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LIN Youwei  林 幼偉

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Lin Youwei  林 幼偉

林 幼偉  リン ヨウイ

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Researcher Number 80392439
Other IDs
Affiliation (Current) 2025: 国立研究開発法人国立精神・神経医療研究センター, 神経研究所 免疫研究部, 併任研究員
Affiliation (based on the past Project Information) *help 2015 – 2022: 国立研究開発法人国立精神・神経医療研究センター, 神経研究所 免疫研究部, 併任研究員
2013 – 2014: 独立行政法人国立精神・神経医療研究センター, 神経研究所免疫研究部, 併任研究員
2010: 独立行政法人国立精神・神経医療研究センター, 神経研究所 免疫研究部, 併任研究員
2009 – 2010: National Center of Neurology and Psychiatry, 神経研究所免疫研究部, 併任研究員
2007: National Center of Neurology and Psychiatry, 神経研究所 免疫研究部, 併任研究員
2006: 国立精神・神経センター, 神経研究所免疫研究部, 併任研究員
Review Section/Research Field
Principal Investigator
Neurology
Except Principal Investigator
Medium-sized Section 52:General internal medicine and related fields
Keywords
Principal Investigator
実験的自己免疫性脳脊髄炎 / 寛解維持 / 制御性T細胞 / 自己免疫ワクチン / 多発性硬化症 / 脳炎惹起性ペプチド / 抗原特異性 / ペプチド優位性 / 制御性T細胞 / 制御性細胞 … More / 脳・神経疾患 / 免疫学 / 慢性化制御 / 組織特異的自己免疫ワクチン / 神経免疫疾患 / 寛解不全と慢性進行 / 組織修復 / 安定型制御性T細胞 / 寛解不全と進行 / 組織修復能 / MHC・ペプチド結合度 / 抗原特異的制御性T細胞 / 慢性進行抑制 / 再発寛解維持 / ペプチドヒエラルキー / 制御性T細胞細胞 / ペプチドワクチン / 再発と寛解 / 優位エピトープ / 神経病態免疫学 … More
Except Principal Investigator
Th17細胞 / 甲状腺ホルモン / Eomes陽性Th細胞 / EAE / 神経・内分泌・免疫制御 / 神経・免疫・内分泌連関 / 中枢神経慢性炎症 / 神経・免疫・内分泌相関 / 内分泌性制御因子 / Eomes+ Th細胞 / プロラクチン / 環境因子 / 内分泌性免疫制御因子 / 免疫性神経疾患 Less
  • Research Projects

    (5 results)
  • Research Products

    (44 results)
  • Co-Researchers

    (8 People)
  •  Cross-talk between endocrine and environmental factors in neuroimmune disorders

    • Principal Investigator
      Yamamura Takashi
    • Project Period (FY)
      2018 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Review Section
      Medium-sized Section 52:General internal medicine and related fields
    • Research Institution
      National Center of Neurology and Psychiatry
  •  Inverse vaccination for autoimmune diseases and therapy for their chronic progression by multi-functional antigen-specific regulatory cell governing multiple sclerosisPrincipal Investigator

    • Principal Investigator
      Lin Youwei
    • Project Period (FY)
      2016 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Neurology
    • Research Institution
      National Center of Neurology and Psychiatry
  •  induction of multi-functional regulatory T cell involved in maintenance of multiple sclerosis : application for vaccination of autoimmune diseasesPrincipal Investigator

    • Principal Investigator
      Lin Youwei
    • Project Period (FY)
      2013 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Neurology
    • Research Institution
      National Center of Neurology and Psychiatry
  •  Regulation in maintenance of remission involving the prognosis of a model of Multiple SclerosisPrincipal Investigator

    • Principal Investigator
      LIN Youwei
    • Project Period (FY)
      2009 – 2010
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Neurology
    • Research Institution
      National Center of Neurology and Psychiatry
  •  実験的自己免疫性脳脊髄炎の再発・寛解に関わる制御性T細胞を誘導する因子の解明Principal Investigator

