Takeuchi Akihide 武内章英

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TAKEUCHI Akihide 武内章英

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Researcher Number	90436618
Other IDs	https://orcid.org/0000-0002-2781-0180
Affiliation (Current)	2026: 愛媛大学, 医学系研究科, 教授
Affiliation (based on the past Project Information) *help	2021 – 2026: 愛媛大学, 医学系研究科, 教授 2015 – 2020: 京都大学, 医学研究科, 准教授 2011 – 2015: 京都大学, 医学(系)研究科(研究院), 准教授 2014: 京都大学, 大学院医学研究科, 准教授 2011: 京都大学, 医学(系)研究科(研究院), 助教 2010: 京都大学, 医学研究科, 助教 2007 – 2008: Tokyo Medical and Dental University, 難治疾患研究所, 助教
Review Section/Research Field	Principal Investigator Basic Section 48010:Anatomy-related / Basic Section 46010:Neuroscience-general-related / Neuroscience in general / Neuroscience in general Except Principal Investigator General pharmacology / Basic Section 59040:Nutrition science and health science-related / Broad Section H / Chemical biology / Chemical biology / Applied genomics
Keywords	Principal Investigator RNA結合タンパク質 / Sfpq / 液-液相分離構造 / 高次遺伝子発現ネットワーク制御 / 神経超長鎖遺伝子 / 超長鎖遺伝子 / 神経科学 / 自閉症スペクトラム(ALS) / 自閉症スペクトラム (ALS) / エピゲノム制御 … More / クロマチン制御 / 液ー液相分離構造 / 高次遺伝子発現ネットワーク制御機構 / クロマチン制御因子 / 神経エピジェネティックス / 質量分析 / 免疫沈降 / 長鎖遺伝子発現制御 / 免疫沈降・質量分析 / 超長鎖遺伝子発現制御 / RNA修飾 / DNA修飾 / ヒストン修飾 / クロマチン・リモデリングファクター / 可視化 / FGFR3 / 発生・分化 / スプライシング / 発生、分化 / スプライス・サイト認識 / Fibroblast Growth Factor Receptor2 / スプライシング・レポーターマウス / スプライシング・レポーター / 組織特異的スプライシング制御 / 相互排他的スプライシング制御 / 選択的スプライシング制御 / (8)スプライス・サイト認識 / (7)RNA結合タンパク質 / (6)Fibroblast Growth Factor Receptor2 / (5)スプライシング・レポーターマウス / (4)スプライシング・レポーター / (3)組織特異的スプライシング制御 / (2)相互排他的スプライシング制御 / (1)選択的スプライシング制御 … More Except Principal Investigator スプライシング / RNA結合タンパク質 / iPS / CRISPR / 遺伝子発現制御 / 近接依存性標識 / 骨格筋代謝 / 骨格筋量 / RNAプロセシング / 液－液相分離 / RNA結合蚕白質 / SRタンパク / 病的液-液相分 / 転写 / RNA ポリメラーゼII / SRタンパク質 / 病的液-液相分離 / kibans / トランスクリプトーム / RNA病モデル / モデルトランスクリプトーム解析 / トランスクリプトーム解析 / RNA病 / スプライシング介入ルール / 遺伝子性疾患 / ポストゲノム創薬 / スプライシング制御 / 遺伝性疾患 / 創薬 / ハイスループット / 低分子化合物 / DYRK1A / 細胞 / ストレス / FTDP-17 / アルツハイマー / 神経変性疾患 / 急性ストレス / リン酸化酵素 / タウ / スクリーニング / 化合物 / アルツハイマー病 / タウオパチー / 発現パターン / 大脳皮質 / mRNA / 神経発生 / プロファイリング解析 / スプライシング調節因子 / エクソンアレイ / 大脳皮質形成 / mRNA前駆体 / 遺伝学 / 可視化 / Fox-1 / シス・エレメント / 線虫 / レポーター / 蛍光タンパク質 / 選択的スプライシング Less

Deciphering Gene Expression Regulatory Mechanisms Governing Skeletal Muscle Mass and Metabolism through Nuclear Condensates
- Principal Investigator
  
  細川元靖
- Project Period (FY)
  2026 – 2028
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  Ehime University
Deciphering the Mechanism of Multi-Dimensional Neuronal Gene Network Regulation and Its Association with Neurological DisordersPrincipal Investigator
- Principal Investigator
  
  武内章英
- Project Period (FY)
  2025 – 2028
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 48010:Anatomy-related
- Research Institution
  Ehime University
Deciphering the neural gene regulatory network system and its implication in neuronal diseasesPrincipal Investigator
- Principal Investigator
  
  武内章英
- Project Period (FY)
  2024 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 48010:Anatomy-related
- Research Institution
  Ehime University
Synthetic investigation of pathological phase separation of RNA-binding proteins
- Principal Investigator
  
  萩原正敏
- Project Period (FY)
  2021 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Review Section
  
  Broad Section H
- Research Institution
  Kyoto University
Deciphering neuroepigenetics that regulate the neural differentiationPrincipal Investigator
- Principal Investigator
  
  Takeuchi Akihide
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 46010:Neuroscience-general-related
- Research Institution
  Ehime University
  Kyoto University
トランスクリプトームの人為的操作による遺伝病の治療
- Principal Investigator
  
  萩原正敏
- Project Period (FY)
  2015
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  General pharmacology
- Research Institution
  Kyoto University
Therapeutic Drug Discovery and Elucidation of RNA Disease Pathogenesis by Use of CRISPR-Based Disease iPS Cells and Animal Models
- Principal Investigator
  
