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Hagiwara Masatoshi  萩原 正敏

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… Alternative Names

HAGIWARA Masatoshi  萩原 正敏

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Researcher Number 10208423
Other IDs
External Links
Affiliation (Current) 2024: 京都大学, 医学研究科, 教授
Affiliation (based on the past Project Information) *help 2015 – 2024: 京都大学, 医学研究科, 教授
2015: 京都大学, 大学院医学研究科, 教授
2011 – 2015: 京都大学, 医学(系)研究科(研究院), 教授
2012: 京都大学, 医学研究科形態形成機構学, 講座
2011: 京都大学, 大学院・医学研究科, 教授 … More
2010: 京都大学, 医学研究科, 教授
2009: 東京医科歯科大学, 大学院・疾患生命科学研究部, 非常勤講師
2003 – 2008: 東京医科歯科大学, 大学院・疾患生命科学研究部, 教授
2005 – 2006: Tokyo Medical and Dental University, School of Biocemical Science, Professor, 大学院疾患生命科学研究部, 教授
2003: HAGIWARA,Masatoshi, 大学院・疾患生命科学研究所, 教授
1996 – 2002: Medical Research Institute, Tokyo Medical and Dental University, Professor, 難治疾患研究所, 教授
1998: 東京医科歯科大, 難治研, 教授
1998: 東京医科歯科大学, 難治疾患研究所
1996: 東京医科歯科大学, 医学部, 教授
1996: TOKYO MEDICAL DENTAL COLLEGE. ASSOCIATE PROFESSOR, 難治疾患研究所, 助教授
1996: Tokyo Medical and Dental University Medical Research Institute Professor, 難治研, 教授
1995 – 1996: 名古屋大学, 医学部, 助教授
1993 – 1995: 名古屋大学, 医学部, 講師
1988 – 1992: Nagoya University School of Medicine, Staff, 医学部, 助手 Less
Review Section/Research Field
Principal Investigator
Biological Sciences / General medical chemistry / General pharmacology / General medical chemistry / General pharmacology / Broad Section H / Chemical biology / Molecular biology / Functional biochemistry / Pathological medical chemistry / Chemical biology / Living organism molecular science / Cell biology … More
Except Principal Investigator
… More Biological Sciences / General pharmacology / Basic Section 56030:Urology-related / Pain science / 物質生物化学 / Digestive surgery / Cerebral neurosurgery / 代謝生物化学 / Pathological medical chemistry / ケミカルバイオロジー / Neuroscience in general Less
Keywords
Principal Investigator
CREB / SRPK / Clk / スプライシング / 選択的スプライシング / alternative splicing / mRNA / SF2 / ATF1 / CBP … More / REF / GFP / ASF / 長期記憶 / ドミナントネガティブ / iPS / CRISPR / CLASP / SR蛋白質 / 特異的阻害剤 / mRNAプロセシング / 蛋白リン酸化酵素阻害剤 / Sty / Clk1 / SRタンパク質 / インシュリン / SRPIN340 / 転写 / SF1-U2AF / Aly / RNAi / Dymple / ZF5 / SPOP / MKK6 / Phosphorylation / リン酸化 / リン酸化酵素 / 核外輸送 / EJC / ICP27 / 発現制御 / E1A / 神経発生 / ターゲット遺伝子 / Aキナーゼ / cAMP / RNAプロセシング / 液－液相分離 / RNA結合蚕白質 / 病的液-液相分離 / RNA ポリメラーゼII / SRタンパク / 病的液-液相分 / kibans / トランスクリプトーム / RNA病モデル / モデルトランスクリプトーム解析 / トランスクリプトーム解析 / RNA病 / スプライシング介入ルール / 遺伝子性疾患 / ポストゲノム創薬 / スプライシング制御 / 遺伝性疾患 / 創薬 / virus / TG003 / 4 / 抗ウイルス薬 / ウイルス / protein kinase inhibitor / mRNA processing / SR proteins / プロテインキナーゼ阻害剤 / ClK / CBP20 / mRNA export / Alternative splicing / RS蛋白 / mRNA輸送 / RSドメイン / U2AF / RNA結合蛋白質 / SF1-U2AF複合体 / 構成的スプライシング / cellular codes / エキソンスキッピング / スプライシング共役系 / asd-1 / 温度感受性変異株 / スプライシングコード / phosphorylation of SR proteins / arginine methylation / リン酸化反応 / RT-PCR / カルシトニン / SR蛋白リン酸化 / アルギニンメチル / immunoscreening / auto antigen / HOG / P38 / TAK1 / Behcet病 / 核内蛋白 / 自己抗体 / Mitosin / Ki67 / 抗体スクリーニング / 自己抗原 / CREB結合蛋白 / 蛋白リン酸化 / 転写調節 / phosphorylation / ハイスループット / 低分子化合物 / DYRK1A / 細胞 / ストレス / FTDP-17 / アルツハイマー / 神経変性疾患 / 急性ストレス / タウ / スクリーニング / 化合物 / アルツハイマー病 / タウオパチー / 発現パターン / 大脳皮質 / プロファイリング解析 / スプライシング調節因子 / エクソンアレイ / 大脳皮質形成 / イントロンレスmRNA / キャップ構造 / UAP56 / mRNA核外輸送 / 核外油症 / CBC / PML / 単純ヘルペスウイルス / アフィニティ磁性ナノビーズ / PETプローブ / バイオイメージングプローブ / リン酸化酵素阻害剤 / 疾患ケミカルバイオロジー / ケミカルジェネティクス / ケミカルバイオロジー / バーチャルリアリティ / 生体生命情報学 / シミュレーション工学 / 神経科学 / 行動学 / 言語学習 / 遺伝子 / Biobje / 遺伝情報プログラム / シミュレーション / グルタミン酸受容体 / 歌学習 / キンカチョウ / 線虫 / RNA結合蛋白 / PARP / caspase / apoptosis / splicing / KID / CAMP / speckled patterm / mRNAファクトリー / prox1 / シナプス可塑性 / CRE / 増殖関連遺伝子 / PC12細胞 / RL-ATF1 / dual-specific phosphatase / E-カドヘリン / リン酸化制御 / MAPKK6 / Bridging Factors / 核内局在 / CaMキナーゼ / カルモジュリン / グリオーマ / アンチセンス / CD44 / 接着分子 / AFT1 / cdc2 kinase / 細胞周期依存的リン酸化反応 / アダプター因子 / 副甲状腺 / CaM依存性蛋白質キナ-ゼ / Ca^<2+> / カルシウム情報伝達系 … More
Except Principal Investigator
スプライシング / GFP / 低角度回転蒸着 / CREB / ML-9 / PDE / cGMP / Protein kinase / プロテインキナーゼ阻害剤 / Protein kinase C / 特異的阻害剤 / KN-62 / Protein phosphorylation / カルモデュリンキナ-ゼII / KNー62 / プロテインキナ-ゼ / 蛋白質リン酸化反応 / RNA結合タンパク質 / レポーター / キナーゼ阻害剤 / 阻害剤 / キナーゼ / 転写因子 / DNA / 原子間力顕微鏡 / イメージング / 転写調節因子 / エンザイムイムノアッセイ / Cキナ-ゼアイソザイム / 神経内分泌前立腺癌 / 去勢抵抗性前立腺癌 / エクソソーム / 致死性前立腺癌 / アミノ酸トランスポーター / カゼインキナーゼ1 / 霊長類疼痛モデル / ケミカルバイオロジー / カゼインキナーゼ 1 / 難治性疼痛 / Wntシグナル / vacuolar-ATPase / リン酸化酵素 / 脊髄 / 炎症性疼痛 / 神経障害性疼痛 / Affinity chromatography / Thyroxine / Myosin light chain kinase / サイロキシン / Aキナーゼ / Cキナーゼ / ミオシン軽鎖キナーゼ / アフィニティークロマトグラフ / transcriptional regulation / peritoneal dessemination / retroviral vector / gene therapy / off制御 / on / ドキシサイクリン / レトロウイルスベクター / 腹膜播種癌 / 遺伝子発現制御 / 腹膜播腫癌 / 発現ベクター / 遺伝子治療 / transfer activation / reorganization / transfer extension reaction / transcription initiation / functional mechanism / inter-transcriptional interaction / transcriptional cofactor / transcription factor / ノックアウトマウス / TF II H / TF II E / TF II D / コアクチベータ- / 基本転写装置 / STAT3 / Ah受容体 / DSIF / コアクチベーター / TFIID / TFIIE / TFIIH / 相互作用 / DNA結合能 / リン酸化 / 転写開始複合体 / 転写活性化 / 再構成 / 転写伸長反応 / 転写開始 / 作用機構 / 転写因子間相互作用 / 転写共役因子 / Structural analysis / Photoreception / Imaging / Photoreceptor cell / Low angle rotary shadowing / Phototransduction / 構造解析 / 光受容 / 視細胞 / 光情報伝達系 / SIGNAL TRANSDUCTION / PHOSPHORYLATION / NF-kappaB / LIPOSOME / GENE / TNF / INTERFERON / BRAIN TUMOR / NF-κB / シグナル伝達 / リン酸化蛋白 / NF-kB / リポソーム / 遺伝子 / 腫瘍壊死因子 / インターフェロン / 脳腫瘍 / Computer simulation / Drug design / Structure-activity relationship / Tertiary structure / Inhibitor / Intracellular signal transduction / 分子基礎理論 / 活性調節部位 / 有機合成 / 分子設計 / コンピューターシュミレーション / 創薬 / 蛋白質立体構造 / 構造活性相関 / 蛋白質リン酸化酵素 / 細胞内シグナリング / Calcium signal network / Calcium binding protein / EF-hand protein / Annexin / Calcium Signaling / カルシウム結合タンパク質 / EFーハンドタンパク質 / カルシウムシグナル / カルシウムシグナルネットワ-ク / カルシウム受容蛋白質 / EFーハンド蛋白質 / アネキシン / 新しいカルシウム情報伝達系 / Inhibitor Data Base / Protein Kinase Inhibitor / 阻害剤デ-タベ-ス / プロテインキナ-ゼ阻害剤 / 阻害剤データベース / プロテインキナーゼ / Protein kinase inhibitor / H-89 / EIA / CaM-kinase II / Ca^<2+>-dependent protein kinase / Cキナ-ゼアイソザイムの細胞特異的発現 / MARCKS / ACAMPー81 / GABA放出 / 長期増強現象 / ζ型Cキナ-ゼ / δ型Cキナ-ゼ / Aーキナ-ゼ / 蛋白質リン酸化酵素阻害剤 / Hー89 / 酵素抗体法 / Cーキナ-ゼ / カルシウム依存性蛋白質リン酸化酵素 / Protein Kinase / Ca^<2+> binding protein (s) / Myosin light chain phosphorylation / カルバスクリン / カルギザリン / カルシウム結合蛋白 / ミオシン脱リン酸化酵素 / Ca^<2+>結合蛋白質 / ミオシン軽鎖リン酸化反応 / 低分子化合物 / 筋ジストロフィー / ジストロフィン / 発生、分化 / 神経科学 / スプライス・サイト認識 / Fibroblast Growth Factor Receptor2 / スプライシング・レポーターマウス / スプライシング・レポーター / 組織特異的スプライシング制御 / 相互排他的スプライシング制御 / 選択的スプライシング制御 / (8)スプライス・サイト認識 / (7)RNA結合タンパク質 / (6)Fibroblast Growth Factor Receptor2 / (5)スプライシング・レポーターマウス / (4)スプライシング・レポーター / (3)組織特異的スプライシング制御 / (2)相互排他的スプライシング制御 / (1)選択的スプライシング制御 / RNAプロセッシング / 変異体 / 組織特異性 / 線虫 / 選択的スプライシング / SR / ウイルス / CMV / SARS / HIV / SRPK / 発現制御 / バーチャルリアリティ / 生体生命情報学 / シミュレーション工学 / DNAチップ / アロディニア / PGE_2 / リアノジン受容体 / 15R-TIC / リピドA / サリドマイド / Cu-ATSM / ダントロレン誘導体 / 4'-チオリボヌクレオシド / 可視化プローブ / RXRアンタゴニスト / プロスグランジン / 34mCl / レチノイド / 光親和性標識法 / MicroPET / プラナーポジトロンイメージング / 神経性疼痛 / Socius / ABCトランスポーター / non-RI光親和性標識法 / 3成分連結PG合成法 / シグナル解析 / 神経因性疼痛 / 人工核酸 / 蛍光プローブ / 高速メチル化 / PET / 転写制御 / 血管平滑筋 / cAMP / 蛍光カルシウム指示薬 / 受精 / 分泌 / 膵臓β細胞 / イノシトール三燐酸 / カルシウム / 大腸菌 / 電子顕微鏡 / RNAポリメラーゼ / 転写調節 / 低角度回転蒸着法 / Holiday Junction / CRP / 燐酸化 / 細胞増殖 Less

  • Research Projects

    (61 results)

  • Research Products

    (504 results)

  • Co-Researchers

    (102 People)

  •  A Comprehensive Amino Acid Transporter-Based Therapeutic Strategy for Lethal Prostate Cancer

    • Principal Investigator
      坂本 信一
    • Project Period (FY)
      2024 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 56030:Urology-related
    • Research Institution
      Chiba University

  •  Synthetic investigation of pathological phase separation of RNA-binding proteinsPrincipal Investigator

    • Principal Investigator
      萩原 正敏
    • Project Period (FY)
      2021 – 2025
    • Research Category
      Grant-in-Aid for Scientific Research (S)
    • Review Section
      Broad Section H
    • Research Institution
      Kyoto University

  •  トランスクリプトームの人為的操作による遺伝病の治療Principal Investigator

    • Principal Investigator
      萩原 正敏
    • Project Period (FY)
      2015
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      General pharmacology
    • Research Institution
      Kyoto University

  •  Therapeutic Drug Discovery and Elucidation of RNA Disease Pathogenesis by Use of CRISPR-Based Disease iPS Cells and Animal ModelsPrincipal Investigator

    • Principal Investigator
      Hagiwara Masatoshi
    • Project Period (FY)
      2015 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (S)
    • Research Field
      Chemical biology
    • Research Institution
      Kyoto University

  •  Strategy for controlling intractable pain by targeting casein kinase 1 signaling system

    • Principal Investigator
      Kurihara Takashi
    • Project Period (FY)
      2013 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pain science
    • Research Institution
      Kagoshima University

  •  Identification of a small molecule that induces autophagy-mediated degradation of TAUPrincipal Investigator

    • Principal Investigator
      HAGIWARA Masatoshi
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Chemical biology
    • Research Institution
      Kyoto University

  •  Analysis of abnormal splicing mechanism and application for thetreatment of Muscular Dystrophy

    • Principal Investigator
      KATAOKA Naoyuki
    • Project Period (FY)
      2010 – 2012
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      ケミカルバイオロジー
    • Research Institution
      Kyoto University
      Tokyo Medical and Dental University

  •  Analyzing neuronal development through deciphering splicing codePrincipal Investigator

    • Principal Investigator
      HAGIWARA Masatoshi
    • Project Period (FY)
      2009 – 2011
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      General pharmacology
    • Research Institution
      Kyoto University
      Tokyo Medical and Dental University

  •  ヘルペスウイルスRNAの核外輸送制御機構の解明Principal Investigator

    • Principal Investigator
      萩原 正敏
    • Project Period (FY)
      2007 – 2008
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Tokyo Medical and Dental University

  •  Molecular Mechanism of Inronless mRNA transportPrincipal Investigator

    • Principal Investigator
      HAGIWARA Masatoshi
    • Project Period (FY)
      2007 – 2008
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      General medical chemistry
    • Research Institution
      Tokyo Medical and Dental University

  •  Decipher the mechanism to generate proteome diversity with area specificity in mammalian central nervous system

    • Principal Investigator
      TAKEUCHI Akihide
    • Project Period (FY)
      2007 – 2008
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Neuroscience in general
    • Research Institution
      Tokyo Medical and Dental University

  •  ケミカルジェネティクスによる生体機能の解明Principal Investigator

    • Principal Investigator
      萩原 正敏
    • Project Period (FY)
      2006
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Living organism molecular science
    • Research Institution
      Tokyo Medical and Dental University

  •  生体における組織特異的選択的スプライシング制御機構の解明

    • Principal Investigator
      黒柳 秀人
    • Project Period (FY)
      2005
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Tokyo Medical and Dental University

  •  新規リン酸化酵素阻害剤によるスプライシング制御とエイズウイルスの複製阻害

    • Principal Investigator
      FUKUHARA Takeshi
    • Project Period (FY)
      2004 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Tokyo Medical and Dental University

  •  Manipulation of aberrant splicing.Principal Investigator

    • Principal Investigator
      HAGIWARA Masatoshi
    • Project Period (FY)
      2004 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      General medical chemistry
    • Research Institution
      Tokyo Medical and Dental University

  •  Biobjeによる遺伝子発現シミュレーションの線虫個体への応用

    • Principal Investigator
      木村 芳滋
    • Project Period (FY)
      2002
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Tokyo Medical and Dental University

  •  Phosphorylation-dependent regulation of splicing and transport of mRNAPrincipal Investigator

    • Principal Investigator
      HAGIWARA Masatoshi
    • Project Period (FY)
      2002 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Tokyo University of Agriculture and Technology
      Tokyo Medical and Dental University

  •  Phosphoiylation -dependent regulation of alternative splicingPrincipal Investigator

    • Principal Investigator
      HAGIWARA Masatoshi
    • Project Period (FY)
      2002 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Molecular biology
    • Research Institution
      Tokyo Medical and Dental University

  •  歌学習臨界期におけるキンカチョウ脳内CREBの活性化と遺伝子発現変動Principal Investigator

    • Principal Investigator
      萩原 正敏
    • Project Period (FY)
      2001
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Review Section
      Biological Sciences
    • Research Institution
      Tokyo Medical and Dental University

  •  Biobjeによる遺伝子発現制御機構のシミュレーションPrincipal Investigator

    • Principal Investigator
      萩原 正敏
    • Project Period (FY)
      2001
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (C)
    • Review Section
      Biological Sciences
    • Research Institution
      Tokyo Medical and Dental University

  •  生物新機能と創薬をめざす生体内分子科学

    • Principal Investigator
      鈴木 正昭
    • Project Period (FY)
      2001 – 2005
    • Research Category
      Grant-in-Aid for Creative Scientific Research
    • Research Institution
      Gifu University

  •  スプライシング因子リン酸化酵素の活性制御機構Principal Investigator

    • Principal Investigator
      萩原 正敏
    • Project Period (FY)
      2000
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Research Institution
      Tokyo Medical and Dental University

  •  キンカチョウの歌学習機構における転写因子CREBの役割Principal Investigator

    • Principal Investigator
      萩原 正敏
    • Project Period (FY)
      2000
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Review Section
      Biological Sciences
    • Research Institution
      Tokyo Medical and Dental University

  •  遺伝子発現過程のOIMによるシミュレーションPrincipal Investigator

    • Principal Investigator
      萩原 正敏
    • Project Period (FY)
      2000
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (C)
    • Review Section
      Biological Sciences
    • Research Institution
      Tokyo Medical and Dental University

  •  選択的スプライシングのリン酸化制御機構Principal Investigator

    • Principal Investigator
      萩原 正敏
    • Project Period (FY)
      1999
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Research Institution
      Tokyo Medical and Dental University

  •  アポトーシスの細胞内リアルタイムイメージングPrincipal Investigator

    • Principal Investigator
      萩原 正敏
    • Project Period (FY)
      1999
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      General medical chemistry
    • Research Institution
      Tokyo Medical and Dental University

  •  細胞内情報伝達の生理機能解析と情報分子の可視化

    • Principal Investigator
      飯野 正光
    • Project Period (FY)
      1998
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Research Institution
      The University of Tokyo

  •  転写因子ATF1による細胞増殖制御とその融合遺伝子による癌化機構の解明Principal Investigator

    • Principal Investigator
      萩原 正敏
    • Project Period (FY)
      1998
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Research Institution
      Tokyo Medical and Dental University

  •  mRNA factoryのリン酸化制御Principal Investigator

    • Principal Investigator
      萩原 正敏
    • Project Period (FY)
      1998
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Research Institution
      Tokyo Medical and Dental University

  •  GFP蛍光による細胞内リン酸化反応のイメージングPrincipal Investigator

    • Principal Investigator
      萩原 正敏
    • Project Period (FY)
      1998
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      General medical chemistry
    • Research Institution
      Tokyo Medical and Dental University

  •  New methods for expression cloning of alternative splicing factorsPrincipal Investigator

    • Principal Investigator
      HAGIWARA Masatoshi
    • Project Period (FY)
      1998 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Functional biochemistry
    • Research Institution
      TOKYO MEDICAL & DENTAL UNIVERSITY

  •  悪性黒色腫に発現する融合症遺伝子EWS/ATF1の癌化機構における役割の解明Principal Investigator

    • Principal Investigator
      萩原 正敏
    • Project Period (FY)
      1997
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Tokyo Medical and Dental University

  •  Prospero相同遺伝子はCREBによって制御され神経可塑性に関与するのか?Principal Investigator

    • Principal Investigator
      萩原 正敏
    • Project Period (FY)
      1997
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Tokyo Medical and Dental University

  •  Molecular mechanisms of functional expression of transcription regulation factors through their interaction with coactivators or corepressors

    • Principal Investigator
      FUJII-KURIYAMA Yoshiaki
    • Project Period (FY)
      1997 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Research Institution
      Tohoku University

  •  New vector system for the gene therapy of abdominal cancers.

    • Principal Investigator
      NIMURA Yuji
    • Project Period (FY)
      1997 – 1998
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Digestive surgery
    • Research Institution
      Nagoya University

  •  CREB結合蛋白CBPのリン酸化による制御Principal Investigator

    • Principal Investigator
      萩原 正敏
    • Project Period (FY)
      1996
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Nagoya University

  •  リン酸化による転写調節因子構造変化のイメージング

    • Principal Investigator
      臼倉 治郎
    • Project Period (FY)
      1996
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Nagoya University

  •  CREB欠損ショウジョウバエを用いる記憶関連遺伝子のサブトラクションクローニングPrincipal Investigator

    • Principal Investigator
      萩原 正敏
    • Project Period (FY)
      1996
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Nagoya University

  •  CREB/ATF1ドミナント・ネガティブ分子の構築と遺伝子改変マウスの作成Principal Investigator

    • Principal Investigator
      萩原 正敏
    • Project Period (FY)
      1996
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      General medical chemistry
    • Research Institution
      Nagoya University

  •  IMAGING OF PHOTOTRANSDUCTION PROCESS IN RENTINAL CELLS

    • Principal Investigator
      USUKURA Jiro
    • Project Period (FY)
      1996
    • Research Category
      Grant-in-Aid for international Scientific Research
    • Research Institution
      Nagoya University

  •  Identification of novel protein kinases from Beghet patientsserPrincipal Investigator

    • Principal Investigator
      HAGIWARA Masatoshi
    • Project Period (FY)
      1996 – 1997
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Pathological medical chemistry
    • Research Institution
      Tokyo Medical and Dental University
      Nagoya University

  •  CREB結合蛋白CBPの多様性とそのリン酸化制御機構 -ATF/CREBファミリーの特異性はCBPによって説明可能か-Principal Investigator

    • Principal Investigator
      萩原 正敏
    • Project Period (FY)
      1995
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Nagoya University

  •  リン酸化による転写調節因子構造変化のイメージング

    • Principal Investigator
      臼倉 治郎
    • Project Period (FY)
      1995
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Nagoya University

  •  接着分子CD44の脳腫瘍における過剰発現機構とその生物学的意義Principal Investigator

    • Principal Investigator
      萩原 正敏
    • Project Period (FY)
      1995
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Nagoya University

  •  長期記憶に関与する転写調節因子CREBのターゲット遺伝子のクローニングPrincipal Investigator

    • Principal Investigator
      萩原 正敏
    • Project Period (FY)
      1995
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Nagoya University

  •  蛋白リン酸化酵素の核内輸送機構と新しい核膜孔複合体の探求Principal Investigator

    • Principal Investigator
      萩原 正敏
    • Project Period (FY)
      1995
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Nagoya University

  •  Analysis of signal transduction in human glioma cells transfected with cytokine gene

    • Principal Investigator
      YOSHIDA Jun
    • Project Period (FY)
      1995 – 1997
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Cerebral neurosurgery
    • Research Institution
      Nagoya University

  •  転写調節因子CREBの細胞内ソーティングとそのリン酸化制御Principal Investigator

    • Principal Investigator
      萩原 正敏
    • Project Period (FY)
      1994
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Nagoya University

  •  リン酸化による転写調節因子構造変化のイメージング

    • Principal Investigator
      USUKURA Jiro
    • Project Period (FY)
      1994
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Nagoya University

  •  受容体から核へcAMPシグナルを伝達するAキナーゼの細胞内ソーティングPrincipal Investigator

    • Principal Investigator
      萩原 正敏
    • Project Period (FY)
      1994
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      General pharmacology
    • Research Institution
      Nagoya University

  •  Cloning of CBP and its regulation mechanismPrincipal Investigator

    • Principal Investigator
      HAGIWARA Masatoshi
    • Project Period (FY)
      1994 – 1996
    • Research Category
      Grant-in-Aid for international Scientific Research
    • Research Institution
      Tokyo Medical and Dental University
      Nagoya University

  •  Molecular basis and generation of new compounds for probing phosphorylation-mediated signaling pathways

    • Principal Investigator
      HIDAKA Hiroyoshi
    • Project Period (FY)
      1994 – 1996
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      General pharmacology
    • Research Institution
      Nagoya University

  •  リン酸化依存性転写調節因子と転写基本因子との間に介存する制御因子の探求Principal Investigator

    • Principal Investigator
      萩原 正敏
    • Project Period (FY)
      1993
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Nagoya University

  •  受容体から核内の転写因子CREBに至るcAMPシグナルトランスダクションの研究Principal Investigator

    • Principal Investigator
      萩原 正敏
    • Project Period (FY)
      1993
    • Research Category
      Grant-in-Aid for Encouragement of Young Scientists (A)
    • Research Field
      Cell biology
    • Research Institution
      Nagoya University

  •  ヒト甲状腺細胞の癌化・増殖過程に関与するβ型Cキナ-ゼの薬理学的解析Principal Investigator

    • Principal Investigator
      萩原 正敏
    • Project Period (FY)
      1991
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      General pharmacology
    • Research Institution
      Nagoya University

  •  The Development of the Strategy for the Presumption of the Tertiary Structure of Protein Kinases by Specific Inhibitors

    • Principal Investigator
      HIDAKA Hiroyoshi
    • Project Period (FY)
      1990 – 1992
    • Research Category
      Grant-in-Aid for Developmental Scientific Research (B)
    • Research Field
      General pharmacology
    • Research Institution
      Nagoya University

  •  Functional Modification of Calcium Dependent Proteins by Phosphorylation

    • Principal Investigator
      KOBAYASHI Ryoji
    • Project Period (FY)
      1990 – 1991
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      代謝生物化学
    • Research Institution
      Nagoya University

  •  Cキナ-ゼサブタイプの定量化、及び細胞の癌化に果たす役割の解析

    • Principal Investigator
      HIDAKA Hiroyoshi
    • Project Period (FY)
      1989
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Nagoya University

  •  Unification and reconstruction of myosin phosphorylation theory on contractile response of smooth muscle and nonmuscle cells.

