SUGITA Masahiko 杉田昌彦

Researcher Number	80333532
Other IDs
Affiliation (based on the past Project Information) *help	2021 – 2023: 京都大学, 医生物学研究所, 教授 2016 – 2020: 京都大学, ウイルス・再生医科学研究所, 教授 2004 – 2015: 京都大学, ウイルス研究所, 教授 2008: ウイルス研究所, 教授 2001 – 2003: 日本医科大学, 医学部, 教授
Review Section/Research Field	Principal Investigator Biological Sciences / Infectious disease medicine / Biological Sciences / Basic Section 54030:Infectious disease medicine-related / Medium-sized Section 54:Internal medicine of the bio-information integration and related fields / 膠原病・アレルギー・感染症内科学 / Dermatology Except Principal Investigator Pathological medical chemistry / Living organism molecular science
Keywords	Principal Investigator 脂質 / リポペプチド / 免疫学 / CD1 / ワクチン / MHC / 細胞・組織 / 結核 / 結核菌 / 抗原提示 … More / ウイルス / エイズ / 脂質抗原 / 脂質免疫 / 感染症 / 細菌 / トランスジェニックマウス / BCG / 自己免疫 / 感染症防御学 / キラーT細胞 / 糖脂質 / 癌 / 生体分子 / T細胞 / 免疫応答 / 樹状細胞 / 感染防御 / HLA / 細胞傷害性T細胞 / 免疫 / 結晶構造 / MHC分子 / 生体防御 / 好中球 / マクロファージ / 脂質ワクチン / vaccine / Mycobacterium tuberculosis / lipid / モルモット / 免疫制御 / 感染症学 / CD1a分子 / 癌免疫 / 抗体 / 獲得免疫 / 抗酸菌 … More Except Principal Investigator 癌 / 感染症 / S100 / 慢性炎症病態 / 結核 / 免疫学 / がん / マクロファージ / 好中球 / 慢性炎症 / ミコール酸糖脂質 / 脂質 / 細菌 / 酵素 / ミコール酸 / 生理活性 / 脂質合成酵素 / 生物活性 / 生合成 / ミコール酸転移酵素 / 糖脂質 / マイコバクテリア Less

New vaccine strategies by the use of lipid immunityPrincipal Investigator
- Principal Investigator
  
  杉田昌彦
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 54030:Infectious disease medicine-related
- Research Institution
  Kyoto University
Identification of HLA class I molecules with the capacity of mediating lipopeptide presentationPrincipal Investigator
- Principal Investigator
  
  Sugita Masahiko
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 54:Internal medicine of the bio-information integration and related fields
- Research Institution
  Kyoto University
Basic mechanisms underlying lipopeptide antigen presentationPrincipal Investigator
- Principal Investigator
  
  杉田昌彦
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Kyoto University
Novel functions of human lipopeptide immunity in viral infection and autoimmunityPrincipal Investigator
- Principal Investigator
  
  Sugita Masahiko
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 54:Internal medicine of the bio-information integration and related fields
- Research Institution
  Kyoto University
Vaccine development against tuberculosis and AIDS by the use of lipid immunityPrincipal Investigator
- Principal Investigator
  
  Sugita Masahiko
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 54030:Infectious disease medicine-related
- Research Institution
  Kyoto University
Regulation of macrophages polarization by neutrophils: implication in tuberculosis and cancer pathology
- Principal Investigator
  
  Mizutani Tatsuaki
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Kyoto University
Generation and immune recognition of the novel antigen repertoire, lipopeptidesPrincipal Investigator
- Principal Investigator
  
  杉田昌彦
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Kyoto University
Identification of human lipopeptide-presenting molecules: a new host defense mechanism against viral infectionsPrincipal Investigator
- Principal Investigator
  
  SUGITA Masahiko
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Infectious disease medicine
- Research Institution
  Kyoto University
ウイルスタンパク質の翻訳後修飾を起点とした病原体宿主相克の機構解明と制御Principal Investigator
- Principal Investigator
  
  杉田昌彦
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Kyoto University
Lipid immunity in rhesus monkeys and development of a new anti-tuberculosis vaccinePrincipal Investigator
- Principal Investigator
  
  SUGITA Masahiko
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Infectious disease medicine
- Research Institution
  Kyoto University
Study of lipopeptide-specific immunity against AIDS: from monkeys to humansPrincipal Investigator
- Principal Investigator
  
  SUGITA, Masahiko
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Infectious disease medicine
- Research Institution
  Kyoto University
リポペプチドを提示するMHCクラス１分子の同定Principal Investigator
- Principal Investigator
  
  杉田昌彦
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Kyoto University
Development of a new type of anti-tuberculosis vaccines by the use of lipid immunityPrincipal Investigator
- Principal Investigator
  
  SUGITA Masahiko
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Infectious disease medicine
- Research Institution
  Kyoto University
Identification of cytotoxic T lymphocyte responses to lipopeptides in human immunodeficiency virus-infected patients.Principal Investigator
- Principal Investigator
  
