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Hirakawa Hidetada  平川 秀忠

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… Alternative Names

HIRAKAWA Hidetada  平川 秀忠

平川 秀忠  ヒラカワ ヒデタダ

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Researcher Number 80431758
Other IDs
Affiliation (Current) 2025: 群馬大学, 大学院医学系研究科, 准教授
Affiliation (based on the past Project Information) *help 2020 – 2024: 群馬大学, 大学院医学系研究科, 准教授
2017 – 2019: 群馬大学, 大学院医学系研究科, 講師
2012 – 2014: 群馬大学, 先端科学研究指導者育成ユニット, 助教
2013: 群馬大学, その他部局等, 助教
2006: 千葉大学, 大学院薬学研究科, 助手
Review Section/Research Field
Principal Investigator
Basic Section 49050:Bacteriology-related / Bacteriology (including Mycology) / Medium-sized Section 58:Society medicine, nursing, and related fields / Biological pharmacy / Applied microbiology
Keywords
Principal Investigator
病原性 / 薬剤耐性 / 発現制御 / 感染症 / バイオフィルム / 尿路感染症 / 情報伝達 / 感染制御 / 環境応答 / アンチセンスRNA … More / シグナル伝達 / 細菌 / 毒素 / 腎盂腎炎 / 抗菌薬 / 環境 / 抗生物質 / 運動性 / ホモセリンラクトン / オートインデューサー / アンチセンスRNA / クオラムセンシング / Homerine lactone / Quorum Sensing / 微生物 Less
  • Research Projects

    (7 results)
  • Research Products

    (45 results)
  • Co-Researchers

    (4 People)
  •  マクロ孔をもつ多孔質炭素を利用した多種腸管感染症の重症化予防、治療技術の基盤構築Principal Investigator

    • Principal Investigator
      平川 秀忠
    • Project Period (FY)
      2024 – 2026
    • Research Category
      Grant-in-Aid for Challenging Research (Exploratory)
    • Review Section
      Medium-sized Section 58:Society medicine, nursing, and related fields
    • Research Institution
      Gunma University
  •  細菌由来リスク因子に着目した尿路病原性大腸菌による腎盂腎炎発症と難治化機構の解明Principal Investigator

    • Principal Investigator
      平川 秀忠
    • Project Period (FY)
      2022 – 2025
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 49050:Bacteriology-related
    • Research Institution
      Gunma University
  •  Mechanism of environmental response and micro-colony induction in uropathogenic E. coliPrincipal Investigator

    • Principal Investigator
      Hirakawa Hidetada
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 49050:Bacteriology-related
    • Research Institution
      Gunma University
  •  Mechanism of virulence induction under iron-restricted conditions in uropathogenic Escherichia coliPrincipal Investigator

    • Principal Investigator
      Hirakawa Hidetada
    • Project Period (FY)
      2017 – 2018
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Biological pharmacy
    • Research Institution
      Gunma University
  •  Functional analysis of anti-sense RNA and signal transduction in bacteriaPrincipal Investigator

    • Principal Investigator
      HIRAKAWA Hidetada
    • Project Period (FY)
      2013 – 2014
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Applied microbiology
    • Research Institution
      Gunma University
  •  クオラムセンシング新規制御因子アンチセンスリボ核酸の機能解明Principal Investigator

    • Principal Investigator
      平川 秀忠
    • Project Period (FY)
      2012 – 2013
    • Research Category
      Grant-in-Aid for Research Activity Start-up
    • Research Field
      Bacteriology (including Mycology)
    • Research Institution
      Gunma University
  •  肺炎球菌の病原性発現の分子機構Principal Investigator

    • Principal Investigator
      平川 秀忠
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Young Scientists (Start-up)
    • Research Field
      Bacteriology (including Mycology)
    • Research Institution
      Chiba University

All 2023 2022 2021 2020 2019 2018 2017 2015 2014 2013 2012 Other

All Journal Article Presentation Book

  • [Book] 実験医学2013

    • Author(s)
      平川秀忠:
    • Total Pages
      2
    • Publisher
      羊土社
    • Data Source
      KAKENHI-PROJECT-25870115
  • [Book] 日本細菌学会誌2013

    • Author(s)
      平川秀忠、富田治芳
    • Total Pages
      11
    • Publisher
      日本細菌学会
    • Data Source
      KAKENHI-PROJECT-25870115
  • [Journal Article] Inactivation of ackA and pta Genes Reduces GlpT Expression and Susceptibility to Fosfomycin in Escherichia coli.2023

    • Author(s)
      Hirakawa H, Takita A, Sato Y, Hiramoto S, Hashimoto Y, Ohshima N, Minamishima YA, Murakami M, Tomita H.
    • Journal Title

      Microbiol Spectr.

