Koizumi Naoya 小泉直也

… Alternative Names

KOIZUMI Naoya 小泉直也

Less

Researcher Number	80433845
External Links
Affiliation (Current)	2025: 昭和薬科大学, 薬学部, 准教授
Affiliation (based on the past Project Information) *help	2018 – 2019: 昭和薬科大学, 薬学部, 准教授 2013 – 2017: 昭和薬科大学, 薬学部, 講師 2006 – 2012: Showa Pharmaceutical University, Research Associate, 薬学部, 助教 2007: 昭和薬科大学, 薬学部, 助手
Review Section/Research Field	Principal Investigator Medical pharmacy / Biological pharmacy Except Principal Investigator Medical pharmacy
Keywords	Principal Investigator 薬学 / ターゲティング / がん / 医療薬剤学 / 遺伝子治療 / 再生医療 / バイオテクノロジー / DDS / がん治療 / ドラックデリバリーシステム … More / タンパクデリバリー / 組織深部 / ＤＤＳ / タンパク質医薬品 / 粘膜ワクチン / 血管内皮細胞 / RNAi / 癌遺伝子治療 / ドラックデリバリー / 遺伝子 … More Except Principal Investigator タイトジャンクション / ナノ粒子 / ワクチン / 生体膜透過バリアー機能 / 生理活性 / 薬理学 / 生体機能利用 / 皮膚 / レシチン逆ひも状ミセル / 経皮 / pharmacology / trophoblast cell / transgene expression / gene delivery system / RNA interference / drug permeation / placental barrier / 薬物透過機構 / 遺伝子 / トロホブラスト細胞 / 遺伝子発現 / 遺伝子導入 / RNA干渉 / 薬物透過 / 胎盤関門 / 生体膜透過制御 / 吸収促進法 / バイオ医薬品DDSの基礎研究 / 高分子薬物透過促進 / 生体膜透過制御機構 / 経皮投与 / 毛包 / 皮膚適用 / 薬剤反応性 / マイクロアレイ解析 / 遺伝子解析 / 消化管上皮細胞層 / 生体膜バリアー機構 / 薬物透過制御法 / 生理活学 / 生理学 / 薬学 / 遺伝子導入用アデノウイルスベクター / 薬物吸収促進作用 / 生体膜透過促進物質 / タイトジャンクション構成分子 / 生体膜透過性 Less

development of a therapeutic carrier protein for gene therapyPrincipal Investigator
- Principal Investigator
  
  KOIZUMI Naoya
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  Showa Pharmaceutical University
Development of nano-composite particle for transdermal vaccination system
- Principal Investigator
  
  FUJII Makiko
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  Nihon University
Strategic approach based on molecular mechanism for modulation of barrier function of tight junction to enhance delivery of new biopharmaceuticals
- Principal Investigator
  
  WATANABE Yoshiteru
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  Showa Pharmaceutical University
The development of protein delivery system through the cell membranePrincipal Investigator
- Principal Investigator
  
  KOIZUMI Naoya
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Medical pharmacy
- Research Institution
  Showa Pharmaceutical University
Development of dermal vaccine system targeting hair follicle with nanoparticle
- Principal Investigator
  
  FUJII Makiko
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  Showa Pharmaceutical University
Basic Study of orally-delivered vaccine development using a new innate immunity inducerPrincipal Investigator
- Principal Investigator
  
  KOIZUMI Naoya
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Medical pharmacy
- Research Institution
  Showa Pharmaceutical University
Studies of barrier function of tight junction in epithelial celllayers and strategic development of novel methods for drug permeation enhancement in cells
- Principal Investigator
  
  WATANABE Yoshiteru
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  Showa Pharmaceutical University
Development of tissue specific siRNA expression system to vascular endothelial cells in cancerPrincipal Investigator
- Principal Investigator
  
  KOIZUMI Naoya
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Medical pharmacy
- Research Institution
  Showa Pharmaceutical University
A Novel Strategy for Enhancement of Permeation and Absorption of Drugs by Modulation of Proteins Constructed Barrier Function in Biomembrane
- Principal Investigator
  
  WATANABE Yoshiteru
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  Showa Pharmaceutical University
Development of fiber modified adenovirus vectorPrincipal Investigator
- Principal Investigator
  
  KOIZUMI Naoya
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Medical pharmacy
- Research Institution
  Showa Pharmaceutical University
細胞内動態を制御したアデノウイルスベクターの開発Principal Investigator
- Principal Investigator
  
  小泉直也
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Young Scientists (Start-up)
- Research Field
  
  Biological pharmacy
- Research Institution
  Showa Pharmaceutical University
Studies on Drug Permeation in Placental Barrier by RNA Interference
- Principal Investigator
  
  WATANABE Yoshiteru
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  Showa Pharmaceutical University

All 2019 2018 2017 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 Other

All Journal Article Presentation

[Journal Article] Efficient Adenovirus Gene Transter Methods in Human Cononic Caco-2 Epithelial Cells Using Capric Acid2015
- Author(s)
  Koizumi N, Yamagishi Y, Hirai T, Fujii M, Mizuguchi H, Watanabe Y.
- Journal Title
  
  Biol. Pharm. Bull.
  