    • Principal Investigator
      HIDAKA Hiroyoshi
    • Project Period (FY)
      1989 – 1991
    • Research Category
      Grant-in-Aid for international Scientific Research
    • Research Institution
      Nagoya University

  •  The role of Ca^<2+>-dependent protein kinases in central nervous system in health and diseases.

    • Principal Investigator
      HIDAKA Hiroyoshi
    • Project Period (FY)
      1989 – 1991
    • Research Category
      Grant-in-Aid for General Scientific Research (A)
    • Research Field
      Pathological medical chemistry
    • Research Institution
      Nagoya University

  •  Development of analytical method of molecular function in protein kinases by using newly synthesized protein kinase inhibitor - affinity chromatography

    • Principal Investigator
      HIDAKA Hiroyoshi
    • Project Period (FY)
      1987 – 1988
    • Research Category
      Grant-in-Aid for Developmental Scientific Research
    • Research Field
      物質生物化学
    • Research Institution
      Nagoya University School of Medicine
      Mie University

All 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 2002 Other

All Journal Article Presentation Book Patent

  • [Book] 最前線の生命科学者２３人が教える　いのちを科学する仕事2020
    • Author(s)
      萩原正敏
    • Total Pages
      240
    • Publisher
      朝日新聞出版
    • ISBN
      9784023318731
    • Data Source
      KAKENHI-PROJECT-15H05721

  • [Book] 目からウロコの疣贅診療ハンドブック－困った時のこの一冊2020
    • Author(s)
      萩原正敏
    • Total Pages
      224
    • Publisher
      南江堂
    • ISBN
      9784524246830
    • Data Source
      KAKENHI-PROJECT-15H05721

  • [Book] 月刊臨床神経科学　CLINICAL NEUROSCIENCE　Vol.38 No.122020
    • Author(s)
      小林亜希子、萩原正敏
    • Total Pages
      136
    • Publisher
      中外医学社
    • Data Source
      KAKENHI-PROJECT-15H05721

  • [Book] 月刊メディカル・サイエンス・ダイジェスト　8月号 Vol.46 No.9 2020 通巻610号2020
    • Author(s)
      網代将彦、萩原正敏
    • Total Pages
      57
    • Publisher
      ニュー・サイエンス社
    • Data Source
      KAKENHI-PROJECT-15H05721

  • [Book] 動き出す医療産業DX RNAを標的としたアカデミア創薬2020
    • Author(s)
      萩原正敏
    • Total Pages
      162
    • Publisher
      日経ＢＰ
    • ISBN
      9784296105762
    • Data Source
      KAKENHI-PROJECT-15H05721

  • [Book] Precision Medicine 2019年6月号 「特集：ゲノム創薬によるプレシジョンメディシンの実現」2019
    • Author(s)
      萩原正敏
    • Total Pages
      100
    • Publisher
      ニュー・サイエンス社
    • Data Source
      KAKENHI-PROJECT-15H05721

  • [Book] ケミカルバイオロジーから創薬へ2016
    • Author(s)
      萩原正敏
    • Total Pages
      3
    • Publisher
      東京化学同人
    • Data Source
      KAKENHI-PROJECT-15H05721

  • [Book] 選択的スプライシング・ネットワークを化合物で操作する。2015
    • Author(s)
      大江賢治、萩原正敏
    • Total Pages
      5
    • Publisher
      医学書院
    • Data Source
      KAKENHI-PROJECT-15H05721

  • [Book] リン酸化酵素に対する選択的阻害剤の開発　「生物活性分子のケミカルバイオロジー　標的同定と作用機構」2015
    • Author(s)
      喜井勲、萩原正敏
    • Total Pages
      6
    • Publisher
      化学同人
    • Data Source
      KAKENHI-PROJECT-24241076

  • [Book] 選択的スプライシング・ネットワークを化合物で操作する。Controlling the alternative splicing network with compounds　「生体の科学」第66巻2号2015
    • Author(s)
      大江賢治、萩原正敏
    • Total Pages
      5
    • Publisher
      医学書院
    • Data Source
      KAKENHI-PROJECT-24241076

  • [Book] RNA病　(2014)　分子精神医学Vol.14　No.22014
    • Author(s)
      木村亮、萩原正敏
    • Total Pages
      2
    • Publisher
      株式会社先端医学社
    • Data Source
      KAKENHI-PROJECT-24241076

  • [Book] 実験医学・増刊「疾患克服をめざしたケミカルバイオロジー」RNAを標的とした新しい創薬戦略2012
    • Author(s)
      片岡直行、萩原正敏
    • Data Source
      KAKENHI-PROJECT-22603002

  • [Book] 細胞・特集「RNAバイオロジーの最先端」mRNAを標的とした新しい疾患治療戦略2012
    • Author(s)
      片岡直行、萩原正敏
    • Data Source
      KAKENHI-PROJECT-22603002

  • [Book] 細胞工学・特集「RNAプロセシング異常」RNAスプライシング操作によるRNA病治療戦略2010
    • Author(s)
      片岡直行、萩原正敏
    • Data Source
      KAKENHI-PROJECT-22603002

  • [Journal Article] Identification of Qk as a Glial Precursor Cell Marker that Governs the Fate Specification of Neural Stem Cells to a Glial Cell Lineage2020
    • Author(s)
      Takeuchi Akihide、Takahashi Yuji、Iida Kei、Hosokawa Motoyasu、Irie Koichiro、Ito Mikako、Brown J.B.、Ohno Kinji、Nakashima Kinichi、Hagiwara Masatoshi
    • Journal Title

      Stem Cell Reports

      Volume: 15 Issue: 4 Pages: 883-897

    • DOI

      10.1016/j.stemcr.2020.08.010

    • NAID

      120006888017

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K06907, KAKENHI-PROJECT-20K06925, KAKENHI-PROJECT-19K22802, KAKENHI-PROJECT-15H05721, KAKENHI-PROJECT-20H03561, KAKENHI-PROJECT-17K07094

  • [Journal Article] Integrated DNA methylation analysis reveals a potential role for ANKRD30B in Williams syndrome2020
    • Author(s)
      Ryo Kimura, Roy Lardenoije, Kiyotaka Tomiwa, Yasuko Funabiki, Masatoshi Nakata, Shiho Suzuki, Tomonari Awaya, Takeo Kato, Shin Okazaki, Toshiya Murai, Toshio Heike, Bart P F Rutten, Masatoshi Hagiwara
    • Journal Title

      Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology

      Volume: 45 Issue: 10 Pages: 1627-1636

    • DOI

      10.1038/s41386-020-0675-2

    • NAID

      120006840165

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K08251, KAKENHI-PROJECT-15H05721

  • [Journal Article] Multilateral Bioinformatics Analyses Reveal the Function-Oriented Target Specificities and Recognition of the RNA-Binding Protein SFPQ2020
    • Author(s)
      Iida Kei、Hagiwara Masatoshi、Takeuchi Akihide
    • Journal Title

      iScience

      Volume: 23 Issue: 7 Pages: 101325-101325

    • DOI

      10.1016/j.isci.2020.101325

    • NAID

      120006875263

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K06907, KAKENHI-PROJECT-15H05721

  • [Journal Article] Dysregulation of the oxytocin receptor gene in Williams syndrome2020
    • Author(s)
      Kimura Ryo、Tomiwa Kiyotaka、Inoue Ryo、Suzuki Shiho、Nakata Masatoshi、Awaya Tomonari、Kato Takeo、Okazaki Shin、Heike Toshio、Hagiwara Masatoshi
    • Journal Title

      Psychoneuroendocrinology

      Volume: 115 Pages: 104631-104631

    • DOI

      10.1016/j.psyneuen.2020.104631

    • NAID

      120006813279

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K08251, KAKENHI-PROJECT-15H05721

  • [Journal Article] Directed induction of alveolar type I cells derived from pluripotent stem cells via Wnt signaling inhibition2020
    • Author(s)
      Kanagaki Shuhei、Ikeo Satoshi、Suezawa Takahiro、Yamamoto Yuki、Seki Masahide、Hirai Toyohiro、Hagiwara Masatoshi、Suzuki Yutaka、Gotoh Shimpei
    • Journal Title

      STEM CELLS

      Volume: 39 Issue: 2 Pages: 156-169

    • DOI

      10.1002/stem.3302

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15H05721, KAKENHI-PROJECT-20H03687, KAKENHI-PROJECT-17H05084, KAKENHI-PROJECT-16H06279

  • [Journal Article] Mechanism-Based Personalized Medicine for Cystic Fibrosis by Suppressing Pseudo Exon Inclusion2020
    • Author(s)
      Saiko Shibata, Masahiko Ajiro (#), and Masatoshi Hagiwara (#)
    • Journal Title

      Cell Chemical Biology

      Volume: 27(12) Issue: 12 Pages: 1472-1482

    • DOI

      10.1016/j.chembiol.2020.08.013

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19K07367, KAKENHI-PROJECT-15H05721

  • [Journal Article] Loss of RNA-binding protein Sfpq causes long-gene transcriptopathy in skeletal muscle and severe muscle mass reduction with metabolic myopathy.2019
    • Author(s)
      Hosokawa M, Takeuchi A, Tanihata J, Iida K, Takeda S, Hagiwara M
    • Journal Title

      iScience

      Volume: 13 Pages: 229-242

    • DOI

      10.1016/j.isci.2019.02.023

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16K08726, KAKENHI-PROJECT-15H05721

  • [Journal Article] An epigenetic biomarker for adult high-functioning autism spectrum disorder2019
    • Author(s)
      Kimura Ryo、Nakata Masatoshi、Funabiki Yasuko、Suzuki Shiho、Awaya Tomonari、Murai Toshiya、Hagiwara Masatoshi
    • Journal Title

      Scientific Reports

      Volume: 9 Issue: 1 Pages: 13662-13662

    • DOI

      10.1038/s41598-019-50250-9

    • NAID

      120006726165

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K08251, KAKENHI-PROJECT-15H05721

  • [Journal Article] In Vitro Disease Modeling of Hermansky-Pudlak Syndrome Type 2?Using Human Induced Pluripotent Stem Cell-Derived Alveolar Organoids2019
    • Author(s)
      Korogi Yohei、Gotoh Shimpei、Ikeo Satoshi、Yamamoto Yuki、Sone Naoyuki、Tamai Koji、Konishi Satoshi、Nagasaki Tadao、Matsumoto Hisako、Ito Isao、Chen-Yoshikawa Toyofumi F.、Date Hiroshi、Hagiwara Masatoshi、Asaka Isao、Hotta Akitsu、Mishima Michiaki、Hirai Toyohiro
    • Journal Title

      Stem Cell Reports

      Volume: 13 Issue: 1 Pages: 235-235

    • DOI

      10.1016/j.stemcr.2019.05.022

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H05721

  • [Journal Article] In?Vitro Disease Modeling of Hermansky-Pudlak Syndrome Type 2?Using Human Induced Pluripotent Stem Cell-Derived Alveolar Organoids2019
    • Author(s)
      Korogi Yohei、Gotoh Shimpei、Ikeo Satoshi、Yamamoto Yuki、Sone Naoyuki、Tamai Koji、Konishi Satoshi、Nagasaki Tadao、Matsumoto Hisako、Ito Isao、Chen-Yoshikawa Toyofumi F.、Date Hiroshi、Hagiwara Masatoshi、Asaka Isao、Hotta Akitsu、Mishima Michiaki、Hirai Toyohiro
    • Journal Title

      Stem Cell Reports

      Volume: 12 Issue: 3 Pages: 431-440

    • DOI

      10.1016/j.stemcr.2019.01.014

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17H05084, KAKENHI-PROJECT-17H04183, KAKENHI-PROJECT-15H05721

  • [Journal Article] MicroRNA profiling in adults with high-functioning autism spectrum disorder2019
    • Author(s)
      Nakata Masatoshi、Kimura Ryo、Funabiki Yasuko、Awaya Tomonari、Murai Toshiya、Hagiwara Masatoshi
    • Journal Title

      Molecular Brain

      Volume: 12 Issue: 1 Pages: 82-82

    • DOI

      10.1186/s13041-019-0508-6

    • NAID

      120006764460

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K08251, KAKENHI-PROJECT-15H05721

  • [Journal Article] Verification and rectification of cell type-specific splicing of a Seckel syndrome-associated ATR mutation using iPS cell model2019
    • Author(s)
      Ichisima Jose、Suzuki Naoya M.、Samata Bumpei、Awaya Tomonari、Takahashi Jun、Hagiwara Masatoshi、Nakahata Tatsutoshi、Saito Megumu K.
    • Journal Title

      Journal of Human Genetics

      Volume: 64 Issue: 5 Pages: 445-458

    • DOI

      10.1038/s10038-019-0574-8

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H05721, KAKENHI-PROJECT-17J08574, KAKENHI-PROJECT-16H05352

  • [Journal Article] Loss of Sfpq Causes Long-Gene Transcriptopathy in the Brain2018
    • Author(s)
      Takeuchi Akihide、Iida Kei、Tsubota Toshiaki、Hosokawa Motoyasu、Denawa Masatsugu、Brown J.B.、Ninomiya Kensuke、Ito Mikako、Kimura Hiroshi、Abe Takaya、Kiyonari Hiroshi、Ohno Kinji、Hagiwara Masatoshi
    • Journal Title

      Cell Reports

      Volume: 23 Issue: 5 Pages: 1326-1341

    • DOI

      10.1016/j.celrep.2018.03.141

    • NAID

      120006463742

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K07094, KAKENHI-PROJECT-15H05721

  • [Journal Article] Convergent synthesis of trifunctional molecules by three sequential azido-type-selective cycloadditions2018
    • Author(s)
      Yoshida Suguru、Kanno Kimiyuki、Kii Isao、Misawa Yoshihiro、Hagiwara Masatoshi、Hosoya Takamitsu
    • Journal Title

      Chemical Communications

      Volume: 54 Issue: 30 Pages: 3705-3708

    • DOI

      10.1039/c8cc01195h

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PUBLICLY-16H01133, KAKENHI-PROJECT-15H03118, KAKENHI-PLANNED-17H06414, KAKENHI-PROJECT-15H05721

  • [Journal Article] CDK9 Inhibitor FIT-039 Suppresses Viral Oncogenes E6 and E7 and Has a Therapeutic Effect on HPV-Induced Neoplasia2018
    • Author(s)
      Ajiro Masahiko、Sakai Hiroyuki、Onogi Hiroshi、Yamamoto Makoto、Sumi Eriko、Sawada Teruo、Nomura Takashi、Kabashima Kenji、Hosoya Takamitsu、Hagiwara Masatoshi
    • Journal Title

      Clinical Cancer Research

      Volume: 24 Issue: 18 Pages: 4518-4528

    • DOI

      10.1158/1078-0432.ccr-17-3119

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-17H06414, KAKENHI-PROJECT-15H05721

  • [Journal Article] Loss of Sfpq causes long-gene transcriptopathy in the brain.2018
    • Author(s)
      Takeuchi A, Iida K, Tsubota T, Hosokawa M, Denawa M, Brown JB, Ninomiya K, Ito M, Kimura H, Abe T, Kiyonari H, Ohno K, and Hagiwara M
    • Journal Title

      Cell Reports.

      Volume: 23 Issue: 5 Pages: 1326-1341

    • NAID

      120006463742

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21249013

  • [Journal Article] Rescue of recurrent deep intronic mutation underlying cell type-dependent quantitative NEMO deficiency2018
    • Author(s)
      Boisson Bertrand、Honda Yoshitaka、Ajiro Masahiko、Bustamante Jacinta、Bendavid Matthieu、Gennery Andrew R.、Kawasaki Yuri、Ichishima Jose、Osawa Mitsujiro、Nihira Hiroshi、Shiba Takeshi、Tanaka Takayuki、Chrabieh Maya、Bigio Benedetta、Hur Hong、Itan Yuval、Liang Yupu、Okada Satoshi、et al.
    • Journal Title

      Journal of Clinical Investigation

      Volume: 129 Issue: 2 Pages: 583-597

    • DOI

      10.1172/jci124011

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18KK0228, KAKENHI-PROJECT-15H05721, KAKENHI-PROJECT-16H05352, KAKENHI-PROJECT-16H05355, KAKENHI-PROJECT-17J08574, KAKENHI-PROJECT-19K07367

  • [Journal Article] Development of an orally available inhibitor of CLK1 for skipping a mutated dystrophin exon in Duchenne muscular dystrophy2017
    • Author(s)
      Sako Yukiya、Ninomiya Kensuke、Okuno Yukiko、Toyomoto Masayasu、Nishida Atsushi、Koike Yuka、Ohe Kenji、Kii Isao、Yoshida Suguru、Hashimoto Naohiro、Hosoya Takamitsu、Matsuo Masafumi、Hagiwara Masatoshi
    • Journal Title

      Scientific Reports

      Volume: 7 Issue: 1 Pages: 46126-46126

    • DOI

      10.1038/srep46126

    • NAID

      120006355767

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15H05721, KAKENHI-PROJECT-15K10050, KAKENHI-PROJECT-21249013

  • [Journal Article] In vitro expansion of mouse primordial germ cell-like cells recapitulates an epigenetic blank slate.2017
    • Author(s)
      Ohta H, Kurimoto K, Okamoto I, Nakamura T, Yabuta Y, Miyauchi H, Yamamoto T, Okuno Y, Hagiwara M, Shirane K, Sasaki H, Saitou M
    • Journal Title

      EMBO J

      Volume: 36 Issue: 13 Pages: 1888-1907

    • DOI

      10.15252/embj.201695862

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PUBLICLY-16H01216, KAKENHI-ORGANIZER-25112001, KAKENHI-PLANNED-25112010, KAKENHI-PROJECT-16H04720, KAKENHI-PROJECT-15H05636, KAKENHI-PROJECT-21249013, KAKENHI-PROJECT-17H06098

  • [Journal Article] RBM24 promotes U1 snRNP recognition of the mutated 5′ splice site in the IKBKAP gene of familial dysautonomia2017
    • Author(s)
      Ohe Kenji、Yoshida Mayumi、Nakano-Kobayashi Akiko、Hosokawa Motoyasu、Sako Yukiya、Sakuma Maki、Okuno Yukiko、Usui Tomomi、Ninomiya Kensuke、Nojima Takayuki、Kataoka Naoyuki、Hagiwara Masatoshi
    • Journal Title

      RNA

      Volume: 23 Issue: 9 Pages: 1393-1403

    • DOI

      10.1261/rna.059428.116

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15H05721, KAKENHI-PROJECT-15K10050, KAKENHI-PROJECT-21249013

  • [Journal Article] Retinoid derivative Tp80 exhibits anti-hepatitis C virus activity through restoration of GI-GPx expression.2017
    • Author(s)
      Ngoc NB, Okuno Y, Ajiro M, Iida K, Denawa M, Yamamoto M, Sakamoto N, Kagechika H, Hagiwara M
    • Journal Title

      J Med Virol

      Volume: Epub ahead of print Issue: 7 Pages: 1224-1234

    • DOI

      10.1002/jmv.24739

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16H05282, KAKENHI-PROJECT-15H05721, KAKENHI-PROJECT-16K15420

  • [Journal Article] Prenatal neurogenesis induction therapy normalizes brain structure and function in Down syndrome mice2017
    • Author(s)
      Akiko Nakano-Kobayashi, Tomonari Awaya, Isao Kii, Yuto Sumida, Yukiko Okuno, Suguru Yoshida, Tomoe Sumida, Haruhisa Inoue, Takamitsu Hosoya and Masatoshi Hagiwara
    • Journal Title

      Proceedings of the National Academy of Sciences of the United States of america

      Volume: 114 Issue: 38 Pages: 10268-10273

    • DOI

      10.1073/pnas.1704143114

    • NAID

      130007900113

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16K01932, KAKENHI-PROJECT-15H05721, KAKENHI-PROJECT-16H05926, KAKENHI-PROJECT-21249013, KAKENHI-PROJECT-16K17907

  • [Journal Article] Selective inhibition of the kinase DYRK1A by targeting its folding process.2016
    • Author(s)
      Kii I, Sumida Y, Goto T, Sonamoto R, Okuno Y, Yoshida S, Kato-Sumida T, Koike Y, Abe M, Nonaka Y, Ikura T, Ito N, Shibuya H, Hosoya T, & Hagiwara M
    • Journal Title

      Nature Communications

      Volume: 7 Pages: 1038-1090

    • NAID

      120005770755

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15H05721

  • [Journal Article] Selective inhibition of the kinase DYRK1A by targeting its folding process2016
    • Author(s)
      Kii I., Sumida Y., Goto T., Sonamoto R., Okuno Y., Yoshida S., Kato-Sumida T., Koike Y., Abe M., Nonaka Y., Ikura T., Ito N., Shibuya H., Hosoya T., Hagiwara M.
    • Journal Title

      Nat. Commun.

      Volume: 該当なし Issue: 1 Pages: 11391-11391

    • DOI

      10.1038/ncomms11391

    • NAID

      120005770755

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15K08262, KAKENHI-PROJECT-16H05926, KAKENHI-PROJECT-15H05721, KAKENHI-PROJECT-21249013

  • [Journal Article] ケミカルバイオロジーから創薬へ2016
    • Author(s)
      萩原正敏
    • Journal Title

      現代化学

      Volume: 541 Pages: 28-30

    • Data Source
      KAKENHI-PROJECT-21249013

  • [Journal Article] 家族性自律神経失調症の治療薬候補2016
    • Author(s)
      大江賢治、萩原正敏
    • Journal Title

      医学のあゆみ

      Volume: 257 Issue: 4 Pages: 318-319

    • Data Source
      KAKENHI-PROJECT-21249013

  • [Journal Article] 次世代抗ウイルス薬の開発2015
    • Author(s)
      山本誠、萩原正敏
    • Journal Title

      感染・炎症・免疫

      Volume: 45 Issue: 1

    • Data Source
      KAKENHI-PROJECT-21249013

  • [Journal Article] Identification of a DYRK1A Inhibitor that Induces Degradation of the Target Kinase using Co-chaperone CDC37 fused with Luciferase nanoKAZ2015
    • Author(s)
      Sonamoto　R, Kii I, Koike Y, Sumida Y, Kato-Sumida T, Okuno Y, Hosoya T, and Hagiwara M
    • Journal Title

      Scientific Reports

      Volume: 5 Issue: 1 Pages: 1-86

    • DOI

      10.1038/srep12728

    • NAID

      120005820881

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15H05721, KAKENHI-PROJECT-21249013

  • [Journal Article] Deciphering targeting rules of splicing modulator compounds: case of TG003.2015
    • Author(s)
      Sakuma M, Iida K, Hagiwara M
    • Journal Title

      BMC Mol Biol.

      Volume: 16 Issue: 1 Pages: 16-16

    • DOI

      10.1186/s12867-015-0044-6

    • NAID

      120005758276

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-15K18459, KAKENHI-PROJECT-15H05721, KAKENHI-PROJECT-21249013

  • [Journal Article] 選択的スプライシング・ネットワークを化合物で操作する。Controlling the alternative splicing network with compounds2015
    • Author(s)
      大江賢治、萩原正敏
    • Journal Title

      生体の科学

      Volume: 66 Issue: 2 Pages: 114-118

    • Data Source
      KAKENHI-PROJECT-21249013

  • [Journal Article] Rectifier of aberrant mRNA splicing recovers tRNA modification in familial dysautonomia.2015
    • Author(s)
      Yoshida M, Kataoka N, Miyauchi K, Ohe K, Iida K, Yoshida S, Nojima T, Okuno Y, Onogi H, Usui T, Takeuchi A, Hosoya T, Suzuki T, Hagiwara M.
    • Journal Title

      Proc Natl Acad Sci U S A.

      Volume: 112（9） Issue: 9 Pages: 2764-2769

    • DOI

      10.1073/pnas.1415525112

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-24241076, KAKENHI-PROJECT-25620125, KAKENHI-PROJECT-26220205, KAKENHI-PROJECT-15K10050, KAKENHI-PLANNED-26113003, KAKENHI-PROJECT-15H05721, KAKENHI-PROJECT-21249013

  • [Journal Article] Identification of a Dual Inhibitor of SRPK1 and CK2 that Attenuates Pathological Angiogenesis of Macular Degeneration in Mice.2015
    • Author(s)
      Satoshi Morooka, Mitsuteru Hoshina, Isao Kii, et al.
    • Journal Title

      Molecular Pharmacology

      Volume: 88 Issue: 2 Pages: 316-325

    • DOI

      10.1124/mol.114.097345

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15K20257, KAKENHI-PROJECT-15H05721, KAKENHI-PROJECT-15H02505, KAKENHI-PROJECT-24390392, KAKENHI-PROJECT-21249013

  • [Journal Article] Design and synthesis of a potent inhibitor of class 1 DYRK kinases as a suppressor of adipogenesis.2015
    • Author(s)
      Masaki S, Kii I, Sumida Y, Kato-Sumida, Ogawa Y, Ito N, Nakamura M, Sonamoto R, Kataoka N , Hosoya T, and Hagiwara M
    • Journal Title

      Bioorganic & Medicinal Chemistry

      Volume: 23 Issue: 15 Pages: 4434-4441

    • DOI

      10.1016/j.bmc.2015.06.018

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15H05721, KAKENHI-PROJECT-15H02505, KAKENHI-PROJECT-21249013

  • [Journal Article] Alleviation of behavioral hypersensitivity in mouse models of inflammatory pain with two structurally different casein kinase 1 (CK1) inhibitors.2014
    • Author(s)
      Kurihara T, Sakurai E, Toyomoto M, Kii I, Kawamoto D, Asada T, Tanabe T, Yoshimura M, Hagiwara M, Miyata A.
    • Journal Title

      Mol Pain.