  Hagiwara Masatoshi
- Project Period (FY)
  2015 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Research Field
  
  Chemical biology
- Research Institution
  Kyoto University
Identification of a small molecule that induces autophagy-mediated degradation of TAU
- Principal Investigator
  
  HAGIWARA Masatoshi
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Chemical biology
- Research Institution
  Kyoto University
Analysis of neuronal stem cell-specific expression mechanism of Fgfr3 and its function on corticogenesisPrincipal Investigator
- Principal Investigator
  
  TAKEUCHI Akihide
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neuroscience in general
- Research Institution
  Kyoto University
Analyzing neuronal development through deciphering splicing code
- Principal Investigator
  
  HAGIWARA Masatoshi
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  General pharmacology
- Research Institution
  Kyoto University
  Tokyo Medical and Dental University
Decipher the mechanism to generate proteome diversity with area specificity in mammalian central nervous systemPrincipal Investigator
- Principal Investigator
  
  TAKEUCHI Akihide
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neuroscience in general
- Research Institution
  Tokyo Medical and Dental University
Elucidation of alternative splicing regulation mechanisms byutilizing in vivo visualization system.
- Principal Investigator
  
  KUROYANAGI Hidehito
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Applied genomics
- Research Institution
  Tokyo Medical and Dental University

[Book] セントラルドグマの新常識2022
- Author(s)
  田口　英樹、小林　武彦、稲田　利文（分担執筆：武内章英）
- Total Pages
  264
- Publisher
  羊土社
- ISBN
  4758104042
- Data Source
  KAKENHI-PROJECT-19K06907
[Journal Article] Profiling of pathogenic variants in Japanese patients with sarcoglycanopathy.2025
- Author(s)
  Shimazaki R, Saito Y, Awaya T, Minami N, Kurosawa R, Hosokawa M, Ohara H, Hayashi S, Takeuchi A, Hagiwara M, Hayashi Y, Noguchi S & Nishino I
- Journal Title
  
  Journal of Rare Diseases
  
  Volume: 20 Issue: 1 Pages: 1-15
- DOI
  10.1186/s13023-024-03521-2
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22KJ2023, KAKENHI-PROJECT-23K24059, KAKENHI-PROJECT-23K16771
[Journal Article] Administration of prosaposin-derived neurotrophic factor to neural tube defects facilitates regeneration and restores neurological functions2023
- Author(s)
  Khan Sakirul、Takeuchi Akihide、Nabeka Hiroaki、Khan Farzana、Shimokawa Tetsuya、Takanezawa Sota、Saitou Takashi、Imamura Takeshi、Tachibana Tetsuya、Nishizono Akira、Hamada Fumihiko、Matsuda Seiji
- Journal Title
  
  iScience
  
  Volume: 26 Issue: 4 Pages: 106277-106277
- DOI
  10.1016/j.isci.2023.106277
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K06907, KAKENHI-PROJECT-21K06736, KAKENHI-PROJECT-21K09324, KAKENHI-PROJECT-23K24059
[Journal Article] Antagonist of sphingosine 1-phosphate receptor 3 reduces cold injury of rat donor hearts for transplantation.2023
- Author(s)
  Eisho Kanemitsu, Xiangdong Zhao, Keiko Iwaisako, Asuka Inoue, Akihide Takeuchi, Shintaro Yagi, Hidetoshi Masumoto, Hiroaki Ohara, Motoyasu Hosokawa, Tomonari Awaya, Junken Aoki, Etsuro Hatano, Shinji Uemoto, Masatoshi Hagiwara
- Journal Title
  
  Translational research
  
  Volume: 255 Pages: 26-36
- DOI
  10.1016/j.trsl.2022.11.003
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K17509, KAKENHI-PROJECT-19K06907, KAKENHI-PROJECT-19K22656, KAKENHI-PROJECT-23K18310, KAKENHI-PROJECT-21H05042, KAKENHI-PROJECT-23K24059, KAKENHI-PROJECT-21H02985
[Journal Article] 神経幹細胞のグリア新生への運命決定を制御するRNA結合タンパク質Qkの発見2021
- Author(s)
  武内章英
- Journal Title
  
  愛媛医学
  
  Volume: 40(3) Pages: 121-127
- Data Source
  KAKENHI-PROJECT-19K06907
[Journal Article] Identification of Qk as a Glial Precursor Cell Marker that Governs the Fate Specification of Neural Stem Cells to a Glial Cell Lineage2020
- Author(s)
  Takeuchi Akihide、Takahashi Yuji、Iida Kei、Hosokawa Motoyasu、Irie Koichiro、Ito Mikako、Brown J.B.、Ohno Kinji、Nakashima Kinichi、Hagiwara Masatoshi
- Journal Title
  
  Stem Cell Reports
  
  Volume: 15 Issue: 4 Pages: 883-897
- DOI
  10.1016/j.stemcr.2020.08.010
- NAID
  120006888017
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K06907, KAKENHI-PROJECT-20K06925, KAKENHI-PROJECT-19K22802, KAKENHI-PROJECT-15H05721, KAKENHI-PROJECT-20H03561, KAKENHI-PROJECT-17K07094
[Journal Article] Multilateral Bioinformatics Analyses Reveal the Function-Oriented Target Specificities and Recognition of the RNA-Binding Protein SFPQ2020
- Author(s)
  Iida Kei、Hagiwara Masatoshi、Takeuchi Akihide
- Journal Title
  