  Volume: 38 Pages: 1240-1244
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25460222
[Journal Article] Sec61β Regulates Barrier Functions of Tight Junction through Expression of Claudin-4 in Madin-Darby Canine Kidney Cells2014
- Author(s)
  Washiyama M, Koizumi N, Fujii M, Watanabe Y.
- Journal Title
  
  Biol. Pharm. Bull.
  
  Volume: 37
- NAID
  130004147341
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460222
[Journal Article] Sec61β Regulates Barrier Function of Tight Junction through Expression of Claudin-4 in Madin-Darby Canine Kidney Cells2014
- Author(s)
  Washiyama M, Koizumi N, Fujii, M, Watanabe Y.
- Journal Title
  
  Biol. Pharm. Bull.
  
  Volume: 37 Pages: 979-986
- NAID
  130004147341
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25460222
[Journal Article] Percolation Analysis in Electrical Conductivity of Madin-Darby Canine Kidney and Caco-2 Cells by Permeation-Enhancing Agents2013
- Author(s)
  Washiyama M, Koizumi N, Fujii M, Kondoh M, Yagi K, Watanabe Y.
- Journal Title
  
  Biol. Pharm. Bull.
  
  Volume: 36 Pages: 384-389
- NAID
  130003382079
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460222
[Journal Article] Effect of application method on skin permeation of carboxyfluorescein incorporated in liposome2010
- Author(s)
  Y. Shimoyama, M. Fujii, Y. Kanda, A. Mizoguchi, H. Oda, N. Koizumi, Y. Watanabe
- Journal Title
  
  Chem. Pharm. Bull
  
  Volume: 58 Pages: 429-431
- URL
  https://www.jstage.jst.go.jp/article/cpb/58/3/58_3_429/_pdf
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590178
[Journal Article] A highly efficient short hairpin RNA potently down-regulates CCR5 expression in systemic lymphoid organs in the hu-BLT mouse model.2010
- Author(s)
  Shimizu S, Hong P, Arumugam B, Pokomo L, Boyer J, Koizumi N, Kittipongdaja P, Chen A, Bristol G, Galic Z, Zack JA, Yang O, Chen IS, Lee B, An DS.
- Journal Title
  
  Blood 8
  
  Pages: 1534-1544
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790161
[Journal Article] A highly efficient short hairpin RNA potently down-regulates CCR5 expression in systemic lymphoid organs in the hu-BLT mouse model.2010
- Author(s)
  Shimizu S, Hong P, Arumugam B, Pokomo L, Boyer J, Koizumi N, Kittipongdaja P, Chen A, Bristol G, Galic Z, Zack JA, Yang O, Chen IS, Lee B, AnDS.
- Journal Title
  
  Blood
  
  Volume: 8 Pages: 1534-1544
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790161
[Journal Article] The modification of the pIX or hexon based on fiberless Ad vectors is not effective for the development of targeted Ad vectors2008
- Author(s)
  Kurachi S., Koizumi N., Tashiro K., Sakurai H., Sakurai F., Kawabata K., Nakagawa S., Mizuguchi H
- Journal Title
  
  J. Control. Release. 1
  
  Pages: 88-95
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790135
[Journal Article] Modification of pIX or hexon based on fiberless Ad vectors is not effective for targeted Ad vectors.2008
- Author(s)
  Kurachi, S・Koizumi, N, et. al.
- Journal Title
  
  J Control Release. 1
  
  Pages: 88-95
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790135
[Journal Article] Domain Mapping of A Claudin-4 Modulator, the C-terminal region of C-terminal Fragment of Clostridium perfringens Enterotoxin, by Site-directed Mutagenesis2008
- Author(s)
  Azusa Takahashi, Eriko Komiya, Hideki Kakutani, Takeshi Yoshida, Makiko Fujii, Yasuhiko Horiguchi, Hiroyuki Mizuguchi, Yasuo Tsutsumi, Shin-ichi Tsunoda, Naoya Koizumi, Katsuhiro Isoda, Kiyohito Yagi, Yoshiteru Watanabe and Masuo Kondoh
- Journal Title
  
  Biochem. Pharmacol 75
  
  Pages: 1639-1648
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590159
[Journal Article] Role of MyD88 and TLR9 in the innate immune response elicited by serotype 5 adenoviral vectors.2007
- Author(s)
  Yamaguchi, T・Kawabata, K・Koizumi, N, et. al.
- Journal Title
  
  Hum Gene Ther. 8
  
  Pages: 753-762
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790135
[Journal Article] Role of MyD88 and TLR9 in the Innate Immune Response Elicited by Serotype 5 Adenovirus Vectors.2007
- Author(s)
  Yamaguchi T., Kawabata K., Koizumi N., Sakurai F., Nakashima K., Sakurai H., Sasaki T., Okada N, Yamanishi K., Mizuguchi H
- Journal Title
  
