Goyama Susumu 合山進

… Alternative Names

GOYAMA Susumu 合山進

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Researcher Number	80431849
Other IDs	https://orcid.org/0000-0002-9339-1826
Affiliation (Current)	2024: 東京大学, 大学院新領域創成科学研究科, 教授
Affiliation (based on the past Project Information) *help	2020 – 2024: 東京大学, 大学院新領域創成科学研究科, 教授 2020: 東京大学, 新領域創成科学研究科, 教授 2015 – 2020: 東京大学, 医科学研究所, 准教授 2017: 東京大学, 医学部附属病院, 助教 2009: The University of Tokyo, 医学部附属病院, 助教 … More 2008 – 2009: The University of Tokyo, 医学部・附属病院, 助教 2007: The University of Tokyo, 医学部・附属病院, 医員 2006: The University of Tokyo, Faculty of Medicine, Research Associate, 医学部附属病院, 医員 Less
Review Section/Research Field	Principal Investigator Hematology / Medium-sized Section 54:Internal medicine of the bio-information integration and related fields / Basic Section 54010:Hematology and medical oncology-related / Complex systems / Medium-sized Section 50:Oncology and related fields Except Principal Investigator Basic Section 54010:Hematology and medical oncology-related / Medium-sized Section 54:Internal medicine of the bio-information integration and related fields / Internal medicine of the bio-information integration and related fields / Hematology
Keywords	Principal Investigator 骨髄系腫瘍 / 核酸医薬 / 脂質ナノ粒子 / CRISPR/Cas13 / NEAT1 / lncRNA / Split-GFP / タンパク質間相互作用 / ASXL1 / 腫瘍免疫 … More / 造血器腫瘍 / RUNX1 / 白血病幹細胞 / 白血病 / 造血幹細胞 / MECOM / 骨髄不全 / 遺伝子治療 / Cas13 / NONO / CRISPR-Cas13 / 白血病融合遺伝子 / siRNA / 多能性幹細胞 / シングルセルRNA-seq / 臍帯血 / MLL-AF4 / リンパ性白血病 / 乳児白血病 / ユビキチンリガーゼ / プロテオスタシス / STUB1 / Split-TurboID / Alphascreen / ユビキチン / 熱ショックタンパク質 / EVI1 / CBFB / エピゲノム因子 / エピゲノム制御因子 / 転写因子 / 固形腫瘍 / クローン性造血 / 免疫不全マウス / MLL転座型白血病 / ヒストン脱アセチル化阻害剤 / 骨髄異形成症候群 / 急性骨髄性白血病 / ヒストンアセチル化阻害剤 / DNAメチル化阻害剤 / p53 / エピジェネティクス / ユビキチン化修飾 / ヒストンメチル化酵素 / Pbxl / MLL / 分子標的療法 / mTorシグナル伝達経路 / Akt / Pten / マウス白血病モデル / 難治性白血病 / Evi-1 / 新規治療法 / モデルマウス / Evi1 / Evil … More Except Principal Investigator システム生物学 / 薬剤標的性 / ab initio遺伝子軌道法 / 造血器腫瘍 / 白血病 / Evi-1 / CD155 / TIGIT / DNAM-1 / CD112 / NK細胞 / AML / ストレス応答 / パラスペックル / シグナル伝達 / 蛋白質分解 / 炎症 / ASXL1 / エピジェネティクス / 免疫チェックポイント / 情報物理学 / 腫瘍生物学 / ゲノム科学 / 生体生命情報学 / ネットワーク / 遺伝子 / バイオインフォマティクス / 血液内科学 / 情報理論 / 生物物理学 / ゲノム編集 / ab initio 遺伝子軌道法 / hematopoietic tumors / long non-coding RNA / bioinformatics / 固形癌 / 心血管系疾患 / LDLレセプター / HHEX / 動脈硬化 / クローン性造血 / hematopoietic stem cell / knockout mice / oligomerization / isoform / leukemia / AP-1 / AML1-Evi-1 / CtBP / TGF-β / 造腫瘍性 / 多量体 / 造血幹細胞 / ノックアウトマウス / 多量体化 / アイソフォーム Less

Development of In Vivo Gene Therapy for Bone Marrow Failure SyndromePrincipal Investigator
- Principal Investigator
  
  合山進
- Project Period (FY)
  2024 – 2025
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 54:Internal medicine of the bio-information integration and related fields
- Research Institution
  The University of Tokyo
Comprehensive identification of immune checkpoints in hematopoietic tumors using Ab initio genetic orbital method
- Principal Investigator
  
  森努
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Fukushima Medical University
DNAM-1/TIGIT/CD155/CD112を標的としたAMLに対する免疫療法の開発
- Principal Investigator
  
  今井陽一
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Dokkyo Medical University
Analyses of biological roles and significance of nuclear paraspeckles, formed by LLPS, liquid-liquid phase separation
- Principal Investigator
  
  KITAMURA TOSHIO
- Project Period (FY)
  2022 – 2023
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 54:Internal medicine of the bio-information integration and related fields
- Research Institution
  The University of Tokyo
Identification of the cell of origin of infant leukemia with pluripotencyPrincipal Investigator
- Principal Investigator
  
  Goyama Susumu
- Project Period (FY)
  2022 – 2023
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 54:Internal medicine of the bio-information integration and related fields
- Research Institution
  The University of Tokyo
Development of RNA-targeting drugs for hematopoietic neoplasmsPrincipal Investigator
- Principal Investigator
  
  合山進
- Project Period (FY)
  2022 – 2025
- Research Category
  
  Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))
- Review Section
  
  Medium-sized Section 54:Internal medicine of the bio-information integration and related fields
- Research Institution
  The University of Tokyo
Identification of tumor driver lncRNAs in myeloid tumors and development of lncRNA-targeting therapiesPrincipal Investigator
- Principal Investigator
  
  合山進
- Project Period (FY)
  2022 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  The University of Tokyo
Development of proteostasis modulators targeting the co-chaperon E3 ligase STUB1Principal Investigator
- Principal Investigator
  
  合山進
- Project Period (FY)
  2021 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Complex systems
- Research Institution
  The University of Tokyo
Integrated functional analysis of lncRNAs in hematopoietic tumors using the Ab initio method
- Principal Investigator
  
  Mori Tsutomu
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Fukushima Medical University
Crosstalk between clonal hematopoiesis and solid tumorsPrincipal Investigator
- Principal Investigator
  
  Goyama Susumu
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 50:Oncology and related fields
- Research Institution
  The University of Tokyo
Targeting transcription and epigenetic factors through modulation of protein-protein interactionsPrincipal Investigator
- Principal Investigator
  
  Goyama Susumu
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  The University of Tokyo
Analyses of relationship between clonal hematopoiesis associated with leukemia-related gene mutations and leukemia/solid tumors/cardiovascular diseases
- Principal Investigator
  
  Kitamura Toshio
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 54:Internal medicine of the bio-information integration and related fields
- Research Institution
  The University of Tokyo
Ab initio analysis on the pathophysiology of hematopoietic neoplasms
- Principal Investigator
  
  Mori Tsutomu
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Research Field
  
  Internal medicine of the bio-information integration and related fields
- Research Institution
  Fukushima Medical University
Crosstalk between epigenetic therapy and anti-tumor immunity in the treatment of hematopoietic neoplasmsPrincipal Investigator
- Principal Investigator
  
  Goyama Susumu
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Hematology
- Research Institution
  The University of Tokyo
造血系転写因子RUNX1のユビキチン化修飾および分解制御機構の解明Principal Investigator
- Principal Investigator
  
  合山進
- Project Period (FY)
  2015
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Hematology
- Research Institution
  The University of Tokyo
Establishment of experimental model for leukemia to develop novel molecular therapyPrincipal Investigator
- Principal Investigator
  
  GOYAMA Susumu
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Hematology
- Research Institution
  The University of Tokyo
Evi1による造血幹細胞及び癌化の制御機構Principal Investigator
- Principal Investigator
  
  合山進
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Young Scientists (Start-up)
- Research Field
  
  Hematology
- Research Institution
  The University of Tokyo
Comprehensive analysis of oncogenic transcriptional factor Evi-1.
- Principal Investigator
  
  KUROKAWA Mineo
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Hematology
- Research Institution
  The University of Tokyo

[Book] EBM血液疾患の治療2023-2024(CBF白血病の治療)2023
- Author(s)
  合山進
- Total Pages
  574
- Publisher
  中外医学社
- ISBN
  9784498225404
- Data Source
  KAKENHI-PROJECT-22K19540
[Book] EBM血液疾患の治療2023-2024(CBF白血病の治療)2023
- Author(s)
  合山進
- Total Pages
  574
- Publisher
  中外医学社
- ISBN
  9784498225404
- Data Source
  KAKENHI-PROJECT-23K24360
[Journal Article] Modeling and therapeutic targeting of t(8;21) AML with/without TP53 deficiency2024
- Author(s)
  Zhang Wenyu、Li Jingmei、Yamamoto Keita、Goyama Susumu
- Journal Title
  
  International Journal of Hematology
  
  Volume: in press Issue: 2 Pages: 186-193
- DOI
  10.1007/s12185-024-03783-3
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K19540, KAKENHI-PROJECT-23K24360
[Journal Article] Hyperactive Natural Killer cells in Rag2 knockout mice inhibit the development of acute myeloid leukemia2023
- Author(s)
  Sugimoto Emi、Saito Takeshi、Yoshida Taku、Yamazaki Satoshi、Kaito Yuta、Imai Yoichi、Denda Tamami、Ota Yasunori、Fukuyama Tomofusa、Tanaka Yosuke、Enomoto Yutaka、Kitamura Toshio、Goyama Susumu
- Journal Title
  
  Communications Biology
  
  Volume: 6 Issue: 1 Pages: 1294-1294
- DOI
  10.1038/s42003-023-05606-3
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K07868, KAKENHI-PROJECT-22K19540, KAKENHI-PROJECT-23K24360
[Journal Article] Mitotic perturbation is a key mechanism of action of decitabine in myeloid tumor treatment.2023
- Author(s)
  Yabushita T, Chinen T, Nishiyama A, Asada S, Shimura R, Isobe T, Yamamoto K, Sato N, Enomoto Y, Tanaka Y, Fukuyama T, Satoh H, Kato K, Saitoh K, Ishikawa T, Soga T, Nannya Y, Fukagawa T, Nakanishi M, Kitagawa D, Kitamura T, Goyama S
- Journal Title
  
  Cell Rep.
  