  SUGITA Masahiko
- Project Period (FY)
  2012
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Infectious disease medicine
- Research Institution
  Kyoto University
MHCとCD1の機能連関による免疫制御の新戦略Principal Investigator
- Principal Investigator
  
  杉田昌彦
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Kyoto University
CD1/lipid immunity-based vaccines against AIDSPrincipal Investigator
- Principal Investigator
  
  SUGITA Masahiko
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Infectious disease medicine
- Research Institution
  Kyoto University
Developent of glycolipid vaccines against tuberculos isPrincipal Investigator
- Principal Investigator
  
  SUGITA Masahiko
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Infectious disease medicine
- Research Institution
  Kyoto University
がん糖脂質を標的にした免疫治療法の確立Principal Investigator
- Principal Investigator
  
  杉田昌彦
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Kyoto University
Functional analyses and modification of mycolyltransferases that involve in biosynthesis of various bio -active lipids.
- Principal Investigator
  
  MATSUNAGA Isamu
- Project Period (FY)
  2007 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Living organism molecular science
- Research Institution
  Kyoto University
がん糖脂質を標的にした免疫治療法の開発Principal Investigator
- Principal Investigator
  
  杉田昌彦
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Kyoto University
Development of a new class of lipid-based vaccines against tuberculosisPrincipal Investigator
- Principal Investigator
  
  SUGITA Masahiko
- Project Period (FY)
  2006 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  膠原病・アレルギー・感染症内科学
- Research Institution
  Kyoto University
ランゲルハンス細胞に発現したCD1a分子の新しい機能の解明Principal Investigator
- Principal Investigator
  
  杉田昌彦
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Dermatology
- Research Institution
  Kyoto University
脂質に応答するCD1依存性獲得免疫の成立基盤の解明とその賦活法の開発Principal Investigator
- Principal Investigator
  
  杉田昌彦
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Kyoto University
グループ1CD1トランスジエニックマウスを用いた結核菌感染防御生体反応の解析Principal Investigator
- Principal Investigator
  
  杉田昌彦
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Kyoto University
自己脂質および細菌脂質に応答する、CD1依存性獲得免疫システムの構築基盤の解明Principal Investigator
- Principal Investigator
  
  杉田昌彦
- Project Period (FY)
  2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Kyoto University
結核菌脂質をターゲットにした免疫応答とその制御Principal Investigator
- Principal Investigator
  
  杉田昌彦
- Project Period (FY)
  2003
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Nippon Medical School
New anti-tuberculosis vaccine strategies by the use of the CD1-lipid antigen presentation pathwayPrincipal Investigator
- Principal Investigator
  
  SUGITA Masahiko
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  膠原病・アレルギー・感染症内科学
- Research Institution
  Kyoto University
  Nippon Medical School
病原性及び非病原性結核菌感染防御における、CD1を介した脂質抗原提示の重要性Principal Investigator
- Principal Investigator
  
  杉田昌彦
- Project Period (FY)
  2002
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Nippon Medical School
結核菌感染樹状細胞における、CD1分子を介した脂質抗原提示経路の解明Principal Investigator
- Principal Investigator
  
  杉田昌彦
- Project Period (FY)
  2001
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Nippon Medical School

[Journal Article] Engagement with the TCR induces plasticity in antigenic ligands bound to MHC class I and CD1 molecules2023
- Author(s)
  Daisuke Morita, Minori Asa, Masahiko Sugita
- Journal Title
  
  International Immunology
  
  Volume: 35 Issue: 1 Pages: 7-17
- DOI
  10.1093/intimm/dxac046
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K07078, KAKENHI-PROJECT-21H02968, KAKENHI-PROJECT-20J23335, KAKENHI-PROJECT-20K21615
[Journal Article] Crystal structures of N-myristoylated lipopeptide-bound HLA class I complexes indicate reorganization of B-pocket architecture upon ligand binding2022
- Author(s)
  Minori Asa, Daisuke Morita, Jin Kuroha, Tatsuaki Mizutani, Naoki Mori, Bunzo Mikami, Masahiko Sugita
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 298 Issue: 7 Pages: 102100-102100
- DOI
  10.1016/j.jbc.2022.102100
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K07078, KAKENHI-PROJECT-22K05441, KAKENHI-PROJECT-21H02968, KAKENHI-PROJECT-20J23335, KAKENHI-PROJECT-20K21615
[Journal Article] Crystal structure of the ternary complex of TCR, MHC class I and lipopeptides.2020
- Author(s)
  Morita D, Iwashita C, Mizutani T, Mori N, Mikami B, Sugita M.
- Journal Title
  
