Shinohara Fumiaki 篠原文明

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SHINOHARA Fumiaki 篠原文明

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Researcher Number	80400258
Other IDs
Affiliation (Current)	2025: 東北医科薬科大学, 東北医科薬科大学病院, 歯科口腔外科医長
Affiliation (based on the past Project Information) *help	2014: 東北大学, 歯学研究科, 非常勤講師 2013 – 2014: 東北大学, 歯学研究科(研究院), 非常勤講師 2013: 東北大学, 歯学研究科(研究院), 大学院非常勤講師 2011 – 2012: 東北大学, 大学病院, 助教 2007 – 2010: Tohoku University, 病院, 助教
Review Section/Research Field	Principal Investigator Surgical dentistry Except Principal Investigator Surgical dentistry
Keywords	Principal Investigator 癌 / エピジェネティクス / 口腔癌 / 血管新生 / 口腔外科学一般(含病態検査学) / EGFR / 抗癌剤 / 上皮成長因子 / インターフェロンガンマ / 分子標的薬 / 上皮増殖因子 / リンパ節転移 / VEGF … More Except Principal Investigator … More ADAM / 腫瘍細胞 / インターフェロンガンマ / NK細胞 / ADAM17 / インターフェロンγ / TACE / ADAM１７ / 破骨細胞 / サイトカイン / 腫瘍免疫 / インターフェロン Less

Elucidation of pro-metastatic property of interferon degradation
- Principal Investigator
  
  KANZAKI Hiroyuki
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Surgical dentistry
- Research Institution
  Tsurumi University
  Tohoku University
Analysis of sensitivity of oral cancer to Cetuximab and gene modification of KRAS, BRAF and PIK3CA in OSCC.Principal Investigator
- Principal Investigator
  
  SHINOHARA FUMIAKI
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Surgical dentistry
- Research Institution
  Tohoku University
Epigenetic regulation of VEGF-C/-D in cervical lymph node metastasis.Principal Investigator
- Principal Investigator
  
  SHINOHARA Fumiaki
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Surgical dentistry
- Research Institution
  Tohoku University
Suppression of angiogenesis and metastasis on OSCC using epigenetical agents.Principal Investigator
- Principal Investigator
  
  SHINOHARA Fumiaki
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Surgical dentistry
- Research Institution
  Tohoku University

All 2015 2014 2013 2012 2011 2010 2009 2008 2007 Other

All Journal Article Presentation

[Journal Article] Nrf2 Activation Attenuates Both Orthodontic Tooth2015
- Author(s)
  Kanzaki, H., Shinohara, F., Kajiya, M., Fukaya, S., Miyamoto, Y., & Nakamura, Y.
- Journal Title
  
  Journal of Dental Research.
  
  Volume: in press
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25670841
[Journal Article] Nuclear nrf2 induction by protein transduction attenuates osteoclastogenesis2014
- Author(s)
  Kanzaki, H. Shinohara, F. Kajiya, M. Fukaya, S. Miyamoto, Y. Nakamura, Y.
- Journal Title
  
  Free Radic Biol Med
  
  Volume: 77 Pages: 239-248
- DOI
  10.1016/j.freeradbiomed.2014.09.006
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25670841
[Journal Article] The Keap1/Nrf2 axis plays a role in osteoclast differentiation by regulating intracellular ROS signaling.2013
- Author(s)
  H Kanzaki, F Shinohara, M Kajiya, T kodama
- Journal Title
  
  J Bio Chem
  
  Volume: 32 Issue: 32 Pages: 23009-23020
- DOI
  10.1074/jbc.m113.478545
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592954, KAKENHI-PROJECT-23689081
[Journal Article] Rapamycin suppresses ROS-dependent apoptosis caused by selenomethionine in A549 lung carcinoma cells2011
- Author(s)
  MAIKO SUZUKI, MANABU ENDO, FUMIAKI SHINOHARA, SEISHI ECHIGO, HIDEMI RIKIISHI
- Journal Title
  
  Cancer Chemother Pharmacol
  
  Volume: 67(5) Issue: 5 Pages: 1129-36
- DOI
  10.1007/s00280-010-1417-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592954, KAKENHI-PROJECT-23890021
[Journal Article] Differential apoptotic response of human cancer cells to organoselenium compounds.2010
- Author(s)
  Suzuki M, Endo M, Shinohara F, Echigo S, Rikiishi H.
- Journal Title
  
  Cancer Chemo.Pharma. 66
  
  Pages: 475-484
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21791967
[Journal Article] Zebularine suppresses the apoptotic potential of 5-fluorouracil via cAMP/PKA/CREB pathway against human oral squamous cell carcinoma cells.2009
- Author(s)
  Suzuki M, Shinohara F, Endo M, Sugazaki M, Echigo S, Rikiishi H.
- Journal Title
  
