Naito Takafumi 内藤隆文

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NAITO Takafumi 内藤隆文

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Researcher Number	80422749
Other IDs	https://orcid.org/0000-0002-7447-3789
Affiliation (Current)	2024: 信州大学, 学術研究院医学系(医学部附属病院), 教授
Affiliation (based on the past Project Information) *help	2021 – 2024: 信州大学, 学術研究院医学系(医学部附属病院), 教授 2017 – 2022: 浜松医科大学, 医学部附属病院, 特任准教授 2010 – 2016: Hamamatsu University School of Medicine, 医学部附属病院, 副薬剤部長 2009: Hamamatsu University School of Medicine, 医学部附属病院, 薬剤主任 2008: Hamamatsu University School of Medicine, 医学部・附属病院, 薬剤主任
Review Section/Research Field	Principal Investigator Medical pharmacy / Basic Section 47060:Clinical pharmacy-related Except Principal Investigator Basic Section 47060:Clinical pharmacy-related / Medical pharmacy / Medium-sized Section 52:General internal medicine and related fields
Keywords	Principal Investigator 薬物動態 / 遺伝子多型 / がん性疼痛 / オピオイド / オキシコドン / バイオマーカー / 薬物代謝 / 炎症性サイトカイン / 悪液質 / 有害作用 … More / 緩和医療 / オレキシン受容体拮抗薬 / がん / トランスポーター / 周産期 / 有機アニオン輸送ポリペプチド / 肝取り込みトランスポーター / 妊娠 / 甲状腺ホルモン / 個別化薬物療法 / CYP3A / エピジェネティック因子 / CYP3A4/5 / マイクロRNA / 4β水酸化コレステロール / 血清バイオマーカー / CYP2D6 / CYP3A4 / 炎症 / 薬物代謝酵素 / がん悪液質 / 中枢症状 / サイトカイン / TDM / 代謝物 / 制吐薬 / プロラクチン / オピオイド誘発性嘔吐 / オピオイドμ1受容体 / ドパミンD2受容体 / プロクロルペラジン / テーラーメイド医療 / フェンタニル / オピオイドローテーション / オーダーメード医療 … More Except Principal Investigator 薬物動態 / がん悪液質 / オピオイド / がん性疼痛 / 炎症性サイトカイン / 有害作用 / プレガバリン / トラマドール / 神経障害性疼痛 / 遺伝子多型 / 代謝物 / 緩和医療 / 脳移行 / 脳血管障害 / 抗てんかん薬 / AMPA受容体拮抗薬 / がん病態生理 / オピオイド系鎮痛薬 / 薬物輸送担体 / 薬物代謝酵素 / がん性疼痛緩和 / オピオイド誘発性便秘 / SPECT / モデルラット / モデルマウス / IL-6 / 脳 / PET / ラットモデル / 個別化薬物療法 / 神経障害性疼痛治療薬 / デュロキセチン / バイオマーカー / 鎮痛補助薬 / フェンタニル / 忍容性 / 薬物代謝 / 病期 / 鎮痛効果 / がん病期 / 制酸剤 / 遺伝子変異 / 薬物間相互作用 / ガバペンチン / CYP2D6 / α1酸性糖タンパク / アルブミン / 有害反応 / 遊離形分率 / 耐性形成 / 悪液質 / 遺伝子多 / オーダーメイド医療 / オキシコドン / オピオイド鎮痛薬 Less

脳血管障害時におけるAMPA受容体拮抗薬の中枢移行および薬効・有害作用の個人差の解明
- Principal Investigator
  
  川上純一
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Hamamatsu University School of Medicine
Investigation of interindividual variability in pharmacokinetics of and clinical responses to orexin receptor antagonists in cancer statusPrincipal Investigator
- Principal Investigator
  
  内藤隆文
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Shinshu University
Investigation of interindividual factors determining the clinical effects of peripherally-acting mu-opioid receptor antagonist under cancer conditions
- Principal Investigator
  
  川上純一
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Hamamatsu University School of Medicine
Kinetic analyses of thyroid hormone based on hepatic uptake transporter activity during the perinatal periodPrincipal Investigator
- Principal Investigator
  
  内藤隆文
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Shinshu University
  Hamamatsu University School of Medicine
Elucidation of Pathological function of central dysfunction in cancer cachexia by imaging science
- Principal Investigator
  
