OSADA Ryosuke 長田亮介

Researcher Number	80418722
Affiliation (based on the past Project Information) *help	2007 – 2010: Shinshu University, Obstetrics and gynecology, Assistant Professor 2008: 信州大学, 医学部・附属病院, 助教 2006: 信州大学, 医学部附属病院, 助手
Review Section/Research Field	Except Principal Investigator Obstetrics and gynecology
Keywords	Except Principal Investigator E-cadherin / 卵巣癌 / HIF / invasion / Ovarian Cancer / Hvnoxia / 低酸素 / 浸潤能 / E-カドヘリン / 低酸素環境 … More / INT6 / VHL / Int6 / Hedgehog / RhoA / Snail / S100A4 / TGFβ / メチル化 / 低分子化合物 / マイクロアレイ / シグナル伝達 / エピジェネティックス / 播種性転移 Less

The expression of mammalian tumor suppressor, Int6 and hypoxia inducible factor(HIF)-2α in ovarian carcinomasPrincipal Investigator
- Principal Investigator
  
  OHIRA Satoshi, 長田亮介
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Shinshu University
Analysis of signaling pathways in peritoneal dissemination of ovarian cancer, which leads to investigation for their suppressor reagents.
- Principal Investigator
  
  KONISHI Ikuo
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Kyoto University
Hypoxia increased ovarian cancer invasiveness with increased E-cadherin transcriptional repressor Snail
- Principal Investigator
  
  HORIUCHI Akiko
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Shinshu University

All 2010 2009 2008 2007 2006

All Journal Article Presentation

[Journal Article] Fetal goitrous hypothyroidism due to maternal thyroid stimulation-blocking antibody : a case report.2010
- Author(s)
  Ohira S, Miyake M, Kobara H, Kikuchi N, Osada R, Ashida T, Hirabayashi K, Nishio S, Kanai M, Shiozawa T
- Journal Title
  
  Fetal Diagn Ther. 28(4)
  
  Pages: 220-224
- NAID
  120007107374
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591941
[Journal Article] Overexpression of RhoA enhances peritoneal dissemination : RhoA suppression with Lovastatin may be useful for ovarian cancer.2009
- Author(s)
  Horiuchi A, Kikuchi N, Osada R, WC, Hayashi A, Nikaido T, Konishi I
- Journal Title
  
  Cancer Sci. 99(12)
  
  Pages: 2532-2539
- NAID
  10024014761
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591941
[Journal Article] Changes in the expression of E-cadherin repressors, Snail, Slug, SIP1, and Twist, in the development and progression of ovarian carcinoma : the important role of Snail in ovarian tumorigenesis and progression.2009
- Author(s)
  Yoshida J, Horiuchi A, Kikuchi N, Hayashi A, Osada R, Ohira S, Shiozawa T, Konishi I.
- Journal Title
  
  Med Mol Morphol. 42(2)
  
  Pages: 82-91
- NAID
  10025859893
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591941
[Journal Article] Changes in the expression of E-cadherin repressors, Snail Slug, SIP1, and Twist, in the development and progression of ovarian carcinoma : the important role of Snail in ovarian tumorigenesis and progression.2009
- Author(s)
  Yoshida J, Horiuchi A, Kikuchi N, Hayashi A, Osada R, Ohira S, Shiozawa T, Konishi I.
- Journal Title
  
  Med Mol Morphol. 42
  
  Pages: 82-91
- NAID
  10025859893
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591941
[Journal Article] Overexpression of RhoA enhances peritoneal dissemination : RhoA suppression with Lovastatin may be useful for ovarian cancer.2008
- Author(s)
  Horiuchi A, Kikuchi N, Osada R, Wang C, Hayashi A, Nikaido T, Konishi I.
- Journal Title
  
