Ohe Kenji 大江賢治

… Alternative Names

OHE Kenji 大江賢治

大江賢治オオエケンジ

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Researcher Number	30419527
Other IDs
Affiliation (Current)	2023: 福岡大学, 薬学部, 教授
Affiliation (based on the past Project Information) *help	2019 – 2021: 福岡大学, 薬学部, 教授 2016 – 2018: 福岡大学, 薬学部, 准教授 2014 – 2016: 京都大学, 健康長寿社会の総合医療開発ユニット, 特定講師 2015: 京都大学, 学内共同利用施設等, 講師 2015: 福岡大学, 薬学部臨床薬物治療学, 准教授 … More 2014: 京都大学, 学際融合教育研究推進センター・健康長寿社会の総合医療開発ユニット, 特定講師 2013: 京都大学, 健康長寿社会の総合医療開発ユニット, 講師 2012: 京都大学, 健康長寿社会の総合医療開発ユニット, 特定講師 2009 – 2011: Fujita Health University, 総合医科学研究所, 准教授 2006: 九州大学, 大学病院, 助手 Less
Review Section/Research Field	Principal Investigator General surgery / Basic Section 56030:Urology-related Except Principal Investigator Endocrinology / Biological Sciences / General pharmacology / Living organism molecular science / Chemical biology / Basic Section 47050:Environmental and natural pharmaceutical resources-related / Basic Section 54040:Metabolism and endocrinology-related / Basic Section 59040:Nutrition science and health science-related
Keywords	Principal Investigator 乳癌 / エストロゲン受容体 / 選択的スプライシング / RNAスプライシング / スプライシング / 内分泌外科学 / ストロゲン受容体 / HMGA1a / 乳腺外科学 / 癌遺伝子産物 … More / RNA結合蛋白質 / 遺伝性乳癌 / 副腎皮質癌 / 治療 / オートファジー / splicing / cancer / adrenal gland / 環状RNA … More Except Principal Investigator 肥満 / スプライシング / 間葉系幹細胞 / アンドロゲン受容体 / アンドロゲン受容体(AR) / シグナル伝達 / Gli1 / 癌 / CRISPR / iPS / アンドロゲン / Ad4BP / SF-1 / アロマターゼ / ステロイド産生細胞 / ステロイド産生細胞再生 / 内分泌攪乱物質 / androgen receptor(AR) / ANT-1 / 1IGF-1 / FoxO 1 / FoxH1 / PPARγ:RXR / NF-kB / 17α-hydroxylase欠損症 / AR異常症 / アンドロゲン過敏症 / KGN細胞 / ELISA / 移植・再生医療 / 遺伝子 / 再生医学 / 発生・分化 / 副腎 / レプチン / 動脈硬化 / 選択的アンドロゲン受容体修飾剤 / DHEA / LOX-1 / 肥満X / SARM / STAT3 / androgen receptor / leptin / obesity / atherosclerosis / selective androgen receutor modulator / dehydroepiandrosterone / 前立腺癌 / アクチビン受容体 / アクチビン / ヘッジホッグ / Smad / 前立腺 / Prostate cancer / Androgen receptor / Activin receptor / 創薬 / 遺伝子発現 / HMGA1 / Presenillin-2 / アルツハイマー病 / Presenilin-2 / 遺伝性疾患 / スプライシング制御 / ポストゲノム創薬 / 遺伝子性疾患 / スプライシング介入ルール / RNA病 / トランスクリプトーム解析 / モデルトランスクリプトーム解析 / RNA病モデル / トランスクリプトーム / kibans / アロマセラピー / 睡眠 / 精油 / ベルガモット / 視索前野 / 青斑核 / 芳香成分 / 睡眠の質 / 睡眠異常 / ストレス / 副腎腫瘍 / 環状RNA / NR5A1 / 副腎皮質 / 小胞体ストレス / サルコペニア / 糖尿病 / コルチゾール / 11β-HSD1 / 老化 / グルココルチコイド Less

アロマセラピーの睡眠促進および睡眠異常改善効果の客観的エビデンスを確立する
- Principal Investigator
  
  村田雄介
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47050:Environmental and natural pharmaceutical resources-related
- Research Institution
  Fukuoka University
ステロイド産生細胞における環状構造RNAの意義の解明
- Principal Investigator
  
  田中智子
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54040:Metabolism and endocrinology-related
- Research Institution
  Fukuoka University
細胞内コルチゾール過剰作用による脂肪・骨格筋・骨の老化進展機構の解明
- Principal Investigator
  
  蘆田健二
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  Kurume University
Developing a novel treatment of adrenocortical carcinoma by a CK2 inhibitorPrincipal Investigator
- Principal Investigator
  
  Ohe Kenji
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56030:Urology-related
- Research Institution
  Fukuoka University
Seeking a novel therapy for hereditary breast cancer by modulating alternative splicingPrincipal Investigator
- Principal Investigator
  
  Ohe Kenji
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General surgery
- Research Institution
  Fukuoka University
  Kyoto University
トランスクリプトームの人為的操作による遺伝病の治療
- Principal Investigator
  
  Hagiwara Masatoshi
- Project Period (FY)
  2015
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  General pharmacology
- Research Institution
  Kyoto University
Therapeutic Drug Discovery and Elucidation of RNA Disease Pathogenesis by Use of CRISPR-Based Disease iPS Cells and Animal Models
- Principal Investigator
  
  Hagiwara Masatoshi
- Project Period (FY)
  2015 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Research Field
  
  Chemical biology
- Research Institution
  Kyoto University
Exploring a novel therapy of hormone-resistant breast cancer by short RNAPrincipal Investigator
- Principal Investigator
  