  Magata Yasuhiro
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 52:General internal medicine and related fields
- Research Institution
  Hamamatsu University School of Medicine
Investigation of interindividual variability in pharmacokinetics of and clinical responses to neuropathic pain medications in cancer patients
- Principal Investigator
  
  Kawakami Junichi
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Hamamatsu University School of Medicine
Prediction of opioid analgesics pharmacokinetics using the biomarkers of drug metabolizing enzyme activity in cancer patientsPrincipal Investigator
- Principal Investigator
  
  NAITO TAKAFUMI
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  Hamamatsu University School of Medicine
Prediction of interindividual variations in pain relief and adverse effects of opioid analgesics based on cancer disease stage
- Principal Investigator
  
  Kawakami Junichi
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  Hamamatsu University School of Medicine
Investigation of interindividual factors determining the pain relief and adverse effects of opioid analgesics in cancer cachexiaPrincipal Investigator
- Principal Investigator
  
  NAITO TAKAFUMI
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  Hamamatsu University School of Medicine
Investigation of interindividual variability in pharmacokinetics of and clinical responses to analgesics for cancer pain relief
- Principal Investigator
  
  KAWAKAMI Junichi
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  Hamamatsu University School of Medicine
Investigation of relationship between the pharmacokinetics of and clinical responses to prochlorperazine in patients receiving opioidsPrincipal Investigator
- Principal Investigator
  
  NAITO Takafumi
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Medical pharmacy
- Research Institution
  Hamamatsu University School of Medicine
Investigation of interindividual variability in pharmacokinetics of and clinical responses to opioid analgesics in cancer pain patients
- Principal Investigator
  
  KAWAKAMI Junichi
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  Hamamatsu University School of Medicine
Establishment of optimal conversion ratios of opioid analgesics based on genetic polymorphisms in individual palliative carePrincipal Investigator
- Principal Investigator
  
  NAITO Takafumi
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Medical pharmacy
- Research Institution
  Hamamatsu University School of Medicine

All 2023 2021 2020 2019 2017 2016 2014 2012 2011 2010 2009

All Journal Article Presentation

[Journal Article] A reversed-phase mode LC-MS/MS method using a polysaccharide chiral selector for simultaneous quantitation of each enantiomer of tramadol and its metabolites in human plasma and evaluation of CYP-mediated stereoselective demethylation.2020
- Author(s)
  Suzuki K, Naito T, Tanaka H, Yamada Y, Itoh K, Kawakami J.
- Journal Title
  
  Ther Drug Monit
  
  Volume: － Issue: 3 Pages: 503-511
- DOI
  10.1097/ftd.0000000000000707
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08410
[Journal Article] Impact of cachexia and opioid analgesic co-treatment on pregabalin pharmacokinetics and central nervous system symptoms in cancer patients.2019
- Author(s)
  Nozomi Yoshikawa, Takafumi Naito, Tatsuya Yagi, and Junichi Kawakami
- Journal Title
  
  Therapeutic Drug Monitoring
  
  Volume: 41 Issue: 5 Pages: 591-597
- DOI
  10.1097/ftd.0000000000000634
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18H00378, KAKENHI-PROJECT-18K06746
[Journal Article] Relationships between oxycodone pharmacokinetics, central symptoms, and serum interleukin-6 in cachectic cancer patients2016
- Author(s)
  Sato H, Naito T, Ishida T, Kawakami J.
- Journal Title
  
  Eur J Clin Pharmacol
  
  Volume: 72(12) Issue: 12 Pages: 1463-1470
- DOI
  10.1007/s00228-016-2116-z
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26460194
[Journal Article] Impact of genetic and non-genetic factors on clinical responses to prochlorperazine in oxycodone-treated cancer patients.2014
- Author(s)
  Tashiro M, Naito T, Ohnishi K, Kagawa Y, Kawakami J.
- Journal Title
  
  Clin Chim Acta.
  