  Volume: 42 Issue: 9 Pages: 113098-113098
- DOI
  10.1016/j.celrep.2023.113098
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K18113, KAKENHI-PROJECT-22KK0127, KAKENHI-PROJECT-22K19540, KAKENHI-ORGANIZER-19H05739, KAKENHI-PUBLICLY-22H04692, KAKENHI-PUBLICLY-23H04282, KAKENHI-PROJECT-22H00408, KAKENHI-PROJECT-23K24360
[Journal Article] 加齢とクローン性造血2023
- Author(s)
  合山進
- Journal Title
  
  BioClinica
  
  Volume: 38 Pages: 378-382
- Data Source
  KAKENHI-PROJECT-22K19540
[Journal Article] The E3 ligase DTX2 inhibits RUNX1 function by binding its C-terminus and prevents the growth of RUNX1-dependent leukemia cells.2023
- Author(s)
  Taishi Yonezawa, Hirotaka Takahashi, Yangying Hao, Chie Furukawa, Akiho Tsuchiya, Wenyu Zhang, Tsuyoshi Fukushima, Tomofusa Fukuyama, Tatsuya Sawasaki, Toshio Kitamura, Susumu Goyama
- Journal Title
  
  FEBS Journal
  
  Volume: in press
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-21H00274
[Journal Article] Immune checkpoint molecule DNAM-1/CD112 axis is a novel target for NK-cell therapy in acute myeloid leukemia2023
- Author(s)
  Kaito Yuta、Sugimoto Emi、Nakamura Fumi、Tsukune Yutaka、Sasaki Makoto、Yui Shunsuke、Yamaguchi Hiroki、Goyama Susumu、Nannya Yasuhito、Mitani Kinuko、Tamura Hideto、Imai Yoichi
- Journal Title
  
  Haematologica
  
  Volume: 109 Pages: 1107-1120
- DOI
  10.3324/haematol.2023.282915
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K07868, KAKENHI-PROJECT-20H05667
[Journal Article] 加齢とクローン性造血2023
- Author(s)
  合山進
- Journal Title
  
  BioClinica
  
  Volume: 38 Pages: 378-382
- Data Source
  KAKENHI-PROJECT-22KK0127
[Journal Article] The E3 ligase DTX2 inhibits RUNX1 function by binding its C terminus and prevents the growth of RUNX1‐dependent leukemia cells2023
- Author(s)
  Yonezawa Taishi、Takahashi Hirotaka、Hao Yangying、Furukawa Chie、Tsuchiya Akiho、Zhang Wenyu、Fukushima Tsuyoshi、Fukuyama Tomofusa、Sawasaki Tatsuya、Kitamura Toshio、Goyama Susumu
- Journal Title
  
  The FEBS Journal
  
  Volume: 290 Issue: 21 Pages: 5141-5157
- DOI
  10.1111/febs.16914
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K24360
[Journal Article] Multi-omics analysis defines highly refractory RAS burdened immature subgroup of infant acute lymphoblastic leukemia2022
- Author(s)
  Tomoya Isobe, Masatoshi Takagi, Aiko Sato-Otsubo, et al. (57人中28番目)
- Journal Title
  
  Nature Communications
  
  Volume: 13 Issue: 1 Pages: 4501-4501
- DOI
  10.1038/s41467-022-32266-4
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K12239, KAKENHI-PROJECT-22K19539, KAKENHI-PROJECT-22KK0119, KAKENHI-PROJECT-19H01031, KAKENHI-PROJECT-20H00528, KAKENHI-PROJECT-20H00537, KAKENHI-PROJECT-21H02948, KAKENHI-PROJECT-21H03549, KAKENHI-PROJECT-21K19405, KAKENHI-PROJECT-23K21431, KAKENHI-PROJECT-23K24360, KAKENHI-PROJECT-23K24368
[Journal Article] CHIP‐associated mutant ASXL1 in blood cells promotes solid tumor progression2022
- Author(s)
  Liu Xiaoxiao、Sato Naru、Shimosato Yuko、Wang Teh‐Wei、Denda Tamami、Chang Yu‐Hsuan、Yabushita Tomohiro、Fujino Takeshi、Asada Shuhei、Tanaka Yosuke、Fukuyama Tomofusa、Enomoto Yutaka、Ota Yasunori、Sakamoto Takeharu、Kitamura Toshio、Goyama Susumu
- Journal Title
  
  Cancer Science
  
  Volume: 113 Issue: 4 Pages: 1182-1194
- DOI
  10.1111/cas.15294
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03685, KAKENHI-PROJECT-19K07659, KAKENHI-PROJECT-22K19464, KAKENHI-PROJECT-22K19539, KAKENHI-PROJECT-20H00537
[Journal Article] IMPDH inhibition activates TLR‐VCAM1 pathway and suppresses the development of MLL‐fusion leukemia2022
- Author(s)
  Liu Xiaoxiao、Sato Naru、Yabushita Tomohiro、Li Jingmei、Jia Yuhan、Tamura Moe、Asada Shuhei、 Fujino Takeshi、Fukushima Tsuyoshi、Yonezawa Taishi、Tanaka Yosuke、et al. O'Brien Eric、 Mizukawa Benjamin、Mulloy James C、Sugiura Yuki、Takizawa Hitoshi、Shibata Takuma、Miyake Kensuke、Kitamura Toshio、Goyama Susumu
- Journal Title
  
  EMBO Molecular Medicine
  
  Volume: 15 Issue: 1
- DOI
  10.15252/emmm.202115631
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K19539, KAKENHI-PLANNED-22H05184, KAKENHI-PROJECT-20H00537, KAKENHI-PROJECT-21H04800, KAKENHI-PROJECT-23K24360
[Journal Article] Eliminating chronic myeloid leukemia stem cells by IRAK1/4 inhibitors2022
- Author(s)
  Tanaka Yosuke....Goyama Susumu、Komatsu Norio、Takaku Tomoiku、Kitamura Toshio
- Journal Title
  
  Nature Communications
  
  Volume: 13 Issue: 1 Pages: 271-271
- DOI
  10.1038/s41467-021-27928-8
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03685, KAKENHI-PROJECT-19H03688, KAKENHI-PROJECT-20K06477, KAKENHI-PROJECT-21K08376, KAKENHI-PROJECT-22K19539, KAKENHI-PROJECT-20H00537
[Journal Article] MDS cells impair osteolineage differentiation of MSCs via extracellular vesicles to suppress normal hematopoiesis.2022
- Author(s)
  Hayashi Y, Inoue D, et al.
- Journal Title
  
  Cell Reports
  
  Volume: VOLUME 39, ISSUE 6 Issue: 6 Pages: 110805-110805
- DOI
  10.1016/j.celrep.2022.110805
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K21622, KAKENHI-PROJECT-22K19539, KAKENHI-PROJECT-21K16258, KAKENHI-PROJECT-20H00537, KAKENHI-PROJECT-20H03711, KAKENHI-PROJECT-21H02711, KAKENHI-PROJECT-20J01911, KAKENHI-PROJECT-19K10024, KAKENHI-PROJECT-18KK0449, KAKENHI-PROJECT-20H03717, KAKENHI-PROJECT-21H02954
[Journal Article] RUNX1 Inhibition Using Lipid Nanoparticle-Mediated Silencing RNA Delivery as an Effective Treatment for Acute Leukemias2022
- Author(s)
  Iida Kohei、Tsuchiya Akiho、Tamura Moe、Yamamoto Keita、Kawata Shigehisa、Ishihara-Sugano Mitsuko、Kato Motohiro、Kitamura Toshio、Goyama Susumu
- Journal Title
  
  Experimental Hematology
  
  Volume: 112-113 Pages: 1-8
- DOI
  10.1016/j.exphem.2022.05.001
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K19539, KAKENHI-PROJECT-20H00537, KAKENHI-PROJECT-23K24360
[Journal Article] Mechanisms involved in hematopoietic stem cell aging2022
- Author(s)
  Fujino Takeshi、Asada Shuhei、Goyama Susumu、Kitamura Toshio
- Journal Title
  
  Cellular and Molecular Life Sciences
  
  Volume: 79 Issue: 9 Pages: 473-473
- DOI
  10.1007/s00018-022-04356-5
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K19539, KAKENHI-PROJECT-20H00537
[Journal Article] CRISPR/Cas9-mediated base-editing enables a chain reaction through sequential repair of sgRNA scaffold mutations2021
- Author(s)
  Fukushima, T., Tanaka, Y., Adachi, K., Masuyama, N., Tsuchiya, A., Asada, S., Ishiguro, S., Mori, H., Seki, M., Yachie, N., Goyama, S., Kitamura, T.
- Journal Title
  
  Scientific Reports
  
  Volume: 11 Issue: 1
- DOI
  10.1038/s41598-021-02986-6
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H00537, KAKENHI-PROJECT-19H03685, KAKENHI-PROJECT-21K07934
[Journal Article] A histone modifier, ASXL1, interacts with NONO and is involved in paraspeckle formation in hematopoietic cells2021
- Author(s)
  Yamamoto Keita、Goyama Susumu、Asada Shuhei、Fujino Takeshi、Yonezawa Taishi、Sato Naru、Takeda Reina、Tsuchiya Akiho、Fukuyama Tomofusa、Tanaka Yosuke、Yokoyama Akihiko、Toya Hikaru、Kon Ayana、Nannya Yasuhito、Onoguchi-Mizutani Rena、Nakagawa Shinichi、Hirose Tetsuro、Ogawa Seishi、Akimitsu Nobuyoshi、Kitamura Toshio
- Journal Title
  
  Cell Reports
  
  Volume: 36 Issue: 8 Pages: 109576-109576
- DOI
  10.1016/j.celrep.2021.109576
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-20H05377, KAKENHI-PUBLICLY-21H00274, KAKENHI-PLANNED-21H05276, KAKENHI-PROJECT-19H05656, KAKENHI-PROJECT-20H00537, KAKENHI-PROJECT-17H03604, KAKENHI-PROJECT-19H03685, KAKENHI-PROJECT-19H03694, KAKENHI-PROJECT-19J01570, KAKENHI-PROJECT-20K15988, KAKENHI-PLANNED-21H05274
[Journal Article] Mutant ASXL1 induces age-related expansion of phenotypic hematopoietic stem cells through activation of Akt/mTOR pathway2021
- Author(s)
  Fujino Takeshi、Goyama Susumu、Sugiura Yuki、Inoue Daichi、Asada Shuhei、Yamasaki Satoshi、Matsumoto Akiko、Yamaguchi Kiyoshi、Isobe Yumiko、Tsuchiya Akiho、Shikata Shiori、Sato Naru、Morinaga Hironobu、Fukuyama Tomofusa、Tanaka Yosuke、Fukushima Tsuyoshi、Takeda Reina、Yamamoto Keita、Honda Hiroaki et al
- Journal Title
  
