Sakae Nobutaka 栄信孝

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SAKAE Nobutaka 栄信孝

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Researcher Number	80423523
Affiliation (Current)	2025: 独立行政法人国立病院機構大牟田病院(臨床研究部), 脳神経内科, 医長
Affiliation (based on the past Project Information) *help	2009 – 2013: Kyushu University, 大学病院, 助教 2010: Kyushu University, 医学研究院, 神経内科 2010: 九州大学, 病院神経内科, 助教
Review Section/Research Field	Principal Investigator Neurology Except Principal Investigator Neurology / Radiation science
Keywords	Principal Investigator 神経病理学 / 神経化学 / ユビキチン・プロテアソーム / 細胞内輸送機能異常 / 脳神経疾患 / ゴルジ体 / 細胞内輸送機能 / モデルマウス / ポリグルタミン病 / 脊髄小脳変性症 / 神経分子病態学 … More Except Principal Investigator … More ミオパチー / 拡散 / テンソル / 骨格筋 / Muscle / DTI / DWI / MRI / p53 / モリス水迷路 / 酸化ストレス / リン酸化タウ蛋白 / 小胞体ストレス / 毒性ターン / インスリン分解酵素 / インスリン抵抗性 / アミロイドβ / アポモルフィン / モデルマウス / アルツハイマー病 / 神経分子病態学 / 変異SOD1遺伝子導入マウス / G-CSF / ALS Less

Development of apomorphine therapy for Alzheimer disease
- Principal Investigator
  
  OHYAGI Yasumasa
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Kyushu University
Evaluation of neuromuscular disease activity by diffusion tensor imaging
- Principal Investigator
  
  HATAKENAKA Masamitsu
- Project Period (FY)
  2010 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Radiation science
- Research Institution
  Sapporo Medical University
  Kyushu University
ALSに対するG-CSFの運動ニューロン保護作用の解明と髄腔内持続投与療法の開発
- Principal Investigator
  
  山崎亮
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Kyushu University
The study of the molecular mechanism of polyglutamine disease model mice and search for new therapeutic moleculePrincipal Investigator
- Principal Investigator
  
  SAKAE Nobutaka
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Neurology
- Research Institution
  Kyushu University

All 2013 2011 2010 2009

All Journal Article Presentation

[Journal Article] Intracellular accumulation of toxic turn amyloid-β is associated with endoplasmic reticulum stress in Alzheimer's disease.2013
- Author(s)
  Soejima N, Ohyagi Y, Nakamura N, Himeno E, Iinuma KM, Sakae N, Yamasaki R, Tabira T, Murakami K, Irie K, Kinoshita N, LaFerla FM, Kiyohara Y, Iwaki T, Kira J
- Journal Title
  
  CurrAlzheimer Res
  
  Volume: 10 Issue: 1 Pages: 11-20
- DOI
  10.2174/1567205011310010003
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590936, KAKENHI-PROJECT-23890150
[Journal Article] Apomorphine treatment in Alzheimer mice promoting amyloid-β degradation.2011
- Author(s)
  Himeno E, Ohyagi Y, Ma L, Nakamura N, Miyoshi K, Sakae N, Motomura K, Soejima N, Yamasaki R, Hashimoto T, Tabira T, LaFerla FM, Kira J.Ann Neurol
- Journal Title
  
  69(2)
  
  Pages: 248-256
- Data Source
  KAKENHI-PROJECT-21790845
[Journal Article] Apomorphin treatment in Alzheimer mice promoting amyroid-b degradation2011
- Author(s)
  Himeno E, Ohyagi Y, Ma L, Nakamura N, Miyoshi K, Sakae N, et al
- Journal Title
  
  Annals of Neurology
  
  Volume: 69(2) Pages: 248-256
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790845
[Journal Article] Activation of glutathione peroxidase and inhibition of p53-related apoptosis by apomorphine.2011
- Author(s)
  Ma L, Ohyagi Y, Nakamura N, Iinuma KM, Miyoshi K, Himeno E, Soejima N, Yanagihara YT, Sakae N, Yamasaki R, Kira J
- Journal Title
  
