Koinuma Daizo 鯉沼代造

… Alternative Names

KOINUMA Daizo 鯉沼代造

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Researcher Number	80375071
Other IDs
Affiliation (Current)	2024: 東京大学, 大学院医学系研究科(医学部), 准教授
Affiliation (based on the past Project Information) *help	2019 – 2024: 東京大学, 大学院医学系研究科(医学部), 准教授 2016 – 2017: 東京大学, 大学院医学系研究科(医学部), 准教授 2015: 東京大学, 大学院医学系研究科, 准教授 2012 – 2015: 東京大学, 医学(系)研究科(研究院), 准教授 2009 – 2011: Japanese Foundation For Cancer Research, 大学院・医学系研究科, 講師 … More 2008: Japanese Foundation For Cancer Research, 生化学部, 研究員 2007: Japanese Foundation For Cancer Research, 癌研究所・生化学部, 研究員 2006: (財)癌研究会, 癌研究所生化学部, 研究員 Less
Review Section/Research Field	Principal Investigator Respiratory organ internal medicine / Basic Section 50010:Tumor biology-related / Basic Section 53030:Respiratory medicine-related / Tumor biology / Tumor biology Except Principal Investigator Basic Section 49020:Human pathology-related / Complex systems / General medical chemistry / Biological Sciences / Biological Sciences
Keywords	Principal Investigator シグナル伝達 / 癌 / TGF-β / ChIP-seq / 転写因子 / TGF-beta / ゲノム / 発現制御 / 発生・分化 / 細胞・組織 … More / 変異 / ホットスポット変異 / SMAD4 / 大腸がん / 胃がん / 肺障害 / 血管内皮細胞 / マウスモデル / 肺線維症 / がん / スキルス胃がん / オープンクロマチン / RNA-seq / FAIRE / lincRNA / lncRNA / アポトーシス / ZEB1 / 乳がん / EMT / FAIRE-seq / 循環器・高血圧 / 病理学 / 内科 / 発生・文化 … More Except Principal Investigator シグナル伝達 / 発生・分化 / 血管新生 / 転移 / がん幹細胞 / TGF-β / 胎児形質 / 胃癌 / 癌 / 発生医学 / 細胞内シグナル伝達 / ゲノム医化学 / 細胞医化学 / BMP / リンパ管新生 / がん浸潤 / 微小環境 / ゲノム科学 / 生体イメージング / 生体材料 / がん微小環境 / Smad7 / DDS / 乳がん / 膵臓がん / がん朝細胞 / 脳腫瘍 / 胃がん / シグナル伝逹 / 分子標的治療 Less

Molecular characterization of gastric carcinoma with a primitive phenotype
- Principal Investigator
  
  牛久哲男
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 49020:Human pathology-related
- Research Institution
  The University of Tokyo
胃がん・大腸がんにおいて変異SMAD4がもたらすエピゲノム制御異常と病態への関与Principal Investigator
- Principal Investigator
  
  鯉沼代造
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  The University of Tokyo
Role of a cell type-specific mechanism of TGF-beta signaling activation in lung fibrosisPrincipal Investigator
- Principal Investigator
  
  Koinuma Daizo
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53030:Respiratory medicine-related
- Research Institution
  The University of Tokyo
Molecular mechanisms of cell differentiation and diversity by TGF-beta family members
- Principal Investigator
  
  Miyazono Kohei
- Project Period (FY)
  2017 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Complex systems
- Research Institution
  The University of Tokyo
Changes in the binding regions of Smads downstream of TGF-beta signaling in diffuse type gastric cancersPrincipal Investigator
- Principal Investigator
  
  Koinuma Daizo
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Tumor biology
- Research Institution
  The University of Tokyo
Cistromic analysis of EMT regulators in breast cancer cellsPrincipal Investigator
- Principal Investigator
  
  KOINUMA Daizo
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Tumor biology
- Research Institution
  The University of Tokyo
Roles of BMP signaling in maintenance of cell stemness
- Principal Investigator
  
  MIYAZONO Kohei
- Project Period (FY)
  2012 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General medical chemistry
- Research Institution
  The University of Tokyo
ChIP-seq analysis of transcriptional regulation by BMP in relation to pulmonary hypertensionPrincipal Investigator
- Principal Investigator
  
  KOINUMA Daizo
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  The University of Tokyo
Effects of TGF-beta family on cancer microenvironment and strategies for cancer therapy
- Principal Investigator
  
  MIYAZONO Kohei
- Project Period (FY)
  2010 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
Role of lung cancer cells to fibrosis and regulation of TGF-beta signaling by EGFPrincipal Investigator
- Principal Investigator
  
  KOINUMA Daizo
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Japanese Foundation For Cancer Research
呼吸器悪性腫瘍におけるTGF-βシグナル調節性E3ユビキチンリガーゼの役割Principal Investigator
- Principal Investigator
  
  鯉沼代造
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Japanese Foundation For Cancer Research
Establishment of New Strategies for Treatment of Cancer Using TGF-beta Signaling
- Principal Investigator
  
  MIYAZONO Kohei
- Project Period (FY)
  2005 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo

[Journal Article] Genome-wide analysis of DNA methylation identifies the apoptosis-related gene UQCRH as a tumor suppressor in renal cancer2022
- Author(s)
  Kosuke Miyakuni, Jun Nishida, Daizo Koinuma, Genta Nagae, Hiroyuki Aburatani, Kohei Miyazono, Shogo Ehata
- Journal Title
  
