OGIHARA Takuo 荻原琢男

Researcher Number	80448886
Other IDs
Affiliation *help	2010 – 2018 : 高崎健康福祉大学, 薬学部, 教授 2007 – 2008 : 高崎健康福祉大学, 薬学部, 教授
Review Section/Research Field	Principal Investigator Basic Section 47060:Clinical pharmacy-related / Medical pharmacy / Applied pharmacology Except Principal Investigator Applied pharmacology / Eating habits / Medical pharmacy
Keywords	Principal Investigator radixin / がん多剤耐性 / P-糖タンパク / トランスポーター / 多剤耐性 / 消化管吸収 / 組織選択性 / ＥＲＭタンパク / 腎臓がん / 輸送活性 … More Except Principal Investigator トランスポーター / 消化管吸収 / 相互作用 / PEPT1 / P-糖蛋白質 / 消化管 / 尿毒症 / ミルク / 小腸 / 腎不全 / 血液脳関門 / インドキシル硫酸 / 薬物相互作用 / 薬物-食物間相互作用 / セシウム / 消化管分泌 / ABC transporter / 医薬品副作用 / アルギン酸 / 臨床試験 / 排泄促進 / P-糖タンパク質 / 結合定数 / オセルタミビル / 価数 / 消化管吸 / PEPT-1 / イオン半径 / 重金属 / Indoxyl Sulfate Less

Mechanism and clinical prediction of drug resistance associated with epithelial mesenchymal transition of lung cancerPrincipal InvestigatorOngoing
- Principal Investigator
  
  荻原琢男
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Takasaki University of Health and Welfare
膜裏打ちタンパクの制御による臓器特異的ながん多剤耐性の非働化Principal InvestigatorOngoing
- Principal Investigator
  
  荻原琢男
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  Takasaki University of Health and Welfare
Evaluation of the intestinal secretion of indoxyl sulfate as a possible compensative excretion pathway in chronic kidney disease
- Principal Investigator
  
  MORIMOTO Kaori
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  Tohoku Pharmaceutical University
Study of alginate's effect and mechanism, enhancing excretion and reducing absorption of strontium and cesium.
- Principal Investigator
  
  Idota Yoko
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Eating habits
- Research Institution
  Takasaki University of Health and Welfare
The construction of a means to overcome cancerous multidrug resistance by mediating the post-translational regulators of drug-efflux transportersPrincipal Investigator
- Principal Investigator
  
  OGIHARA Takuo
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Applied pharmacology
- Research Institution
  Takasaki University of Health and Welfare
Effect of Food on the Intestinal PEPT1-mediated Drug Absorption
- Principal Investigator
  
  MORIMOTO Kaori
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Applied pharmacology
- Research Institution
  Takasaki University of Health and Welfare
The mechanism and its inter-individual variability of the Blood-Brain Barrier penetration of anti-influenza drug, oseltamivir
- Principal Investigator
  
  MORIMOTO Kaori
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Applied pharmacology
- Research Institution
  Takasaki University of Health and Welfare

All 2016 2015 2014 2013 2012 2011 2009 2008 Other

All Journal Article Presentation Book

[Book] 実践製剤学－そしてその基礎となる物理薬剤学2015
- Author(s)
  安藤英紀，飯村菜穂子，石田竜弘，井戸田陽子，荻原琢男
- Total Pages
  519
- Publisher
  京都廣川書店
- Data Source
  KAKENHI-PROJECT-15K08078
[Book] 実践　製剤学　そしてその基盤となる物理薬剤学2015
- Author(s)
  安藤英紀, 飯村菜穂子, 石田竜弘, 井戸田陽子, 荻原琢男
- Total Pages
  519
- Publisher
  京都廣川書店
- Data Source
  KAKENHI-PROJECT-25560062
[Book] 2 試料の調製および分析法, 薬剤学実験法必携マニュアル Pharmaceutical Scientistのために Ⅱ 生物薬剤学2014
- Author(s)
  荻原琢男, 井戸田陽子
- Total Pages
  423
- Publisher
  南江堂
- Data Source
  KAKENHI-PROJECT-25560062
[Book] 第1章総論, わかりやすい生物薬剤学第5版2014
- Author(s)
  荻原琢男
- Total Pages
  10
- Publisher
  廣川書店
- Data Source
  KAKENHI-PROJECT-24590667
[Book] 薬剤学実験法必携マニュアル2014
- Author(s)
  荻原琢男、井戸田陽子
- Total Pages
  768
- Publisher
  南江堂
- Data Source
  KAKENHI-PROJECT-25560062
[Book] 2 試料の調製および分析法, 薬剤学実験法必携マニュアル Pharmaceutical Scientistのために Ⅱ 生物薬剤学2014
- Author(s)
  荻原琢男, 井戸田陽子
- Total Pages
  14
- Publisher
  南江堂
- Data Source
  KAKENHI-PROJECT-24590667
[Book] 薬剤学実験法必携マニュアル　生物薬剤学2013
- Author(s)
  荻原琢男，井戸田陽子
- Total Pages
  423
- Publisher
  日本薬剤学会出版委員会（南江堂）
- Data Source
  KAKENHI-PROJECT-24590667
[Book] ＤＤＳ製剤の開発・評価と実用化手法2013
- Author(s)
  荻原琢男，井戸田陽子
- Total Pages
  680
- Publisher
  技術情報協会
- Data Source
  KAKENHI-PROJECT-24590667
[Book] DDS製剤の開発・評価と実用化手法,2013
- Author(s)
  荻原琢男,　井戸田陽子
- Publisher
  技術情報協会
- Data Source
  KAKENHI-PROJECT-24590667
[Book] トランスポーター科学最前線2008
- Author(s)
  荻原琢男ら
- Publisher
  京都廣川書店
- Data Source
  KAKENHI-PROJECT-19599023
[Book] 創薬支援研究の展望2008
- Author(s)
  荻原琢男ら
- Publisher
  株式会社シーエムシー出版
- Data Source
  KAKENHI-PROJECT-19599023
[Book] トランスポーター科学最前線2008
- Author(s)
  荻原琢男、森本かおり
- Publisher
  京都廣川書店
- Data Source
  KAKENHI-PROJECT-19599023
[Book] 創薬支援研究の展望2008
- Author(s)
  荻原琢男、森本かおり、玉井郁巳
- Publisher
  株式会社シーエムシー出版
- Data Source
  KAKENHI-PROJECT-19599023
[Journal Article] Adenovirus vector infection of non-small-cell lung cancer cells is a trigger for multi-drug resistance mediated by P-glycoprotein2016
- Author(s)
  T. Tomono, M. Kajita, K. Yano, T. Ogihara
- Journal Title
  
