Nojima Takayuki 野島孝之

… Alternative Names

NOJIMA Takayuki 野島孝之

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Researcher Number	80431956
Other IDs	https://orcid.org/0000-0003-1236-4162
Affiliation (Current)	2026: 横浜市立大学, 医学研究科, 教授
Affiliation (based on the past Project Information) *help	2026: 九州大学, 生体防御医学研究所, 准教授 2021 – 2024: 九州大学, 生体防御医学研究所, 准教授 2010: Tokyo Medical and Dental University, その他 2008 – 2009: Tokyo Medical and Dental University, 大学院・疾患生命科学研究部, 特任助教 2007: 東京医科歯科大学, 難治疾患研究所, 特任助教
Review Section/Research Field	Principal Investigator Transformative Research Areas, Section (III) / Basic Section 43010:Molecular biology-related / Biological Sciences / Biological pharmacy / Virology Except Principal Investigator Basic Section 43050:Genome biology-related / Medium-sized Section 50:Oncology and related fields / General medical chemistry / Biological Sciences
Keywords	Principal Investigator RNAポリメラーゼII / RNAプロセシング / 転写終結 / 新生RNA / DNA損傷 / クロマチン環境 / 転写スピード / 細胞ストレス / 非コードRNA / エピジェネティクス … More / ゲノム転写 / RNA プロセシング / クロマチン / RNA polymerase II / レポーター / 蛍光タンパク質 / ピルビン酸キナーゼ(PKM) / RNA選択的スプライシング / 悪性腫瘍 / Pre-mRNA / ミニ遺伝子 / スプライシングアイソフォーム / Pre-Mrna / ICP27 / 前骨髄球性白血病(PML)遺伝子 / 選択的スプライシング / 単純ヘルペスウイルス … More Except Principal Investigator ICP27 / 転写/複製コンフリクト / RNAポリメラーゼ / DNAポリメラーゼ / ゲノム安定性 / 転写・複製コンフリクト / 転写 / DNA複製 / DNA損傷応答 / 免疫治療 / 転写異常 / 翻訳異常 / HLA Class I / ゲノム変異非依存的 / ネオアンチゲン / DNA損傷 / 核外輸送 / EJC / イントロンレスmRNA / キャップ構造 / UAP56 / mRNA核外輸送 / SRPK / 核外油症 / mRNA / REF / CBC / 選択的スプライシング / PML / 単純ヘルペスウイルス Less

タンパク質コード遺伝子に埋め込まれた非コード攪乱RNAの産生機構と細胞機能Principal Investigator
- Principal Investigator
  
  野島孝之
- Project Period (FY)
  2026 – 2027
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (A)
- Review Section
  
  Transformative Research Areas, Section (III)
- Research Institution
  Kyushu University
DNA複製・RNA転写コンフリクトのゲノム科学的解析
- Principal Investigator
  
  大学保一
- Project Period (FY)
  2024 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 43050:Genome biology-related
- Research Institution
  Japanese Foundation for Cancer Research
Mechanism of transcription termination defect caused by cellular stressesPrincipal Investigator
- Principal Investigator
  
  野島孝之
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 43010:Molecular biology-related
- Research Institution
  Kyushu University
Elucidation of the mechanisms underlying neoantigen production independent of genomic mutation induced by DNA damage
- Principal Investigator
  
  柴田淳史
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 50:Oncology and related fields
- Research Institution
  Keio University
Mechanism of transcription coupled to RNA processing and its defectPrincipal Investigator
- Principal Investigator
  
  Nojima Takayuki
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Fund for the Promotion of Joint International Research (Home-Returning Researcher Development Research)
- Review Section
  
  Biological Sciences
- Research Institution
  Kyushu University
悪性腫瘍特異的なRNA選択的スプライシングを制御する抗がん剤の開発Principal Investigator
- Principal Investigator
  
  野島孝之
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research a proposed research project)
- Research Field
  
  Biological pharmacy
- Research Institution
  Tokyo Medical and Dental University
Regulation of host-alternative splicing in herpesvirus-infectedPrincipal Investigator
- Principal Investigator
  
  NOJIMA Takayuki
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Virology
- Research Institution
  Tokyo Medical and Dental University
ヘルペスウイルスRNAの核外輸送制御機構の解明
- Principal Investigator
  