  Molecular Oncology
  
  Volume: 16 Issue: 3 Pages: 732-749
- DOI
  10.1002/1878-0261.13040
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21J12321, KAKENHI-PROJECT-19K07684, KAKENHI-PLANNED-17H06326, KAKENHI-PROJECT-23K21431
[Journal Article] Systemic administration of monovalent follistatin-like 3-Fc-fusion protein increases muscle mass in mice2021
- Author(s)
  Ozawa T., Morikawa M., Morishita Y., Ogikubo K., Itoh F., Koinuma D., Nygren P.-A., Miyazono K.
- Journal Title
  
  iScience
  
  Volume: 24 Issue: 5 Pages: 102488-102488
- DOI
  10.1016/j.isci.2021.102488
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07683, KAKENHI-PROJECT-20K07430, KAKENHI-PLANNED-17H06326
[Journal Article] PRRX1 induced by BMP signaling decreases tumorigenesis by epigenetically regulating glioma‐initiating cell properties via DNA methyltransferase 3A2021
- Author(s)
  Tanabe Ryo、Miyazono Kohei、Todo Tomoki、Saito Nobuhito、Iwata Caname、Komuro Akiyoshi、Sakai Satoshi、Raja Erna、Koinuma Daizo、Morikawa Masato、Westermark Bengt、Heldin Carl‐Henrik
- Journal Title
  
  Molecular Oncology
  
  Volume: 16 Issue: 1 Pages: 269-288
- DOI
  10.1002/1878-0261.13051
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06829, KAKENHI-PLANNED-17H06326
[Journal Article] Epigenetic remodelling shapes inflammatory renal cancer and neutrophil-dependent metastasis2020
- Author(s)
  Nishida Jun、Momoi Yusaku、Miyakuni Kosuke、Tamura Yusuke、Takahashi Kei、Koinuma Daizo、Miyazono Kohei、Ehata Shogo
- Journal Title
  
  Nature Cell Biology
  
  Volume: 110 Issue: 4 Pages: 2063-2074
- DOI
  10.1038/s41556-020-0491-2
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07684, KAKENHI-ORGANIZER-17H06324, KAKENHI-PLANNED-17H06326
[Journal Article] The ALK-1/SMAD/ATOH8 axis attenuates hypoxic responses and protects against the development of pulmonary arterial hypertension2019
- Author(s)
  Morikawa M、Mitani Y、Holmborn K、Kato T、Koinuma D、Maruyama J、Vasilaki E、Sawada H、Kobayashi M、Ozawa T、Morishita i、Bessho Y、Maeda S、Ledin J、Aburatani H、Kageyama R、Maruyama K、Heldin C-H、Miyazono K
- Journal Title
  
  Science Signaling
  
  Volume: 12 Issue: 607 Pages: 607-607
- DOI
  10.1126/scisignal.aay4430
- NAID
  120006902530
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08192, KAKENHI-PROJECT-19K22433, KAKENHI-PLANNED-17H06326, KAKENHI-PUBLICLY-19H04782, KAKENHI-PROJECT-18H02451, KAKENHI-PROJECT-17K11075, KAKENHI-PROJECT-18K07841
[Journal Article] Intracellular and extracellular TGF-β signaling in cancer: some recent topics.2018
- Author(s)
  Kohei Miyazono, Yoko Katsuno, Daizo Koinuma, Shogo Ehata, Masato Morikawa
- Journal Title
  
  Frontiers of Medicine
  
  Volume: 12 Issue: 4 Pages: 387-411
- DOI
  10.1007/s11684-018-0646-8
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-ORGANIZER-17H06324, KAKENHI-PROJECT-15H05774, KAKENHI-PLANNED-17H06326
[Journal Article] Pancreatic tumor microenvironment confers highly malignant properties on pancreatic cancer cells2018
- Author(s)
  Takahashi K, Ehata S, Koinuma D, Morishita Y, Soda M, Mano H, Miyazono K.
- Journal Title
  
  Oncogene
  
  Volume: - Issue: 21 Pages: 2757-2772
- DOI
  10.1038/s41388-018-0144-0
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-17H06326, KAKENHI-PROJECT-15H05774
[Journal Article] Identification of a novel fusion gene HMGA2-EGFR in glioblastoma2017
- Author(s)
  Komuro Akiyoshi、Raja Erna、Iwata Caname、Soda Manabu、Isogaya Kazunobu、Yuki Keiko、Ino Yasushi、Morikawa Masato、Todo Tomoki、Aburatani Hiroyuki、Suzuki Hiromichi、Ranjit Melissa、Natsume Atsushi、Mukasa Akitake、Saito Nobuhito、Okada Hitoshi、Mano Hiroyuki、Miyazono Kohei、Koinuma Daizo
- Journal Title
  