  iScience
  
  Volume: 23 Issue: 7 Pages: 101325-101325
- DOI
  10.1016/j.isci.2020.101325
- NAID
  120006875263
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K06907, KAKENHI-PROJECT-15H05721
[Journal Article] Loss of RNA-binding protein Sfpq causes long-gene transcriptopathy in skeletal muscle and severe muscle mass reduction with metabolic myopathy.2019
- Author(s)
  Hosokawa M, Takeuchi A, Tanihata J, Iida K, Takeda S, Hagiwara M
- Journal Title
  
  iScience
  
  Volume: 13 Pages: 229-242
- DOI
  10.1016/j.isci.2019.02.023
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K08726, KAKENHI-PROJECT-15H05721
[Journal Article] Loss of Sfpq causes long-gene transcriptopathy in the brain.2018
- Author(s)
  Takeuchi A, Iida K, Tsubota T, Hosokawa M, Denawa M, Brown JB, Ninomiya K, Ito M, Kimura H, Abe T, Kiyonari H, Ohno K, and Hagiwara M
- Journal Title
  
  Cell Reports.
  
  Volume: 23 Issue: 5 Pages: 1326-1341
- NAID
  120006463742
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21249013
[Journal Article] Loss of Sfpq Causes Long-Gene Transcriptopathy in the Brain2018
- Author(s)
  Takeuchi Akihide、Iida Kei、Tsubota Toshiaki、Hosokawa Motoyasu、Denawa Masatsugu、Brown J.B.、Ninomiya Kensuke、Ito Mikako、Kimura Hiroshi、Abe Takaya、Kiyonari Hiroshi、Ohno Kinji、Hagiwara Masatoshi
- Journal Title
  
  Cell Reports
  
  Volume: 23 Issue: 5 Pages: 1326-1341
- DOI
  10.1016/j.celrep.2018.03.141
- NAID
  120006463742
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K07094, KAKENHI-PROJECT-15H05721
[Journal Article] Rectifier of aberrant mRNA splicing recovers tRNA modification in familial dysautonomia.2015
- Author(s)
  Yoshida M, Kataoka N, Miyauchi K, Ohe K, Iida K, Yoshida S, Nojima T, Okuno Y, Onogi H, Usui T, Takeuchi A, Hosoya T, Suzuki T, Hagiwara M.
- Journal Title
  
  Proc Natl Acad Sci U S A.
  
  Volume: 112（9） Issue: 9 Pages: 2764-2769
- DOI
  10.1073/pnas.1415525112
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24241076, KAKENHI-PROJECT-25620125, KAKENHI-PROJECT-26220205, KAKENHI-PROJECT-15K10050, KAKENHI-PLANNED-26113003, KAKENHI-PROJECT-15H05721, KAKENHI-PROJECT-21249013
[Journal Article] 可視化スプライシング・レポーターシステムで開く哺乳類の mRNA 制御の世界2012
- Author(s)
  武内章英、萩原正敏
- Journal Title
  
  細胞工学
  
  Volume: VOl.31 No.6
- NAID
  40019333323
- Data Source
  KAKENHI-PROJECT-21249013
[Journal Article] 可視化スプライシング・レポーターシステムで開く哺乳類のmRNA制御の世界2012
- Author(s)
  武内章英、萩原正敏
- Journal Title
  
  細胞工学
  
  Volume: 31
- NAID
  40019333323
- Data Source
  KAKENHI-PROJECT-21249013
[Journal Article] Special Review可視化スプライシング・レポーターシステムで開く2012
- Author(s)
  武内章英, 萩原正敏
- Journal Title
  
  哺乳類のmRNA制御の世界細胞工学
  
  Volume: Vol.31 No.6 Pages: 698-704
- Data Source
  KAKENHI-PROJECT-22500288
[Journal Article] Fgfr1 and the IIIc isoform of Fgfr2 play critical roles in the metanephric mesenchyme mediating early inductive events in kidney development2011
- Author(s)
  Sims-Lucas S, Cusack B, Baust J, Eswarakumar VP, Masatoshi H, Takeuchi A, Bates CM
- Journal Title
  
  Dev Dyn
  
  Volume: 240(1) Issue: 1 Pages: 240-9
- DOI
  10.1002/dvdy.22501
- Data Source
  KAKENHI-PROJECT-22500288
[Journal Article] Splicing reporter mice revealed the evolutionally conserved switching mechanism of tissue-specific alternative exon selection2010
- Author(s)
  Takeuchi A, Hosokawa M, Nojima T, Hagiwara M
- Journal Title
  
  PLoS One
  
  Volume: 5(6) Issue: 6 Pages: e10946-e10946
- DOI
  10.1371/journal.pone.0010946
- Data Source
  KAKENHI-PROJECT-22500288
[Journal Article] Splicing reportermice revealed the evolutionally conserved switching mechanism of tissue-specific alternative splicing.2010
- Author(s)
  Takeuchi A, Hosokawa M, Nojima T, Hagiwara M
- Journal Title
  
  PLOS One
  
  Volume: 5
- Data Source
  KAKENHI-PROJECT-21249013
[Journal Article] Splicing Reporter Mice Revealed the Evolutionally Conserved Switching Mechanism of Tissue-Specific Alternative Exon Selection2010
- Author(s)
  Akihide Takeuchi, Motoyasu Hosokawa, Takayuki Nojima, Masatoshi Hagiwara
- Journal Title
  
  PLoS One (accepted)
- Data Source
  KAKENHI-PROJECT-19500269
[Journal Article] Splicing reporter mice revealed the evolutionally conserved switching mechanism of tissue-specific alternative exon selection2010
- Author(s)
  Takeuchi A, Hosokawa M, Nojima T, Hagiwara M
- Journal Title
  