  HAGIWARA Masatoshi
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Tokyo Medical and Dental University
Molecular Mechanism of Inronless mRNA transport
- Principal Investigator
  
  HAGIWARA Masatoshi
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General medical chemistry
- Research Institution
  Tokyo Medical and Dental University

All 2025 2024 2023 2022 2021 2010 2009 2008 2007

All Journal Article Presentation Book

[Book] “情報”から“マテリアル”へ　ノンコーディングRNA研究2024
- Author(s)
  中山千尋、野島孝之
- Total Pages
  8
- Publisher
  実験医学
- Data Source
  KAKENHI-PROJECT-24K01957
[Book] RNAスプライシングの可視化による創薬スクリーニング2010
- Author(s)
  野島孝之, 萩原正敏
- Total Pages
  7
- Publisher
  秀潤社
- Data Source
  KAKENHI-PROJECT-20790353
[Book] 細胞工学(特集)RNAスプライシングの可視化による創薬スクリーニング2010
- Author(s)
  野島孝之
- Total Pages
  7
- Publisher
  秀潤社
- Data Source
  KAKENHI-PROJECT-21200074
[Book] 細胞工学(特集)RNAスプライシングの可視化による創薬スクリーニング2010
- Author(s)
  野島孝之
- Total Pages
  7
- Publisher
  秀潤社
- Data Source
  KAKENHI-PROJECT-20790353
[Book] 実験医学(増刊)ウイルスによるスプライシング暗号の利用と撹乱2009
- Author(s)
  野島孝之
- Total Pages
  6
- Publisher
  羊土社
- Data Source
  KAKENHI-PROJECT-21200074
[Book] 実験医学(増刊)ウイルスによるスプライシング暗号の利用と撹乱2009
- Author(s)
  野島孝之
- Total Pages
  6
- Publisher
  羊土社
- Data Source
  KAKENHI-PROJECT-20790353
[Book] ウイルスによるスプライシング暗号の利用と撹乱2009
- Author(s)
  野島孝之, 萩原正敏
- Total Pages
  6
- Publisher
  羊土社
- Data Source
  KAKENHI-PROJECT-20790353
[Journal Article] NELF coordinates Pol II transcription termination and DNA replication initiation2024
- Author(s)
  Nakayama Chihiro、Daigaku Yasukazu、Aoi Yuki、Fang Qi、Kimura Hiroshi、Shilatifard Ali、Tellier Michael、Nojima Takayuki
- Journal Title
  
  BioRxiv
  
  Volume: NA
- DOI
  10.1101/2024.01.31.578294
- Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K24692, KAKENHI-PROJECT-23K27156
[Journal Article] DNA-directed termination of mammalian RNA polymerase II2024
- Author(s)
  Davidson Lee、Rouviere Jerome O.、Sousa-Luis Rui、Nojima Takayuki、Proudfoot Nicholas J.、Jensen Torben Heick、West Steven
- Journal Title
  
  Genes & Development
  
  Volume: 38 Issue: 21-24 Pages: 998-1019
- DOI
  10.1101/gad.351978.124
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-24K01957
[Journal Article] Defining gene ends: RNA polymerase II CTD threonine 4 phosphorylation marks transcription termination regions genome-wide2024
- Author(s)
  Kopczy?ska Magda、Saha Upasana、Romanenko Anastasiia、Nojima Takayuki、Gdula Micha??R、Kamieniarz-Gdula Kinga
- Journal Title
  
  Nucleic Acids Research
  
  Volume: 53 Issue: 2 Pages: 1-17
- DOI
  10.1093/nar/gkae1240
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-24K01957
[Journal Article] PTBP1-activated co-transcriptional splicing controls epigenetic status of pluripotent stem cells2023
- Author(s)
  Iannone Camilla、Kainov Yaroslav、Zhuravskaya Anna、Hamid Fursham、Nojima Takayuki、Makeyev Eugene V.
- Journal Title
  
  Molecular Cell
  
  Volume: 83 Issue: 2 Pages: 203-218.e9
- DOI
  10.1016/j.molcel.2022.12.014
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K24692
[Journal Article] <scp>CDK9</scp> and <scp>PP2A</scp> regulate <scp>RNA</scp> polymerase <scp>II</scp> transcription termination and coupled <scp>RNA</scp> maturation2022
- Author(s)
  Tellier Michael、Zaborowska Justyna、Neve Jonathan、Nojima Takayuki、Hester Svenja、Fournier Marjorie、Furger Andre、Murphy Shona
- Journal Title
  