  OHE Kenji
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General surgery
- Research Institution
  Kyoto University
Global disorder of splicing caused by oncogene product HMGA1
- Principal Investigator
  
  MAYEDA Akila
- Project Period (FY)
  2012 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Living organism molecular science
- Research Institution
  Fujita Health University
Regulation of Estrogen Receptor Alpha through novel function of HMGA1a.-Towards a novel breast cancer therapy-Principal Investigator
- Principal Investigator
  
  OHE Kenji
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General surgery
- Research Institution
  Fujita Health University
Regeneration of adrenal gland by soluble factor
- Principal Investigator
  
  OKABE Taijiro
- Project Period (FY)
  2006 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Endocrinology
- Research Institution
  Kyushu University
Roles of activin and hedgehog signaling in the androgen-independent prostate cancer cells
- Principal Investigator
  
  NOMURA Masatoshi
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Endocrinology
- Research Institution
  Kyushu University
Molecular mechanism in the control of central obesity and atherosclerosis by androgen and its target molecule
- Principal Investigator
  
  NAWATA Hajime
- Project Period (FY)
  2005 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Research Field
  
  Endocrinology
- Research Institution
  Kyushu University
Basic and clinical research on abnormalities of sexual differentiation associated with synthesis and action of sex steroids
- Principal Investigator
  
  YANASE Toshihiko
- Project Period (FY)
  2004 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Kyushu University

[Book] スプライシング　生体の科学　特集　細胞シグナル操作法　II.　機能からみたシグナル操作法2015
- Author(s)
  大江賢治、飯田慶、萩原正敏
- Total Pages
  2
- Publisher
  金原一郎医学医療振興財団
- Data Source
  KAKENHI-PROJECT-15K10050
[Book] 選択的スプライシング・ネットワークを化合物で操作する。2015
- Author(s)
  大江賢治、萩原正敏
- Total Pages
  5
- Publisher
  医学書院
- Data Source
  KAKENHI-PROJECT-15H05721
[Book] 選択的スプライシング・ネットワークを化合物で操作する　生体の科学　特集「細胞を化学で観察する・操作する」2015
- Author(s)
  大江賢治、萩原正敏
- Total Pages
  5
- Publisher
  金原一郎医学医療振興財団
- Data Source
  KAKENHI-PROJECT-15K10050
[Book] BIO Clinica　BIOLOGY TOPICS 選択的スプライシングを標的とした低分子化合物の医薬品開発2014
- Author(s)
  大江賢治、萩原正敏
- Total Pages
  6
- Publisher
  北隆館
- Data Source
  KAKENHI-PROJECT-24591920
[Journal Article] ヒト副腎皮質に発現しているIREタイプの新規環状RNAの発見2021
- Author(s)
  田中智子、大江賢治
- Journal Title
  
  Medical Science Digest
  
  Volume: 47 Pages: 117-118
- Data Source
  KAKENHI-PROJECT-20K08922
[Journal Article] 副腎皮質癌治療の標的分子としての核内受容体NR5A1(SF-1/Ad4BP)2021
- Author(s)
  大江賢治, 堀田裕太, 田中智子
- Journal Title
  
  糖尿病・内分泌代謝科
  
  Volume: 53巻1号 Pages: 85-89
- NAID
  40022653129
- Data Source
  KAKENHI-PROJECT-20K08922
[Journal Article] An Open-label Phase I/IIa Clinical Trial of 11β-HSD1 Inhibitor for Cushing’s Syndrome and Autonomous Cortisol Secretion2021
- Author(s)
  Oda Satoko、Ashida Kenji、Uchiyama Makiko、Sakamoto Shohei、Hasuzawa Nao、Nagayama Ayako、Wang Lixiang、Nagata Hiromi、Sakamoto Ryuichi、Kishimoto Junji、Todaka Koji、Ogawa Yoshihiro、Nakanishi Yoichi、Nomura Masatoshi
- Journal Title
  
  The Journal of Clinical Endocrinology & Metabolism
  
  Volume: 106
- DOI
  10.1210/clinem/dgab450
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K08921, KAKENHI-PROJECT-20K11617
[Journal Article] In Vitro Disease Modeling of Hermansky-Pudlak Syndrome Type 2?Using Human Induced Pluripotent Stem Cell-Derived Alveolar Organoids2019
- Author(s)
  Korogi Yohei、Gotoh Shimpei、Ikeo Satoshi、Yamamoto Yuki、Sone Naoyuki、Tamai Koji、Konishi Satoshi、Nagasaki Tadao、Matsumoto Hisako、Ito Isao、Chen-Yoshikawa Toyofumi F.、Date Hiroshi、Hagiwara Masatoshi、Asaka Isao、Hotta Akitsu、Mishima Michiaki、Hirai Toyohiro
- Journal Title
  
  Stem Cell Reports
  
  Volume: 13 Pages: 235-235
- DOI
  10.1016/j.stemcr.2019.05.022
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05721
[Journal Article] In Vitro Disease Modeling of Hermansky-Pudlak Syndrome Type 2 Using Human Induced Pluripotent Stem Cell-Derived Alveolar Organoids.2019
- Author(s)
  Korogi Yohei、Gotoh Shimpei、Ikeo Satoshi、Yamamoto Yuki、Sone Naoyuki、Tamai Koji、Konishi Satoshi、Nagasaki Tadao、Matsumoto Hisako、Ito Isao、Chen-Yoshikawa Toyofumi F.、Date Hiroshi、Hagiwara Masatoshi、Asaka Isao、Hotta Akitsu、Mishima Michiaki、Hirai Toyohiro
- Journal Title
  