  Hum. Gene Ther. 18
  
  Pages: 753-762
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790135
[Journal Article] Efficient Gene Transfer into Differentiated Human Trophoblast Cells with Adenovirus Vector Containing RGD motif in the Fiber Protein2006
- Author(s)
  Koizumi N., Watanabe T., et al.
- Journal Title
  
  Bio.Pharm.Bull. 29(In press)
- NAID
  110005602289
- Data Source
  KAKENHI-PROJECT-17590136
[Journal Article] Efficient gene transfer into differentiated human trophoblast cells with adenovirus vector containing RGD motif in the fiber protein.2006
- Author(s)
  Koizumi, N., Mizuguchi, H., Kondoh, M., Watanabe, Y, et al.
- Journal Title
  
  Biol. Pharm. Bull. 29
  
  Pages: 1297-1299
- NAID
  110005602289
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590136
[Journal Article] Efficient Gene Transfer into Differentiated Human Trophoblast Cells With Adenovirus Vector Conthining RGD Motif in the Fiber Protein.2006
- Author(s)
  Koizumi N, Mizuguchi H, Watanabe Y., et al.
- Journal Title
  
  Biol. Pharm. Bull. 29
  
  Pages: 1297-1299
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590136
[Presentation] 細胞間移行能を持つキャリアタンパク質の有用性評価2019
- Author(s)
  狩野順平、鈴木悠りか、小林舞、小泉直也、平井孝昌、野村鉄也、水口裕之、宇都口直樹
- Organizer
  日本薬学会139年会
- Data Source
  KAKENHI-PROJECT-17K08464
[Presentation] knobタンパク質のキャリア機能への抗knob抗体の影響2019
- Author(s)
  鈴木悠りか、狩野順平、小林舞、小泉直也、平井孝昌、野村鉄也、宇都口直樹
- Organizer
  第３５回日本DDS学術集会
- Data Source
  KAKENHI-PROJECT-17K08464
[Presentation] 細胞間移行能を持つアデノウイルス由来タンパク質の細胞局在評価2019
- Author(s)
  碓井美穂、狩野順平、梅澤麻衣、小泉直也、平井孝昌、野村鉄也、宇都口直樹
- Organizer
  第３５回日本DDS学術集会
- Data Source
  KAKENHI-PROJECT-17K08464
[Presentation] CD46を標的とした細胞膜表面移行性キャリアタンパク質の創生2018
- Author(s)
  秋山裕美、小泉直也、築谷美沙、平井孝昌、野村鉄也、水口裕之、宇都口直樹
- Organizer
  第34回日本DDS学会学術集会
- Data Source
  KAKENHI-PROJECT-17K08464
[Presentation] アデノウイルスノブタンパク質との融合によるタンパク質機能の維持2018
- Author(s)
  小林佳恵、小泉直也、小林舞、平井孝昌、野村鉄也、水口裕之、宇都口直樹
- Organizer
  第34回日本DDS学会学術集会
- Data Source
  KAKENHI-PROJECT-17K08464
[Presentation] IL-10とノブタンパク質の融合タンパク質を利用した免疫細胞機能制御2018
- Author(s)
  築谷美沙、小泉直也、秋山裕美、平井孝昌、野村鉄也、水口裕之、宇都口直樹
- Organizer
  第34回日本DDS学会学術集会
- Data Source
  KAKENHI-PROJECT-17K08464
[Presentation] アデノウイルスノブタンパク質の局在およびCARとの相互作用解析2017
- Author(s)
  大木佑華、小泉直也、佐藤孝太、池田祥子、平井孝昌、野村鉄也、水口裕之、宇都口直樹
- Organizer
  第33回日本DDS学会
- Data Source
  KAKENHI-PROJECT-17K08464
[Presentation] アデノウイルスノブタンパク質を利用したがん遺伝子治療メカニズムの解析2017
- Author(s)
  佐々木有彩1、小泉直也、狩野順平、平井孝昌、野村鉄也、水口裕之、宇都口直樹
- Organizer
  第33回日本DDS学会
- Data Source
  KAKENHI-PROJECT-17K08464
[Presentation] アデノウイルスノブタンパク質の細胞表面移行機構の解析2017
- Author(s)
  佐藤孝太、小泉直也、大木佑華、吉田春菜、平井孝昌、野村鉄也、水口裕之、宇都口直樹
- Organizer
  第61回日本薬学会関東支部大会
- Data Source
  KAKENHI-PROJECT-17K08464
[Presentation] 上皮細胞におけるアデノウイルスノブタンパク質の移行挙動解析2017
- Author(s)
  畠山紗也1、小泉直也1、大木佑華、池田祥子、平井孝昌、野村鉄也、水口裕之、宇都口直樹
- Organizer
  第33回日本DDS学会
- Data Source
  KAKENHI-PROJECT-17K08464
[Presentation] 共焦点レーザー顕微鏡による新規皮膚移行性評価法の構築2015
- Author(s)
  鈴木桃子，藤井まき子，飯野隼人，小泉直也，渡辺善照
- Organizer
  第59回日本薬学会関東支部大会
- Place of Presentation
  日本大学薬学部（千葉・船橋）
- Year and Date
  2015-09-12
- Data Source
  KAKENHI-PROJECT-15K08108
[Presentation] DDSキャリアとしてのアデノウイルスknobタンパク質の安定性評価2015
- Author(s)
  蛭間仁美, 小泉直也, 鈴木結衣, 渡邉愛音, 藤井まき子, 渡辺善照
- Organizer
  第59回日本薬学会関東支部大会
- Place of Presentation
  日本大学薬学部　（船橋市）
- Year and Date
  2015-09-12
- Data Source
  KAKENHI-PROJECT-25460222
[Presentation] 上皮細胞のCoxsackievirus and Adenovirus Receptor (CAR) を標的としたタンパク送達システムの検討2015
