Nakamura Toshiya 中村敏也

… Alternative Names

Researcher Number	00155847
Other IDs
Affiliation (based on the past Project Information) *help	2018 – 2020: 弘前大学, 保健学研究科, 教授 2014: 弘前大学, 大学院保健学研究科, 教授 2008 – 2010: 弘前大学, 大学院・保健学研究科, 教授 2000: Hirosaki University, School of Medicine, Associate Professor, 医学部, 助教授 1997 – 1999: 弘前大学, 医療技術短期大学部, 助教授 … More
Review Section/Research Field	Principal Investigator Functional biochemistry / Structural biochemistry / Basic Section 59040:Nutrition science and health science-related Except Principal Investigator Food science / Laboratory medicine / General medical chemistry
Keywords	Principal Investigator ヒアルロン酸 / 合成阻害剤 / 細胞外マトリックス / ヒト皮膚線維芽細胞 / 4-メチルウンベリフェロン / Inhibitor / Extracellular matrix / 4-Methylumbelliferone / デコリン / Hyaluronic acid … More Except Principal Investigator 蛋白質ホスファタ-ゼ / 細胞分化 / メッセンジャ-RNA / 分子生物学 / リンゴプロシアニジン / 肥満 / 抗腫瘍効果 / アディポネクチン / ポリフェノール / プロシアニジン / アディポカイン / 抗腫瘍 / アデイポカイン / 放射線被ばく / 血清中microRNA / バイオマーカー / microRNA / 血清 / 被ばくバイオマーカー / エキソソーム / RNA / ヒアルロン酸の分解 / グリコサミノグリカリンの分解 / ヒアルロン酸尿症 / エンド-ベータ-グルクロニダーゼ / ベータ--グルクロニダーゼ / ウェルナー症侯群 / ヒアルロン酸分解酵素 / 人工プロテオグリカン / ヒアルロニダーゼ / 糖転移反応 / 糖鎖組み換え / エンド-β-キシロシダーゼ / 糖鎖の組み換え / コンドロイチン硫酸 / ヒアルロン酸 / 酵素的糖鎖合成 / 細胞外マトリックス / 糖鎖工学 / エンド型グリコシダーゼ / 酵素的合成 / 糖鎖再構築 / 糖鎖導入のキャリヤ- / 4メチルウンベリフェロン誘導オリゴ糖 / artificial proteoglycan / hyaluronidase / transglycosylation / sugar chain reconstruction / endo-beta-xylosidase Less

Elucidation of the biological defense mechanism of chondroitin sulfate on the intestinal tractPrincipal Investigator
- Principal Investigator
  
  Nakamura Toshiya
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  Hirosaki University
The development of novel internal radiation dosimetry using circulating exosomal RNAs into body fluids
- Principal Investigator
  
  CHIBA Mitsuru
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Laboratory medicine
- Research Institution
  Hirosaki University
Adipokine regulation and antitumor effect by apple procyanidins
- Principal Investigator
  
  KASAI Kosuke, MIURA Tomisato
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Food science
- Research Institution
  Hirosaki University
Quantitative and qualitative control of hyaluronan which plays a role in the assembly of extracellular matrix as a backbone of proteoglycan aggregatePrincipal Investigator
- Principal Investigator
  
  NAKAMURA Toshiya
- Project Period (FY)
  1998 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Structural biochemistry
- Research Institution
  Hirosaki University
Enzymatic Synthesis of Artificial Proteoglycans Having Reconstructed Sugar Chains
- Principal Investigator
  
  ENDO Masahiko
- Project Period (FY)
  1996 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General medical chemistry
- Research Institution
  HIROSAKI UNIVERSITY
Formation of hyaluronic-acid-deficient extracellular matrix induced by an inhibitor for hyaluronic acid synthesisPrincipal Investigator
- Principal Investigator
  
  NAKAMURA Toshiya
- Project Period (FY)
  1995 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Functional biochemistry
- Research Institution
  Hirosaki University
細胞増殖の調節、癌細胞の形質保持における蛋白質ホスファタ-ゼの機能に関する研究
- Principal Investigator
  