      Volume: 10 Pages: 17-17

    • DOI

      10.1186/1744-8069-10-17

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-24241076, KAKENHI-PROJECT-25460723, KAKENHI-PROJECT-25462225, KAKENHI-PROJECT-26462384

  • [Journal Article] RNA病2014
    • Author(s)
      木村亮、萩原正敏
    • Journal Title

      分子精神医学

      Volume: 114 Issue: 2 Pages: 62-63

    • Data Source
      KAKENHI-PROJECT-21249013

  • [Journal Article] キナーゼの多彩な立体構造を標的とした創薬2014
    • Author(s)
      喜井勲、萩原正敏
    • Journal Title

      実験医学

      Volume: 32 Issue: 2 Pages: 133-139

    • Data Source
      KAKENHI-PROJECT-21249013

  • [Journal Article] RBFOX and SUP-12 sandwich a guanine base to form a stable complex and regulate tissue-specific splicing.2014
    • Author(s)
      Kuwasako K, Takahashi M, Unzai S, Tsuda K, Yoshikawa S, He F, Kobayashi N, Guntert P, Shirouzu M, Ito T, Tanaka A, Yokoyama S, Hagiwara M, Kuroyanagi H, and Muto Y.
    • Journal Title

      Nat. Struct. Mol. Biol.

      Volume: 21(9) Issue: 9 Pages: 778-86

    • DOI

      10.1038/nsmb.2870

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-24241076, KAKENHI-PUBLICLY-25118506, KAKENHI-PROJECT-25440032, KAKENHI-PROJECT-26291003, KAKENHI-PROJECT-21249013

  • [Journal Article] 選択的スプライシングを標的とした低分子化合物の医薬品開発2014
    • Author(s)
      大江賢治、萩原正敏
    • Journal Title

      BIO Clinica BIOLOGYTOPICS

      Volume: 3 Pages: 95-99

    • Data Source
      KAKENHI-PROJECT-21249013

  • [Journal Article] キナーゼの多彩な立体構造を標的とした創薬2014
    • Author(s)
      喜井　勲、萩原　正敏
    • Journal Title

      実験医学増刊

      Volume: 32(2) Pages: 133-139

    • Data Source
      KAKENHI-PROJECT-24241076

  • [Journal Article] CELF family RNA-binding protein UNC-75 regulates two sets of mutually exclusive exons of the unc-32 gene in neuron-specific manners in Caenorhabditis elegans2013
    • Author(s)
      Kuroyanagi H, Watanabe Y, Hagiwara M
    • Journal Title

      PLoS Genetics

      Volume: 9 Issue: 2 Pages: e1003337-e1003337

    • DOI

      10.1371/journal.pgen.1003337

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-20112004, KAKENHI-PROJECT-21249013, KAKENHI-PROJECT-22500288, KAKENHI-PROJECT-24657116

  • [Journal Article] Topical antiangiogenic SRPK1 inhibitors reduce choroidal neovascularization in rodent models of exudative AMD.2013
    • Author(s)
      Gammons MV, Fedorov O, Ivison D, Du C, Clark T, Hopkins C, Hagiwara M, Dick AD, Cox R, Harper SJ, Hancox JC, Knapp S, Bates DO.
    • Journal Title

      Invest Ophthalmol Vis Sci.

      Volume: 54(9) Issue: 9 Pages: 6052-6062

    • DOI

      10.1167/iovs.13-12422

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-24241076, KAKENHI-PROJECT-21249013

  • [Journal Article] Inhibition of DYRK1A destabilizes EGFR and reduces EGFR-dependent glioblastoma growth2013
    • Author(s)
      Pozo N, Zahonero C, Fernández P, Liñares JM, Ayuso A, Hagiwara M, Pérez A, Ricoy JR, Hernández-Laín A, Sepúlveda JM, Sánchez-Gómez P.
    • Journal Title

      J Clin Invest.

      Volume: 123(6) Issue: 6 Pages: 2475-2487

    • DOI

      10.1172/jci63623

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-24241076, KAKENHI-PROJECT-21249013

  • [Journal Article] Specific inhibition of serine/arginine-rich protein kinase attenuates choroidal neovascularization.2013
    • Author(s)
      Dong Z, Noda K, Kanda A, Fukuhara J, Ando R, Murata M, Saito W, Hagiwara M, Ishida S.
    • Journal Title

      Mol Vis.

      Volume: 19 Pages: 536-543

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24241076

  • [Journal Article] hDbr1 is a nucleocytoplasmic shuttling protein with a protein phosphatase-like motif essential for debranching activity2013
    • Author(s)
      Kataoka, N. Hagiwara, M. and Ohno, M
    • Journal Title

      Sci. Rep

      Volume: 3-1090 Issue: 1 Pages: 1090-1090

    • DOI

      10.1038/srep01090

    • NAID

      120005241441

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PLANNED-20112007, KAKENHI-PROJECT-22603002, KAKENHI-ORGANIZER-20112001, KAKENHI-PUBLICLY-23112706, KAKENHI-PROJECT-21249013

  • [Journal Article] CELF family RNA-binding protein UNC-75 regulates two sets of mutually exclusive exons of the unc-32 gene in neuron-specific manners in Caenorhabditis elegans.2013
    • Author(s)
      Kuroyanagi H, Watanabe Y, and Hagiwara M.
    • Journal Title

      PLoS Genet

      Volume: 9(2)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21249013

  • [Journal Article] Specific inhibition of serine/arginine-rich protein kinase attenuates choroidal neovascularization.2013
    • Author(s)
      Dong Z, Noda K, Kanda A, Fukuhara J, Ando R, Murata M, Saito W, Hagiwara M, Ishida S
    • Journal Title

      Mol Vis.

      Volume: 19 Pages: 536-543

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21249013

  • [Journal Article] Position-dependent and neuron-specific splicing regulation by the CELF family RNA-binding protein UNC-75 in Caenorhabditis elegans2013
    • Author(s)
      Kuroyanagi H, Watanabe Y, Suzuki Y, Hagiwara M
    • Journal Title

      Nucleic Acids Research

      Volume: 41 Issue: 7 Pages: 4015-4025

    • DOI

      10.1093/nar/gkt097

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-20112004, KAKENHI-PROJECT-21249013, KAKENHI-PROJECT-24241076, KAKENHI-PROJECT-24657116

  • [Journal Article] RNAを標的とした新しい創薬戦略2012
    • Author(s)
      萩原正敏、片岡直行
    • Journal Title

      実験医学

      Pages: 46-52

    • Data Source
      KAKENHI-PROJECT-21249013

  • [Journal Article] Challenges to congenital genetic disorders with "RNA-targeting" chemical compounds.2012
    • Author(s)
      Ogawa Y, Hagiwara M.
    • Journal Title

      Pharmacol Ther.

      Volume: 134(3) Issue: 3 Pages: 298-305

    • DOI

      10.1016/j.pharmthera.2012.02.001

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21249013, KAKENHI-PROJECT-23659548

  • [Journal Article] 可視化スプライシング・レポーターシステムで開く哺乳類の mRNA 制御の世界2012
    • Author(s)
      武内章英、萩原正敏
    • Journal Title

      細胞工学

      Volume: VOl.31 No.6

    • NAID

      40019333323

    • Data Source
      KAKENHI-PROJECT-21249013

  • [Journal Article] 疾患克服をめざしたケミカルバイオロジー「RNAを標的とした新しい創薬戦略」2012
    • Author(s)
      萩原正敏
    • Journal Title

      実験医学

      Volume: 増刊

    • Data Source
      KAKENHI-PROJECT-24241076

  • [Journal Article] 新しい構造生命科学の未来を拓くために何をなすべきか2012
    • Author(s)
      萩原正敏
    • Journal Title

      学術の動向

      Volume: １２月号

    • Data Source
      KAKENHI-PROJECT-24241076

  • [Journal Article] 可視化スプライシング・レポーターシステムで開く哺乳類のmRNA制御の世界2012
    • Author(s)
      武内章英、萩原正敏
    • Journal Title

      細胞工学

      Volume: 31

    • NAID

      40019333323

    • Data Source
      KAKENHI-PROJECT-21249013

  • [Journal Article] The distribution of phosphorylated SR proteins and alternative splicing are regulated by RANBP22012
    • Author(s)
      Saitoh, N
    • Journal Title

      Mol.Biol.Cell

      Volume: 23 Issue: 6 Pages: 1115-1128

    • DOI

      10.1091/mbc.e11-09-0783

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PUBLICLY-23114719, KAKENHI-PROJECT-21249013

  • [Journal Article] Muscle-Specific Splicing Factors ASD-2 and SUP-12 Cooperatively Switch Alternative Pre-mRNA Processing Patterns of the ADF/Cofilin Gene in Caenorhabditis elegans2012
    • Author(s)
      Ohno G, Ono K, Togo M, Watanabe Y, Ono S, Hagiwara M, Kuroyanagi H
    • Journal Title

      PLoS Genetics

      Volume: 8 Issue: 10 Pages: e1002991-e1002991

    • DOI

      10.1371/journal.pgen.1002991

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-20112004, KAKENHI-PROJECT-21249013, KAKENHI-PROJECT-22500288, KAKENHI-PROJECT-24657116, KAKENHI-ORGANIZER-20112001

  • [Journal Article] Muscle - specific splicing factors ASD - 2 and SUP - 12 cooperatively switch alternative pre - mRNA processing patterns of the ADF/cofilin gene in C. elegans .2012
    • Author(s)
      Ohno G , Ono K , Togo M , Watanabe Y , Ono S ,Hagiwara M , Kuroyanagi H
    • Journal Title

      PLoS Genet

      Volume: 8(10)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21249013

  • [Journal Article] RNA を標的とした新しい創薬戦略2012
    • Author(s)
      萩原正敏、片岡直行
    • Journal Title

      実験医学2012 増刊疾患克服をめざしたケミカルバイオロジー

      Pages: 46-52

    • Data Source
      KAKENHI-PROJECT-21249013

  • [Journal Article] Identification of novel N-(morpholine-4-carbonyloxy) amidine compounds as potent inhibitors against hepatitis C virus replication2012
    • Author(s)
      Kusano-Kitazume A, Sakamoto N, Okuno Y, Sekine-Osajima Y, Nakagawa M, Kakinuma S, Kiyonashi K, Nitta S, Murakawa M, Azuma S, Nishimura-Sakurai Y, Hagiwara M, Watanabe M
    • Journal Title

      Antimicrob Agent Chemother

      Volume: 56(3) Issue: 3 Pages: 1315-23

    • DOI

      10.1128/aac.05764-11

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21590831, KAKENHI-PROJECT-21590832, KAKENHI-PROJECT-23790778, KAKENHI-PROJECT-24390185, KAKENHI-PROJECT-24590957, KAKENHI-PROJECT-24590959, KAKENHI-PROJECT-24659359, KAKENHI-PROJECT-21249013

  • [Journal Article] 新しい構造生命科学の未来を拓くために何をなすべきか2012
    • Author(s)
      萩原正敏
    • Journal Title

      学術の動向

      Volume: 12 Pages: 46-61

    • Data Source
      KAKENHI-PROJECT-21249013

  • [Journal Article] cAMPシグナル2012
    • Author(s)
      萩原正敏
    • Journal Title

      シグナル伝達キーワード事典

      Pages: 53-54

    • Data Source
      KAKENHI-PROJECT-21249013

  • [Journal Article] Chemical treatment enhances skipping of a mutated exon in the dystrophin gene.2011
    • Author(s)
      Nishida A, Kataoka N, Takeshima Y, Yagi M, Awano, H, Ota, M, Itoh K, Hagiwara M, and Matsuo M
    • Journal Title

      Nature Commun

      Volume: 2 Pages: 308-308

    • NAID

      120003001398

    • Data Source
      KAKENHI-PROJECT-21249013

  • [Journal Article] Chemical treatment enhances skipping of a mutated exon in the dystrophin gene2011
    • Author(s)
      Nishida A, Kataoka N, Takeshima Y,Yagi M, Awano, H, Ota, M, Itoh K, Hagiwara M, and Matsuo M
    • Journal Title

      Nat Commun

      Volume: 2 Issue: 1 Pages: 308-308

    • DOI

      10.1038/ncomms1306

    • NAID

      120003001398

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22500288, KAKENHI-PROJECT-22603002, KAKENHI-PUBLICLY-23112706, KAKENHI-PROJECT-23591496

  • [Journal Article] Stress-responsive maturation of Clk1/4 pre-mRNAs promotes phosphorylation of SR splicing factor.2011
    • Author(s)
      Ninomiya K, Kataoka N, andHagiwara M.
    • Journal Title

      J Cell Biol.

      Volume: 195(1) Pages: 27-40

    • Data Source
      KAKENHI-PROJECT-21249013

  • [Journal Article] Chemical treatment enhances skipping of a mutated exon in the dystrophin gene2011
    • Author(s)
      Nishida A, Kataoka N, Takeshima Y, Yagi M, Awano, H, Ota, M, Itoh K, Hagiwara M, Matsuo M
    • Journal Title

      Nature communications

      Volume: 2:308

    • NAID

      120003001398

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21249013

  • [Journal Article] Specific Y14 domains mediate its nucleo- cytoplasmic shuttling and association with spliced mRNA2011
    • Author(s)
      Kataoka, N., Diem, M. D., Yoshida, M., Hatai, C., Dobashi, I., Dreyfuss, G., Hagiwara, M. and Ohno, M
    • Journal Title

      Sci. Rep

      Volume: 1 Issue: 1 Pages: 92-92

    • DOI

      10.1038/srep00092

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-20112007, KAKENHI-PROJECT-22603002, KAKENHI-PUBLICLY-23112706

  • [Journal Article] Stress-responsive maturation of Clk1/4 pre-mRNAs promotes phosphorylation of SR splicing factor2011
    • Author(s)
      Ninomiya, K., Kataoka, N. and Hagiwara, M
    • Journal Title

      Journal of Cell Biology

      Volume: 195 Pages: 27-40

    • Data Source
      KAKENHI-PROJECT-22603002

  • [Journal Article] Specific Y14 domains mediate its nucleo-cytoplasmic shuttling and association with spliced mRNA2011
    • Author(s)
      Kataoka N, Diem MD, Yoshida M, Hatai C, Dobashi I, Dreyfuss G, Hagiwara M, Ohno M
    • Journal Title

      Sci Rep

      Volume: 1:92

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21249013

  • [Journal Article] WT1 mutants reveal SRPK1 to be a downstream angiogenesis target by altering VEGF splicing2011
    • Author(s)
      Amin EM, Hua J, Cheung MK, Ni L, Kase S, Ren-nel ES, Gammons M, Nowak DG, Saleem MA, Hagiwara M, Schumacher VA, Harper SJ, Hinton D, Bates DO, Ladomery MR
    • Journal Title

      Cancer Cell

      Volume: 20 Pages: 768-780

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21249013

  • [Journal Article] Leucettines, a class of potent inhibitors of cdc2-like kinases and dual specificity, tyrosine phosphorylation regulated kinases derived from the marine sponge leucettamine B: modulation of alternative pre-RNA splicing.2011
    • Author(s)
      Debdab M, Carreaux F, Renault S, Soundararajan M, Fedorov O, Filippakopoulos P, Lozach O, Babault L, Tahtouh T, Baratte B, Ogawa Y, Hagiwara M, Eisenreich A, Rauch U, Knapp S, Meijer L, Bazureau JP
    • Journal Title

      J Med Chem.

      Volume: 54(12) Pages: 4172-4186

    • Data Source
      KAKENHI-PROJECT-21249013

  • [Journal Article] Stress-responsive maturation of Clk1/4 pre-mRNAs promotes phosphorylation of SR splicing factor2011
    • Author(s)
      Ninomiya K, Kataoka N, Hagiwara M
    • Journal Title

      J Cell Biol

      Volume: 195(1) Pages: 27-40

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21249013

  • [Journal Article] Leucettines, a class of potent inhibitors of cdc2-like kinases and dual specificity, tyrosine phosphorylation regulated kinases derived from the marine sponge leucettamine B : modulation of alternative pre-RNA splicing2011
    • Author(s)
      Debdab M, Carreaux F, Renault S, Soundararajan M, Fedorov O, Filippakopoulos P, Lozach O, Babault L, Tahtouh T, Baratte B, Ogawa Y, Hagiwara M, Eisenreich A, Rauch U, Knapp S, Meijer L, Bazureau JP
    • Journal Title

      J Med Chem

      Volume: 54(12) Pages: 4172-4186

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21249013

  • [Journal Article] RNAプロセシング異常 : RNA病を斬る2010
    • Author(s)
      萩原正敏
    • Journal Title

      細胞工学 Vol.29, No.2

    • Data Source
      KAKENHI-PROJECT-19390071

  • [Journal Article] RNAプロセシング異常:RNA病を斬る2010
    • Author(s)
      萩原正敏
    • Journal Title

      細胞工学 29(2)

      Pages: 126-130

    • Data Source
      KAKENHI-PROJECT-19390071

  • [Journal Article] RNA スプライシングの可視化による創薬スクリーニング2010
    • Author(s)
      野島孝之、萩原正敏
    • Journal Title

      細胞工学

      Volume: Vol.29, No.02 Pages: 175-180

    • Data Source
      KAKENHI-PROJECT-21249013

  • [Journal Article] Splicing reportermice revealed the evolutionally conserved switching mechanism of tissue-specific alternative splicing.2010
    • Author(s)
      Takeuchi A, Hosokawa M, Nojima T, Hagiwara M
    • Journal Title

      PLOS One

      Volume: 5

    • Data Source
      KAKENHI-PROJECT-21249013

  • [Journal Article] Splicing Reporter Mice Revealed the Evolutionally Conserved Switching Mechanism of Tissue-Specific Alternative Exon Selection2010
    • Author(s)
      Akihide Takeuchi, Motoyasu Hosokawa, Takayuki Nojima, Masatoshi Hagiwara
    • Journal Title

      PLoS One (accepted)

    • Data Source
      KAKENHI-PROJECT-19500269

  • [Journal Article] Visualization and genetic analysis ofalternative splicing regulation in vivo using fluorescence reporters in transgenic Caenorhabditis elegans.2010
    • Author(s)
      Kuroyanagi H, Ohno G, Sakane, H, Maruoka, H, and Hagiwara M
    • Journal Title

      Nature Protoc.

      Volume: 5 Pages: 1495-1517

    • Data Source
      KAKENHI-PROJECT-21249013

  • [Journal Article] Visualization and genetic analysis of alternative splicing regulation in vivo using fluorescence reporters in transgenic Caenorhabditis elegans2010
    • Author(s)
      Kuroyanagi H, Ohno G, Sakane, H, Maruoka, H, Hagiwara M
    • Journal Title

      Nature Protcol (in press)

    • Data Source
      KAKENHI-PROJECT-19390071

  • [Journal Article] RNA プロセシング異常RNA 病を斬る 基礎の基礎2010
    • Author(s)
      萩原正敏
    • Journal Title

      細胞工学

      Volume: Vol.29, No.02 Pages: 126-130

    • Data Source
      KAKENHI-PROJECT-21249013

  • [Journal Article] スプライシング制御機構の解明とその臨床応用2010
    • Author(s)
      萩原正敏
    • Journal Title

      メディカル・サイエンス・ダイジェスト

      Volume: Vol.36, No.13 Pages: 2-3

    • Data Source
      KAKENHI-PROJECT-21249013

  • [Journal Article] RNAプロセシング異常:RNA病を斬る2010
    • Author(s)
      萩原正敏
    • Journal Title

      細胞工学

      Volume: 29(2) Pages: 126-130

    • Data Source
      KAKENHI-PROJECT-21249013

  • [Journal Article] Regulation of vascular endothelial growth factor (VEGF) splicing from pro-angiogenic to anti-angiogenic isoforms-a novel therapeutic strategy for angiogenesis2010
    • Author(s)
      Nowak DG, Amin EM, Rennel ES, Hoareau-Aveilla C, Gammons M, Damodoran G, Hagiwara M, Harper SJ, Woolard J, Ladomery MR, Bates DO
    • Journal Title

      J.Biol.Chem. 285

      Pages: 5532-5540

    • Data Source
      KAKENHI-PROJECT-19390071

  • [Journal Article] RNAスプライシングの可視化による創薬スクリーニング2010
    • Author(s)
      野島孝之, 萩原正敏
    • Journal Title

      細胞工学 Vol.29, No.2

    • Data Source
      KAKENHI-PROJECT-19390071

  • [Journal Article] Splicing reporter mice revealed the evolutionally conserved switching mechanism of tissue-specific alternative exon selection2010
    • Author(s)
      Takeuchi A, Hosokawa M, Nojima T, Hagiwara M
    • Journal Title

      PLoS One

      Volume: 3;5(6)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21249013

  • [Journal Article] mRNAスプライシング制御から難治疾患の治療へ2009
    • Author(s)
      萩原正敏
    • Journal Title

      実験医学 27(17)

      Pages: 190-195

    • Data Source
      KAKENHI-PROJECT-19390071

  • [Journal Article] Akt2 regulation of Cdc2-like kinases (Clk/Sty), serine/arginine-rich (SR) protein phosphorylation, and insulin-induced alternative splicing of PKCssII mRNA2009
    • Author(s)
      Jiang K, Patel NA, Watson JE, Apostolatos H, Kleiman E, Hanson O, Hagiwara M, Cooper DR.
    • Journal Title

      Endocrinology

      Volume: 150(5) Pages: 2087-97

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21249013

  • [Journal Article] リン酸化依存的スプライシング制御機構2009
    • Author(s)
      萩原正敏
    • Journal Title

      蛋白質 核酸 酵素 54(16)

      Pages: 2055-2059

    • Data Source
      KAKENHI-PROJECT-19390071

  • [Journal Article] Herpesvirus protein ICP27 switches PML isoform by altering mRNA splicing2009
    • Author(s)
      Nojima T, Oshiro-Ideue T, Nakanoya H, Kawamura H, Morimoto M, Kawaguchi Y, Kataoka N, Hagiwara M
    • Journal Title

      Nucleic.Acids Res. 37(19)

      Pages: 6515-27

    • Data Source
      KAKENHI-PROJECT-19390071

  • [Journal Article] ウイルスによるスプライシング暗号の利用と撹乱2009
    • Author(s)
      萩原正敏, 野島孝之
    • Journal Title

      実験医学 増刊 Vol.27, No.10

    • Data Source
      KAKENHI-PROJECT-19390071

  • [Journal Article] Herpesvirus protein ICP27 switches PML isoform by altering mRNA splicing Nucleic.2009
    • Author(s)
      Nojima T, Oshiro-Ideue T, Nakanoya H, Kawamura H, Morimoto M, Kawaguchi Y, Kataoka N, Hagiwara M
    • Journal Title

      Acids Res

      Volume: 37(19) Pages: 6515-27

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21249013

  • [Journal Article] Akt2 regulation of Cdc2-like kinases (Clk/Sty), serine/arginine-rich (SR) protein phosphorylation, and insulin-induced alternative splicing of PKCssII mRNA2009
    • Author(s)
      Jiang K, Patel NA, Watson JE, Apostolatos H, Kleiman E, Hanson O, Hagiwara M, Cooper DR.
    • Journal Title

      Endocrinology 150(5)

      Pages: 2087-97

    • Data Source
      KAKENHI-PROJECT-19390071

  • [Journal Article] ウイルスによるスプライシング暗号の利用と撹乱2009
    • Author(s)
      萩原正敏、野島孝之
    • Journal Title

      実験医学

      Volume: 27(10) Pages: 42-47

    • Data Source
      KAKENHI-PROJECT-21249013

  • [Journal Article] Regulation of vascular endothelial growth factor (VEGF) splicing from pro-angiogenic to anti-angiogenic isoforms-a novel therapeutic strategy for angiogenesis2009
    • Author(s)
      Nowak DG, Amin EM, Rennel ES, Hoareau-Aveilla C, Gammons M, Damodoran G, Hagiwara M, Harper SJ, Woolard J, Ladomery MR, Bates DO.
    • Journal Title

      J.Biol.Chem

      Volume: 285 Pages: 5532-5540

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21249013

  • [Journal Article] mRNA スプライシング制御から難治疾患の治療へ2009
    • Author(s)
      萩原正敏
    • Journal Title

      実験医学

      Volume: Vol.27, No.17 Pages: 2870-2875

    • Data Source
      KAKENHI-PROJECT-21249013

  • [Journal Article] Regulation of vascular endothelial growth factor(VEGF)splicing from pro-angiogenic to anti-angiogenic isoforms-a novcl thcrapeutic strategy for angiogenesis2009
    • Author(s)
      Nowak DG, Amin EM, Rennel ES, Hoareau-Aveilla C, Gammons M, Damodoran G, Hagiwara M, Harper SJ, Woolard J, Ladomery MR, Bates DO.
    • Journal Title

      J.Biol.Chem (in press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390071

  • [Journal Article] Akt2 regulation of Cdc2-like kinases (Clk/Sty), serine/arginine-rich (SR) protein phosphorylation, and insulin-induced alternative splicing of PKCssII mRNA2009
    • Author(s)
      Jiang K, Patel NA, Watson JE, Apostolatos II, Kleiman E.Hanson O, Hagiwara M, Cooper DR.
    • Journal Title

      Endocrinology 150(5)

      Pages: 2087-97

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390071

  • [Journal Article] リン酸化依存的スプライシング制御機構2009
    • Author(s)
      萩原正敏
    • Journal Title

      蛋白質 核酸 酵素 Vol.54 No.16

    • Data Source
      KAKENHI-PROJECT-19390071

  • [Journal Article] Herpesvirus protein ICP27 switches PML isoform by altering mRNA splicing.2009
    • Author(s)
      Nojima T, Oshiro-Ideue T, Nakanoya H, Kawamura H, Morimoto M, Kawaguchi Y, Kataoka N and Hagiwara M
    • Journal Title

      Nucleic. Acids Res.