- Author(s)
  大久保莉菜、小泉直也、畠山紗也、藤井まき子、角田慎一、渡辺善照
- Organizer
  第59回日本薬学会関東支部大会
- Place of Presentation
  日本大学薬学部　（船橋市）
- Year and Date
  2015-09-12
- Data Source
  KAKENHI-PROJECT-25460222
[Presentation] 皮膚感作における酸化チタンナノ粒子の影響2015
- Author(s)
  佐藤あんな，藤井まき子，栗岡　瑶，増田年紀，伊達友哉，小泉直也，渡辺善照
- Organizer
  第59回日本薬学会関東支部大会
- Place of Presentation
  日本大学薬学部（千葉・船橋）
- Year and Date
  2015-09-12
- Data Source
  KAKENHI-PROJECT-15K08108
[Presentation] 5型アデノウイルスベクターの遺伝子導入におけるHSP90の影響2015
- Author(s)
  井上祥一, 小泉直也, 平井孝昌, 水口裕之, 藤井まき子, 渡辺善照
- Organizer
  第59回日本薬学会関東支部大会
- Place of Presentation
  日本大学薬学部　（船橋市）
- Year and Date
  2015-09-12
- Data Source
  KAKENHI-PROJECT-25460222
[Presentation] Ｓｅｃ61βによるタイトジャンクション開口・形成速度亢進のメカニズム2014
- Author(s)
  鷲山真紀子、小泉直也、藤井まき子、渡辺善照
- Organizer
  日本薬学会第134年会
- Place of Presentation
  熊本市総合体育館　（熊本市）
- Data Source
  KAKENHI-PROJECT-25460222
[Presentation] 微粒子酸化チタンが水溶性高分子の皮膚移行に及ぼす影響2014
- Author(s)
  伊達友哉，藤井まき子，増田年紀，佐藤あんな，小泉直也，渡辺善照
- Organizer
  第58回日本薬学会関東支部大会
- Place of Presentation
  昭和薬科大学（東京）
- Year and Date
  2014-10-04
- Data Source
  KAKENHI-PROJECT-24590212
[Presentation] Effect of Sec61β gene on the tight junction barrier function in MDCK cells2013
- Author(s)
  Washiyama M, Koizumi N, Fujii M, Watanabe Y.
- Organizer
  40th Controlled Release Society Annual Meeting
- Place of Presentation
  Hawaii Convention Center (Hawaii, USA）
- Data Source
  KAKENHI-PROJECT-25460222
[Presentation] Role of Sec61β gene, a subunit of translocon, on barrier function of tight junction in epithelial cells2013
- Author(s)
  Watanabe Y, Washiyama M, Koizumi N, Fujii M.
- Organizer
  Asian Federation for Pharmaceutical Sciences 2013
- Place of Presentation
  Ramada Plaza Jeju Hotel (Jeju, Korea）
- Data Source
  KAKENHI-PROJECT-25460222
[Presentation] 35 型アデノウイルスベクターの感染に及ぼす shaft領域の関与2013
- Author(s)
  平井孝昌、小泉直也、藤井まき子、櫻井文教、水口裕之、渡辺善照
- Organizer
  日本薬学会第133 年会
- Place of Presentation
  神奈川県 (パシフィコ横浜)
- Year and Date
  2013-03-28
- Data Source
  KAKENHI-PROJECT-23659086
[Presentation] 細胞膜透過促進能を持つアデノウイルス由来 shaft タンパク質の機能解析(3):細胞結合因子の評価2012
- Author(s)
  持田理菜、小泉直也、平井孝昌、野中美和、藤井まき子、水口裕之、渡辺善照
- Organizer
  第28回日本DDS 学会学術集会
- Place of Presentation
  北海道 (札幌コンベンションセンター)
- Year and Date
  2012-07-05
- Data Source
  KAKENHI-PROJECT-23659086
[Presentation] MDCK細胞におけるタイトジャンクション機能へのSec61b遺伝子の関与2012
- Author(s)
  鷲山真紀子、小泉直也、佐々木杏沙、松本有未、藤井まき子、近藤昌夫、八木清仁、渡辺善照
- Organizer
  日本薬学会第132年会
- Place of Presentation
  北海道大学(北海道)
- Year and Date
  2012-03-30
- Data Source
  KAKENHI-PROJECT-21590178
[Presentation] 細胞膜透過促進能を持つアデノウイルス由来 shaft タンパク質の機能解析 (1):機能ドメインの評価2012
- Author(s)
  野中美和、小泉直也、平間奈苗、平井孝昌、持田理菜、藤井まき子、水口裕之、渡辺善照
- Organizer
  第28回日本 DDS 学会学術集会
- Place of Presentation
  北海道 (札幌コンベンションセンター)
- Year and Date
  2012-07-05
- Data Source
  KAKENHI-PROJECT-23659086
[Presentation] 細胞膜透過促進能を持つアデノウイルス由来shaftタンパク質の機能解析 (2)：免疫誘導能の評価2012
- Author(s)
  平井孝昌、小泉直也、酒井宏、野中美和、持田理菜、藤井まき子、水口裕之、渡辺善照
- Organizer
  第28回日本DDS学会学術集会
- Place of Presentation
  札幌コンベンションセンター（札幌市）
- Data Source
  KAKENHI-PROJECT-23659086
[Presentation] 細胞膜透過促進能を持つアデノウィルス由来shaftタンパク質の機能解析 (3) ：細胞結合因子の評価2012
- Author(s)
  持田理菜、小泉直也、平井孝昌、野中美和、藤井まき子、水口裕之、渡辺善照
- Organizer
  第28回日本DDS学会学術集会
- Place of Presentation
  札幌コンベンションセンター（札幌市）
- Data Source
  KAKENHI-PROJECT-23659086
[Presentation] 細胞膜透過促進能を持つアデノウイルス由来 shaft タンパク質の機能解析 (2)2012
- Author(s)