  International Journal of Cancer
  
  Volume: 142 Issue: 8 Pages: 1627-1639
- DOI
  10.1002/ijc.31179
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K15641, KAKENHI-PLANNED-17H06326, KAKENHI-PROJECT-15H05774, KAKENHI-PROJECT-26253073, KAKENHI-PROJECT-16H05436, KAKENHI-PROJECT-15K06831, KAKENHI-PROJECT-17H04300, KAKENHI-PROJECT-26293321, KAKENHI-PROJECT-26830067
[Journal Article] RNA-binding motif protein 47 inhibits Nrf2 activity to suppress tumor growth in lung adenocarcinoma2016
- Author(s)
  Sakurai T, Isogaya K, Sakai S, Morikawa M, Morishita Y, Ehata S, Miyazono K, Koinuma D
- Journal Title
  
  Oncogene
  
  Volume: 印刷中 Issue: 38 Pages: 5000-5009
- DOI
  10.1038/onc.2016.35
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08393, KAKENHI-PLANNED-22112002, KAKENHI-ORGANIZER-22112001, KAKENHI-PROJECT-15J03695, KAKENHI-PROJECT-15H05774
[Journal Article] BMP Sustains Embryonic Stem Cell Self-Renewal through Distinct Functions of Different Kruppel-like Factors.2016
- Author(s)
  Morikawa M, Koinuma D, Mizutani A, Kawasaki N, Holmborn K, Sundqvist A, Tsutsumi S, Watabe T, Aburatani H, Heldin CH, Miyazono K.
- Journal Title
  
  Stem Cell Reports.
  
  Volume: 6 Issue: 1 Pages: 64-73
- DOI
  10.1016/j.stemcr.2015.12.004
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-24221011, KAKENHI-PROJECT-24390070
[Journal Article] The Arkadia-ESRP2 axis suppresses tumor progression: analyses in clear-cell renal cell carcinoma2016
- Author(s)
  Mizutani A, Koinuma D, Seimiya H, Miyazono K.
- Journal Title
  
  Oncogene
  
  Volume: - Issue: 27 Pages: 3514-3523
- DOI
  10.1038/onc.2015.412
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-22112002, KAKENHI-ORGANIZER-22112001, KAKENHI-PROJECT-26830066, KAKENHI-PROJECT-15H05774
[Journal Article] Smad4 Decreases the Population of Pancreatic Cancer-Initiating Cells through Transcriptional Repression of ALDH1A12015
- Author(s)
  Hoshino Y, Nishida J, Katsuno Y, Koinuma D, Aoki T, Kokudo N, Miyazono K, Ehata S.
- Journal Title
  
  American Journal of Pathology
  
  Volume: 印刷中 Issue: 5 Pages: 1457-1470
- DOI
  10.1016/j.ajpath.2015.01.011
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-ORGANIZER-22112001, KAKENHI-PLANNED-22112002
[Journal Article] EZH2 promotes progression of small cell lung cancer by suppressing the TGF-β-Smad-ASCL1 pathway2015
- Author(s)
  Fumihiko Murai, Daizo Koinuma, Aya Shinozaki-Ushiku, Masashi Fukayama, Kohei Miyaozono, Shogo Ehata
- Journal Title
  
  Cell Discovery
  
  Volume: 1 Issue: 1 Pages: 15026-15026
- DOI
  10.1038/celldisc.2015.26
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K08393, KAKENHI-PLANNED-22112002
[Journal Article] The Arkadia-ESRP2 axis suppresses tumor progression: Analyses in clear cell renal cell carcinoma2015
- Author(s)
  Mizutani A, Koinuma D, Seimiya H and Miyazono K.
- Journal Title
  
  Oncogene
  
  Volume: 印刷中
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24501311
[Journal Article] A Smad3 and TTF-1/NKX2-1 complex regulates Smad4-independent gene expression2014
- Author(s)
  Isogaya K, Koinuma D, Tsutsumi S, Saito RA, Miyazawa K, Aburatani H, Miyazono K.
- Journal Title
  
  Cell Research
  
  Volume: 24 Issue: 8 Pages: 994-1008
- DOI
  10.1038/cr.2014.97
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-ORGANIZER-22112001, KAKENHI-PROJECT-26461185, KAKENHI-PLANNED-22112002
[Journal Article] Transforming growth factor-β-induced lncRNA-Smad7 inhibits apoptosis of mouse breast cancer JygMC(A) cells2014
- Author(s)
  Arase M, Horiguchi K, Ehata S, Morikawa M, Tsutsumi S, Aburatani H, Miyazono K, Koinuma D.
- Journal Title
  
  Cancer Science
  
  Volume: 105 Issue: 8 Pages: 974-982
- DOI
  10.1111/cas.12454
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-13J05974, KAKENHI-ORGANIZER-22112001, KAKENHI-PROJECT-24221011, KAKENHI-PROJECT-24390070, KAKENHI-PROJECT-24501311, KAKENHI-PLANNED-22112002
[Journal Article] Genome-wide mechanisms of Smad binding2013
- Author(s)
  Morikawa M
- Journal Title
  
  Oncogene
  
  Volume: 32 Issue: 13 Pages: 1609-1615
- DOI
  10.1038/onc.2012.191
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22112002, KAKENHI-PROJECT-22790750, KAKENHI-PROJECT-24390070, KAKENHI-ORGANIZER-22112001
[Journal Article] TGF-β-induced epithelial-mesenchymal transition of A549 lung adenocarcinoma cells is enhanced by pro-inflammatory cytokines derived from RAW 264. 7 macrophage cells2012
- Author(s)
  Kawata M, Koinuma D, Ogami T, Umezawa K, Iwata C, Watabe T, and Miyazono K.
- Journal Title
  