  International Immunology
  
  Volume: 32 Issue: 12 Pages: 805-810
- DOI
  10.1093/intimm/dxaa050
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-19H04805, KAKENHI-PROJECT-18H02852, KAKENHI-PROJECT-18K07172
[Journal Article] Crystal structures of lysophospholipid-bound MHC class I molecules2020
- Author(s)
  Shima Yoko、Morita Daisuke、Mizutani Tatsuaki、Mori Naoki、Mikami Bunzo、Sugita Masahiko
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: in press Issue: 20 Pages: 6983-6991
- DOI
  10.1074/jbc.ra119.011932
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K07172, KAKENHI-PUBLICLY-19H04805, KAKENHI-PROJECT-18H02852, KAKENHI-PROJECT-18K19563
[Journal Article] Identification and Structure of an MHC Class I-Encoded Protein with the Potential to Present N-Myristoylated 4-mer Peptides to T Cells2019
- Author(s)
  Yamamoto Y, Morita D, Shima Y, Midorikawa A, Mizutani T, Suzuki J, Mori N, Shiina T, Inoko H, Tanaka Y, Mikami B, Sugita M.
- Journal Title
  
  Journal of Immunology
  
  Volume: 202 Issue: 12 Pages: 3349-3358
- DOI
  10.4049/jimmunol.1900087
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K19563, KAKENHI-PUBLICLY-17H05791, KAKENHI-PROJECT-18H02852, KAKENHI-PROJECT-18K07172, KAKENHI-PLANNED-16H06502
[Journal Article] 結核菌脂質の特徴と機能2017
- Author(s)
  藤原永年、杉田昌彦
- Journal Title
  
  結核
  
  Volume: 改訂版 Pages: 98-121
- Data Source
  KAKENHI-PROJECT-15H04869
[Journal Article] 肉芽腫形成を制御するS100A9陽性好中球2017
- Author(s)
  水谷龍明、杉田昌彦
- Journal Title
  
  医学のあゆみ
  
  Volume: 263 Pages: 671-672
- Data Source
  KAKENHI-PROJECT-15H04869
[Journal Article] Lipopeptides: a novel antigen repertoire presented by major histocompatibility complex class I molecules2016
- Author(s)
  Morita D, Sugita M
- Journal Title
  
  Immunology
  
  Volume: 149 Issue: 2 Pages: 139-145
- DOI
  10.1111/imm.12646
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PUBLICLY-15H01257, KAKENHI-PROJECT-16K15517
[Journal Article] Neutrophils and the S100A9 protein critically regulate granuloma formation2016
- Author(s)
  Yuya Yoshioka, Tatsuaki Mizutani, Satoshi Mizuta, Ayumi Miyamoto, Satoru Murata, Toshiaki Ano, Hiroshi Ichise, Daisuke Morita, Hiroyuki Yamada, Yoshihiko Hoshino, Tatsuaki Tsuruyama and Masahiko Sugita
- Journal Title
  
  Blood Advances
  
  Volume: 1 Issue: 3 Pages: 184-192
- DOI
  10.1182/bloodadvances.2016000497
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15H04869, KAKENHI-PROJECT-26713041, KAKENHI-PROJECT-16K19151
[Journal Article] Crystal structure of the N-myristoylated lipopeptide-bound MHC class I complex.2015
- Author(s)
  Morita D, Yamamoto Y, Mizutani T, Ishikawa T, Suzuki J, Igarashi T, Mori N, Shiina T, Inoko H, Fujita H, Iwai K, Tanaka Y, Mikami B, Sugita M,
- Journal Title
  
  Nat Commun.
  
  Volume: 7 Issue: 1 Pages: 10356-10356
- DOI
  10.1038/ncomms10356
- NAID
  120005743661
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K19007, KAKENHI-PUBLICLY-15H01257, KAKENHI-PROJECT-26670483, KAKENHI-PROJECT-26860323, KAKENHI-PLANNED-24120006
[Journal Article] Glycerol monomycolate is a novel ligand for the human, but not mouse macrophage inducible C-type lectin, Mincle.2014
- Author(s)
  Hattori Y, Morita, D, Fujiwara N, Mori D, Nakamura T, Harashima H, Yamasaki S, Sugita M.
- Journal Title
  
  The Journal of Biological Chemistry
  
  Volume: 289(22) Issue: 22 Pages: 15405-12
- DOI
  10.1074/jbc.m114.566489
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-12J04754, KAKENHI-PROJECT-14J03573, KAKENHI-PROJECT-24390255, KAKENHI-PROJECT-25460543, KAKENHI-PLANNED-26110009, KAKENHI-PROJECT-26293099, KAKENHI-PROJECT-26670213, KAKENHI-PROJECT-26860323
[Journal Article] Molecular requirements for T cell recognition of N-myristoylated peptides derived form the simian immunodeficiency virus Nef protein.2013
- Author(s)
  Morita D, et al.
- Journal Title
  
  Journal of Virology
  
  Volume: 87 Issue: 1 Pages: 482-488
- DOI
  10.1128/jvi.02142-12
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-12J05233, KAKENHI-PROJECT-22380068, KAKENHI-PROJECT-24659481, KAKENHI-PLANNED-24120006
[Journal Article] Th1-skewed tissue responses to a mycolyl glycolipid in mycobacteria-infected rhesus macaques.2013
- Author(s)
  Morita D, Miyamoto A, Hattori Y, Komori T, Nakamura T, lgarashi T, Harashima H, Sugita M
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 441(1) Issue: 1 Pages: 108-113
- DOI
  10.1016/j.bbrc.2013.10.021
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-12J04754, KAKENHI-PROJECT-24390255
[Journal Article] New insights into lipidic secondary metabolites in Mycobacteria2011
- Author(s)
  Matsunaga I, Sugita M
- Journal Title
  
  Curr.Chem.Biol.
  