  Cancer Science 99
  
  Pages: 2532-2539
- NAID
  10024014761
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390426
[Journal Article] Overexpression of RhoA enhances peritoneal dissemination: RhoA suppression with Lovastatin may be useful for ovarian cancer2008
- Author(s)
  Horiuchi A, Kikuchi N, Osada R, Wang C, Hayashi A, Nikaido T, Konishi I
- Journal Title
  
  Cancer Sci 99
  
  Pages: 2532-9
- NAID
  10024014761
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390426
[Journal Article] I. A new technique using a rubber balloon in emergency second trimester cerclage for fetal membrane prolapse2008
- Author(s)
  Kanai M, Ashida T, Ohira S, Osada R, Konishi I
- Journal Title
  
  J Obstet Gynaecol Res 34
  
  Pages: 935-40
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390426
[Journal Article] Hedgehog signal pathway is activated in ovarian carcinomas correlating with the cell proliferation : Its inhibition leads to the growth suppression and apoptosis2007
- Author(s)
  Chen, X., Horiuchi, A., Kikuchi, N., Osada, R., Yoshida, Y., Shiozawa, T., Konishi, I
- Journal Title
  
  Cancer Sri 98
  
  Pages: 68-76
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591828
[Journal Article] Hedgehog signal pathway is activated in ovarian carcinomas correlating with the cell proliferation: Its inhibition leads to the growth suppression and apoptosis.2007
- Author(s)
  Chen X, Horiuchi A, Kikuchi N, Osada R, Yoshida Y, Shiozawa T, Konishi I
- Journal Title
  
  Cancer Science 98
  
  Pages: 68-76
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18591828
[Journal Article] Expression of hypoxia-inducible factor-la (HIF-1α), HIF-2α and von Hippel-Lindau (VHL) protein in epithelial ovarian neoplasms: Nuclear expression of HIF-1α is an independent prognostic factor in ovarian carcinoma.2007
- Author(s)
  Osada R, Horiuchi A, Kikuchi N, Yoshida J, Hayashi A, Ota M, Katsuyama M, Mellilo G, Konishi I
- Journal Title
  
  Human Pathology 38
  
  Pages: 1310-1320
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390426
[Journal Article] Expression of hypoxia-inducible factor-1α (HIF-1α), HIF-2α and von Hippel-Lindau (VHL) protein in epithelial ovarian neoplasms and alleic loss of VHL gene : Nuclear expression of HIF-1α is an independent prognostic factor in ovarian carcinoma2007
- Author(s)
  Osada, R., Horiuchli, A., Kikuchi, N., Yoshida, I., Hayashi, A., Ota, M., Katsuyama, Y., Melillo, G., Konishi, I
- Journal Title
  
  Hum Pathol 38
  
  Pages: 1310-20
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591828
[Journal Article] Hedgehog signal pathway is activated in ovarian carcinomas correlating with the cell proliferation : Its inhibition leads to the growth suppression and apoptosis.2007
- Author(s)
  Chen X, Horiuchi A, Kikuchi N, Osada R, Yoshida Y, Shiozawa T, Konishi I
- Journal Title
  
  Cancer Science 98
  
  Pages: 68-76
- Data Source
  KAKENHI-PROJECT-18591828
[Journal Article] Hedgehog signal pathway is activated in ovarian carcinomas correlating with the cell proliferation: Its inhibition leads to the growth suppression and apoptosis.2007
- Author(s)
  Chen XJ, Horiuchi A, Kikuchi N, Osada R, Yoshida J, Shiozawa T, Konishi I
- Journal Title
  
  Cancer Science 98
  
  Pages: 68-76
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390426
[Journal Article] Expression of hypoxia-inducible factor 1alpha, hypoxia-inducible factor 2alpha, and von Hippel-Lindau protein in epithelial ovarian neoplasms and allelic loss of von Hippel-Lindau gene: nuclear expression of hypoxia-inducible factor 1alpha is an independent prognostic factor in ovarian carcinoma.2007
- Author(s)
  Osada R, Horiuchi A, Kikuchi N, Yoshida J, Hayashi A, Ota M, Katsuyama Y, Mellilo G, Konishi I.
- Journal Title
  