  Nature Communications
  
  Volume: 12 Issue: 1 Pages: 1826-1826
- DOI
  10.1038/s41467-021-22053-y
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07563, KAKENHI-PROJECT-19K22546, KAKENHI-PLANNED-19H05746, KAKENHI-PROJECT-19H03693, KAKENHI-PROJECT-19J01570, KAKENHI-PROJECT-19H03685
[Journal Article] Acute myeloid leukemia stem cells2020
- Author(s)
  合山進
- Journal Title
  
  Rinsho Ketsueki
  
  Volume: 61 Issue: 4 Pages: 336-342
- DOI
  10.11406/rinketsu.61.336
- NAID
  130007839377
- ISSN
  0485-1439, 1882-0824
- Language
  Japanese
- Data Source
  KAKENHI-PROJECT-19H03685, KAKENHI-PROJECT-19K22554
[Journal Article] Acute myeloid leukemia stem cells from genomic and immunological perspectives2020
- Author(s)
  合山進
- Journal Title
  
  Rinsho Ketsueki
  
  Volume: 61 Issue: 9 Pages: 1130-1137
- DOI
  10.11406/rinketsu.61.1130
- NAID
  130007937125
- ISSN
  0485-1439, 1882-0824
- Language
  Japanese
- Data Source
  KAKENHI-PROJECT-19H03685, KAKENHI-PROJECT-19K22554
[Journal Article] Epigenetics in Normal and Malignant Hematopoiesis2017
- Author(s)
  Goyama, S
- Journal Title
  
  Cancer Science
  
  Volume: - Issue: 4 Pages: 553-562
- DOI
  10.1111/cas.13168
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15H04855, KAKENHI-PROJECT-16K15499, KAKENHI-PUBLICLY-17H05634
[Journal Article] 正常および白血病幹細胞におけるEvi-1の機能2010
- Author(s)
  合山進、黒川峰夫
- Journal Title
  
  Annual Review 血液
  
  Pages: 22-28
- Data Source
  KAKENHI-PROJECT-20790669
[Journal Article] EVI-1 interacts with histone methyltransferases SUV39H1 and G9a for transcriptional repression and bone marrow immortalization.2010
- Author(s)
  合山進, 仁田英理子, 吉野哲也, 賀古真一, 渡辺-大河内直子, 島辺宗健, 今井陽一, 高橋孝喜, 黒川峰夫
- Journal Title
  
  Leukemia 24(1)
  
  Pages: 81-88
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790669
[Journal Article] EVI-1 interacts with histone methyltransferases SUV39H1 and G9a for transcriptional repression and bone marrow immortalization2010
- Author(s)
  Goyama S, Nitta E, Yoshino T, Kako S, Watanabe-Okochi N, Shimabe M, Imai Y, Takahashi K, Kurokawa M.
- Journal Title
  
  Leukemia 24(1)
  
  Pages: 81-88
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790669
[Journal Article] 正常および白血病幹細胞におけるEvi-1の機能2010
- Author(s)
  合山進、黒川峰夫
- Journal Title
  
  Annual review血液
  
  Pages: 22-28
- Data Source
  KAKENHI-PROJECT-20790669
[Journal Article] Pathogenetic significance of ecotropic viral integration site-1 in hematological malignancies.2009
- Author(s)
  合山進, 黒川峰夫
- Journal Title
  
  Cancer Science 100(6)
  
  Pages: 990-995
- NAID
  10025146207
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790669
[Journal Article] Evi-1による造血幹細胞制御と白血病発症2009
- Author(s)
  合山進、黒川峰夫
- Journal Title
  
  血液・腫瘍科 58(3)
  
  Pages: 354-360
- NAID
  40019064494
- Data Source
  KAKENHI-PROJECT-20790669
[Journal Article] Pbx1 is a downstream target of Evi-1 in hematopoietic stem/progenitors and leukemic cells2009
- Author(s)
  Shimabe M, Goyama S, Watanabe-Okochi N, Yoshimi A, Ichikawa M, Imai Y, Kurokawa M.
- Journal Title
  
  Oncogene 28(49)
  
  Pages: 4364-4374
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790669
[Journal Article] Evi-1による造血幹細胞制御と白血病発症機構2009
- Author(s)
  合山進
- Journal Title
  
  Trends in Hematological Malignancies 1(2)
  
  Pages: 70-73
- Data Source
  KAKENHI-PROJECT-20790669
[Journal Article] Pbx1 is a downstream target of Evi-1 in hematopoietic stem/progenitors and leukemic cells.2009
- Author(s)
  島辺宗健, 合山進, 渡辺-大河内直子, 吉見昭英, 市川幹, 今井陽一, 黒川峰夫
- Journal Title
  
  Oncogene 28(49)
  
  Pages: 4364-4374
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790669
[Journal Article] Pathogenetic significance of ecotropic viral integration site-1 in hematological malignancies2009
- Author(s)
  Goyama S, Kurokawa M.
- Journal Title
  
  Cancer Science 100(6)
  
  Pages: 990-995
- NAID
  10025146207
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790669
[Journal Article] AML1-Evi-1 specifically transforms hematopoietic stem cells through fusion of the entire Evi-1 sequence to AML1.2008
- Author(s)
  Takeshita M, Ichikawa M, Nitta E, Goyama S, Asai T, Ogawa S, Chiba S, Kurokawa M.
- Journal Title
  
  Leukemia
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18890058
[Journal Article] Evi-1 is a critical regulator for hematopoietic stem cells and transformed leukemic cells2008
- Author(s)
  Goyama S, Yamamoto G, Shimabe M, Sato T, Ichikawa M, Ogawa S, Chiba S, Kurokawa M.
- Journal Title
  
  Cell Stem. Cell 3(2)
  
  Pages: 207-220
- NAID
  40019064494
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790669
[Journal Article] Evi-1 is a critical regulator for hematopoietic stem cells and transformed leukemic cells.2008
- Author(s)
  合山進, 山本豪, 島辺宗健, 佐藤智彦, 市川幹, 小川誠司, 千葉滋, 黒川峰夫
- Journal Title
  
  Cell Stem Cell 3(2)
  
  Pages: 207-220
- NAID
  40019064494
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790669
[Journal Article] AML1/Runx1 Negatively Regulates Quiescent Hematopoietic Stem Cells in Adult Hematopoiesis.2008
- Author(s)
  Ichikawa M, Goyama S, Asai T, Kawazu M, Nakagawa M, Takeshita M, Chiba S, Ogawa S, Kurokawa M.
- Journal Title
  
  Journal of Immunology
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18890058
[Journal Article] 転写因子と血液疾患2008
- Author(s)
  合山進、黒川峰夫
- Journal Title
  
  BioClinica 23(12)
  
  Pages: 19-25
- Data Source
  KAKENHI-PROJECT-20790669
[Journal Article] Evi-1 promotes para-aortic splanchnopleural hematopoiesis through up-regulation of GATA-2 and repression of TGF-β signaling2008
- Author(s)
  Sato T, Goyama S, Nitta E, Takeshita M, Yoshimi M, Nakagawa M, Kawazu M, Ichikawa M, Kurokawa M.
- Journal Title
  
  Cancer Science
- NAID
  10024008671
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18890058
[Journal Article] Early relapse of JAK2 V617F-positive chronic neutrophilic leukemia with central nervous system in filtration after unrelated bone marrow transplantation.2007
- Author(s)
  Kako S, Kanda Y, Sato T, Goyama S, Noda N, Shoda E, Oshima K, Inoue M, Izutsu K, Watanabe T, Motokura T, Chiba S, Fukayama M, Kurokawa M.
- Journal Title
  
  American Journal of Hematology 82
  
  Pages: 386-390
- Data Source
  KAKENHI-PROJECT-17390273
[Journal Article] Early relapse of JAK2 V617F-positive chronic neutrophilic leukemia with central nervous system infiltration after unrelated bone marrow transplantation.2007
- Author(s)
  Kako S, Kanda Y, Sato T, Goyama S, Noda N, Shoda E, Oshima K, Inoue M, Izutsu K, Watanabe T, Motokura T, Chiba S, Fukayama M, Kurokawa M
- Journal Title
  
  American Journal of Hematology 82・5
  
  Pages: 386-390
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390273
[Journal Article] Early relapse of JAK2 V617F-positive chronic neutrophilic leukemia with central nervous system infiltration after unrelated bone marrow transplantation.2007
- Author(s)
  Kako S, Kanda Y, Sato T, Goyama S, Noda N, Shoda E, Oshima K, Inoue M, Izutsu K, Watanabe T, Motokura T, Chiba S, Fukayama M, Kurokawa M.
- Journal Title
  
  American Journal of Hematology. 82(5)
  
  Pages: 386-390
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390273
[Journal Article] AML1/Runx1 rescues Notch1-null mutation-induced deficiency of para-aortic splanchnopleural hematopoiesis.2006
- Author(s)
  Nakagawa M, Ichikawa M, Kumano K, Goyama S, Kawazu M, Asai T, Ogawa S, Kurokawa M, Chiba S
- Journal Title
  
  Blood 108・10
  
  Pages: 3329-3334
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390273
[Journal Article] AML 1/Runx1 rescues Notchl-Null nutation-induced deficiency of para-aortic splanchnopleural hematopoiesis of para-aortic splanchnopleural hematopoiesis.2006
- Author(s)
  Nakagawa M, Ichikawa M, Kumano K, Goyama S, Kawazu M, Asai T, Ogawa S, Kurokawa M, Chiba S.
- Journal Title
  
  Blood 15
  
  Pages: 3329-3334
- Data Source
  KAKENHI-PROJECT-17390273
[Journal Article] AMI1/Runx1 rescues Notch1-null mutation-induced deficiency of para-aortic splanchnopleural hematopoiesis.2006
- Author(s)
  Nakagawa M, Ichikawa M, Kumano K, Goyama S, Kawazu M, Asai T, Ogawa S, Kurokawa M, Chiba S.
- Journal Title
  
  Blood. 108(10)
  