  Volume: 5巻 Pages: 52-63
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390304
[Journal Article] Cutting edge : T cells monitor N-myristoylation of the Nef protein in simian immunodeficiency virus-infected monkeys2011
- Author(s)
  Morita D, Igarashi T, Horiike M, Mori N, Sugita M.
- Journal Title
  
  J. Immunol
  
  Volume: 187(2) Pages: 608-612
- Data Source
  KAKENHI-PROJECT-22659188
[Journal Article] Glycerol monomycolate, a latent tuberculosis-associated mycobacterial lipid, induces eosinophilic hypersensitivity responses in guinea pigs. Biochem2011
- Author(s)
  Hattori Y, Matsunaga I, Komori T, UrakawaT, Nakamura T, Fujiwara N, Hiromatsu K, Harashima H, Sugita M.
- Journal Title
  
  Biophys. Res. Commun
  
  Volume: 409(2) Pages: 304-307
- Data Source
  KAKENHI-PROJECT-21390304
[Journal Article] A microbial glycolipid functions as a new class of target antigen for delayed-type hypersensitivity2011
- Author(s)
  Komori T, Nakamura T, Matsunaga I, Morita D, Hattori Y, Kuwata H, Fujiwara N, Hiromatsu K, Harashima H, Sugita M.
- Journal Title
  
  J. Biol. Chem
  
  Volume: 286(19) Pages: 16800-16806
- Data Source
  KAKENHI-PROJECT-21390304
[Journal Article] Mycolyltransferase from Mycobacterium leprae excludes mycolate-containing glycolipid substrates.2009
- Author(s)
  Nakao H, Matsunaga I, Morita D, Aboshi T, Harada T, Nakagawa Y, Mori N, Sugita M
- Journal Title
  
  J. Biochem 146
  
  Pages: 659-665
- NAID
  10026304557
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19510216
[Journal Article] Trehalose dimycolate elicits eosinophilic skin hypersensitivity in mycobacteria-infected Guinea pigs.2008
- Author(s)
  Otsuka A, Matsunaga I, Komori T, Tomita K, Toda Y, Manabe T, Miyachi Y, Sugita M
- Journal Title
  
  J. Immunol 181
  
  Pages: 8528-8533
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19510216
[Journal Article] Identification of antibody responses to the serotype-nonspecific molecular species of glycopeptidolipids in Mycobacterium avium infection2008
- Author(s)
  Matsunaga I, Komori T, Ochi A, Mori N, Sugita M
- Journal Title
  
  Biochem. Biophys. Res. Commun 377
  
  Pages: 165-169
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390289
[Journal Article] Mycolyltransferase-mediated Glycolipid Exchange in Mycobacteria.2008
- Author(s)
  Matsunaga I, Naka T, Talekar RS, McConnell MJ, Katoh K, Nakao H, Otsuka A, Behar SM, Yano I, Moody DB, Sugita M.
- Journal Title
  
  J. Biol. Chem. 283
  
  Pages: 28835-28841
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19510216
[Journal Article] Trans-species activation of human T cells by rhesus macaque CD1b molecules2008
- Author(s)
  Morita D, Katoh K, Harada T, Nakagawa Y, Matsunaga I, Miura T, Adachi A, Igarashi T, Sugita M
- Journal Title
  
  Biochem. Biophys. Res. Commun 377
  
  Pages: 889-893
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390289
[Journal Article] Trehalose dimycolate elicits eosinophilic skin hypersensitivity in mycobacteria-infected guinea pigs2008
- Author(s)
  Otsuka A, Matsunaga I, Komori T, Tomita K, Toda Y, Manabe T, Miyachi Y, Sugita M
- Journal Title
  
  J. Immunol 181
  
  Pages: 8528-8533
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390289
[Journal Article] Mycolyltransferase-mediated glycolipid exchange in mycobacteria2008
- Author(s)
  Matsunaga I, Naka T, Talekar RS, McConnell MJ, Katoh K, Nakao H, Otsuka A, Behar SM, Yano I, Moody DB, Sugita M
- Journal Title
  
  J. Biol. Chem 283
  
  Pages: 28835-28841
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390289
[Journal Article] Trehalose dimycolate elicits eosinophilic skin hypersensitivity in mycobacteria-infected Guinea pigs.2008
- Author(s)
  Otsuka A, Matsunaga I, Komor T, Tomita K, Toda Y, Manabe T, Miyachi Y, Sugita M.
- Journal Title
  