      Volume: 11 Issue: 3 Pages: 1-15

    • DOI

      10.1128/spectrum.05069-22

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-22K07067, KAKENHI-PROJECT-23K24126, KAKENHI-PROJECT-23K24226
  • [Journal Article] The PapB/FocB family protein TosR acts as a positive regulator of flagellar expression and is required for optimal virulence of uropathogenic Escherichia coli.2023

    • Author(s)
      Hirakawa H, Shimokawa M, Noguchi K, Tago M, Matsuda H, Takita A, Suzue K, Tajima H, Kawagishi I, Tomita H.
    • Journal Title

      Front Microbiol.

      Volume: 14 Pages: 1185804-1185804

    • DOI

      10.3389/fmicb.2023.1185804

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-22K07067, KAKENHI-PROJECT-23K24126
  • [Journal Article] A Macroporous Magnesium Oxide-Templated Carbon Adsorbs Shiga Toxins and Type III Secretory Proteins in Enterohemorrhagic Escherichia coli, Which Attenuates Virulence2022

    • Author(s)
      Hirakawa Hidetada、Suzue Kazutomo、Uchida Motoyuki、Takita Ayako、Kamitani Wataru、Tomita Haruyoshi
    • Journal Title

      Frontiers in Microbiology

      Volume: 13 Pages: 883689-883689

    • DOI

      10.3389/fmicb.2022.883689

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-23K24126
  • [Journal Article] Elucidation of host diversity of the VanD-carrying genomic islands in enterococci and anaerobes2022

    • Author(s)
      Hashimoto Yusuke、Hisatsune Junzo、Suzuki Masato、Kurushima Jun、Nomura Takahiro、Hirakawa Hidetada、Kojima Naoko、Ono Yuichi、Hasegawa Yutaka、Tanimoto Koichi、Sugai Motoyuki、Tomita Haruyoshi
    • Journal Title

      JAC-Antimicrobial Resistance

      Volume: 4 Issue: 1 Pages: 189-189

    • DOI

      10.1093/jacamr/dlab189

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K07533, KAKENHI-PROJECT-19K17922, KAKENHI-PROJECT-20K07509
  • [Journal Article] Roles of the Tol/Pal System in Bacterial Pathogenesis and Its Application to Antibacterial Therapy2022

    • Author(s)
      Hirakawa Hidetada、Suzue Kazutomo、Tomita Haruyoshi
    • Journal Title

      Vaccines

      Volume: 10 Issue: 3 Pages: 422-422

    • DOI

      10.3390/vaccines10030422

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K07533
  • [Journal Article] Adsorption of extracellular proteases and pyocyanin produced by Pseudomonas aeruginosa using a macroporous magnesium oxide-templated carbon decreases cytotoxicity2022

    • Author(s)
      Hirakawa Hidetada、Kimura Ayuko、Takita Ayako、Chihara Sayaka、Tanimoto Koichi、Tomita Haruyoshi
    • Journal Title

      Current Research in Microbial Sciences

      Volume: 3 Pages: 100160-100160

    • DOI

      10.1016/j.crmicr.2022.100160

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-23K24126
  • [Journal Article] Roles of OmpX, an outer membrane protein on virulence and flagellar expression in uropathogenic Escherichia coli2021

    • Author(s)
      Hirakawa Hidetada、Suzue Kazutomo、Takita Ayako、Kamitani Wataru、Tomita Haruyoshi
    • Journal Title

      Infection and Immunity

      Volume: 89 Issue: 6

    • DOI

      10.1128/iai.00721-20

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19K07533
  • [Journal Article] Adsorption of Phenazines Produced by Pseudomonas aeruginosa Using AST-120 Decreases Pyocyanin-Associated Cytotoxicity2021

    • Author(s)
      Hirakawa Hidetada、Takita Ayako、Uchida Motoyuki、Kaneko Yuka、Kakishima Yuto、Tanimoto Koichi、Kamitani Wataru、Tomita Haruyoshi
    • Journal Title

      Antibiotics

      Volume: 10 Issue: 4 Pages: 434-434

    • DOI

      10.3390/antibiotics10040434

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K07533
  • [Journal Article] cAMP Receptor Protein Positively Regulates the Expression of Genes Involved in the Biosynthesis of Klebsiella oxytoca Tilivalline Cytotoxin2021