  J Biochem
  
  Volume: 151(2) Pages: 205-216
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790750
[Journal Article] Tumor-promoting functions of transforming growth factor-βin progression of cancer2012
- Author(s)
  Miyazono K, Ehata S, Koinuma D
- Journal Title
  
  Ups J Med Sci
  
  Volume: 117(2) Pages: 143-152
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790750
[Journal Article] RB1CC1 protein positivelyregulates transforming growth factor-beta signaling through the modulation of Arkadia E3 ubiquitin ligase activity2011
- Author(s)
  Koinuma D, Shinozaki M, Nagano Y, Ikushima H, Horiguchi K, Goto K, Chano T, Saitoh M, Imamura T, Miyazono K, and Miyazawa K.
- Journal Title
  
  J Biol Chem
  
  Volume: 286(37) Pages: 32502-32512
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790750
[Journal Article] ChIP-seq reveals cell type-specific binding patterns of BMP-specific Smads and a novel binding motif2011
- Author(s)
  Morikawa M, Koinuma D, Tsutsumi S, Vasilaki E, Kanki Y, Heldin CH, Aburatani H, Miyazono K.
- Journal Title
  
  Nucleic Acids Res
  
  Volume: 39(20) Pages: 8712-8727
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790750
[Journal Article] Arkadia-beyond the TGF-β pathway2011
- Author(s)
  Miyazono K, Koinuma D
- Journal Title
  
  Journal of Biochemistry
  
  Volume: 149 Pages: 1-3
- NAID
  10030582535
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22112002
[Journal Article] TGF-β derives epithelial-mesenchymal transition through δEF1-mediated downregulation of ESRP2011
- Author(s)
  堀口華奈
- Journal Title
  
  Oncogene
  
  Volume: (掲載確定)(印刷中) Issue: 26 Pages: 3190-3201
- DOI
  10.1038/onc.2011.493
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-09J05735, KAKENHI-PROJECT-11F01113, KAKENHI-ORGANIZER-22112001, KAKENHI-PLANNED-22112002, KAKENHI-PROJECT-22249061, KAKENHI-PROJECT-22390052, KAKENHI-PROJECT-22790750, KAKENHI-PROJECT-23390202, KAKENHI-PROJECT-23659854
[Journal Article] Cell type-specific target selection by combinatorial binding of Smad2/3 proteins and hepatocyte nuclear factor 4 alpha in HepG2 cells2011
- Author(s)
  Mizutani A, Koinuma D, Tsutsumi S, Kamimura N, Morikawa M, Suzuki HI, Imamura T, Miyazono K, Aburatani H.
- Journal Title
  
  J Biol Chem
  
  Volume: 286(34) Pages: 29848-29860
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790750
[Journal Article] RB1CC1 protein positively regulates transforming growth factor-beta signaling through the modulation of Arkadia E3 ubiquitin ligase activity2011
- Author(s)
  Koinuma D
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 286 Issue: 37 Pages: 32502-32512
- DOI
  10.1074/jbc.m111.227561
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22112002, KAKENHI-PLANNED-22113004, KAKENHI-PROJECT-22390052, KAKENHI-PROJECT-23390148
[Journal Article] Context-dependent regulation of the expression of c-Ski protein by Arkadia in human cancer cells.2010
- Author(s)
  Nagano, Y., Koinuma, D., Miyazawa, K., Miyazono, K.
- Journal Title
  
  J. Biochem. 147(4)
  
  Pages: 545-554
- NAID
  10027875176
- Data Source
  KAKENHI-PROJECT-17016011
[Journal Article] TGF-βによる転写制御2010
- Author(s)
  鯉沼代造
- Journal Title
  
  医学のあゆみ
  
  Volume: 234 Pages: 900-905
- Data Source
  KAKENHI-PROJECT-22790750
[Journal Article] Promoter-wide analysis of Smad4 binding sites in human epithelial cells2009
- Author(s)
  Koinuma, D., et al.
- Journal Title
  
  Cancer Science 100
  
  Pages: 2133-2142
- NAID
  10027197070
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016011
[Journal Article] Chromatin immunoprecipitation on microarray analysis of Smad2/3 binding sites reveals roles of ETS1 and TFAP2A in transforming growth factorβsignaling.2009
- Author(s)
  Koinuma, D., Tsutsumi, S., Kamimura, N., Taniguchi, H., Miyazawa, K., Sunamura, M., Imamura, T., Miyazono, K., Aburatani, H.
- Journal Title
  
  Mol. Cell. Biol. 29(1)
  
  Pages: 172-186
- Data Source
  KAKENHI-PROJECT-17016011
[Journal Article] SKI and MEL1 cooperate to inhibit transforming growth factor-βsignal in gastric cancer cells.2009
- Author(s)
  Takahata, M., Inoue, Y., Tsuda, H., Imoto, I., Koinuma, D., Hayashi, M., Ichikura, T., Yamori, T., Nagasaki, K., Yoshida, M., Matsuoka, M., Morishita, K., Yuki, K., Hanyu, A., Miyazawa, K., Inazawa, J., Miyazono, K., Imamura T.
- Journal Title
  