      Volume: 37 Pages: 6515-6527

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21249013

  • [Journal Article] mRNAスプライシング制御から難治疾患の治療へ2009
    • Author(s)
      萩原正敏
    • Journal Title

      実験医学

      Volume: 27(17) Pages: 190-195

    • Data Source
      KAKENHI-PROJECT-21249013

  • [Journal Article] Herpesvirus protcin ICP27 switches PML-isoform by altering mRNA splicing Nucleic2009
    • Author(s)
      Nojima T, Oshiro-Ideue T, Nakanoya H, Kawamura H, Morimo to M.Kawaguchi Y, Kataoka N, Hagiwara M
    • Journal Title

      Acids Res 37(19)

      Pages: 6515-27

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390071

  • [Journal Article] ウイルスによるスブライシング暗号の利用と撹乱2009
    • Author(s)
      萩原正敏、野島孝之
    • Journal Title

      実験医学 27(10)

      Pages: 42-47

    • Data Source
      KAKENHI-PROJECT-19390071

  • [Journal Article] リン酸化依存的スプライシング制御機構2009
    • Author(s)
      萩原正敏
    • Journal Title

      蛋白質 核酸 酵素

      Volume: 54(16) Pages: 2055-2059

    • Data Source
      KAKENHI-PROJECT-21249013

  • [Journal Article] 選択的スプライシングを生体内で可視化する2007
    • Author(s)
      黒柳秀人、萩原正敏
    • Journal Title

      細胞工学(CELL TECHNOLOGY) 26

      Pages: 64-65

    • Data Source
      KAKENHI-PROJECT-19390071

  • [Journal Article] キナーゼ阻害剤2007
    • Author(s)
      萩原正敏、臼木博一
    • Journal Title

      蛋白質 核酸 酵素 52(増刊号)

      Pages: 1708-1712

    • Data Source
      KAKENHI-PROJECT-19390071

  • [Journal Article] Effect of cisplatin treatment on speckled distribution of a serine/arg inine-rich nuclear protein CROP/Luc7A2007
    • Author(s)
      Umehara, H., Nishii, Y., Morishima, M., Kakehi, Y., Kioka, N., Amachi, T., Koizumi, J., Hagiwara, M. & Ueda, K.
    • Journal Title

      Biochem. Biophys. Res. Comm. 301

      Pages: 324-329

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14035102

  • [Journal Article] A novel histone-exchange factor, protein phosphatase 2Cγ, mediates the exchange and dephosphorylation of H2A/H2B.2006
    • Author(s)
      Kimura, H., Takizawa N., Allemand, E., Hori, T., Iborra, F. J., Nozaki, N., Muraki, M., Hagiwara, M., Krainer, A. R., Fukagawa, T., Okawa, K.
    • Journal Title

      J. Cell Biol. 175

      Pages: 389-400

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14035102

  • [Journal Article] A spliceosomal intron-binding protein, IBP160, links position-dependent assembly of intorn-encoded box C/C snoRNP to pre-mRNA splicing.2006
    • Author(s)
      Hirose T., Ideue, T., Nagai, M., Hagiwara. M., Shu, M., Steitz, J. A
    • Journal Title

      Mol. Cell 23(5)

      Pages: 673-684

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-14035102

  • [Journal Article] A molecular neuroethological approach for identifying and characterizing a cascade of behaviorally regulated genes.2006
    • Author(s)
      Wada, K., Howard, J. T., McConnell, P., Whitney, O., Lints, T., Rivas, M. V. Horita, H., Patterson, M. A., White, S. A., Scharff, C., Haesler, S., Zhao, S., Sakaguchi, H., Hagiwara, M.. Shiraki, T., Hirozane-Kishikawa, T., Skene, P., Hayashizaki, Y., Carninci, P., Jarvis, E. D.
    • Journal Title

      Proc Natl Acad Sci USA. 103(41)

      Pages: 15212-15217

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-14035102

  • [Journal Article] A molecular neuroethological approach for identifying and characterizing a cascade of behaviorally regulated genes.2006
    • Author(s)
      Wada, K., Howard, J. T., McConnell, P., Whitney, O., Lints, T., Rivas, M. V. Horita, H., Patterson, M. A., White, S. A., Scharff, C., Haesler, S., Zhao, S., Sakaguchi, H., Hagiwara, M., Shiraki, T., Hirozane-Kishikawa, T., Skene, P., Hayashizaki, Y., Carninci, P., Jarvis, E. D.
    • Journal Title

      Proc Natl Acad Sci USA. 103(41)

      Pages: 15212-15217

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14035102

  • [Journal Article] A novel histone・exchange factor, protein phosphatase 2C_y, mediates the exchange and dephosphorylation of H2A/H2B.2006
    • Author(s)
      Kimura, H., Takizawa N., Allem, E., Hori, T., Iborra, F. J., Nozaki, N., Muraki, M., Hagiwara, M. ., Krainer, A. R., Fukagawa, T., Okawa, K.
    • Journal Title

      J. Cell Biol. 175

      Pages: 389-400

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-14035102

  • [Journal Article] A transgenic reporter reveals cell-type-specific expression profiles and regulation mechanisms of alternatively-spliced exons in vivo.2006
    • Author(s)
      Kuroyanagi, H., Kobayashi, T., Mitani, S., Hagiwara, M.
    • Journal Title

      Nature Methods 3

      Pages: 909-915

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14035102

  • [Journal Article] Utilization of host SR protein kinases and RNA-splicing machinery during viral replication2006
    • Author(s)
      Fukuhara T, Hosoya T, Shimizu S, Sumi K, Oshiro T, Yoshinaka Y, Suzuki M, Yamamoto N, Herzenberg LA, Herzenberg LA, Hagiwara M
    • Journal Title

      Proc Natl Acad Sci USA 103(30)

      Pages: 11329-11333

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-14035102

  • [Journal Article] A transgenic reporter reveals cell-type-specific expression profiles and regulation mechanisms of alternatively-spliced exons in vivo.2006
    • Author(s)
      Kuroyanagi, H., Kobayashi, T., Mitani, S., Hagiwara. M.
    • Journal Title

      Nature Methods 3

      Pages: 909-915

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-14035102

  • [Journal Article] Utilization of host SR protein kinases and RNA-splicing machinery during viral replication.2006
    • Author(s)
      Fukuhara T, Hosoya T, Shimizu S, Sumi K, Oshiro T, Yoshinaka Y, Suzuki M, Yamamoto N, Herzenberg LA, Herzenberg LA, Hagiwara M
    • Journal Title

      Proc Natl Acad Sci USA. 103(30)

      Pages: 11329-11333

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14035102

  • [Journal Article] A spliceosomal intron-binding protein, IBP160, links position-dependent assembly of intorn-encoded box C/C snoRNP to pre-mRNA splicing.2006
    • Author(s)
      Hirose T., Ideue, T., Nagai, M., Hagiwara, M., Shu, M., Steitz, J. A.
    • Journal Title

      Mol. Cell. 23(5)

      Pages: 673-684

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14035102

  • [Journal Article] Alternative splicing : a new drug target of the post・genome era2005
    • Author(s)
      Hagiwara, M.
    • Journal Title

      Biochim Biophys Acta. 1754

      Pages: 324-331

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-14035102

  • [Journal Article] Bio-object, a stochastic simulator for post-transcriptional regulation.2005
    • Author(s)
      Ohki, N, Hagiwara. M
    • Journal Title

      Bioinformatics. 21

      Pages: 2478-2487

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-14035102

  • [Journal Article] Alternative splicing : a new drug target of the post-genome era.2005
    • Author(s)
      Hagiwara, M.
    • Journal Title

      Biochim Biophys Acta. 1754

      Pages: 324-331

    • Data Source
      KAKENHI-PROJECT-14035102

  • [Journal Article] Alternative splicing : a new drug target of the post-genome era.2005
    • Author(s)
      Hagiwara, M.
    • Journal Title

      Biochim Biophys Acta. 1754

      Pages: 324-331

    • Data Source
      KAKENHI-PROJECT-16390074

  • [Journal Article] Alternative splicing : a new drug target of the post-genome era.2005
    • Author(s)
      Hagiwara, M.
    • Journal Title

      Biochim Biophys Acta. 1754

      Pages: 324-331

    • Data Source
      KAKENHI-PROJECT-16017234

  • [Journal Article] Bio-object, a stochastic simulator for post-transcriptional regulation.2005
    • Author(s)
      Ohki, N, Hagiwara, M
    • Journal Title

      Bioinformatics 21

      Pages: 2478-2487

    • Data Source
      KAKENHI-PROJECT-16390074

  • [Journal Article] Alternative splicing : a new drug target of the post-genome era.2005
    • Author(s)
      Hagiwara M.
    • Journal Title

      Biochim Biophys Acta. 1754(1-2)

      Pages: 324-331

    • Data Source
      KAKENHI-PROJECT-17017016

  • [Journal Article] Bio-Object, a stochastic simulator for post-transcriptional regulation.2005
    • Author(s)
      Ohki, N., Hagiwara, M.
    • Journal Title

      Bioinformatics (in press)

    • Data Source
      KAKENHI-PROJECT-14035102

  • [Journal Article] Alternative splicing : a new drug target of the post-genome era2005
    • Author(s)
      Hagiwara, M.
    • Journal Title

      Biochim Biophys Acta. 1754

      Pages: 324-331

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14035102

  • [Journal Article] Bio-Object, a stochastic simulator for post-transcriptional regulation.2005
    • Author(s)
      Ohki, N., Hagiwara, M.
    • Journal Title

      Bioinformatics (in press)

    • Data Source
      KAKENHI-PROJECT-16390074

  • [Journal Article] Bio-Object, a stochastic simulator for post-transcriptional regulation.2005
    • Author(s)
      Ohki, N., Hagiwara, M.
    • Journal Title

      Bioinformatics 21

      Pages: 2478-2487

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14035102

  • [Journal Article] TNFα-induced ATF3 Expression Is Bidirectionally Regulated by the JNK and ERK Pathways in Vascular Endothelial Cells.2004
    • Author(s)
      Inoue, K., Zama, T., Kamimoto, T., Aoki, R., Ikeda, Y., Kimura, H., Hagiwara.M.
    • Journal Title

      Gene to Cells 1

      Pages: 59-70

    • Data Source
      KAKENHI-PROJECT-16390074

  • [Journal Article] Differential expression of glutamate receptors in avian neural pathways for learned vocalization.2004
    • Author(s)
      Wada, K., Sakaguchi, H., Jarvis, E., Hagiwara. M
    • Journal Title

      J. Comp. Neurol. 476

      Pages: 44-64

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-14035102

  • [Journal Article] Manipulation of alternative splicing by a newly developed inhibitor of Clks.2004
    • Author(s)
      Muraki, M., Ohkawara, B., Hosoya, T., Onogi, H., Koizumi, J., Koizumi, T., Sumi, K., Yomoda, J., Murray, M.V., Kimura, K., Furuichi, K., Shibuya, H., Krainer, A.R., Suzuki, M., Hagiwara, M.
    • Journal Title

      J.Biol.Chem. 279

      Pages: 24246-24254

    • Data Source
      KAKENHI-PROJECT-14035102

  • [Journal Article] Manipulation of alternative splicing by a newly developed inhibitor of Clks.2004
    • Author(s)
      Muraki, M., Ohkawara, B., Hosoya, T., Onogi, H., Koizumi, J., Koizumi, T., Sumi, K., Yomoda, J., Murray, M.V., Kimura, K., Furuichi, K., Shibuya, H., Krainer, A.R., Suzuki, M., Hagiwara.M.
    • Journal Title

      J.Biol.Chem. 279

      Pages: 24246-24254

    • Data Source
      KAKENHI-PROJECT-16390074

  • [Journal Article] TNFα-induced ATF3 Expression Is Bidirectionally Regulated by the JNK and ERK Pathways in Vascular Endothelial Cells.2004
    • Author(s)
      Inoue, K., Zama, T., Kamimoto, T., Aoki, R., Ikeda, Y., Kimura, H., Hagiwara, M.
    • Journal Title

      Gene to Cells. 1

      Pages: 59-70

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14035102

  • [Journal Article] Regulation of binding of lamin B receptor to chromatin by SR protein kinase and cdc2 kinase in Xenopus egg extracts2004
    • Author(s)
      Takano, M., Koyama, Y., Ito, H., Hoshino, S., Onogi, H., Hagiwara, M., Furukawa, K., Horigome, T
    • Journal Title

      J. Biol. Chem 279

      Pages: 13265-13271

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-14035102

  • [Journal Article] Regulation of binding of lamin B receptor to chromatin by SR protein kinase and cdc2 kinase in Xenopus egg extracts.2004
    • Author(s)
      Takano, M., Koyama, Y., Ito, H., Hoshino, S., Onogi, H., Hagiwara, M., Furukawa, K., Horigome, T
    • Journal Title

      J. Biol. Chem. 279

      Pages: 13265-13271

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14035102

  • [Journal Article] Differential expression of glutamate receptors in avian neural pathways for learned vocalization.2004
    • Author(s)
      Wada, K., Sakaguchi, H., Jarvis, E., Hagiwara.M.
    • Journal Title

      J.Comp.Neurol. 476

      Pages: 44-64

    • Data Source
      KAKENHI-PROJECT-16390074

  • [Journal Article] Regulation of binding of lamin B receptor to chromatin by SR protein kinase and cdc2 kinase in Xenopus egg extracts.2004
    • Author(s)
      Takano, M., Koyama, Y., Ito, H., Hoshino, S., Onogi, H., Hagiwara, M.
    • Journal Title

      J.Biol.Chem. 279

      Pages: 13265-13271

    • Data Source
      KAKENHI-PROJECT-14035102

  • [Journal Article] Manipulation of alternative splicing by a newly developed inhibitor of Clks.2004
    • Author(s)
      Muraki, M., Ohkawara, B., Hosoya, T., Onogi, H., Koizumi, J., Koizumi, T., Sumi, K., Yomoda, J., Murray, M. V., Kimura, K., Furuichi, K., Shibuya, H., Krainer, A. R., Suzuki, M. Hagiwara, M.
    • Journal Title

      J. Biol. Chem. 279

      Pages: 24246-24254

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14035102

  • [Journal Article] TNFα-induced ATF3 Expression Is Bidirectionally Regulated by the JNK and ERK Pathways in Vascular Endothelial Cells.2004
    • Author(s)
      Inoue, K., Zama, T., Kamimoto, T., Aoki, R., Ikeda, Y., Kimura, H., Hagiwara, M.
    • Journal Title

      Gene to Cells 1

      Pages: 59-70

    • Data Source
      KAKENHI-PROJECT-14035102

  • [Journal Article] Manipulation of alteRNAtive splicing by a newly developed inhibitor of Clks2004
    • Author(s)
      Muraki, M., Ohkawara, B., Hosoya, T., Onogi, H., Koizumi, J., Koizumi, T., Sumi, K., Yomoda, J., Murray, M. V., Kimura, K., Furuichi, K., Shibuya, H., Krainer, A. R., Suzuki, M., Hagiwara, M
    • Journal Title

      J. Biol. Chem 279

      Pages: 24246-24254

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-14035102

  • [Journal Article] Differential expression of glutamate receptors in avian neural pathways for learned vocalization.2004
    • Author(s)
      Wada, K., Sakaguchi, H., Jarvis, E., Hagiwara, M.
    • Journal Title

      J.Comp.Neurol. 476

      Pages: 44-64

    • Data Source
      KAKENHI-PROJECT-14035102

  • [Journal Article] Differential expression of glutamate receptors in avian neural pathways for learned vocalization.2004
    • Author(s)
      Wada, K., Sakaguchi, H., Jarvis, E., Hagiwara, M.
    • Journal Title

      J. Comp. Neurol. 476

      Pages: 44-64

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14035102

  • [Journal Article] TNFα-induced ATF3 Expression Is Bidirectionally Regulated by the JNK and ERK Pathways in Vascular Endothelial Cells2004
    • Author(s)
      Inoue, K., Zama, T., Kamimoto, T., Aoki, R., Ikeda, Y., Kimura, H. & Hagiwara, M.
    • Journal Title

      Gene to Cells 1

      Pages: 59-70

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-14035102

  • [Journal Article] Regulation of binding of lamin B receptor to chromatin by SR protein kinase and cdc2 kinase in Xenopus egg extracts.2004
    • Author(s)
      Takano, M., Koyama, Y., Ito, H., Hoshino, S., Onogi, H., Hagiwara.M..Furukawa, K., Horigome, T
    • Journal Title

      J.Biol.Chem. 279

      Pages: 13265-13271

    • Data Source
      KAKENHI-PROJECT-16390074

  • [Journal Article] Novel SR-related protein Clasp specifically interacts with inactivated Clk4 and induces the exon EB inclusion of Clk.2003
    • Author(s)
      Katsu, R., Onogi, H., Wada, K., Kawaguchi, K., & Hagiwara. M
    • Journal Title

      J. Biol. Chem 277

      Pages: 44220-44228

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-14035102

  • [Journal Article] Involvement of MKK6 in TCRa beta(int)CD69(lo) : a target population for apoptotic cell death in thymocytes.2003
    • Author(s)
      Suzuki, H., Wu, JH, Hossain, K., Ohhata, T., Du, J., Akhand, AA., Hayakawa, A., Kimura, H., Hagiwara, M., Nakashima, I.
    • Journal Title

      FASEB J. 1538

      Pages: 17-40

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14035102

  • [Journal Article] Involvement of MKK6 in TCRa beta(int)CD69(lo) : a target population forapoptotic cell death in thymocytes2003
    • Author(s)
      Suzuki, H., Wu, JH, Hossain, K., Ohhata, T., Du, J., Akhand, AA., Hayakawa, A., Kimura, H., Hagiwara, M., Nakashima, I
    • Journal Title

      FASEB J 17

      Pages: 1538-40

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-14035102

  • [Journal Article] Effect of cisplatin treatment on speckled distribution of a serine/arginine-rich nuclear proteinCROP/Luc7A2003
    • Author(s)
      Umehara, H., Nishii, Y., Morishima, M., Kakehi, Y., Kioka, N., Amachi, T., Koizumi, J., Hagiwara, M. & Ueda, K
    • Journal Title

      Biochem. Biophys. Res. Comm. 301

      Pages: 324-329

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-14035102

  • [Journal Article] A novel dual-specificity phosphatase SKRP1 interacts with the MAPKK MKK7 and inactivates the JNK MAPK pathway : Implication for the precise regulation of the particular MAPK pathway.2002
    • Author(s)
      Zama, Z., Aoki, R., Kamimoto, T., Inoue, K., Ikeda, Y., Hagiwara M.
    • Journal Title

      J. Biol. Chem. 277 277

      Pages: 23909-23918

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14035102

  • [Journal Article] Scaffold role of a MAP linase phosphatase, SKRPl for the JNK signaling pathway・2002
    • Author(s)
      Zama, Z., Aoki, R., Kamimoto, T., Inoue, K., Ikeda, Y. & Hagiwara M.
    • Journal Title

      J. Biol. Chem 277

      Pages: 23919-23926

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-14035102

  • [Journal Article] Identification of methylated protein arginine N-methyltransferase 1, PRMT1 with a new express ion cloning strategy2002
    • Author(s)
      Wada, K., Inoue, K, & Hagiwara. M.
    • Journal Title

      Biochem. Biophys. Acta. 1591

      Pages: 1-10

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-14035102

  • [Journal Article] Identification of ATF-2 as a Transcriptional Regulator for the Tyrosine Hydroxylase Gene2002
    • Author(s)
      Suzuki, T., Yamakuni, T., Hagiwara. M., & Ichinose, H
    • Journal Title

      J. Biol. Chem 277

      Pages: 40768-40774

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-14035102

  • [Journal Article] Identification of methylated protein arginine N-methyltransferase 1, PRMT1 with a new expression cloning strategy.2002
    • Author(s)
      Wada, K., Inoue, K., Hagiwara, M.
    • Journal Title

      Biochem. Biophys. Acta. 1591

      Pages: 1-10

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14035102

  • [Journal Article] CaMK cascade activates CRE-mediated transcription in neurons of Caenorhabditis elegans2002
    • Author(s)
      Kimura, Y., Corcoran, E. E., Eto K., Gengyo-Ando, K., Muramatsu, M., Kobayashi, R., Freedman, J H., Mitani, S., Hagiwara. M., Means, A. R., & Tokumitsu H
    • Journal Title

      EMBO Rep 3

      Pages: 962-966

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-14035102

  • [Journal Article] M-kinase cascade activates CRE-mediated transcription Identification of ATF2.2002
    • Author(s)
      Suzuki, T., Yamakuni, T., Hagiwara, M., Ichinose, H.
    • Journal Title

      J. Biol. Chem. (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14035102

  • [Journal Article] M-kinase cascade activates CRE-mediated transcription in neurons of Caenorhabditis elegans2002
    • Author(s)
      Kimura, Y., Corcoran, E. E., Eto K., Gengyo-Ando, K., Muramatsu, M., Kobayashi, R., Freedman, J. H., Mitani, S., Hagiwara, M., Means, A. R., Tokumitsu H.
    • Journal Title

      EMBO Rep. (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14035102

  • [Journal Article] Novel SR-related protein Clasp specifically interacts with inactivated Clk4 and induces the exon EB inclusion of Clk.2002
    • Author(s)
      Katsu, R., Onogi, H., Wada, K., Kawaguchi, K., Hagiwara, M.
    • Journal Title

      J. Biol. Chem. 277

      Pages: 44220-44228

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14035102

  • [Journal Article] Identification of methylated protein arginine N-methyltransferase 1, PRMT1 with a new expression cloning strategy.2002
    • Author(s)
      Kazuhiro, W, Koichi, I, Hagiwara, M.
    • Journal Title

      Biochem. Biophys. Acta. 1591

      Pages: 1-10

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14035102

  • [Journal Article] A novel dual-specificity phosphatase SKRP1 interacts with the MAPKKMKK7 and inactivates the JNK MAPK pathway : Implication for the precise regulation of the particular MAPK pathway2002
    • Author(s)
      Zama, Z., Aoki, R., Kamimoto, T., Inoue, K., Ikeda, Y. & Hagiwara M.
    • Journal Title

      J. Biol. Chem 277

      Pages: 23909-23918

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-14035102

  • [Journal Article] Scaffold role of a MAP linase phosphatase, SKRP1 for the JNK signaling pathway.2002
    • Author(s)
      Zama, Z., Aoki, R., Kamimoto, T., Inoue, K., Ikeda, Y., Hagiwara M.
    • Journal Title

      J. Biol. Chem. 277

      Pages: 23919-23926

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14035102

  • [Patent] スプライシング制御化合物による腫瘍免疫原性の向上2021
    • Inventor(s)
      萩原正敏　網代将彦　松島慎吾
    • Industrial Property Rights Holder
      萩原正敏　網代将彦　松島慎吾
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2021-144961
    • Filing Date
      2021
    • Data Source
      KAKENHI-PROJECT-21H05042

  • [Patent] Molecules, method for screening molecules as medicines for family dysautonomia2016
    • Inventor(s)
      萩原正敏、吉田優、細谷孝充
    • Industrial Property Rights Holder
      萩原正敏、吉田優、細谷孝充
    • Industrial Property Rights Type
      特許
    • Filing Date
      2016
    • Acquisition Date
      2018
    • Overseas
    • Data Source
      KAKENHI-PROJECT-15H05721

  • [Patent] Molecules, method for screening molecules as medicines for familial dysautonomia2016
    • Inventor(s)
      萩原正敏、吉田優、細谷孝充
    • Industrial Property Rights Holder
      萩原正敏、吉田優、細谷孝充
    • Industrial Property Rights Type
      特許
    • Filing Date
      2016-01-14
    • Overseas
    • Data Source
      KAKENHI-PROJECT-15H05721

  • [Patent] Prophylactic or ameliorating agent for genetic diseases2015
    • Inventor(s)
      萩原正敏、片岡直行、松尾雅文、西田篤史
    • Industrial Property Rights Holder
      萩原正敏、片岡直行、松尾雅文、西田篤史
    • Industrial Property Rights Type
      特許
    • Filing Date
      2015-04-01
    • Acquisition Date
      2016-01-26
    • Overseas
    • Data Source
      KAKENHI-PROJECT-15H05721

  • [Patent] Transgenic reporter system that reveals expression profiles and regulation mechanisms of alternative splicing in mammalian organisms.2015
    • Inventor(s)
      萩原正敏、武内彰英
    • Industrial Property Rights Holder
      萩原正敏、武内彰英
    • Industrial Property Rights Type
      特許
    • Filing Date
      2015-04-01
    • Acquisition Date
      2016-01-29
    • Data Source
      KAKENHI-PROJECT-15H05721

  • [Patent] 疼痛に関する化合物及び医薬組成物2014
    • Inventor(s)
      萩原正敏、豊本雅靖、細谷孝充、吉田優、栗原崇
    • Industrial Property Rights Holder
      京都大学、東京医科歯科大学、鹿児島大学
    • Industrial Property Rights Type
      特許
    • Filing Date
      2014-12-18
    • Overseas
    • Data Source
      KAKENHI-PROJECT-25460723

  • [Patent] Molecules, method for screening molecules that stabilize and/or destabilize proteins, and method for detecting protein activity2013
    • Inventor(s)
      萩原正敏、喜井勲、細谷孝充、吉田優
    • Industrial Property Rights Holder
      萩原正敏、喜井勲、細谷孝充、吉田優
    • Industrial Property Rights Type
      特許
    • Filing Date
      2013-06-06
    • Overseas
    • Data Source
      KAKENHI-PROJECT-24241076

  • [Patent] 疼痛に関する化合物及び医薬組成物2013
    • Inventor(s)
      萩原正敏、豊本雅靖、細谷孝充、吉田優、栗原崇
    • Industrial Property Rights Holder
      京都大学、東京医科歯科大学、鹿児島大学
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2013-261396
    • Filing Date
      2013-12-18
    • Data Source
      KAKENHI-PROJECT-25460723

  • [Patent] スクリーニング方法、タンパク質の不安定性及び/又は安定性を誘導する物質、及び、タンパク質の活性評価2012
    • Inventor(s)
      萩原正敏、喜井勲、細谷孝充、隅田有人、吉田優
    • Industrial Property Rights Holder
      萩原正敏、喜井勲、細谷孝充、隅田有人、吉田優
    • Industrial Property Rights Type
      特許
    • Filing Date
      2012-06-06
    • Data Source
      KAKENHI-PROJECT-24241076

  • [Patent] Transgenic reporter system that reveals expression profile and regulation mechanisms of alternative splicing in mammalian organisms2011
    • Inventor(s)
      萩原正敏、武内章英
    • Industrial Property Rights Holder
      萩原正敏、武内章英
    • Filing Date
      2011-05-31
    • Acquisition Date
      2016-01-29
    • Description
      9,273,364(US) 2576778(EP) 2012.11.29(US) 2013.1.1(EP) 2016.3.1(US) 2017.8.9(EP)
    • Data Source
      KAKENHI-PROJECT-21249013

  • [Patent] Transgenic reporter system that reveals expression profiles and regulation mechanisms of alternative splicing in mammalian organisms2011
    • Inventor(s)
      萩原正敏、武内章英
    • Industrial Property Rights Holder
      萩原正敏、武内章英
    • Filing Date
      2011-05-31
    • Overseas
    • Data Source
      KAKENHI-PROJECT-21249013

  • [Patent] 遺伝性疾患の予防・改善剤2011
    • Inventor(s)
      萩原正敏、片岡直行、松尾雅文、西田篤史
    • Industrial Property Rights Holder
      萩原正敏、片岡直行、松尾雅文、西田篤史
    • Industrial Property Number
      2010-146699
    • Filing Date
      2011-06-27
    • Data Source
      KAKENHI-PROJECT-21249013