  Volume: 429 Pages: 175-180
- DOI
  10.1016/j.cca.2013.12.011
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591379, KAKENHI-PROJECT-23790181, KAKENHI-PROJECT-25460215
[Journal Article] Simultaneous determination of prochlorperazine and its metabolites in human plasma using isocratic liquid chromatography tandem mass spectrometry2012
- Author(s)
  Tashiro M, Naito T, Kagawa Y, Kawakami J
- Journal Title
  
  Biomed Chromatogr
  
  Volume: 26 Issue: 6 Pages: 754-760
- DOI
  10.1002/bmc.1725
- Data Source
  KAKENHI-PROJECT-23790181
[Journal Article] Impact of Concomitant Antacid Administration on Gabapentin Plasma Exposure and Oral Bioavailability in Healthy Adult Subjects2012
- Author(s)
  Yagi T, Naito T, Mino Y, Umemura K, Kawakami J.
- Journal Title
  
  Drug Metabolism and Pharmacokinetics
  
  Volume: 27 Issue: 2 Pages: 248-254
- DOI
  10.2133/dmpk.DMPK-11-RG-108
- NAID
  130004463244
- ISSN
  1347-4367, 1880-0920
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590186
[Journal Article] Impact of cachexia on pharmacokinetic disposition of and clinical responses to oxycodone in cancer patients2012
- Author(s)
  Naito T, Tashiro M, Yamamoto K, Ohnishi K, Kagawa Y, Kawakami J
- Journal Title
  
  Eur J Clin Pharmacol
  
  Volume: (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590155
[Journal Article] CYP3A5* 3 affects plasma disposition of noroxycodone and dose escalation in cancer patients receiving oxycodone2011
- Author(s)
  Naito T, Takashina Y, Yamamoto K, Tashiro M, Ohnishi K, Kagawa Y, Kawakami J
- Journal Title
  
  J Clin Pharmacol
  
  Volume: 51 Pages: 1529-1538
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590155
[Journal Article] CYP3A5*3 affects plasma disposition of noroxycodone and dose escalation in cancer patients receiving oxycodone.2011
- Author(s)
  Naito T, Takashina Y, Yamamoto K, Tashiro M, Ohnishi K, Kagawa Y, Kawakami J.
- Journal Title
  
  J Clin Pharmacol in press
- Data Source
  KAKENHI-PROJECT-20790132
[Journal Article] Validated LC coupled to ESI-MS/MS analysis for fentanyl in human plasma and UV analysis in applied reservoir transdermal patches using a simple and rapid procedure.2009
- Author(s)
  Takashina Y, Naito T, Mino Y, Kagawa Y, Kawakami J.
- Journal Title
  