  田村真理
- Project Period (FY)
  1990
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Hirosaki University
結合組織を形成しているヒアルロン酸の代謝とヒアルロン酸尿症に関する研究
- Principal Investigator
  
  ENDO Masahiko
- Project Period (FY)
  1986
- Research Category
  
  Grant-in-Aid for Special Project Research
- Research Institution
  Hirosaki University

All 2021 2020 2019 2018 2015 2010 Other

All Journal Article Presentation Patent

[Journal Article] Radiation Safety and Public Health for Radiological Professionals: Meeting Report on The 5th Educational Symposium on Radiation and Health (ESRAH) by Young Scientists in 2018.2021
- Author(s)
  Yamashina Hiroko, Terashima Marin, Oikawa Joma, Naijo Shingo, Miyao Tamao, Yachi Yoshie, Matsuya Yusuke, Yamaguchi Masaru, Tsujiguchi Takakiyo, Saga Ryo, Jun Hu, Goh Valerie Swee Ting, Nakamura Toshiya, Hosokawa Yoichiro, Date Hiroyuki.
- Journal Title
  
  Radiation Environment and Medicine
  
  Volume: 10 Pages: 48-54
- NAID
  40022494206
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K11068
[Journal Article] Metal coordination by L-amino acid oxidase derived from flounder Platichthys stellatus is structurally essential and regulates antibacterial activity2020
- Author(s)
  Kasai Kosuke、Ito Yudai、Nitta Akihide、Ariyoshi Kentaro、Nakamura Toshiya、Miura Tomisato
- Journal Title
  
  Applied Microbiology and Biotechnology
  
  Volume: 104 Pages: 9645-9654
- DOI
  10.1007/s00253-020-10914-3
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K12354, KAKENHI-PROJECT-18K11068
[Journal Article] Phosphorylation of Thr328 in hyaluronan synthase 2 is essential for hyaluronan synthesis2020
- Author(s)
  Kasai Kosuke、Kuroda Yoshiyuki、Takabuchi Yutaro、Nitta Akihide、Kobayashi Takashi、Nozaka Hiroyuki、Miura Tomisato、Nakamura Toshiya
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 533 Pages: 732-738
- DOI
  10.1016/j.bbrc.2020.08.093
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K11068
[Journal Article] Dermatan sulfate oligosaccharides having reducing end 2, 5-anhydro-D-talose inhibit bovine testicular hyaluronidase activity2019
- Author(s)
  Kakizaki I, Koizumi H, Kobayashi T, Nakamura T, Majima M.
- Journal Title
  
  Carbohydrate Research
  
  Volume: 483 Pages: 107754-107754
- DOI
  10.1016/j.carres.2019.107754
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K11068, KAKENHI-PROJECT-17K11262
[Journal Article] Regulation of radiosensitivity by 4-methylumbelliferone via the suppression of interleukin‐1 in fibrosarcoma cells.2019
- Author(s)
  Saga R, Hasegawa K, Murata K, Chiba M, Nakamura T, Okumura K, Tsuruga E, Hosokawa Y.
- Journal Title
  
  Oncology Letters
  
  Volume: 17 Pages: 3555-3561
- DOI
  10.3892/ol.2019.9990
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K11068, KAKENHI-PROJECT-17K16413, KAKENHI-PROJECT-15K11265
[Journal Article] Lessons From a Japan-Korea Collaboration on Medical Response Training for a Nuclear or Radiological Emergency, Assuming Mass Casualty2019
- Author(s)
  Tsujiguchi T, Kitajima M, Tomisawa T, Shiroto Y, Yamada R, Saito K, Hanada H, Jin Y-W, Cho M, Jang S, Kim H, Pak M, Nakamura T.
- Journal Title
  