  • [Patent] Transgenic reporter system that reveals expression profile and regulation mechanisms of alternative splicing in mammalian organisms2011
    • Inventor(s)
      萩原正敏、武内章英
    • Industrial Property Rights Holder
      萩原正敏、武内章英
    • Filing Date
      2011-05-31
    • Description
      US.61/350,420 2010年6月1日(米国)
    • Overseas
    • Data Source
      KAKENHI-PROJECT-21249013

  • [Patent] 遺伝性疾患の予防・改善剤2011
    • Inventor(s)
      萩原正敏、片岡直行、松尾雅文、西田篤史
    • Industrial Property Rights Holder
      国立大学法人神戸大学 国立大学法人東京医科歯科大学
    • Industrial Property Number
      2010-146699
    • Filing Date
      2011-06-27
    • Data Source
      KAKENHI-PROJECT-22603002

  • [Patent] 遺伝性疾患の予防・改善剤2010
    • Inventor(s)
      萩原正敏、片岡直行、松尾雅文、西田篤史
    • Industrial Property Rights Holder
      国立大学法人東京医科歯科大学、国立大学法人神戸大学
    • Industrial Property Number
      2010-014669
    • Filing Date
      2010-06-28
    • Data Source
      KAKENHI-PROJECT-22603002

  • [Patent] Transgenic reporter system that reveals expression profiles and regulation mechanisms of alternative splicing in mammalian organisms2010
    • Inventor(s)
      萩原正敏, 武内章英
    • Industrial Property Rights Holder
      萩原正敏, 武内章英
    • Filing Date
      2010
    • Overseas
    • Data Source
      KAKENHI-PROJECT-21249013

  • [Patent] DYRK を阻害するベンゾチアゾール誘導体を含有する医薬組成物2009
    • Inventor(s)
      萩原正敏, 野中洋介, 土橋圭子, 吉田実代, 平松俊行
    • Industrial Property Rights Holder
      株式会社キノファーマ
    • Industrial Property Number
      2009-038327
    • Filing Date
      2009-02-20
    • Data Source
      KAKENHI-PROJECT-19390071

  • [Patent] 抗RNAウイルス作用を有するアニリン誘導体2008
    • Inventor(s)
      萩原正敏, 小野木博, 鈴木正昭
    • Industrial Property Rights Holder
      株式会社キノファーマ
    • Industrial Property Number
      2008-078728
    • Filing Date
      2008-03-25
    • Data Source
      KAKENHI-PROJECT-19390071

  • [Patent] 発光タンパク質を用いたリン酸化酵素阻害物質のスクリーニング方法2008
    • Inventor(s)
      萩原正敏, 野村奈美子, 木村広, 野崎直仁
    • Industrial Property Rights Holder
      株式会社キノファーマ
    • Industrial Property Number
      2008-053502
    • Filing Date
      2008-03-04
    • Data Source
      KAKENHI-PROJECT-19390071

  • [Patent] DYRK を阻害するベンゾチアゾール誘導体を含有する医薬組成物2008
    • Inventor(s)
      萩原 正敏, 澁谷 浩司, 大西 英理子, 小川 靖
    • Industrial Property Rights Holder
      株式会社キノファーマ
    • Industrial Property Number
      2008-190277
    • Filing Date
      2008-07-23
    • Data Source
      KAKENHI-PROJECT-19390071

  • [Patent] 抗ウイルス作用を有するアニリン誘導体2008
    • Inventor(s)
      萩原正敏、小野木博、鈴木正昭
    • Industrial Property Rights Holder
      萩原正敏、小野木博、鈴木正昭
    • Industrial Property Number
      2008-078728
    • Acquisition Date
      2008-03-25
    • Data Source
      KAKENHI-PROJECT-19041027

  • [Patent] 発光タンパク質を用いたリン酸化酵素阻害物質のスクリーニング方法2008
    • Inventor(s)
      萩原正敏、野村奈美子、木村広、野崎直仁
    • Industrial Property Rights Holder
      萩原正敏、野村奈美子、木村広、野崎直仁
    • Industrial Property Number
      2008-053502
    • Acquisition Date
      2008-03-04
    • Data Source
      KAKENHI-PROJECT-19041027

  • [Patent] 抗ウイルス作用を有するアニリン誘導体2007
    • Inventor(s)
      萩原正敏、小野木博
    • Industrial Property Rights Holder
      萩原正敏、小野木博
    • Filing Date
      2007-08-03
    • Data Source
      KAKENHI-PROJECT-19041027

  • [Patent] 抗ウイルス作用を有するアニリン誘導体2007
    • Inventor(s)
      萩原正敏、小野木博、鈴木正昭
    • Industrial Property Rights Holder
      萩原正敏、小野木博、鈴木正昭
    • Filing Date
      2007-04-25
    • Data Source
      KAKENHI-PROJECT-19041027

  • [Patent] 生体内における選択的スプライシングレポーター系2006
    • Inventor(s)
      萩原正敏, 黒柳秀人
    • Industrial Property Rights Holder
      国立大学法人東京医科歯科大学
    • Filing Date
      2006-09-26
    • Description
      「研究成果報告書概要(和文)」より
    • Overseas
    • Data Source
      KAKENHI-PROJECT-14035102

  • [Patent] A Transgenic Reporter System that Reveals Expression Profiles and Regulation Mechanisms of Alternative Splicing in Living Organisms2006
    • Inventor(s)
      Hidehito Kuroyanagi, Masatoshi Hagiwara
    • Industrial Property Rights Holder
      Hidehito Kuroyanagi, Masatoshi Hagiwara
    • Filing Date
      2006-09-27
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16390074

  • [Patent] 異常スプライシング関連疾患の治療薬候補物質2005
    • Inventor(s)
      萩原正敏, 鈴木正昭
    • Industrial Property Rights Holder
      国立大学法人東京医科歯科大学
    • Filing Date
      2005
    • Description
      「研究成果報告書概要(和文)」より
    • Overseas
    • Data Source
      KAKENHI-PROJECT-14035102

  • [Patent] SR蛋白質のリン酸化制御方法、およびSR蛋白質の活性制御剤を有効成分とする抗ウイルス剤2003
    • Inventor(s)
      萩原正敏, 福原武志, 鈴木正昭, 細谷孝充
    • Industrial Property Rights Holder
      萩原正敏
    • Industrial Property Number
      2003-435085
    • Filing Date
      2003
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14035102

  • [Presentation] 小さなことから世界を変えよう！京都大学発スタートアップ企業を育てるオリジナルメソッド」（A World Revolution from Small Things: Original Methods for Start-ups from Kyoto University）2021
    • Author(s)
      萩原正敏
    • Organizer
      ウェブセミナー「京都大学からの提言」第5回
    • Invited
    • Data Source
      KAKENHI-PROJECT-21H05042

  • [Presentation] Splicing therapy for inherited heart diseases2021
    • Author(s)
      萩原正敏
    • Organizer
      BI × Scientific Hour 『Drug Discovery Beyond Borders: Intractable Diseases related to Muscle, Bone and Cartilage』
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21H05042

  • [Presentation] Future Forum- Looking towards the next decade of chemical biology2021
    • Author(s)
      萩原正敏
    • Organizer
      International Chemical Biology Society 2021
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21H05042

  • [Presentation] 人工知能と化学的介入によるスプライシングコード解読から深部イントロンのVUS解明へ2021
    • Author(s)
      萩原正敏
    • Organizer
      第48回日本毒性学会学術年会
    • Invited
    • Data Source
      KAKENHI-PROJECT-21H05042

  • [Presentation] RNAを標的としたアカデミア創薬2020
    • Author(s)
      萩原正敏
    • Organizer
      医療産業イノベーションフォーラム
    • Invited
    • Data Source
      KAKENHI-PROJECT-15H05721

  • [Presentation] 人工知能を活用した偽エクソン型スプライス異常の包括的解析と創薬標的としての評価2020
    • Author(s)
      萩原正敏
    • Organizer
      第47回日本毒性学会学術年会
    • Invited
    • Data Source
      KAKENHI-PROJECT-15H05721

  • [Presentation] Neurogenesis induction therapy normalizes brain structure and functions in Down syndrome mice.2020
    • Author(s)
      Akiko Nakano-Kobayashi and Masatoshi Hagiwara
    • Organizer
      第13回成体脳ニューロン新生懇談会「個性」創発脳共催研究会
    • Data Source
      KAKENHI-PROJECT-15H05721

  • [Presentation] Splicing therapy for inherited heart diseases2020
    • Author(s)
      萩原正敏
    • Organizer
      第84回日本循環器学会学術集会(APSC2020との合同開催）
    • Invited
    • Data Source
      KAKENHI-PROJECT-15H05721

  • [Presentation] スプライシング治療薬による遺伝病治療の試み2020
    • Author(s)
      萩原正敏
    • Organizer
      第45回日本医用マススペクトル学会
    • Invited
    • Data Source
      KAKENHI-PROJECT-15H05721

  • [Presentation] トランスクリプトームを低分子で操作して難病を治す2020
    • Author(s)
      萩原正敏
    • Organizer
      第9回生命医薬情報学連合大会（日本バイオインフォマティクス学会年会）
    • Invited
    • Data Source
      KAKENHI-PROJECT-15H05721

  • [Presentation] The Impossible Dream. 見果てぬ夢を追いかけて～魔法の弾丸を求める旅～2019
    • Author(s)
      萩原正敏
    • Organizer
      平成31年三医会関西支部総会・講演会
    • Invited
    • Data Source
      KAKENHI-PROJECT-15H05721

  • [Presentation] RNAバイオロジー + ケミカルバイオロジー = 画期的アカデミア創薬2019
    • Author(s)
      萩原正敏
    • Organizer
      第80回分子生命科学セミナー／大学院特別講義
    • Invited
    • Data Source
      KAKENHI-PROJECT-15H05721

  • [Presentation] Epigenetic Modifications in Chronic Pathology and Toxicology2019
    • Author(s)
      Masatoshi Hagiwara
    • Organizer
      SOT 58th Annual Meeting and ToxExpo
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H05721

  • [Presentation] スプライシング異常を伴う遺伝病とその新しい治療薬2019
    • Author(s)
      萩原正敏
    • Organizer
      第41回日本小児遺伝学会学術集会
    • Invited
    • Data Source
      KAKENHI-PROJECT-15H05721

  • [Presentation] Oncogenic role of splicing factor SRSF3 through ILF3 and targeting SR protein function by CLK inhibitor.2019
    • Author(s)
      Masahiko Ajiro and Hagiwara Masatoshi
    • Organizer
      第78回日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-15H05721

  • [Presentation] Integrative epigenomic and transcriptomic study of Williams syndrome2019
    • Author(s)
      Masatoshi Hagiwara
    • Organizer
      International Symposium on Epigenome 2019 (Development of fundamental technologies for diagnosis and therapy based upon epigenome analysis)
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H05721

  • [Presentation] 低分子化合物でRNA発現や幹細胞増殖をそうやして難病を治そう！2019
    • Author(s)
      萩原正敏
    • Organizer
      第18回日本再生医療学会総会
    • Invited
    • Data Source
      KAKENHI-PROJECT-15H05721

  • [Presentation] 先天性神経疾患を標的としたRNA創薬2018
    • Author(s)
      萩原正敏
    • Organizer
      第41回日本神経科学大会
    • Invited
    • Data Source
      KAKENHI-PROJECT-15H05721

  • [Presentation] 希少疾患に対するアカデミア創薬の実現2018
    • Author(s)
      萩原正敏
    • Organizer
      ECC-iCAP ～科学のフロントランナーが語る未来世界～
    • Invited
    • Data Source
      KAKENHI-PROJECT-15H05721

  • [Presentation] RNAスプライシング操作薬の標的となり得る遺伝性難病について2018
    • Author(s)
      萩原正敏
    • Organizer
      医療ビッグデータ・コンソーシアム　第4回ライフサイエンス部会
    • Invited
    • Data Source
      KAKENHI-PROJECT-15H05721

  • [Presentation] pre-mRNAスプライシングを低分子化合物で操作して遺伝病を治そう！2018
    • Author(s)
      萩原正敏
    • Organizer
      第399回CBI学会講演会
    • Invited
    • Data Source
      KAKENHI-PROJECT-15H05721

  • [Presentation] pre-mRNAスプライシングを低分子化合物で操作して遺伝病を治そう2018
    • Author(s)
      萩原正敏
    • Organizer
      第91回日本生化学会大会
    • Invited
    • Data Source
      KAKENHI-PROJECT-15H05721

  • [Presentation] New therapeutics targeting transcription RNA processing w small molecules2018
    • Author(s)
      Masatoshi Hagiwara
    • Organizer
      Marc Montminy’s 62nd Birthday Symposium
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H05721

  • [Presentation] エピゲノム創薬で治療可能な難病について」2018
    • Author(s)
      萩原正敏
    • Organizer
      AMRF-CREST【エピゲノム】領域会議
    • Place of Presentation
      宮城
    • Year and Date
      2018-02-09
    • Data Source
      KAKENHI-PROJECT-21249013

  • [Presentation] RNAを標的としたアカデミア創薬2018
    • Author(s)
      萩原正敏
    • Organizer
      第9回新たな創薬パラダイムの創出
    • Place of Presentation
      東京
    • Year and Date
      2018-01-12
    • Data Source
      KAKENHI-PROJECT-21249013

  • [Presentation] Academia drug discovery with novel strategies of chemical biology.2018
    • Author(s)
      Masatoshi Hagiwara
    • Organizer
      International Chemical Biology Society.
    • Place of Presentation
      China-Shanghai
    • Year and Date
      2018-10-17
    • Data Source
      KAKENHI-PROJECT-21249013

  • [Presentation] Forward Drug Discovery : 表現型スクリーニングから創薬標的の同定へ2018
    • Author(s)
      萩原正敏
    • Organizer
      京都府京大オフィス産学連携セミナー～創薬・医療技術の現場から～
    • Place of Presentation
      京都
    • Year and Date
      2018-03-14
    • Data Source
      KAKENHI-PROJECT-21249013

  • [Presentation] 京大におけるワンストップ創薬の実現に向けて2018
    • Author(s)
      萩原正敏
    • Organizer
      IHK　2018年度　産学連携セミナー　Building a New Open Innovation Ecosystem for Medical Research and Drug Discovery
    • Invited
    • Data Source
      KAKENHI-PROJECT-15H05721

  • [Presentation] 京都大学医学研究科のセレンディピティーを活用したワンストップ創薬2018
    • Author(s)
      萩原正敏
    • Organizer
      イノベーションハブ京都　開設１周年記念シンポジウム　アカデミアからスタとアップへ！～イノベーションの創出とその育成～
    • Invited
    • Data Source
      KAKENHI-PROJECT-15H05721

  • [Presentation] The Impossible Dream to Make "Magic Bullets"2018
    • Author(s)
      Masatoshi Hagiwara
    • Organizer
      WCP 2018 KYOTO 18th World Congress of Basic and Clinical Pharmacology (11th Ebashi Setsuro Award Lecture)
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H05721

  • [Presentation] 小分子化合物の新しい可能性 : 遺伝病治療や再生医療の実現に向けて2018
    • Author(s)
      萩原正敏
    • Organizer
      日本農芸化学会2018年度大会 学術活動強化委員会企画シンポジウム～ケミカルバイオロジー研究の最前線～
    • Place of Presentation
      名古屋
    • Year and Date
      2018-03-16
    • Data Source
      KAKENHI-PROJECT-21249013

  • [Presentation] Drug Discovery from Transcriptome Analysis and Manipulation2018
    • Author(s)
      Masatoshi Hagiwara
    • Organizer
      UCSD School of Medicine Department of Pharmacology Seminar
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H05721

  • [Presentation] Genetic diseases caused by aberrant splicing and their therapeutics2018
    • Author(s)
      Masatoshi Hagiwara
    • Organizer
      The 6th Kyoto International Symposium on Genomic Medicine - International Symposium on Disease Genomics
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H05721

  • [Presentation] The Impossible Dream（見果てぬ夢）2018
    • Author(s)
      萩原正敏
    • Organizer
      三重県立四日市高等学校SGH講演会
    • Invited
    • Data Source
      KAKENHI-PROJECT-15H05721

  • [Presentation] トランスクリプトーム創薬の試み2018
    • Author(s)
      萩原正敏
    • Organizer
      第45回日本毒性学会学術年会
    • Invited
    • Data Source
      KAKENHI-PROJECT-15H05721

  • [Presentation] 遺伝病治療に向けて低分子化合物でpre-mRNAスプライシングを操作する2018
    • Author(s)
      萩原正敏
    • Organizer
      第41回ケモインフォマティクス討論会
    • Invited
    • Data Source
      KAKENHI-PROJECT-15H05721

  • [Presentation] Drug Development for Cardiac Fabry Disease2018
    • Author(s)
      Masatoshi Hagiwara
    • Organizer
      18th World Congress of Basic and Clinical Pharmacology
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H05721

  • [Presentation] RNAバイオロジー + ケミカルバイオロジー = 創薬2018
    • Author(s)
      萩原正敏
    • Organizer
      第41回日本分子生物学会年会
    • Invited
    • Data Source
      KAKENHI-PROJECT-15H05721

  • [Presentation] Splicing Therapy for Cardiac Fabry Disease2018
    • Author(s)
      Masatoshi Hagiwara
    • Organizer
      Cold Spring Harbor Asia Meeting RNA Biology
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H05721

  • [Presentation] オープンイノベーションによるアカデミア創薬のワンストップ拠点構想2018
    • Author(s)
      萩原正敏
    • Organizer
      文部科学省科学技術・学術審議会研究計画・評価分科会　ライフサイエンス委員会　創薬研究戦略作業部会
    • Invited
    • Data Source
      KAKENHI-PROJECT-15H05721

  • [Presentation] 脳・生体イメージングの創薬への展開2017
    • Author(s)
      萩原正敏
    • Organizer
      シンポジウム「健康社会にむけた多次元脳・生体イメージングの総合的推進」
    • Place of Presentation
      東京
    • Year and Date
      2017-01-22
    • Data Source
      KAKENHI-PROJECT-21249013

  • [Presentation] 京都大学におけるアカデミア創薬の試み2017
    • Author(s)
      萩原正敏
    • Organizer
      公益社団法人 先端医療振興財団での講演会
    • Place of Presentation
      神戸
    • Year and Date
      2017-01-10
    • Data Source
      KAKENHI-PROJECT-21249013

  • [Presentation] Chemical therapeutics of congenital diseases by manipulating transcriptome.2017
    • Author(s)
      Masatoshi Hagiwara
    • Organizer
      Cutting Edge Developments in RNA Biology for the Control of Gene Expression
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H05721

  • [Presentation] Duchenne型筋ジストロフィーに対して変異ジストロフィンエキソンのスキッピング誘導活性を有する経口投与可能な新規CLK1阻害剤の開発2017
    • Author(s)
      佐古有季哉、二宮賢介、奥野友紀子、豊本雅靖、西田篤史、小池悠華、大江賢治、喜井勲、吉田優、橋本有弘、細谷孝充、松尾雅文、萩原正敏
    • Organizer
      2017年度　生命科学系学会合同年次大会
    • Data Source
      KAKENHI-PROJECT-15H05721

  • [Presentation] 遺伝病を治す薬を創ろう!-学生時代からの夢の実現に向けて2017
    • Author(s)
      萩原正敏
    • Organizer
      平成29年度三医会定期総会
    • Place of Presentation
      三重
    • Year and Date
      2017-06-18
    • Data Source
      KAKENHI-PROJECT-21249013

  • [Presentation] 先天性神経疾患を標的とした創薬2017
    • Author(s)
      萩原正敏
    • Organizer
      第47回(2017)新潟神経学夏期セミナー
    • Place of Presentation
      新潟
    • Year and Date
      2017-07-29
    • Data Source
      KAKENHI-PROJECT-21249013

  • [Presentation] エピゲノム創薬で治療できる可能性のある神経疾患などの難病について2017
    • Author(s)
      萩原正敏
    • Organizer
      第44回日本毒性学会学術年会
    • Invited
    • Data Source
      KAKENHI-PROJECT-15H05721

  • [Presentation] Entrepreneurship Award Lecture2017
    • Author(s)
      Masatoshi Hagiwara
    • Organizer
      FAOBMB2017
    • Place of Presentation
      KOBE
    • Year and Date
      2017-12-07
    • Data Source
      KAKENHI-PROJECT-21249013

  • [Presentation] エピゲノム創薬で治療できる可能性のある神経疾患などの難病について2017
    • Author(s)
      萩原正敏
    • Organizer
      第44回日本毒性学会学術年会
    • Place of Presentation
      横浜
    • Year and Date
      2017-07-11
    • Data Source
      KAKENHI-PROJECT-21249013

  • [Presentation] Development of an orally available inhibitor of CLK1 for skipping a mutated dystrophin exon in Duchenne muscular dystrophy.2017
    • Author(s)
      佐古有季哉、二宮賢介、奥野友紀子、豊本雅靖、西田篤史、小池悠華、大江賢治、喜井 勲、吉田 優、橋本 有弘、細谷孝充、松尾雅文、萩原正敏
    • Organizer
      International Chemical Biology Society 2017
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H05721

  • [Presentation] スプライシング操作化合物TG003の標的エキソン探索アルゴリズムの開発、および改良2017
    • Author(s)
      飯田 慶、豊島 裕美、佐久間 真紀、出縄 政嗣、萩原 正敏
    • Organizer
      2017年度　生命科学系学会合同年次大会
    • Data Source
      KAKENHI-PROJECT-15H05721

  • [Presentation] スプライシング操作薬による遺伝病治療2017
    • Author(s)
      萩原正敏
    • Organizer
      2017年度　生命科学系学会合同年次大会
    • Invited
    • Data Source
      KAKENHI-PROJECT-15H05721

  • [Presentation] 京都大学におけるアカデミア創薬の取り組みの紹介2017
    • Author(s)
      萩原正敏
    • Organizer
      The 1^<st> KYOTO-SPARK Symposium Construction of a Drug Discovery Ecosystem between Academia-Pharma
    • Place of Presentation
      京都
    • Year and Date
      2017-02-15
    • Data Source
      KAKENHI-PROJECT-21249013

  • [Presentation] Chemical therapeutics of congenital diseases by manipulating transcriptome.2017
    • Author(s)
      Masatoshi Hagiwara
    • Organizer
      Cutting Edge Developments in RNA Biology for the Control of Gene Expression.
    • Place of Presentation
      Okinawa-Japan
    • Year and Date
      2017-11-13
    • Data Source
      KAKENHI-PROJECT-21249013

  • [Presentation] 種間比較解析に基づく、スプライシング操作化合物標的エキソン探索アルゴリズムの改良2017
    • Author(s)
      飯田慶、豊島裕美、佐久間真紀、出繩政嗣、萩原正敏
    • Organizer
      第19回日本RNA学会　年会
    • Data Source
      KAKENHI-PROJECT-15H05721

  • [Presentation] スプライシング操作薬による遺伝病治療2017
    • Author(s)
      萩原正敏
    • Organizer
      2017年度生命科学系学会合同年次大会Con Bio2017
    • Place of Presentation
      兵庫
    • Year and Date
      2017-12-09
    • Data Source
      KAKENHI-PROJECT-21249013

  • [Presentation] 基礎研究から医師主導治験に至るワンストップ創薬2017
    • Author(s)
      萩原正敏
    • Organizer
      第90回日本薬理学会年会
    • Place of Presentation
      長崎
    • Year and Date
      2017-03-15
    • Data Source
      KAKENHI-PROJECT-21249013

  • [Presentation] アカデミア創薬のワンストップ拠点構想2017
    • Author(s)
      萩原正敏
    • Organizer
      京都大学医薬系総合研究棟「イノベーションハブ京都」開所式典
    • Place of Presentation
      京都
    • Year and Date
      2017-09-13
    • Data Source
      KAKENHI-PROJECT-21249013

  • [Presentation] Academia drug discovery with novel strategies of chemical biology2017
    • Author(s)
      Masatoshi Hagiwara
    • Organizer
      International Chemical Biology Society 2017
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H05721

  • [Presentation] 分化状態の異なる筋肉細胞におけるスプライシング操作化合物TG003の効果の違い2016
    • Author(s)
      飯田慶、佐久間真紀、豊島裕美、出縄政嗣、萩原正敏
    • Organizer
      第39回日本分子生物学会年会
    • Data Source
      KAKENHI-PROJECT-15H05721

  • [Presentation] Duchenne型筋ジストロフィーに対するエキソンスキッピング治療薬候補化合物である新規CLK1特異的阻害剤2016
    • Author(s)
      佐古有季哉、二宮賢介、奥野友紀子、豊本雅靖、西田篤史、小池悠華、大江賢治、喜井勲、吉田優、細谷孝充、松尾雅文、萩原正敏
    • Organizer
      日本ケミカルバイオロジー学会　第11回年会
    • Data Source
      KAKENHI-PROJECT-15H05721

  • [Presentation] エクソンスキップ誘導薬とエクソン含有誘導薬による遺伝性難病の治療2016
    • Author(s)
      萩原正敏
    • Organizer
      第89回日本生化学会大会
    • Place of Presentation
      宮城
    • Year and Date
      2016-09-25
    • Data Source
      KAKENHI-PROJECT-21249013

  • [Presentation] Computational characterization of targeting rules of splicing-modulating small molecule: TG003 in differentiated and undifferentiated muscle cells.2016
    • Author(s)
      Kei IIDA, Maki Sakuma, Hiromi Toyoshima, Masatsugu Denawa, and Masatoshi Hagiwara
    • Organizer
      RNA meeting 2016
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H05721

  • [Presentation] 京都大学発アカデミア創薬-卓越した基礎研究から医師主導治験まで-2016
    • Author(s)
      萩原正敏
    • Organizer
      第8回関西ライフサイエンス・リーディングサイエンティストセミナー
    • Place of Presentation
      大阪
    • Year and Date
      2016-06-10
    • Data Source
      KAKENHI-PROJECT-21249013

  • [Presentation] Drug Discovery in Academia -from the drug screening to the clinical trial-2016
    • Author(s)
      萩原正敏
    • Organizer
      日本ケミカルバイオロジー学会第11回年会(日豪合同ケミカルバイオロジーシンポジウム)
    • Place of Presentation
      京都
    • Year and Date
      2016-06-16
    • Data Source
      KAKENHI-PROJECT-21249013

  • [Presentation] Diseasome情報を活用したPhenomics創薬へ2016
    • Author(s)
      萩原正敏
    • Organizer
      第105回病理学会総会
    • Place of Presentation
      宮城
    • Year and Date
      2016-05-13
    • Data Source
      KAKENHI-PROJECT-21249013

