Kotani Takuya 小谷卓矢

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KOTANI Takuya 小谷卓矢

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Researcher Number	80411362
Other IDs
Affiliation (Current)	2025: 大阪医科薬科大学, 医学部, 特別職務担当教員(講師)
Affiliation (based on the past Project Information) *help	2022 – 2024: 大阪医科薬科大学, 医学部, 特別職務担当教員(講師) 2021: 大阪医科薬科大学, 医学部, 講師 2017 – 2020: 大阪医科大学, 医学部, 講師 2016 – 2017: 大阪医科大学, 医学部, 助教 2013 – 2014: 大阪医科大学, 医学部, 助教 2012: 大阪医科大学, 医学部, 非常勤医師
Review Section/Research Field	Principal Investigator Basic Section 54020:Connective tissue disease and allergy-related / Basic Section 53030:Respiratory medicine-related / Respiratory organ internal medicine Except Principal Investigator Basic Section 53010:Gastroenterology-related / Basic Section 54030:Infectious disease medicine-related / Laboratory medicine / Basic Section 53030:Respiratory medicine-related / Basic Section 54020:Connective tissue disease and allergy-related / Respiratory organ internal medicine
Keywords	Principal Investigator 間質性肺炎 / 脂肪幹細胞 / S100タンパク / S100蛋白 / マクロファージ / 全身性強皮症 / スタチン / 脂肪組織由来間葉系幹細胞 / 免疫学 / トランスレーショナルリサーチ / 間葉系幹細胞 / 脂肪組織由来幹細胞 / 膠原病 … More Except Principal Investigator … More マクロファージ / CCL1 / 間質性肺疾患 / S100タンパク質 / 肝硬変 / 単球 / M２b単球 / 間質性肺炎 / 関節リウマチ / 非アルコール性脂肪性肝疾患 / 胆汁酸 / NAFLD / 腸内細菌叢 / NASH / 膠原病 / 感染抵抗性 / アンチセンス / 敗血症 / M2b / M2b単球 / アルコール / GAS5 / GAS遺伝子 / 肝細胞癌 / GAS5遺伝子 / macrophage / Hepatocelullar carcinoma / バイオマーカー / クラスター解析 / ケモカイン / サイトカイン / 皮膚筋炎 / モデルマウス / 心血管病変 / 動脈硬化 / 質量分析 / 関節炎 / 質量イメージング / プロテオミクス Less

CCL1阻害による肝線維改善を目的としたマクロファージ治療の開発
- Principal Investigator
  
  朝井章
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Osaka Medical and Pharmaceutical University
Inhibitory Mechanism of Macrophage-regulatory MIKO-1 Protein in Lung Fibrosis
- Principal Investigator
  
  武内徹
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53030:Respiratory medicine-related
- Research Institution
  Osaka Medical and Pharmaceutical University
全身性強皮症に対する新規生物製剤 hMIKO-1の有効性検証とその機序の解明Principal Investigator
- Principal Investigator
  
  小谷卓矢
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54020:Connective tissue disease and allergy-related
- Research Institution
  Osaka Medical and Pharmaceutical University
胆汁酸代謝を担う腸内細菌叢の改良によるNAFLDに対する新規治療法の開発
- Principal Investigator
  
  横濱桂介
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Osaka Medical and Pharmaceutical University
Anti-inflammatory and anti-fibrotic effects of a novel macrophage-inhibitory protein in interstitial pneumonia
- Principal Investigator
  
  TAKEUCHI Tohru
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54020:Connective tissue disease and allergy-related
- Research Institution
  Osaka Medical and Pharmaceutical University
CCL1の阻害による肝硬変の感染抵抗性改善効果について
- Principal Investigator
  
  土本雄亮
- Project Period (FY)
  2020 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54030:Infectious disease medicine-related
- Research Institution
  Osaka Medical and Pharmaceutical University
CD10＋CD19ー細胞によるM2b単球誘導機序の解明
- Principal Investigator
  
  朝井章
- Project Period (FY)
  2019 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54030:Infectious disease medicine-related
- Research Institution
  Osaka Medical and Pharmaceutical University
GAS5 gene therapy on macrophage for hapatocellular carcinoma
- Principal Investigator
  