  Biochem. and Biophys. Res. Commun.
  
  Volume : 476(4) Pages : 183-187
- DOI
  10.1016/j.bbrc.2016.05.070
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K08078
[Journal Article] Cholesterol-lowering Effect of Calcium Alginate in Rats2016
- Author(s)
  Yoko Idota, Yumi Kogure, Takako Kato, Mana Ogawa, Shoko Kobayashi, Chihaya Kakinuma, Kentaro Yano, Hiroshi Arakawa, Chihiro Miyajima, Fumiyoshi Kasahara, Takuo Ogihara
- Journal Title
  
  Biol. Pharm. Bull
  
  Volume : 39 Pages : 62-67
- DOI
  10.1248/bpb.b15-00503
- Peer Reviewed / Open Access / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25560062, KAKENHI-PROJECT-15H02894
[Journal Article] Different regulation of P-glycoprotein function between Caco-2 and Caki-1 cells by ezrin, radixin and moesin proteins.2016
- Author(s)
  Yano K, Otsuka K, Kato Y, Kawabata H, Ohmori S, Arakawa H, Ogihara T.
- Journal Title
  
  J. Pharm. Pharmacol.
  
  Volume : 68 Pages : 361-367
- DOI
  10.1111/jphp.12525
- Peer Reviewed / Open Access / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K08078, KAKENHI-PROJECT-15K19014
[Journal Article] Interaction of Peptide Transporter 1 With d-Glucose and l-Glutamic Acid; Possible Involvement of Taste Receptors.2016
- Author(s)
  Arakawa H, Ohmachi T, Ichiba K, Kamioka H, Tomono T, Kanagawa M, Idota Y, Hatano Y, Yano K, Morimoto K, Ogihara T.
- Journal Title
  
  J. Pharm. Sci.
  
  Volume : 105 Pages : 339-342
- DOI
  10.1016/j.xphs.2015.11.024
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K08078, KAKENHI-PROJECT-25560062
[Journal Article] Possible interaction of quinolone antibiotics with peptide transporter 1 in oral absorption of peptide-mimetic drugs.2016
- Author(s)
  Arakawa H, Kamioka H, Kanagawa M, Hatano Y, Idota Y, Yano K, Morimoto K, Ogihara T.
- Journal Title
  
  Biopharm Drug Dispos.
  
  Volume : 37 Pages : 39-45
- DOI
  10.1002/bdd.1999
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K08078
[Journal Article] Multiple Linear Regression Analysis Indicates Association of P-Glycoprotein Substrate or Inhibitor Character with Bitterness Intensity, Measured with a Sensor2015
- Author(s)
  Kentaro Yano, Suzune Mita, Kaori Morimoto, Tamami Haraguchi, Hiroshi Arakawa, Miyako Yoshida, Fumiyoshi Yamashita, Takahiro Uchida, Takuo Ogihara
- Journal Title
  
  Journal of pharmaceutical sciences
  
  Volume : 104
- DOI
  10.1002/jps.24232
- Peer Reviewed / Open Access / Acknowledgement Compliant
- Data Source
  KAKENHI-ORGANIZER-22136001, KAKENHI-PLANNED-23136102, KAKENHI-PROJECT-24590667, KAKENHI-PROJECT-25670073
[Journal Article] Recommended Daily Dose of Sesame Lignans Has No Influence on Oral Absorption of P-Glycoprotein Substrates in Rats.2015
- Author(s)
  Tomono T, Otsuka K, Yano K, Kanagawa M, Arakawa H, Ogihara T.
- Journal Title
  
  Biol Pharm Bull.
  