  PLoS One
  
  Volume: 3;5(6)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249013
[Patent] Transgenic reporter system that reveals expression profiles and regulation mechanisms of alternative splicing in mammalian organisms.2015
- Inventor(s)
  萩原正敏、武内彰英
- Industrial Property Rights Holder
  萩原正敏、武内彰英
- Industrial Property Rights Type
  特許
- Filing Date
  2015-04-01
- Acquisition Date
  2016-01-29
- Data Source
  KAKENHI-PROJECT-15H05721
[Patent] Transgenic reporter system that reveals expression profiles and regulation mechanisms of alternative splicing in mammalian organisms2013
- Inventor(s)
  Masatoshi Hagiwara, Akihide Takeuchi
- Industrial Property Rights Holder
  Kyoto university
- Acquisition Date
  2013-01-11
- Overseas
- Data Source
  KAKENHI-PROJECT-22500288
[Patent] 哺乳類生物における選択的スプライシングの発現プロファイルおよび制御機構を明らかにするトランスジェニックレポーターシステム2012
- Inventor(s)
  萩原正敏, 武内章英
- Industrial Property Rights Holder
  国立大学法人京都大学
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2012-554135
- Filing Date
  2012-11-30
- Overseas
- Data Source
  KAKENHI-PROJECT-22500288
[Patent] Transgenic reporter system that reveals expression profiles and regulation mechanisms of alternative splicing in mammalian organisms2012
- Inventor(s)
  Masatoshi Hagiwara, Akihide Takeuchi
- Industrial Property Rights Holder
  Kyoto university
- Acquisition Date
  2012-11-30
- Overseas
- Data Source
  KAKENHI-PROJECT-22500288
[Patent] Transgenic reporter system that reveals expression profile and regulation mechanisms of alternative splicing in mammalian organisms2011
- Inventor(s)
  萩原正敏、武内章英
- Industrial Property Rights Holder
  萩原正敏、武内章英
- Filing Date
  2011-05-31
- Acquisition Date
  2016-01-29
- Description
  9,273,364(US) 2576778(EP) 2012.11.29(US) 2013.1.1(EP) 2016.3.1(US) 2017.8.9(EP)
- Data Source
  KAKENHI-PROJECT-21249013
[Patent] Transgenic reporter system that reveals expression profile and regulation mechanisms of alternative splicing in mammalian organisms2011
- Inventor(s)
  萩原正敏、武内章英
- Industrial Property Rights Holder
  萩原正敏、武内章英
- Filing Date
  2011-05-31
- Description
  US.61/350,420 2010年6月1日(米国)
- Overseas
- Data Source
  KAKENHI-PROJECT-21249013
[Patent] Transgenic reporter system that reveals expression profiles and regulation mechanisms of alternative splicing in mammalian organisms2011
- Inventor(s)
  萩原正敏、武内章英
- Industrial Property Rights Holder
  萩原正敏、武内章英
- Filing Date
  2011-05-31
- Overseas
- Data Source
  KAKENHI-PROJECT-21249013
[Patent] Transgenic reporter system that reveals expression profiles and regulation mechanisms of alternative splicing in mammalian organisms2010
- Inventor(s)
  萩原正敏, 武内章英
- Industrial Property Rights Holder
  萩原正敏, 武内章英
- Filing Date
  2010
- Overseas
- Data Source
  KAKENHI-PROJECT-21249013
[Presentation] Profiling of pathogenic variants in Japanese patients with sarcoglycanopathy2024
- Author(s)
  Shimazaki R, Saito Y, Awaya T, Kurosawa R, Hosokawa M, Ohara H, Hayashi S, Takeuchi A, Hagiwara M, Hayashi Y.K,. Noguchi S, Nishino I
- Organizer
  The 29th Annual Congress of the World Muscle Society (WMS 2024)
- Data Source
  KAKENHI-PROJECT-23K24059
[Presentation] Identification of deep intronic pathogenic variants in autosomal recessive muscle disorders by in silico splicing prediction.2024
- Author(s)
  Shimazaki R, Saito Y, Awaya T, Minami N, Kurosawa R, Hosokawa M, Ohara H, Hayashi S, Takeuchi A, Hagiwara M, Hayashi Y.K,. Noguchi S, Nishino I
- Organizer
  The 29th Annual Congress of the World Muscle Society (WMS 2024)
- Data Source
  KAKENHI-PROJECT-23K24059
[Presentation] SFPQ maintains skeletal muscle mass through regulating aerobic metabolism2024
- Author(s)
  Hosokawa M, Iida K, Tanihata J, Takeda S, Hagiwara M, Takeuchi A
- Organizer
  Joint Conference of the 22nd Annual Meeting of the Asian Oceanian Myology Center and the 10th Annual Meeting of the Japan Muscle Society (AOMC-JMS 2024)
- Data Source
  KAKENHI-PROJECT-23K24059
[Presentation] SFPQ maintains skeletal muscle mass through regulating aerobic metabolism2024
- Author(s)
  Hosokawa M, Iida K, Tanihata J, Takeda S, Hagiwara M, Takeuchi A
- Organizer
  Joint Conference of the 22nd Annual Meeting of the Asian Oceanian Myology Center and the 10th Annual Meeting of the Japan Muscle Society (AOMC-JMS 2024)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H05042
[Presentation] RNA結合タンパク質依存性の高次遺伝子発現クロストーク制御機構の解明 Deciphering the RNA-binding protein dependent crosstalk in Multi-Dimensional gene regulation2023