  Stem Cell Reports
  
  Volume: 12 Pages: 431-440
- DOI
  10.1016/j.stemcr.2019.01.014
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H05084, KAKENHI-PROJECT-17H04183, KAKENHI-PROJECT-15H05721
[Journal Article] Circular IRE-type RNAs of the NR5A1 gene are formed in adrenocortical cells2019
- Author(s)
  Ohe Kenji、Tanaka Tomoko、Horita Yuta、Harada Yoshihiro、Yamasaki Takafumi、Abe Ichiro、Tanabe Makito、Nomiyama Takashi、Kobayashi Kunihisa、Enjoji Munechika、Yanase Toshihiko
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 512 Pages: 1-6
- DOI
  10.1016/j.bbrc.2019.02.151
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15H05721, KAKENHI-PROJECT-16K09815, KAKENHI-PROJECT-18K09212
[Journal Article] Human Sox4 facilitates the development of CXCL13-producing helper T cells in inflammatory environments.2018
- Author(s)
  Yoshitomi H, Kobayashi S, Miyagawa-Hayashino A, Okahata A, Doi K, Nishitani K, Murata K, Ito H, Tsuruyama T, Haga H, Matsuda S, Toguchida J
- Journal Title
  
  Nat Commun
  
  Volume: 9 Pages: 3762-3762
- DOI
  10.1038/s41467-018-06187-0
- NAID
  120006523829
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K15663, KAKENHI-PROJECT-15H05721, KAKENHI-PROJECT-17H04059, KAKENHI-PROJECT-18H02926, KAKENHI-PROJECT-18H02929, KAKENHI-PROJECT-17K19725
[Journal Article] Development of an orally available inhibitor of CLK1 for skipping a mutated dystrophin exon in Duchenne muscular dystrophy.2017
- Author(s)
  SakoY, Ninomiya K, Okuno Y, Toyomoto M, Nishida A, KoikeY, Ohe K, Kii I, Yoshida S, Hashimoto N, Hosoya T, Matsuo M, and Hagiwara M
- Journal Title
  
  Sci Rep
  
  Volume: 7 Pages: 46126-46126
- DOI
  10.1038/srep46126
- NAID
  120006355767
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H05721, KAKENHI-PROJECT-15K10050, KAKENHI-PROJECT-21249013
[Journal Article] RBM24 promotes U1 snRNP recognition of the mutated 5' splice site in the IKBKAP gene of familial dysautonomia.2017
- Author(s)
  Ohe K, Yoshida M, Nakano-Kobayashi A, Hosokawa M, Sako Y, Sakuma M, Okuno Y, Usui t, Ninomiya K, Nojima T, Kataoka N, and Hagiwara M.
- Journal Title
  
  RNA
  
  Volume: 23 Issue: 9 Pages: 1393-1403
- DOI
  10.1261/rna.059428.116
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H05721, KAKENHI-PROJECT-15K10050, KAKENHI-PROJECT-21249013
[Journal Article] Competitive regulation of alternative splicing and alternative polyadenylation by hnRNP H and CstF64 determines acetylcholinesterase isoforms.2017
- Author(s)
  Nazim M, Masuda A, Rahman MA, Nasrin F, Takeda JI, Ohe K, Ohkawara B, Ito M, Ohno K.
- Journal Title
  
  Nucleic Acids Res.
  
  Volume: - Pages: 1455-1455
- DOI
  10.1093/nar/gkw823
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04840, KAKENHI-PROJECT-25430049, KAKENHI-PROJECT-15K06707, KAKENHI-PROJECT-15K10050, KAKENHI-PROJECT-15K06755
[Journal Article] Rectifier of aberrant mRNA splicing recovers tRNA modification in familial dysautonomia.2015
- Author(s)
  Yoshida M, Kataoka N, Miyauchi K, Ohe K, Iida K, Yoshida S, Nojima T, Okuno Y, Onogi H, Usui T, Takauchi A, Hosoya T, Suzuki T, and Hagiwara M
- Journal Title
  
  Proc Natl Acad Sci USA.
  
  Volume: 112（9） Issue: 9 Pages: 2764-2769
- DOI
  10.1073/pnas.1415525112
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24241076, KAKENHI-PROJECT-25620125, KAKENHI-PROJECT-26220205, KAKENHI-PROJECT-15K10050, KAKENHI-PLANNED-26113003, KAKENHI-PROJECT-15H05721, KAKENHI-PROJECT-21249013
[Journal Article] CHCHD2 mutations in autosomal dominant late-onset Parkinson's disease: a genome-wide linkage and sequencing study.2015
- Author(s)
  Funayama M, Ohe K, Amo T, Furuya N, Yamaguchi J, Saiki S, Yuanzhe L, Ogaki K, Ando M, Yoshinon H, Tomiyama H, Nishioka K, Hasegawa K, Saiki H, Satake W, Mogushi K, Sasaki R, Kokubo Y, Kuzuhara S, Toda T, Mizuno Y, Uchiyama Y, Ohno K, Hattori N.
- Journal Title
  
  The Lancet Neurology
  
  Volume: 14 Pages: 274-282
- DOI
  10.1016/s1474-4422(14)70266-2
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PLANNED-22129006, KAKENHI-PROJECT-24390224, KAKENHI-PROJECT-24500868, KAKENHI-PROJECT-24790903, KAKENHI-PUBLICLY-25110720, KAKENHI-ORGANIZER-25111001, KAKENHI-PLANNED-25111007, KAKENHI-PUBLICLY-25129707, KAKENHI-PROJECT-25461291, KAKENHI-PROJECT-25461292, KAKENHI-PROJECT-25670420, KAKENHI-PROJECT-25713015, KAKENHI-PROJECT-25860725, KAKENHI-PROJECT-25860726, KAKENHI-PROJECT-26253057, KAKENHI-PROJECT-26870175, KAKENHI-PROJECT-15K10050, KAKENHI-ORGANIZER-23111001, KAKENHI-PLANNED-23111003, KAKENHI-PLANNED-23111004, KAKENHI-PROJECT-25257507, KAKENHI-PROJECT-15H04842, KAKENHI-PROJECT-25305030
[Journal Article] Modulation of alternative splicing with chemical compounds in new therapeutics for human diseases.2015
- Author(s)
  Ohe K, Hagiwara M.
- Journal Title
  