  Volume : 38 Pages : 1960-1963
- DOI
  10.1248/bpb.b15-00392
- Peer Reviewed / Open Access / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K08078
[Journal Article] Characterization of Cesium Uptake Mediated by a Potassium Transport System of Bacteria in a Soil Conditioner2014
- Author(s)
  P. Zhang, Y. Idota, K. Yano, M. Negishi, H. Kawabata, H. Arakawa, K. Morimoto, A. Tsuji, T. Ogihara
- Journal Title
  
  Biol. Pharm. Bull.
  
  Volume : 37 Pages : 604-607
- DOI
  10.1248/bpb.b13-00871
- Peer Reviewed / Open Access / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25560062
[Journal Article] A new high-throughput analysis for drug metabolism profiling using liquid chromatography coupled with tandem mass spectrometry,2013
- Author(s)
  K. Kusumoto,　T. Nagao, T. Ogihara
- Journal Title
  
  Drug Res.
  
  Volume : 63 Pages : 1-6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590667
[Journal Article] The Role of Inter-segmental Differences in P-glycoprotein expression and activityalong the rat small intestine in causing the double-peak phenomenon of substrate plasma concentration2013
- Author(s)
  Wada S, Kano T, Mita S, Idota Y, Morimoto K, Yamashita F, Ogihara T.
- Journal Title
  
  Drug Metab Pharmacokinet.
  
  Volume : Vo.28 Pages : 98-103
- URL
  https://www.jstage.jst.go.jp/article/dmpk/28/2/28_DMPK-12-RG-005/_article
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590505
[Journal Article] Clinical impact and evidence of pharmacokinetic change by genetic polymorphism2013
- Author(s)
  T. Ogihara
- Journal Title
  
  Drug Metab. Pharmacokinet,
  
  Volume : 28 Pages : 3-3
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590667
[Journal Article] Contribution of radixin to P-glycoprotein expression and transport activity in mouse small intestine in vivo2013
- Author(s)
  Yano K, Tomono T, Sakai R, Kano T, Morimoto K, Kato Y, Ogihara T.
- Journal Title
  
  J Pharm Sci.
  
  Volume : 102（8） Pages : 2875-81
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590667
[Journal Article] The role of inter-segmental differences in P-glycoprotein expression and activity along the rat small intestine in causing the double-peak phenomenon of substrate plasma concentration2013
- Author(s)
  S. Wada, T. Kano, S. Mita, Y. Idota, K. Morimoto, F. Yamashita, T. Ogihara
- Journal Title
  
  Drug Metab.Pharmacokinet .
  
  Volume : 28 Pages : 98-103
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590667
[Journal Article] Alginate enhances excretion and reduces absorption of strontium and cesium in rats2013
- Author(s)
  dota Ｙ, Harada Ｈ, Tomono Ｔ, Kobayashi S, Kaminuma C, Miyajima C, Kasahara F, Ogihara T
- Journal Title
  
  Biol.Pharm.Bull.
  
  Volume : 36 Pages : 485-491
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590667
[Journal Article] Challenges of drug delivery Systems that contribute to cancer chemotherapy2013
- Author(s)
  T. Ogihara
- Journal Title
  
  Biol.Pharm.Bull.
  
  Volume : 36 Pages : 691-691
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590667
[Journal Article] Role of inter-segmental differences in P-glycoprotein expression and activity along rat small intestine in causing double-peak phenomena of substrate plasma concentration2013
- Author(s)
  Sho Wada, Takashi Kano,Suzune Mita, Yoko Idota, Kaori Morimoto, Fumiyoshi Yamashita, Takuo Ogihara
- Journal Title
  
  Drug Metabolism and Pharmacokinetics
  
  Volume : 28 Pages : 98-103
- DOI
  10.2133/dmpk.DMPK-12-RG-005
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590667, KAKENHI-PLANNED-23136102
[Journal Article] Developmental changes of brain distribution and localization of oseltamivir and its active metabolite Ro 64-0802 in rats2012
- Author(s)
  Morimoto K, Nagami T, Matsumoto N, Wada S, Kano T, Kakinuma, Ogihara T
- Journal Title
  
  J Toxicol Sci
  
  Volume : Vol.37 Pages : 1217-1223
- URL
  https://www.jstage.jst.go.jp/article/jts/37/6/37_1217/_pdf
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590505
[Journal Article] Transport mechanisms of flavanone aglycones across Caco-2 cell monolayers and artificial PAMPA membranes2012
- Author(s)
  Kobayashi S, Nagai T, Konishi Y, Tanabe S, Morimoto K, Ogihara T
- Journal Title
  
  Journal of Pharmacy and Pharmacology
  
  Volume : Vol.61 Pages : 52-60
- DOI
  10.1111/j.2042-7158.2011.01374.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590505, KAKENHI-PROJECT-22700761
[Journal Article] Species difference of esterase expression and hydrolase activity in plasma2012
- Author(s)
  Bahar F.G., Ohura K., Ogihara T., Imai T
- Journal Title
  