    • Principal Investigator
      林 幼偉
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Neurology
    • Research Institution
      National Center of Neurology and Psychiatry

All 2023 2021 2019 2018 2017 2016 2015 2013 2010 2009 2008 2007 2006 Other

All Journal Article Presentation Book

  • [Book] 臨床免疫・アレルギー科2016

    • Author(s)
      林 幼偉、山村 隆
    • Total Pages
      9
    • Publisher
      科学評論社
    • Data Source
      KAKENHI-PROJECT-25461301
  • [Book] 日本臨床免疫学会会誌2015

    • Author(s)
      林 幼偉
    • Total Pages
      8
    • Publisher
      日本臨床免疫学会
    • Data Source
      KAKENHI-PROJECT-25461301
  • [Journal Article] First-in-human clinical trial of the NKT cell-stimulatory glycolipid OCH in multiple sclerosis2023

    • Author(s)
      Sato Wakiro、Noto Daisuke、Araki Manabu、Okamoto Tomoko、Lin Youwei、Yamaguchi Hiromi、Kadowaki-Saga Ryoko、Kimura Atsuko、Kimura Yukio、Sato Noriko、Ishizuka Takami、Nakamura Harumasa、Miyake Sachiko、Yamamura Takashi
    • Journal Title

      Therapeutic Advances in Neurological Disorders

      Volume: 16

    • DOI

      10.1177/17562864231162153

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18H04045, KAKENHI-PROJECT-21H02964
  • [Journal Article] Ratio of lymphocyte to monocyte area under the curve as a novel predictive factor for severe infection in multiple sclerosis2023

    • Author(s)
      Takahashi Junichiro、Okamoto Tomoko、Lin Youwei、Saika Reiko、Katsumoto Atsuko、Sato Wakiro、Yamamura Takashi、Takahashi Yuji
    • Journal Title

      Frontiers in Immunology

      Volume: 14

    • DOI

      10.3389/fimmu.2023.1133444

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18H04045
  • [Journal Article] Involvement of cytotoxic Eomes-expressing CD4+ T cells in secondary progressive multiple sclerosis2021

    • Author(s)
      Raveney Ben J. E.、Sato Wakiro、Takewaki Daiki、Zhang Chenyang、Kanazawa Tomomi、Lin Youwei、Okamoto Tomoko、Araki Manabu、Kimura Yukio、Sato Noriko、Sano Terunori、Saito Yuko、Oki Shinji、Yamamura Takashi
    • Journal Title

      Proceedings of the National Academy of Sciences

      Volume: 118 Issue: 11 Pages: 2021818118-2021818118

    • DOI

      10.1073/pnas.2021818118

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K07775, KAKENHI-PROJECT-20K07895, KAKENHI-PROJECT-20K16294, KAKENHI-PROJECT-18H04045
  • [Journal Article] Th1-CD11c+ B cell axis associated with response to plasmapheresis in multiple sclerosis2021

    • Author(s)
      Kimura, K., Y. Lin, H. Yamaguchi, W. Sato, D. Takewaki, M. Minote, Y. Doi, T. Okamoto, R. Takahashi, T. Kondo, and T. Yamamura
    • Journal Title

      Ann Neurol

      Volume: 90 Issue: 4 Pages: 595-611

    • DOI

      10.1002/ana.26202

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18H04045
  • [Journal Article] Gut microbiota-dependent CCR9+CD4+ T cells are altered in secondary progressive multiple sclerosis2019

    • Author(s)
      Kadowaki, A., R. Saga, Y. Lin, W. Sato, and T. Yamamura
    • Journal Title

      Brain

      Volume: 142(4) Issue: 4 Pages: 916-931

    • DOI

      10.1093/brain/awz012

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18H04045
  • [Journal Article] 実験的自己免疫性脳脊髄炎(EAE)の寛解維持に関わる制御機構2008