  ACS chemical biology
  
  Volume: 10 Pages: 914-924
- DOI
  10.1021/cb500697f
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K10050
[Journal Article] HnRNP L and hnRNP LL antagonistically modulate PTB-mediated splicing suppression of CHRNA1 pre-mRNA2013
- Author(s)
  Rahman, M. A., Masuda, A., Ohe, K., Ito, M. , Hutchinson, D. O., Mayeda, A., Engel, A. G. and Ohno, K.
- Journal Title
  
  Scientific Reports
  
  Volume: 3 Pages: 1-11
- DOI
  10.1038/srep02931
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23700422, KAKENHI-PROJECT-24390221, KAKENHI-PROJECT-24500469, KAKENHI-PROJECT-24591920, KAKENHI-PROJECT-25430049, KAKENHI-PROJECT-25670164
[Journal Article] Nested introns in an intron : Evidence of multi-step splicing in a large intron of the human dystrophin pre-mRNA.2013
- Author(s)
  Suzuki, H., Kameyama, T., Ohe, K. Tsukahara, T., Mayeda, A.
- Journal Title
  
  FEBS Lett.
  
  Volume: 587 Pages: 555-561
- DOI
  10.1016/j.febslet.2013.01.057
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-23112722, KAKENHI-PROJECT-24591920, KAKENHI-PROJECT-24700974, KAKENHI-PROJECT-25290072, KAKENHI-PROJECT-25640081
[Journal Article] Intronic and exonic nucleotide variations that affect RNA splicing in humans.2013
- Author(s)
  K. Ohe, A. Masuda & K. Ohno.
- Journal Title
  
  iConcept Press. Sequence and Genome Analysis I
  
  Volume: in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591920
[Journal Article] Equal contribution to first author and corresponding author. HMGA1a is involved in specific splice site regulation of human immunodeficiency virus type 12011
- Author(s)
  Tsuruno C, Ohe K, Kuramitsu M, Kohma T, Takahama Y, Hamaguchi Y, Hamaguchi I, Okuma K
- Journal Title
  
  Biochem. Biophys. Res. Commun
  
  Volume: 406 Pages: 512-517
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591679
[Journal Article] HMGA1a is involved in specific splice site regulation of human immunodeficiency virus type 12011
- Author(s)
  Tsuruno C, Ohe K, Kuramitsu M, Kohma T, Takahama Y, Hamaguchi Y, Hamaguchi I, Okuma K
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: (印刷中)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591679
[Journal Article] HMGA1a trapping of U1 snRNP at an authentic 5' splice site induces aberrant exon skipping in sporadic Alzheimer's disease2010
- Author(s)
  大江賢治, 前田明
- Journal Title
  
  Molecular and Cellular Biology (印刷中)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591679
[Journal Article] MGA1a trapping of U1 snRNP at an authentic 5' splice site induces aberrant exon skipping in sporadic Alzheimer's disease2010
- Author(s)
  Ohe K, Mayeda A
- Journal Title
  
  Molecular and Cellular Biology
  
  Volume: 30 Pages: 2220-2228
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591679
[Journal Article] HMGA1a trapping of U1 snRNP at an authentic 5' splice site induces aberrant exon skipping in sporadic Alzheimer's disease.2010
- Author(s)
  Ohe K, Mayeda A
- Journal Title
  
  Molecular and Cellular Biology
  
  Volume: 30 Pages: 2220-2228
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591679
[Journal Article] DAX-1 and SOX6 molecular interplay results in an antagonistic effect in pre-mRNA splicing2009
- Author(s)
  Ohe K, Tamai KT, Parvinen M, Sassone-Corsi P.
- Journal Title
  
  Developmental Dynamics 238
  
  Pages: 1595-1604
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591679
[Journal Article] Sassone-Corsi P. DAX-1 and SOX6 molecular interplay results in an antagonistic effect in pre-mRNA splicing2009
- Author(s)
  Ohe K, Tamai KT, Parvinen M
- Journal Title
  
  Developmental Dynamics
  
  Volume: 238 Pages: 1595-1604
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591679
[Journal Article] がん遺伝子産物HMGA1aがひき起こす孤発性アルツハイマー病の異常スプライシング2009
- Author(s)
  前田明, 眞部孝幸, 大江賢治
- Journal Title
  
  蛋白質核酸酵素 54(12月増刊号)
  
  Pages: 2245-2250
- Data Source
  KAKENHI-PROJECT-21591679
[Journal Article] がん遺伝子産物HMGA1aがひき起こす孤発性アルツハイマー病の異常スプライシング2009
- Author(s)
  田明, 眞部孝幸, 大江賢治
- Journal Title
  
  蛋白質核酸酵素
  
  Volume: 54(12月増刊号) Pages: 2245-2250
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591679
[Journal Article] Methylation of a conserved intronic CpG island of mouse SF-1 is associated with cell-specific expression of SF-1 in a culture system but not with tissue-specific expression2008
- Author(s)
  Shiirohzu, H., Okabe, T., Gondo, S., Tanaka, T., Ohe, K., Morinaga, H., Kawate, H., Nomura, M., Takayanagi, R., Nawata, H., Yanase, T
- Journal Title
  