  J. Pharm. Sci
  
  Volume : Vol. 101 Pages : 3979-3988
- DOI
  10.1002/jps.23258
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590505
[Journal Article] Effect of milk on the pharmacokinetics of oseltamivir in healthy volunteers2011
- Author(s)
  Morimoto K, Kishimura K, Nagami T, Kodama N, Ogama Y, Yokoyama M, Toda S, Chiyoda T, Shimada R, Inano A, Kano T, Tamai I, Ogihara T
- Journal Title
  
  J. Pharm. Sci
  
  Volume : Vol.100 Pages : 3854-3861
- DOI
  10.1002/jps.22627
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590505
[Journal Article] 食品成分と薬物の相互作用2011
- Author(s)
  小林彰子, 森本かおり, 荻原琢男
- Journal Title
  
  BIOINDUSTRY
  
  Volume : 28巻 Pages : 30-35
- URL
  http://www.fujisan.co.jp/product/1281680662/b/691304/
- Data Source
  KAKENHI-PROJECT-22590505
[Journal Article] Oseltamivir (Tamiflu^<TM>)is a substrate of PEPT12009
- Author(s)
  Takuo Ogihara, et al.
- Journal Title
  
  Drug Metab Dispos (掲載確定)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19599023
[Journal Article] Oseltamivir (Tamiflu) Efflux Transport at the Blood-Brain Barrier via P-glycoprotein.2008
- Author(s)
  Morimoto K, Nakakariya M, Shirasaka Y, Kakinuma C, Fujita T, Tamai I, Ogihara T.
- Journal Title
  
  Drug Metab Dispos 36
  
  Pages : 6-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19599023
[Journal Article] Oseltamivir (Tamiflu^<TM>) is a substrate of PEPT1.
- Author(s)
  Ogihara T, Kano T, Wagatsuma T, Wada S, Yabuuchi H, Enomoto S, Morimoto K, Shirasaka Y, Kobayashi S, Tamai I.
- Journal Title
  