  J. Immunol. 181
  
  Pages: 8528-8533
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19510216
[Journal Article] Evasion of peptide, but not lipid antigen presentation, through pathogen-induced dendritic cell maturation(USA)2008
- Author(s)
  Hava DL, van der Wel N, Cohen N, Dascher CC, Houben D, Leon L, Agarwal S, Sugita M, van Zon M, Kent SC, Shams H, Peters PJ, Brenner MB
- Journal Title
  
  Proc. Natl. Acad. Sci 105
  
  Pages: 11281-11286
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390289
[Journal Article] Pathways of CD1 and lipid antigen delivery, trafficking, processing, loading and presentation.2007
- Author(s)
  Sugita M, Barral DC, Brenner MB.
- Journal Title
  
  Current Topics in Microbiology and Immunology 314
  
  Pages: 143-164
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390289
[Journal Article] Lipid-specific immune responses against tuberculosis ; from basic science to medical applications. Curr2007
- Author(s)
  Matsunaga I, Sugita M
- Journal Title
  
  Immunol. Rev 3
  
  Pages: 145-150
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390289
[Journal Article] Pathways of CD1 and lipid antigen delivery, trafficking, processing, loading and presentation2007
- Author(s)
  Sugita M, Barral DC, Brenner MB
- Journal Title
  
  Curr. Top. Microbiol. Immunol 314
  
  Pages: 143-164
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390289
[Journal Article] Pathways of CD1 and lipid antigen delivery, trafficking, processing, loading and presentation.2007
- Author(s)
  Sugita M, Barral DC, Brenner MB
- Journal Title
  
  Current Topics in Microbiology and Immunology (印刷中)
- Data Source
  KAKENHI-PROJECT-18390289
[Journal Article] Lipid-specific immune responses against tuberculosis: from basic science to medical applications.2007
- Author(s)
  Matsunaga I, Sugita M.
- Journal Title
  
  Current Immunology Reviews 3
  
  Pages: 145-150
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390289
[Journal Article] Pathways of CD1 and lipid antigen delivery, trafficking, processing, loading and presentation.2007
- Author(s)
  Sugita M, Barral DC, Brenner MB
- Journal Title
  
  Current Topics in Microbiology and Immunology (印刷中)
- Data Source
  KAKENHI-PROJECT-17047023
[Journal Article] Pathways of CD1 and lipid antigen delivery, trafficking, processing, loading and presentation.2007
- Author(s)
  Sugita M, Barral DC, Brenner MB.
- Journal Title
  
  Current Topics in Microbiology and Immunology 314
  
  Pages: 143-164
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18015029
[Journal Article] Pathways of CD1 and lipid antigen delivery, trafficking, processing, loading and presentation.2007
- Author(s)
  Sugita M, Barral DC, Brenner MB
- Journal Title
  
  Current Topics in Microbiology and Immunology (印刷中)
- Data Source
  KAKENHI-PROJECT-18015029
[Journal Article] Pathways of CD1 and lipid antigen delivery, trafficking, processing, loading and presentation.2007
- Author(s)
  Sugita M, Barral DC, Brenner MB
- Journal Title
  
  Current Topics in Microbiology and Immunology (印刷中)
- Data Source
  KAKENHI-PROJECT-18659323
[Journal Article] Pathways of CD1 and lipid antigen delivery, trafficking, processing, loading and presentation.2007
- Author(s)
  Sugita M, Barral DC, Brenner MB.
- Journal Title
  
  Current Topics in Microbiology and Immunology 314
  
  Pages: 143-164
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18659323
[Journal Article] 結核菌脂質成分に対する免疫応答の分子機序2006
- Author(s)
  杉田昌彦
- Journal Title
  
  日本細菌学雑誌 61巻
  
  Pages: 405-413
- NAID
  10018643592
- Data Source
  KAKENHI-PROJECT-18390289
[Journal Article] New insights into pathways for CD1-mediated antigen presentation2004
- Author(s)
  Sugita M, et al.
- Journal Title
  
  Current Opinion in Immunology 16巻・1号
  
  Pages: 90-95
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390317
[Journal Article] New insights into pathways for CD1-mediated antigen presentation2004
- Author(s)
  Sugita M, et al.
- Journal Title
  
  Current Opinion in Immunology 16(1)
  