  Hum Pathol. 38
  
  Pages: 1310-20
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18591828
[Journal Article] Expression of hypoxia-inducible factor 1alpha, hypoxia-inducible factor 2alpha, and von Hippel-Lindau protein in epithelial ovarian neoplasms and allelic loss of von Hippel-Lindau gene: nuclear expression of hypoxia-inducible factor 1alpha is an independent prognostic factor in ovarian carcinoma2007
- Author(s)
  Osada R, Horiuchi A, Kikuchi N, Yoshida J, Hayashi A, Ota M, Katsuyama Y, Melillo G, Konishi I.
- Journal Title
  
  Hum Pathol 38
  
  Pages: 1310-20
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390426
[Journal Article] BRCA1 expression is an important biomarker for chemosensitivity : Suppression of BRCA1 increases the apoptosis via up-regulation of p53 and p21 during cisplatin treatment in ovarian cancer cells.2006
- Author(s)
  Horiuchi A, Wang C, Kikuchi N, Osada R, Nikaido T, Konishi I
- Journal Title
  
  Biomaker Insight 234・9
  
  Pages: 234-345
- Data Source
  KAKENHI-PROJECT-18591828
[Journal Article] Nuclear Expression of S100A4 is Associated with Aggressive Behavior of Epithelial Ovarian Carcinoma : An Important Autocrine/Paracrine Factor in Tumor Progression2006
- Author(s)
  Kikuchi, N., Horiuchi, A., Osada, R., Imai, T., Wang, C., Chen, X., Konishi, I
- Journal Title
  
  Cancer Sci 98
  
  Pages: 1061-9
- NAID
  10019378155
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591828
[Journal Article] BRCA1 expression is an important biomarker for chemosensitivity : Suppression of BRCA1 increases the apoptosis via up-regulation of p53 and p21 during cisplatin treatment in ovarian cancer cells2006
- Author(s)
  Horiuchi, A., Wang, C., Kikuchi, N., Osada, R., Nikaido, T., Konishi, I
- Journal Title
  
  Biomaker Insight 2
  
  Pages: 49-59
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591828
[Journal Article] Nuclear Nuclear expression of S100A4 is associated with aggressive behavior of epithelial ovarian carcinoma: an important autocrine/paracrine factor in tumor progression.2006
- Author(s)
  Kikuchi N, Horiuchi A, Osada R, Imai T, Wang C, Chen X, Konishi I.
- Journal Title
  
  Cancer Science 97
  
  Pages: 1061-9
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18591828
[Journal Article] Expression of semaphorins, vascular endothelial growth factor, and their common receptor neuropilins and alleic loss of semaphorin locus in epithelial ovarian neoplasms: increased ratio of vascular endothelial growth factor to semaphorin is a poor prognostic factor in ovarian carcinomas.2006
- Author(s)
  Osada R, Horiuchi A, Kikuchi N, Ohira S, Ota M, Katsuyama Y, Konishi I.
- Journal Title
  
  Hum Pathol. 37
  
  Pages: 1414-25
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18591828
[Journal Article] Expression of semaphorins (SEMA), VEGF and their common receptor neuropilins, and alleic loss of SEMA locus in epithelial ovarian neoplasms : Increased VEGF/SEMA ratio is a poor prognostic factor in ovarian carcinomas2006
- Author(s)
  Osada, R., Horiuchi, A., Kikuchi, N., Ohira, S., Ota, M., Katsuyama, Y., Konishi, I
- Journal Title
  
  Hum Pathol 37
  
  Pages: 1414-25
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591828
[Journal Article] Expression of semaphorins, vascular endothelial growth factor, and their common receptor neuropilins and alleic loss of semaphorin locus in epithelial ovarian neoplasms : increased ratio of vascular endothelial growth factor to semaphorin is a poor prognostic factor in ovarian carcinomas.2006
- Author(s)
  Kikuchi N, Horiuchi A, Osada R, Imai T, Wang C, Chen X, Konishi I
- Journal Title
  