  Biochem Biophys Res Commun 369
  
  Pages: 862-867
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16086207
[Journal Article] Methylation of a conserved intronic CpG island of mouse SF-1 is associated with cell-specific expression of SF-1 in a culture system but not with tissue-specific expression2008
- Author(s)
  Shirohzu H, Okabe T, Gondo S, Tanaka T, Ohe K, Morinaga H, Kawate H, Nomura M, Takayanagi R, Nawata H, Yanase T
- Journal Title
  
  Biochem Biophys Res Commun 369
  
  Pages: 862-867
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16086207
[Journal Article] Steroidogenic factorl/adrenal 4 binding protein transforms human bone marrow mesenchymal cells into steroidogenic cells.2007
- Author(s)
  Tanaka T, Gondo S, Okabe T, Ohe K, Shirohzu H, Morinaga H, Nomura M, Tani K, Takayanagi R, Nawata H, Yanase T
- Journal Title
  
  J. Mol. Endocrinol 39
  
  Pages: 343-350
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18591029
[Journal Article] Steroidogenic factor 1/adrenal 4 binding protein transforms human bone marrow mesenchymal cells into steroidogenic cells.2007
- Author(s)
  Tanaka T, Gondo S, Okabe T, Ohe K, Shirohzu H, Morinaga H, Nomura M, Tani K, Takayanagi R, Nawata H, Yanase T
- Journal Title
  
  J. Mol. Endocrinol. 39
  
  Pages: 343-350
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591029
[Journal Article] Steroidogenic factor 1/adrenal 4 binding protein transforms human bone marrow mesenchymal cells into steroidogenic cells2007
- Author(s)
  Tanaka, T., Gondo, S., Okabe, T., Ohe, K., S hirohzu, H., Morinaga, H., Nomura, M., Tani, K ., Takayanagi, R., Nawata, H., Yanase, T.
- Journal Title
  
  J Mol Endocrinol 39
  
  Pages: 343-350
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18591028
[Journal Article] Steroidogenic factor 1/adrenal 4 binding protein transforms human bone marrow mesenchymal cells into steroidogenic cells2007
- Author(s)
  Tanaka, T., Gondo, S., Okabe, T., Ohe, K., Shirohzu, H., Morinaga, H., Nomura, M., Tani, K., Takayanagi, R., Nawata, H., Yanase, T
- Journal Title
  
  J Mol Endocrinol 39
  
  Pages: 343-350
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16086207
[Journal Article] Differntiation and regeneration of adrenal tissues : an initial step toward regeneration therapy for steroid insufficiency.2006
- Author(s)
  Yanase T, Gondo S, Okabe T, Tanaka T, Shirohzu H, Fan W, Oba K, Morinaga H, Nomura M, Ohe K, Nawata H
- Journal Title
  
  Endocr J 53
  
  Pages: 449-459
- Data Source
  KAKENHI-PROJECT-18591029
[Journal Article] Differentiation and regeneration of adrenal tissues : An initial step toward regeneration therapy for steroid insufficiency2006
- Author(s)
  Yanase,T.,Gondo,S.,Okabe,T.,Tanaka,T .,Shirohzu,H.,Fan,W.,Oba,K.,Morinaga,H. ,Nomura,M.,Ohe,K.,Nawata,H
- Journal Title
  