  Cancer Chemo.Pharma. 64
  
  Pages: 223-232
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21791967
[Journal Article] Enhancement of cisplatin cytotoxicity by SAHA involves endoplasmic reticulum stress-mediated apoptosis in oral squamous cell carcinoma cells2009
- Author(s)
  Suzuki M, Endo M, Shinohara F, Echigo S and Rikiishi H.
- Journal Title
  
  Cancer Chemo. Pharma. (Online Pub)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19791482
[Journal Article] Enhancement of cisplatin cytotoxicity by SAHA involves endoplasmic reticulum stress-mediated apoptosis in oral squamous cell carcinoma cells.2009
- Author(s)
  Suzuki M, Endo M, Shinohara F, Echigo S, Rikiishi H.
- Journal Title
  
  Cancer Chemo.Pharma. 64
  
  Pages: 1115-1122
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21791967
[Journal Article] Zebularine suppresses the apoptotic potential of 5-fluorouracil via cAMP/PKA/CREB pathway against human oral squamous cell carcinoma cells2008
- Author(s)
  Suzuki M, Shinohara F, Endo M, Sugazaki M, Echigo S and Rikiishi H.
- Journal Title
  
  Cancer Chemo. Pharma. (Online Pub)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19791482
[Journal Article] Zebularine-induced reduction in VEGF secretion by HIF-1α degradation in oral squamous cell carcinoma2008
- Author(s)
  Suzuki M, Shinohara F and Rikiishi H.
- Journal Title
  
  Mole. Med. Repo. (1)
  
  Pages: 465-471
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19791482
[Journal Article] Epigenetic regulation of chemosensitivity to 5-fluorouracil and cisplatin by zebularine in oral squamous cell carcinoma2007
- Author(s)
  Suzuki M, Shinohara F, Nishimura K, Echigo S and Rikiishi H.
- Journal Title
  
  Int. J. Oncology (31)
  
  Pages: 1449-1456
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19791482
[Journal Article] Epigeneteic regulation of susceptibility to anti-cancer drugs in HSC-3 cells2007
- Author(s)
  Suzuki M, Shinohara F, Nishimura K, Sato Y, Echigo S and Rikiishi H.
- Journal Title
  
  Interface Oral Health Science
  
  Pages: 279-280
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19791482
[Journal Article] Chemosensitization of oral squamous cell carcinoma cells to cisplatin by histone deacetylase inhibitor, Suberoylanilide hydroxamic acid.2007
- Author(s)
  Rikiishi H, Shinohara F, Sato T, Sato Y, Suzuki M and Echigo S.
- Journal Title
  
  Int. J. Oncology (30)
  