  Disaster Medicine and Public Health Preparedness
  
  Volume: Sep 30 Pages: 1-2
- DOI
  10.1017/dmp.2019.88
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K11068
[Journal Article] Meeting report on "The 4th Educational Symposium on Radiation and Health (ESRAH) by Young Scientists in 2017"2018
- Author(s)
  Saga R, Tsujiguchi T, Yamaguchi M, Fukushi Y, Fujishima Y, Matsuya Y, Oikawa J, Terashima M, Date H, Nakamura T, Hosokawa Y.
- Journal Title
  
  Radiation Environment and Medicine
  
  Volume: 7 Pages: 121-124
- NAID
  40021646787
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K11068
[Journal Article] Proteoglycan-substrate gel zymography for the detection of chondroitin sulfate-degrading enzymes2018
- Author(s)
  Kobayashi T, Kakizaki I, Nakamura T
- Journal Title
  
  Analytical Biochemistry
  
  Volume: 568 Pages: 51-52
- DOI
  10.1016/j.ab.2018.12.010
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K11068
[Journal Article] Blackcurrant anthocyanins increase the levels of collagen, elastin, and hyaluronic acid in human skin fibroblasts and ovariectomized rats2018
- Author(s)
  Nanashima Naoki、Horie Kayo、Maeda Hayato、Tomisawa Toshiko、Kitajima Maiko、Nakamura Toshiya
- Journal Title
  
  Nutrients
  
  Volume: 10 Pages: 495-495
- DOI
  10.3390/nu10040495
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K00844, KAKENHI-PROJECT-18K11068
[Journal Article] The report of the 1st Educational Symposium on Radiation and Health by Young Scientists (ESRAH2014).2015
- Author(s)
  Masahiro Hosoda, Hironori Yoshino, Masaru Yamaguchi, Takakiyo Tsujiguchi, Mitsuru Chiba, Toshiya Nakamura.
- Journal Title
  
  Japanese Journal of Health Physics
  
  Volume: 50
- NAID
  130005113883
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25670264
[Journal Article] A hyaluronan synthase suppressor, 4-methylumbelliferone, inhibits the tumor invasion associated with N-cadherin decreasement.2010
- Author(s)
  Kuwabara H, Yoneda M, Hayasaki H, Nakamura T, Shibayama Y.
- Journal Title
  
  Pathol Int.
  
  Volume: 61 Pages: 262-263
- NAID
  10031185082
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20580121
[Journal Article] A hyaluronan synthase suppressor, 4-methylumbelliferone, inhibits the tumor invasion associated with N-cadherin decreasement.2010
- Author(s)
  Kuwabara H, Nakamura T, et al
- Journal Title
  
  Pathol Int. 61
  
  Pages: 262-263
- NAID
  10031185082
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20580121
[Journal Article] Novel L-amino acid oxidase with antibacterial activity against methicillin-resistant Staphylococcus aureus isolated from epidermal mucus of the flounder Platichthys stellatus.2010
- Author(s)
  Kasai K, Ishikawa T, Komata T, Fukuchi K, Chiba M, Nozaka H, Nakamura T, Sato T, Miura T.
- Journal Title
  
  FEBS J
  
  Volume: 277 Pages: 453-465
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20580121
[Patent] グリコサミノグリカン分解酵素又はその阻害物質の検出方法2018
- Inventor(s)
  中村敏也，柿崎育子，小林　孝
- Industrial Property Rights Holder
  弘前大学
- Industrial Property Rights Type
  特許
- Filing Date
  2018
- Data Source
  KAKENHI-PROJECT-18K11068
[Presentation] マウスに経口投与されたプロテオグリカンの小腸における消化産物2020
- Author(s)
  工藤　海，小林　孝，葛西宏介，横山洸大，作田泰宏，中村敏也
- Organizer
  第93回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-18K11068
[Presentation] サケ鼻軟骨プロテオグリカンを使ったコンドロイチン硫酸分解酵素の検出2018
- Author(s)
  小林　孝、柿崎育子、中村敏也
- Organizer
  第9１回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-18K11068
[Presentation] Serum microRNAs as potential biomarkers in mice exposed to ionizing radiation.
- Author(s)
  Mitsuru Chiba, Satoru Monzen, Ikuo Kashiwakura, Toshiya Nakamura
- Organizer
  The 2nd Educational Synposium on Radiation and Health for Young Scientists (ESRAH2015)
- Place of Presentation
  Hirosaki University (Aomori)
- Year and Date
  2015-05-23 – 2015-05-24
- Data Source
  KAKENHI-PROJECT-25670264
[Presentation] Serum microRNAs as potential biomarkers in mice exposed to ionizing radiation.
- Author(s)
  Mitsuru Chiba, Satoru Monzen, Ikuo Kashiwakura, Toshiya Nakamura
- Organizer
  15th International Congress of Radiation Research (ICRR2015)
- Place of Presentation
  Kyoto International Conference Center (Kyoto)
- Year and Date
  2015-05-25 – 2015-05-29
- Data Source
  KAKENHI-PROJECT-25670264