  EMBO reports
  
  Volume: 23 Issue: 10 Pages: 1-22
- DOI
  10.15252/embr.202154520
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K24692
[Journal Article] Ptbp1-Activateded Co-Transcriptional Splicing Controls Epigenetic Status of Pluripotent Stem Cells2022
- Author(s)
  Iannone C, Yaroslav K, Anna Z , Fursham H, Nojima T and Makeyev EV
- Journal Title
  
  Cell Press Sneak Peek, preprint
  
  Volume: -
- DOI
  10.2139/ssrn.4058691
- Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K24692
[Journal Article] Mechanism of lncRNA biogenesis as revealed by nascent transcriptomics2022
- Author(s)
  Nojima T and Proudfoot NJ
- Journal Title
  
  Nature Reviews Molecular Cell Biology
  
  Volume: - Issue: 6 Pages: 1-18
- DOI
  10.1038/s41580-021-00447-6
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K24692
[Journal Article] CDK9 and PPA2 regulate the link between RNA polymerase II transcription termination and RNA maturation2021
- Author(s)
  1.Tellier M, Zaborowska J, Neve J, Nojima T, Hester S, Furger A, and Murphy S
- Journal Title
  
  bioRxiv
  
  Volume: -
- DOI
  10.1101/2021.06.21.449289
- Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K24692
[Journal Article] Simultaneous studies of gene expression and alternative polyadenylation in primary human immune cells2021
- Author(s)
  Wilton J, Tellier M, Nojima T, Costa AM, Oliveira MJ, and Moreira A
- Journal Title
  
  Methods in Enzymology
  
  Volume: 655 Pages: 349-399
- DOI
  10.1016/bs.mie.2021.04.004
- ISBN
  9780128235737
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K24692
[Journal Article] RNAスプライシングの可視化による創薬スクリーニング2010
- Author(s)
  野島孝之, 萩原正敏
- Journal Title
  
  細胞工学 Vol.29, No.2
- Data Source
  KAKENHI-PROJECT-19390071
[Journal Article] Herpesvirus protein ICP27 switches PML isoform by altering mRNA splicing2009
- Author(s)
  Takayuki Nojima
- Journal Title
  
  Nucleic Acids Research 37
  
  Pages: 6515-6527
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790353
[Journal Article] Herpesvirus protcin ICP27 switches PML-isoform by altering mRNA splicing Nucleic2009
- Author(s)
  Nojima T, Oshiro-Ideue T, Nakanoya H, Kawamura H, Morimo to M.Kawaguchi Y, Kataoka N, Hagiwara M
- Journal Title
  
  Acids Res 37(19)
  
  Pages: 6515-27
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390071
[Journal Article] ウイルスによるスプライシング暗号の利用と撹乱2009
- Author(s)
  萩原正敏, 野島孝之
- Journal Title
  
  実験医学増刊 Vol.27, No.10
- Data Source
  KAKENHI-PROJECT-19390071
[Journal Article] Herpesvirus protein ICP27 switches PML isoform by altering mRNA splicing2009
- Author(s)
  Takayuki Nojima
- Journal Title
  
  Nucleic Acids Research 37
  
  Pages: 6515-6527
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21200074
[Journal Article] ウイルスによるスブライシング暗号の利用と撹乱2009
- Author(s)
  萩原正敏、野島孝之
- Journal Title
  
  実験医学 27(10)
  
  Pages: 42-47
- Data Source
  KAKENHI-PROJECT-19390071
[Journal Article] Herpesvirus protein ICP27 switches PML isoform by altering mRNA splicing2009
- Author(s)
  Nojima T, Oshiro-Ideue T, Nakanoya H, Kawamura H, Morimoto M, Kawaguchi Y, Kataoka N, Hagiwara M
- Journal Title
  
  Nucleic.Acids Res. 37(19)
  
  Pages: 6515-27
- Data Source
  KAKENHI-PROJECT-19390071
[Journal Article] Herpesvirus protein ICP27 switches PML isoform by altering mRNA splicing2009
- Author(s)
  Nojima T, Oshiro-Ideue T, Nakanoya T, Kawamura H, Morimoto T, Kawaguchi Y, Kataoka N, Hagiwara M
- Journal Title
  