  平井孝昌、小泉直也、酒井宏、野中美和、持田理菜、藤井まき子、水口裕之、渡辺善照
- Organizer
  免疫誘導能の評価、第28回日本 DDS 学会学術集会
- Place of Presentation
  北海道(札幌コンベンションセンター)
- Year and Date
  2012-07-05
- Data Source
  KAKENHI-PROJECT-23659086
[Presentation] 細胞膜透過促進能を持つアデノウイルスshaftタンパク質の機能解析（１）：機能ドメインの評価2012
- Author(s)
  野中美和、小泉直也、平間奈苗、平井孝昌、持田理菜、藤井まき子、水口裕之、渡辺善照
- Organizer
  第28回日本DDS学会学術集会
- Place of Presentation
  札幌コンベンションセンター（札幌市）
- Data Source
  KAKENHI-PROJECT-23659086
[Presentation] タイトジャンクションバリアー機能に関与する遺伝子の解析2011
- Author(s)
  鷲山真紀子、小泉直也、苅込亜美、佐々木杏沙、松本有未、藤井まき子、近藤昌夫、八木清仁、渡辺善照
- Organizer
  第55回日本薬学会関東支部大会
- Place of Presentation
  東邦大学習志野キャンパス(千葉県)
- Year and Date
  2011-10-08
- Data Source
  KAKENHI-PROJECT-21590178
[Presentation] Caco-2細胞におけるタイトジャンクション開閉時での遺伝子発現変動の解析2011
- Author(s)
  苅込亜美、小泉直也、佐々木杏沙、藤井まき子、近藤昌夫、八木清仁、渡辺善照
- Organizer
  日本薬学会第131年会
- Place of Presentation
  誌上発表
- Year and Date
  2011-03-05
- Data Source
  KAKENHI-PROJECT-21590178
[Presentation] Caco-2細胞におけるタイトジャンクション開閉時での遺伝子発現変動の解析2011
- Author(s)
  苅込亜美、小泉直也、佐々木杏沙、藤井まき子、近藤昌夫、八木清仁、渡辺善照
- Organizer
  日本薬学会第131年会
- Place of Presentation
  要旨集上で発表
- Year and Date
  2011-03-05
- Data Source
  KAKENHI-PROJECT-21590178
[Presentation] アデノウイルスベクターの遺伝子導入に及ぼすfiber-shaftの役割2011
- Author(s)
  小泉直也、平井孝昌、藤井まき子、水口裕之、渡辺善照
- Organizer
  第27回日本DDS学会
- Place of Presentation
  東京大学本郷キャンパス(東京都)
- Year and Date
  2011-06-10
- Data Source
  KAKENHI-PROJECT-21590178
[Presentation] アデノウイルスベクターの遺伝子導入に及ぼす fiber-shaftの役割2011
- Author(s)
  小泉直也、平井孝昌、藤井まき子、水口裕之、渡辺善照
- Organizer
  第27回日本 DDS 学会学術集会
- Place of Presentation
  東京都 (東京大学本郷キャンパス)
- Year and Date
  2011-06-10
- Data Source
  KAKENHI-PROJECT-23659086
[Presentation] HIVイメージングシステムの開発2010
- Author(s)
  小泉直也、Suree Tom、清水佐紀、渡辺善照、安東星
- Organizer
  第26回日本DDS学会
- Place of Presentation
  大阪府大阪市大阪国際交流センター
- Year and Date
  2010-06-18
- Data Source
  KAKENHI-PROJECT-21790161
[Presentation] アデノウイルス由来Shaft質による物質取り込み機構の解明2010
- Author(s)
  山岸喜彰、酒井宏、小泉直也、藤井まき子、水口裕之、渡辺善照
- Organizer
  第26回日本DDS学会
- Place of Presentation
  大阪国際交流センター(大阪市)
- Year and Date
  2010-06-17
- Data Source
  KAKENHI-PROJECT-21590178
[Presentation] 細胞内への高分子薬物輸送方法の構築を目的としたアデノウイルスカプシドタンパク質の解明2010
- Author(s)
  山岸喜彰、小泉直也、水口裕之、藤井まき子、渡辺善照
- Organizer
  日本薬学会第130年会
- Place of Presentation
  岡山コンベンションセンター(岡山市)
- Year and Date
  2010-03-28
- Data Source
  KAKENHI-PROJECT-21590178
[Presentation] HIVイメージングシステムの開発2010
- Author(s)
  小泉直也、Suree Tom、清水左紀、渡辺善照、安東星
- Organizer
  第26回日本DDS学会
- Place of Presentation
  大阪国際交流センター(大阪市)
- Year and Date
  2010-06-18
- Data Source
  KAKENHI-PROJECT-21590178
[Presentation] Development of a novel therapeutic system of adenovirus gene therapy in combination of macromolecular drug therapy2010
- Author(s)
  Y.Watanabe, N.Koizumi, Y.Yamagishi, E, Hagiwara, H.Mizuguchi, M.Fujii
- Organizer
  16^<th> World Congress of Basic and Clinical Pharmacology
- Place of Presentation
  Bella Center, Copenhagen市、Denmark国
- Year and Date
  2010-07-22
- Data Source
  KAKENHI-PROJECT-21590178
[Presentation] HIVイメージングシステムの開発2010
- Author(s)
  小泉直也、Suree Tom、清水佐紀、渡辺善照、安東星
- Organizer
  第26回日本DDS学会
- Place of Presentation
  大阪府大阪市大阪国際交流センター
- Year and Date
  2010-06-18
- Data Source
  KAKENHI-PROJECT-21790161
[Presentation] Development of a novel therapeutic system of adenovirus gene therapy in combination ofmacromolecular drug therapy2010
- Author(s)
  Y. Watanabe, N. Koizumi, Y. Yamagishi, E, Hagiwara, H. Mizuguchi, M. Fujii