  Ohama Hideko
- Project Period (FY)
  2018 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Osaka Medical and Pharmaceutical University
脂肪組織由来幹細胞とスタチン製剤を用いた間質性肺炎マウスに対する治療効果の検討Principal Investigator
- Principal Investigator
  
  小谷卓矢
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53030:Respiratory medicine-related
- Research Institution
  Osaka Medical College
Elucidation of mechanism and disease-specific biomarkers of atherosclerosis in rheumatoid arthritis
- Principal Investigator
  
  TAKEUCHI Tohru
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Laboratory medicine
- Research Institution
  Osaka Medical College
Elucidation of pathophysiological mechanism of interstitial pneumonia in dermatomyositis and biomarker mining for its therapeutic control
- Principal Investigator
  
  MAKINO Shigeki
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Osaka Medical College
Adipose-derived stem cell transplantation in a mouse model of bleomycin-induced interstitial pneumoniaPrincipal Investigator
- Principal Investigator
  
  Kotani Takuya
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Osaka Medical College
Profile analysis of disease-related markers in synovial tissues of rheumatoid arthritis using imaging mass spectrometry
- Principal Investigator
  
  TAKEUCHI Tooru
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Laboratory medicine
- Research Institution
  Osaka Medical College

All 2023 2022 2019 2018 2017

All Journal Article Presentation Patent

[Journal Article] Human MIKO-1, a Hybrid Protein That Regulates Macrophage Function, Suppresses Lung Fibrosis in a Mouse Model of Bleomycin-Induced Interstitial Lung Disease2022
- Author(s)
  Kotani Takuya、Ikemoto Masaki、Matsuda Shogo、Masutani Ryota、Takeuchi Tohru
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 23 Issue: 17 Pages: 9669-9669
- DOI
  10.3390/ijms23179669
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K08450
[Journal Article] Chemokine profiles of interstitial pneumonia in patients with dermatomyositis: a case control study2017
- Author(s)
  Oda Katsuhiro、Kotani Takuya、Takeuchi Tohru、Ishida Takaaki、Shoda Takeshi、Isoda Kentaro、Yoshida Shuzo、Nishimura Yasuichiro、Makino Shigeki
- Journal Title
  
  Scientific Reports
  
  Volume: 7 Issue: 1 Pages: 1635-1635
- DOI
  10.1038/s41598-017-01685-5
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K09565
[Journal Article] Anti-inflammatory and anti-fibrotic effects of intravenous adipose-derived stem cell transplantation in a mouse model of bleomycin-induced interstitial pneumonia2017
- Author(s)
  Kotani Takuya、Masutani Ryota、Suzuka Takayasu、Oda Katsuhiro、Makino Shigeki、Ii Masaaki
- Journal Title
  