  J. Biol. Chem. 284(5)
  
  Pages: 3334-3344
- Data Source
  KAKENHI-PROJECT-17016011
[Journal Article] Chromatin immunoprecipitation on microarray analysis of Smad2/3 binding sites reveals roles of ETS1 and TFAP2A in transforming growth factor beta signaling2009
- Author(s)
  Koinuma, D., et al.
- Journal Title
  
  Mol.Cell.Biol. 29
  
  Pages: 172-186
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016011
[Journal Article] Pin1 down-regulates transforming growth factor-beta (TGF-beta) signaling by inducing degradation of Smad proteins.2009
- Author(s)
  Nakano A, Koinuma D, Miyazawa K, Uchida T, Saitoh M, Kawabata M, Hanai J, Akiyama H, Abe M, Miyazono K, Matsumoto T, Imamura T
- Journal Title
  
  J Biol Chem. 284
  
  Pages: 6109-6115
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790580
[Journal Article] Promoter-wide analysis of Smad4 binding sites in human epithelial cells.2009
- Author(s)
  Koinuma, D., Tsutsumi, S., Kamimura, N., Imamura, T., Aburatani, H., Miyazono, K.
- Journal Title
  
  Cancer Sci. 100(11)
  
  Pages: 2133-2142
- NAID
  10027197070
- Data Source
  KAKENHI-PROJECT-17016011
[Journal Article] Arkadia induces degradation of SnoN and c-Ski to enhance TGF-βsignaling.2007
- Author(s)
  Nagano, Y., Mavrakis, K.J., Lee, K.L., Fujii, T., Koinuma, D., Sase, H., Yuki, K., Isogaya, K., Saitoh, M., Imamura, T., Episkopou, V., Miyazono, K., Miyazawa, K.
- Journal Title
  