  Pages: 3329-3334
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390273
[Patent] 「物質送達キャリア及び組成物」2021
- Inventor(s)
  合山進、菅野美津子、川田滋久
- Industrial Property Rights Holder
  合山進、菅野美津子、川田滋久
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2021-146112
- Filing Date
  2021
- Overseas
- Data Source
  KAKENHI-PROJECT-19H03685
[Presentation] HDAC7 is a potential therapeutic target in Acute Erythroid Leukemia2024
- Author(s)
  張文宇、山本圭太、張育せん、薮下知宏、北村俊雄、合山進
- Organizer
  第28回造血器腫瘍研究会
- Data Source
  KAKENHI-PROJECT-22K19540
[Presentation] HDAC7 is a potential therapeutic target in AEL2024
- Author(s)
  Wenyu Zhang, Goyama S.
- Organizer
  若手国際シンポジウム
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22KK0127
[Presentation] HDAC7 is a potential therapeutic target in Acute Erythroid Leukemia2024
- Author(s)
  張文宇、山本圭太、張育せん, 薮下知宏、北村俊雄、合山進
- Organizer
  第28回造血器腫瘍研究会
- Data Source
  KAKENHI-PROJECT-22KK0127
[Presentation] カルシウム制御因子Atp2a2は骨髄系腫瘍においてin vivo特異的に増殖を抑制する2024
- Author(s)
  志村瑠香、田村萌、山本圭太、北村俊雄、合山進
- Organizer
  第28回造血器腫瘍研究会
- Data Source
  KAKENHI-PROJECT-22KK0127
[Presentation] HDAC7 is a potential therapeutic target in AEL2024
- Author(s)
  Wenyu Zhang, Goyama S
- Organizer
  若手国際シンポジウム
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K19540
[Presentation] HDAC7 is a potential therapeutic target in AEL2024
- Author(s)
  Wenyu Zhang, Goyama S
- Organizer
  若手国際シンポジウム
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K24360
[Presentation] カルシウム制御因子Atp2a2は骨髄系腫瘍においてin vivo特異的に増殖を抑制する2024
- Author(s)
  志村瑠香、田村萌、山本圭太、北村俊雄、合山進
- Organizer
  第28回造血器腫瘍研究会
- Data Source
  KAKENHI-PROJECT-22K19540
[Presentation] カルシウム制御因子Atp2a2は骨髄系腫瘍においてin vivo特異的に増殖を抑制する2024
- Author(s)
  志村瑠香、田村萌、山本圭太、北村俊雄、合山進
- Organizer
  第28回造血器腫瘍研究会
- Data Source
  KAKENHI-PROJECT-23K24360
[Presentation] HDAC7 is a potential therapeutic target in Acute Erythroid Leukemia2024
- Author(s)
  張文宇、山本圭太、張育せん、薮下知宏、北村俊雄、合山進
- Organizer
  第28回造血器腫瘍研究会
- Data Source
  KAKENHI-PROJECT-23K24360
[Presentation] SETDB1 suppresses interferon responses and NK cell-mediated immunosurveillance in monocytic AML2023
- Author(s)
  Chang YH, Fujino T, Yamamoto K, Enomoto Y, Kitamura T, Goyama S
- Organizer
  The 13th JSH International Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22KK0127
[Presentation] 白血病幹細胞と腫瘍免疫2023
- Author(s)
  合山進
- Organizer
  第18回がん分子標的治療学会
- Invited
- Data Source
  KAKENHI-PROJECT-22K19540
[Presentation] AMLゲノム解析全盛時代にあえてFAB分類の重要性を訴える2023
- Author(s)
  合山進
- Organizer
  第１５回茨城造血器腫瘍セミナー
- Invited
- Data Source
  KAKENHI-PROJECT-22KK0127
[Presentation] CRISPR-dCas9 activation全ゲノムスクリーニング法による骨髄系腫瘍に対するDecitabineの作用機序の解明2023
- Author(s)
  藪下知宏、知念拓実、西山敦哉、南谷泰仁、中西真、北川大樹、北村俊雄、合山進
- Organizer
  第40 回染色体ワークショップ、第21回核ダイナミクス研究会
- Data Source
  KAKENHI-PROJECT-23K24360
[Presentation] SETDB1 suppresses interferon responses and NK cell-mediated immunosurveillance in monocytic AML2023
- Author(s)
  Yu Hsuan Chang, Takeshi Fujino, Keita Yamamoto, Yutaka Enomoto, Toshio Kitamura, Susumu Goyama
- Organizer
  第85回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-23K24360
[Presentation] HDAC7 is a potential therapeutic target in acute erythroid leukemia2023
- Author(s)
  Wenyu Zhang, Keita Yamamoto, Yu Hsuan Chang, Tomohiro Yabushita, Yangying Hao, Jakushin Nakahara, Toshio Kitamura, Susumu Goyama
- Organizer
  第85回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-22KK0127
[Presentation] AMLゲノム解析全盛時代にあえてFAB分類の重要性を訴える2023
- Author(s)
  合山進
- Organizer
  第１５回茨城造血器腫瘍セミナー
- Invited
- Data Source
  KAKENHI-PROJECT-23K24360
[Presentation] Discovery of a Novel Immune Checkpoint KYNU by the Ab Initio Genetic Orbital Method2023
- Author(s)
  Tsutomu Mori, Takashi Kawamura, Susumu Goyama, Tsuyoshi Shirai
- Organizer
  日本バイオインフォマティクス学会年会
- Data Source
  KAKENHI-PROJECT-20K08716
[Presentation] Mutant ASXL1 promotes atherosclerosis development in mice via accelerated myeloid cell proliferation and dysregulation of innate immune pathway2023
- Author(s)
  Sato N, Goyama S, Kitamura T.
- Organizer
  The 13th JSH International Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K24360
[Presentation] SETDB1 suppresses interferon responses and NK cell-mediated immunosurveillance in monocytic AML2023
- Author(s)
  Yu-Hsuan Chang, Takeshi Fujino, Keita Yamamoto, Yutaka Enomoto, Toshio Kitamura, Susumu Goyama
- Organizer
  日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-22KK0127
[Presentation] SETDB1 suppresses interferon responses and NK cell-mediated immunosurveillance in monocytic AML.2023
- Author(s)
  Yu-Hsuan Chang, Takeshi Fujino, Keita Yamamoto, Yutaka Enomoto, Toshio Kitamura, Susumu Goyama.
- Organizer
  日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-22K19540
[Presentation] MECOM 症候群で認められる変異は、MECOM の転写活性化能及び造腫瘍性を喪失させる2023
- Author(s)
  飯田孝平、山本圭太、浅田修平、北村俊雄、合山進
- Organizer
  第27回造血器腫瘍研究会
- Data Source
  KAKENHI-PROJECT-22K19539
[Presentation] CRISPR-dCas9 activation全ゲノムスクリーニング法による骨髄系腫瘍に対するDecitabineの作用機序の解明2023
- Author(s)
  藪下知宏、知念拓実、西山敦哉、南谷泰仁、中西真、北川大樹、北村俊雄、合山進
- Organizer
  第40 回染色体ワークショップ、第21回核ダイナミクス研究会
- Data Source
  KAKENHI-PROJECT-22K19539
[Presentation] SETDB1 as a therapeutic target in monocytic AML2023
- Author(s)
  Goyama S
- Organizer
  Scientific Workshops on Myeloid Development
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22KK0127
[Presentation] Targeting TP53 for acute myeloid leukemia and its relation to tumor immunity.2023
- Author(s)
  Goyama S
- Organizer
  10th International MDM2 Workshop
- Invited
- Data Source
  KAKENHI-PROJECT-23K24360
[Presentation] AMLゲノム解析全盛時代にあえてFAB分類の重要性を訴える2023
- Author(s)
  合山進
- Organizer
  第１５回茨城造血器腫瘍セミナー
- Invited
- Data Source
  KAKENHI-PROJECT-22K19540
[Presentation] CRISPR-Cas: Biology and its application to Blood Research2023
- Author(s)
  合山進
- Organizer
  熊本大学医学・生命科学セミナー
- Invited
- Data Source
  KAKENHI-PROJECT-23K24360
[Presentation] SETDB1 suppresses interferon responses and NK cell-mediated immunosurveillance in monocytic AML2023
- Author(s)
  Yu Hsuan Chang, Takeshi Fujino, Keita Yamamoto, Yutaka Enomoto, Toshio Kitamura, Susumu Goyama
- Organizer
  第85回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-22K19540
[Presentation] HDAC7 is a potential therapeutic target in acute erythroid leukemia.2023
- Author(s)
  Wenyu Zhang, Keita Yamamoto, Yu Hsuan Chang, Tomohiro Yabushita, Yangying Hao, Jakushin Nakahara, Toshio Kitamura, Susumu Goyama.
- Organizer
  第85回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-22K19540
[Presentation] ASXL1-CHIP は万病の元2023
- Author(s)
  合山進
- Organizer
  第６回腫瘍循環器学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-23K24360
[Presentation] HDAC7 is a potential therapeutic target in acute erythroid leukemia2023
- Author(s)
  Zheng W, Yamamoto K, Chang YH, Yabushita T, Kitamura T, Goyama S
- Organizer
  The 13th JSH International Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22KK0127
[Presentation] NK細胞の役割とDecitabineの作用機序を考える2023
- Author(s)
  合山進
- Organizer
  第82回佐賀ブルートアーベント
- Invited
- Data Source
  KAKENHI-PROJECT-22K19540
[Presentation] ASXL1-CHIP は万病の元2023
- Author(s)
  合山進
- Organizer
  第６回腫瘍循環器学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-22K19540
[Presentation] SETDB1 Suppresses Interferon Responses and NK Cell-Mediated Immunosurveillance Specifically in Monocytic AML.2023
- Author(s)
  Chang YH, Fujino T, Yamamoto K, Enomoto Y, Kitamura T, Goyama S.
- Organizer
  65th Annual meeting of American Society of Hematology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K24360
[Presentation] SETDB1 Suppresses Interferon Responses and NK Cell-Mediated Immunosurveillance Specifically in Monocytic AML2023
- Author(s)
  Goyama S
- Organizer
  Scientific Workshops on Myeloid Development
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K24360
[Presentation] SETDB1 suppresses interferon responses and NK cell-mediated immunosurveillance in monocytic AML.2023
- Author(s)
  Yu-Hsuan Chang, Takeshi Fujino, Keita Yamamoto, Yutaka Enomoto, Toshio Kitamura, Susumu Goyama.
- Organizer
  日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-23K24360
[Presentation] MECOM 症候群で認められる変異は、 MECOM の転写活性化能及び造腫瘍性を喪失させる2023
- Author(s)
  飯田孝平、山本圭太、浅田修平、北村俊雄、合山進
- Organizer
  第27回造血器腫瘍研究会
- Data Source
  KAKENHI-PROJECT-23K24360
[Presentation] AML治療新時代：NK細胞の役割とDecitabineの作用機序を考える2023
- Author(s)
  合山進
- Organizer
  第82回佐賀ブルートアーベント
- Invited
- Data Source
  KAKENHI-PROJECT-22KK0127
[Presentation] Identification of a Novel Immune Checkpoint KYNU by the Ab Initio Genetic Orbital Method2023
- Author(s)
  Tsutomu Mori, Takashi Kawamura, Susumu Goyama
- Organizer
  日本癌学会学術総会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K08716
[Presentation] SETDB1 suppresses interferon responses and NK cell-mediated immunosurveillance in monocytic AML2023
- Author(s)
  Chang YH, Fujino T, Yamamoto K, Enomoto Y, Kitamura T, Goyama S.
- Organizer
  The 13th JSH International Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K19540
[Presentation] Identification of tumor regulators in myeloid neoplasms using in vivo CRISPR- Cas9 screening2023
- Author(s)
  Yu-Hsuan Chang, Takeshi Fujino, Toshio Kitamura, Susumu Goyama