    • Author(s)
      林幼偉
    • Journal Title

      Neuroimmunology(日本神経免疫学会機関誌) 16-2

      Pages: 183-189

    • Data Source
      KAKENHI-PROJECT-21790855
  • [Journal Article] 誘導型制御性T細胞の特徴2007

    • Author(s)
      林 幼偉、山村 隆
    • Journal Title

      臨床免疫・アレルギー科 48-5

      Pages: 483-490

    • Data Source
      KAKENHI-PROJECT-18790606
  • [Journal Article] 誘導型制御性T細胞の特徴2007

    • Author(s)
      林幼偉、山村隆
    • Journal Title

      臨床免疫アレルギー科 48-5

      Pages: 483-490

    • Data Source
      KAKENHI-PROJECT-21790855
  • [Journal Article] Induction of adaptive regulatory T cells during recovery of EAE sensitized with PLP136-150 in SJL/J mice : the presence of suppressor epitope within PLP2006

    • Author(s)
      Youwei Lin, Sachiko Miyake, Takashi Yamamura
    • Journal Title

      Journal of Neuroimmunology 178 supl

      Pages: 151-151

    • Data Source
      KAKENHI-PROJECT-18790606
  • [Presentation] Harnessing autoimmunity with superior dominant peptide as inverse vaccination via manipulating antigen-specific hybrid Tregs that restrict the disease-related antigens and promote tissue repair capacity2019

    • Author(s)
      Lin Y, Massilamany C, Reddy J, Yamamura T
    • Organizer
      13th World Immune Regulation Meeting, Davos, Switzerland
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18H04045
  • [Presentation] Inverse vaccination for multiple sclerosis in control of the disease activity--superior dominant peptide restricts the reactivity to disease-associated antigens and promotes tissue-repair capacity by sequentially induction of stabilized antigen-specific hybrid regulatory T cells2018

    • Author(s)
      Youwei Lin
    • Organizer
      第5回MSサマースクール
    • Data Source
      KAKENHI-PROJECT-16K09706
  • [Presentation] Increases in Eomes-expressing Th cells in secondary progressive multiple sclerosis reveal patients at risk of increased disability2018

    • Author(s)
      Ben JE Raveney, Wakiro Sato, Daiki Takewaki, Youwei Lin, Tomoko Okamoto, Manabu Araki, Shinji Oki and Takashi Yamamura
    • Organizer
      14th ISNI.Brisbane
    • Data Source
      KAKENHI-PROJECT-18H04045
  • [Presentation] ncreases in Eomes-expressing Th cells in secondary progressive multiple sclerosis reveal patients at risk of Increased disability2018

    • Author(s)
      Ben Raveney, Wakiro Sato, Daiki Takewaki, Youwei Lin, Tomoko Okamoto, Manabu Araki, Shinji Oki, Takashi Yamamura
    • Organizer
      FOCIS2018.San Francisco
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18H04045
  • [Presentation] Manipulating the stability of antigen-specific Treg by enhancing the functional avidity of the superior dominant peptide via its flanking residues harnesses autoimmunity with restricting the reactivity to disease-related antigens and promoting tissue repair capacity2018

    • Author(s)
      Youwei Lin,
    • Organizer
      第47回日本免疫学会学術集会
    • Data Source
      KAKENHI-PROJECT-16K09706
  • [Presentation] Harnessing autoimmunity with superior dominant peptide to enhance the binding stability manipulate antigen-specific Tregs that restrict the disease-related antigens and promote tissue repair capacity.2018

    • Author(s)
      Youwei Lin, Takashi Yamamura
    • Organizer
      14th ISNI.Brisbane
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18H04045
  • [Presentation] Harnessing autoimmunity with superior dominant peptide to enhance the binding stability manipulate antigen-specific Tregs that restrict the disease-related antigens and promote tissue repair capacity2018