- Organizer
  16^<th> World Congress of Basic and Clinical Pharmacology
- Place of Presentation
  Bella Center, Copenhagen, Denmark
- Year and Date
  2010-07-22
- Data Source
  KAKENHI-PROJECT-21590178
[Presentation] ヒト結腸由来Caco-2細胞におけるtight junction分子機構の解析を目的としたclaudin発現システムの確立2009
- Author(s)
  仙内光子,山岸喜彰,小泉直也,水口裕之,近藤昌夫,八木清人,藤井まき子,渡辺善照
- Organizer
  日本薬学会第129年会
- Data Source
  KAKENHI-PROJECT-19590159
[Presentation] アデノウイルスシャフト蛋白質によるFITC-dextranの細胞内取り込み機構の解明2009
- Author(s)
  小泉直也,山岸喜彰,萩原恵理,岩島順子,水口裕之,藤井まき子,渡辺善照
- Organizer
  日本薬学会129年会
- Data Source
  KAKENHI-PROJECT-19590159
[Presentation] ウエルシュ菌エンテロトキシンC末断片(C-CPE)作用時の小腸粘膜上皮細胞における変動遺伝子の解析2008
- Author(s)
  仙内光子,小泉直也,大内可成子,浜田華香,近藤昌夫,藤井まき子,八木清仁,渡辺善照
- Organizer
  日本薬学会第128年会
- Data Source
  KAKENHI-PROJECT-19590159
[Presentation] Development of efficient gene transfer system into Caco-2 cell monolayer by adenovirus vector2008
- Author(s)
  Naoya Koizumi, Yoshiaki Yamagishi, Hiroyuki Mizuguchi, Makiko Fujii and Yoshiteru Watanabe
- Organizer
  Pan-Pacific International Partnership Conference on Pharmaceutical and Life Sciences
- Place of Presentation
  4^<th> US-Japan Joint Conference
- Data Source
  KAKENHI-PROJECT-19590159
[Presentation] アデノウイルスベクターを用いたCaco-2単層膜細胞への効率的遺伝子導入方法の開発2008
- Author(s)
  山岸喜彰, 小泉直也, 水口裕之, 藤井まき子, 渡辺善照
- Organizer
  遺伝子デリバリー研究会第8回シンポジウム
- Place of Presentation
  大阪
- Year and Date
  2008-05-19
- Data Source
  KAKENHI-PROJECT-19790135
[Presentation] アデノウイルスカプシド蛋白質を利用した効率的遺伝子導入法の開発2008
- Author(s)
  小泉直也,萩原恵理,岩島順子,山岸喜彰,水口裕之,藤井まき子,渡辺善照
- Organizer
  第24回日本DDS学会
- Data Source
  KAKENHI-PROJECT-19590159
[Presentation] DEVELOPMENT OF EFFICIENT GENE TRANSFER SYSTEMS INTO CACO-2 CELL MONOLAYER BY ADENOVIRUS VECTOR2008
- Author(s)
  Naoya Koizumi, Yoshiaki Yamagishi, Hiroyuki Mizuguchi, Makiko Fujii, Yoshiteru Watanabe
- Organizer
  4th Pan-Pacific International Partnership Conference on Pharmaceutical and Life Sciences
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-19790135
[Presentation] アデノウイルスカプシド蛋白質を利用した効率的遺伝子導入法の開発2008
- Author(s)
  小泉直也、萩原恵理、岩島順子、山岸喜彰、水口裕之、藤井まき子、渡辺善照
- Organizer
  第24回日本DDS学会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-19790135
[Presentation] DEVELOOPMENT OF EFFICIENT GENE TRANSFER SYSTEMS INTO CACO-2 CELL MONOLAYER BY ADENOVIRUS VECTOR2008
- Author(s)
  Naoya, Koizumi・Tomomi, Sasaki・Hiroyuki, Mizuguchi・Makiko, Fujii・Yoshiteru, Watanabe
- Organizer
  4th Pan-Pacific International Partnership Conference on Pharmaceutical and Life Sciences
- Place of Presentation
  愛知県名古屋市
- Data Source
  KAKENHI-PROJECT-19790135
[Presentation] Efficient gene transfer into human Intestinal epithelial model with Adenovirus vector2008
- Author(s)
  Yoshiteru Watanabe, Naoya Koizumi,Hiroyuki Mizuguchi and Makiko Fujii
- Organizer
  The Ixth WorldConference on Clinical Pharmacology and Therapeutics
- Data Source
  KAKENHI-PROJECT-19590159
[Presentation] DEVELOPMENT OF EFFICIENT GENE TRANSFER SYSTEMS INTO CACO-2 CELL MONOLAYER BY ADENOVIRUS VECTOR2008
- Author(s)
  Naoya Koizumi, Yoshiteru Watanabe, et. al.
- Organizer
  4th Pan-Pacific International Partnership Conference on Pharmaceutical and Life Sciences
- Place of Presentation
  愛知県名古屋市
- Data Source
  KAKENHI-PROJECT-19590159
[Presentation] アデノウイルスカプシド蛋白質を利用した効率的遺伝子導入方法の開発2008
- Author(s)
  小泉直也, 渡辺善照, 他
- Organizer
  第24回日本DDS学会
