Takahashi Masahiko 高橋雅彦

… Alternative Names

TAKAHASHI Masahiko 高橋雅彦

高橋雅彦タカハシマサヒコ

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Researcher Number	80377192
Other IDs
Affiliation (Current)	2025: 新潟大学, 医歯学系, 准教授
Affiliation (based on the past Project Information) *help	2025: 新潟大学, 医歯学系, 准教授 2016 – 2023: 新潟大学, 医歯学系, 准教授 2014 – 2015: 新潟大学, 医歯学系, 講師 2011 – 2012: 新潟大学, 医歯学系, 助教 2005 – 2006: 新潟大学, 医歯学系, 助手
Review Section/Research Field	Principal Investigator Hematology / Virology / Basic Section 51030:Pathophysiologic neuroscience-related Except Principal Investigator Basic Section 50020:Tumor diagnostics and therapeutics-related / Experimental pathology
Keywords	Principal Investigator HTLV-1 / USP10 / ATL / ストレス顆粒 / Tax / パーキンソン病 / 成人T細胞白血病 / G3BP1 / ROS / 活性酸素種 … More / Tax1 / hBrm / 潜伏 / クロマチンリモデリング … More Except Principal Investigator 分子標的薬 / CD38 / ダラツムマブ / 輸血検査 / 多発性骨髄腫 / 分子標的試薬 / 抗CD38 抗体 / シグナル伝達 / 免疫学 / 炎症性腸疾患 / サイトカイン / 炎症 / NF-κB / IL-1 / TNFα / IL-1β / IL-6 / LPS / 炎症性サイトカイン / USP10 / マクロファージ Less

RNA結合活性が低下したTDP-43の凝集体形成機構の解明Principal Investigator
- Principal Investigator
  
  高橋雅彦
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 51030:Pathophysiologic neuroscience-related
- Research Institution
  Niigata University
多発性骨髄腫患者にて分子標的薬ダラツムマブによる輸血検査偽陽性の新規回避法の確立
- Principal Investigator
  
  川村宏樹
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Niigata University of Health and Welfare
USP10 in LPS-stimulated macrophages acts on Regnase-1 to suppress inflammatory cytokines.
- Principal Investigator
  
  KAWAMURA Hiroki
- Project Period (FY)
  2017 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Experimental pathology
- Research Institution
  Niigata University of Health and Welfare
Elucidation of a novel molecular mechanism that suppresses sensitivity to proteasome inhibitorsPrincipal Investigator
- Principal Investigator
  
  Takahashi Masahiko
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Niigata University
Elucidation of pathogenic mechanism of adult T-cell leukemia induced by abnormal ROS regulationPrincipal Investigator
- Principal Investigator
  
  Takahashi Masahiko
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Niigata University
The pathogenic mechanism of HTLV-1 leukemogenesis via novel binding protein of Tax1Principal Investigator
- Principal Investigator
  
  TAKAHASHI Masahiko
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Virology
- Research Institution
  Niigata University
HTLV-1遺伝子発現のエピジェネティックな抑制機構Principal Investigator
- Principal Investigator
  
  高橋雅彦
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Virology
- Research Institution
  Niigata University

All 2019 2018 2016 2015 2014 2013 2012 2011 2006 Other

All Journal Article Presentation

[Journal Article] USP10はアグリソームの形成を誘導し、ユビキチン化蛋白質オリゴマーの細胞毒性を抑制する2019
- Author(s)
  高橋雅彦、Piatnitskaia Svetlana, Anisimov Sergei, 藤井雅寛
- Journal Title
  
  新潟医学会雑誌
  
  Volume: 133 Pages: 91-96
- NAID
  120006840411
- Data Source
  KAKENHI-PROJECT-17K09918
[Journal Article] USP10 is a critical factor for Tau-positive stress granule formation in neuronal cells2019
- Author(s)
  Piatnitskaia S, Takahashi M, Kitaura H, Katsuragi Y, Kakihana T, Zhang L, Kakita A, Iwakura Y, Nawa H, Miura T, Ikeuchi T, Hara T, Fujii M
- Journal Title
  