  Pages: 1181-1188
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19791482
[Presentation] Nrf2を介した抗酸化ストレス酵素群発現は破骨細胞分化を負に制御する2014
- Author(s)
  菅崎弘幸、篠原文明、加治屋幹人、小玉哲也
- Organizer
  第35回東北骨代謝・骨粗鬆症研究会
- Place of Presentation
  仙台
- Year and Date
  2014-02-01
- Data Source
  KAKENHI-PROJECT-23592954
[Presentation] DNAメチル化酵素阻害剤による癌血管新生の抑制2013
- Author(s)
  遠藤学、篠原文明、高橋哲、長谷川博
- Organizer
  第58回　日本口腔外科学会　総会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-23592954
[Presentation] 他DNAメチル化酵素阻害剤による癌血管新生の抑制2013
- Author(s)
  遠藤学、篠原文明
- Organizer
  第58回日本口腔外科学会総会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-23592954
[Presentation] 他ヒストン脱アセチル化酵素阻害剤によるCDDPのアポトーシス増強効果の解析2012
- Author(s)
  遠藤学、篠原文明
- Organizer
  第57回日本口腔外科学会総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23592954
[Presentation] Up-regulation of 5-FU sensitivity by Cetuximab in oral squamous cell carcinoma2009
- Author(s)
  Manabu Endo, Maiko Suzuki, Fumiaki Shinohara
- Organizer
  第68回日本癌学会学術総会横浜
- Year and Date
  2009-10-03
- Data Source
  KAKENHI-PROJECT-21791967
[Presentation] Effects of Zebularine on the apoptosis of 5-Fluorouracil via cAMP/PKA/CREB pathway against human oral squamous cell carcinoma cells2009
- Author(s)
  Maiko Suzuki, Fumiaki Shinohara, Manabu Endo, Masaki Sugazaki, Seishi Echigo and Hidemi Rikiishi.
- Organizer
  The 3rd International Symposium for interface Oral Health Science
- Year and Date
  2009-03-15
- Data Source
  KAKENHI-PROJECT-19791482
[Presentation] Suppressive effects of Zebularine on 5-FU sensitivity in cancer cells2009
- Author(s)
  Maiko Suzuki, Manabu Endo, Fumiaki Shinohara
- Organizer
  第68回日本癌学会学術総会横浜
- Year and Date
  2009-10-01
- Data Source
  KAKENHI-PROJECT-21791967
[Presentation] エピジェネティクス制御剤を用いた癌血管新生の抑制2008
- Author(s)
  鈴木麻衣子、篠原文明、遠藤学、力石秀実
- Organizer
  第38回免疫学会総会
- Year and Date
  2008-12-01
- Data Source
  KAKENHI-PROJECT-19791482
[Presentation] Zebularineによる抗癌剤感受性のエピジェネティクス制御2007
- Author(s)
  鈴木麻衣子、篠原文明、西村謙太郎、力石秀実
- Organizer
  第37回免疫学会総会
- Year and Date
  2007-11-22
- Data Source
  KAKENHI-PROJECT-19791482
[Presentation] Chemical Bach1 inhibition attenuates osteoclastogenesis.
- Author(s)
  Hiroyuki Kanzaki1, 2, Fumiaki Shinohara3, Masazumi Matsuzawa1, and Yoshiki Nakamura1
- Organizer
  IADR
- Place of Presentation
  Hynes Convention Center （Boston, MA, USA)
- Year and Date
  2015-03-11 – 2015-03-14
- Data Source
  KAKENHI-PROJECT-25670841
[Presentation] Nrf2活性化による抗酸化ストレス酵素群発現誘導は破骨細胞分化阻害を介して歯の移動を抑制する
- Author(s)
  菅崎弘幸、篠原文明、中村芳樹
- Organizer
  日本矯正歯科学会
- Place of Presentation
  幕張メッセ（千葉、幕張）
- Year and Date
  2014-10-20 – 2014-10-22
- Data Source
  KAKENHI-PROJECT-25670841

1. MIYASHITA Hitoshi (70372323)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. KANZAKI Hiroyuki (30333826)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results

Shinohara Fumiaki 篠原 文明

SHINOHARA Fumiaki 篠原 文明

Research Projects

Research Products

Co-Researchers

Elucidation of pro-metastatic property of interferon degradation

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of sensitivity of oral cancer to Cetuximab and gene modification of KRAS, BRAF and PIK3CA in OSCC.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Epigenetic regulation of VEGF-C/-D in cervical lymph node metastasis.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Suppression of angiogenesis and metastasis on OSCC using epigenetical agents.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Nrf2 Activation Attenuates Both Orthodontic Tooth2015

Author(s)

Journal Title

Data Source

[Journal Article] Nuclear nrf2 induction by protein transduction attenuates osteoclastogenesis2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The Keap1/Nrf2 axis plays a role in osteoclast differentiation by regulating intracellular ROS signaling.2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Rapamycin suppresses ROS-dependent apoptosis caused by selenomethionine in A549 lung carcinoma cells2011

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Differential apoptotic response of human cancer cells to organoselenium compounds.2010

Author(s)

Journal Title

Data Source

[Journal Article] Zebularine suppresses the apoptotic potential of 5-fluorouracil via cAMP/PKA/CREB pathway against human oral squamous cell carcinoma cells.2009

Author(s)

Journal Title

Data Source

[Journal Article] Enhancement of cisplatin cytotoxicity by SAHA involves endoplasmic reticulum stress-mediated apoptosis in oral squamous cell carcinoma cells2009

Author(s)

Journal Title

Data Source

[Journal Article] Enhancement of cisplatin cytotoxicity by SAHA involves endoplasmic reticulum stress-mediated apoptosis in oral squamous cell carcinoma cells.2009

Author(s)

Journal Title

Data Source

[Journal Article] Zebularine suppresses the apoptotic potential of 5-fluorouracil via cAMP/PKA/CREB pathway against human oral squamous cell carcinoma cells2008

Author(s)

Journal Title

Data Source

[Journal Article] Zebularine-induced reduction in VEGF secretion by HIF-1α degradation in oral squamous cell carcinoma2008

Author(s)

Journal Title

Data Source

[Journal Article] Epigenetic regulation of chemosensitivity to 5-fluorouracil and cisplatin by zebularine in oral squamous cell carcinoma2007

Author(s)

Journal Title

Data Source

[Journal Article] Epigeneteic regulation of susceptibility to anti-cancer drugs in HSC-3 cells2007

Author(s)

Journal Title

Data Source

Shinohara Fumiaki 篠原文明

SHINOHARA Fumiaki 篠原文明