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Arakawa Hiroshi  荒川 大

ORCIDConnect your ORCID iD *help
Researcher Number 40709028
Other IDs
Affiliation (Current) 2022: 金沢大学, 薬学系, 准教授
Affiliation (based on the past Project Information) *help 2020 – 2022: 金沢大学, 薬学系, 准教授
2016 – 2018: 金沢大学, 薬学系, 助教
2017: 金沢大学, 医薬保健研究域薬学系, 助教
Review Section/Research Field
Principal Investigator
Physical pharmacy / Basic Section 47060:Clinical pharmacy-related / Medium-sized Section 47:Pharmaceutical sciences and related fields
Except Principal Investigator
Medical pharmacy / Transformative Research Areas, Section (II) / Basic Section 47060:Clinical pharmacy-related
Keywords
Principal Investigator
トランスポーター / MRI / がん / 診断 / 画像診断 / ペプチドトランスポーター / 尿中排泄率 / 簡易毒性試験 / 薬学 / 血液脳関門 … More / 薬物トランスポーター / 脳移行性 / スクリーニング / OCTN2 / アリピプラゾール / ノックアウト / sgRNAスクリーニング / 薬物脳移行 / 慢性腎毒性 / 尿毒症物質 / トリガータンパク質 … More
Except Principal Investigator
トランスポーター / 臓器間相互作用 / P-gp / BCRP / MRPs / 網羅的な阻害 / 足場タンパク / がん組織 / 排出系トランスポーター / 多剤耐性 / MRPs / P-糖たんぱく / MRP / 腎臓がん / 消化管がん / 組織差 / P-糖タンパク / radixin / 臓器チップ / 灌流共培養 / マイクロフィジオロジカルシステム / 小腸 / 肝臓 / 腎臓 / 三次元培養 / 相互作用 / 尿酸 / 高尿酸血症 / NDFIP1 / CD38 / 痛風 / 受容体 / センサー / 脂質代謝 / 薬物動態 Less
  • Research Projects

    (6 results)
  • Research Products

    (20 results)
  • Co-Researchers

    (14 People)
  •  CKD予防・治療手法の提唱を目指した尿毒症物質の腎毒性トリガータンパク質の同定Principal Investigator

    • Principal Investigator
      荒川 大
    • Project Period (FY)
      2022 – 2023
    • Research Category
      Grant-in-Aid for Challenging Research (Exploratory)
    • Review Section
      Medium-sized Section 47:Pharmaceutical sciences and related fields
    • Research Institution
      Kanazawa University
  •  血清尿酸値を感受する尿酸センサーの同定と生理作用

    • Principal Investigator
      玉井 郁巳
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 47060:Clinical pharmacy-related
    • Research Institution
      Kanazawa University
  •  Crosstalks between different organs cultured in OrganS on-a-chip

    • Principal Investigator
      酒井 康行
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Transformative Research Areas (B)
    • Review Section
      Transformative Research Areas, Section (II)
    • Research Institution
      The University of Tokyo
  •  Identification of blood-brain barrier transporters using sgRNA libraryPrincipal Investigator

    • Principal Investigator
      Arakawa Hiroshi
    • Project Period (FY)
      2020 – 2021
    • Research Category
      Grant-in-Aid for Early-Career Scientists
    • Review Section
      Basic Section 47060:Clinical pharmacy-related
    • Research Institution
      Kanazawa University
  •  Drug discovery for peptide transporter targeting cancer diagnostic probe using magnetic Resonance ImagingPrincipal Investigator

    • Principal Investigator
      Arakawa Hiroshi
    • Project Period (FY)
      2016 – 2018
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Physical pharmacy
    • Research Institution
      Kanazawa University
  •  Organ-specific inactivation of cancer multidrug resistance by regulating membrane scaffold proteins

    • Principal Investigator
      Ogihara Takuo
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Medical pharmacy
    • Research Institution
      Takasaki University of Health and Welfare

All 2022 2021 2020 2016 2015

All Journal Article Presentation

  • [Journal Article] Characterization of Aripiprazole Uptake Transporter in the Blood-Brain Barrier Model hCMEC/D3 Cells by Targeted siRNA Screening2022

    • Author(s)
      Moeno Kadoguchi, Hiroshi Arakawa, Ryokichi Honda, Kazuki Hotta, Yoshiyuki Shirasaka, Yoshiharu Deguchi, Ikumi Tamai
    • Journal Title

      Pharmaceutical Research

      Volume: -

    • DOI

      10.1007/s11095-022-03223-z

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20K16039
  • [Journal Article] Multi‐omics analysis of hiPSCs‐derived HLCs matured on‐chip revealed patterns typical of liver regeneration2021

    • Author(s)
      Danoy M, Tauran Y, Poulain S, Jellali R, Bruce J, Leduc M, Gall M, Koui Y, Arakawa H, Gilard F, Kato Y, Kido T, Miyajima A, Sakai Y, Leclerc E
    • Journal Title

      Biotechnology and Bioengineering

      Volume: 118 Pages: 3716-3732

    • DOI

      10.1002/bit.27667

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-20H05745, KAKENHI-PROJECT-16H06328, KAKENHI-PROJECT-21H02710
  • [Journal Article] CD38 activation by monosodium urate crystals contributes to inflammatory response in macrophages.2021