- Author(s)
  武内章英、細川元靖、加門正義、今見考志、川上良介、今村健志
- Organizer
  第95回日本生化学会大会（シンポジウム発表「次世代RNAバイオロジーの展望」）
- Data Source
  KAKENHI-PROJECT-21H05042
[Presentation] Deciphering the RNA-binding protein dependent crosstalk in Multi-Dimensional gene regulation2023
- Author(s)
  Akihide Takeuchi, Motoyasu Hosokawa, Masayoshi Kamon, Koshi Imami
- Organizer
  第24回日本RNA学会年会
- Data Source
  KAKENHI-PROJECT-23K24059
[Presentation] 神経細胞におけるRNA結合タンパク質複合体による高次遺伝子発現制御機構と、その破綻により発症する神経発生異常、神経変性疾患、精神疾患の解明 RNA-binding protein complex regulate multi-dimensional gene expression machinery in neurons and their dysfunction causes neurological diseases2023
- Author(s)
  武内章英、細川元靖、加門正義、今見考志、川上良介、今村健志
- Organizer
  第46回日本分子生物学会（シンポジウム発表「神経機能におけるタンパク質/RNA恒常性の破綻～神経新生から神経病態まで～」）
- Data Source
  KAKENHI-PROJECT-23K24059
[Presentation] 神経細胞におけるRNA結合タンパク質複合体による高次遺伝子発現制御機構と、その破綻により発症する神経発生異常、神経変性疾患、精神疾患の解明 RNA-binding protein complex regulate multi-dimensional gene expression machinery in neurons and their dysfunction causes neurological diseases2023
- Author(s)
  武内章英、細川元靖、加門正義、今見考志、川上良介、今村健志
- Organizer
  第46回日本分子生物学会（シンポジウム発表「神経機能におけるタンパク質/RNA恒常性の破綻～神経新生から神経病態まで～」）
- Data Source
  KAKENHI-PROJECT-21H05042
[Presentation] RNA結合タンパク質依存性の高次遺伝子発現クロストーク制御機構の解明 Deciphering the RNA-binding protein dependent crosstalk in Multi-Dimensional gene regulation2023
- Author(s)
  武内章英、細川元靖、加門正義、今見考志、川上良介、今村健志
- Organizer
  第95回日本生化学会大会（シンポジウム発表「次世代RNAバイオロジーの展望」）
- Data Source
  KAKENHI-PROJECT-23K24059
[Presentation] 蛍光レポーターを用いた Alcam 遺伝子の選択的スプライシングの解析2022
- Author(s)
  福永拓, 梶田美穂子, 武内章英, 白壁恭子
- Organizer
  第68回日本生化学会近畿支部例会
- Data Source
  KAKENHI-PROJECT-19K06907
[Presentation] mRNAの制御から迫る、神経発生のメカニズム解析および神経・精神疾患の分子病態解明2022
- Author(s)
  武内章英
- Organizer
  京都大学医学研究支援センター 10周年記念セミナー(第3回)
- Invited
- Data Source
  KAKENHI-PROJECT-19K06907
[Presentation] Development of oligonucleotide drugs targeting phase separation for ALS/FTLD2022
- Author(s)
  Moniruzzaman Mohammad, Yusuke Fujioka, Akihide Takeuchi, Akio Masuda, Masahiro Neya, Shinsuke Ishigaki
- Organizer
  第41回日本認知症学会学術集会
- Data Source
  KAKENHI-PROJECT-23K24059
[Presentation] Development of oligonucleotide drugs targeting phase separation for ALS/FTLD2022
- Author(s)
  M. Mohammad, Y. Fujioka, A. Takeuchi, A. Masuda, M. Neya and S. Ishigaki
- Organizer
  第41回日本認知症学会学術集会
- Data Source
  KAKENHI-PROJECT-19K06907
[Presentation] 蛍光レポーターを用いた Alcam 遺伝子の選択的スプライシングの解析2022
- Author(s)
  福永拓, 梶田美穂子, 武内章英, 白壁恭子
- Organizer
  第68回日本生化学会近畿支部例会
- Data Source
  KAKENHI-PROJECT-23K24059
[Presentation] 骨格筋の超長鎖遺伝子を制御する高次遺伝子発現ネットワーク制御機構の解明2021
- Author(s)
  武内章英
- Organizer
  第7回日本筋学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-21H05042
[Presentation] 骨格筋の超長鎖遺伝子を制御する高次遺伝子発現ネットワーク制御機構の解明2021
- Author(s)
  武内章英、細川元靖
- Organizer
  第7回日本筋学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-19K06907
[Presentation] 神経発生を制御する "RNA world"2020
- Author(s)
  武内章英、細川元靖、飯田慶、萩原正敏
- Organizer
  京都大学メディカルイノベーション卓越大学院プログラム　医薬系研究交流サロン
- Data Source
  KAKENHI-PROJECT-19K06907
[Presentation] ワークショップ：脳・神経、筋細胞の分化・機能発現を制御するRNA結合タンパク質の多彩な生理機能解明のアプローチ2020
- Author(s)
  武内章英、飯田慶、細川元靖、萩原正敏
- Organizer
  第43回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-19K06907
[Presentation] 筋発生・代謝を制御する "RNA world"2020
- Author(s)
  細川元靖、武内章英、飯田慶、萩原正敏
- Organizer
  京都大学メディカルイノベーション卓越大学院プログラム　医薬系研究交流サロン
- Data Source
  KAKENHI-PROJECT-19K06907
[Presentation] What RNA binding proteins regulate in neural development and why it should be through mRNAs?2019
- Author(s)
  Akihide Takeuchi
- Organizer
  第3回RNA勉強会
- Data Source
  KAKENHI-PROJECT-15H05721
[Presentation] Sfpq-KOマウスをモデルとした骨格筋代謝-筋量制御ネットワークの解析2019
- Author(s)
  細川元靖、武内章英、谷端淳、飯田慶、武田伸一、萩原正敏
- Organizer
  第7回若手による骨格筋細胞研究会
- Data Source
  KAKENHI-PROJECT-19K06907
[Presentation] Sfpq-KOマウスをモデルとした骨格筋代謝-筋量制御ネットワークの解析2019
- Author(s)
  細川元靖、武内章英、谷端淳、飯田慶、武田伸一、萩原正敏
- Organizer
  日本筋学会第５回学術集会
- Data Source
  KAKENHI-PROJECT-19K06907
[Presentation] Dysfunction of RNA-binding protein Sfpq causes long-gene transcriptopathy in the brain.2019
- Author(s)
  Akihide Takeuchi
- Organizer
  Neuroscience 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05721
[Presentation] Sfpq-KOマウスをモデルとした骨格筋代謝-筋量制御ネットワークの解析2019
- Author(s)
  細川元靖、武内章英、谷端淳、飯田慶、武田伸一、萩原正敏
- Organizer
  第42回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-19K06907
[Presentation] What RNA Binding Proteins Regulate in Neural Development and Why it Should be through mRNAs ?2018