  Scientific Reports
  
  Volume: 9 Issue: 1 Pages: 10591-10591
- DOI
  10.1038/s41598-019-47033-7
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07698, KAKENHI-PROJECT-19K17822, KAKENHI-PROJECT-19H03432, KAKENHI-PROJECT-19H03542, KAKENHI-PROJECT-16K09822, KAKENHI-PROJECT-17K07380, KAKENHI-PROJECT-17K09918
[Journal Article] G3BP1 inhibits ubiquitinated protein aggregations induced by p62 and USP102019
- Author(s)
  Anisimov S, Takahashi M, Kakihana T, Katsuragi Y, Kitaura H, Zhang L, Kakita A, Fujii M.
- Journal Title
  
  Sci Rep
  
  Volume: 9(1) Issue: 1 Pages: 12896-12896
- DOI
  10.1038/s41598-019-46237-1
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K17822, KAKENHI-PROJECT-19H03432, KAKENHI-PROJECT-19H03542, KAKENHI-PROJECT-16K09822, KAKENHI-PROJECT-17K07380, KAKENHI-PROJECT-17K09918
[Journal Article] USP10 Is a Driver of Ubiquitinated Protein Aggregation and Aggresome Formation to Inhibit Apoptosis.2018
- Author(s)
  Takahashi M, Kitaura H, Kakita A, Kakihana T, Katsuragi Y, Nameta M, Zhang L, Iwakura Y, Nawa H, Higuchi M, Komatsu M, Fujii M.
- Journal Title
  
  iScience
  
  Volume: 30 Pages: 433-450
- DOI
  10.1016/j.isci.2018.11.006
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K09822, KAKENHI-PROJECT-17K07380, KAKENHI-PROJECT-17K09918, KAKENHI-PROJECT-16K15502, KAKENHI-PROJECT-16H06276
[Journal Article] MAGI-1 expression is decreased in several types of human T-cell leukemia cell lines, including adult T-cell leukemia.2018
- Author(s)
  Kozakai T, Takahashi M, Higuchi M, Hara T, Saito K, Tanaka Y, Masuko M, Takizawa J, Sone H, Fujii M
- Journal Title
  
  International Journal of Hematology
  
  Volume: 107(3) Issue: 3 Pages: 337-344
- DOI
  10.1007/s12185-017-2359-1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K09868, KAKENHI-PROJECT-17K09918, KAKENHI-PROJECT-16K15502, KAKENHI-PROJECT-17K14989, KAKENHI-PROJECT-15H04704, KAKENHI-PROJECT-15K09469, KAKENHI-PROJECT-16K09822
[Journal Article] USP10 Is an Essential Deubiquitinase for Hematopoiesis and Inhibits Apoptosis of Long-Term Hematopoietic Stem Cells.2016
- Author(s)
  Higuchi M, Kawamura H, Matsuki H, Hara T, Takahashi M, Saito S, Saito K, Jiang S, Naito M, Kiyonari H, Fujii M.
- Journal Title
  
  Stem Cell Reports
  
  Volume: ７ Issue: 6 Pages: 1116-1129
- DOI
  10.1016/j.stemcr.2016.11.003
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15H04704, KAKENHI-PROJECT-26461417, KAKENHI-PROJECT-15K21003, KAKENHI-PROJECT-15K09469, KAKENHI-PROJECT-16K15502
[Journal Article] Human T-cell leukemia virus type 1 (HTLV-1) Tax1 oncoprotein but not HTLV-2 Tax2 induces the expression of OX40 ligand by interacting with p52/p100 and RelB.2016
- Author(s)
  Motai Y, Takahashi M, Takachi T, Higuchi M, Hara T, Mizuguchi M, Aoyagi Y, Terai S, Tanaka Y, Fujii M.
- Journal Title
  
  Virus Genes.
  
  Volume: 52 Issue: 1 Pages: 4-13
- DOI
  10.1007/s11262-015-1277-7
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26461417, KAKENHI-PROJECT-15K21003, KAKENHI-PROJECT-26670222, KAKENHI-PROJECT-15H04704, KAKENHI-PROJECT-16K15502
[Journal Article] RASAL3, a novel hematopoietic RasGAP protein, regulates the number and functions of NKT cells.2015
- Author(s)
  Saito S, Kawamura T, Higuchi M, Kobayashi T, Yoshita-Takahashi M, Yamazaki M, Abe M, Sakimura K, Kanda Y, Kawamura H, Jiang S, Naito M, Yoshizaki T, Takahashi M, Fujii M.
- Journal Title
  
  Eur J Immunol.
  