  Drug Metab Dispos in press
  
  Pages : 0-0
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19599023
[Presentation] Snail過剰発現によるEMTはHCC827細胞におけるBCRPの発現を低下させる2016
- Author(s)
  伴野拓巳, 矢野健太郎, 荻原琢男
- Organizer
  日本薬剤学会第31年会
- Place of Presentation
  岐阜
- Year and Date
  2016-05-19
- Data Source
  KAKENHI-PROJECT-15K08078
[Presentation] 肺腺がん細胞へのアデノウイルス感染はAktのリン酸化を介してP-gpの発現を亢進する2016
- Author(s)
  柴﨑由実, 伴野拓巳, 矢野健太郎, 荻原琢男
- Organizer
  日本薬剤学会第31年会
- Place of Presentation
  岐阜
- Year and Date
  2016-05-19
- Data Source
  KAKENHI-PROJECT-15K08078
[Presentation] 肺がん細胞へのリチウム処理によるMRPファミリーの機能変動2016
- Author(s)
  柴﨑由実、伴野拓巳、矢野健太郎、荻原琢男
- Organizer
  第60回日本薬学会関東支部大会
- Place of Presentation
  東京
- Year and Date
  2016-09-17
- Data Source
  KAKENHI-PROJECT-15K08078
[Presentation] 非小細胞性肺がん細胞へのアデノウイルス感染がBCRPおよびMRPファミリーに及ぼす影響2016
- Author(s)
  伴野拓巳, 矢野健太郎, 荻原琢男
- Organizer
  第11回トランスポーター研究会年会
- Place of Presentation
  京都
- Year and Date
  2016-07-02
- Data Source
  KAKENHI-PROJECT-15K08078
[Presentation] ヒト腎臓がん細胞のP-gp およびMRPs 輸送機能における足場タンパクの関与2016
- Author(s)
  加藤木綿子、矢野健太郎、井戸田陽子、荒川大、荻原琢男
- Organizer
  日本薬学会第136年会
- Place of Presentation
  横浜
- Year and Date
  2016-03-26
- Data Source
  KAKENHI-PROJECT-15K08078
[Presentation] 消化管ホルモンであるコレシストキニンによるP-gp機能調節2016
- Author(s)
  矢野健太郎、清水里織、荻原琢男
- Organizer
  日本薬物動態学会第31年会
- Place of Presentation
  松本
- Year and Date
  2016-10-13
- Data Source
  KAKENHI-PROJECT-15K08078
[Presentation] Cholesterol-lowering Effect of Calcium Alginate in Rats2016
- Author(s)
  Takuo OGIHARA, Yoko IDOTA, Yumi KOGURE, Takako KATO, Mana OGAWA, Shoko KOBAYASHI, Chihaya KAKINUMA, Kentaro YANO, Hiroshi ARAKAWA, Chihiro MIYAJIMA, Fumiyoshi KASAHARA
- Organizer
  日本農芸化学会2016年度大会
- Place of Presentation
  札幌市教育文化会館（北海道札幌市）
- Year and Date
  2016-03-27
- Data Source
  KAKENHI-PROJECT-25560062
[Presentation] BCRPを介した脳興奮物質であるSpermineの排出2016
- Author(s)
  横塚弥衣、松本映子、矢野健太郎、荻原琢男
- Organizer
  日本薬物動態学会第31年会
- Place of Presentation
  松本
- Year and Date
  2016-10-13
- Data Source
  KAKENHI-PROJECT-15K08078
[Presentation] Snail過剰発現によるP-gp機能亢進におけるCaveolin-1リン酸化の関与2016
- Author(s)
  伴野拓巳、矢野健太郎、荻原琢
- Organizer
  日本薬物動態学会第31年会
- Place of Presentation
  松本
- Year and Date
  2016-10-13
- Data Source
  KAKENHI-PROJECT-15K08078
[Presentation] Tissue-selective regulation of P-gp function in cancers by ERM proteins2015
- Author(s)
  矢野　健太郎、大塚　杏磨、加藤　木綿子、井戸田　陽子、荒川　大、荻原　琢男
- Organizer
  日本薬物動態学会第30年会
- Place of Presentation
  東京　タワーホール船堀
- Year and Date
  2015-11-12
- Data Source
  KAKENHI-PROJECT-15K08078
[Presentation] Utility of three-dimensional culture of human hepatocyte as a tool of drug metabolizing enzyme induction2015
- Author(s)
  荒川　大、上岡　宏紀、井戸田　陽子、矢野　健太郎、荻原　琢男
- Organizer
  日本薬物動態学会第30年会
- Place of Presentation
  東京　タワーホール船堀
- Year and Date
  2015-11-12
- Data Source
  KAKENHI-PROJECT-15K08078
[Presentation] 日米EU3局の薬物相互作用ガイドラインの概要まとめと比較2015
- Author(s)
  山田　浩行、荒川　大、楠本　久美子、小島　肇、荻原　琢男
- Organizer
  第59回日本薬学会関東支部大会
- Place of Presentation
  船橋
- Year and Date
  2015-09-12
- Data Source
  KAKENHI-PROJECT-15K08078
[Presentation] Transcriptional factor Snail activates P-glycoprotein function in lung adenocarcinoma cells2015
- Author(s)
  伴野　拓巳、矢野　健太郎、荒川　大、荻原　琢男
- Organizer
  日本薬物動態学会第30年会
- Place of Presentation
  東京　タワーホール船堀
- Year and Date
  2015-11-12
- Data Source
  KAKENHI-PROJECT-15K08078
[Presentation] 基質薬物とキノロン系抗菌薬との消化管吸収過程における相互作用2015
- Author(s)
  荻原　琢男、上岡　宏紀、金川　雅彦、井戸田　陽子、矢野　健太郎、森本　かおり、荒川　大
- Organizer
  第37回生体膜と薬物の相互作用シンポジウム
- Place of Presentation
  熊本
- Year and Date
  2015-11-19
- Data Source
  KAKENHI-PROJECT-15K08078
[Presentation] 服用者および調剤者の立場からの既存錠2錠と倍量大型錠1錠の比較検討2015
- Author(s)
  金井佑樹, 矢野健太郎, 井戸田陽子, 荒川大, 井上拓民, 林正弘, 荻原琢男
- Organizer
  第11回群馬県薬剤師学会学術大会
- Place of Presentation
  ベイシア文化ホール（群馬県前橋市）
- Year and Date
  2015-05-31
- Data Source
  KAKENHI-PROJECT-25560062
[Presentation] アルギン酸による重金属吸着作用の解析2015
- Author(s)
  荻原琢男, 井戸田陽子, 加藤多佳子, 矢野健太郎, 荒川大, 安竹良礼, 宮島千尋, 笠原文善
- Organizer
  第42回日本毒性学会学術年会
- Place of Presentation
  石川県立音楽堂（石川県金沢市）
- Year and Date
  2015-06-29
- Data Source