- Author(s)
  Akihide Takeuchi
- Organizer
  Cold Spring Harbor Asia Meeting RNA Biology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05721
[Presentation] RNA-binding protein Sfpq regulates skeletal muscle metabolism through promoting long-gene expression.2018
- Author(s)
  Akihide Takeuchi
- Organizer
  RNA 2018 23rd Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05721
[Presentation] Loss of Sfpq causes long-gene transcriptopathy in the brain2018
- Author(s)
  Akihide Takeuchi
- Organizer
  RNA 2018 23rd Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05721
[Presentation] Disruption of Sfpq causes selective downregulation of long genes and impaired skeletal muscle metabolism.2018
- Author(s)
  Akihide Takeuchi
- Organizer
  Cold Spring Harbor Asia Meeting RNA Biology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05721
[Presentation] 神経発生におけるRNA制御コードの解明と神経変性疾患・精神疾患との関連について Deciphering the RNA regulatory code by RNA-binding proteins in neural development and their associations with neurodegenerative and psychiatric diseases2018
- Author(s)
  武内章英
- Organizer
  第41回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-15H05721
[Presentation] 哺乳類の超長鎖遺伝子発現に必要である、RNA結合タンパク質によるmRNAプロセッシングと転写伸長活性化機構2015
- Author(s)
  武内章英、飯田慶、二宮賢介、出縄政嗣、坪田智明、伊藤美佳子、大野欽司、萩原正敏
- Organizer
  第17回日本RNA学会年会　口頭発表
- Place of Presentation
  ホテルライフォート札幌
- Year and Date
  2015-07-15
- Data Source
  KAKENHI-PROJECT-15H02505
[Presentation] 骨格筋における超長鎖遺伝子発現制御の分子機構の解明2015
- Author(s)
  細川元靖、武内章英、谷端淳、武田伸一、萩原正敏
- Organizer
  第17回日本RNA学会年会　ポスター発表
- Place of Presentation
  ホテルライフォート札幌
- Year and Date
  2015-07-15
- Data Source
  KAKENHI-PROJECT-15H02505
[Presentation] RNA制御の全容解明への挑戦2014
- Author(s)
  武内章英
- Organizer
  第1回バイオ・フロンティア・プラットフォームシンポジウム「京滋地域アカデミア連関における研究支援体制の整備」
- Place of Presentation
  京都
- Year and Date
  2014-12-01
- Data Source
  KAKENHI-PROJECT-21249013
[Presentation] RNA結合タンパク質は、mRNA processingを介して脳形成過程で何を制御しているのか?2013
- Author(s)
  武内章英, 伊藤美佳子, 大野欽司, 萩原正敏
- Organizer
  Neuro2013
- Place of Presentation
  国立京都国際会館
- Data Source
  KAKENHI-PROJECT-22500288
[Presentation] RNA結合タンパク質Sfpqは、神経発生過程において長いpre-mRNAの発現を制御する2013
- Author(s)
  武内章英、飯田　慶、二宮　賢介、伊藤　美佳子、大野　欽司、萩原　正敏
- Organizer
  第15回日本RNA学会年会
- Place of Presentation
  愛媛県　県民文化会館・ひめぎんホール
- Data Source
  KAKENHI-PROJECT-22500288
[Presentation] RNA Binding Protein Sfpq is required for the expression of neuron-specific long pre-mRNAs essential for brain development2013
- Author(s)
  Akihide Takeuchi, Kei Iida, Kensuke Ninomiya, Mikako Ito, Kinji Ohno, Masatoshi Hagiwara
- Organizer
  2013 CSHL Meeting on Eukaryotic mRNA Processing
- Place of Presentation
  Cold Spring Harbor Laboratory, NY, USA
- Data Source
  KAKENHI-PROJECT-22500288
[Presentation] RNA Binding Protein Sfpq is required for the expression of neuron-specific long pre-mRNAs essential for brain development2013
- Author(s)
  Akihide Takeuchi, Kei Iida, Kensuke Ninomiya, Mikako Ito, Kinji Ohno, Masatoshi Hagiwara
- Organizer
  Neuroscience 2013 San Diego
- Place of Presentation
  California, USA
- Data Source
  KAKENHI-PROJECT-22500288
[Presentation] RNA Binding Protein Sfpq is required for the expression of neuron-specific long pre-mRNAs essential for brain development2013
- Author(s)
  Akihide Takeuchi, Kei Iida, Kensuke Ninomiya, Mikako Ito, Kinji Ohno, Masatoshi Hagiwara
- Organizer
  2013 CSHL Meeting on Eukaryotic mRNA Processing Cold Spring Harbor Laboratory
- Place of Presentation
  NY, USA
- Data Source
  KAKENHI-PROJECT-22500288
[Presentation] RNA 結合タンパク質の機能解析から迫る、哺乳類中枢神経発生における RNA 制御の意義の解明2013
- Author(s)
  武内章英、飯田　慶、二宮賢介、伊藤美佳子、大野欽司、萩原正敏
- Organizer
  第118回日本解剖学会総会・全国学術集会
- Place of Presentation
  サンポートホール香川・かがわ国際会議場
- Data Source
  KAKENHI-PROJECT-22500288
[Presentation] RNA Binding Protein Sfpq is required for the expression of neuron-specific long pre-mRNAs essential for brain development.2013
- Author(s)
  Akihide Takeuchi, Kei Iida, Kensuke Ninomiya, Mikako Ito, Kinji Ohno, Masatoshi Hagiwara
- Organizer
  The 18th Annual Meeting of the RNA Society
- Place of Presentation
  Davos, Switzerland
- Data Source
  KAKENHI-PROJECT-22500288
[Presentation] RNA Binding Protein Sfpq is required for the expression of neuron-specific long pre-mRNAs essential for brain development.2013
- Author(s)
  Akihide Takeuchi, Kei Iida, Kensuke Ninomiya, Mikako Ito, Kinji Ohno, Masatoshi Hagiwara