    • Author(s)
      Rodr?guez-Valverde Diana、Le?n-Montes Nancy、Soria-Bustos Jorge、Mart?nez-Cruz Jessica、Gonz?lez-Ugalde Ricardo、Rivera-Guti?rrez Sandra、Gonz?lez-y-Merchand Jorge A.、Rosales-Reyes Roberto、Garc?a-Morales L?zaro、Hirakawa Hidetada、Fox James G.、Gir?n Jorge A.、De la Cruz Miguel A.、Ares Miguel A.
    • Journal Title

      Frontiers in Microbiology

      Volume: 12 Pages: 743594-743594

    • DOI

      10.3389/fmicb.2021.743594

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K07533
  • [Journal Article] Roles of OmpA in Type III Secretion System-Mediated Virulence of Enterohemorrhagic Escherichia coli2021

    • Author(s)
      Hirakawa Hidetada、Suzue Kazutomo、Takita Ayako、Tomita Haruyoshi
    • Journal Title

      Pathogens

      Volume: 10 Issue: 11 Pages: 1496-1496

    • DOI

      10.3390/pathogens10111496

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K07533
  • [Journal Article] Roles of CytR, an anti-activator of cyclic-AMP receptor protein (CRP) on flagellar expression and virulence in uropathogenic Escherichia coli2020

    • Author(s)
      Hirakawa Hidetada、Takita Ayako、Kato Mao、Mizumoto Hanano、Tomita Haruyoshi
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 521 Issue: 3 Pages: 555-561

    • DOI

      10.1016/j.bbrc.2019.10.165

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19K07533
  • [Journal Article] Roles of the Tol-Pal system in the Type III secretion system and flagella-mediated virulence in enterohemorrhagic Escherichia coli2020

    • Author(s)
      Hirakawa Hidetada、Suzue Kazutomo、Takita Ayako、Awazu Chikako、Kurushima Jun、Tomita Haruyoshi
    • Journal Title

      Scientific Reports

      Volume: 10 Issue: 1 Pages: 15173-15173

    • DOI

      10.1038/s41598-020-72412-w

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K07533
  • [Journal Article] Progress Overview of Bacterial Two-Component Regulatory Systems as Potential Targets for Antimicrobial Chemotherapy2020

    • Author(s)
      Hirakawa Hidetada、Kurushima Jun、Hashimoto Yusuke、Tomita Haruyoshi
    • Journal Title

      Antibiotics

      Volume: 9 Issue: 10 Pages: 635-635

    • DOI

      10.3390/antibiotics9100635

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K07533
  • [Journal Article] Cooperative Actions of CRP-cAMP and FNR Increase the Fosfomycin Susceptibility of Enterohaemorrhagic Escherichia coli (EHEC) by Elevating the Expression of glpT and uhpT under Anaerobic Conditions2017

    • Author(s)
      Kurabayashi Kumiko、Tanimoto Koichi、Tomita Haruyoshi、Hirakawa Hidetada
    • Journal Title

      Frontiers in Microbiology

      Volume: 8 Pages: 426-426

    • DOI

      10.3389/fmicb.2017.00426

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K17631
  • [Journal Article] Identification of a second two-component signal transduction system that controls fosfomycin tolerance and glycerol-3-phosphate uptake.2015

    • Author(s)
      1.Kurabayashi K. Hirakawa Y, Tanimoto K, Tomita H, Hirakawa H
    • Journal Title

      Journal of Bacteriology

      Volume: 197 Issue: 5 Pages: 861-871

    • DOI

      10.1128/jb.02491-14

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-25870115
  • [Journal Article] The role of the CpxAR two-component signal transduction system in control of fosfomycin resistance and carbon substrate uptake2014

    • Author(s)
      Kurabayashi K. Hirakawa Y, Tanimoto K, Tomita H, Hirakawa H
    • Journal Title

      Journal of Bacteriology

      Volume: 196 Issue: 2 Pages: 248-256

    • DOI

      10.1128/jb.01151-13

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-25870115
  • [Journal Article] 新しい細菌オートインデューサーによるクオラムセンシング機構2014

    • Author(s)
      平川秀忠、富田治芳
    • Journal Title

      感染・免疫・炎症

      Volume: 44 Pages: 269-272

    • Data Source
      KAKENHI-PROJECT-25870115
  • [Journal Article] Interference of bacterial cell-to-cell communication: a new concept of antimicrobial chemotherapy breaks antibiotic resistance2013