  KAKENHI-PROJECT-25560062
[Presentation] 初代ヒト肝細胞三次元培養法の薬物代謝酵素誘導試験における有用性2015
- Author(s)
  荒川大, 上岡宏紀, 井戸田陽子, 矢野健太郎, 荻原琢男
- Organizer
  日本薬物動態学会第30回年会
- Place of Presentation
  タワーホール船堀（東京都江戸川区）
- Year and Date
  2015-11-12
- Data Source
  KAKENHI-PROJECT-25560062
[Presentation] 基質薬物とキノロン系抗菌薬との　消化管吸収過程における相互作用2015
- Author(s)
  荻原琢男, 上岡宏紀, 金川雅彦, 井戸田陽子, 矢野健太郎, 森本かおり, 荒川大
- Organizer
  第37回生体膜と薬物の相互作用シンポジウム
- Place of Presentation
  熊本大学薬学部大江キャンパス（熊本県熊本市）
- Year and Date
  2015-11-19
- Data Source
  KAKENHI-PROJECT-25560062
[Presentation] 尿毒症物質インドキシル硫酸の消化管分泌機構の解析2015
- Author(s)
  富永雄太、森本かおり、宮本将成、柏倉正太、高橋昂、佐野芳美、矢野健太郎、荻原琢男、富田幹雄
- Organizer
  日本薬物動態学会第３０年会
- Place of Presentation
  タワーホール船堀（東京都江戸川区）
- Year and Date
  2015-11-12
- Data Source
  KAKENHI-PROJECT-25460196
[Presentation] インドキシル硫酸の代償性排泄経路としての消化管分泌の関与2015
- Author(s)
  富永雄太、森本かおり、宮本将成、柏倉正太、高橋昂、佐野芳美、矢野健太郎、荻原琢男、富田幹雄
- Organizer
  第９回日本腎臓病薬物療法学会学術集会・総会2015
- Place of Presentation
  仙台国際センター(宮城県仙台市）
- Year and Date
  2015-10-24
- Data Source
  KAKENHI-PROJECT-25460196
[Presentation] がん組織におけるERMタンパクによるP-gp輸送機能の調節機構2015
- Author(s)
  加藤木綿子、矢野健太郎、大塚杏磨、荒川大、荻原琢男
- Organizer
  第8回トランスポーター研究会
- Place of Presentation
  慶応義塾大学薬学部
- Year and Date
  2015-06-20
- Data Source
  KAKENHI-PROJECT-15K08078
[Presentation] 尿毒症物質インドキシル硫酸の消化管粘膜透過機構の解析2014
- Author(s)
  宮本将成、我妻雄太、野呂悠佳、森本かおり、矢野健太郎、荻原拓男、富田幹雄．
- Organizer
  第53回日本薬学会東北支部大会
- Place of Presentation
  いわき明星大学（福島県いわき市）
- Year and Date
  2014-10-05
- Data Source
  KAKENHI-PROJECT-25460196
[Presentation] RadixinによるP-gp機能調節の臓器差2014
- Author(s)
  大塚杏磨, 矢野健太郎, 川端秀明, 金井祐樹, 伴野拓巳, 荒川大, 荻原琢男
- Organizer
  第58回日本薬学会関東支部大会
- Place of Presentation
  東京
- Year and Date
  2014-10-04
- Data Source
  KAKENHI-PROJECT-24590667
[Presentation] アルギン酸による血中コレステロール低下作用2014
- Author(s)
  安竹良礼, 井戸田陽子, 木暮悠美, 加藤多佳子, 矢野健太郎, 荒川大, 柿沼千早, 宮島千尋, 笠原文善, 小林彰子, 荻原琢男
- Organizer
  第58回日本薬学会関東支部大会
- Place of Presentation
  東京
- Year and Date
  2014-10-04
- Data Source
  KAKENHI-PROJECT-25560062
[Presentation] Double-peak phenomena caused by intestinal segmental difference of P-glycoprotein activity,2013
- Author(s)
  Wada S, Ogihara T, Nakanishi T, Tamai
- Organizer
  4th ISSX/CSSX Joint Workshop
- Place of Presentation
  Henan, China
- Data Source
  KAKENHI-PROJECT-24590667
[Presentation] In　vitroによる薬物代謝スクリーニングの現状と留意点,2013
- Author(s)
  荻原琢男,　井戸田陽子
- Organizer
  第40回日本毒性学会学術年会
- Place of Presentation
  千葉
- Data Source
  KAKENHI-PROJECT-24590667
[Presentation] Contribution of radixin to P-glycoprotein expression and transport activity2013
- Author(s)
  Yano K, Tomono T, Kawabata H, Idota Y, Morimoto K, Arakawa H, Ogihara T
- Organizer
  28ｔｈ JSSX Annual Meeting,
- Place of Presentation
  Ｔｏｋｙｏ
- Data Source
  KAKENHI-PROJECT-24590667
[Presentation] Contribution of radixin to P-glycoprotein expression and transport activity in mouse small intestine in vivo,2013
- Author(s)
  伴野拓巳,　矢野健太郎,　川端秀明,　荒川大,　荻原琢男
- Organizer
  第8回トランスポーター研究会年会
- Place of Presentation
  熊本
- Data Source
  KAKENHI-PROJECT-24590667
[Presentation] Alginate Enhances Excretion and Reduces Absorption of Strontium and Cesium in Rats2013
- Author(s)
  Yumi Kogure, Yoko Idota, Hitomi Harada, Shoko Kobayashi, Chihaya Kakinuma, Chihiro Miyajima, Fumiyoshi Kasahara, Takuo Ogihara
- Organizer
  Asian Federation for Pharmaceutical Sciences (AFPS) 2013 -アジア薬科学会議2013-
- Place of Presentation
  済州島, 韓国
- Data Source
  KAKENHI-PROJECT-25560062
[Presentation] Contribution of radixin in segmental difference of P-glycoprotein expression in small intestine2012
- Author(s)
  伴野　拓巳、酒井　理予、矢野　健太郎、叶　隆、森本　かおり、加藤　将夫、荻原　琢男
- Organizer
  日本薬物動態学会第27年会
- Place of Presentation
  千葉（タワーホール船堀）
- Data Source
  KAKENHI-PROJECT-24590667
[Presentation] Radixin is involved in P-glycoprotein expression in small intestine2012
- Author(s)
  酒井　理予、叶　隆、和田　翔、森本　かおり、荻原　琢男
- Organizer
  日本薬剤学会第27年会
- Place of Presentation
  神戸(神戸国際会議場）
- Data Source
  KAKENHI-PROJECT-24590667
[Presentation] Oseltamivir (Tamiflu^<TM>)is a substrate of PEPT12009
- Author(s)
  Takuo Ogihara, et al.
- Organizer
  3rd Asian Pacific Regional ISSX Meeting