  Pages: 90-95
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390317
[Presentation] A molecular basis for specific recognition of lipopeptides by TCRs2022
- Author(s)
  Daisuke Morita, Masahiko Sugita
- Organizer
  日本免疫学会
- Data Source
  KAKENHI-PROJECT-21H02968
[Presentation] リポペプチドを提示するMHCクラスI分子の構造と機能2022
- Author(s)
  麻実乃莉、森田大輔、杉田昌彦
- Organizer
  日本生体防御学会
- Data Source
  KAKENHI-PROJECT-21H02968
[Presentation] Dynamic B-pocket remodeling is a basis for HLA class I molecules to bind peptides and lipopeptides2022
- Author(s)
  Minori Asa, Daisuke Morita, Masahiko Sugita
- Organizer
  日本免疫学会
- Data Source
  KAKENHI-PROJECT-20K21615
[Presentation] A molecular basis for specific recognition of lipopeptides by TCRs2022
- Author(s)
  Daisuke Morita, Masahiko Sugita
- Organizer
  日本免疫学会
- Data Source
  KAKENHI-PROJECT-20K21615
[Presentation] Dynamic B-pocket remodeling is a basis for HLA class I molecules to bind peptides and lipopeptides2022
- Author(s)
  Minori Asa, Daisuke Morita, Masahiko Sugita
- Organizer
  日本免疫学会
- Data Source
  KAKENHI-PROJECT-21H02968
[Presentation] リポペプチドを提示するMHCクラスI分子の構造と機能2022
- Author(s)
  麻実乃莉、森田大輔、杉田昌彦
- Organizer
  日本生体防御学会
- Data Source
  KAKENHI-PROJECT-20K21615
[Presentation] Crystal structure of the ternary complex of TCR, MHC class I and lipopeptides.2021
- Author(s)
  Morita D, and Sugita M.
- Organizer
  The 50th Annual Meeting of the Japanese Society for Immunology
- Data Source
  KAKENHI-PROJECT-20K21615
[Presentation] Crystal structure of the ternary complex of TCR, MHC class I and lipopeptides.2021
- Author(s)
  Morita D, and Sugita M.
- Organizer
  The 50th Annual Meeting of the Japanese Society for Immunology
- Data Source
  KAKENHI-PROJECT-21H02968
[Presentation] 霊長類研究から見えてきた、非ペプチド抗原を標的とする新しい獲得免疫機構2018
- Author(s)
  森田大輔、嶋燿子、杉田昌彦
- Organizer
  第29回日本生体防御学会学術総会
- Invited
- Data Source
  KAKENHI-PUBLICLY-17H05791
[Presentation] リポペプチドを提示するMHC class 1 分子の内因性リガンドの同定2018
- Author(s)
  嶋燿子、森田大輔、杉田昌彦
- Organizer
  第29回日本生体防御学会学術集会
- Data Source
  KAKENHI-PROJECT-18K19563
[Presentation] 肉芽腫形成を制御するS100A92018
- Author(s)
  水谷龍明、吉岡佑弥、杉田昌彦
- Organizer
  第29回日本生体防御学会学術総会
- Data Source
  KAKENHI-PROJECT-18H02852
[Presentation] 肉芽腫形成を制御するS100A92018
- Author(s)
  水谷龍明、吉岡佑弥、杉田昌彦
- Organizer
  第29回日本生体防御学会学術総会
- Data Source
  KAKENHI-PROJECT-17K08659
[Presentation] リポペプチドを提示するMHC class 1 分子の内因性リガンドの同定2018
- Author(s)
  嶋燿子、森田大輔、杉田昌彦
- Organizer
  第29回日本生体防御学会学術集会
- Data Source
  KAKENHI-PUBLICLY-17H05791
[Presentation] 霊長類研究から見えてきた、非ペプチド抗原を標的とする新しい獲得免疫機構2018
- Author(s)
  森田大輔、嶋燿子、杉田昌彦
- Organizer
  第29回日本生体防御学会学術総会
- Invited
- Data Source
  KAKENHI-PROJECT-18H02852
[Presentation] 霊長類研究から見えてきた、非ペプチド抗原を標的とする新しい獲得免疫機構2018
- Author(s)
  森田大輔、嶋燿子、杉田昌彦
- Organizer
  第29回日本生体防御学会学術総会
- Data Source
  KAKENHI-PROJECT-18K19563
[Presentation] リポペプチドを提示するMHC class 1 分子の内因性リガンドの同定2018
- Author(s)
  嶋燿子、森田大輔、杉田昌彦
- Organizer
  第29回日本生体防御学会学術集会
- Data Source
  KAKENHI-PROJECT-18H02852
[Presentation] Lipopeptides and phospholipids comprise a novel antigen repertoire presented by classical MHC class I molecules.2017
- Author(s)
  Shima, Y., Morita, D., and Sugita, M.
- Organizer
  12th International Symposium of the Institute Network
- Data Source
  KAKENHI-PROJECT-16K15517
[Presentation] Lipopeptides and phospholipids comprise a novel antigen repertoire presented by classical MHC class I molecules.2017
- Author(s)
  Shima, Y., Morita, D., and Sugita, M.
- Organizer
  12th International Symposium of the Institute Network
- Data Source
  KAKENHI-PUBLICLY-17H05791
[Presentation] 結核肉芽腫形成を制御する好中球機能の解明2017
- Author(s)
  水谷龍明、吉岡佑弥、大内結貴、森田大輔、杉田昌彦
- Organizer
  2017年度生命科学系学会合同年次大会
- Data Source
  KAKENHI-PROJECT-17K08659
[Presentation] 結核肉芽腫形成を制御する好中球機能の解明2017
- Author(s)
  水谷龍明、吉岡佑弥、大内結貴、森田大輔、杉田昌彦
- Organizer
  生命科学系学会合同年次大会（第40回日本分子生物学会、第90回日本生化学会）
- Data Source
  KAKENHI-PROJECT-15H04869
[Presentation] 「リポペプチド免疫応答」の発見とその分子機構の解明2016
- Author(s)
  森田大輔、杉田昌彦
- Organizer
  第27回日本生体防御学会学術集会
- Place of Presentation
  福岡
- Year and Date
  2016-07-07
- Invited
- Data Source
  KAKENHI-PROJECT-16K15517
[Presentation] 「リポペプチド免疫応答」の発見とその分子機構の解明2016
- Author(s)
  森田大輔、杉田昌彦
- Organizer
  第27回日本生体防御学会学術集会
- Place of Presentation
  福岡
- Year and Date
  2016-07-07
- Invited
- Data Source
  KAKENHI-PUBLICLY-15H01257
[Presentation] 脂質免疫：結核菌やエイズウイルスに対抗する新しい獲得免疫システム2015
- Author(s)
  杉田昌彦
- Organizer
  第89回日本感染症学会学術講演会