    • Author(s)
      Hirakawa H, Tomita H
    • Journal Title

      Frontiers in Microbiology

      Volume: 4-114 Pages: 1-14

    • DOI

      10.3389/fmicb.2013.00114

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25870115
  • [Journal Article] Antisense RNA that affects Rhodopseudomonas palustris quorum-sensing signal receptor expression2012

    • Author(s)
      Hirakawa H
    • Journal Title

      Proceedings of National Academy of Sciences of the United States of America

      Volume: 109 Pages: 12141-12146

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24890033
  • [Presentation] Uropathogenic Escherichia Coli; Virulence and Pathogenesis2023

    • Author(s)
      Hidetada Hirakawa
    • Organizer
      19th Asia Pacific Congress of Clinical Microbiology and Infection (APCCMI2023)
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-23K24126
  • [Presentation] Microcolony formation and pathogenicity of uropathogenic Escherichia coli (UPEC) in host cells2023

    • Author(s)
      Hidetada Hirakawa
    • Organizer
      日本バイオフィルム学会第37回学術集会
    • Invited
    • Data Source
      KAKENHI-PROJECT-23K24126
  • [Presentation] 抗感染症薬としての吸着剤の可能性2023

    • Author(s)
      平川秀忠
    • Organizer
      第96回日本細菌学会総会
    • Invited
    • Data Source
      KAKENHI-PROJECT-23K24126
  • [Presentation] ROLES OF THE TOL/PAL SYSTEM ON THE PRODUCTION OF FLAGELLAR AND THE TYPE III SECRETION SYSTEM MACHINERY2021

    • Author(s)
      Hidetada Hirakawa
    • Organizer
      BACTERIAL LOCOMOTION AND SIGNAL TRANSDUCTION - BLAST
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K07533
  • [Presentation] マクロ孔吸着炭を利用した腸管出血性大腸菌の志賀毒素と3型分泌蛋白質の吸着および、病原性抑制2021

    • Author(s)
      平川秀忠、富田治芳
    • Organizer
      第68回日本化学療法学会東日本支部総会
    • Data Source
      KAKENHI-PROJECT-19K07533
  • [Presentation] 腸管出血性大腸菌(EHEC) O157の腸管病原性におけるTol/Palシステムの役割2020

    • Author(s)
      平川秀忠
    • Organizer
      第103回日本細菌学会関東支部総会 2020年10月
    • Data Source
      KAKENHI-PROJECT-19K07533
  • [Presentation] 腸管出血性大腸菌の病原性におけるTol-Palシステムの役割2020

    • Author(s)
      平川秀忠
    • Organizer
      第67回日本化学療法学会東日本支部総会
    • Data Source
      KAKENHI-PROJECT-19K07533
  • [Presentation] 腸管出血性大腸菌 (EHEC)の病原性因子Tol/Palシステムの解析2020

    • Author(s)
      平川秀忠
    • Organizer
      第34回日本バイオフィルム学会学術集会
    • Data Source
      KAKENHI-PROJECT-19K07533
  • [Presentation] 尿路病原性大腸菌(UPEC)のマイクロコロニー形成と鞭毛発現抑制因子CytRの解析2019

    • Author(s)
      平川秀忠、富田治芳
    • Organizer
      第92回日本細菌学会総会
    • Data Source
      KAKENHI-PROJECT-19K07533
  • [Presentation] 細胞外シチジンによる尿路病原性大腸菌のマイクロコロニー形成と鞭毛遺伝子発現誘導機構の解析2019

    • Author(s)
      平川秀忠、滝田綾子、富田治芳
    • Organizer
      第102回日本細菌学会関東支部総会
    • Data Source
      KAKENHI-PROJECT-19K07533
  • [Presentation] バイオフィルムを標的とした薬剤耐性大腸菌感染症に対する新たな治療戦略 創出のためのアプローチ2019

    • Author(s)
      平川秀忠、富田治芳
    • Organizer
      第93回日本感染症学会総会・学術講演会
    • Invited
    • Data Source
      KAKENHI-PROJECT-19K07533
  • [Presentation] 尿路病原性大腸菌(UPEC)の膀胱上皮細胞内におけるIBC形成機構2018

    • Author(s)
      平川秀忠、富田治芳
    • Organizer
      第30回微生物シンポジウム
    • Invited
    • Data Source
      KAKENHI-PROJECT-17K17631
  • [Presentation] TolB, the Periplasmic Protein That Controls Flagellar Biosynthesis and the Biofilm Formation in Uropathogenic Escherichia coli (UPEC)2018