  • [Presentation] RNAスプライシングを操作すれば遺伝情報の異常を是正できるか?2016
    • Author(s)
      萩原正敏
    • Organizer
      生理化学ユニットシンポジウム
    • Place of Presentation
      京都
    • Year and Date
      2016-12-22
    • Data Source
      KAKENHI-PROJECT-21249013

  • [Presentation] 低分子化合物による再生医療の現実2016
    • Author(s)
      萩原正敏
    • Organizer
      第39回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2016-12-01
    • Data Source
      KAKENHI-PROJECT-21249013

  • [Presentation] New chemical therapeutics of genetic diseases by manipulating transcriptome2016
    • Author(s)
      萩原正敏
    • Organizer
      Tokyo Medical & Dental University 15^<th> Surugadai International Symposium & Joint Usage/Research Program of medical research Institute International Symposium
    • Place of Presentation
      東京
    • Year and Date
      2016-11-29
    • Data Source
      KAKENHI-PROJECT-21249013

  • [Presentation] アカデミアにおける創薬医学の展開：化合物スクリーニングから医師主導治験まで2016
    • Author(s)
      萩原　正敏
    • Organizer
      日本薬理学会
    • Place of Presentation
      パシフィコ横浜会議センター（神奈川県横浜市）
    • Year and Date
      2016-03-10
    • Data Source
      KAKENHI-PROJECT-15H05721

  • [Presentation] トランスクリプトーム創薬の実現に向けて2016
    • Author(s)
      萩原正敏
    • Organizer
      第43回日本毒性学会学術年会
    • Place of Presentation
      愛知
    • Year and Date
      2016-07-01
    • Data Source
      KAKENHI-PROJECT-21249013

  • [Presentation] 化合物スクリーニングから臨床試験まで : ワンストップ創薬拠点2015
    • Author(s)
      萩原正敏
    • Organizer
      PDIS最先端セミナー 創薬につなぐ日本の創薬基盤技術 構造生物学とゲノム科学の最前線はここまで来た
    • Place of Presentation
      東京
    • Year and Date
      2015-02-04
    • Data Source
      KAKENHI-PROJECT-21249013

  • [Presentation] 哺乳類の超長鎖遺伝子発現に必要である、RNA結合タンパク質によるmRNAプロセッシングと転写伸長活性化機構2015
    • Author(s)
      武内章英、飯田慶、二宮賢介、出縄政嗣、坪田智明、伊藤美佳子、大野欽司、萩原正敏
    • Organizer
      第17回日本RNA学会年会　口頭発表
    • Place of Presentation
      ホテルライフォート札幌
    • Year and Date
      2015-07-15
    • Data Source
      KAKENHI-PROJECT-15H02505

  • [Presentation] RBM24 IS RESPONSIBLE FOR TISSUE-SPECIFIC ABERRANT SPLICING IN FAMILIAL DYSAUTONOMIA2015
    • Author(s)
      Kenji Ohe, Mayumi Yoshida, Kensuke Ninomiya, Maki Sakuma, Tomomi Usui, Takayuki Nojima, Naoyuki Kataoka, Masatoshi Hagiwara
    • Organizer
      CSHL Eukaryotic mRNA Processing, 2015 Oral presentation
    • Place of Presentation
      Cold Spring Harbor Laboratory, NY
    • Year and Date
      2015-08-18
    • Data Source
      KAKENHI-PROJECT-15H02505

  • [Presentation] 京都大学におけるワンストップ創薬の試み-卓越した基礎研究から迅速な臨床試験まで-2015
    • Author(s)
      萩原正敏
    • Organizer
      エーザイ株式会社社内研究者向け講演会
    • Place of Presentation
      茨城
    • Year and Date
      2015-10-27
    • Data Source
      KAKENHI-PROJECT-21249013

  • [Presentation] 大学発-セレディピティーの最大化に向けて2015
    • Author(s)
      萩原正敏
    • Organizer
      薬学会第135年会シンポジウム「動き出した創薬オープンイノベーションネットワーク」
    • Place of Presentation
      兵庫
    • Year and Date
      2015-03-26
    • Data Source
      KAKENHI-PROJECT-21249013

  • [Presentation] 卓越した基礎研究から迅速な臨床試験まで：京都大学におけるワンストップ創薬の試み2015
    • Author(s)
      萩原正敏
    • Organizer
      第88回日本薬理学会
    • Place of Presentation
      愛知
    • Year and Date
      2015-03-19
    • Invited
    • Data Source
      KAKENHI-PROJECT-24241076

  • [Presentation] 骨格筋における超長鎖遺伝子発現制御の分子機構の解明2015
    • Author(s)
      細川元靖、武内章英、谷端淳、武田伸一、萩原正敏
    • Organizer
      第17回日本RNA学会年会　ポスター発表
    • Place of Presentation
      ホテルライフォート札幌
    • Year and Date
      2015-07-15
    • Data Source
      KAKENHI-PROJECT-15H02505

  • [Presentation] 幸運の女神に後髪なし～難病に対する治療薬開発について～2015
    • Author(s)
      萩原正敏
    • Organizer
      学校法人暁中学・高等学校 「第3回キャリア教育講演会」
    • Place of Presentation
      三重
    • Year and Date
      2015-06-17
    • Data Source
      KAKENHI-PROJECT-21249013

  • [Presentation] セレンディピティーを最大化するアカデミア創薬の試み2015
    • Author(s)
      萩原正敏
    • Organizer
      京都大学臨床研究総合センター研究セミナー
    • Place of Presentation
      京都
    • Year and Date
      2015-06-17
    • Data Source
      KAKENHI-PROJECT-21249013

  • [Presentation] 情熱大陸2015
    • Author(s)
      萩原正敏
    • Organizer
      三重県立桑名高等学校パネルディスカッション
    • Place of Presentation
      三重
    • Year and Date
      2015-03-18
    • Data Source
      KAKENHI-PROJECT-21249013

  • [Presentation] 先天性難治疾患のスプライシング治療2015
    • Author(s)
      萩原正敏
    • Organizer
      第38回日本分子生物学会年会、第88回日本生化学会大会合同大会
    • Place of Presentation
      神戸
    • Year and Date
      2015-12-01
    • Data Source
      KAKENHI-PROJECT-21249013

  • [Presentation] アカデミアにおけるトランスクリプトーム創薬の試み2015
    • Author(s)
      萩原正敏
    • Organizer
      科研製薬株式会社における講演会
    • Place of Presentation
      京都
    • Year and Date
      2015-07-29
    • Data Source
      KAKENHI-PROJECT-21249013

  • [Presentation] トランスクリプトーム創薬による難病の革新的治療薬開発2015
    • Author(s)
      萩原正敏
    • Organizer
      第29回日本医学会総会2015
    • Place of Presentation
      京都
    • Year and Date
      2015-04-11
    • Data Source
      KAKENHI-PROJECT-21249013

  • [Presentation] 化合物スクリーニングから臨床試験まで：ワンストップ創薬拠点2015
    • Author(s)
      萩原正敏
    • Organizer
      PDIS最先端セミナー　創薬につなぐ日本の創薬基盤技術　構造生物学とゲノム科学の最前線はここまで来た
    • Place of Presentation
      東京
    • Year and Date
      2015-02-04
    • Invited
    • Data Source
      KAKENHI-PROJECT-24241076

  • [Presentation] New chemical therapeutics of genetic diseases by manipulating transcriptome.2015
    • Author(s)
      Masatoshi Hagiwara
    • Organizer
      Top Global University Japan, 1^<st> Joint Symposium of International Partners.
    • Place of Presentation
      Kyoto JAPAN.
    • Year and Date
      2015-10-02
    • Data Source
      KAKENHI-PROJECT-21249013

  • [Presentation] 卓越した基礎研究から迅速な臨床試験まで : 京都大学におけるワンストップ創薬の試み2015
    • Author(s)
      萩原正敏
    • Organizer
      第88回日本薬理学会 シンポジウム19「ケミカルバイオロジーによる難病治療薬開発の最前線」
    • Place of Presentation
      愛知
    • Year and Date
      2015-03-19
    • Data Source
      KAKENHI-PROJECT-21249013

  • [Presentation] 不治の難病に挑むトランスクリプトーム創薬2015
    • Author(s)
      萩原正敏
    • Organizer
      第42回日本毒性学会学術年会
    • Place of Presentation
      石川
    • Year and Date
      2015-07-01
    • Data Source
      KAKENHI-PROJECT-21249013

  • [Presentation] 大学発-セレディピティーの最大化に向けて2015
    • Author(s)
      萩原正敏
    • Organizer
      薬学会第135年会
    • Place of Presentation
      兵庫
    • Year and Date
      2015-03-26
    • Invited
    • Data Source
      KAKENHI-PROJECT-24241076

  • [Presentation] 変異ジストロフィン遺伝子に対するエクソンスキップ誘導活性を有する化合物の探索2015
    • Author(s)
      佐古有季哉、二宮賢介、喜井勲、細谷孝充、萩原正敏
    • Organizer
      第17回日本RNA学会年会　ポスター発表
    • Place of Presentation
      ホテルライフォート札幌
    • Year and Date
      2015-07-15
    • Data Source
      KAKENHI-PROJECT-15H02505

  • [Presentation] 先天性難治疾患のスプライシング治療2015
    • Author(s)
      萩原　正敏
    • Organizer
      第38回日本分子生物学会年会
    • Place of Presentation
      神戸国際展示場（兵庫県神戸市）
    • Year and Date
      2015-12-01
    • Data Source
      KAKENHI-PROJECT-15H05721

  • [Presentation] 卓越した基礎研究から迅速な臨床試験まで : 京都大学におけるワンストップ創薬の試み2015
    • Author(s)
      萩原正敏
    • Organizer
      藤田保健衛生大学研究最前線セミナー
    • Place of Presentation
      愛知
    • Year and Date
      2015-10-01
    • Data Source
      KAKENHI-PROJECT-21249013

  • [Presentation] 今日は治せぬ病を、明日に治す医師を育てる2015
    • Author(s)
      萩原正敏
    • Organizer
      京都大学医学部校友会第8回総会・講演会
    • Place of Presentation
      京都
    • Year and Date
      2015-09-26
    • Data Source
      KAKENHI-PROJECT-21249013

  • [Presentation] トランスクリプトーム創薬による難病治療の試み2015
    • Author(s)
      萩原正敏
    • Organizer
      文部科学省科学研究費補助金「新学術領域研究(研究領域提案型)」第8回公開シンポジウム
    • Place of Presentation
      宮城
    • Year and Date
      2015-06-08
    • Data Source
      KAKENHI-PROJECT-21249013

  • [Presentation] Challenges to cure congenital diseases with RNA-targeting chemical compounds2015
    • Author(s)
      萩原正敏
    • Organizer
      Molecular Clock 2015 Epigenetic Landscape in Biological Rhythms
    • Place of Presentation
      京都
    • Year and Date
      2015-03-27
    • Data Source
      KAKENHI-PROJECT-21249013

  • [Presentation] 新規核内intron-retaining RNA の探索と解析2015
    • Author(s)
      二宮賢介、飯田慶、佐久間真紀、佐古有季哉、萩原正敏
    • Organizer
      第17回日本RNA学会年会　ポスター発表
    • Place of Presentation
      ホテルライフォート札幌
    • Year and Date
      2015-07-15
    • Data Source
      KAKENHI-PROJECT-15H02505

  • [Presentation] 卓越した基礎研究から迅速な臨床試験まで : 京都大学におけるワンストップ創薬の試み2015
    • Author(s)
      萩原正敏
    • Organizer
      京大医学部・萩原先生の講演会(第一三共株式会社)
    • Place of Presentation
      東京
    • Year and Date
      2015-02-19
    • Data Source
      KAKENHI-PROJECT-21249013

  • [Presentation] 家族性自律神経失調症におけるIKBKAP遺伝子の組織特異的異常スプライシングの責任分子の同定2015
    • Author(s)
      大江賢治、吉田真弓、二宮賢介、佐久間真紀、薄井知美、野島孝之、萩原正敏、片岡直行
    • Organizer
      第17回日本RNA学会年会　口頭発表
    • Place of Presentation
      ホテルライフォート札幌
    • Year and Date
      2015-07-15
    • Data Source
      KAKENHI-PROJECT-15H02505

  • [Presentation] 遺伝病に挑むトランスクリプトーム創薬2015
    • Author(s)
      萩原正敏
    • Organizer
      第三回Academy of Aging and Cardiovascular-Diabetes Research
    • Place of Presentation
      東京
    • Year and Date
      2015-01-10
    • Data Source
      KAKENHI-PROJECT-21249013

  • [Presentation] 遺伝病治療を可能にするトランスクリプトーム創薬2014
    • Author(s)
      萩原正敏
    • Organizer
      第41回日本毒性学会学術年会
    • Place of Presentation
      兵庫
    • Year and Date
      2014-07-02
    • Data Source
      KAKENHI-PROJECT-21249013

  • [Presentation] 医学研究支援の取り組み : 持続的な研究環境・資源の維持に向けて2014
    • Author(s)
      萩原正敏
    • Organizer
      第1回バイオ・フロンティア・プラットフォームシンポジウム「京滋地域アカデミア連関における研究支援体制の整備」
    • Place of Presentation
      京都
    • Year and Date
      2014-12-01
    • Data Source
      KAKENHI-PROJECT-21249013

  • [Presentation] 先天性難治疾患の治療を可能にするトランスクリプトーム創薬戦略 Challenge to hereditary diseases with transcriptom the rapy2014
    • Author(s)
      萩原正敏
    • Organizer
      RCGMフロンティア国際シンポジウム
    • Place of Presentation
      埼玉
    • Year and Date
      2014-11-01
    • Data Source
      KAKENHI-PROJECT-21249013

  • [Presentation] 家族性自立神経失調症を標的とするトランスクリプトーム創薬2014
    • Author(s)
      萩原正敏
    • Organizer
      千里ライフサイエンス新適塾『脳はおもしろい』第4回会合
    • Place of Presentation
      大阪
    • Year and Date
      2014-04-11
    • Data Source
      KAKENHI-PROJECT-21249013

  • [Presentation] 遺伝病治療を目指すトランスクリプトーム創薬2014
    • Author(s)
      萩原正敏
    • Organizer
      第16回「JBICバイオ関連基盤技術研究会」
    • Place of Presentation
      東京
    • Year and Date
      2014-04-15
    • Invited
    • Data Source
      KAKENHI-PROJECT-24241076

  • [Presentation] 京大医学研究科におけるティッシュリソースセンター構想2014
    • Author(s)
      萩原正敏
    • Organizer
      京大病院キャンサーバイオバンクシンポジウム
    • Place of Presentation
      京都
    • Year and Date
      2014-02-03
    • Data Source
      KAKENHI-PROJECT-21249013

  • [Presentation] RNAを標的とする創薬によって、今は治らぬ病を明日には治す!2014
    • Author(s)
      萩原正敏
    • Organizer
      第47回京都ききょう会生涯研修会
    • Place of Presentation
      京都
    • Year and Date
      2014-03-21
    • Data Source
      KAKENHI-PROJECT-21249013

  • [Presentation] RNAを標的とする創薬によって難治疾患へ挑む2014
    • Author(s)
      萩原正敏
    • Organizer
      第37回日本神経科学大会
    • Place of Presentation
      神奈川
    • Year and Date
      2014-09-11
    • Data Source
      KAKENHI-PROJECT-21249013

  • [Presentation] Challenges to cure genetic disorders with RNA-targeting chemical compounds.2014
    • Author(s)
      Masatoshi Hagiwara
    • Organizer
      Seminar at ICREA and Center for Genomic Regulation (CRG)
    • Place of Presentation
      Barcelona, Spain
    • Year and Date
      2014-05-02
    • Data Source
      KAKENHI-PROJECT-21249013

  • [Presentation] Drug Discovery and Development in Academia-How to Maximize the Serentivity?-2014
    • Author(s)
      萩原正敏
    • Organizer
      Cutting edge information exchange meeting
    • Place of Presentation
      京都
    • Year and Date
      2014-10-09
    • Data Source
      KAKENHI-PROJECT-21249013

  • [Presentation] Challenge to Cure Hereditary Diseases with "RNA-targeting" Chemical Compounds2014
    • Author(s)
      萩原正敏
    • Organizer
      International Conference on Chemical Biology 2014
    • Place of Presentation
      インド
    • Invited
    • Data Source
      KAKENHI-PROJECT-24241076

  • [Presentation] Prospective novel therapeutics for tauopathies2014
    • Author(s)
      Masatoshi Hagiwara
    • Organizer
      Asia Aging Core for Longevity(AACL)
    • Place of Presentation
      Jeju
    • Year and Date
      2014-09-24
    • Data Source
      KAKENHI-PROJECT-21249013

  • [Presentation] Challenges to cure genetic diseases with RNA-targeting chemical compounds.2014
    • Author(s)
      Masatoshi Hagiwara
    • Organizer
      Seminar at Emory University school of Medicine Department of Pharmacology
    • Place of Presentation
      Atlanta, USA
    • Year and Date
      2014-11-21
    • Data Source
      KAKENHI-PROJECT-21249013

  • [Presentation] ゲノム創薬からセレンティビティ創薬への回帰2014
    • Author(s)
      萩原正敏
    • Organizer
      第2回遊人会関西支部会
    • Place of Presentation
      京都
    • Year and Date
      2014-11-28
    • Data Source
      KAKENHI-PROJECT-21249013

  • [Presentation] 今日は治せぬ病を、明日は治せる医師を、京大は育てる2014
    • Author(s)
      萩原正敏
    • Organizer
      立伊勢高等学校「第3回科学の甲子園全国優勝/サイエンス・オリンピアド参加報告会」
    • Place of Presentation
      三重
    • Year and Date
      2014-06-22
    • Data Source
      KAKENHI-PROJECT-21249013

  • [Presentation] リン酸化酵素とシャペロンの結合を指標とした阻害剤評価系の構築2014
    • Author(s)
      祖納元りえ、喜井勲、小池悠華、萩原正敏
    • Organizer
      第37回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2014-11-27
    • Data Source
      KAKENHI-PROJECT-24241076

  • [Presentation] 先天性疾患の治療に挑むトランスクリプトーム創薬2014
    • Author(s)
      萩原正敏
    • Organizer
      日本プロテオーム学会2014年会
    • Place of Presentation
      茨城
    • Year and Date
      2014-07-18
    • Data Source
      KAKENHI-PROJECT-21249013

  • [Presentation] Drug Discovery and Development in Academia-How to Maximize the Serentivity?-2014
    • Author(s)
      萩原正敏
    • Organizer
      Cutting edge information exchange meeting
    • Place of Presentation
      京都
    • Year and Date
      2014-10-09
    • Invited
    • Data Source
      KAKENHI-PROJECT-24241076

  • [Presentation] Challenges to cure hereditary diseases with “RNA targeting” chemical compounds.2014
    • Author(s)
      Masatoshi Hagiwara
    • Organizer
      Bordeaux-Kyoto Symposium, Université de Bordeaux
    • Place of Presentation
      Bordeaux, France
    • Year and Date
      2014-05-05
    • Data Source
      KAKENHI-PROJECT-21249013

  • [Presentation] トランスクリプトーム創薬による遺伝病の克服2014
    • Author(s)
      萩原正敏
    • Organizer
      第4回前立腺生物学シンポジウム 伊勢志摩2014
    • Place of Presentation
      三重
    • Year and Date
      2014-06-27
    • Data Source
      KAKENHI-PROJECT-21249013

  • [Presentation] 網羅的スプライシング暗号解析に基づくRNA病の解明と治療技術の探索2014
    • Author(s)
      萩原正敏
    • Organizer
      平成25年度セルイノベーション公開シンポジウム 次世代シーケンス解析技術の超微量化と創薬・医療分野への応用に向けて
    • Place of Presentation
      東京
    • Year and Date
      2014-01-28
    • Data Source
      KAKENHI-PROJECT-21249013

  • [Presentation] Drug Discovery and Development in Academia-How to Maximize the Serentivity2014
    • Author(s)
      萩原正敏
    • Organizer
      NIHS SPECIAL LECTURE
    • Place of Presentation
      東京
    • Year and Date
      2014-10-29
    • Data Source
      KAKENHI-PROJECT-21249013

  • [Presentation] 難治性疾患に対する創薬2014
    • Author(s)
      萩原正敏
    • Organizer
      杏林製薬株式会社創薬研究所における講演会
    • Place of Presentation
      栃木
    • Year and Date
      2014-12-24
    • Data Source
      KAKENHI-PROJECT-21249013

  • [Presentation] 遺伝病治療を目指すトランスクリプトーム創薬2014
    • Author(s)
      萩原正敏
    • Organizer
      第16回「JBICバイオ関連基盤技術研究会」
    • Place of Presentation
      東京
    • Year and Date
      2014-04-15
    • Data Source
      KAKENHI-PROJECT-21249013

  • [Presentation] Challenges to cure genetic diseases with RNA-targeting chemical compounds.2014
    • Author(s)
      Masatoshi Hagiwara
    • Organizer
      Seminar at Sanford-Burnham Medical Research Institute
    • Place of Presentation
      San Diego USA
    • Year and Date
      2014-04-27
    • Data Source
      KAKENHI-PROJECT-21249013

  • [Presentation] Challenges to congenital genetic disorders with “RNA-targeting” chemical compounds.2014
    • Author(s)
      Masatoshi Hagiwara
    • Organizer
      Seminar at washington University School of Medicine
    • Place of Presentation
      St. Louis USA
    • Year and Date
      2014-04-29
    • Data Source
      KAKENHI-PROJECT-21249013

  • [Presentation] Challenge to Cure Hereditary Diseases with “RNA-targeting” Chemical Compounds2014
    • Author(s)
      Masatoshi Hagiwara
    • Organizer
      International Conference on Chemical Biology 2014
    • Place of Presentation
      インド
    • Year and Date
      2014-02-07
    • Data Source
      KAKENHI-PROJECT-21249013

  • [Presentation] 難治疾患の治療を可能にするトランスクリプトーム創薬戦略2014
    • Author(s)
      萩原正敏
    • Organizer
      The Graduate Course “Lifestyle-related diseases, Aging and Metabolism” Course Retreat 2013
    • Place of Presentation
      京都
    • Year and Date
      2014-01-19
    • Data Source
      KAKENHI-PROJECT-21249013

  • [Presentation] RNA結合タンパクと難治の神経・筋疾患2014
    • Author(s)
      萩原正敏
    • Organizer
      転写終結タンパク質のセミナー
    • Place of Presentation
      東京
    • Year and Date
      2014-01-27
    • Data Source
      KAKENHI-PROJECT-21249013

  • [Presentation] Challenges to cure genetic diseases with RNA-targeting chemical compounds2014
    • Author(s)
      Masatoshi Hagiwara
    • Organizer
      京都大学・台湾大学共催シンポジウム
    • Place of Presentation
      京都
    • Year and Date
      2014-09-02
    • Data Source
      KAKENHI-PROJECT-21249013

  • [Presentation] プロテオームの多様性創出のメカニズムについて2013
    • Author(s)
      萩原正敏
    • Organizer
      JHUPO サテライトシンポジウム
    • Place of Presentation
      京都
    • Year and Date
      2013-01-18
    • Data Source
      KAKENHI-PROJECT-21249013

  • [Presentation] 明日の医療を育む2013
    • Author(s)
      萩原正敏
    • Organizer
      白菊会総会
    • Place of Presentation
      京都
    • Year and Date
      2013-10-18
    • Data Source
      KAKENHI-PROJECT-21249013

  • [Presentation] RNAを標的とする創薬によって難治疾患へ挑む2013
    • Author(s)
      萩原正敏
    • Organizer
      大阪大学セミナー
    • Place of Presentation
      大阪
    • Year and Date
      2013-07-04
    • Data Source
      KAKENHI-PROJECT-21249013

  • [Presentation] RNAを標的とする創薬で難病に挑む2013
    • Author(s)
      萩原正敏
    • Organizer
      未来の研究プロジェクトWinter Seminar 2013
    • Place of Presentation
      京都
    • Year and Date
      2013-02-16
    • Data Source
      KAKENHI-PROJECT-21249013

  • [Presentation] 核内タンパク・RNA複合体の構造と機能2013
    • Author(s)
      萩原正敏
    • Organizer
      第86回日本生化学会大会
    • Place of Presentation
      横浜
    • Year and Date
      2013-09-11
    • Data Source
      KAKENHI-PROJECT-21249013

  • [Presentation] Visualization and manipulation of pre-mRNA processing2013
    • Author(s)
      Masatoshi Hagiwara
    • Organizer
      「時空間情報イメージング研究教育推進拠点」キックオフシンポジウム
    • Place of Presentation
      京都
    • Year and Date
      2013-05-23
    • Data Source
      KAKENHI-PROJECT-21249013

  • [Presentation] 医薬連携によるワンストップ創薬2013
    • Author(s)
      萩原正敏
    • Organizer
      日本薬理学会アカデミア創薬シーズ探索シンポジウム
    • Place of Presentation
      博多
    • Invited
    • Data Source
      KAKENHI-PROJECT-24241076

  • [Presentation] 広汎性発達障害に対するエピゲノム創薬2013
    • Author(s)
      萩原正敏
    • Organizer
      第23回日本臨床精神神経薬理学会・第43回日本神経精神薬理学会合同年会シンポジウム「エピジェネティクスと精神薬理との接点」
    • Place of Presentation
      沖縄
    • Year and Date
      2013-10-25
    • Data Source
      KAKENHI-PROJECT-21249013

  • [Presentation] 先天性難治疾患に対する創薬の試み：TRNDK2013
    • Author(s)
      萩原正敏
    • Organizer
      第1回創薬等支援技術基盤プラットフォーム公開シンポジウム
    • Place of Presentation
      第1回創薬等支援技術基盤プラットフォーム公開シンポジウム
    • Invited
    • Data Source
      KAKENHI-PROJECT-24241076

  • [Presentation] mRNAを標的とした新しい創薬研究の展開2013
    • Author(s)
      萩原正敏
    • Organizer
      長野哲雄教授定年退職記念シンポジウム「ケミカルバイオロジーの大展開」
    • Place of Presentation
      東京
    • Invited
    • Data Source
      KAKENHI-PROJECT-24241076

  • [Presentation] 京都大学におけるセレンディピティ創薬の試み2013
    • Author(s)
      萩原正敏
    • Organizer
      公開シンポジウム「オールジャパンでの創薬支援体制の構築に向けて」
    • Place of Presentation
      大阪
    • Year and Date
      2013-05-17
    • Data Source
      KAKENHI-PROJECT-21249013

  • [Presentation] RNAを標的とする創薬によって難治疾患へ挑む2013
    • Author(s)
      萩原正敏
    • Organizer
      臨床中核拠点シンポジウム
    • Place of Presentation
      京都
    • Year and Date
      2013-02-09
    • Data Source
      KAKENHI-PROJECT-21249013