- Place of Presentation
  京都
- Year and Date
  2015-04-16
- Invited
- Data Source
  KAKENHI-PUBLICLY-15H01257
[Presentation] 脂質免疫：結核菌やエイズウイルスに対抗する新しい獲得免疫システム2015
- Author(s)
  杉田昌彦
- Organizer
  第89回日本感染症学会学術講演会
- Place of Presentation
  京都
- Year and Date
  2015-04-16
- Invited
- Data Source
  KAKENHI-PROJECT-26670483
[Presentation] 脂質免疫：結核菌やエイズウイルスに対抗する新しい獲得免疫システム2015
- Author(s)
  杉田昌彦
- Organizer
  第89回日本感染症学会学術講演会
- Place of Presentation
  京都
- Year and Date
  2015-04-16
- Invited
- Data Source
  KAKENHI-PROJECT-15H04869
[Presentation] Lipopeptide Ag presentation by MHC class I molecules: evidence from SIV-infected monkeys2013
- Author(s)
  Morita D, Sugita M.
- Organizer
  日本免疫学会総会
- Place of Presentation
  千葉
- Data Source
  KAKENHI-PUBLICLY-25133704
[Presentation] ウイルス蛋白質のミリスチン酸修飾を検知する新たなT細胞応答2012
- Author(s)
  森田大輔、五十嵐樹彦、森直樹、杉田昌彦
- Organizer
  第23回日本生体防御学会学術集会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24659481
[Presentation] Nef蛋白質のミリスチン酸修飾をモニターする新たな免疫システム2011
- Author(s)
  森田大輔、五十嵐樹彦、堀池麻理子、森直樹、杉田昌彦
- Organizer
  第25回日本エイズ学会学術集会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-22659188
[Presentation] ミコール酸含有糖脂質の生合成と免疫認識~抗酸菌バイオロジーの新たな世界2010
- Author(s)
  杉田昌彦
- Organizer
  第85回日本結核病学会学術集会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-21390304
[Presentation] 結核菌脂質を標的とした新しい免疫応答2010
- Author(s)
  杉田昌彦
- Organizer
  第53回日本感染症学会中日本地方会学術総会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-21390304
[Presentation] らい菌のミコール酸転移酵素によるミコール酸糖脂質合成2009
- Author(s)
  松永勇, 中尾瞳, 森田大輔, 杉田昌彦
- Organizer
  第82回日本生化学会大会
- Place of Presentation
  神戸国際展示場
- Year and Date
  2009-10-22
- Data Source
  KAKENHI-PROJECT-19510216
[Presentation] ミコール酸転移酵素による脂質T細胞抗原の生合成2008
- Author(s)
  松永勇、中崇、加藤久美子、中尾瞳、大塚篤司、矢野郁也、杉田昌彦
- Organizer
  第81回日本生化学会総会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-18390289
[Presentation] Eosinophilic skin reactions to glycolipids in mycobacterial infection represent a novel form of delayed-type hypersensitivity2008
- Author(s)
  Otsuka A, Matsunaga I, Komori T, Tomita K, Toda Y, Manabe T, Miyachi Y, Sugita M
- Organizer
  The International Investigative Dermatology 2008
- Place of Presentation
  Kyoto
- Data Source
  KAKENHI-PROJECT-18390289
[Presentation] Eosinophilic skin reactions to glycolipids define a novel form of hypersensitivity in mycobacterial infection2008
- Author(s)
  Otsuka A, Matsunaga I, Miyachi Y, Sugita M
- Organizer
  第38回日本免疫学会総会
- Place of Presentation
  国立京都国際会館
- Year and Date
  2008-12-01
- Data Source
  KAKENHI-PROJECT-19510216
[Presentation] ミコール酸転移酵素による脂質T細胞抗原の生合成2008
- Author(s)
  松永勇, 中崇, 加藤久美子, 中尾瞳, 大塚篤司, 矢野郁也, 杉田昌彦
- Organizer
  第81回日本生化学会大会
- Place of Presentation
  神戸・神戸国際展示場
- Year and Date
  2008-12-04
- Data Source
  KAKENHI-PROJECT-19510216
[Presentation] ミコール酸転移酵素による脂質T細胞抗原の生合成2008
- Author(s)
  松永勇, 中崇, 加藤久美子, 中尾瞳, 大塚篤司, 矢野郁也, 杉田昌彦
- Organizer
  第81回日本生化学会大会
- Place of Presentation
  神戸国際展示場
- Year and Date
  2008-12-14
- Data Source
  KAKENHI-PROJECT-19510216
[Presentation] Eosinophilic skin reactions to glycolipids define a novel form of hypersensitivity in mycobacterial infection2008
- Author(s)
  Otsuka A, Matsunaga I, Miyachi Y, Sugita M
- Organizer
  第38回日本免疫学会総会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-18390289
[Presentation] Eosinophilic skin reactions to glycolipids define a novel form of hypersensitivity in mycobacterial infection2008
- Author(s)
  Otsuka A, Matsunaga I, Miyachi Y, Sugita M
- Organizer
  第38回日本免疫学会総会
- Place of Presentation
  京都・国立京都国際会館
- Year and Date
  2008-12-01
- Data Source
  KAKENHI-PROJECT-19510216
[Presentation] 感染防御と脂質免疫2007
- Author(s)
  杉田昌彦
- Organizer
  第81回日本感染症学会教育講演
- Place of Presentation
  京都
- Year and Date
  2007-04-10
- Data Source
  KAKENHI-PROJECT-18390289
[Presentation] 脂質免疫：結核菌やエイズウイルスに対抗する新しい獲得免疫システム
- Author(s)
  杉田昌彦
- Organizer
  第89回日本感染症学会総会
- Place of Presentation
  京都
- Year and Date
  2015-04-16 – 2015-04-17
- Invited
- Data Source
  KAKENHI-PUBLICLY-25133704
[Presentation] 脂質免疫：結核菌やエイズウイルスに対抗する新しい獲得免疫システム
- Author(s)
  杉田昌彦
- Organizer
  第89回日本感染症学会
- Place of Presentation
  京都
- Year and Date
  2015-04-16 – 2015-04-17
- Invited
- Data Source
  KAKENHI-PROJECT-26670483
[Presentation] 脂質免疫：結核菌やエイズウイルスに対抗する新しい獲得免疫システム
- Author(s)
  杉田昌彦
- Organizer
  第89回日本感染症学会総会
- Place of Presentation
  京都
- Year and Date
  2015-04-16 – 2015-04-17
- Invited
- Data Source
  KAKENHI-PROJECT-24390255