  Nucleic Acids Research 37
  
  Pages: 6515-6527
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790353
[Journal Article] The interaction between cap-binding complex and REF is req uired for intronless mRNA export.2007
- Author(s)
  Nojima, T
- Journal Title
  
  J. Biol. Chem. 282
  
  Pages: 15645-1565
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19041027
[Journal Article] The interaction between cap-binding complex and REF is required for intronless mRNA export.2007
- Author(s)
  Nojima, T
- Journal Title
  
  J. Biol. Chem. 282
  
  Pages: 15645-15651
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390071
[Presentation] Pol II 転写サイクル制御の分子機構2025
- Author(s)
  野島孝之
- Organizer
  第1回転写研究会
- Invited
- Data Source
  KAKENHI-PROJECT-24K01957
[Presentation] Ending RNA messages in cancer cells2024
- Author(s)
  野島孝之
- Organizer
  公益財団法人がん研究会がん研セミナー
- Invited
- Data Source
  KAKENHI-PROJECT-19K24692
[Presentation] Ending Pol II transcription in cancer2024
- Author(s)
  Takayuki Nojima
- Organizer
  第47回日本分子生物学会（オーストラリア分子生物学会合同企画）
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-24K01957
[Presentation] NELF promotes transcription termination and cell cycle2024
- Author(s)
  Takayuki Nojima
- Organizer
  3R +3C
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-24K01957
[Presentation] NELF coordinates Pol II transcription termination and DNA replication initiation2024
- Author(s)
  Takayuki Nojima
- Organizer
  International RNA society annual meeting 2024
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-24K01957
[Presentation] 出来立てのRNAを調べてわかるゲノム作動2024
- Author(s)
  野島孝之
- Organizer
  慶應薬学サイヤンスセミナー
- Invited
- Data Source
  KAKENHI-PROJECT-19K24692
[Presentation] Catch RNA polymerase II in transcription cycle2023
- Author(s)
  野島孝之
- Organizer
  第35回 Tokyo RNA Club
- Invited
- Data Source
  KAKENHI-PROJECT-19K24692
[Presentation] 新生 RNA 解析から理解するゲノム転写サイクル制御2023
- Author(s)
  野島孝之
- Organizer
  第6回サテライトシンポジウム」―RNA が制御する多様な生命機能―
- Invited
- Data Source
  KAKENHI-PROJECT-19K24692
[Presentation] リードスルーRNA転写による細胞周期の停止2023
- Author(s)
  野島孝之
- Organizer
  日本生化学会
- Invited
- Data Source
  KAKENHI-PROJECT-19K24692
[Presentation] NELF restricts deleterious readthrough RNAs in replicating cells2023
- Author(s)
  野島孝之
- Organizer
  日本RNA学会
- Data Source
  KAKENHI-PROJECT-19K24692
[Presentation] 転写終結による RNA転写とDNA複製の棲み分け2023
- Author(s)
  野島孝之
- Organizer
  日本分子生物学会
- Invited
- Data Source
  KAKENHI-PROJECT-19K24692
[Presentation] 新生RNA解析で理解するゲノム作動2022
- Author(s)
  野島孝之
- Organizer
  国立遺伝学研究所研究会　染色体安定維持研究会
- Invited
- Data Source
  KAKENHI-PROJECT-19K24692
[Presentation] 新生RNAエンド2022
- Author(s)
  野島孝之
- Organizer
  RNAフロンティアミーティング2022
- Invited
- Data Source
  KAKENHI-PROJECT-19K24692
[Presentation] Transcription termination: Forgotten mechanism in RNA synthesis cycle2022
- Author(s)
  野島孝之
- Organizer
  熊本大学リエゾンラボ/HIGO最先端研究セミナー
- Invited
- Data Source
  KAKENHI-PROJECT-19K24692
[Presentation] POINting toward transcription termination2022
- Author(s)
  Takayuki Nojima
- Organizer
  Hot spring harbour symposium、クロマチン潜在能合同国際シンポジウム
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K24692
[Presentation] Mechanism of Co-transcriptional RNA splicing2021
- Author(s)
  Takayuki Nojima
- Organizer
  生命科学ネットワークシンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-19K24692
[Presentation] End of RNA synthesis2021
- Author(s)
  Takayuki Nojima
- Organizer
  第94回日本生化学会ジェットラグシンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-19K24692
[Presentation] HSV-2増殖に関わるPMLアイソフォーム発現制御2009
- Author(s)
  野島孝之
- Organizer
  第82回日本生化学会
- Place of Presentation
  神戸ポートアイランド
- Year and Date
  2009-10-21
- Data Source
  KAKENHI-PROJECT-21200074
[Presentation] Herpesvirus protein ICP27 switches PML isoform by altering mRNA splicing2009
- Author(s)
  野島孝之
- Organizer
  RNA meeting 2009
- Place of Presentation
  Wisconsin University, USA
- Year and Date
  2009-05-26
- Data Source
  KAKENHI-PROJECT-21200074
[Presentation] HSV-2増殖に関わるPMLアイソフォーム発現制御2009
- Author(s)
  野島孝之
- Organizer
  第82回日本生化学会
- Place of Presentation
  神戸ポートアイランド
- Year and Date
  2009-10-21
- Data Source
  KAKENHI-PROJECT-20790353
[Presentation] Herpesvirus protein ICP27 switches PAM isoform by altering mRNA splicing2009
- Author(s)
  野島孝之
- Organizer
  RNA meeting 2009
- Place of Presentation
  Wisconsin University, USA
- Year and Date
  2009-05-26
- Data Source
  KAKENHI-PROJECT-20790353
[Presentation] Herpesvirus protein ICP27 switches PML isoform by altering mRNA Splicing2009
- Author(s)
  Takayuki Nojima
- Organizer
  RNA meeting 2009
- Place of Presentation
  Wisconsin University, USA
- Year and Date
  2009-05-26
- Data Source
  KAKENHI-PROJECT-20790353
[Presentation] ウイルス感染が引き起こすPMLアイソフォームの切り換え2008
- Author(s)
  野島孝之
- Organizer
  第10回日本RNAミーティング
- Place of Presentation
  札幌コンベンションセンター
- Year and Date
  2008-07-23
- Data Source
  KAKENHI-PROJECT-20790353
[Presentation] ウイルス感染が引き起こすPMLアイソフォームの切り換え2008
- Author(s)
  野島孝之
- Organizer
  第10回日本RNAミーティング
- Place of Presentation
  札幌コンベンションセンター
- Year and Date
  2008-07-23
- Data Source
  KAKENHI-PROJECT-20790353
[Presentation] Interference of host mRNA metabolisms by Herpes simplex virus type 22007
- Author(s)
  野島孝之
- Organizer
  第7回あわじしま感染症・免疫フォーラム
- Place of Presentation
  淡路夢舞台国際会議場
- Year and Date
  2007-09-03
- Data Source
  KAKENHI-PROJECT-19041027
[Presentation] 単純ヘルペスウイルスRNAの核外輸送制御機構の解明2007
- Author(s)
  野島孝之
- Organizer
  第4回ウィルス学キャンプ
- Place of Presentation
  ウェルシティ湯河原
- Data Source
  KAKENHI-PROJECT-19041027