  Hum Pathol 37
  
  Pages: 1414-1425
- Data Source
  KAKENHI-PROJECT-18591828
[Journal Article] BRCA1 expression is an important biomarker for chemosensitivity: Suppression of BRCA1 increases the apoptosis via up-regulation of p53 and p21 during cisplatin treatment in ovarian cancer cells.2006
- Author(s)
  Horiuchi A, Wang C, Kikuchi N, Osada R, Nikaido T, Konishi I.
- Journal Title
  
  Biomaker Insight 9
  
  Pages: 234-345
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18591828
[Presentation] 卵巣癌における癌抑制遺伝子Int6およびhypoxia induciblefactor(HIF)-αサブユニット発現の検討2010
- Author(s)
  長田亮介、堀内晶子、林晶子、布施谷千穂、菊地範彦、三橋祐布子、塩沢丹里
- Organizer
  第62回日本産科婦人科学会総会・学術講演会
- Place of Presentation
  東京
- Year and Date
  2010-04-23
- Data Source
  KAKENHI-PROJECT-20591941
[Presentation] 卵巣癌における癌抑制遺伝子lnt6およびhypoxia inducible factor(HIF)-αサブユニット発現の検討2010
- Author(s)
  長田亮介、堀内晶子、林品子、布施谷千穂、菊地範彦、三橋祐布子、塩沢丹里
- Organizer
  第62回日本産科婦人科学会総会・学術講演会
- Place of Presentation
  東京
- Year and Date
  2010-04-23
- Data Source
  KAKENHI-PROJECT-20591941
[Presentation] 卵巣癌においてHDAC1抑制は細胞周期調節因子を介して細胞増殖を抑制する2009
- Author(s)
  林晶子、堀内晶子、長田亮介、菊地範彦、吉田順子、布施谷千穂、小西郁生、塩沢丹里
- Organizer
  第61回日本産科婦人科学会・学術講演会
- Place of Presentation
  京都
- Year and Date
  2009-04-05
- Data Source
  KAKENHI-PROJECT-20591941
[Presentation] 卵巣癌においてclass 1ヒストン脱アセチル化酵素(histone deacetylase, HDAC)のうちHDAC1が細胞増殖に重要である2008
- Author(s)
  林晶子, 堀内晶子, 長田亮介, 菊地範彦, 吉田順子, 正木千穂, 塩沢丹里, 小西郁生
- Organizer
  第60回日本産科婦人科学会・学術講演会・口演
- Place of Presentation
  横浜
- Year and Date
  2008-04-13
- Data Source
  KAKENHI-PROJECT-20591941
[Presentation] 低酸素環境卵巣癌細胞においてSlOOA4 発現はHypoxia-induciblefactor-1αを介し元進する.2008
- Author(s)
  菊地範彦、堀内晶子、林琢磨、林晶子、長田亮介、布施谷千穂、塩沢丹里、小西郁生
- Organizer
  第60回日本産科婦人科学会・学術講演会ポスター
- Place of Presentation
  東京
- Year and Date
  2008-04-15
- Data Source
  KAKENHI-PROJECT-20591941
[Presentation] 低酸素環境卵巣癌細胞においてS100A4発現はHypoxia-inducible factor-1 αを介し先進する2008
- Author(s)
  菊地範彦, 堀内晶子, 林琢磨, 林晶子, 長田亮介, 布施谷千穂, 塩沢丹里, 小西郁生
- Organizer
  第60回日本産科婦人科学会・学術講演会
- Place of Presentation
  横浜
- Year and Date
  2008-04-13
- Data Source
  KAKENHI-PROJECT-20591941
[Presentation] 正常卵巣表層上皮(OSE)および上皮性卵巣腫瘍におけるE-cadherin転写抑制因子Snail,SlugおよびTwistの発現2007
- Author(s)
  吉田順子、菊地範彦、長田亮介、林晶子、堀内晶子、小西郁生
- Organizer
  第59回日本産科婦人科学会学術講演会
- Place of Presentation
  京都
- Year and Date
  2007-04-16
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18591828