  Endocr Journal 53
  
  Pages: 449-459
- NAID
  10019269571
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18591028
[Patent] ＮＲ５Ａ１発現抑制剤および医薬組成物2018
- Inventor(s)
  田中智子、大江賢治、柳瀬敏彦
- Industrial Property Rights Holder
  田中智子、大江賢治、柳瀬敏彦
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2018-038982
- Filing Date
  2018
- Data Source
  KAKENHI-PROJECT-18K09212
[Presentation] MIN6細胞においてスプライシング操作薬が誘導するPax6スプライシングバリアント2022
- Author(s)
  田中智子, 前田幸彦, 大江賢治, 小玉正太
- Organizer
  日本内分泌学会
- Data Source
  KAKENHI-PROJECT-20K08922
[Presentation] MIN6細胞においてスプライシング操作薬が誘導するPax6スプライシングバリアント2021
- Author(s)
  前田幸彦, 田中智子, 大江賢治, 小玉正太
- Organizer
  日本分子生物学会
- Data Source
  KAKENHI-PROJECT-20K08922
[Presentation] 低濃度メトホルミンによるエストロゲン受容体アルファ選択的スプライシングのタモキシフェン反応性変化2021
- Author(s)
  原田義広, 田中智子, 大江賢治
- Organizer
  日本癌学会
- Data Source
  KAKENHI-PROJECT-20K08922
[Presentation] 副腎皮質癌の新規治療標的としてのNR5A1の複数エキソン除外制御機構2020
- Author(s)
  田中智子, 大江賢治, 遠城寺宗近, 小玉正太, 柳瀬敏彦
- Organizer
  第93回日本内分泌学会学術集会シンポジウム SY2-4.
- Data Source
  KAKENHI-PROJECT-18K09212
[Presentation] NR5A1 RNAのスプライシング調節を介したNR5A1発現抑制：各種薬剤の検討2020
- Author(s)
  田中智子、大江賢治、小玉正太、柳瀬敏彦
- Organizer
  第93回日本内分泌学会学術総会
- Data Source
  KAKENHI-PROJECT-20K08922
[Presentation] 20.CX-4945 as a novel adrenocortical carcinoma drug that induces multiple exon-skipping and circular RNA of NR5A1.2019
- Author(s)
  Tomoko Tanaka, Kenji Ohe, Takashi Nomiyama, Toshihiko Yanase.
- Organizer
  ENDO2019,
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K09212
[Presentation] CX-4945 as a novel adrenocortical carcinoma drug that induces multiple exon-skipping and circular RNA of NR5A12019
- Author(s)
  Tanaka T, Ohe K, Nomiyama T, Yanase T
- Organizer
  ENDO2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K09212
[Presentation] ヒト副腎皮質に発現しているIREタイプの新規環状RNAの発見2019
- Author(s)
  大江賢治、堀田裕太、田中智子、原田義広、森征慶、村田雄介、遠城寺宗近、柳瀬敏彦
- Organizer
  第42回　日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-18K09212
[Presentation] CX-4945 is a novel candidate for the treatment of adrenocortical tumors2018
- Author(s)
  Tanaka T, Ohe K, Abe I, Kobayashi K, Enjoji M, Yanase T
- Organizer
  20th European Congress of Endocrinology (Barcelona, Spain)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K09212
[Presentation] CX-4945はH295R細胞の増殖およびホルモン産生を抑制する2018
- Author(s)
  田中智子、大江賢治、阿部一朗、小林邦久、柳瀬敏彦
- Organizer
  第91回日本内分泌学会学術総会
- Data Source
  KAKENHI-PROJECT-18K09212
[Presentation] Duchenne型筋ジストロフィーに対して変異ジストロフィンエキソンのスキッピング誘導活性を有する経口投与可能な新規CLK1阻害剤の開発2017
- Author(s)
  佐古有季哉、二宮賢介、奥野友紀子、豊本雅靖、西田篤史、小池悠華、大江賢治、喜井勲、吉田優、橋本有弘、細谷孝充、松尾雅文、萩原正敏
- Organizer
  2017年度　生命科学系学会合同年次大会
- Data Source
  KAKENHI-PROJECT-15H05721
[Presentation] Development of an orally available inhibitor of CLK1 for skipping a mutated dystrophin exon in Duchenne muscular dystrophy.2017
- Author(s)
  佐古有季哉、二宮賢介、奥野友紀子、豊本雅靖、西田篤史、小池悠華、大江賢治、喜井勲、吉田優、橋本有弘、細谷孝充、松尾雅文、萩原正敏
- Organizer
  International Chemical Biology Society 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05721
[Presentation] Duchenne型筋ジストロフィーに対するエキソンスキッピング治療薬候補化合物である新規CLK1特異的阻害剤2016
- Author(s)
  佐古有季哉、二宮賢介、奥野友紀子、豊本雅靖、西田篤史、小池悠華、大江賢治、喜井勲、吉田優、細谷孝充、松尾雅文、萩原正敏
- Organizer
  日本ケミカルバイオロジー学会　第11回年会
- Data Source
  KAKENHI-PROJECT-15H05721
[Presentation] HMGA1aに対する「おとり」RNAは、エストロゲン受容体の選択的スプライシングを制御する2016
- Author(s)
  大江賢治，内海俊明，前田明，遠城寺宗近
- Organizer
  第2回核酸医薬学会
- Place of Presentation
  東京理科大学葛飾キャンパス
- Year and Date
  2016-11-15
- Data Source
  KAKENHI-PROJECT-15K10050
[Presentation] RBM24 IS RESPONSIBLE FOR TISSUE-SPECIFIC ABERRANT SPLICING IN FAMILIAL DYSAUTONOMIA2015
- Author(s)
  Kenji Ohe, Mayumi Yoshida, Kensuke Ninomiya, Maki Sakuma, Tomomi Usui, Takayuki Nojima, Naoyuki Kataoka, Masatoshi Hagiwara
- Organizer
  CSHL Eukaryotic mRNA Processing, 2015 Oral presentation
- Place of Presentation
  Cold Spring Harbor Laboratory, NY
- Year and Date
  2015-08-18
- Data Source
  KAKENHI-PROJECT-15H02505
[Presentation] 家族性自律神経失調症におけるIKBKAP遺伝子の組織特異的異常スプライシングの責任分子の同定2015
- Author(s)
  大江賢治、吉田真弓、二宮賢介、佐久間真紀、薄井知美、野島孝之、萩原正敏、片岡直行
- Organizer
  第17回日本RNA学会年会　口頭発表
- Place of Presentation
  ホテルライフォート札幌
- Year and Date
  2015-07-15
- Data Source
  KAKENHI-PROJECT-15H02505
[Presentation] Identification of RNA-binding proteins responsible for aberrant tissue-specific splicing of the IKBKAP gene in Familial dysautonomia2015
- Author(s)
  Kenji Ohe, Mayumi Yoshida, Akiko Nakano-Kobayashi, Kensuke Ninomiya, Maki Sakuma, Tomomi Usui, Takayuki Nojima, Naoyuki Kataoka, Masatoshi Hagiwara
- Organizer
  第17 回日本RNA 学会年会
- Place of Presentation
  札幌市、北海道
- Year and Date
  2015-07-15
- Data Source
  KAKENHI-PROJECT-15K10050
[Presentation] Identification of RNA-binding proteins responsible for aberrant tissue-specific splicing of the IKBKAP gene in Familial dysautonomia2015
- Author(s)
  Kenji Ohe, Mayumi Yoshida, Akiko Nakano-Kobayashi, Kensuke Ninomiya, Maki Sakuma, Tomomi Usui, Takayuki Nojima, Naoyuki Kataoka, Masatoshi Hagiwara
- Organizer
  EUKARYOTIC mRNA PROCESSING meeting 2015, Cold Spring Harbor Laboratory
- Place of Presentation
  New York, USA
- Year and Date
  2015-08-18
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K10050
[Presentation] Sequence-specific RNA-binding of HMGA1a may play a role in acquired resistance of estrogen receptor-positive breast carcinoma2013
- Author(s)
  Ohe K, Miyajima S, Kuwasako K, Muto Y, Utsumi T, Hagiwara M, Mayeda A
- Organizer
  Eukaryotic mRNA Processing Meeting
- Place of Presentation
  Cold Spring Harbor Laboratory, USA
- Data Source
  KAKENHI-PROJECT-24310161
[Presentation] Sequence-specific RNA-binding of HMGA1a may play a role in acquired resistance of estrogen receptor-positive breast carcinoma2013
- Author(s)
  Kenji Ohe, Shinsuke Miyajima, Kanako Kuwasako, Yutaka Muto, Toshiaki Utsumi, Masatoshi Hagiwara, Akila Mayeda