  • [Presentation] トランスクリプトーム創薬による遺伝病への挑戦2013
    • Author(s)
      萩原正敏
    • Organizer
      奈良県立医科大学第二回基礎教育協議会講演会
    • Place of Presentation
      奈良
    • Year and Date
      2013-06-28
    • Data Source
      KAKENHI-PROJECT-21249013

  • [Presentation] 先天性難治疾患に対する創薬の試み : TRNDK2013
    • Author(s)
      萩原正敏
    • Organizer
      第1回創薬等支援技術基盤プラットフォーム公開シンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2013-09-24
    • Data Source
      KAKENHI-PROJECT-21249013

  • [Presentation] 京都大学におけるセレンディピティ創薬の試み2013
    • Author(s)
      萩原正敏
    • Organizer
      オールジャパンでの創薬支援体制の構築に向けて
    • Place of Presentation
      大阪
    • Invited
    • Data Source
      KAKENHI-PROJECT-24241076

  • [Presentation] RNAプロセシング異常と神経疾患2013
    • Author(s)
      萩原正敏
    • Organizer
      京都府立医科大学医学研究科講義
    • Place of Presentation
      京都
    • Year and Date
      2013-10-01
    • Data Source
      KAKENHI-PROJECT-21249013

  • [Presentation] RNAを標的とする創薬で難病に挑む2013
    • Author(s)
      萩原正敏
    • Organizer
      三重大学医学研究科特別講義
    • Place of Presentation
      三重
    • Year and Date
      2013-02-01
    • Data Source
      KAKENHI-PROJECT-21249013

  • [Presentation] mRNAを標的とした新しい創薬研究の展開2013
    • Author(s)
      萩原正敏
    • Organizer
      長野哲雄教授定年退職記念シンポジウム「ケミカルバイオロジーの大展開」
    • Place of Presentation
      東京
    • Year and Date
      2013-03-16
    • Data Source
      KAKENHI-PROJECT-21249013

  • [Presentation] 京都大学医学部の歴史と医学教育2013
    • Author(s)
      萩原正敏
    • Organizer
      第14回近畿献体懇話会
    • Place of Presentation
      京都
    • Year and Date
      2013-07-24
    • Data Source
      KAKENHI-PROJECT-21249013

  • [Presentation] Challenges to congenital genetic disorder with “RNA-targeting” chemical compounds2013
    • Author(s)
      Masatoshi Hagiwara
    • Organizer
      SLAS2013 2nd Annual Conference & Exhibition
    • Place of Presentation
      ORLAND,FL,USA
    • Invited
    • Data Source
      KAKENHI-PROJECT-24241076

  • [Presentation] 先天性難治疾患の治療を可能にするトランスクリプトーム創薬戦略2013
    • Author(s)
      萩原正敏
    • Organizer
      第2回創薬・医療技術基盤プログラムワークショップ「理研発創薬の現状と将来」
    • Place of Presentation
      埼玉
    • Year and Date
      2013-11-29
    • Data Source
      KAKENHI-PROJECT-21249013

  • [Presentation] 医薬連携によるワンストップ創薬2013
    • Author(s)
      萩原正敏
    • Organizer
      日本薬理学会アカデミア創薬シーズ探索シンポジウム
    • Place of Presentation
      博多
    • Year and Date
      2013-03-22
    • Data Source
      KAKENHI-PROJECT-21249013

  • [Presentation] Development of DYRK1A inhibitors for novel therapeutics of Alzheimer's disease.2013
    • Author(s)
      Masatoshi Hagiwara
    • Organizer
      6^<th> Asian Aging Core for Longevity (AACL) conference in Kyoto (Aging Research Forum between Japan and Korea)
    • Place of Presentation
      京都
    • Year and Date
      2013-11-02
    • Data Source
      KAKENHI-PROJECT-21249013

  • [Presentation] RNAを標的とする創薬によって難治疾患へ挑む ; ダウン症からアルツハイマー病治療薬へ2013
    • Author(s)
      萩原正敏
    • Organizer
      いなべ市医師会学術講演会
    • Place of Presentation
      三重(いなべ)
    • Year and Date
      2013-03-30
    • Data Source
      KAKENHI-PROJECT-21249013

  • [Presentation] 難治疾患の治療を可能にするトランスクリプトーム創薬戦略2013
    • Author(s)
      萩原正敏
    • Organizer
      第6回リサーチ・イノベーションミーティング
    • Place of Presentation
      神戸
    • Year and Date
      2013-08-31
    • Data Source
      KAKENHI-PROJECT-21249013

  • [Presentation] RNAを標的とする創薬によって難治疾患へ挑む2013
    • Author(s)
      萩原正敏
    • Organizer
      大阪大学セミナー
    • Place of Presentation
      大阪
    • Invited
    • Data Source
      KAKENHI-PROJECT-24241076

  • [Presentation] RNA を標的とする創薬によって難治疾患に挑む2012
    • Author(s)
      萩原正敏
    • Organizer
      第36回阿蘇シンポジウム
    • Place of Presentation
      熊本
    • Year and Date
      2012-08-03
    • Data Source
      KAKENHI-PROJECT-21249013

  • [Presentation] Chemical targeting of RNA processing for new therapeutics of congenital diseases2012
    • Author(s)
      Masatoshi Hagiwara
    • Organizer
      THE 1^<st> official of the INTERNATIONAL CHEMICALBIOLOGY SOCIETY
    • Place of Presentation
      Cambridge, USA.
    • Year and Date
      2012-10-04
    • Data Source
      KAKENHI-PROJECT-21249013

  • [Presentation] PUF60 is a Differentiation-Dependent Splicing Regulator Required for Myogenesis2012
    • Author(s)
      Kataoka N., Nojima,T., Oshiro-Ideue, T., Takeuchi, A., Kii, I. and Hagiwara, M
    • Organizer
      The 22nd CDB meeting "RNA Sciences in Cell and Developmental Biology II"Riken CDB
    • Place of Presentation
      Kobe Japan
    • Data Source
      KAKENHI-PROJECT-22603002

  • [Presentation] Challenges to congenital genetic disorder with"RNA-targeting" chemical compounds2012
    • Author(s)
      Masatoshi Hagiwara
    • Organizer
      SLAS2013 2^<nd> Annual Conference &Exhibition
    • Place of Presentation
      ORLAND,FL,USA.
    • Year and Date
      2012-01-14
    • Data Source
      KAKENHI-PROJECT-21249013

  • [Presentation] 家族性自律神経失調症原因遺伝子IKBKAPの異常スプライシング機構の解析2012
    • Author(s)
      片岡直行、吉田真弓、薄井知美、佐久間真紀、萩原正敏
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      福岡
    • Data Source
      KAKENHI-PROJECT-22603002

  • [Presentation] Chemical targeting of RNA processing for new therapeutics of congenital diseases2012
    • Author(s)
      Masatoshi Hagiwara
    • Organizer
      THE 1st official of the INTERNATIONAL CHEMICALBIOLOGY SOCIETY
    • Place of Presentation
      Cambridge,USA.
    • Invited
    • Data Source
      KAKENHI-PROJECT-21249013

  • [Presentation] スプライシング異常による疾患とその治療の可能性2012
    • Author(s)
      萩原正敏
    • Organizer
      オミックス医療研究会　創薬PG×分科会＆データベース分科会シンポジウム
    • Place of Presentation
      横浜
    • Invited
    • Data Source
      KAKENHI-PROJECT-24241076

  • [Presentation] Neural development and splicing code2012
    • Author(s)
      萩原正敏
    • Organizer
      第35回日本神経科学大会「RNA 結合タンパクと病態シンポジウム」
    • Place of Presentation
      名古屋
    • Year and Date
      2012-09-21
    • Data Source
      KAKENHI-PROJECT-21249013

  • [Presentation] Modulators for splicing of IKBKAP gene, a responsible gene for Familial dysautonomia2012
    • Author(s)
      Kataoka, N., Yoshida, M., Usui, T., Sakuma, M. and Hagiwara, M
    • Organizer
      Cold Spring Harbor Asia 2012 Conference on RNA Biology
    • Place of Presentation
      Suzhou, China
    • Data Source
      KAKENHI-PROJECT-22603002

  • [Presentation] New chemical screens for drugs of congenital genetic disorders targeting pre-mRNAs.2012
    • Author(s)
      萩原正敏
    • Organizer
      名古屋大学農学研究科大学院セミナー
    • Place of Presentation
      名古屋
    • Year and Date
      2012-09-24
    • Data Source
      KAKENHI-PROJECT-21249013

  • [Presentation] RNAを標的とする創薬によって難治疾患に挑む2012
    • Author(s)
      萩原正敏
    • Organizer
      第３６回阿蘇シンポジウム
    • Place of Presentation
      熊本
    • Invited
    • Data Source
      KAKENHI-PROJECT-24241076

  • [Presentation] Novel DYRK1A inhibitor applicable for Alzheimer disease2012
    • Author(s)
      Masatoshi Hagiwara
    • Organizer
      AACL-2012 Seoul Symposium
    • Place of Presentation
      Seoul
    • Year and Date
      2012-11-23
    • Data Source
      KAKENHI-PROJECT-21249013

  • [Presentation] New chemical screens for drugs of congenital genetic disorders targeting pre-mRNAs2012
    • Author(s)
      Masatoshi Hagiwara
    • Organizer
      Gordon Research Conference
    • Place of Presentation
      Newport, USA.
    • Year and Date
      2012-07-19
    • Data Source
      KAKENHI-PROJECT-21249013

  • [Presentation] スプライシング異常による疾患とその治療の可能性2012
    • Author(s)
      萩原正敏
    • Organizer
      オミックス医療研究会 創薬PG×分科会&データベース分科会シンポジウム
    • Place of Presentation
      横浜
    • Year and Date
      2012-12-26
    • Data Source
      KAKENHI-PROJECT-21249013

  • [Presentation] Novel DYRK1A inhibitor applicable for Alzheimer disease2012
    • Author(s)
      Masatoshi Hagiwara
    • Organizer
      AACL2012 Seoul Symposium
    • Place of Presentation
      Seoul
    • Invited
    • Data Source
      KAKENHI-PROJECT-24241076

  • [Presentation] Challenges to Congenital Genetic Disorders with "RNA-targeting" Chemical Compounds2012
    • Author(s)
      萩原　正敏
    • Organizer
      The 22nd CDB Meeting
    • Place of Presentation
      神戸
    • Invited
    • Data Source
      KAKENHI-PROJECT-24241076

  • [Presentation] RNAを操作して先天性の神経筋疾患を薬で治す2012
    • Author(s)
      萩原正敏
    • Organizer
      長崎大学医学研究科セミナー
    • Place of Presentation
      長崎
    • Year and Date
      2012-10-16
    • Data Source
      KAKENHI-PROJECT-21249013

  • [Presentation] Clk特異的阻害剤TG003を用いたジストロフィン遺伝子におけるエクソンスキッピング促進機構の解析2012
    • Author(s)
      片岡直行、西田篤史、飯田慶、松尾雅文、萩原正敏
    • Organizer
      第7回日本ケミカルバイオロジー学会
    • Place of Presentation
      京都
    • Data Source
      KAKENHI-PROJECT-22603002

  • [Presentation] RNA制御異常2012
    • Author(s)
      萩原正敏
    • Organizer
      京都大学大学院医学研究科教育コース、神経科学ミニコース「脳科学研究に資する分子ネットワーク解析の最前線」
    • Place of Presentation
      京都
    • Year and Date
      2012-07-13
    • Data Source
      KAKENHI-PROJECT-21249013

  • [Presentation] PUF60は筋分化特異的な選択的スプライシングの調節因子であり、筋発生に必要である2012
    • Author(s)
      片岡直行、野島孝之、大城-井手上杜子、武内章英、喜井勲、萩原正敏
    • Organizer
      第14回日本RNA学会年会
    • Place of Presentation
      仙台
    • Data Source
      KAKENHI-PROJECT-22603002

  • [Presentation] 今日は治せぬ病を、明日は治せる医師を、京大が育てる2012
    • Author(s)
      萩原正敏
    • Organizer
      京都大学医学部ホームカミングディ
    • Place of Presentation
      京都
    • Year and Date
      2012-11-10
    • Data Source
      KAKENHI-PROJECT-21249013

  • [Presentation] RNAを標的とする創薬で難病に挑む2012
    • Author(s)
      萩原正敏
    • Organizer
      京大医療薬剤学研究会
    • Place of Presentation
      京都
    • Year and Date
      2012-11-17
    • Data Source
      KAKENHI-PROJECT-21249013

  • [Presentation] New chemical screens for drugs of congenital genetic disorders targeting pre-mRNAs2012
    • Author(s)
      Masatoshi Hagiwara
    • Organizer
      Gordon Research Conference
    • Place of Presentation
      Newport, USA
    • Data Source
      KAKENHI-PROJECT-24241076

  • [Presentation] Chemical targeting of RNA processing for new therapeutics of congenital diseases2012
    • Author(s)
      Masatoshi Hagiwara
    • Organizer
      THE 1st official of the INTERNATIONAL CHEMICALBIOLOGY SOCIETY
    • Place of Presentation
      Cambridge,USA
    • Invited
    • Data Source
      KAKENHI-PROJECT-24241076

  • [Presentation] New chemical therapeutics of congenital genetic disorders targeting pre-mRNA2012
    • Author(s)
      Masatoshi Hagiwara
    • Organizer
      日本ケミカルバイオロジー学会第7回年会、国際シンポジウム「新規疾患治療にむけたケミカルバイオロジー研究からの挑戦」
    • Place of Presentation
      京都
    • Year and Date
      2012-06-09
    • Data Source
      KAKENHI-PROJECT-21249013

  • [Presentation] スペックルズ・パラスペックルズに局在するRNA結合蛋白の機能2012
    • Author(s)
      萩原正敏
    • Organizer
      第35回日本分子生物学会
    • Place of Presentation
      福岡
    • Year and Date
      2012-12-11
    • Data Source
      KAKENHI-PROJECT-21249013

  • [Presentation] 国際シンポジウム「新規疾患治療にむけたケミカルバイオロジー研究からの挑戦」2012
    • Author(s)
      萩原　正敏
    • Organizer
      日本ケミカルバイオロジー学会第７回年会
    • Place of Presentation
      京都
    • Invited
    • Data Source
      KAKENHI-PROJECT-24241076

  • [Presentation] Challenges to Congenital Genetic Disorders with "RNA-targeting" Chemical Compounds2012
    • Author(s)
      Masatoshi Hagiwara
    • Organizer
      The 22^<nd> CDB Meeting
    • Place of Presentation
      Kobe
    • Year and Date
      2012-06-11
    • Data Source
      KAKENHI-PROJECT-21249013

  • [Presentation] RNAを標的とする創薬によって難治疾患へ挑む2012
    • Author(s)
      萩原正敏
    • Organizer
      RNAを標的とする創薬によって難治疾患へ挑む
    • Place of Presentation
      京都
    • Invited
    • Data Source
      KAKENHI-PROJECT-24241076

  • [Presentation] ダウン症など先天性難治疾患への挑戦RNAを標的とした創薬の試み2011
    • Author(s)
      萩原正敏
    • Organizer
      第24回近畿小児科学会
    • Place of Presentation
      神戸、国際会議場(招待講演)
    • Year and Date
      2011-03-13
    • Data Source
      KAKENHI-PROJECT-21249013

  • [Presentation] Visuali zation of alternative splicing and the therapeutic manipulation with chemical compounds2011
    • Author(s)
      Masatoshi Hagiwara
    • Organizer
      US - Japan Sumer Conference
    • Place of Presentation
      USA
    • Data Source
      KAKENHI-PROJECT-21249013

  • [Presentation] New therapeutics by alteration of mRNA expression and processing with small chemicals2011
    • Author(s)
      萩原正敏
    • Organizer
      International Chemical Biology Conference
    • Place of Presentation
      Kauffman Foundation Conference, USA
    • Year and Date
      2011-10-12
    • Data Source
      KAKENHI-PROJECT-21249013

  • [Presentation] Modulation of mRNA Splicing with Synthetic Kinase Inhibitors and Their Clinical Applications2011
    • Author(s)
      萩原正敏
    • Organizer
      Protein Kinass Regulating RNA Splicing, 2011
    • Place of Presentation
      ROSCOFF、フランス(招待講演)
    • Year and Date
      2011-11-16
    • Data Source
      KAKENHI-PROJECT-21249013

  • [Presentation] Chemical Treatment enhances skipping of amutated exon in the dystrophin gene2011
    • Author(s)
      片岡直行、西田篤史、竹島泰弘、八木真理子、粟野宏之、大田光徳、伊東恭子、松尾雅文、萩原正敏
    • Organizer
      日本ケミカルバイオロジー学会 第6回年会
    • Place of Presentation
      東京、東京工業大学
    • Year and Date
      2011-05-25
    • Data Source
      KAKENHI-PROJECT-21249013

  • [Presentation] New therapeutics by alteration of mRNA expression and processing with small chemicals"2011
    • Author(s)
      Masatoshi Hagiwara
    • Organizer
      International Chemical Biology Conference
    • Place of Presentation
      USA
    • Data Source
      KAKENHI-PROJECT-21249013

  • [Presentation] Chemical treatment enhances skipping of a mutated exon in the dystrophin gene2011
    • Author(s)
      片岡直行、西田篤史、竹島泰弘、八木麻理子、粟野宏之、大田光徳、伊東恭子、松尾雅文、萩原正敏
    • Organizer
      第6回日本ケミカルバイオロジー学会
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-22603002

  • [Presentation] Chemical treatment of muscular dystrophy that enhances skipping of the mutated exon in the dystrophin gene2011
    • Author(s)
      Kataoka N., Nishida A., Takeshima Y., Yagi M., Awano H., Ota M., Itoh K.,Hagiwara M. and Matsuo M
    • Organizer
      17th Annual Meeting of the RNA Society
    • Place of Presentation
      Kyoto, Japan
    • Data Source
      KAKENHI-PROJECT-22603002

  • [Presentation] Visualization of Alternative Splithin with Multi-color Splicing Reporters and Their Application for Screen of Trans-acting Factors and Small Chemicals2011
    • Author(s)
      萩原正敏
    • Organizer
      The16th Annual Meeting of the RNA Society/The RNA Society of Japan 13^<th> Annual Meeting
    • Place of Presentation
      Kyoto, Japan
    • Data Source
      KAKENHI-PROJECT-21249013

  • [Presentation] Chembiomolecular Medicinal Chemistry2011
    • Author(s)
      萩原正敏
    • Organizer
      第10回上原記念生命科学財団国際シンポジウ「生体制御分子科学」
    • Place of Presentation
      東京、ハイアットリージェンシー東京(招待講演)
    • Year and Date
      2011-06-07
    • Data Source
      KAKENHI-PROJECT-21249013

  • [Presentation] 核内構造体(核スペックル)の形成と選択的スプライシングの低分子化合物による制御2011
    • Author(s)
      松尾陽太、三原由揮、椛本大和、八木浩亮、上原裕也、岩本はる香、萩原正敏, 他
    • Organizer
      日本ケミカルバイオロジー学会第6回年会
    • Place of Presentation
      東京、東京工業大学
    • Year and Date
      2011-05-25
    • Data Source
      KAKENHI-PROJECT-21249013

  • [Presentation] Modulation of pre-mRNA splicing patterns with synthetic chemicals and their clinical applications2011
    • Author(s)
      萩原正敏
    • Organizer
      JST-CRDS主催俯瞰ワークショップ「構造生命科学動的構造情報から創薬へ
    • Place of Presentation
      東京、JST研究開発戦略センター2階大会議室(招待講演)
    • Year and Date
      2011-09-10
    • Data Source
      KAKENHI-PROJECT-21249013

  • [Presentation] RNAを操作して先天性疾患を薬で治す2011
    • Author(s)
      萩原正敏
    • Organizer
      第84回日本生化学会大会
    • Place of Presentation
      京都、京都国際会議場
    • Year and Date
      2011-09-21
    • Data Source
      KAKENHI-PROJECT-21249013

  • [Presentation] Modulation of pre-mRNA splicing patterns with synthetic chemicals and their clinical applications2011
    • Author(s)
      Masatoshi Hagiwara
    • Organizer
      第10回上原記念生命科学財団 国際シンポジウム[生体制御分子科学]
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-21249013

  • [Presentation] Decipherment of splicing code and its manipulation for new therapeutics.2010
    • Author(s)
      萩原正敏
    • Organizer
      2010 RNA国際シンポジウム
    • Place of Presentation
      National Cheng Kung University Medical College(台南)
    • Data Source
      KAKENHI-PROJECT-21249013

  • [Presentation] Splicing resume from stress response2010
    • Author(s)
      Masatoshi Hagiwara
    • Organizer
      Asian Cold Spring Harbor Laboratory 'RNA Biology'
    • Place of Presentation
      Suzhou Dushu Lake Conference Center , China
    • Data Source
      KAKENHI-PROJECT-21249013

  • [Presentation] 蛋白リン酸化酵素を標的とした創薬:ケミカルバイオロジーによるアプローチ2010
    • Author(s)
      萩原正敏
    • Organizer
      平成21年度生命融合科学教育部シンポジウム
    • Place of Presentation
      富山県 高志会館カルチャーホール
    • Year and Date
      2010-03-08
    • Data Source
      KAKENHI-PROJECT-21249013

  • [Presentation] RNA病を斬る/RNAプロセッシング異常に対する創薬の試み2010
    • Author(s)
      萩原正敏
    • Organizer
      オミックス創薬科学セミナー
    • Place of Presentation
      三重大学大学院
    • Year and Date
      2010-01-27
    • Data Source
      KAKENHI-PROJECT-21249013

  • [Presentation] Pre-mRNAスプライシングの組織特異的制御とその異常に起因する疾患2010
    • Author(s)
      萩原正敏
    • Organizer
      大学院セミナー
    • Place of Presentation
      京都大学医学部
    • Year and Date
      2010-09-15
    • Data Source
      KAKENHI-PROJECT-21249013

  • [Presentation] Pre-mRNAスプライシングの組織特異的制御とその異常に起因する疾患2010
    • Author(s)
      萩原正敏
    • Organizer
      北海道大学医学部眼科学講座セミナー
    • Place of Presentation
      北海道大学医学部
    • Year and Date
      2010-09-15
    • Data Source
      KAKENHI-PROJECT-21249013

  • [Presentation] Visualizatio and manipulation of RNA splicing to cure RNA diseases2010
    • Author(s)
      Masatoshi Hagiwara
    • Organizer
      Gorodon Research Conference
    • Place of Presentation
      New port, RI
    • Data Source
      KAKENHI-PROJECT-21249013

  • [Presentation] 新しい分子イメージング技術による創薬2010
    • Author(s)
      萩原正敏
    • Organizer
      第5回ケミカルバイオロジー・第2回センシングバイオロジーシンポジウム
    • Place of Presentation
      東京医科歯科大学 臨床講堂
    • Year and Date
      2010-02-23
    • Data Source
      KAKENHI-PROJECT-21249013

  • [Presentation] Visualization and manipulation of alternative pre-mRNA splicing2010
    • Author(s)
      萩原正敏
    • Organizer
      中国医科大学大学院特別セミナー
    • Place of Presentation
      中国医科大学(瀋陽)
    • Year and Date
      2010-10-14
    • Data Source
      KAKENHI-PROJECT-21249013

  • [Presentation] Visualization and manipulation of mRNA splicing2010
    • Author(s)
      萩原正敏
    • Organizer
      国際生化学分子生物学会
    • Place of Presentation
      上海インターナショナルコンベンションセンター
    • Year and Date
      2010-08-06
    • Data Source
      KAKENHI-PROJECT-21249013

  • [Presentation] Visualizatio and manipulation of RNA splicing to cure RNA diseases2010
    • Author(s)
      萩原正敏
    • Organizer
      Gorodon Research Conference
    • Place of Presentation
      New port, RI, USA(招待講演)
    • Year and Date
      2010-07-23
    • Data Source
      KAKENHI-PROJECT-21249013

  • [Presentation] Splicing resume from stress response2010
    • Author(s)
      萩原正敏
    • Organizer
      Asian Cold Spring Harbor Laboratory 'RNA Biology
    • Place of Presentation
      Suzhou、中国(招待講演)
    • Year and Date
      2010-11-05
    • Data Source
      KAKENHI-PROJECT-21249013

  • [Presentation] Visualization of mRNA splicing by GFP and its chemical manipuiation.(蛍光タンパク質によるmRNAスプライシングの可視化とその制御)2009
    • Author(s)
      萩原正敏
    • Organizer
      日本化学会ノーベル化学賞受賞記念シンポジウム
    • Place of Presentation
      日本大学船橋
    • Year and Date
      2009-03-25
    • Data Source
      KAKENHI-PROJECT-19390071

  • [Presentation] Development of New Protein Kinase Inhibitors and Their Antiviral Effects2009
    • Author(s)
      萩原正敏
    • Organizer
      特別講演
    • Place of Presentation
      ハノイ医科大学、ベトナム
    • Year and Date
      2009-09-04
    • Data Source
      KAKENHI-PROJECT-19390071

  • [Presentation] Session 3「神経疾患におけるスプライシング異常とその制御」2009
    • Author(s)
      萩原正敏
    • Organizer
      第2回グローバルCOE国際シンポジウム
    • Place of Presentation
      ヒルトン名古屋
    • Data Source
      KAKENHI-PROJECT-21249013

  • [Presentation] Deciphering of splicing codes2009
    • Author(s)
      萩原正敏
    • Organizer
      大学院医歯学総合研究科「医歯学先端研究特論」第17～18回GCOE総合国際プレゼンテーション
    • Place of Presentation
      東京医科歯科大学歯学部4階特別講堂
    • Year and Date
      2009-03-23
    • Data Source
      KAKENHI-PROJECT-19390071

  • [Presentation] ケミカルバイオロジーによる難治疾患への挑戦2009
    • Author(s)
      萩原正敏
    • Organizer
      日本薬理学会第81回関東部会
    • Place of Presentation
      東京医科歯科大学 5号館講堂
    • Year and Date
      2009-07-11
    • Data Source
      KAKENHI-PROJECT-21249013

  • [Presentation] 新しい創薬標的:Pre-mRNAスプライシング制御機携とその医学的意義について2009
    • Author(s)
      萩原正敏
    • Organizer
      特別講演
    • Place of Presentation
      三重大学
    • Year and Date
      2009-12-16
    • Data Source
      KAKENHI-PROJECT-19390071