    • Author(s)
      Youwei Lin
    • Organizer
      第14回国際神経免疫学会
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K09706
  • [Presentation] Manipulating the stability of antigen-specific Treg by enhancing the functional avidity of the superior dominant peptide via its flanking residues harnesses autoimmunity with restricting the reactivity to disease-related antigens and promoting tissue repair capacity2018

    • Author(s)
      Youwei Lin, Takashi Yamamura
    • Organizer
      第47回日本免疫学会学術集会.福岡
    • Data Source
      KAKENHI-PROJECT-18H04045
  • [Presentation] 自己免疫ワクチンによるMS治療:superior dominant peptideによる抗原特異的Treg の組織反応性と組織修復能2017

    • Author(s)
      林 幼偉
    • Organizer
      第29回日本神経免疫学会
    • Data Source
      KAKENHI-PROJECT-16K09706
  • [Presentation] SENSITIZATION OF SUPERIOR DOMINANT PEPTIDE MAY ERADICATE MULTIPLE SCLEROSIS THROUGHOUT BY SEQUENTIAL INDUCTION OF STABILIZED HYBRID REGULATORY T CELLS WITH DIVERSE ANTIGEN-SPECIFICITY AND TISSUE-REPAIR CAPACITY2017

    • Author(s)
      Youwei Lin
    • Organizer
      第23回世界神経学会
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K09706
  • [Presentation] Inverse vaccination by superior dominant peptide inhibit the reactivity to disease-associated antigens and promote tissue-repair capacity in stabilized antigen-specific regulatory T cells to control of relapsing and progression of animal model of multiple sclerosis2017

    • Author(s)
      Youwei Lin
    • Organizer
      第45回日本免疫学会
    • Data Source
      KAKENHI-PROJECT-16K09706
  • [Presentation] Antigen-specificity of superior dominant encephalitogenic peptide confers inductivity, stability, and hybrid signatures to CD69+CD103+ subset of Treg responsible for sustainable inhibition of CNS autoimmune diseases.2016

    • Author(s)
      Youwei Lin
    • Organizer
      第16回国際免疫学会
    • Place of Presentation
      メルボルン、メルボルン国際コンベンションエキシビションセンター
    • Year and Date
      2016-08-21
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K09706
  • [Presentation] Inverse vaccination with superior dominant peptide may harness autoimmune diseases via sequential induction of stabilized hybrid regulatory T cells with antigen specificity and tissue repair capacity2016

    • Author(s)
      Youwei Lin
    • Organizer
      第45回日本免疫学会
    • Place of Presentation
      京都、京都国際会館
    • Year and Date
      2016-12-05
    • Data Source
      KAKENHI-PROJECT-16K09706
  • [Presentation] Inverse vaccination with superior dominant peptide may eradicate multiple sclerosis via sequential induction of stabilized hybrid regulatory T cells with antigen specificity and tissue repair capacity2016

    • Author(s)
      Youwei Lin
    • Organizer
      第13回国際神経免疫学会
    • Place of Presentation
      エルサレム、国際コンベンションセンター
    • Year and Date
      2016-09-26
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K09706
  • [Presentation] Dominant peptide therapy may conquer MS by turning antigen-specificity and stability to hybrid Treg.2016

    • Author(s)
      Youwei Lin
    • Organizer
      第57回日本神経学会
    • Place of Presentation
      神戸、神戸国際会議場
    • Year and Date
      2016-05-18
    • Data Source
      KAKENHI-PROJECT-16K09706
  • [Presentation] Hybrid Treg possessed high antigen-specificity and stabilized in under antigen stimulation2015

    • Author(s)
      Youwei Lin, Sachiko Miyake, Takashi Yamamura
    • Organizer
      第44回日本免疫学会学術集会
    • Place of Presentation
      札幌、札幌コンベンションセンター:メインホール
    • Year and Date
      2015-11-18
    • Data Source
      KAKENHI-PROJECT-25461301
  • [Presentation] Inverse vaccination for multiple sclerosis model by superior dominant peptide2015