  J Alzheimers Dis
  
  Volume: 27 Issue: 1 Pages: 225-237
- DOI
  10.3233/jad-2011-110140
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590936, KAKENHI-PROJECT-23890150
[Journal Article] Apomorphine treatment in Alzheimer mice promoting amyloid-β degradation.2011
- Author(s)
  Himeno E, Ohyagi Y, Ma L, Nakamura N, Miyoshi K, Sakae N, Motomura K, Soejima N, Yamasaki R, Hashimoto T, Tabira T, LaFerla FM, Kira J
- Journal Title
  
  Ann Neurol
  
  Volume: 69 Issue: 2 Pages: 248-256
- DOI
  10.1002/ana.22319
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590936, KAKENHI-PROJECT-23890150
[Journal Article] Alcohol drinking and risk of Parkinson's disease: a case-control study in Japan.2010
- Author(s)
  Fukushima W, Miyake Y, Tanaka K, Sasaki S, Kiyohara C, Tsuboi Y, Yamada T, Oeda T, Miki T, Kawamura N, Sakae N, Fukuyama H, Hirota Y, Nagai M
- Journal Title
  
  Fukuoka Kinki Parkinson's Disease Study Group.BMC Neurol. Nov 5;10:111.
- Data Source
  KAKENHI-PROJECT-21790845
[Journal Article] Case-control study of risk of Parkinson's disease in relation to hypertension, hypercholesterolemia, and diabetes in Japan.2010
- Author(s)
  Miyake Y, Tanaka K, Fukushima W, Sasaki S, kiyohara C, Tsuboi Y, Sakae N, et al
- Journal Title
  
  J Neurol Sci
  
  Volume: 293 Pages: 82-86
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790845
[Journal Article] Phenotypic spectrum of hereditary neuralgic amyotrophy caused by the SEPT9 R88W mutation.2010
- Author(s)
  Ueda M, Kawamura N, Tateishi T, Sakae N, Motomura K, Ohyagi Y, Kira JI.
- Journal Title
  
  J Neurol Neurosurg Psychiatry. Jan;81(1)
  
  Pages: 94-96
- Data Source
  KAKENHI-PROJECT-21790845
[Journal Article] Enhancement of activation of caspases by presenilin 1 gene mutations and its inhibition by secretase inhibitors.2009
- Author(s)
  Miyoshi K, Ohyagi Y, Sakae N, Motomura K, Ma L, et al
- Journal Title
  
  J Alzheimers Dis. 16
  
  Pages: 551-564
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790845
[Journal Article] Phenotypic spectrum of hereditary neuralgic amyotrophy caused by the SEPT9R88W mutation2009
- Author(s)
  Ueda M, Kawamura N, Tateishi T, Sakae N, Motomura K, Ohyaei Y, et al
- Journal Title
  
  J Neurol Neurosurg Psychiatry 81
  
  Pages: 94-96
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790845
[Journal Article] Increase in p53 protein levels by presenilin 1 gene mutations and its inhibition by secretase inhibitors.2009
- Author(s)
  Ma L, Ohyagi Y, Miyoshi K, Sakae N, et al
- Journal Title
  