  J. Biol. Chem. 282(28)
  
  Pages: 20492-20501
- Data Source
  KAKENHI-PROJECT-17016011
[Patent] TGFβ阻害機能を持つキメラタンパク質2014
- Inventor(s)
  渡部徹郎、宮園浩平、鯉沼代造、江幡正悟、赤津裕一
- Industrial Property Rights Holder
  日本化薬株式会社、国立大学法人東京大学
- Industrial Property Rights Type
  特許
- Filing Date
  2014-08-11
- Data Source
  KAKENHI-PLANNED-22112002
[Patent] 癌の予後を予測するための方法及びキット、癌治療薬のスクリーニング方法、癌細胞増殖抑制剤、並びに癌治療薬2014
- Inventor(s)
  宮園浩平、鯉沼代造、磯谷一暢、川﨑夏実
- Industrial Property Rights Holder
  国立大学法人東京大学
- Industrial Property Rights Type
  特許
- Filing Date
  2014-04-24
- Data Source
  KAKENHI-PLANNED-22112002
[Presentation] 腎細胞がんはDNAメチル化を介してアポトーシス耐性を獲得する（口演）2021
- Author(s)
  宮國昂介、西田純、鯉沼代造、江幡正悟、宮園浩平
- Organizer
  第80回日本癌学会学術総会（横浜、hybrid）
- Data Source
  KAKENHI-PLANNED-17H06326
[Presentation] Identification of genes and their regulatory mechanisms related to the metastasis of triple-negative breast cancer (Oral)2021
- Author(s)
  Ogikubo K, Tamura Y, Nishida J, Takahashi K, Morikawa M, Ehata S, Koinuma D, Miyazono K.
- Organizer
  第80回日本癌学会学術総会（横浜、hybrid）
- Data Source
  KAKENHI-PLANNED-17H06326
[Presentation] Molecular mechanism of neutrophil-dependent metastasis of inflammatory renal cancer (Symposium)2021
- Author(s)
  Ehata S, Nishida J, Miyakuni K, Koinuma D, Miyazono K.
- Organizer
  第80回日本癌学会学術総会（横浜、hybrid）
- Invited
- Data Source
  KAKENHI-PLANNED-17H06326
[Presentation] トリプルネガティブ乳がんTNBCの高悪性化に伴うエピゲノム変化と治療標的遺伝子の同定（口演：優秀演題賞）2021
- Author(s)
  荻窪一貴、田村佑介、西田純、高橋恵生、江幡正悟、鯉沼代造、宮園浩平
- Organizer
  第25回日本がん分子標的治療学会学術集会（online）
- Data Source
  KAKENHI-PLANNED-17H06326
[Presentation] BET阻害剤の炎症を標的とした腎がん転移抑制効果2019
- Author(s)
  西田純、桃井悠作、田村佑介、高橋恵生、鯉沼代造、江幡正悟、宮園浩平
- Organizer
  新学術領域研究「細胞社会ダイバーシティーの統合的解明と制御」第4回公開シンポジウム
- Data Source
  KAKENHI-PLANNED-17H06326
[Presentation] Targeting metastasis-associated inflammation in renal cancer by BET inhibitor2019
- Author(s)
  Nishida J, Tamura Y, Takahashi K, Koinuma D, Ehata S, Miyazono K.
- Organizer
  第78回日本癌学会学術総会
- Data Source
  KAKENHI-PLANNED-17H06326
[Presentation] Epigenetic remodeling of renal cancer cells in primary tumor microenvironment triggers neutrophil-dependent lung metastasis2018
- Author(s)
  Nishida J, Tamura Y, Takahashi K, Koinuma D, Ehata S, Miyazono K.
- Organizer
  第18回東京大学生命科学シンポジウム
- Data Source
  KAKENHI-PLANNED-17H06326
[Presentation] Integrated analysis of transcriptional regulation by Smads2017
- Author(s)
  Daizo Koinuma
- Organizer
  TGF-beta meeting, Uppsala, Sweden
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K06831
[Presentation] Dynamics of chromatin accessibility during TGF-beta-induced EMT of Ras-transformed mammary gland epithelial cells2015
- Author(s)
  Koinuma D, Arase M, Isogaya K, Nakaki R, Mizutani A, TsutsumiS, Aburatani H, Miyazono K
- Organizer
  第74回日本癌学会学術総会
- Place of Presentation
  名古屋国際会議場（愛知県名古屋市）
- Year and Date
  2015-10-08
- Data Source
  KAKENHI-PROJECT-15K06831
[Presentation] Genome-wide profiling of TGF-beta-related transcription factor footprints2015
- Author(s)
  Koinuma D
- Organizer
  TGF-beta meeting
- Place of Presentation
  Uppsala（Sweden）
- Year and Date
  2015-08-19
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K06831
[Presentation] Analysis of pancreatic microenvironment with an orthotopic injection model and in vivo bioluminescence imagine system2015
- Author(s)
  Ehata S, Takahashi K, Koinuma D, Miyazono K.
- Organizer
  日本癌学会シンポジウム／共同利用・共同研究拠点シンポジウム : がん幹細胞・微小環境・分子標的～がん進展制御への挑戦
- Place of Presentation
  石川県立音楽堂交流ホール（石川県・金沢市）
- Year and Date
  2015-01-21
- Data Source
  KAKENHI-PLANNED-22112002
[Presentation] 小細胞肺がんにおける TGF-β シグナルの機能解析2014
- Author(s)
  村井文彦、江幡正悟、鯉沼代造、牛久綾、深山正久、宮園浩平
- Organizer
  第73回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜（神奈川県・横浜市）
- Year and Date
  2014-09-25
- Data Source
  KAKENHI-PLANNED-22112002
[Presentation] Transforming growth factor-β-induced long non-coding RNA-Smad7 inhibits apoptosis of mouse breast cancer cells2014
- Author(s)
  荒瀬麻友、堀口華奈、江幡正悟、森川真大、堤修一、油谷浩幸、宮園浩平、鯉沼代造
- Organizer
  第14回東京大学生命科学シンポジウム
- Place of Presentation
  東京都文京区
- Data Source
  KAKENHI-PROJECT-24501311
[Presentation] Emerging regulatory mechanism of mTOR signaling by a novel TGF-β target gene (English Oral Session)2014
- Author(s)
  Kawasaki N, Isogaya K, Koinuma D, Ehata S, Miyazono K.
- Organizer
  第73回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜（神奈川県・横浜市）
- Year and Date
  2014-09-25
- Data Source
  KAKENHI-PLANNED-22112002
[Presentation] 肺線癌におけるTGF-β標的遺伝子RBM47の発現と作用機構の解析2014
- Author(s)
  櫻井翼、鯉沼代造、江幡正悟、宮園浩平
- Organizer
  第18回日本がん分子標的治療学会学術集会
- Place of Presentation
  仙台市情報・産業プラザ（宮城県・仙台市）
- Year and Date
  2014-06-25
- Data Source
  KAKENHI-PLANNED-22112002
[Presentation] Regulation of EMT and related phenotypes by TGF-β in cancer cells (Symposium)2014
- Author(s)
  Koinuma D, Isogaya K, Sakurai T, Kawasaki N, Ehata S, Tsutsumi S, Saito A, Miyazawa K, Aburatani H, Miyazono K.
- Organizer
  第73回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜（神奈川県・横浜市）
- Year and Date
  2014-09-25
- Data Source
  KAKENHI-PLANNED-22112002
[Presentation] 肺腺癌細胞におけるFoxA1/2のSmad3標的遺伝子の制御2014
- Author(s)
  磯谷一暢、鯉沼代造、堤修一、油谷浩幸、宮園浩平
- Organizer
  第87回日本生化学会大会
- Place of Presentation
  国立京都国際会館（京都府・京都市）
- Year and Date
  2014-10-15
- Data Source
  KAKENHI-PLANNED-22112002
[Presentation] 肺線癌におけるTGF-β標的遺伝子RBM47の発現と作用機構の解析2014
- Author(s)
  櫻井翼、鯉沼代造、磯谷一暢、坂井慧、森川真大、森下保幸、江幡正悟、宮園浩平
- Organizer
  第87回日本生化学会大会
- Place of Presentation
  国立京都国際会館（京都府・京都市）
- Year and Date
  2014-10-15
- Data Source
  KAKENHI-PLANNED-22112002
[Presentation] Transforming growth factor-β-inducedlong non-coding RNA-Smad7 inhibits apoptosis of mouse breast cancer cells2014
- Author(s)
  荒瀬麻友、堀口華奈、江幡正悟、森川真大、堤修一、油谷浩幸、宮園浩平、鯉沼代造
- Organizer
  第14回東京大学生命科学ネットワークシンポジウム
- Place of Presentation
  東京