    • Author(s)
      Youwei Lin, Sachiko Miyake, Takashi Yamamura
    • Organizer
      第56回日本神経学会
    • Place of Presentation
      新潟、朱鷺メッセ:1階展示ホールB-1(第9会場)
    • Year and Date
      2015-05-20
    • Data Source
      KAKENHI-PROJECT-25461301
  • [Presentation] 実験的自己免疫性脳脊髄炎(EAE)の寛解維持を担う’armoured Treg’の誘導:dominant epitopeによるペプチドワクチンへの可能性2013

    • Author(s)
      林 幼偉
    • Organizer
      第41回日本臨床免疫学会
    • Place of Presentation
      ポスター会場(展示見本市会場):海峡メッセ下関(下関)
    • Data Source
      KAKENHI-PROJECT-25461301
  • [Presentation] Dominancy of encephalitogenic peptide itself directs sustainable regulation of a model of multiple sclerosis: possibility of autoimmune vaccination2013

    • Author(s)
      Youwei Lin
    • Organizer
      第42回日本免疫学会
    • Place of Presentation
      ポスター会場(国際展示場No7):幕張メッセ(千葉幕張)
    • Data Source
      KAKENHI-PROJECT-25461301
  • [Presentation] Dominancy of encephalitogenic peptide itself directs sustainable regulation of a model of multiple sclerosis, through induction of 'armoured' regulatory T cells2010

    • Author(s)
      林幼偉
    • Organizer
      第10回国際神経免疫学会
    • Place of Presentation
      バルセロナ(スペイン)Hotel Melia Congress Center in Sitges
    • Year and Date
      2010-10-26
    • Data Source
      KAKENHI-PROJECT-21790855
  • [Presentation] Dominancy of encephalitogenic peptide itself directs sustainable regulation of a model of multiple sclerosis, through induction of 'armoured' regulatory T cells.2010

    • Author(s)
      Youwei Lin, Sachiko Miyake, Takashi Yamamura.
    • Organizer
      第14回国際免疫学会
    • Place of Presentation
      神戸
    • Data Source
      KAKENHI-PROJECT-21790855
  • [Presentation] Dominancy of encephalitogenic peptide itself directs sustainable regulation of a model of multiple sclerosis, through induction of 'armoured' regulatory T cells.2010

    • Author(s)
      Youwei Lin, Sachiko Miyake, Takashi Yamamura.
    • Organizer
      第10回国際神経免疫学会
    • Place of Presentation
      バルセロナ
    • Year and Date
      2010-10-26
    • Data Source
      KAKENHI-PROJECT-21790855
  • [Presentation] Dominancy of encephalitogenic peptide itself directs sustainable regulation of a model of multiple sclerosis, through induction of 'armoured' regulatory T cells2010

    • Author(s)
      林幼偉
    • Organizer
      第14回国際免疫学会
    • Place of Presentation
      神戸(日本)神戸ポートピアホテル・神戸国際展示場
    • Data Source
      KAKENHI-PROJECT-21790855
  • [Presentation] EAEの寛解を維持する機能的制御性T細胞の誘導に相関する脳炎惹起性ペプチドの優位性2009

    • Author(s)
      林幼偉
    • Organizer
      第50回日本神経学会
    • Place of Presentation
      仙台国際センター
    • Year and Date
      2009-05-20
    • Data Source
      KAKENHI-PROJECT-21790855
  • [Presentation] EAEの寛解を維持する機能的制御性T細胞の誘導に相関する脳炎惹起性ペプチドの優位性2009

    • Author(s)
      林幼偉、三宅幸子、山村隆
    • Organizer
      第50回日本神経学会
    • Place of Presentation
      仙台
    • Year and Date
      2009-05-20
    • Data Source
      KAKENHI-PROJECT-21790855
  • [Presentation] EAE寛解期に誘導されるCD69^+CD103^+の制御性T細胞はEAE寛解維持・再誘導抑制を担うObstructing regulatory T cells as a strategy used by dangerous self-peptide2007