  J Clin Pharm Ther 34
  
  Pages: 523-529
- Data Source
  KAKENHI-PROJECT-20790132
[Presentation] がん病態時における血中ナルデメジン濃度に及ぼすCYP3A5およびABCB1の遺伝子多型と悪液質進行の影響2023
- Author(s)
  中津川瑛美、内藤隆文、柴田海斗、前川真人、川上純一
- Organizer
  第143回日本薬学会年会
- Data Source
  KAKENHI-PROJECT-21K06664
[Presentation] メタルフリーPEEKカラムを用いたOATP1B基質胆汁酸硫酸抱合体のLC-MS/MS同時定量法の開発2021
- Author(s)
  黒澤優子, 内藤隆文, 前川真人, 伊東宏晃, 川上純一
- Organizer
  第42回日本臨床薬理学会学術総会
- Data Source
  KAKENHI-PROJECT-20K07175
[Presentation] がん患者におけるオピオイド系鎮痛薬の体内動態および臨床効果に及ぼす遺伝的要因2021
- Author(s)
  内藤隆文
- Organizer
  第14回日本緩和医療薬学会年会
- Data Source
  KAKENHI-PROJECT-18K06746
[Presentation] 頭頸部がん患者におけるトラマドール及び代謝物の光学異性体の血中動態とCYP2D6のactivity scoreとの関係解析.2020
- Author(s)
  鈴木光路, 内藤隆文, 田中達也, 山田康秀, 伊藤邦彦, 川上純一.
- Organizer
  第140回日本薬学会年会
- Data Source
  KAKENHI-PROJECT-17K08410
[Presentation] デュロキセチン服用妊婦における臍帯血・母体血中薬物濃度と新生児薬物離脱症候群との関係2020
- Author(s)
  田口怜奈, 内藤隆文, 鈴木光路, 伊東宏晃, 川上純一
- Organizer
  第30回日本医療薬学会年会
- Data Source
  KAKENHI-PROJECT-18K06746
[Presentation] An enantiomeric quantitation of tramadol and its metabolites in human plasma and evaluation of cytochrome P450-mediated stereoselective demethylation.2019
- Author(s)
  Suzuki K, Naito T, Tanaka H, Yamada Y, Itoh K, Kawakami J.
- Organizer
  The 120th Annual Meeting of the American Society for Clinical Pharmacology and Therapeutics (ASCPT2019)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08410
[Presentation] がん患者におけるトラマドールとその脱メチル代謝物の血中動態に及ぼすCYP2D6およびCYP2B6の遺伝子変異の影響2017
- Author(s)
  田中達也, 内藤隆文, 佐藤聖, 川上純一
- Organizer
  第38回日本臨床薬理学会年会
- Data Source
  KAKENHI-PROJECT-15K08070
[Presentation] Impact of CYP2D6 phenotype on tramadol pharmacokinetics and metabolic pathways in cancer patients2017
- Author(s)
  Tanaka H, Naito T, Sato H, Kawakami J
- Organizer
  13th Congress of the European Association for Clinical Pharmacology and Therapeutics (EACPT2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08070
[Presentation] がん悪液質の病態時における血清IL-6 の濃度上昇とオキシコドンの血中動態および中枢症状発現との関係2016
- Author(s)
  佐藤聖, 内藤隆文, 石田卓矢, 川上純一.
- Organizer
  第26回日本医療薬学会年会
- Place of Presentation
  京都市
- Year and Date
  2016-09-17
- Data Source
  KAKENHI-PROJECT-26460194
[Presentation] Impact of serum albumin level on free oxycodone pharmacokinetics, dose escalation, and central adverse reaction in cancer patients2011
- Author(s)
  Naito T, Tashiro M, Yamamoto K, Kagawa Y, Kawakami J
- Organizer
  10th Congress of the European Association for Clinical Pharmacology and Therapeutics
- Place of Presentation
  Budapest, Hungary
- Data Source
  KAKENHI-PROJECT-21590155
[Presentation] がん患者におけるフェンタニル貼付剤への切り替え後の鎮痛効果及び有害作用に及ぼすCYP3A5とABCB1の遺伝子変異の影響2011
- Author(s)
  高科嘉章, 内藤隆文, 見野靖晃, 大西一功, 川上純一
- Organizer
  第131回日本薬学会年会
- Place of Presentation
  静岡
- Data Source
  KAKENHI-PROJECT-20790132
[Presentation] Relationships between prochlorperazine pharmacokinetics and Its clinical responses based on DRD2 gene polymorphisms in cancer patients receiving opioid analgesics2011
- Author(s)
  Tashiro M, Naito T, Takashina Y, Kagawa Y, Kawakami J
- Organizer
  10th Congress of the European Association for Clinical Pharmacology and Therapeutics
- Place of Presentation
  Budapest, Hungary
- Data Source
  KAKENHI-PROJECT-23790181
[Presentation] がん患者におけるフェンタニル貼付剤への切り替え俊の鎮痛効果及び有害作用に及ぼすCYP3A5とABCB1の遺伝子変異の影響2011
- Author(s)
  高科嘉章、内藤隆文, ら
- Organizer
  第131回日本薬学会年会
- Place of Presentation
  静岡市
- Year and Date
  2011-03-30
- Data Source
  KAKENHI-PROJECT-20790132
[Presentation] Impact of cachexia on pharmacokinetic disposition of and clinical responses to oxycodone in cancer patients2011
- Author(s)
  Naito T, Tashiro M, Yamamoto K, Ohnishi K, Kagawa Y, Kawakami J
- Organizer
  第5回次世代を担う若手医療薬科学シンポジウム
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-21590155
[Presentation] がん患者におけるプロクロルペラジンの制吐作用および有害作用に及ぼすDRD2の遺伝子変異の影響2011
- Author(s)
  田代将貴,内藤隆文,賀川義之,川上純一
- Organizer
  第21回日本医療薬学会年会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-23790181
[Presentation] がん悪液質のステージ分類に基づくオキシコドンの体内動態および臨床効果の個人差の評価2011
- Author(s)
  内藤隆文, 田代将貴, 山本圭祐, 賀川義之, 川上純一
- Organizer
  第32回日本臨床薬理学会年会