- Year and Date
  2014-04-26
- Data Source
  KAKENHI-PROJECT-24501311
[Presentation] Change in alternative splicing of FGFR during TGF-β-induced EMT. The 1st International Symposium by JSPS Core-to-Core Program2012
- Author(s)
  Horiguchi K, Koinuma D, Semba K, Miyazawa K, Miyazono K, Saitoh M.
- Organizer
  Cooperative International Framework in TGF-βFamily Signaling
- Place of Presentation
  東京大学小柴ホール(東京都)
- Year and Date
  2012-01-23
- Data Source
  KAKENHI-PROJECT-22790750
[Presentation] 次世代シーケンサーが明らかにするTGF-βファミリーシグナルの転写制御機構2012
- Author(s)
  鯉沼代造
- Organizer
  第27回つくば分子病理学セミナー
- Place of Presentation
  筑波大学(茨城県)(招待講演)
- Year and Date
  2012-02-08
- Data Source
  KAKENHI-PROJECT-22790750
[Presentation] Inhibitory mechanism of Thyroid transcription factor-1 on TGF-βsignaling in lung cancer cells. The 1st International Symposium by JSPS Core-to-Core Program2012
- Author(s)
  Isogaya K, Koinuma D, Tsutsumi S, Saito RA, Miyazawa K, Aburatani H, Miyazono K.
- Organizer
  Cooperative International Framework in TGF-βFamily Signaling
- Place of Presentation
  東京大学小柴ホール(東京都)
- Data Source
  KAKENHI-PROJECT-22790750
[Presentation] ChIP-seq reveals cell-type specific binding patterns of BMP-specific Smads and a novel binding motif2011
- Author(s)
  Morikawa M, Koinuma D, Tsutsumi S, Vasilaki E, Kanki Y, Heldin CH, Aburatani H, Miyazono K.
- Organizer
  FASEB Summer Research Conferences on the TGF-βSuperfamily
- Place of Presentation
  Lucca, Italy
- Data Source
  KAKENHI-PROJECT-22790750
[Presentation] Mechanism of Smad Signaling Modification by TTF1 in lung Cancer Cells2011
- Author(s)
  Isogaya K, Koinuma D, Tsutsumi S, Saito RA, Aburatani H, Miyazono K
- Organizer
  UCSF, 36th Annual Tetrad Research Conference
- Place of Presentation
  Lake Tahoe, U. S. A.
- Data Source
  KAKENHI-PROJECT-22790750
[Presentation] Characterization of Smad2 and Smad3 binding sites by genome-wide ChIP-chip/ChIP-sequencing analysis2010
- Author(s)
  鯉沼代造
- Organizer
  藤原セミナー
- Place of Presentation
  グランドホテルニュー王子(北海道苫小牧市)
- Year and Date
  2010-07-16
- Data Source
  KAKENHI-PROJECT-22790750
[Presentation] "Cistrome" of the TGF-β-Smad signaling pathway2010
- Author(s)
  鯉沼代造
- Organizer
  第33回日本分子生物学会年会・第83回日本生化学会大会合同大会
- Place of Presentation
  ポートピアホテル(兵庫県神戸市)
- Year and Date
  2010-12-10
- Data Source
  KAKENHI-PROJECT-22790750
[Presentation] Characterization of Smad binding sites by ChIP-chip2009
- Author(s)
  Koinuma, D.
- Organizer
  TGF-β meeting in Uppsala
- Place of Presentation
  University of Uppsala, Uppsala, Sweden
- Data Source
  KAKENHI-PROJECT-17016011
[Presentation] RB1CC1 is a co-factor of E3 ubiquitin ligase Arkadia in enhancement of TGF-β signaling.2008
- Author(s)
  Daizo Koinuma
- Organizer
  KEYSTONE SYMPOSIA: TGF-β Family in Homeostasis and Disease
- Place of Presentation
  米国
- Year and Date
  2008-02-05
- Data Source
  KAKENHI-PROJECT-18790555
[Presentation] 癌抑制候補遺伝子RB1CC1はArkadiaと協調しSmad7の分解を通してTGF-βスーパーファミリーシグナルを増強する.2007
- Author(s)
  鯉沼代造
- Organizer
  第30回日本分子生物学会年会・第80回日本生化学会大会合同大会
- Place of Presentation
  横浜
- Year and Date
  2007-12-14
- Data Source
  KAKENHI-PROJECT-18790555
[Presentation] RB1CC1 down-regulates Smad7 in cooperation with Arkadia and Smurf1 to enhance TGF-β signaling.2007
- Author(s)
  鯉沼代造
- Organizer
  第66回日本癌学会学術総会
- Place of Presentation
  横浜
- Year and Date
  2007-10-04
- Data Source
  KAKENHI-PROJECT-18790555
[Presentation] RB1CC1 down-regulates Smad7 in cooperation with Arkadia and Smurf1 to enhance TGF-β signaling.2007
- Author(s)
  鯉沼代造
- Organizer
  第47回日本呼吸器学会学術講演会
- Place of Presentation
  東京
- Year and Date
  2007-05-12
- Data Source
  KAKENHI-PROJECT-18790555
[Presentation] Identification of Smad regulatory factors through integrated analysis of ChIP-seq data
- Author(s)
  Koinuma D.
- Organizer
  Joint International Symposium on TGF-β Family and Cancer : Signal Network in Tumor Microenvironment
- Place of Presentation
  つくば
- Year and Date
  2015-01-12 – 2015-01-13
- Invited
- Data Source
  KAKENHI-PROJECT-24501311
[Presentation] Regulation of EMT and related phenotypes by TGF-β in cancer cells
- Author(s)
  Koinuma D, Isogaya K, Sakurai T, Kawasaki N, Ehata S, Tsutsumi S, Saito A, Miyazawa K, Aburatani H, Miyazono K.
- Organizer
  第73回日本癌学会学術総会
- Place of Presentation
  横浜
- Year and Date
  2014-09-25 – 2014-09-27
- Invited
- Data Source
  KAKENHI-PROJECT-24501311
[Presentation] E3リガーゼArkadiaによるスプライシング制御因子ESRP2の機能制御
- Author(s)
  水谷アンナ、鯉沼代造、宮園浩平
- Organizer
  平成26年度がん若手研究者ワークショップ
- Place of Presentation
  茅野
- Year and Date
  2014-09-03 – 2014-09-06
- Data Source
  KAKENHI-PROJECT-24501311
[Presentation] Arkadiaによるスプライシング制御因子ESRP2の機能制御
- Author(s)
  水谷アンナ、鯉沼代造、宮園浩平
- Organizer
  第87回日本生化学会大会
- Place of Presentation
  京都
- Year and Date
  2014-10-15 – 2014-10-18
- Data Source
  KAKENHI-PROJECT-24501311
[Presentation] FAIRE-seq analysis of TGF-β-induced EMT in mouse mammary gland epithelial cells
- Author(s)
  Arase M, Koinuma D, Isogaya K, Mizutani A, Tsutsumi S, Aburatani H, Miyazono K.
- Organizer
  Joint International Symposium on TGF-β Family and Cancer : Signal Network in Tumor Microenvironment
- Place of Presentation
  つくば
- Year and Date
  2015-01-12 – 2015-01-13
- Data Source
  KAKENHI-PROJECT-24501311
[Presentation] TGF-β誘導性long non-coding RNA-Smad7はマウス乳がん細胞のアポトーシスを抑制する
- Author(s)
  荒瀬麻友、堀口華奈、江幡正悟、森川真大、堤修一、油谷浩幸、宮園浩平、鯉沼代造
- Organizer
  第87回日本生化学会大会
- Place of Presentation
  京都
- Year and Date
  2014-10-15 – 2014-10-18
- Data Source
  KAKENHI-PROJECT-24501311
[Presentation] TGF-β誘導性long non-coding RNA-Smad7はマウス乳がん細胞のアポトーシスを抑制する
- Author(s)
  荒瀬麻友、江幡正悟、堤修一、油谷浩幸、宮園浩平、鯉沼代造
- Organizer
  第73回日本癌学会学術総会
- Place of Presentation
  横浜
- Year and Date
  2014-09-25 – 2014-09-27
- Data Source
  KAKENHI-PROJECT-24501311