- Organizer
  第27回造血器腫瘍研究会
- Data Source
  KAKENHI-PROJECT-22K19540
[Presentation] Ab initio遺伝子軌道法による新規免疫チェックポイントKYNUの同定2023
- Author(s)
  森努，合山進
- Organizer
  第42回日本トリプトファン研究会学術集会
- Data Source
  KAKENHI-PROJECT-20K08716
[Presentation] Targeting TP53 for acute myeloid leukemia and its relation to tumor immunity.2023
- Author(s)
  Goyama S
- Organizer
  10th International MDM2 Workshop
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K19540
[Presentation] SETDB1 Suppresses Interferon Responses and NK Cell-Mediated Immunosurveillance Specifically in Monocytic AML2023
- Author(s)
  Chang YH, Fujino T, Yamamoto K, Enomoto Y, Kitamura T, Goyama S.
- Organizer
  Annual meeting of American Society of Hematology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22KK0127
[Presentation] 白血病幹細胞と腫瘍免疫2023
- Author(s)
  合山進
- Organizer
  第18回がん分子標的治療学会
- Invited
- Data Source
  KAKENHI-PROJECT-23K24360
[Presentation] SETDB1 as a therapeutic target in monocytic AML2023
- Author(s)
  Goyama S
- Organizer
  Scientific Workshops on Myeloid Development
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K19540
[Presentation] NK細胞の役割とDecitabineの作用機序を考える2023
- Author(s)
  合山進
- Organizer
  第82回佐賀ブルートアーベント
- Invited
- Data Source
  KAKENHI-PROJECT-23K24360
[Presentation] SETDB1 Suppresses Interferon Responses and NK Cell-Mediated Immunosurveillance Specifically in Monocytic AML.2023
- Author(s)
  Chang YH, Fujino T, Yamamoto K, Enomoto Y, Kitamura T, Goyama S.
- Organizer
  65th Annual meeting of American Society of Hematology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K19540
[Presentation] HDAC7 is a potential therapeutic target in acute erythroid leukemia2023
- Author(s)
  Zheng W, Yamamoto K, Chang YH, Yabushita T, Kitamura T, Goyama S.
- Organizer
  The 13th JSH International Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K24360
[Presentation] CRISPR-Cas: Biology and its application to Blood Research2023
- Author(s)
  合山進
- Organizer
  熊本大学医学・生命科学セミナー
- Invited
- Data Source
  KAKENHI-PROJECT-22K19540
[Presentation] Identification of tumor regulators in myeloid neoplasms using in vivo CRISPR-Cas9 screening2023
- Author(s)
  Yu-Hsuan Chang, Takeshi Fujino, Toshio Kitamura, Susumu Goyama
- Organizer
  第27回造血器腫瘍研究会
- Data Source
  KAKENHI-PROJECT-22K19539
[Presentation] MECOM 症候群で認められる変異は、 MECOM の転写活性化能及び造腫瘍性を喪失させる2023
- Author(s)
  飯田孝平、山本圭太、浅田修平、北村俊雄、合山進
- Organizer
  第27回造血器腫瘍研究会
- Data Source
  KAKENHI-PROJECT-22K19540
[Presentation] Identification of tumor regulators in myeloid neoplasms using in vivo CRISPR- Cas9 screening2023
- Author(s)
  Yu-Hsuan Chang, Takeshi Fujino, Toshio Kitamura, Susumu Goyama
- Organizer
  第27回造血器腫瘍研究会
- Data Source
  KAKENHI-PROJECT-23K24360
[Presentation] SETDB1 suppresses interferon responses and NK cell-mediated immunosurveillance in monocytic AML2023
- Author(s)
  Chang YH, Fujino T, Yamamoto K, Enomoto Y, Kitamura T, Goyama S.
- Organizer
  The 13th JSH International Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K24360
[Presentation] CRISPR-Cas: Biology and its application to Blood Research.2023
- Author(s)
  合山進
- Organizer
  熊本大学医学・生命科学セミナー
- Invited
- Data Source
  KAKENHI-PROJECT-22KK0127
[Presentation] HDAC7 is a potential therapeutic target in acute erythroid leukemia.2023
- Author(s)
  Wenyu Zhang, Keita Yamamoto, Yu Hsuan Chang, Tomohiro Yabushita, Yangying Hao, Jakushin Nakahara, Toshio Kitamura, Susumu Goyama.
- Organizer
  第85回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-23K24360
[Presentation] Dual targeting of mTOR and p53 shows potent activity against aggressive acute myeloid leukemia.2023
- Author(s)
  Jingmei Li, Emi Sugimoto, Keita Yamamoto, Toshio Kitamura, Susumu Goyama.
- Organizer
  第85回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-23K24360
[Presentation] Dual targeting of mTOR and p53 shows potent activity against aggressive acute myeloid leukemia.2023
- Author(s)
  Jingmei Li, Emi Sugimoto, Keita Yamamoto, Toshio Kitamura, Susumu Goyama.
- Organizer
  第85回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-22K19540
[Presentation] Identification of tumor regulators in myeloid neoplasms using in vivo CRISPR- Cas9 screening2023
- Author(s)
  Yu-Hsuan Chang, Takeshi Fujino, Toshio Kitamura, Susumu Goyama
- Organizer
  造血器腫瘍研究会
- Data Source
  KAKENHI-PROJECT-22KK0127
[Presentation] CRISPR-dCas9 activation全ゲノムスクリーニング法による骨髄系腫瘍に対するDecitabineの作用機序の解明2023
- Author(s)
  藪下知宏、知念拓実、西山敦哉、南谷泰仁、中西真、北川大樹、北村俊雄、合山進
- Organizer
  第40 回染色体ワークショップ、第21回核ダイナミクス研究会
- Data Source
  KAKENHI-PUBLICLY-21H00274
[Presentation] HDAC7 is a potential therapeutic target in acute erythroid leukemia.2023
- Author(s)
  Zheng W, Yamamoto K, Chang YH, Yabushita T, Kitamura T, Goyama S.
- Organizer
  The 13th JSH International Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K19540
[Presentation] SETDB1 suppresses interferon responses and NK cell-mediated immunosurveillance in monocytic AML2023
- Author(s)
  Yu Hsuan Chang, Takeshi Fujino, Keita Yamamoto, Yutaka Enomoto, Toshio Kitamura, Susumu Goyama
- Organizer
  第85回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-22KK0127
[Presentation] Mutant ASXL1 promotes atherosclerosis development in mice via accelerated myeloid cell proliferation and dysregulation of innate immune pathway2023
- Author(s)
  Sato N, Goyama S, Kitamura T.
- Organizer
  The 13th JSH International Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K19540
[Presentation] 白血病幹細胞と腫瘍免疫2022
- Author(s)
  合山進
- Organizer
  第36回臨床血液セミナー
- Invited
- Data Source
  KAKENHI-PROJECT-23K24360
[Presentation] In vivo CRISPR/Cas9ライブラリスクリーニングにより明らかとなった急性骨髄性白血病におけるAtp2a2の腫瘍抑制因子としての役割2022
- Author(s)
  志村瑠香、北村俊雄、合山進
- Organizer
  第81回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-22K19539
[Presentation] MECOM症候群で認められる変異は、MECOMの転写活性化能及び造腫瘍性を喪失させる2022
- Author(s)
  飯田孝平、山本圭太、浅田修平、北村俊雄、合山進
- Organizer
  第84回日本血液学会
- Data Source
  KAKENHI-PROJECT-22K19539
[Presentation] unable knockdown of target genes by the novel CRISPR/Cas13 degron system2022
- Author(s)
  Keita Yamamoto, Susumu Goyama
- Organizer
  Ubiquitin New Frontier
- Data Source
  KAKENHI-PUBLICLY-21H00274
[Presentation] Development of proteostasis modulators targeting the co-chaperon E3 ligase STUB12022
- Author(s)
  Yangying Hao, Susumu Goyama
- Organizer
  Ubiquitin New Frontier
- Data Source
  KAKENHI-PUBLICLY-21H00274
[Presentation] Decitabine induces excessive DNA-DNMT1 crosslinks and perturbs faithful mitosis of myeloid tumors2022
- Author(s)
  Tomohiro Yabushita, Shuhei Asada, Keita Yamamoto, Naru Sato, Yutaka Enomoto, Yosuke Tanaka, Tomofusa Fukuyama, Atsuya Nishiyama, Makoto Nakanishi, Toshio Kitamura, Susumu Goyama
- Organizer
  第84回日本血液学会総会
- Data Source
  KAKENHI-PROJECT-23K24360
[Presentation] 健康長寿実現のために、CHIPとどう向き合うか？2022
- Author(s)
  合山進
- Organizer
  第81回日本癌学会学術総会
- Invited
- Data Source
  KAKENHI-PROJECT-23K24360
[Presentation] Decitabine induces excessive DNA-DNMT1 crosslinks and perturbs faithful mitosis of myeloid tumors2022
- Author(s)
  Tomohiro Yabushita, Shuhei Asada, Keita Yamamoto, Naru Sato, Yutaka Enomoto, Yosuke Tanaka, Tomofusa Fukuyama, Atsuya Nishiyama, Makoto Nakanishi, Toshio Kitamura, Susumu Goyama
- Organizer
  The 84rd Annual Meeting of JSH
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K19539
[Presentation] Mitotic Perturbation Is a Key Mechanism of Action of Decitabine in Myeloid Tumor Treatment2022
- Author(s)
  Tomohiro Yabushita, Takumi Chinen, Atsuya Nishiyama, Shuhei Asada, Keita Yamamoto, Naru Sato, Yutaka Enomoto, osuke Tanaka, Keiko Katoh, Kaori Saitoh, Takamasa Ishikawa, Hitoshi Sato, Tomoyoshi Soga, Yasuhito Nannya, Makoto Nakanishi, Daiju Kitagawa, Toshio Kitamura, Susumu Goyama
- Organizer
  64th American Society of Hematology (ASH) Annual Meeting and Exposition New Orleans
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K19539
[Presentation] In vivo CRISPR/Cas9ライブラリスクリーニングにより明らかとなった急性骨髄性白血病におけるAtp2a2の腫瘍抑制因子としての役割2022
- Author(s)
  志村瑠香、北村俊雄、合山進
- Organizer
  第81回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-23K24360
[Presentation] Mitotic Perturbation Is a Key Mechanism of Action of Decitabine in Myeloid Tumor Treatment2022
- Author(s)
  Tomohiro Yabushita, Takumi Chinen, Atsuya Nishiyama, Shuhei Asada, Keita Yamamoto, Naru Sato, Yutaka Enomoto, Yosuke Tanaka,Keiko Katoh, Kaori Saitoh, Takamasa Ishikawa, Hitoshi Sato, Tomoyoshi Soga, Yasuhito Nannya, Makoto Nakanishi, Daiju Kitagawa,Toshio Kitamura, Susumu Goyama
- Organizer
  The 64th American Society of Hematology (ASH) Annual Meeting and Exposition
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K24360
[Presentation] Mitotic Perturbation Is a Key Mechanism of Action of Decitabine in Myeloid Tumor Treatment2022
- Author(s)
  Tomohiro Yabushita, Takumi Chinen, Atsuya Nishiyama, Shuhei Asada, Keita Yamamoto, Naru Sato, Yutaka Enomoto, Yosuke Tanaka,Keiko Katoh, Kaori Saitoh, Takamasa Ishikawa, Hitoshi Sato, Tomoyoshi Soga, Yasuhito Nannya, Makoto Nakanishi, Daiju Kitagawa,Toshio Kitamura, Susumu Goyama
- Organizer
  64th American Society of Hematology (ASH) Annual Meeting and Exposition
- Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-21H00274
[Presentation] 健康長寿実現のために、CHIPとどう向き合うか？2022
- Author(s)
  合山進
- Organizer
  第81回日本癌学会学術総会
- Invited
- Data Source
  KAKENHI-PROJECT-22K19540
[Presentation] 白血病幹細胞と腫瘍免疫2022
- Author(s)
  合山進
- Organizer
  第36回臨床血液セミナー
- Invited
- Data Source
  KAKENHI-PROJECT-22K19540
[Presentation] ASXL1によるパラスペックル制御と白血病2022
- Author(s)
  山本圭太、合山進、北村俊雄
- Organizer
  第81回日本癌学会学術総会
- Invited
- Data Source
  KAKENHI-PROJECT-23K24360
[Presentation] ASXL1によるパラスペックル制御と白血病2022
- Author(s)
  山本圭太、合山進、北村俊雄
- Organizer
  第81回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-22K19539
[Presentation] ASXL1によるパラスペックル制御と白血病2022
- Author(s)
  山本圭太、合山進、北村俊雄
- Organizer
  第81回日本癌学会学術集会
- Invited
- Data Source
  KAKENHI-PUBLICLY-21H00274
[Presentation] Decitabine induces excessive DNA-DNMT1 crosslinks and perturbs faithful mitosis of myeloid tumors2022
- Author(s)
  Tomohiro Yabushita, Shuhei Asada, Keita Yamamoto, Naru Sato, Yutaka Enomoto, Yosuke Tanaka, Tomofusa Fukuyama, Atsuya Nishiyama, Makoto Nakanishi, Toshio Kitamura, Susumu Goyama
- Organizer
  第84回日本血液学会学術集会
- Data Source
  KAKENHI-PUBLICLY-21H00274
[Presentation] Biochemical and functional analysis of STUB1-HSP70/90 complex2021
- Author(s)
  カク楊穎、合山進
- Organizer
  新学術領域研究「ケモユビキチン」第3回若手主体発表会
- Data Source
  KAKENHI-PUBLICLY-21H00274
[Presentation] タンパク質工学を活用した転写因子標的療法の開発2021
- Author(s)
  合山進
- Organizer
  先端医療シーズ開発フォーラム
- Invited
- Data Source
  KAKENHI-PROJECT-19H03685
[Presentation] イマチニブとIRAK1/4 阻害剤との併用は慢性骨髄性白血病幹細胞の駆逐に効果的である2021
- Author(s)
  田中洋介、竹田玲奈、福島剛、合山進、北村俊雄
- Organizer
  第83回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-19H03685
[Presentation] A histone modifier ASXL1 interacts with NONO and is involved in paraspeckle formation in hematopoietic cells2021
- Author(s)
  山本圭太、合山進、浅田修平、藤野赳至、米澤太志、佐藤成、竹田玲奈、福山朋房、田中洋介、横山明彦、昆彩奈、南谷泰仁、小野口玲菜、秋光信佳、小川誠司、北村俊雄
- Organizer
  第83回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-19H03685
[Presentation] ASXL1変異を伴う血液細胞が固形腫瘍の発症、進展に及ぼす影響2021
- Author(s)
  劉瀟瀟、北村俊雄、合山進
- Organizer
  第25回造血器腫瘍研究会
- Data Source
  KAKENHI-PROJECT-19H03685
[Presentation] 造血幹・前駆細胞におけるASXL1変異による核内構造体形成異常の解析2021
- Author(s)
  山本圭太、合山進、浅田修平、藤野赳至、米澤太志、佐藤成、竹田玲奈、福山朋房、田中洋介、横山明彦、昆彩奈、南谷泰仁、小川誠司、北村俊雄
- Organizer
  第25回造血器腫瘍研究会
- Data Source
  KAKENHI-PROJECT-19H03685
[Presentation] 造血幹・前駆細胞におけるASXL1変異による核内構造体形成異常の解析2021
- Author(s)
  山本圭太、合山進、浅田修平、藤野赳至、米澤太志、佐藤成、竹田玲奈、福山朋房、田中洋介、横山明彦、昆彩奈、南谷泰仁、小川誠司、北村俊雄
- Organizer
  第25回造血器腫瘍研究会
- Data Source
  KAKENHI-PROJECT-19K22554
[Presentation] リピッドナノパーティクルを活用したRUNX1ノックダウンは、T細胞白血病の増殖を抑制する2021
- Author(s)
  飯田孝平、土屋秋穂、川田滋久、菅野美津子、合山進
- Organizer
  第83回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-19H03685
[Presentation] p53活性化薬は、NK細胞と協調して急性骨髄性白血病の発症を抑制する2021
- Author(s)
  合山進、杉本絵美、北村俊雄
- Organizer
  第80回日本癌学会学術総会
- Invited
- Data Source
  KAKENHI-PROJECT-19H03685
[Presentation] Asxl1 と Stag2 の変異は協調して遺伝子発現を変化させ骨髄異形成症候群の発症を誘導する2021
- Author(s)
  藤野赳至、越智陽太郎、昆彩奈、合山進、小川誠司、北村俊雄
- Organizer
  第25回造血器腫瘍研究会
- Data Source
  KAKENHI-PROJECT-19H03685
[Presentation] ASXL1変異を伴う血液細胞が固形腫瘍の発症、進展に及ぼす影響2021
- Author(s)
  劉瀟瀟、北村俊雄、合山進
- Organizer
  第25回造血器腫瘍研究会
- Data Source
  KAKENHI-PROJECT-19K22554
[Presentation] Hyperactive NK cells in Rag2-deficient mice suppress the development of acute myeloid leukemia2021
- Author(s)
  杉本絵美、合山進、林康貴、浅田修平、福島剛、川瀬竜也、斎藤健、吉田卓、山崎聡、海渡裕太、今井陽一、福山朋房、田中洋介、榎本豊、北村俊雄
- Organizer
  第83回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-19H03685
[Presentation] Biochemical and functional analysis of STUB1-HSP70/90 complex2021
- Author(s)
  カク楊穎、合山進
- Organizer
  新学術領域研究「ケモユビキチン」第4回若手主体発表会
- Data Source
  KAKENHI-PUBLICLY-21H00274
[Presentation] Somatic ASXL1 mutation in blood cells promote solid tumor progression2021
- Author(s)
  劉瀟瀟、佐藤成、北村俊雄、合山進
- Organizer
  第80回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-19H03685
[Presentation] A histone modifier ASXL1 interacts with NONO and is involved in paraspeckle formation in hematopoietic cells2021
- Author(s)
  山本圭太、合山進、浅田修平、藤野赳至、米澤太志、佐藤成、竹田玲奈、福山朋房、田中洋介、横山明彦、昆彩奈、南谷泰仁、小野口玲菜、秋光信佳、小川誠司、北村俊雄
- Organizer
  第83回日本血液学会学術集会
- Data Source
  KAKENHI-PUBLICLY-21H00274
[Presentation] Hyperactive NK cells in Rag2-deficient mice suppress the development of acute myeloid leukemia2021
- Author(s)
  杉本絵美、合山進、林康貴、浅田修平、海渡裕太、今井陽一、福山朋房、田中洋介、北村俊雄
- Organizer
  第80回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-19H03685
[Presentation] Combination of ASXL1 mutation and Stag2 loss lead to development of myelodysplastic syndromes2020
- Author(s)
  藤野赳至、越智陽太郎、昆彩奈、合山進、小川誠司、北村俊雄
- Organizer
  第８２回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-19H03685
[Presentation] Mutant ASXL1 induces expansion of hematopoietic stem cells through activation of Akt/mTOR pathway2020
- Author(s)
  藤野赳至、合山進、Yuki Sugiura、井上大地、浅田修平、Satoshi Yamasaki、Akiko Matsumoto、Kiyoshi Yamaguchi、土屋秋穂、四方紫織、佐藤成、Hironobu Morinaga、福山朋房、田中洋介、福島剛、竹田玲奈、山本圭太、本田浩章、Emi K. Nishimura、古川洋一、Tatsuhiro Shibata、Omar Abdel-Wahab、末松誠、北村俊雄
- Organizer
  ISEH 2020 Virtual Scientific Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K22554
[Presentation] Mutant ASXL1 induces expansion of hematopoietic stem cells through activation of Akt/mTOR pathway2020
- Author(s)
  藤野赳至、合山進、Yuki Sugiura、井上大地、浅田修平、Satoshi Yamasaki、Akiko Matsumoto、Kiyoshi Yamaguchi、土屋秋穂、四方紫織、佐藤成、Hironobu Morinaga、福山朋房、田中洋介、福島剛、竹田玲奈、山本圭太、本田浩章、Emi K. Nishimura、古川洋一、Tatsuhiro Shibata、Omar Abdel-Wahab、末松誠、北村俊雄
- Organizer
  ISEH 2020 Virtual Scientific Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03685
[Presentation] Epigenetic Regulator ASXL1 Promotes Paraspeckle Formation through C-terminal Intrinsically Disordered Region in Hematopoietic Cells2020
- Author(s)
  山本圭太、合山進、北村俊雄
- Organizer
  ISEH 2020 Virtual Scientific Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03685
[Presentation] Clonal Hematopoiesis Associated with Mutant ASXL1 Accelerates Atherosclerosis in Mice2020
- Author(s)
  佐藤成、合山進、浅田修平、藤野赳至、劉瀟瀟、竹田玲奈、山本圭太、米澤大志、北村俊雄
- Organizer
  第82回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-19K22554
[Presentation] Epigenetic Regulator ASXL1 Promotes Paraspeckle Formation through C-terminal Intrinsically Disordered Region in Hematopoietic Cells2020
- Author(s)
  山本圭太、合山進、北村俊雄
- Organizer
  ISEH 2020 Virtual Scientific Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K22554
[Presentation] Clonal Hematopoiesis Associated with Mutant ASXL1 Accelerates Atherosclerosis in Mice2020
- Author(s)
  佐藤成、合山進、浅田修平、藤野赳至、劉瀟瀟、竹田玲奈、山本圭太、米澤大志、北村俊雄
- Organizer
  第82回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-19H03685
[Presentation] DTX2はRUNX1のユビキチン化および脱アセチル化を促進し、白血病細胞の増殖を抑制する2020
- Author(s)
  米澤大志、北村俊雄、合山進
- Organizer
  第79回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-19H03685
[Presentation] AML幹細胞 -ゲノム学および免疫学との融合-2020
- Author(s)
  合山進
- Organizer
  第８２回日本血液学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-19H03685
[Presentation] Mutant ASXL1 promotes age-associated progenitor expansion in native hematopoiesis2020
- Author(s)
  合山進、藤野赳至、浅田修平、北村俊雄
- Organizer
  Meeting of Leukemic and Hematopoietic Stem cells　in Kumamoto
- Data Source
  KAKENHI-PROJECT-18K19558
[Presentation] Development of RUNX1 inhibitor2019
- Author(s)
  米澤大志、高橋弘隆、澤崎達也、北村俊雄、合山進
- Organizer
  第三回乳癌転移若手研究会
- Data Source
  KAKENHI-PROJECT-19H03685
[Presentation] The ubiquitin ligase DTX2 promotes nuclear export of RUNX1 and inhibits RUNX1-dependent leukemogenesis2019
- Author(s)
  米澤大志、高橋弘隆、澤崎達也、北村俊雄、合山進
- Organizer
  The 61st American Society of Hematology annual meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03685
[Presentation] Development of RUNX1-CBFB interaction inhibitor for RUNX1-dependent leukemias2019
- Author(s)
  米澤大志、高橋弘隆、澤崎達也、北村俊雄、合山進
- Organizer
  第81回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-19H03685
[Presentation] Mutant ASXL1 Promotes Expansion of the Phenotypic Hematopoietic Stem Cell Compartment2019
- Author(s)
  Takeshi Fujino, Susumu Goyama, Yuki Sugiura, Daichi Inoue, Satoshi Yamasaki, Akiko Matsumoto, Naru Sato, Hironobu Morinaga, Shiori Shikata, Tomofusa Fukuyama, Yosuke Tanaka, Shuhei Asada, Tsuyoshi Fukushima, Hiroaki Honda, Emi K Nishimura, Tatsuhiro Shibata, Makoto Suematsu ,Toshio Kitamura
- Organizer
  The 61st American Society of Hematology annual meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K19558
[Presentation] Opposing effects of acute versus chronic inhibition of p53 on decitabine’s efficacy in myeloid neoplasms2019
- Author(s)
  田村萌、米澤大志、劉瀟瀟、浅田修平、林康貴、福山朋房、田中洋介、北村俊雄、合山進
- Organizer
  第81回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-18K19558
[Presentation] Mutant ASXL1 cooperates with homeobox transcription factor HHEX to promote myeloid leukemogenesis2019
- Author(s)
  竹田玲奈、浅田修平、井上大地、福山朋房、合山進、北村俊雄
- Organizer
  第81回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-18K19558
[Presentation] Leukemogenic Functions of Mutant ASXL1 Are Regulated By CDK-Mediated Phosphorylation2019
- Author(s)
  浅田修平、合山進、竹田玲奈、山本圭太、秦(小塚)裕子、尾山正明、井上大地、本田浩章、北村俊雄
- Organizer
  The 61st American Society of Hematology annual meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K19558