1. TAKAGAKI Keiichi (70163160)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
2. MUNAKATA Hidekazu (80271807)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
3. KASAI Kosuke (50400148)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
4. MIURA Tomisato (20261456)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
5. ENDO Masahiko (20004616)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. SATO Tatsusuke (00091611)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
7. CHIBA Mitsuru (20583735)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
8. MONZEN Satoru (20514136)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
9. YOSHINO Hironori (10583734)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
10. 田村真理 (20124604)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 安井明 (60191110)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 花田勝美 (80091627)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 松江一 (30106843)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 工藤一 (40003397)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. KITAJIMA Maiko

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. TOMISAWA Toshiko

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
17. 有吉健太郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
18. 柿崎育子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
19. 嵯峨涼

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
20. 奥村一彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
21. 七島直樹

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
22. 堀江香代

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Nakamura Toshiya 中村 敏也

NAKAMURA Toshiya 中村 敏也

中村 後也 ナカムラ トシヤ

中村 敏也 ナカムラ トシヤ

Research Projects

Research Products

Co-Researchers

Elucidation of the biological defense mechanism of chondroitin sulfate on the intestinal tractPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The development of novel internal radiation dosimetry using circulating exosomal RNAs into body fluids

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Adipokine regulation and antitumor effect by apple procyanidins

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Quantitative and qualitative control of hyaluronan which plays a role in the assembly of extracellular matrix as a backbone of proteoglycan aggregatePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Enzymatic Synthesis of Artificial Proteoglycans Having Reconstructed Sugar Chains

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Formation of hyaluronic-acid-deficient extracellular matrix induced by an inhibitor for hyaluronic acid synthesisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

細胞増殖の調節、癌細胞の形質保持における蛋白質ホスファタ-ゼの機能に関する研究

Principal Investigator

Project Period (FY)

Research Category

Research Institution

結合組織を形成しているヒアルロン酸の代謝とヒアルロン酸尿症に関する研究

Principal Investigator

Project Period (FY)

Research Category

Research Institution

[Journal Article] Radiation Safety and Public Health for Radiological Professionals: Meeting Report on The 5th Educational Symposium on Radiation and Health (ESRAH) by Young Scientists in 2018.2021

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Metal coordination by L-amino acid oxidase derived from flounder Platichthys stellatus is structurally essential and regulates antibacterial activity2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Phosphorylation of Thr328 in hyaluronan synthase 2 is essential for hyaluronan synthesis2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Dermatan sulfate oligosaccharides having reducing end 2, 5-anhydro-D-talose inhibit bovine testicular hyaluronidase activity2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Regulation of radiosensitivity by 4-methylumbelliferone via the suppression of interleukin‐1 in fibrosarcoma cells.2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Lessons From a Japan-Korea Collaboration on Medical Response Training for a Nuclear or Radiological Emergency, Assuming Mass Casualty2019

Author(s)

Nakamura Toshiya 中村敏也

NAKAMURA Toshiya 中村敏也

中村後也ナカムラトシヤ

中村敏也ナカムラトシヤ