1. MATSUNAGA Isamu (00254425)

# of Collaborated Projects: 4 results

# of Collaborated Products: 21 results
2. IGARASHI Tatsuhiko (90467431)

# of Collaborated Projects: 3 results

# of Collaborated Products: 2 results
3. HIROMATSU Kenji (80252237)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. MORI Naoki (30293913)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
5. HARASHIMA Hideyoshi (00183567)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
6. NAKAMURA Takashi (20604458)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. TAKAORI Akifumi (20324626)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. Mizutani Tatsuaki (50701843)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
9. 宮地良樹 (30127146)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 森田大輔

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
11. 藤田宏明

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

SUGITA Masahiko 杉田 昌彦

Research Projects

Research Products

Co-Researchers

New vaccine strategies by the use of lipid immunityPrincipal Investigator

Principal Investigator

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Research Institution

Identification of HLA class I molecules with the capacity of mediating lipopeptide presentationPrincipal Investigator

Principal Investigator

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Review Section

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Basic mechanisms underlying lipopeptide antigen presentationPrincipal Investigator

Principal Investigator

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Review Section

Research Institution

Novel functions of human lipopeptide immunity in viral infection and autoimmunityPrincipal Investigator

Principal Investigator

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Review Section

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Vaccine development against tuberculosis and AIDS by the use of lipid immunityPrincipal Investigator

Principal Investigator

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Review Section

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Regulation of macrophages polarization by neutrophils: implication in tuberculosis and cancer pathology

Principal Investigator

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Research Institution

Generation and immune recognition of the novel antigen repertoire, lipopeptidesPrincipal Investigator

Principal Investigator

Project Period (FY)

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Research Institution

Identification of human lipopeptide-presenting molecules: a new host defense mechanism against viral infectionsPrincipal Investigator

Principal Investigator

Project Period (FY)

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Research Institution

ウイルスタンパク質の翻訳後修飾を起点とした病原体宿主相克の機構解明と制御Principal Investigator

Principal Investigator

Project Period (FY)

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Review Section

Research Institution

Lipid immunity in rhesus monkeys and development of a new anti-tuberculosis vaccinePrincipal Investigator

Principal Investigator

Project Period (FY)

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Research Field

Research Institution

Study of lipopeptide-specific immunity against AIDS: from monkeys to humansPrincipal Investigator

Principal Investigator

Project Period (FY)

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Research Field

Research Institution

リポペプチドを提示するMHCクラス１分子の同定Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of a new type of anti-tuberculosis vaccines by the use of lipid immunityPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

SUGITA Masahiko 杉田昌彦