- Organizer
  Neuroscience 2013
- Place of Presentation
  San Diego, California, USA
- Data Source
  KAKENHI-PROJECT-22500288
[Presentation] RNA結合タンパク質の機能解析から迫る、哺乳類中枢神経発生におけるRNA制御の意義の解明2013
- Author(s)
  武内章英, 伊藤美佳子, 大野欽司, 萩原正敏
- Organizer
  第118回日本解剖学会総会・全国学術集会
- Place of Presentation
  サンポートホール香川・かがわ国際会議場
- Data Source
  KAKENHI-PROJECT-22500288
[Presentation] RNA結合タンパク質Quakingの神経特異的ノックアウトマウスの解析2013
- Author(s)
  高橋裕司、和根崎圭子、武内章英、萩原　正敏
- Organizer
  2013 日本解剖学会近畿地方会
- Place of Presentation
  奈良先端大学大学院大学
- Data Source
  KAKENHI-PROJECT-22500288
[Presentation] What is the function of RNA-binding proteins in the process of brain format ion through regulating mRNA ?2013
- Author(s)
  武内章英、飯田　慶、二宮　賢介、伊藤　美佳子、大野　欽司、萩原　正敏
- Organizer
  Neuro2013
- Place of Presentation
  国立京都国際会館
- Data Source
  KAKENHI-PROJECT-22500288
[Presentation] RNA Binding Protein Sfpq is required for the expression of neuron-specific long pre-mRNAs essential for brain development2013
- Author(s)
  Akihide Takeuchi, Kei Iida, Kensuke Ninomiya, Mikako Ito, Kinji Ohno, Masatoshi Hagiwara
- Organizer
  The 18th Annual Meeting of the RNA Society Davos
- Place of Presentation
  Switzerland
- Data Source
  KAKENHI-PROJECT-22500288
[Presentation] 哺乳類の脳の発生過程でのｍＲＮＡ制御の網羅的解析2012
- Author(s)
  武内章英
- Organizer
  第117回日本解剖学会総会・全国学術集会
- Place of Presentation
  山梨県山梨大学甲府キャンパス
- Data Source
  KAKENHI-PROJECT-22500288
[Presentation] 哺乳類の脳の発生過程でのmRNA制御の網羅的解析2012
- Author(s)
  武内章英、伊藤美佳子、大野欽司、萩原正敏
- Organizer
  第117回日本解剖学会総会・全国学術集会
- Place of Presentation
  山梨大学甲府キャンパス
- Year and Date
  2012-03-26
- Data Source
  KAKENHI-PROJECT-22500288
[Presentation] 哺乳類の脳の発生過程でのmRNA制御の網羅的解析2012
- Author(s)
  武内章英, 伊藤美佳子, 大野欽司, 萩原正敏
- Organizer
  117回日本解剖学会総会
- Place of Presentation
  全国学術集会山梨大学甲府キャンパス
- Data Source
  KAKENHI-PROJECT-22500288
[Presentation] 哺乳類の脳の発生過程でのmRNA制御の網羅的解析2012
- Author(s)
  武内章英
- Organizer
  第117回日本解剖学会総会・全国学術集会
- Place of Presentation
  山梨山梨大学甲府キャンパス
- Year and Date
  2012-03-26
- Data Source
  KAKENHI-PROJECT-21249013
[Presentation] 哺乳類の脳の発生過程でのmRNA制御の網羅的解析Whole-genomic mRNA regulation analysis of neuronal development in mouse brain2010
- Author(s)
  武内章英, 渡辺要平, 伊藤美佳子, 大野欽司, 萩原正敏
- Organizer
  BMB2010 (第33回日本分子生物学会年会・第83回日本生化学会大会合同大会)
- Place of Presentation
  神戸ポートアイランド
- Data Source
  KAKENHI-PROJECT-22500288
[Presentation] スプライシング・レポーターシステムを用いた、哺乳類における相互排他的エクソン選択機構の解明2008
- Author(s)
  武内章英、細川元靖、萩原正敏
- Organizer
  RNAフロンティア・ミーティング2009
- Place of Presentation
  湘南国際村IPC生産性国際交流センター
- Data Source
  KAKENHI-PROJECT-19500269
[Presentation] Visualization of Alternative Splicing of Fibroblast Growth Factor Receptor 2 Revealed the Mutually Exclusive Regulatory Mechanism Cold Spring Harbor Laboratory Meeting2008
- Author(s)
  Akihide TAKEUCHI, Motoyasu Hosokawa, Masatoshi Hagiwara
- Organizer
  Eukaryotic mRNA Processing
- Place of Presentation
  Cold Spring Harbor, New York, U.S.A.
- Data Source
  KAKENHI-PROJECT-19500269
[Presentation] Fibroblast Growth Factor Receptorをモデルとした、哺乳類における相互排他的エクソン選択機構の解析2008
- Author(s)
  武内章英、細川元靖、萩原正敏
- Organizer
  第11回RNAミィーティング
- Place of Presentation
  新潟市朱鷺メッセ
- Data Source
  KAKENHI-PROJECT-19500269
[Presentation] Visualization of Alternative Splicing of Fibroblast Growth Factor Receptor 2 Revealed the Mutually Exclusive Regulatory Mechanism2008
- Author(s)
  Akihide TAKEUCHI、 Motoyasu Hosokawa、 Masatoshi Hagiwara
- Organizer
  Cold Spring Harbor Laboratory Meeting, Eukaryotic mRNA Processing
- Place of Presentation
  Cold Spring Harbor, New York
- Data Source
  KAKENHI-PROJECT-19500269
[Presentation] スプライシング・レポーターにより明らかになった、哺乳類における組織特異的な相互排他的エクソン選択機構(「王手飛車」制御メカニズム)2008
- Author(s)
  武内章英、細川元靖、萩原正敏
- Organizer
  第32回日本分子生物学会年会
- Place of Presentation
  パシフイコ横浜
- Data Source
  KAKENHI-PROJECT-19500269
[Presentation] Fibroblast Growth Factor Receptor をモデルとした、哺乳類における相互排他的エクソン選択機構の解析2008
- Author(s)
  武内章英, 細川元靖, 萩原正敏
- Organizer
  第11回 RNAミィーティング
- Place of Presentation
  新潟市朱鷺メッセ
- Data Source
  KAKENHI-PROJECT-19500269
[Presentation] スプライシング・レポーターにより明らかになった、哺乳類における組織特異的な相互排他的エクソン選択機構 (「王手飛車」制御メカニズム)2008
- Author(s)
  武内章英, 細川元靖, 萩原正敏
- Organizer
  第32回日本分子生物学会年会
- Place of Presentation
  パシフイコ横浜
- Data Source
  KAKENHI-PROJECT-19500269
[Presentation] スプライシング・レポーターシステムを用いた、哺乳類における相互排他的エクソン選択機構の解明2008
- Author(s)
  武内章英, 細川元靖, 萩原正敏
- Organizer
  RNAフロンティア・ミーティング2009
- Place of Presentation
  湘南国際村 IPC生産性国際交流センター
- Data Source
  KAKENHI-PROJECT-19500269