  Scientific Reports
  
  Volume: 7 Issue: 1 Pages: 4222-4222
- DOI
  10.1038/s41598-017-15022-3
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K19470
[Patent] 間質性肺疾患の治療のための医薬組成物2023
- Inventor(s)
  武内徹、小谷卓矢、池本正生
- Industrial Property Rights Holder
  学校法人大阪医科薬科大学
- Industrial Property Rights Type
  特許
- Filing Date
  2023
- Data Source
  KAKENHI-PROJECT-21K08450
[Patent] 間質性肺疾患の治療のための医薬組成物2023
- Inventor(s)
  武内徹、小谷卓矢、池本正生
- Industrial Property Rights Holder
  学校法人大阪医科薬科大学
- Industrial Property Rights Type
  特許
- Filing Date
  2023
- Data Source
  KAKENHI-PROJECT-21K08450
[Presentation] Simvastatin-conjugated nanoparticle enhances the therapeutic effect of adipose-derived stem cells on interstitial lung disease2019
- Author(s)
  Takuya Kotani, Masaaki Ii, Takayasu Suzuka, Yumiko Wada, Koji Nagai, Tohru Takeuchi, Shigeki Arawaka.
- Organizer
  欧州リウマチ学会 (EULAR 2019)
- Data Source
  KAKENHI-PROJECT-18K08160
[Presentation] シンバスタチンPLGA粒子抱合脂肪組織由来幹細胞の間質性肺炎モデルマウスに対する治療効果の検討2019
- Author(s)
  小谷卓矢，鈴鹿隆保, 永井孝治, 和田祐美子, 武内徹, 荒若繁樹，伊井正明
- Organizer
  第18回日本再生医療学会
- Data Source
  KAKENHI-PROJECT-18K08160
[Presentation] シンバスタチンPLGA粒子抱合脂肪組織由来幹細胞の間質性肺炎モデルマウスに対する治療効果の検討2018
- Author(s)
  小谷卓矢
- Organizer
  第18回日本再生医療学会総会
- Data Source
  KAKENHI-PROJECT-18K08160
[Presentation] 脂肪組織由来幹細胞を用いた間質性肺炎に対する新規治療法のモデルマウスにおける研究2018
- Author(s)
  小谷卓矢、鈴鹿隆保、小田勝大、武内徹、槇野茂樹、荒若繁樹
- Organizer
  第62回日本リウマチ学会総会
- Data Source
  KAKENHI-PROJECT-16K19470
[Presentation] 皮膚筋炎合併間質性肺炎におけるケモカインと病態および予後との検討2017
- Author(s)
  小田勝大、小谷卓矢、武内徹、石田貴昭、庄田武司、礒田健太郎、吉田周造、槇野茂樹
- Organizer
  第61回リウマチ学会総会・学術集会
- Place of Presentation
  福岡
- Year and Date
  2017-04-20
- Data Source
  KAKENHI-PROJECT-16K09565
[Presentation] 脂肪組織由来幹細胞の静脈投与はブレオマイシン誘発肺障害マウスの肺炎症と線維化を細胞数依存性に抑制する2017
- Author(s)
  小谷卓矢、伊井正明
- Organizer
  第16回日本再生医療学会総会
- Data Source
  KAKENHI-PROJECT-16K19470
[Presentation] Simvastatin-conjugated nanoparticle enhances the therapeutic effect of adipose-derived stem cells on interstitial lung disease2017
- Author(s)
  Takuya Kotani、Masaaki Ii
- Organizer
  International Society for Stem Cell Research Annual Meeting 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K19470

1. 朝井章 (30622146)

# of Collaborated Projects: 7 results

# of Collaborated Products: 0 results
2. TAKEUCHI Tooru (10330078)

# of Collaborated Projects: 6 results

# of Collaborated Products: 3 results
3. Ohama Hideko (60794782)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
4. 鈴鹿隆保 (50748225)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
5. MAKINO Shigeki (20268204)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
6. Ii Masaaki (10442922)

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
7. 土本雄亮 (00794760)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. 池本正生 (80144385)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
9. 松田翔悟 (00898489)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
10. ISHIDA takaaki

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
11. ODA katsuhiro

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
12. KONMA junichi

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
13. NAKANISHI Toyofumi (10247843)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 吉田周造 (40530697)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 永井孝治 (30572458)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 秦健一郎 (90536921)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 金沢徹文 (20534100)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 岡田光貴 (80747569)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 横濱桂介 (70880110)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 大矢裕一 (10213886)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. 西川知宏 (10992779)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. 西川浩樹 (30769609)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. 後昂佑 (50991973)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Kotani Takuya 小谷 卓矢

KOTANI Takuya 小谷 卓矢

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全身性強皮症に対する新規生物製剤 hMIKO-1の有効性検証とその機序の解明Principal Investigator

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脂肪組織由来幹細胞とスタチン製剤を用いた間質性肺炎マウスに対する治療効果の検討Principal Investigator

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Adipose-derived stem cell transplantation in a mouse model of bleomycin-induced interstitial pneumoniaPrincipal Investigator

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[Journal Article] Human MIKO-1, a Hybrid Protein That Regulates Macrophage Function, Suppresses Lung Fibrosis in a Mouse Model of Bleomycin-Induced Interstitial Lung Disease2022

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[Journal Article] Chemokine profiles of interstitial pneumonia in patients with dermatomyositis: a case control study2017

Author(s)

Kotani Takuya 小谷卓矢

KOTANI Takuya 小谷卓矢