- Place of Presentation
  東京都
- Data Source
  KAKENHI-PROJECT-19590159
[Presentation] アデノウイルスベクターを用いたCaco-2単層膜細胞への効率的遺伝子導入方法の開発遺伝子デリバリー研究会2008
- Author(s)
  山岸喜彰、小泉直也、水口裕之、藤井まき子、渡辺善照
- Organizer
  第8回シンポジウム
- Place of Presentation
  大阪
- Year and Date
  2008-06-09
- Data Source
  KAKENHI-PROJECT-19790135
[Presentation] Infectious mechanism of adenovirus vector in Caco-2 cell for permeability study using a transgene expressed intestinal epithelium model2007
- Author(s)
  Naoya Koizumi, Tomomi Sasaki, Hiroyuki Mizuguchi, Makiko Fujii and Yoshiteru Watanabe
- Organizer
  8th International ISSX meeting
- Data Source
  KAKENHI-PROJECT-19590159
[Presentation] Infectious mechanism of adenovirus vector in Caco-2 cell for permeability study using a transgene expressed intestinal epithelium model2007
- Author(s)
  Naoya, Koizumi・Tomomi, Sasaki・Hiroyuki, Mizuguchi・Makiko, Fujii・Yoshiteru, Watanabe
- Organizer
  8th International Society for the Study of Xenobi otics Meeting
- Place of Presentation
  宮城県仙台市
- Data Source
  KAKENHI-PROJECT-19790135
[Presentation] Infectious mechanism of adenovirus vector in Caco-2 cell for permeability study using a transgene expressed intestinal epithelium model2007
- Author(s)
  Naoya Koizumi, Tomomi Sasaki, Hiroyuki Mizuguchi, Makiko Fujii, Yoshiteru Watanabe
- Organizer
  8th International Society for the Study of Xenobiotics Meeting
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-19790135
[Presentation] Infectious mechanism of adenovirus vector in Caco-2 cell for permeability study using a transgene expressed intestinal epithelium model2007
- Author(s)
  Naoya Koizumi, Yoshiteru Watanabe, et. al.
- Organizer
  8th International ociety for the Study of Xenobiotics Meeting
- Place of Presentation
  宮城県仙台市
- Data Source
  KAKENHI-PROJECT-19590159
[Presentation] 外部環境が及ぼすアデノウイルス由来細胞膜透過ペプチドの細胞膜結合能への影響
- Author(s)
  平井孝昌、小泉直也、北村健太、平間奈苗、藤井まき子、水口裕之、渡辺善照
- Organizer
  日本薬学会第135年会
- Place of Presentation
  神戸サンボーホール　（神戸市）
- Year and Date
  2015-03-26 – 2015-03-28
- Data Source
  KAKENHI-PROJECT-25460222
[Presentation] Sec61β regulates barrier functions of tight junction via the expression of Claudin-4 in epithelial cells
- Author(s)
  Watanabe Y, Wahiyama M, Koizumi N, Fujii M.
- Organizer
  5th FIP Pharmaceutical Sciences World Congress
- Place of Presentation
  Melbourne Convention and Exhibition Centre (Melbourne, Australia)
- Year and Date
  2014-04-13 – 2014-04-16
- Data Source
  KAKENHI-PROJECT-25460222
[Presentation] 卵白アルブミン特異的抗体産生に及ぼすナノ粒子の影響
- Author(s)
  増田年紀，藤井まき子，伊達友哉，佐藤あんな，小泉直也，渡辺善照
- Organizer
  第57回日本薬学会関東支部大会
- Place of Presentation
  帝京大学（東京）
- Data Source
  KAKENHI-PROJECT-24590212
[Presentation] Effect of claudin-4 expression on the barrier function of tight in epithelial cells treated with TNF-α
- Author(s)
  Watanabe Y, Matsumoto Y, Koizumi N, Fujii M.
- Organizer
  74th FIP World Congress of Pharmacy and Pharmaceutical Sciences 2014
- Place of Presentation
  Bangkok International Trade and Exhibition Centre (Bangkok, Thailand)
- Year and Date
  2014-08-30 – 2014-09-04
- Data Source
  KAKENHI-PROJECT-25460222
[Presentation] 細胞膜透過促進能を持つアデノウイルスshaftタンパク質の結合要因の解析
- Author(s)
  北村健太、小泉直也、野中美和、志田健太、平間奈苗、藤井まき子、水口裕之、渡辺善照
- Organizer
  第30回日本DDS学会学術集会
- Place of Presentation
  慶應義塾大学薬学部　(東京都港区）
- Year and Date
  2014-07-30 – 2014-07-31
- Data Source
  KAKENHI-PROJECT-25460222