1. HAGIWARA Masatoshi (10208423)

# of Collaborated Projects: 8 results

# of Collaborated Products: 35 results
2. KUROYANAGI Hidehito (30323702)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
3. 飯田慶 (00387961)

# of Collaborated Projects: 3 results

# of Collaborated Products: 9 results
4. NINOMIYA Kensuke (00437279)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
5. HOSOYA Takamitsu (60273124)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
6. 大江賢治 (30419527)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. 奥野友紀子 (00372524)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. 粟屋智就 (20589593)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
9. 網代将彦 (60761864)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
10. OONO Kinji (80397455)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
11. KATAOKA Naoyuki (60346062)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
12. 鶴山竜昭 (00303842)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 吉澤拓也 (50779056)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 細川元靖 (60812683)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
15. TANIHATA Jun

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. MIKAKO Ito

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
17. 武田伸一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Takeuchi Akihide 武内 章英

TAKEUCHI Akihide 武内 章英

Research Projects

Research Products

Co-Researchers

Deciphering Gene Expression Regulatory Mechanisms Governing Skeletal Muscle Mass and Metabolism through Nuclear Condensates

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Deciphering the Mechanism of Multi-Dimensional Neuronal Gene Network Regulation and Its Association with Neurological DisordersPrincipal Investigator

Principal Investigator

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Review Section

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Deciphering the neural gene regulatory network system and its implication in neuronal diseasesPrincipal Investigator

Principal Investigator

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Review Section

Research Institution

Synthetic investigation of pathological phase separation of RNA-binding proteins

Principal Investigator

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Review Section

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Deciphering neuroepigenetics that regulate the neural differentiationPrincipal Investigator

Principal Investigator

Project Period (FY)

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トランスクリプトームの人為的操作による遺伝病の治療

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Therapeutic Drug Discovery and Elucidation of RNA Disease Pathogenesis by Use of CRISPR-Based Disease iPS Cells and Animal Models

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Identification of a small molecule that induces autophagy-mediated degradation of TAU

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Analysis of neuronal stem cell-specific expression mechanism of Fgfr3 and its function on corticogenesisPrincipal Investigator

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Analyzing neuronal development through deciphering splicing code

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Decipher the mechanism to generate proteome diversity with area specificity in mammalian central nervous systemPrincipal Investigator

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Elucidation of alternative splicing regulation mechanisms byutilizing in vivo visualization system.

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[Book] セントラルドグマの新常識2022

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Takeuchi Akihide 武内章英

TAKEUCHI Akihide 武内章英