- Organizer
  2013 CSHL Meeting on Eukaryotic mRNA Processing
- Place of Presentation
  コールドスプリングハーバー、ニューヨーク、米国
- Data Source
  KAKENHI-PROJECT-24591920
[Presentation] HMGA1に対する「おとり」RNAは、エストロゲン受容体アルファ-46（ERα46）の選択的スプライシング改変により腫瘍増殖を促進する2012
- Author(s)
  大江賢治、宮島慎介、内海俊明
- Organizer
  第85回　日本内分泌学会学術総会
- Place of Presentation
  名古屋国際会議場
- Data Source
  KAKENHI-PROJECT-24591920
[Presentation] 乳癌における癌遺伝子産物HMGA1aによるERα46 の発現調節機構2012
- Author(s)
  宮島慎介、大江賢治、牛窓かおり、引地理浩、小林尚美、前田明、内海俊明
- Organizer
  第20回　日本乳癌学会学術総会
- Place of Presentation
  熊本市民会館
- Data Source
  KAKENHI-PROJECT-24591920
[Presentation] A Novel Sequence Signal That Promotes Pre-mRNA Splicing without U1 snRNP2011
- Author(s)
  Kenji Ohe, Eiji Sakashita, Hitoshi Endo, Akila Mayeda
- Organizer
  第16回RNA society国際会議
- Place of Presentation
  国立京都国際会館
- Year and Date
  2011-06-15
- Data Source
  KAKENHI-PROJECT-21591679
[Presentation] Regulating Cancer-Associated Alternative Splicing by Decoy RNA2011
- Author(s)
  Kenji Ohe
- Organizer
  第70回日本癌学会学術総会
- Place of Presentation
  名古屋国際会議場
- Year and Date
  2011-10-03
- Data Source
  KAKENHI-PROJECT-21591679
[Presentation] HMGA1に対する「おとり」RNAは、エストロゲン受容体αの異常スプライシングを是正する2010
- Author(s)
  大江賢治、内海俊明、前田明
- Organizer
  第18回日本ステロイドホルモン学会年会
- Place of Presentation
  名古屋市、WINC AICHI
- Year and Date
  2010-11-27
- Data Source
  KAKENHI-PROJECT-21591679
[Presentation] HMGA1a induces aberrant splicing of Estrogen Receptor α in MCF-7 breast cancer cells2010
- Author(s)
  Kenji Ohe, Toshiaki Utsumi, Akila Mayeda
- Organizer
  第6回国際ホルモン依存性癌シンポジウム
- Place of Presentation
  シエラトン・グランデ・トーキョーベイ・ホテル
- Year and Date
  2010-09-12
- Data Source
  KAKENHI-PROJECT-21591679
[Presentation] HMGA1a induces aberrant splicing of Estrogen Receptor α in MCF-7 breast cancer cells2010
- Author(s)
  大江賢治, 内海俊明, 前田明
- Organizer
  14th International Congress of Endocrinology
- Place of Presentation
  京都市、国立京都国際会館
- Data Source
  KAKENHI-PROJECT-21591679
[Presentation] ヒト免疫不全ウイルス特異的なスプライシングに必要な新しい宿主因子の解析2010
- Author(s)
  大江賢治、鶴野親是、倉光球、高浜洋一、浜口功、大隈和、前田明
- Organizer
  第12回日本RNA学会年会
- Place of Presentation
  東京、学術総合センター一ツ橋記念講堂
- Data Source
  KAKENHI-PROJECT-21591679
[Presentation] ヒト免疫不全ウイルス特異的なスプライシングに必要な新しい宿主因子の解析2010
- Author(s)
  大江賢治、鶴野親是、倉光球、高浜洋一、浜口功、大隈和、前田明
- Organizer
  第12回日本RNA学会年会
- Place of Presentation
  東京、学術総合センター、一ツ橋記念講堂
- Year and Date
  2010-07-27
- Data Source
  KAKENHI-PROJECT-21591679
[Presentation] HMGA1a induces aberrant splicing of Estrogen Receptor α in MCF-7 breast cancer cells2010
- Author(s)
  Kenji Ohe, Toshiaki Utsumi, kila Mayeda
- Organizer
  14^<th> International Congress of Endocrinology
- Place of Presentation
  京都市、国立京都国際会館
- Year and Date
  2010-03-26
- Data Source
  KAKENHI-PROJECT-21591679
[Presentation] HMGA1a induces aberrant splicing of Estrogen Receptor α in MCF-7 breast cancer cells2010
- Author(s)
  Kenji Ohe, Toshiaki Utsumi, Akila Mayeda
- Organizer
  第6回国際ホルモン依存性癌シンポジウム
- Place of Presentation
  千葉、シエラトン・グランデ・トーキョーベイ・ホテル
- Data Source
  KAKENHI-PROJECT-21591679
[Presentation] 癌遺伝子産物HMGA1が、乳癌においてエストロゲン受容体αの異常スプライシングの誘導因子として機能しているかもしれない!2009
- Author(s)
  大江賢治, 内海俊明, 前田明
- Organizer
  第11回日本RNA学会年会
- Place of Presentation
  新潟市、朱鷺メッセ
- Data Source
  KAKENHI-PROJECT-21591679
[Presentation] エストロゲン受容体α46アイソフォーム発現に対するHMGA1aの影響2009
- Author(s)
  大江賢治
- Organizer
  第82回日本内分泌学会学術総会
- Place of Presentation
  前橋市
- Year and Date
  2009-04-22
- Data Source
  KAKENHI-PROJECT-21591679
[Presentation] エストロゲン受容体α46アイソフォーム発現に対するHMGA1aの影響2009
- Author(s)
  大江賢治
- Organizer
  第82回日本内分泌学会学術総会
- Place of Presentation
  前橋市、前橋商工会議所
- Data Source
  KAKENHI-PROJECT-21591679
[Presentation] 癌遺伝子産物HMGA1が、乳癌においてエストロゲン受容体αの異常スプライシングの誘導因子として機能しているかもしれない!2009
- Author(s)
  大江賢治、内海俊明、前田明
- Organizer
  第11回日本RNA学会年会
- Place of Presentation
  新潟市
- Year and Date
  2009-07-27
- Data Source
  KAKENHI-PROJECT-21591679
[Presentation] Oncogenic Product HMGA1a Might Function as Aberrant Splicing Inducer of Estrogen Receptor α in Breast Cancer2009
- Author(s)
  Kenji Ohe, Toshiaki Utsumi, Akila Mayeda
- Organizer
  2009 EUKARYOTIC mRNA PROCESSING meeting(Cold Spring Harbor Laboratory meeting)
- Place of Presentation
  ニューヨーク州、コールド・スプリング・ハーバー
- Year and Date
  2009-08-18
- Data Source
  KAKENHI-PROJECT-21591679
[Presentation] SF-1/Ad4BPを強制発現した骨髄・脂肪由来間葉系幹細胞のステロイド産生能の異同とレチノイン酸の影響2007
- Author(s)
  權藤重喜、岡部泰二郎、田中智子、森永秀孝、白水久男、大江賢治、野村政壽、名和田新、柳瀬敏彦、高柳涼一
- Organizer
  第80回日本内分泌学会学術総会
- Place of Presentation
  東京
- Year and Date
  2007-06-14
- Data Source
  KAKENHI-PROJECT-18591028
[Presentation] SF-1/Ad4BPはヒト骨髄由来間葉系幹細胞をステロイドホルモン産生細胞へ分化誘導する2007
- Author(s)
  田中智子、權藤重喜、岡部泰二郎、大江賢治、野村政壽、名和田新、柳瀬敏彦、高柳涼一
- Organizer
  第80回日本内分泌学会学術総会
- Place of Presentation
  東京
- Year and Date
  2007-06-14
- Data Source
  KAKENHI-PROJECT-18591028
[Presentation] 骨髄および脂肪由来間葉系幹細胞のステロイド産生細胞への分化誘導2006
- Author(s)
  田中智子、権藤重喜、岡部泰二郎、森永秀孝、大江賢治、野村政壽、名和田新、柳瀬敏彦、高柳涼一
- Organizer
  第43回日本臨床分子医学会
- Place of Presentation
  札幌
- Year and Date
  2006-07-20
- Data Source
  KAKENHI-PROJECT-18591028
[Presentation] SF-1/Ad4BP transforms mouse mesenchymal stem cells derived from both bone marrow and adipose tissue into steroidogenic cells2006
- Author(s)
  Gondo,S.,Tanaka,T.,Okabe,T.,Morinaga,H. ,Ohe,K.,Nomura,M.,Takayanagi,R.,Yanase, T.
- Organizer
  12^<th> International Congress on Hormonal Steroids and Hormones & Cancer
- Place of Presentation
  Athens
- Year and Date
  2006-09-13
- Data Source
  KAKENHI-PROJECT-18591028
[Presentation] SF-1/Ad4BP はヒト長期培養骨髄細胞およびマウス初代長期培養脂肪幹細胞をステロイドホルモン産生細胞に変化させる2006
- Author(s)
  權藤重喜、田中智子、岡部泰二郎、森永秀孝、大江賢治、野村政壽、名和田新、柳瀬敏彦、高柳涼一
- Organizer
  第79回日本内分泌学会学術総会
- Place of Presentation
  神戸
- Year and Date
  2006-05-19
- Data Source
  KAKENHI-PROJECT-18591028