1. WATANABE Yoshiteru (70175131)

# of Collaborated Projects: 6 results

# of Collaborated Products: 45 results
2. FUJII Makiko (50199296)

# of Collaborated Projects: 6 results

# of Collaborated Products: 36 results
3. KONDOH Masuo (50309697)

# of Collaborated Projects: 5 results

# of Collaborated Products: 9 results
4. WATANABE Yoshiteru (70175731)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 田口博之 (60236403)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 橋崎要 (60318459)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Koizumi Naoya 小泉 直也

KOIZUMI Naoya 小泉 直也

Research Projects

Research Products

Co-Researchers

development of a therapeutic carrier protein for gene therapyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of nano-composite particle for transdermal vaccination system

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Strategic approach based on molecular mechanism for modulation of barrier function of tight junction to enhance delivery of new biopharmaceuticals

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The development of protein delivery system through the cell membranePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of dermal vaccine system targeting hair follicle with nanoparticle

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Basic Study of orally-delivered vaccine development using a new innate immunity inducerPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Studies of barrier function of tight junction in epithelial celllayers and strategic development of novel methods for drug permeation enhancement in cells

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of tissue specific siRNA expression system to vascular endothelial cells in cancerPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

A Novel Strategy for Enhancement of Permeation and Absorption of Drugs by Modulation of Proteins Constructed Barrier Function in Biomembrane

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of fiber modified adenovirus vectorPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

細胞内動態を制御したアデノウイルスベクターの開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Studies on Drug Permeation in Placental Barrier by RNA Interference

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Efficient Adenovirus Gene Transter Methods in Human Cononic Caco-2 Epithelial Cells Using Capric Acid2015

Author(s)

Journal Title

Koizumi Naoya 小泉直也

KOIZUMI Naoya 小泉直也