- Place of Presentation
  Bangkok, Thailand(発表確定)
- Year and Date
  2009-05-11
- Data Source
  KAKENHI-PROJECT-19599023
[Presentation] Oseltamivir (Tamiflu^<TM>) is a substrate of PEPT1.2009
- Author(s)
  Ogihara T, et al.
- Organizer
  3rd Asia Pacific Regional ISSX Meeting
- Place of Presentation
  Bangkok, Thailand
- Year and Date
  2009-05-21
- Data Source
  KAKENHI-PROJECT-19599023
[Presentation] オセルタミビルはヒトペプチドトランスポーターPEPT1の基質である2009
- Author(s)
  荻原琢男ら
- Organizer
  日本薬学会第129年会
- Place of Presentation
  京都
- Year and Date
  2009-03-26
- Data Source
  KAKENHI-PROJECT-19599023
[Presentation] オセルタミビルはヒトペプチドトランスポーターPEPT1の基質である2009
- Author(s)
  荻原琢男ら
- Organizer
  日本薬学会第129年会
- Place of Presentation
  京都国際会館(京都)
- Year and Date
  2009-03-26
- Data Source
  KAKENHI-PROJECT-19599023
[Presentation] トランスポーター科学と薬物動態学の最前線,
- Author(s)
  出口芳春,　荻原琢男
- Organizer
  第57回日本薬学会関東支部大会,
- Place of Presentation
  東京
- Invited
- Data Source
  KAKENHI-PROJECT-24590667
[Presentation] 苦味センサーを用いたP-糖タンパクの基質認識性の解析
- Author(s)
  三田鈴音,　矢野健太郎,　荒川　大,　原口珠実,　吉田　都,　内田享弘,　荻原琢男
- Organizer
  第57回日本薬学会関東支部大会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24590667
[Presentation] SSRIおよびSNRIによるK+チャネル阻害作用のPK/PD解析
- Author(s)
  伴野拓巳, 橋場弘武, 矢野健太郎, 井戸田陽子, 荒川大, 林正弘, 荻原琢男
- Organizer
  第24回日本医療薬学会年会
- Place of Presentation
  名古屋
- Year and Date
  2014-09-27 – 2014-09-28
- Data Source
  KAKENHI-PROJECT-25560062
[Presentation] P-glycoprotein Plays a Key Role in the Contractionary Effects against Brain Infarction of
- Author(s)
  Takumi Tomono, Kentaro Yano, Toshimitsu Motegi, Shinobu Takimoto, Mihoko Hagiwara, Yoko Idota, Takashi Kano, Hiroshi Arakawa, Kaori Morimoto, Chihaya Kakinuma, Akira Takahara, Takuo Ogihara
- Organizer
  19th North American ISSX/29th JSSX Meeting
- Place of Presentation
  サンフランシスコ
- Year and Date
  2014-10-19 – 2014-10-23
- Data Source
  KAKENHI-PROJECT-24590667
[Presentation] 消化管P-糖タンパク質の輸送機能に対するゴマリグナンの影響
- Author(s)
  大塚杏磨, 伴野拓巳, 矢野健太郎, 金川雅彦, 荒川大, 荻原琢男
- Organizer
  第135回日本薬学会
- Place of Presentation
  神戸
- Year and Date
  2015-03-25 – 2015-03-28
- Data Source
  KAKENHI-PROJECT-24590667
[Presentation] 薬の運び屋トランスポーターその働きを培養細胞で観察しよう
- Author(s)
  荻原琢男
- Organizer
  日本学術振興会ひらめき☆ときめきサイエンス
- Place of Presentation
  高崎
- Invited
- Data Source
  KAKENHI-PROJECT-24590667
[Presentation] 高リン血症治療薬に対する併用注意剤の吸着性解析
- Author(s)
  安部有紀, 伴野拓巳, 秋山滋男, 井戸田陽子, 矢野健太郎, 荒川大, 磯野淳一, 林正弘, 荻原琢男
- Organizer
  第24回日本医療薬学会年会
- Place of Presentation
  名古屋
- Year and Date
  2014-09-27 – 2014-09-28
- Data Source
  KAKENHI-PROJECT-25560062
[Presentation] P-糖タンパク機能発現におけるRadixinの役割
- Author(s)
  川端秀明,　矢野健太郎,　伴野拓巳,　荒川　大,　荻原琢男
- Organizer
  第57回日本薬学会関東支部大会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24590667
[Presentation] アルギン酸による重金属吸着作用の解析
- Author(s)
  荻原琢男，加藤多佳子，井戸田陽子，矢野健太郎，荒川大，安竹良礼，宮島千尋，笠原文善
- Organizer
  第42回日本毒性学会学術年会
- Place of Presentation
  金沢
- Year and Date
  2015-06-29 – 2015-07-01
- Data Source
  KAKENHI-PROJECT-25560062
[Presentation] ヒト癌細胞のP-gp輸送活性に対するradixinの関与
- Author(s)
  川端秀明, 矢野健太郎, 大塚杏磨, 金井祐樹, 伴野拓巳, 荒川大, 荻原琢男
- Organizer
  第9回トランスポーター研究会年会
- Place of Presentation
  名古屋
- Year and Date
  2014-06-14 – 2014-06-15
- Data Source
  KAKENHI-PROJECT-24590667
[Presentation] 薬物の苦味によるP-糖タンパクの基質認識性の予測
- Author(s)
  三田鈴音, 矢野健太郎, 荒川大, 原口珠実, 吉田都, 内田享弘, 荻原琢男
- Organizer
  日本薬剤学会第29回年会
- Place of Presentation
  大宮
- Year and Date
  2014-05-20 – 2014-05-22
- Data Source
  KAKENHI-PROJECT-24590667
[Presentation] アルギン酸による重金属の吸収抑制および排泄促進作用とそのメカニズムの検討
- Author(s)
  荻原琢男, 井戸田陽子, 木暮悠美, 原田瞳, 河合妙子, 矢野健太郎, 柿沼千早, 宮島千尋, 笠原文善
- Organizer
  第41回日本毒性学会学術年会
- Place of Presentation
  神戸
- Year and Date
  2014-07-02 – 2014-07-04
- Data Source
  KAKENHI-PROJECT-25560062
[Presentation] Effects of Calcium Alginate on Lowering Cholesterol in Rats
- Author(s)
  T. Yasutake, Y. Idota, Y. Kogure, T. Kato, K. Yano, H. Arakawa, C. Kakinuma, C. Miyajima, F. Kasahara, S. Kobayashi, T. Ogihara
- Organizer
  第2回薬食国際カンファレンス
- Place of Presentation
  静岡
- Year and Date
  2014-11-05 – 2014-11-06
- Data Source
  KAKENHI-PROJECT-25560062