  • [Presentation] リン酸化酵素阻害剤をプローブとした生命現象の解明と新しい創薬標的の発見2009
    • Author(s)
      萩原正敏
    • Organizer
      日本化学会
    • Place of Presentation
      日本大学船橋キャンパス
    • Year and Date
      2009-03-27
    • Data Source
      KAKENHI-PROJECT-19390071

  • [Presentation] Host viral interaction on RNA processing2009
    • Author(s)
      萩原正敏
    • Organizer
      TMDU-CMU国際シンポジウム
    • Place of Presentation
      東京医科歯科大学 歯学部講堂
    • Year and Date
      2009-10-13
    • Data Source
      KAKENHI-PROJECT-21249013

  • [Presentation] ストレス下でのpre-mRNAの選択的スプライシング2009
    • Author(s)
      萩原正敏
    • Organizer
      第82回日本生化学大会シンポジウム
    • Place of Presentation
      神戸ポートアイランド
    • Data Source
      KAKENHI-PROJECT-21249013

  • [Presentation] mRNAスプライシングの分子イメージンダと医療分野への展開2009
    • Author(s)
      萩原正敏
    • Organizer
      第19回大学院セミナー
    • Place of Presentation
      東京医科歯科大学
    • Year and Date
      2009-01-26
    • Data Source
      KAKENHI-PROJECT-19390071

  • [Presentation] 萩原正敏:「創薬に向けた医薬科学を先導する人材の要請2009
    • Author(s)
      萩原正敏
    • Organizer
      RNA結合蛋白リン酸化酵索を標的とする創薬戦略大学教育支援プログラム(大学院GP)
    • Place of Presentation
      慶応大学北里講堂
    • Data Source
      KAKENHI-PROJECT-19390071

  • [Presentation] Visualization of Alternative Splicing of Fibroblast Growth Factor Receptor 2 Revealed the Mutually Exclusive Regulatory Mechanism Cold Spring Harbor Laboratory Meeting2008
    • Author(s)
      Akihide TAKEUCHI, Motoyasu Hosokawa, Masatoshi Hagiwara
    • Organizer
      Eukaryotic mRNA Processing
    • Place of Presentation
      Cold Spring Harbor, New York, U.S.A.
    • Data Source
      KAKENHI-PROJECT-19500269

  • [Presentation] Pre-mRNAの選択的スブライシング制御機構とその医学的意義について2008
    • Author(s)
      萩原正敏
    • Organizer
      特別講演
    • Place of Presentation
      成育医療センター
    • Year and Date
      2008-09-02
    • Data Source
      KAKENHI-PROJECT-19390071

  • [Presentation] スプライシング・レポーターにより明らかになった、哺乳類における組織特異的な相互排他的エクソン選択機構 (「王手飛車」制御メカニズム)2008
    • Author(s)
      武内章英, 細川元靖, 萩原正敏
    • Organizer
      第32回 日本分子生物学会年会
    • Place of Presentation
      パシフイコ横浜
    • Data Source
      KAKENHI-PROJECT-19500269

  • [Presentation] Pre-mRNAの選択的スプライシング制御機構とその異常に起因する疾患2008
    • Author(s)
      萩原正敏
    • Organizer
      大学院セミナー
    • Place of Presentation
      東京大学
    • Year and Date
      2008-09-24
    • Data Source
      KAKENHI-PROJECT-19390071

  • [Presentation] スプライシング・レポーターシステムを用いた、哺乳類における相互排他的エクソン選択機構の解明2008
    • Author(s)
      武内章英、細川元靖、萩原正敏
    • Organizer
      RNAフロンティア・ミーティング2009
    • Place of Presentation
      湘南国際村IPC生産性国際交流センター
    • Data Source
      KAKENHI-PROJECT-19500269

  • [Presentation] Mechanism of Herpesvirus-induced Alternative Splicing of Cellular Genes2008
    • Author(s)
      萩原正敏
    • Organizer
      Gordon Research Conference RNA splicing and discase
    • Place of Presentation
      アメリカ
    • Year and Date
      2008-07-03
    • Data Source
      KAKENHI-PROJECT-19390071

  • [Presentation] Deciphering Splicing Codes Hidden in the Pre-mRNAs Visualization and Manipulation of Alternative Splicing2008
    • Author(s)
      萩原正敏
    • Organizer
      日本分子生物学会
    • Place of Presentation
      神戸
    • Data Source
      KAKENHI-PROJECT-19390071

  • [Presentation] MRNAスプライシング制御機構とウィルスの干渉2008
    • Author(s)
      萩原正敏
    • Organizer
      感染マトリックス研究会
    • Place of Presentation
      名古屋大学医学部
    • Year and Date
      2008-04-05
    • Data Source
      KAKENHI-PROJECT-19041027

  • [Presentation] Visualization of Alternative Splicing of Fibroblast Growth Factor Receptor 2 Revealed the Mutually Exclusive Regulatory Mechanism2008
    • Author(s)
      Akihide TAKEUCHI、 Motoyasu Hosokawa、 Masatoshi Hagiwara
    • Organizer
      Cold Spring Harbor Laboratory Meeting, Eukaryotic mRNA Processing
    • Place of Presentation
      Cold Spring Harbor, New York
    • Data Source
      KAKENHI-PROJECT-19500269

  • [Presentation] New Visualization System to Decipher Splicing Codes Hidden in the Pre-mRNAs2008
    • Author(s)
      萩原正敏
    • Organizer
      特別講演
    • Place of Presentation
      Duke大学
    • Year and Date
      2008-06-27
    • Data Source
      KAKENHI-PROJECT-19390071

  • [Presentation] Visualization and manipulation of alternative splicing of pre-mRNA and application for medical science2008
    • Author(s)
      萩原正敏
    • Organizer
      中国医科大学国際シンポジウム
    • Place of Presentation
      中国済陽
    • Year and Date
      2008-11-27
    • Data Source
      KAKENHI-PROJECT-19390071

  • [Presentation] Fibroblast Growth Factor Receptorをモデルとした、哺乳類における相互排他的エクソン選択機構の解析2008
    • Author(s)
      武内章英、細川元靖、萩原正敏
    • Organizer
      第11回RNAミィーティング
    • Place of Presentation
      新潟市朱鷺メッセ
    • Data Source
      KAKENHI-PROJECT-19500269

  • [Presentation] スプライシング・レポーターにより明らかになった、哺乳類における組織特異的な相互排他的エクソン選択機構(「王手飛車」制御メカニズム)2008
    • Author(s)
      武内章英、細川元靖、萩原正敏
    • Organizer
      第32回日本分子生物学会年会
    • Place of Presentation
      パシフイコ横浜
    • Data Source
      KAKENHI-PROJECT-19500269

  • [Presentation] Fibroblast Growth Factor Receptor をモデルとした、哺乳類における相互排他的エクソン選択機構の解析2008
    • Author(s)
      武内章英, 細川元靖, 萩原正敏
    • Organizer
      第11回 RNAミィーティング
    • Place of Presentation
      新潟市朱鷺メッセ
    • Data Source
      KAKENHI-PROJECT-19500269

  • [Presentation] The expanding world of post-transcriptional regulation on gene expression Visualization and Manipulation of Alternative Splicing of pre-mRNA2008
    • Author(s)
      萩原正敏
    • Organizer
      病態発現機構国際シンポジウム
    • Place of Presentation
      東京医科歯科大学
    • Year and Date
      2008-12-13
    • Data Source
      KAKENHI-PROJECT-19390071

  • [Presentation] ダウン症治療薬の創製2008
    • Author(s)
      萩原正敏
    • Organizer
      第45回日本臨床分子医学会学術集会
    • Place of Presentation
      神戸
    • Year and Date
      2008-07-25
    • Data Source
      KAKENHI-PROJECT-19390071

  • [Presentation] スプライシング・レポーターシステムを用いた、哺乳類における相互排他的エクソン選択機構の解明2008
    • Author(s)
      武内章英, 細川元靖, 萩原正敏
    • Organizer
      RNAフロンティア・ミーティング2009
    • Place of Presentation
      湘南国際村 IPC生産性国際交流センター
    • Data Source
      KAKENHI-PROJECT-19500269

  • [Presentation] 宿主細胞mRNAへのヘルペスウィルス蛋白の干渉機構2007
    • Author(s)
      萩原正敏
    • Organizer
      特定領域研究「感染マトリックス」A01班会議
    • Place of Presentation
      名古屋大学
    • Year and Date
      2007-08-01
    • Data Source
      KAKENHI-PROJECT-19041027

  • [Presentation]2007
    • Author(s)
      萩原正敏
    • Organizer
      日本ケミカルバイオロジー研究会
    • Place of Presentation
      京都大学
    • Year and Date
      2007-05-09
    • Data Source
      KAKENHI-PROJECT-19390071

  • [Presentation] 記録なし2007
    • Author(s)
      萩原 正敏
    • Organizer
      Functional Organization of the Nucleus
    • Place of Presentation
      淡路夢舞台国際会議場
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14035102

  • [Presentation] Cap-binding complex recrits REF to mRNA in a splicing-independent manner for mRNA export2007
    • Author(s)
      Hagiwara M
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14035102

  • [Presentation] mRNAの選択的スプライシング制御因子を標的とした新しい分子治療2007
    • Author(s)
      萩原正敏
    • Organizer
      第13回日本遺伝子治療学会
    • Place of Presentation
      愛知県がんセンター
    • Year and Date
      2007-06-29
    • Data Source
      KAKENHI-PROJECT-19390071

  • [Presentation] Visualization of developmentally regulated alternative splicing events by a GFP/RFP based splicing reporter system2007
    • Author(s)
      萩原 正敏
    • Organizer
      07'遺伝情報DECODE・冬のワークショップ
    • Place of Presentation
      湯沢グランドホテル
    • Year and Date
      2007-01-27
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14035102

  • [Presentation] ケミカルジェネテイクスによるドグマへの挑戦2006
    • Author(s)
      萩原 正敏
    • Organizer
      第80回日本薬理学会年会
    • Place of Presentation
      名古屋国際会議場
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14035102

  • [Presentation] Visualizaition of tissue-specific alternative splicing and cloning of the regulatory proteins in C. elegans2006
    • Author(s)
      Hagiwara M
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14035102

  • [Presentation] Reverse chemical genetics による選択的スプライシング制御機構の解明2006
    • Author(s)
      萩原 正敏
    • Organizer
      日本科学会第86回春季年会
    • Place of Presentation
      日本大学理工学部
    • Year and Date
      2006-03-27
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14035102

  • [Presentation] Alternative splicing a new drug target of the post-genome era2006
    • Author(s)
      Hagiwara M
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14035102

  • [Presentation] SRPKl阻害剤によるリバースケミカルジェネティクス2006
    • Author(s)
      萩原 正敏
    • Organizer
      第8回RNAミーティング
    • Place of Presentation
      淡路夢舞台国際会議場
    • Year and Date
      2006-07-20
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14035102

  • [Presentation] Manipulation of mRNA splicing with Protein Kinasa Inhibitors2006
    • Author(s)
      萩原 正敏
    • Organizer
      第20回国際生化学・分子生物学会議
    • Place of Presentation
      国立京都国際会館
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14035102

  • [Presentation] RNA結合蛋白を標的とする新規抗ウィルス薬開発2006
    • Author(s)
      萩原 正敏
    • Organizer
      大学発新技術説明会
    • Place of Presentation
      大阪科学技術センター
    • Year and Date
      2006-02-24
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14035102

  • [Presentation] Protein kinase inhibitors and their clinical potential2006
    • Author(s)
      Hagiwara M
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14035102

  • [Presentation] Reverse chemical genetics with synthetic protein kinase inhibitors2006
    • Author(s)
      萩原 正敏
    • Organizer
      日本化学会
    • Place of Presentation
      東京
    • Year and Date
      2006-01-27
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14035102

  • [Presentation] 選択的スプライシングのリン酸化制御機構2006
    • Author(s)
      萩原 正敏
    • Organizer
      生物新機能と創薬をめざす生体内分子科学第8回シンポジウム
    • Place of Presentation
      ぱるるプラザ岐阜
    • Year and Date
      2006-01-13
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14035102

  • [Presentation] Molecular manipulation of alternative splicing2006
    • Author(s)
      Hagiwara M
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14035102

  • [Presentation] タンパクリン酸化酵素阻害剤の創薬可能性について2006
    • Author(s)
      萩原 正敏
    • Organizer
      第2回ケミカルバイオロジーフロンティア国際シンポジウム
    • Place of Presentation
      東京医科歯科大学
    • Year and Date
      2006-02-17
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14035102

  • [Presentation] 創薬の未来を開くケミカルバイオロジー2006
    • Author(s)
      萩原 正敏
    • Organizer
      第79回日本薬理学会年会
    • Place of Presentation
      パシフイコ横浜
    • Year and Date
      2006-03-09
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14035102

  • [Presentation] Visualization of tissue-specific alternative splicing and cloning of the regulatory proteins in C. elegans2006
    • Author(s)
      萩原 正敏
    • Organizer
      2006 GRC on Post・Transcriptional Gene regulation, the Biology of
    • Place of Presentation
      オックスフォード大学
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14035102

  • [Presentation] Visualization of tissue-specific alternative splicing and cloning of the regulatory proteins in C. elegans2006
    • Author(s)
      Hidehito Kuroyanagi, Masatoshi Hagiwara
    • Organizer
      Gordon Research Conferences
    • Place of Presentation
      POST-TRANSCRIPTIONAL GENE REGULATION, THE BIOLOGY OF, Oxford, United Kingdom
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14035102

  • [Presentation] Visualization and manipulation of the tissue-specific alternative splicing of mRNA2006
    • Author(s)
      Hagiwara M
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14035102

  • [Presentation] ウィルスRNAを標的とするSRPK阻害剤SRPIN340の創薬2006
    • Author(s)
      萩原 正敏
    • Organizer
      日本ウィルス学会第54回学術集合プログラム
    • Place of Presentation
      名古屋国際会議場
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14035102

  • [Presentation] How to arrest high-jacking of human gene expression system by virus.2005
    • Author(s)
      bHagiwara M.
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14035102

  • [Presentation] Manipulation of alternative splicing by specific inhibitors of SR proteinkinases2005
    • Author(s)
      萩原 正敏
    • Organizer
      4th International Conference on Inhibitors of Protein Kinases
    • Place of Presentation
      ワルシャワ大学カンファレンスサイト グダニスク大学
    • Year and Date
      2005-06-29
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14035102

  • [Presentation] 記録なし2005
    • Author(s)
      萩原 正敏
    • Organizer
      RNA情報網・第3回合同班会議
    • Place of Presentation
      東レ総合研修センター
    • Year and Date
      2005-01-06
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14035102

  • [Presentation] 記録なし2005
    • Author(s)
      萩原 正敏
    • Organizer
      EUKARYOTIC mRNA PROCESSING
    • Place of Presentation
      CSHL
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14035102

  • [Presentation] Manipulation of alternative splicing by specific inhibitors of SR protein kinases. 4th International Conference on Inhibitors of Protein Kinases (IPK 2005)2005
    • Author(s)
      Hagiwara M.
    • Place of Presentation
      Warsaw, Poland
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14035102

  • [Presentation] CaM-K cascade and CREB regulate C. elegans dauer formation. 15th International C.2005
    • Author(s)
      KUROYANAGI H., YOSHIMURA S., KIMURA Y., HAGIWARA M.
    • Organizer
      elegans Conference
    • Place of Presentation
      Los Angeles, CA, USA
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14035102

  • [Presentation] 記録なし2005
    • Author(s)
      萩原 正敏
    • Organizer
      第11回成人病の病因・病態の解明に関する研究会
    • Place of Presentation
      軽井沢プリンスホテル
    • Year and Date
      2005-07-10
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14035102

  • [Presentation] DEVELOPMENT OF A COUPLED IN VITRO TRANSCRIPTION-SPLICING SYSTEM FROM HELA CELL NUCLEAR EXTRACT2005
    • Author(s)
      Takayuki Nojima, Tetsuro Hirose, Masatoshi Hagiwara.
    • Organizer
      Cold Spring Harbor Laboratory Meeting 2005, Eukaryotic mRNA Processing.
    • Place of Presentation
      Cold Spring Harbor, NY, USA.
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14035102

  • [Presentation] How to arrest high-jacking of human gene expression system by virus.2005
    • Author(s)
      萩原 正敏
    • Organizer
      JBSバイオシンポジウム「転写研究の新しいフロンティア」
    • Place of Presentation
      群馬県草津町
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14035102

  • [Presentation] Signal-dependent regulation of SR proteins and its effect on HIV replication. Tenth Annual Meeting of the RNA Society (RNA 2005)2005
    • Author(s)
      Fukuhara T., Hosoya T., Shimizu S. Suzuki M., Yamamoto N., Hagiwara M.
    • Place of Presentation
      Banff, Alberta, Canada
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14035102

  • [Presentation] 特異的リン酸化酵素阻害剤によるリバースケミカルジェネティクスの展開2005
    • Author(s)
      萩原 正敏
    • Organizer
      第3回ケミカルバイオロジーシンポジウム「ケミカルバイオロジー研究の新展開
    • Place of Presentation
      学術総合センター一ツ橋記念講堂
    • Year and Date
      2005-11-09
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14035102

  • [Presentation] CREB研究のOverview・モデル生物を用いたCREB研究2005
    • Author(s)
      萩原 正敏
    • Organizer
      CREB-FORUM
    • Place of Presentation
      京王プラザホテル47階あさひ
    • Year and Date
      2005-05-21
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14035102

  • [Presentation] Chemical Modulators of Alternative Splicing and Their Clinical Application.2004
    • Author(s)
      Hagiwara M.
    • Organizer
      Hirose T. Novel Coupling Mechanism Between Splicing and Intron-Encoded snoRNP Biogenesis. 2. JBS
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14035102

  • [Presentation] SR protein kinese, SPK-1, regulates multiple aspect of post-fertilization development in C.elegans2004
    • Author(s)
      H. Kuroyanagi, M. Hagiwara.
    • Place of Presentation
      2004 East Asia Worm Meeting
    • Year and Date
      2004-06-07
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14035102

  • [Presentation] Dauer Regulatory Functions of CaMK - CREB cascade.2004
    • Author(s)
      S. Yoshimura, H. Kuroyanagi, Y. Kimura, M. Hagiwara.
    • Place of Presentation
      2004 East Asia Worm Meeting
    • Year and Date
      2004-06-07
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14035102

  • [Presentation] 線虫CREBの標的遺伝子の探索 : プロテオームVScDNAマイクロアレイVS In Silico2004
    • Author(s)
      萩原 正敏
    • Organizer
      第3回転写研究会
    • Place of Presentation
      つくば国際会議場
    • Year and Date
      2004-01-17
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14035102

  • [Presentation] 選択的スプライシング : ポストゲノム時代の新しい創薬ターゲット2004
    • Author(s)
      萩原 正敏
    • Organizer
      生物新機能と創薬をめざす生体内分子科学
    • Place of Presentation
      北海道大学
    • Year and Date
      2004-06-29
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14035102

  • [Presentation] 異常スプライシングに起因する疾患の克服に向けて2004
    • Author(s)
      萩原 正敏
    • Organizer
      第27回日本分子生物学会年会
    • Place of Presentation
      ポートピアホテル
    • Year and Date
      2004-12-09
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14035102

  • [Presentation] TG003, specific of Clkl/Sty affects the distribution of nuclear speckles and alternative splicing of mRNAs2004
    • Author(s)
      萩原 正敏
    • Organizer
      第16回国際解剖学会議
    • Place of Presentation
      国立京都国際会館
    • Year and Date
      2004-08-24
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14035102

  • [Presentation] MRNAをターゲットとする新しい抗ウィルス薬の可能性について2004
    • Author(s)
      萩原 正敏
    • Organizer
      「生物新機能と創薬をめざす生体内分子科学」第5回シンポジウム
    • Place of Presentation
      ぱるるプラザ岐阜
    • Year and Date
      2004-01-07
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14035102

  • [Presentation] 記録なし2004
    • Author(s)
      萩原 正敏
    • Organizer
      Dynamic Organization of Nuclear Function ミーティング
    • Place of Presentation
      CSHL
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14035102

  • [Presentation] Chemical Modulators of Alternative Splicing and Their Clinical Application.2004
    • Author(s)
      Hagiwara M.
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14035102

  • [Presentation] Manipulation of alternative splicing by novel kinase inhibitors.2003
    • Author(s)
      Hagiwara M.
    • Organizer
      Opening lecture of the 39^<th> Meeting of the Polish Biochemical Society.
    • Place of Presentation
      Gdansk, Poland.
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14035102

  • [Presentation] 線虫CREB標的遺伝子のプロテオミクス解析2003
    • Author(s)
      萩原 正敏
    • Organizer
      第2回転写研究会
    • Place of Presentation
      つくば国際会議場
    • Year and Date
      2003-01-24
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14035102

  • [Presentation] Understanding the role of RNA processing related PRP4 kinase by identification of its binding proteins.2003
    • Author(s)
      Lechward K., Fukuhara T., Hagiwara M.
    • Organizer
      39^<th> Meeting of the Polish Biochemical Society.
    • Place of Presentation
      Gdansk, Poland.
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14035102

  • [Presentation] 記録なし2003
    • Author(s)
      萩原 正敏
    • Organizer
      特定領域研究「RNA情報網」班会議
    • Place of Presentation
      神戸大学
    • Year and Date
      2003-09-04
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14035102

  • [Presentation] スプライシング異常を伴う疾患群と薬剤による選択的スプライシングの制御2003
    • Author(s)
      萩原 正敏
    • Organizer
      生物新機能と創薬をめざす生体内分子科学第4回シンポジウム
    • Place of Presentation
      メルパルク名古屋
    • Year and Date
      2003-01-08
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14035102

  • [Presentation] Manipulation of alternative splicing by novel kinase inhibitors2003
    • Author(s)
      萩原 正敏
    • Organizer
      Opening lecture of the 39^<th> Meeting of the Polish Biochemical Society
    • Place of Presentation
      Gdansk, Poland
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14035102

  • [Presentation] Signal transduction which regulates mRNA factory.2002
    • Author(s)
      萩原 正敏
    • Organizer
      山中湖カンフアランス
    • Place of Presentation
      東海大学山中湖セミナーハウス
    • Year and Date
      2002-09-07
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14035102

  • [Presentation] MRNAプロセシングのリン酸化制御機構2002
    • Author(s)
      萩原 正敏
    • Organizer
      第75回日本生化学会大会
    • Place of Presentation
      京都宝ヶ池プリンスホテル
    • Year and Date
      2002-10-15
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14035102

  • [Presentation] 線虫プロテオーム解析実施のための具体的プロ世コール受注システムの詳細について2002
    • Author(s)
      萩原 正敏
    • Organizer
      特定領域統合ゲノム線虫分科会発足会議
    • Place of Presentation
      東レ総合研修センター
    • Year and Date
      2002-07-21
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14035102

  • [Presentation] SR protein phosphorylation and virus infection.
    • Author(s)
      Hagiwara M.
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14035102

  • [Presentation] 副作用を示さない新規疼痛治療薬の発見New Drug Discovery for Pain
    • Author(s)
      豊本雅靖、喜井勲、栗原崇、木村亮、小野木博、山本誠、吉田優、細谷孝充、萩原正敏
    • Organizer
      日本ケミカルバイオロジー学会　第9回年会
    • Place of Presentation
      大阪 (大阪大学会館)
    • Year and Date
      2014-06-11 – 2014-06-13
    • Data Source
      KAKENHI-PROJECT-25460723

  • [Presentation] New chemical screens for drugs of congenital genetic disorders targeting pre-mRNAs
    • Author(s)
      Masatoshi Hagiwara
    • Organizer
      Gordon Research Conference
    • Place of Presentation
      Newport, USA
    • Invited
    • Data Source
      KAKENHI-PROJECT-21249013

  • [Presentation] 炎症性疼痛モデルマウスに対するカゼインキナーゼ1(CK1)阻害薬の抗侵害効果
    • Author(s)
      栗原崇、櫻井絵里、豊本雅靖、喜井勲、川元大輔、朝田俊秀、田邊勉、吉村惠、萩原正敏、宮田篤郎
    • Organizer
      第37回日本神経科学大会
    • Place of Presentation
      横浜 (パシフィコ横浜)
    • Year and Date
      2014-09-11 – 2014-09-13
    • Data Source
      KAKENHI-PROJECT-25460723

  • [Presentation] 「Neural development and splicing code」
    • Author(s)
      萩原正敏
    • Organizer
      第３５回日本神経科学大会「RNA結合タンパクと病態シンポジウム」
    • Place of Presentation
      名古屋
    • Invited
    • Data Source
      KAKENHI-PROJECT-21249013

  • [Presentation] Challenges to Congenital Genetic Disorders with "RNA-targeting" Chemical Compounds
    • Author(s)
      Masatoshi Hagiwara
    • Organizer
      The 22nd CDB Meeting
    • Place of Presentation
      神戸
    • Invited
    • Data Source
      KAKENHI-PROJECT-21249013

  • [Presentation] 「 RNAを標的とする創薬によって難治疾患に挑む」
    • Author(s)
      萩原正敏
    • Organizer
      第３６回阿蘇シンポジウム
    • Place of Presentation
      熊本
    • Invited
    • Data Source
      KAKENHI-PROJECT-21249013

  • [Presentation] New chemicaltherapeutics ofcongenital genetic disorders targeting pre-mRNA.
    • Author(s)
      Masatoshi Hagiwara
    • Organizer
      日本ケミカルバイオロジー学会第７回年会、国際シンポジウム「新規疾患治療にむけたケミカルバイオロジー研究からの挑戦」
    • Place of Presentation
      京都
    • Data Source
      KAKENHI-PROJECT-21249013

  • [Presentation] 「スペックルズ・パラスペックルズに局在するＲＮＡ結合蛋白の機能」
    • Author(s)
      萩原正敏
    • Organizer
      第３５回日本分子生物学会
    • Place of Presentation
      福岡
    • Invited
    • Data Source
      KAKENHI-PROJECT-21249013

  • [Presentation] Challenges to congenital genetic disorder with “RNA-targeting” chemical compounds
    • Author(s)
      Masatoshi Hagiwara
    • Organizer
      SLAS2013 2nd Annual Conference & Exhibition
    • Place of Presentation
      ORLAND,FL,USA.
    • Invited
    • Data Source
      KAKENHI-PROJECT-21249013

  • [Presentation] 「プロテオームの多様性創出のメカニズムについて」
    • Author(s)
      萩原正敏
    • Organizer
      HUPOサテライトシンポジウム
    • Place of Presentation
      京都
    • Invited
    • Data Source
      KAKENHI-PROJECT-21249013

  • [Presentation] How to arrest high - jacking of human gene expression system by virus.
    • Author(s)
      Hagiwara M.
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14035102
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