECT-17591153
[Journal Article] A Hyaluronan synthase suppressor, 4-methylumbelliferone, inhibits liver metastasis of melanoma cells.2005
- Author(s)
  Yoshihara S, Kon A, Kudo D, Nakazawa H, Kakizaki I, Sasaki M, Endo M, Takagaki K
- Journal Title
  
  FEBS Lett 579
  
  Pages: 2722-2726
- Data Source
  KAKENHI-PROJECT-17591153

1. ENDO Masahiko (20004616)

# of Collaborated Projects: 7 results

# of Collaborated Products: 0 results
2. KAKIZAKI Ikuo (80302024)

# of Collaborated Projects: 6 results

# of Collaborated Products: 0 results
3. MUNAKATA Hidekazu (80271807)

# of Collaborated Projects: 5 results

# of Collaborated Products: 0 results
4. NAKAMURA Toshiya (00155847)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
5. KON Atsushi (60271798)

# of Collaborated Projects: 4 results

# of Collaborated Products: 8 results
6. IWAFUNE Mito (80312487)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
7. SAWAMURA Daisuke (60196334)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
8. IZUMI Jun (20241458)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
9. YOSHIHARA Syuichi (00261454)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. KATO Yoji (20194863)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. MATSUZAKI Yasushi (50322946)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. TABATA Yasuhiko (50211371)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. SHIMIZU Hiroshi (00146672)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. AKIYAMA Masashi (60222551)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. YAMAGUCHI Masanori (20400129)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
16. 水木大介 (60322947)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 花田勝美 (80091627)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 松江一 (30106843)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 工藤一 (40003397)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 玉井克人 (20236730)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. 佐藤宏 (90211945)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. 沢村大輔

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

TAKAGI Keiichi 高垣 啓一

高垣 啓一

Research Projects

Research Products

Co-Researchers

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

エンド型グリコシダーゼを用いたプロテオグリカン糖鎖の改変と機能変化Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

エンド型グリコシダーゼを用いたリコンビナントプロテオグリカン糖鎖の再生Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The application and custom synthesis of glycosaminoglycan oligosaccharidesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of cartilage proteoglycane as a new medical materialPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

TAKAGI Keiichi 高垣啓一

高垣啓一