1. HAGIWARA Masatoshi (10208423)

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
2. 小野木博 (50384871)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 柴田淳史 (30707633)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 大学保一 (80619875)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Nojima Takayuki 野島 孝之

NOJIMA Takayuki 野島 孝之

Research Projects

Research Products

Co-Researchers

タンパク質コード遺伝子に埋め込まれた非コード攪乱RNAの産生機構と細胞機能Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

DNA複製・RNA転写コンフリクトのゲノム科学的解析

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Mechanism of transcription termination defect caused by cellular stressesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of the mechanisms underlying neoantigen production independent of genomic mutation induced by DNA damage

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Mechanism of transcription coupled to RNA processing and its defectPrincipal Investigator

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Regulation of host-alternative splicing in herpesvirus-infectedPrincipal Investigator

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ヘルペスウイルスRNAの核外輸送制御機構の解明

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Molecular Mechanism of Inronless mRNA transport

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[Book] “情報”から“マテリアル”へ ノンコーディングRNA研究2024

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[Book] RNAスプライシングの可視化による創薬スクリーニング2010

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[Book] 細胞工学(特集)RNAスプライシングの可視化による創薬スクリーニング2010

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[Book] 細胞工学(特集)RNAスプライシングの可視化による創薬スクリーニング2010

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[Book] 実験医学(増刊)ウイルスによるスプライシング暗号の利用と撹乱2009

Nojima Takayuki 野島孝之

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[Book] “情報”から“マテリアル”へ　ノンコーディングRNA研究2024