1. HORIUCHI Akiko (80334895)

# of Collaborated Projects: 3 results

# of Collaborated Products: 27 results
2. OHIRA Satoshi (90397315)

# of Collaborated Projects: 3 results

# of Collaborated Products: 4 results
3. KONISHI Ikuo (90192062)

# of Collaborated Projects: 2 results

# of Collaborated Products: 20 results
4. MANDAI Masaki (80283597)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. MATSUMURA Noriomi (20452336)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. BABA Tsukasa (60508240)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. ITO Kazuko (40303458)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. SHIOZAWA Tanri (20235493)

# of Collaborated Projects: 1 results

# of Collaborated Products: 9 results

OSADA Ryosuke 長田 亮介

Research Projects

Research Products

Co-Researchers

The expression of mammalian tumor suppressor, Int6 and hypoxia inducible factor(HIF)-2α in ovarian carcinomasPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of signaling pathways in peritoneal dissemination of ovarian cancer, which leads to investigation for their suppressor reagents.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Hypoxia increased ovarian cancer invasiveness with increased E-cadherin transcriptional repressor Snail

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Fetal goitrous hypothyroidism due to maternal thyroid stimulation-blocking antibody : a case report.2010

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Overexpression of RhoA enhances peritoneal dissemination : RhoA suppression with Lovastatin may be useful for ovarian cancer.2009

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Changes in the expression of E-cadherin repressors, Snail, Slug, SIP1, and Twist, in the development and progression of ovarian carcinoma : the important role of Snail in ovarian tumorigenesis and progression.2009

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Changes in the expression of E-cadherin repressors, Snail Slug, SIP1, and Twist, in the development and progression of ovarian carcinoma : the important role of Snail in ovarian tumorigenesis and progression.2009

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Overexpression of RhoA enhances peritoneal dissemination : RhoA suppression with Lovastatin may be useful for ovarian cancer.2008

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Overexpression of RhoA enhances peritoneal dissemination: RhoA suppression with Lovastatin may be useful for ovarian cancer2008

Author(s)

Journal Title

NAID

Data Source

[Journal Article] I. A new technique using a rubber balloon in emergency second trimester cerclage for fetal membrane prolapse2008

Author(s)

Journal Title

Data Source

[Journal Article] Hedgehog signal pathway is activated in ovarian carcinomas correlating with the cell proliferation : Its inhibition leads to the growth suppression and apoptosis2007

Author(s)

Journal Title

Description

Data Source

[Journal Article] Hedgehog signal pathway is activated in ovarian carcinomas correlating with the cell proliferation: Its inhibition leads to the growth suppression and apoptosis.2007

Author(s)

Journal Title

Description

Data Source

[Journal Article] Expression of hypoxia-inducible factor-la (HIF-1α), HIF-2α and von Hippel-Lindau (VHL) protein in epithelial ovarian neoplasms: Nuclear expression of HIF-1α is an independent prognostic factor in ovarian carcinoma.2007

Author(s)

Journal Title

Data Source

[Journal Article] Expression of hypoxia-inducible factor-1α (HIF-1α), HIF-2α and von Hippel-Lindau (VHL) protein in epithelial ovarian neoplasms and alleic loss of VHL gene : Nuclear expression of HIF-1α is an independent prognostic factor in ovarian carcinoma2007

Author(s)

Journal Title

Description

Data Source

[Journal Article] Hedgehog signal pathway is activated in ovarian carcinomas correlating with the cell proliferation : Its inhibition leads to the growth suppression and apoptosis.2007

Author(s)

Journal Title

Data Source

[Journal Article] Hedgehog signal pathway is activated in ovarian carcinomas correlating with the cell proliferation: Its inhibition leads to the growth suppression and apoptosis.2007

OSADA Ryosuke 長田亮介