1. MORIMOTO Kaori (90401009)

# of Collaborated Projects : 5results

# of Collaborated Products : 20results
2. KENTARO Yano (40644290)

# of Collaborated Projects : 5results

# of Collaborated Products : 46results
3. IDOTA Yoko (90629594)

# of Collaborated Projects : 3results

# of Collaborated Products : 29results
4. TAMAI Ikumi (20155237)

# of Collaborated Projects : 2results

# of Collaborated Products : 3results
5. KANO Takashi (70509257)

# of Collaborated Projects : 1results

# of Collaborated Products : 3results
6. MASAHIRO Kajita (40591871)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
7. TOMITA Mikio (60207610)

# of Collaborated Projects : 1results

# of Collaborated Products : 3results
8. ZHANG Pengyao (80643311)

# of Collaborated Projects : 1results

# of Collaborated Products : 1results
9. YAMASHITA Fumiyoshi

# of Collaborated Projects : 0results

# of Collaborated Products : 2results
10. YANO Ikuko

# of Collaborated Projects : 0results

# of Collaborated Products : 1results
11. 小林彰子

# of Collaborated Projects : 0results

# of Collaborated Products : 2results
12. 大森慎也

# of Collaborated Projects : 0results

# of Collaborated Products : 1results

OGIHARA Takuo 荻原 琢男

Research Projects

Research Products

Co-Researchers

Mechanism and clinical prediction of drug resistance associated with epithelial mesenchymal transition of lung cancerPrincipal InvestigatorOngoing

Principal Investigator

Project Period (FY)

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膜裏打ちタンパクの制御による臓器特異的ながん多剤耐性の非働化Principal InvestigatorOngoing

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Evaluation of the intestinal secretion of indoxyl sulfate as a possible compensative excretion pathway in chronic kidney disease

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Study of alginate's effect and mechanism, enhancing excretion and reducing absorption of strontium and cesium.

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The construction of a means to overcome cancerous multidrug resistance by mediating the post-translational regulators of drug-efflux transportersPrincipal Investigator

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Effect of Food on the Intestinal PEPT1-mediated Drug Absorption

Principal Investigator

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The mechanism and its inter-individual variability of the Blood-Brain Barrier penetration of anti-influenza drug, oseltamivir

Principal Investigator

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[Book] 実践製剤学－そしてその基礎となる物理薬剤学2015

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[Book] 実践 製剤学 そしてその基盤となる物理薬剤学2015

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[Book] 2 試料の調製および分析法, 薬剤学実験法必携マニュアル Pharmaceutical Scientistのために Ⅱ 生物薬剤学2014

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[Book] 第1章 総論, わかりやすい生物薬剤学 第5版2014

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[Book] 薬剤学実験法必携マニュアル2014

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[Book] 2 試料の調製および分析法, 薬剤学実験法必携マニュアル Pharmaceutical Scientistのために Ⅱ 生物薬剤学2014

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[Book] 薬剤学実験法必携マニュアル 生物薬剤学2013

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OGIHARA Takuo 荻原琢男

[Book] 実践　製剤学　そしてその基盤となる物理薬剤学2015

[Book] 第1章総論, わかりやすい生物薬剤学第5版2014

[Book] 薬剤学実験法必携マニュアル　生物薬剤学2013