1. MIYAZONO Kohei (90209908)

# of Collaborated Projects: 4 results

# of Collaborated Products: 25 results
2. EHATA Shogo (90506726)

# of Collaborated Projects: 3 results

# of Collaborated Products: 17 results
3. WATABE Tetsuro (00334235)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. MIYAZAWA Keiji (40209896)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
5. IMAMURA Takeshi (70264421)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
6. MAEDA Shingo (60353463)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. SAITOH Masao (90345041)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
8. KANO Mitsunobu (80447383)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. TABATA Yasuhiko (50211371)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. JO Jun-ichiro (60511243)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 森川真大 (80775833)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
12. 牛久哲男 (60376415)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. MUKASA Akitake

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 丸山一男

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. 丸山淳子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. 堤修一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
17. 油谷浩幸

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
18. 武井華奈

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
19. 古室暁義

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Koinuma Daizo 鯉沼 代造

KOINUMA Daizo 鯉沼 代造

Research Projects

Research Products

Co-Researchers

Molecular characterization of gastric carcinoma with a primitive phenotype

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胃がん・大腸がんにおいて変異SMAD4がもたらすエピゲノム制御異常と病態への関与Principal Investigator

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Role of a cell type-specific mechanism of TGF-beta signaling activation in lung fibrosisPrincipal Investigator

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Molecular mechanisms of cell differentiation and diversity by TGF-beta family members

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Changes in the binding regions of Smads downstream of TGF-beta signaling in diffuse type gastric cancersPrincipal Investigator

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Cistromic analysis of EMT regulators in breast cancer cellsPrincipal Investigator

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Roles of BMP signaling in maintenance of cell stemness

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ChIP-seq analysis of transcriptional regulation by BMP in relation to pulmonary hypertensionPrincipal Investigator

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Effects of TGF-beta family on cancer microenvironment and strategies for cancer therapy

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Role of lung cancer cells to fibrosis and regulation of TGF-beta signaling by EGFPrincipal Investigator

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呼吸器悪性腫瘍におけるTGF-βシグナル調節性E3ユビキチンリガーゼの役割Principal Investigator

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Establishment of New Strategies for Treatment of Cancer Using TGF-beta Signaling

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[Journal Article] Genome-wide analysis of DNA methylation identifies the apoptosis-related gene UQCRH as a tumor suppressor in renal cancer2022

Author(s)

Journal Title

Koinuma Daizo 鯉沼代造

KOINUMA Daizo 鯉沼代造