    • Author(s)
      林 幼偉
    • Organizer
      第37回日本免疫学会
    • Place of Presentation
      東京
    • Year and Date
      2007-11-22
    • Data Source
      KAKENHI-PROJECT-18790606
  • [Presentation] EAE寛解期に誘導されるCD69^+CD103^+の制御性T細胞はEAE寛解維持・再誘導抑制を担うObstructing regulatory T cells as a strategy used by dangerous self-peptide2007

    • Author(s)
      林 幼偉
    • Organizer
      第8回国際神経学会
    • Place of Presentation
      リオデジャネイロ
    • Data Source
      KAKENHI-PROJECT-18790606
  • [Presentation] EAE寛解期に誘導されるCD69^+CD103^+の制御性T細胞はEAE寛解維持・再誘導抑制を担うObstructing regulatory T cells as a strategy used by dangerous self-peptide2007

    • Author(s)
      林 幼偉
    • Organizer
      第19回日本神経免疫学会
    • Place of Presentation
      金沢
    • Year and Date
      2007-04-12
    • Data Source
      KAKENHI-PROJECT-18790606
  • [Presentation] EAE寛解期に誘導されるCD69^+CD103^+の制御性T細胞はEAE寛解維持・再誘導抑制を担うObstructing regulatory T cells as a strategy used by dangerous self-peptide2007

    • Author(s)
      林 幼偉
    • Organizer
      第48回日本神経学会
    • Place of Presentation
      名古屋
    • Year and Date
      2007-05-17
    • Data Source
      KAKENHI-PROJECT-18790606
  • [Presentation] EAE寛解期に誘導されるCD69^+CD103^+の制御性T細胞はEAE寛解維持・再誘導抑制を担うObstructing regulatory T cells as a strategy used by dangerous self-peptide2007

    • Author(s)
      林 幼偉
    • Organizer
      ECTRIMS2007
    • Place of Presentation
      プラハ
    • Year and Date
      2007-10-11
    • Data Source
      KAKENHI-PROJECT-18790606
  • [Presentation] ‘Superior’ dominant peptide itself shut down the reactivation of an animal model of multiple sclerosis through later activation of antigen-specific regulatory cells: application for inverse vaccine.

    • Author(s)
      Youwei Lin
    • Organizer
      第12回国際神経免疫学会
    • Place of Presentation
      ドイツ・マインツ、Rheingoldhalle: Rheinfoyer
    • Year and Date
      2014-11-09 – 2014-11-13
    • Data Source
      KAKENHI-PROJECT-25461301
  • [Presentation] Inverse vaccination for autoimmune diseases by sensitization of superior dominant peptide through efficient induction of functionally stable regulatory T cells possessing high antigen-specificity

    • Author(s)
      Youwei Lin
    • Organizer
      第43回日本免疫学会
    • Place of Presentation
      京都、京都国際会議場:ルームE
    • Year and Date
      2014-12-10 – 2014-12-12
    • Data Source
      KAKENHI-PROJECT-25461301
  • [Presentation] Inverse vaccination for multiple sclerosis model by superior dominant peptide

    • Author(s)
      Youwei Lin
    • Organizer
      第56回日本神経学会
    • Place of Presentation
      新潟、朱鷺メッセ:展示ホールB-1
    • Year and Date
      2015-05-20 – 2015-05-23
    • Data Source
      KAKENHI-PROJECT-25461301
  • 1.  Yamamura Takashi (90231670)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 9 results
  • 2.  大木 伸司 (50260328)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 3.  北條 浩彦 (60238722)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 4.  佐藤 和貴郎 (90469990)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 6 results
  • 5.  大島 登志男 (20311334)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 6.  服部 正平 (70175537)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  土居 芳充 (20597174)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 8.  Raveney Benjamin
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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