1. NOMURA Masatoshi (30315080)

# of Collaborated Projects: 6 results

# of Collaborated Products: 14 results
2. OKABE Taijiro (40264030)

# of Collaborated Projects: 5 results

# of Collaborated Products: 13 results
3. YANASE Toshihiko (30239818)

# of Collaborated Projects: 4 results

# of Collaborated Products: 14 results
4. MAYEDA Akila (50212204)

# of Collaborated Projects: 3 results

# of Collaborated Products: 21 results
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Ohe Kenji 大江 賢治

OHE Kenji 大江 賢治

大江 賢治 オオエ ケンジ

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Developing a novel treatment of adrenocortical carcinoma by a CK2 inhibitorPrincipal Investigator

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Seeking a novel therapy for hereditary breast cancer by modulating alternative splicingPrincipal Investigator

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Exploring a novel therapy of hormone-resistant breast cancer by short RNAPrincipal Investigator

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Regulation of Estrogen Receptor Alpha through novel function of HMGA1a.-Towards a novel breast cancer therapy-Principal Investigator

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Ohe Kenji 大江賢治

OHE Kenji 大江賢治

大江賢治オオエケンジ

[Book] スプライシング　生体の科学　特集　細胞シグナル操作法　II.　機能からみたシグナル操作法2015

[Book] 選択的スプライシング・ネットワークを化合物で操作する　生体の科学　特集「細胞を化学で観察する・操作する」2015

[Book] BIO Clinica　BIOLOGY TOPICS 選択的スプライシングを標的とした低分子化合物の医薬品開発2014