- Place of Presentation
  浜松市
- Year and Date
  2011-12-02
- Data Source
  KAKENHI-PROJECT-21590155
[Presentation] がん悪液質のステージ分類に基づくオキシコドンの体内動態および臨床効果の個人差の評価2011
- Author(s)
  内藤隆文,田代将貴,山本圭祐,賀川義之,川上純一
- Organizer
  第32回日本臨床薬理学会年会
- Place of Presentation
  浜松
- Data Source
  KAKENHI-PROJECT-21590155
[Presentation] Impact of CYP3A5 and ABCB1 gene polymorphisms on plasma disposition of fentanyl and its clinical responses in cancer patients with opioid switching to fentanyl transdermal system.2010
- Author(s)
  Takashina Y, Naito T, Mino Y, Ohnishi K, Kawakami J.
- Organizer
  16th World Congress of Basic and Clinical Pharmacology (WorldPharma2010).
- Place of Presentation
  Copenhagen, Denmark
- Data Source
  KAKENHI-PROJECT-20790132
[Presentation] Impact of CYP2D6and CYP3A5gene polymorphisms on pharmacokinetics of oxycodone and its demethylates and dose escalation rate in cancer patients2010
- Author(s)
  Naito T, Yamamoto K, Takashina Y, Tashiro M, Kagawa Y, Ohnishi K, Kawakami J
- Organizer
  16th World Congress of Basic and Clinical Pharmacology(WorldPharma2010)
- Place of Presentation
  Copenhagen, Denmark
- Data Source
  KAKENHI-PROJECT-21590155
[Presentation] がん性疼痛緩和におけるオピオイド鎮痛薬の体内動態情報に基づく個別化投与量換算法の構築2010
- Author(s)
  内藤隆文
- Organizer
  第20回日本病院薬剤師会東海ブロック学術大会.平成22年度日本薬学会東海支部例会.合同学術大会2010
- Place of Presentation
  静岡
- Data Source
  KAKENHI-PROJECT-20790132
[Presentation] がん患者におけるオキシコドンとその代謝物の血中動態と嘔吐出現-CYP2D6, CYP3A5, ABCB1およびOPRM1の遺伝子変異の影響-2010
- Author(s)
  田代将貴,内藤隆文,山本圭祐,高科嘉章,賀川義之,川上純一
- Organizer
  第130回日本薬学会年会
- Place of Presentation
  岡山
- Data Source
  KAKENHI-PROJECT-21590155
[Presentation] CYP3A5* 3 affects plasma disposition of noroxycodone and dose escalation in cancer patients receiving oxycodone2010
- Author(s)
  Takashina Y, Naito T, Tashiro M, Yamamoto K, Ohnishi K, Kagawa Y, Kawakami J
- Organizer
  第4回次世代を担う若手医療薬科学シンポジウム
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-21590155
[Presentation] CYP3A5*3 affects plasma disposition of noroxycodone and dose escalation in cancer patients receiving oxycodone.2010
- Author(s)
  Takashina Y, Naito T, Tashiro M, Yamamoto K, Ohnishi K, Kagawa Y, Kawakami J.
- Organizer
  第4回次世代を担う医療薬科学シンポジウム
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-20790132
[Presentation] CYP3A5*3 affects plasma disposition of noroxycodone and dose escalation in cancer patients.2010
- Author(s)
  Naito T, Yamamoto K, Takashina Y, Tashiro M, Kagawa Y, Ohnishi K, Kawakami J.
- Organizer
  16th World Congress of Basic and Clinical Pharmacology (WorldPharma2010).
- Place of Presentation
  Copenhagen, Denmark
- Data Source
  KAKENHI-PROJECT-20790132
[Presentation] がん患者におけるオキシコドンとその代謝物の血中動態と嘔吐出現-CYP2D6、CYP3A5、ABCB1およびOPRM1の遺伝子変異の影響-2010
- Author(s)
  内藤隆文, 川上純一, ら
- Organizer
  日本薬学会年会
- Place of Presentation
  岡山コンベンションセンター (岡山)
- Year and Date
  2010-03-28
- Data Source
  KAKENHI-PROJECT-21590155
[Presentation] フェンタニルのマトリックス型貼付剤中残存量の迅速測定法の開発:がん患者における経皮吸収動態の評価への応用2009
- Author(s)
  高科嘉章, 内藤隆文, 八木達也, 山本圭祐, 丸山修治, 兼松直人, 川上純一
- Organizer
  第19回日本医療薬学会年会
- Place of Presentation
  長崎
- Data Source
  KAKENHI-PROJECT-20790132
[Presentation] がん患者におけるフェンタニルのマトリックス型とリザーバー型貼付剤間の経皮吸収および血中動態の比較2009
- Author(s)
  高科嘉章, 内藤隆文, 八木達也, 山本圭祐, 山田尚広, 田中紀章, 門口直仁, 平野公美, 丸山修治, 川上純一
- Organizer
  日本病院薬剤師会東海ブロック・日本薬学会東海支部合同学術大会2009
- Place of Presentation
  四日市
- Data Source
  KAKENHI-PROJECT-20790132
[Presentation] がん患者におけるオキシコドンの有害作用と耐性形成に及ぼすCYP3A5, CYP2D6およびOPRM1の遺伝子変異の影響2009
- Author(s)
  山本圭祐,内藤隆文,高科嘉章,丸山修治,賀川義之,川上純一
- Organizer
  第30回日本臨床薬理学会年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-21590155
[Presentation] がん患者におけるオキシコドンの有害作用と耐性形成に及ぼすCYP3A5, CYP2D6およびOPRM1の遺伝子変異の影響2009
- Author(s)
  山本圭祐, 内藤隆文, 高科嘉章, 丸山修治, 賀川義之, 川上純一
- Organizer
  第30回日本臨床薬理学会年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-20790132
[Presentation] がん患者におけるオキシコドンの有害作用と耐性形成に及ぼすCYP3A5、CYP2D6およびOPRM1の遺伝子変異の影響2009
- Author(s)
  内藤隆文、川上純一, ら
- Organizer
  日本臨床薬理学会年会
- Place of Presentation
  パシフィコ横浜(横浜)
- Year and Date
  2009-12-03
- Data Source
  KAKENHI-PROJECT-20790132