    • Author(s)
      Hidetada Hirakawa, Haruyoshi Tomita
    • Organizer
      ASM conference on Biofilms
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K17631
  • [Presentation] 尿路病原性大腸菌(UPEC)のマイクロコロニー形成と鞭毛形成因子TolBの機能解析2018

    • Author(s)
      平川秀忠、富田治芳
    • Organizer
      第101回日本細菌学会関東支部総会
    • Data Source
      KAKENHI-PROJECT-17K17631
  • [Presentation] 尿路病原性大腸菌のマイクロコロニー形成におけるTolBの機能2017

    • Author(s)
      平川秀忠、倉林久美子、富田治芳
    • Organizer
      第100回日本細菌学会関東支部総会
    • Data Source
      KAKENHI-PROJECT-17K17631
  • [Presentation] The tolB gene which encodes the periplasmic protein contributes to the formation of intracellular bacterial communities (IBCs) in uropathogenic Escherichia coli (UPEC)2017

    • Author(s)
      Hidetada Hirakawa, Kumiko Kurabayshi and Haruyoshi Tomita
    • Organizer
      6th ASM conference on cell-cell communication inbacteria
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K17631
  • [Presentation] 尿路病原性大腸菌(UPEC)の膀胱上皮細胞感染におけるTolBの機能2017

    • Author(s)
      平川秀忠、倉林久美子、富田治芳
    • Organizer
      第64回日本化学療法学会東日本支部総会
    • Data Source
      KAKENHI-PROJECT-17K17631
  • [Presentation] 尿路病原性大腸菌(Uropathogenic E. coli: UPEC)の鉄欠乏応答と膀胱上皮細胞内におけるバイオフィルム形成2017

    • Author(s)
      平川秀忠
    • Organizer
      第90回日本細菌学会総会
    • Invited
    • Data Source
      KAKENHI-PROJECT-17K17631
  • [Presentation] アシルホモセリンラクトン新規サブタイプと細菌間コミュニケーション2013

    • Author(s)
      平川秀忠
    • Organizer
      日本細菌学会 第7回若手研究者育成のためのワークショップ 若手研究者によるバイオフィルム研究ワークショップ
    • Place of Presentation
      国立感染症研究所
    • Invited
    • Data Source
      KAKENHI-PROJECT-25870115
  • [Presentation] Quorum sensing in a photosynthetic soil bacterium and its regulatory element, Anti-sense RNA2013

    • Author(s)
      平川 秀忠
    • Organizer
      第86回日本細菌学会総会
    • Place of Presentation
      千葉
    • Data Source
      KAKENHI-PROJECT-24890033
  • [Presentation] Quorum sensingの新規抑制因子Non-coding regulatory anti-sense RNA2012

    • Author(s)
      平川 秀忠
    • Organizer
      第95回日本細菌学会関東支部会
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-24890033
  • [Presentation] Reversible Control of Fosfomycin Resistance and Carbon Substrate Uptake by Two-component Signal Transduction System

    • Author(s)
      Kumiko Kurabayashi, Yuko Hirakawa, Koichi Tanimoto, Haruyoshi Tomita, Hidetada Hirakawa
    • Organizer
      American Society for Microbiology 114th General Meeting
    • Place of Presentation
      ボストン
    • Year and Date
      2014-05-17 – 2014-05-20
    • Data Source
      KAKENHI-PROJECT-25870115
  • [Presentation] Trimethylamine-N-oxide感知応答Torシステムによる腸管出血性大腸菌O157のホスホマイシン耐性誘導

    • Author(s)
      倉林久美子、平川裕子、谷本弘一、富田治芳、平川秀忠
    • Organizer
      第61回日本化学療法学会東日本支部総会
    • Place of Presentation
      東京
    • Year and Date
      2014-10-29 – 2014-10-31
    • Data Source
      KAKENHI-PROJECT-25870115
  • [Presentation] 社会形成による大腸菌群の薬剤耐性と病原性制御

    • Author(s)
      平川秀忠
    • Organizer
      第66回日本生物工学会大会
    • Place of Presentation
      札幌
    • Year and Date
      2014-09-09 – 2014-09-11
    • Invited
    • Data Source
      KAKENHI-PROJECT-25870115
  • 1.  鈴江 一友 (00333485)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 1 results
  • 2.  木村 鮎子 (50553616)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 1 results
  • 3.  村上 正巳 (30241871)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 4.  富田 治芳
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results

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