  Volume: in press Issue: 5 Pages: 1512-1523
- DOI
  10.1002/eji.201444977
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26461417, KAKENHI-PROJECT-26670222, KAKENHI-PROJECT-26460990, KAKENHI-PROJECT-221S0003, KAKENHI-PROJECT-15H04704
[Journal Article] Human T-cell leukemia virus type 1 Tax oncoprotein represses the expression of the BCL11B tumor suppressor in T-cells2015
- Author(s)
  Takachi T, Takahashi M, Takahashi-Yoshita M, Higuchi M, Obata M, Mishima Y, Okuda S, Tanaka Y, Matsuoka M, Saitoh A, Green PL, Fujii M.
- Journal Title
  
  Cance Science
  
  Volume: 106(4) Issue: 4 Pages: 461-465
- DOI
  10.1111/cas.12618
- NAID
  120006844098
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26670222, KAKENHI-PROJECT-221S0001, KAKENHI-PROJECT-26461417, KAKENHI-PROJECT-15H04704, KAKENHI-PROJECT-25340027, KAKENHI-PROJECT-26242088
[Journal Article] Downregulation of proapoptotic Bim augments IL-2-independent T-cell transformation by human T-cell leukemia virus type-1 Tax.2014
- Author(s)
  Higuchi M, Takahashi M, Tanaka Y, Fujii M.
- Journal Title
  
  Cancer Med.
  
  Volume: 3 Issue: 6 Pages: 1605-1614
- DOI
  10.1002/cam4.329
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26461417, KAKENHI-PROJECT-26670222, KAKENHI-PROJECT-221S0001
[Journal Article] Both G3BP1 and G3BP2 contribute to stress granule formation.2013
- Author(s)
  Hideaki Matsuki
- Journal Title
  
  Genes to Cells
  
  Volume: 18 Issue: 2 Pages: 135-146
- DOI
  10.1111/gtc.12023
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590537, KAKENHI-PROJECT-23790498
[Journal Article] Human T cell leukemia virus type 2 (HTLV-2) Tax2 has a dominant activity over HTLV-1 Tax1 to immortalize human CD4+ T cells.2013
- Author(s)
  Michitaka Imai
- Journal Title
  
  Virus Genes
  
  Volume: 46 Issue: 1 Pages: 39-46
- DOI
  10.1007/s11262-012-0831-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590537, KAKENHI-PROJECT-23591376, KAKENHI-PROJECT-23659395, KAKENHI-PROJECT-23790436, KAKENHI-PROJECT-23790498, KAKENHI-PROJECT-221S0001
[Journal Article] Stress granules inhibit apoptosis by reducing reactive oxygen species production.2013
- Author(s)
  Masahiko Takahashi
- Journal Title
  
  Molecular and Cellular Biology
  
  Volume: 33 Issue: 4 Pages: 815-829
- DOI
  10.1128/mcb.00763-12
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590537, KAKENHI-PROJECT-23591376, KAKENHI-PROJECT-23790498
[Journal Article] Activation of mTOR by human T-cell leukemia virus type 1 Tax is important for the transformation of mouse T cells to interleukin-2-independent growth2011
- Author(s)
  Manami Yoshita
- Journal Title
  
  Cancer Science
  
  Volume: 103巻 Issue: 2 Pages: 369-374
- DOI
  10.1111/j.1349-7006.2011.02123.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590537, KAKENHI-PROJECT-23790498
[Journal Article] Inactivation of tumor suppressor Dlg1 augments transformation of a T-cell line induced by human T-cell leukemia virus type 1 Tax protein.2006
- Author(s)
  Ishioka, K., Higuchi, M., Takahashi, M., Yoshida, S., Oie, M., Tanaka, Y., Takahashi, S., Xie, L., Green, P.L., Fujii, M.
- Journal Title
  