1. KAWAKAMI Junichi (50272539)

# of Collaborated Projects: 9 results

# of Collaborated Products: 21 results
2. YAGI Tatsuya (70719575)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
3. TANAKA Hironari

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
4. ISHIDA Takuya

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
5. Magata Yasuhiro (20209399)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 鈴木千恵 (20637285)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 中村和正 (20284507)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 志田拓顕 (40857322)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 柴田海斗 (00857055)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. TASHIRO Masaki

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
11. SATO Hikaru

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
12. 大西一功

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Naito Takafumi 内藤 隆文

NAITO Takafumi 内藤 隆文

Research Projects

Research Products

Co-Researchers

脳血管障害時におけるAMPA受容体拮抗薬の中枢移行および薬効・有害作用の個人差の解明

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Investigation of interindividual variability in pharmacokinetics of and clinical responses to orexin receptor antagonists in cancer statusPrincipal Investigator

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Investigation of interindividual factors determining the clinical effects of peripherally-acting mu-opioid receptor antagonist under cancer conditions

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Kinetic analyses of thyroid hormone based on hepatic uptake transporter activity during the perinatal periodPrincipal Investigator

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Elucidation of Pathological function of central dysfunction in cancer cachexia by imaging science

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Investigation of interindividual variability in pharmacokinetics of and clinical responses to neuropathic pain medications in cancer patients

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Prediction of opioid analgesics pharmacokinetics using the biomarkers of drug metabolizing enzyme activity in cancer patientsPrincipal Investigator

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Prediction of interindividual variations in pain relief and adverse effects of opioid analgesics based on cancer disease stage

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Investigation of interindividual factors determining the pain relief and adverse effects of opioid analgesics in cancer cachexiaPrincipal Investigator

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Investigation of interindividual variability in pharmacokinetics of and clinical responses to analgesics for cancer pain relief

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Investigation of relationship between the pharmacokinetics of and clinical responses to prochlorperazine in patients receiving opioidsPrincipal Investigator

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Investigation of interindividual variability in pharmacokinetics of and clinical responses to opioid analgesics in cancer pain patients

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Establishment of optimal conversion ratios of opioid analgesics based on genetic polymorphisms in individual palliative carePrincipal Investigator

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Naito Takafumi 内藤隆文

NAITO Takafumi 内藤隆文