[Presentation] Homeobox Transcription Factor HHEX Promotes Myeloid Leukemia In Cooperation With Mutant ASXL12019
- Author(s)
  竹田玲奈、浅田修平、朴聖俊、横山明彦、金井昭教、Valeria Visconte、Courtney Hershberger、林康孝、米澤大志、田村萌、福山朋房、松本明子、山崎智、中井謙太、稲葉俊哉、柴田龍弘、井上大地、本田浩章、合山進、Jaroslaw P Maciejewski、北村俊雄
- Organizer
  The 61st American Society of Hematology annual meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K19558
[Presentation] 変異型ASXL1はAkt/mTORシグナルを活性化し造血幹細胞の生理的な老化を変化させる2019
- Author(s)
  藤野赳至、合山進、杉浦悠毅、井上大地、土屋秋穂、山崎智、松本明子、佐藤成、浅田修平、森永浩伸、四方紫織、永瀬玲奈、福山朋房、田中洋介、福島剛、竹田玲奈、山本圭太、本田浩章、西村栄美、柴田龍弘、Omar Abdel-Wahab、末松誠、北村俊雄
- Organizer
  第81回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-18K19558
[Presentation] Development of RUNX1-CBFB interaction inhibitor for RUNX1-dependent leukemias2019
- Author(s)
  米澤大志、高橋弘隆、澤崎達也、北村俊雄、合山進
- Organizer
  プロテインアイランド松山
- Data Source
  KAKENHI-PROJECT-19H03685
[Presentation] Tumor suppressor p53 inhibits myeloid leukemogenesis with the assistance of tumor immunity2018
- Author(s)
  合山進
- Organizer
  Japan Society for the Promotion of Science & National University of Singapore, Joint 2nd symposium
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K15499
[Presentation] Therapy-resistant myeloid leukemia stem cells2017
- Author(s)
  合山進
- Organizer
  The Stem Cell Biology and Regenerative Medicine Retreat
- Data Source
  KAKENHI-PROJECT-16K15499
[Presentation] A p53-MDM2 Interaction Inhibitor, DS-5272, Inhibits the Development of MLL-Fusion Leukemia with the Assistance of Tumor Immunity2017
- Author(s)
  合山進、林康貴、劉瀟瀟、四方紫織、田中洋介、福山朋房、山﨑智、松本明子、柴田龍弘、北村俊雄
- Organizer
  The 59th American Society of Hematology annual meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K15499
[Presentation] 白血病幹細胞の本態2017
- Author(s)
  合山進
- Organizer
  第１９回新潟血液研究会
- Invited
- Data Source
  KAKENHI-PROJECT-16K15499
[Presentation] 白血病幹細胞の本態2016
- Author(s)
  合山進
- Organizer
  第78回日本血液学会学術集会
- Place of Presentation
  横浜
- Year and Date
  2016-10-13
- Invited
- Data Source
  KAKENHI-PROJECT-16K15499
[Presentation] AMLの白血病幹細胞2016
- Author(s)
  合山進
- Organizer
  第10回神戸血液セミナー
- Place of Presentation
  神戸
- Year and Date
  2016-09-03
- Invited
- Data Source
  KAKENHI-PROJECT-16K15499
[Presentation] EVI1はポリコーム群を介してPTENの転写抑制しAKT/mTORシグナルを活性化する2009
- Author(s)
  吉見昭秀, 渡辺-大河内直子, 合山進, 南谷泰仁, 仁田英里子, 荒井俊也, 佐藤智彦, 島辺宗健, 中川正宏, 今井陽一, 北村俊雄, 黒川峰夫
- Organizer
  第68回日本癌学会学術総会
- Place of Presentation
  横浜
- Year and Date
  2009-10-03
- Data Source
  KAKENHI-PROJECT-20790669
[Presentation] 難治性白血病遺伝子Evi-1の分子生物的機能解析2009
- Author(s)
  合山進、佐藤智彦、荒井俊也、島辺宗健、黒川峰夫
- Organizer
  第68回日本癌学会学術総会
- Place of Presentation
  横浜
- Year and Date
  2009-10-01
- Data Source
  KAKENHI-PROJECT-20790669
[Presentation] Evi-1による造血幹細胞制御と白血病発症機構2009
- Author(s)
  合山進
- Organizer
  第5回麒麟塾
- Place of Presentation
  東京
- Year and Date
  2009-07-18
- Data Source
  KAKENHI-PROJECT-20790669
[Presentation] Function of Evi-1 as a leukemia-related transcription factor2009
- Author(s)
  合山進, 島辺宗健, 黒川峰夫
- Organizer
  USA-Japan Cooperative Cancer Workshop
- Place of Presentation
  Hawaii, U.S.A.
- Data Source
  KAKENHI-PROJECT-20790669
[Presentation] Evi-1による造血幹細胞制御と白血病発症機構2009
- Author(s)
  合山進
- Organizer
  第7回先端血液学セミナー
- Place of Presentation
  東京
- Year and Date
  2009-06-13
- Data Source
  KAKENHI-PROJECT-20790669
[Presentation] Evi-1による造血幹細胞制御と白血病発症機構2009
- Author(s)
  合山進
- Organizer
  第5回麟麟塾
- Place of Presentation
  東京
- Year and Date
  2009-07-18
- Data Source
  KAKENHI-PROJECT-20790669
[Presentation] EVI1 Represses PTEN Transcription and Activates AKT/mTOR Through Interaction with Polycomb Repressor complexes2009
- Author(s)
  吉見昭秀, 渡辺-大河内直子, 合山進, 南谷泰仁, 仁田英里子, 荒井俊也, 佐藤智彦, 島辺宗健, 中川正宏, 今井陽一, 北村俊雄, 黒川峰夫
- Organizer
  第71回日本血液学会総会
- Place of Presentation
  京都
- Year and Date
  2009-10-24
- Data Source
  KAKENHI-PROJECT-20790669
[Presentation] Evi-1 Is a Direct Target of MLL Oncoproteins in Hematopoietic Stem Cells.2008
- Author(s)
  荒井俊也, 合山進, 島辺宗健, 市川幹, 今井陽一, 高橋強志, 半下石明, 黒川峰夫
- Organizer
  50th American Society of Hematology Annnual Meeting.
- Place of Presentation
  San Francisco, U.S.A.
- Data Source
  KAKENHI-PROJECT-20790669
[Presentation] Evi-1 Is a Direct Target of MLL Oncoproteins in Hematopoietic Stem Cells2008
- Author(s)
  Arai S, Goyama S, Shimabe M, Ichikawa M, Imai Y, Takahashi T, Hangaishi A, Kurokawa M.
- Organizer
  50th American Society of Hematology Annnual Meeting
- Place of Presentation
  San Francisco, U.S.A.
- Year and Date
  2008-12-09
- Data Source
  KAKENHI-PROJECT-20790669
[Presentation] MLL融合遺伝子によるEvi-1の発現制御機構2008
- Author(s)
  荒井俊也、合山進、島辺宗健、市川幹、今井陽一、高橋強志、半下石明、黒川峰夫
- Organizer
  第70回日本血液学会総会
- Place of Presentation
  京都
- Year and Date
  2008-10-11
- Data Source
  KAKENHI-PROJECT-20790669
[Presentation] 白血病標的遺伝子Evi-1によるPBX-1の発現制御機構2008
- Author(s)
  島辺宗健、合山進、市川幹、今井陽一、高橋強志、半下石明、黒川峰夫
- Organizer
  第70回日本血液学会総会
- Place of Presentation
  京都
- Year and Date
  2008-10-11
- Data Source
  KAKENHI-PROJECT-20790669
[Presentation] Regulation of hematopoietic stem cell activity and leukemogenesis by AML12008
- Author(s)
  西本菜穂子、市川幹、中川正弘、合山進、高橋強志、今井陽一、黒川峰夫
- Organizer
  第67回日本癌学会学術総会
- Place of Presentation
  名古屋
- Year and Date
  2008-10-28
- Data Source
  KAKENHI-PROJECT-20790669
[Presentation] Evi-1による胎生期造血の制御機構2008
- Author(s)
  佐藤智彦, 合山進, 黒川峰夫
- Organizer
  第31回日本分子生物学会年会・第81回日本生化学会大会合同大会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-20790669
[Presentation] Evi-1 Interacts with Histone Methyltransferases for Transcription Repression and Bone Marrow Transformation.2008
- Author(s)
  合山進, 仁田英理子, 島辺宗健, 吉野哲也, 賀古真一, 市川幹, 今井陽一, 高橋強志, 半下石明, 黒川峰夫
- Organizer
  50th American Society of Hematology Annnual Meeting.
- Place of Presentation
  San Francisco, U.S.A.
- Data Source
  KAKENHI-PROJECT-20790669
[Presentation] Pbx-1 Is a Direct Target of Evi-1 in Hematopoietic Stem/Progenitors and Leukemic Cells2008
- Author(s)
  Shimabe M, Goyama S, Ichikawa M, Imai Y, Takahashi T, Hangaishi A, Kurokawa M.
- Organizer
  50th American Society of Hematology Annnual Meeting
- Place of Presentation
  San Francisco, U.S.A.
- Year and Date
  2008-12-07
- Data Source
  KAKENHI-PROJECT-20790669
[Presentation] Evi-1 up-regulates transcription of the PBX-1 gene in hematopoietic cells.2008
- Author(s)
  島辺宗健、合山進、市川幹、今井陽一、高橋強志、半下石明、黒川峰夫
- Organizer
  第67回日本癌学会学術総会
- Place of Presentation
  名古屋
- Year and Date
  2008-10-28
- Data Source
  KAKENHI-PROJECT-20790669
[Presentation] Evi-1 is a critical regulator for hematopoietic stem cells and leukemic cells.2008
- Author(s)
  Goyama S, Yamamoto G, Shimabe M, Sato T, Ichikawa M, Ogawa S, Chiba S, Kurokawa M.
- Organizer
  Keystone Symposium
- Place of Presentation
  Vancouver
- Year and Date
  2008-02-28
- Data Source
  KAKENHI-PROJECT-18890058
[Presentation] MLL融合遺伝子によるEvi-1の発現制御機構2008
- Author(s)
  荒井俊也、合山進、島辺宗健、市川幹、今井陽一、高橋強志、半下石明、黒川峰夫
- Organizer
  第67回日本癌学会学術総会
- Place of Presentation
  名古屋
- Year and Date
  2008-10-28
- Data Source
  KAKENHI-PROJECT-20790669
[Presentation] Pbx-1 Is a Direct Target of Evi-1 in Hematopoietic Stem/Progenitors and Leukemic Cells.2008
- Author(s)
  島辺宗健, 合山進, 市川幹, 今井陽一, 高橋強志, 半下石明, 黒川峰夫
- Organizer
  50th American Society of Hematology Annnual Meeting.
- Place of Presentation
  Francisco, U.S.A.
- Data Source
  KAKENHI-PROJECT-20790669
[Presentation] Functional and physical interaction between oncogenic transcriptional factor Evi-1 and histone methyltransferases.2008
- Author(s)
  合山進、仁田英理子、島辺宗健、市川幹、今井陽一、高橋強志、半下石明、黒川峰夫
- Organizer
  第67回日本癌学会学術総会
- Place of Presentation
  名古屋
- Year and Date
  2008-10-28
- Data Source
  KAKENHI-PROJECT-20790669
[Presentation] Evi-1 Interacts with Histone Methyltransferases for Transcription Repression and Bone. Marrow Transformation2008
- Author(s)
  Goyama S, Nitta E, Shimabe M, Yoshino T, Kako S, Ichikawa M, Imai Y, Takahashi T, Hangaishi A, Kurokawa M
- Organizer
  50th American Society of Hematology Annnual Meeting
- Place of Presentation
  San Francisco, U.S.A.
- Year and Date
  2008-12-08
- Data Source
  KAKENHI-PROJECT-20790669
[Presentation] Evi-1によるヒストンメチル化修飾異常を介した白血病発症機構.2008
- Author(s)
  合山進、黒川峰夫
- Organizer
  第12回がん分子標的治療研究会学術総会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-20790669
[Presentation] 白血病標的遺伝子Evi-1によるヒストンメチル化修飾を介した転写制御機構2008
- Author(s)
  合山進、仁田英里子、島辺宗健、吉野哲也、市川幹、今井陽一、高橋強志、黒川峰夫
- Organizer
  第70回日本血液学会総会
- Place of Presentation
  京都
- Year and Date
  2008-10-11
- Data Source
  KAKENHI-PROJECT-20790669
[Presentation] 白血病標的遺伝子Evi-1によるPBX-1の発現制御機構2008
- Author(s)
  島辺宗健、合山進、市川幹、今井陽一、高橋強志、半下石明、黒川峰夫
- Organizer
  第67回日本癌学会学術総会
- Place of Presentation
  名古屋
- Year and Date
  2008-10-28
- Data Source
  KAKENHI-PROJECT-20790669
[Presentation] Evi-1 is up-regulated by MLL oncoproteins selectively in hematopoietic cells.2008
- Author(s)
  荒井俊也、合山進、島辺宗健、市川幹、今井陽一、高橋強志、半下石明、黒川峰夫
- Organizer
  第67回日本癌学会学術総会
- Place of Presentation
  名古屋
- Year and Date
  2008-10-28
- Data Source
  KAKENHI-PROJECT-20790669
[Presentation] 白血病標的遺伝子Evi-1によるヒストンメチル化修飾を介した転写制御機構2008
- Author(s)
  合山進、仁田英理子、島辺宗健、市川幹、今井陽一、高橋強志、半下石明、黒川峰夫
- Organizer
  第67回日本癌学会学術総会
- Place of Presentation
  名古屋
- Year and Date
  2008-10-28
- Data Source
  KAKENHI-PROJECT-20790669