  Retrovirology 3
  
  Pages: 71-71
- Data Source
  KAKENHI-PROJECT-17790303
[Journal Article] Human T-cell leukemia virus type 2 Tax protein induces interleukin 2-independent growth in a T-cell line.2006
- Author(s)
  Kondo, R., Higuchi, M., Takahashi, M., Oie, M., Tanaka, Y., Gejyo, F., Fujii, M.
- Journal Title
  
  Retrovirology 3
  
  Pages: 88-88
- Data Source
  KAKENHI-PROJECT-17790303
[Presentation] USP10 IS A CRITICAL FACTOR IN α-SYNUCLEIN AGGREGATION, AGGRESOME AND LEWY BODY FORMATIONS BUT NOT GCI2019
- Author(s)
  Masahiko Takahashi, Hiroki Kitaura, Akiyoshi Kakita, Taichi Kakihana, Yoshinori Katsuragi, Masaaki Nameta, Yuriko Iwakura, Hiroyuki Nawa, Masaya Higuchi, Masaaki Komatsu, Masahiro Fujii
- Organizer
  24th World Congress of Neurology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09918
[Presentation] USP10は亜ヒ酸によるHTLV-1感染細胞のアポトーシス感受性に関与する2012
- Author(s)
  高橋雅彦
- Organizer
  第5回HTLV研究会およびシンポジウム
- Place of Presentation
  東京
- Year and Date
  2012-08-25
- Data Source
  KAKENHI-PROJECT-23790498
[Presentation] Stress granules inhibit apoptosis by reducing ROS production, and this is nullified by HTLV-1 Tax12012
- Author(s)
  高橋雅彦
- Organizer
  第71回日本癌学会学術集会
- Place of Presentation
  札幌
- Year and Date
  2012-09-19
- Data Source
  KAKENHI-PROJECT-23790498
[Presentation] ストレス顆粒はROS産生を抑制することによりアポトーシスを阻害するが、これをHTLV-1のTax1は解除する
- Author(s)
  高橋　雅彦
- Organizer
  日本癌学会
- Place of Presentation
  ロイトン札幌（北海道）
- Data Source
  KAKENHI-PROJECT-23790498

1. KAWAMURA Hiroki (20333495)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
2. 樋口雅也 (50334678)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
3. Hara Toshifumi

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
4. Saito Kousuke

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. 藤井雅寛

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
6. 増子正義

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 垣花太一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Takahashi Masahiko 高橋 雅彦

TAKAHASHI Masahiko 高橋 雅彦

高橋 雅彦 タカハシ マサヒコ

Research Projects

Research Products

Co-Researchers

RNA結合活性が低下したTDP-43の凝集体形成機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

多発性骨髄腫患者にて分子標的薬ダラツムマブによる輸血検査偽陽性の新規回避法の確立

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

USP10 in LPS-stimulated macrophages acts on Regnase-1 to suppress inflammatory cytokines.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Elucidation of a novel molecular mechanism that suppresses sensitivity to proteasome inhibitorsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Elucidation of pathogenic mechanism of adult T-cell leukemia induced by abnormal ROS regulationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The pathogenic mechanism of HTLV-1 leukemogenesis via novel binding protein of Tax1Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

HTLV-1遺伝子発現のエピジェネティックな抑制機構Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] USP10はアグリソームの形成を誘導し、ユビキチン化蛋白質オリゴマーの細胞毒性を抑制する2019

Author(s)

Journal Title

NAID

Data Source

[Journal Article] USP10 is a critical factor for Tau-positive stress granule formation in neuronal cells2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] G3BP1 inhibits ubiquitinated protein aggregations induced by p62 and USP102019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] USP10 Is a Driver of Ubiquitinated Protein Aggregation and Aggresome Formation to Inhibit Apoptosis.2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] MAGI-1 expression is decreased in several types of human T-cell leukemia cell lines, including adult T-cell leukemia.2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] USP10 Is an Essential Deubiquitinase for Hematopoiesis and Inhibits Apoptosis of Long-Term Hematopoietic Stem Cells.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Human T-cell leukemia virus type 1 (HTLV-1) Tax1 oncoprotein but not HTLV-2 Tax2 induces the expression of OX40 ligand by interacting with p52/p100 and RelB.2016

Author(s)

Takahashi Masahiko 高橋雅彦

TAKAHASHI Masahiko 高橋雅彦

高橋雅彦タカハシマサヒコ