  J Alzheimers Dis. 16
  
  Pages: 565-575
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790845
[Presentation] 運動失調症の病態機序における細胞内輸送機能の検討2010
- Author(s)
  栄信孝、他
- Organizer
  第51回日本神経学会総会
- Place of Presentation
  東京
- Year and Date
  2010-05-20
- Data Source
  KAKENHI-PROJECT-21790845
[Presentation] Analysis of the MJD/SCA3 Tg mice from the view of neuronal dysfunction2010
- Author(s)
  栄信孝
- Organizer
  Society for Neuroscience 40th Annual Meeting 2010
- Place of Presentation
  San Diego(米国)
- Year and Date
  2010-11-14
- Data Source
  KAKENHI-PROJECT-21790845
[Presentation] 運動失調症における細胞内輸送機能の検討2010
- Author(s)
  栄信孝
- Organizer
  日本神経学会総会
- Place of Presentation
  東京国際フォーラム(東京都)
- Year and Date
  2010-05-21
- Data Source
  KAKENHI-PROJECT-21790845
[Presentation] Machado-Joseph 病(MJD)における細胞内輸送機能の検討2009
- Author(s)
  栄信孝、他
- Organizer
  第50回日本神経学会総会
- Place of Presentation
  仙台
- Year and Date
  2009-05-21
- Data Source
  KAKENHI-PROJECT-21790845
[Presentation] A study of the mechanism of spinocerebellar ataxia from the view of neuronal dysfunction2009
- Author(s)
  Sakae N, et, al.
- Organizer
  39th Annual Meetings of Society for Neurosciences
- Place of Presentation
  Chicago USA
- Year and Date
  2009-10-03
- Data Source
  KAKENHI-PROJECT-21790845
[Presentation] 運動失調症における細胞内輸送機能検討2009
- Author(s)
  栄信孝、大八木保政、吉良潤一
- Organizer
  日本神経学会総会
- Place of Presentation
  仙台
- Year and Date
  2009-05-20
- Data Source
  KAKENHI-PROJECT-21790845
[Presentation] A study of the mechanism of spinocerebellar ataxia from the view of neuronal dysfunction2009
- Author(s)
  栄信孝、大八木保政、吉良潤一
- Organizer
  39^<th> Neuroscience meeting
- Place of Presentation
  Chicago
- Year and Date
  2009-10-17
- Data Source
  KAKENHI-PROJECT-21790845

1. OHYAGI Yasumasa (30301336)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
2. MOTOMURA Kyoko (20380644)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
3. NAKABEPPU Yusaku (30180350)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. HATAKENAKA Masamitsu (40253413)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. TAKASHIMA Hiroyuki (90608738)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. TMATSUO Yoshio (50419595)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. NISHIKAWA Kei (30380447)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. HONDA Hiroshi (90145433)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. SUNAMI Shunya (80532845)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. KAMITANI Takeshi (20419534)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 山崎亮 (10467946)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 立石貴久 (50423546)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Sakae Nobutaka 栄 信孝

SAKAE Nobutaka 栄 信孝

Research Projects

Research Products

Co-Researchers

Development of apomorphine therapy for Alzheimer disease

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Evaluation of neuromuscular disease activity by diffusion tensor imaging

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

ALSに対するG-CSFの運動ニューロン保護作用の解明と髄腔内持続投与療法の開発

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The study of the molecular mechanism of polyglutamine disease model mice and search for new therapeutic moleculePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Intracellular accumulation of toxic turn amyloid-β is associated with endoplasmic reticulum stress in Alzheimer's disease.2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Apomorphine treatment in Alzheimer mice promoting amyloid-β degradation.2011

Author(s)

Journal Title

Data Source

[Journal Article] Apomorphin treatment in Alzheimer mice promoting amyroid-b degradation2011

Author(s)

Journal Title

Data Source

[Journal Article] Activation of glutathione peroxidase and inhibition of p53-related apoptosis by apomorphine.2011

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Apomorphine treatment in Alzheimer mice promoting amyloid-β degradation.2011

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Alcohol drinking and risk of Parkinson's disease: a case-control study in Japan.2010

Author(s)

Journal Title

Data Source

[Journal Article] Case-control study of risk of Parkinson's disease in relation to hypertension, hypercholesterolemia, and diabetes in Japan.2010

Author(s)

Journal Title

Data Source

[Journal Article] Phenotypic spectrum of hereditary neuralgic amyotrophy caused by the SEPT9 R88W mutation.2010

Author(s)

Journal Title

Data Source

[Journal Article] Enhancement of activation of caspases by presenilin 1 gene mutations and its inhibition by secretase inhibitors.2009

Author(s)

Journal Title

Data Source

[Journal Article] Phenotypic spectrum of hereditary neuralgic amyotrophy caused by the SEPT9R88W mutation2009

Author(s)

Journal Title

Data Source

[Journal Article] Increase in p53 protein levels by presenilin 1 gene mutations and its inhibition by secretase inhibitors.2009

Author(s)

Journal Title

Data Source

[Presentation] 運動失調症の病態機序における細胞内輸送機能の検討2010

Author(s)

Organizer

Place of Presentation

Sakae Nobutaka 栄信孝

SAKAE Nobutaka 栄信孝