1. Kitamura Toshio (20282527)

# of Collaborated Projects: 4 results

# of Collaborated Products: 20 results
2. Mori Tsutomu (60244373)

# of Collaborated Projects: 3 results

# of Collaborated Products: 3 results
3. 長門石曉 (30550248)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. 高橋宏隆 (70432804)

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
5. 山本圭太 (70899301)

# of Collaborated Projects: 2 results

# of Collaborated Products: 8 results
6. KUROKAWA Mineo (80312320)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
7. HANGAISHI Akira (20344450)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. IZUTSU Koji (30361471)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
9. 坂本毅治 (70511418)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 池田和彦 (90381392)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 高木正稔 (10406267)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 程久美子 (50213327)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 今井陽一 (10345209)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
14. Hayashi Yasutaka

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
15. Saika Makoto

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. Yonezawa Taishi

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. Liu XiaoXiao

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
18. KAWAMURA Takashi

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. YAMAGUCHI Kiyoshi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
20. 深川竜郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
21. 井上大地

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
22. 広瀬哲郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Goyama Susumu 合山 進

GOYAMA Susumu 合山 進

Research Projects

Research Products

Co-Researchers

Development of In Vivo Gene Therapy for Bone Marrow Failure SyndromePrincipal Investigator

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Comprehensive identification of immune checkpoints in hematopoietic tumors using Ab initio genetic orbital method

Principal Investigator

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DNAM-1/TIGIT/CD155/CD112を標的としたAMLに対する免疫療法の開発

Principal Investigator

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Review Section

Research Institution

Analyses of biological roles and significance of nuclear paraspeckles, formed by LLPS, liquid-liquid phase separation

Principal Investigator

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Review Section

Research Institution

Identification of the cell of origin of infant leukemia with pluripotencyPrincipal Investigator

Principal Investigator

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Review Section

Research Institution

Development of RNA-targeting drugs for hematopoietic neoplasmsPrincipal Investigator

Principal Investigator

Project Period (FY)

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Review Section

Research Institution

Identification of tumor driver lncRNAs in myeloid tumors and development of lncRNA-targeting therapiesPrincipal Investigator

Principal Investigator

Project Period (FY)

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Review Section

Research Institution

Development of proteostasis modulators targeting the co-chaperon E3 ligase STUB1Principal Investigator

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Integrated functional analysis of lncRNAs in hematopoietic tumors using the Ab initio method

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Crosstalk between clonal hematopoiesis and solid tumorsPrincipal Investigator

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Targeting transcription and epigenetic factors through modulation of protein-protein interactionsPrincipal Investigator

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Analyses of relationship between clonal hematopoiesis associated with leukemia-related gene mutations and leukemia/solid tumors/cardiovascular diseases

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Ab initio analysis on the pathophysiology of hematopoietic neoplasms

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Goyama Susumu 合山進

GOYAMA Susumu 合山進