    • Author(s)
      Wen S, Arakawa H, Tamai I
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 581 Pages: 6-11

    • DOI

      10.1016/j.bbrc.2021.10.010

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PLANNED-20H05745, KAKENHI-PROJECT-21H02641
  • [Journal Article] Coculture with hiPS-derived intestinal cells enhanced human hepatocyte functions in a pneumatic-pressure-driven two-organ microphysiological system2021

    • Author(s)
      Shinohara Marie、Arakawa Hiroshi、Oda Yuuichi、Shiraki Nobuaki、Sugiura Shinji、Nishiuchi Takumi、Satoh Taku、Iino Keita、Leo Sylvia、Kato Yusuke、Araya Karin、Kawanishi Takumi、Nakatsuji Tomoki、Mitsuta Manami、Inamura Kosuke、Goto Tomomi、Shinha Kenta、Nihei Wataru、Komori Kikuo、Sakai Yasuyuki、Kimura Hiroshi
    • Journal Title

      Sci. Rep.

      Volume: 11 Pages: 5437-5437

    • DOI

      10.1038/s41598-021-84861-y

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18H01849, KAKENHI-PLANNED-20H05745, KAKENHI-PROJECT-18H02154
  • [Journal Article] Possible interaction of quinolone antibiotics with peptide transporter 1 in oral absorption of peptide-mimetic drugs.2016

    • Author(s)
      Arakawa H, Kamioka H, Kanagawa M, Hatano Y, Idota Y, Yano K, Morimoto K, Ogihara T.
    • Journal Title

      Biopharm Drug Dispos.

      Volume: 37 Pages: 39-45

    • DOI

      10.1002/bdd.1999

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15K08078
  • [Journal Article] Different regulation of P-glycoprotein function between Caco-2 and Caki-1 cells by ezrin, radixin and moesin proteins.2016

    • Author(s)
      Yano K, Otsuka K, Kato Y, Kawabata H, Ohmori S, Arakawa H, Ogihara T.
    • Journal Title

      J. Pharm. Pharmacol.

      Volume: 68 Pages: 361-367

    • DOI

      10.1111/jphp.12525

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-15K08078, KAKENHI-PROJECT-15K19014
  • [Journal Article] Interaction of Peptide Transporter 1 With d-Glucose and l-Glutamic Acid; Possible Involvement of Taste Receptors.2016

    • Author(s)
      Arakawa H, Ohmachi T, Ichiba K, Kamioka H, Tomono T, Kanagawa M, Idota Y, Hatano Y, Yano K, Morimoto K, Ogihara T.
    • Journal Title

      J. Pharm. Sci.

      Volume: 105 Pages: 339-342

    • DOI

      10.1016/j.xphs.2015.11.024

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15K08078, KAKENHI-PROJECT-25560062
  • [Journal Article] Recommended Daily Dose of Sesame Lignans Has No Influence on Oral Absorption of P-Glycoprotein Substrates in Rats2015

    • Author(s)
      Tomono T, Otsuka K, Yano K, Kanagawa M, Arakawa H, Ogihara T.
    • Journal Title

      Biol. Pharm. Bull.

      Volume: 38 Issue: 12 Pages: 1960-1963

    • DOI

      10.1248/bpb.b15-00392

    • NAID

      130005112643

    • ISSN
      0918-6158, 1347-5215
    • Language
      English
    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-15K08078
  • [Presentation] CD38 activation contributes to gouty inflammation in vitro2022

    • Author(s)
      Wen S, Arakawa S, Tamai I.
    • Organizer
      日本痛風・尿酸核酸学会総会
    • Data Source
      KAKENHI-PROJECT-21H02641
  • [Presentation] siRNAスクリーニング法を用いたpyrilamineの血液脳関門薬物輸送体の探索2021

    • Author(s)
      角口萌乃、荒川大、玉井郁巳
    • Organizer
      日本薬学会北陸支部第133回例会
    • Data Source
      KAKENHI-PROJECT-20K16039
  • [Presentation] 腸肝連結型MPSを用いた薬物代謝と臓器間相互作用の解析2021

    • Author(s)
      荒川大、河西巧、加藤将夫
    • Organizer
      CBI学会2020プログラム
    • Invited
    • Data Source
      KAKENHI-PLANNED-20H05745
  • [Presentation] 肝小腸連結型MPSで見えてきた薬物代謝における臓器間相互作用2020

    • Author(s)
      荒川大、河西巧、加藤将夫
    • Organizer
      第47回日本毒性学会学術年会
    • Data Source
      KAKENHI-PLANNED-20H05745
  • [Presentation] 腸肝連結型microphysiological systemを用いた薬物動態の臓器連関研究2020

    • Author(s)
      荒川大、河西巧、加藤将夫
    • Organizer
      第20回日本再生医療学会総会
    • Invited
    • Data Source
      KAKENHI-PLANNED-20H05745
  • [Presentation] ヒト腎臓がん細胞のP-gp およびMRPs 輸送機能における足場タンパクの関与2016

    • Author(s)
      加藤 木綿子、矢野 健太郎、井戸田 陽子、荒川 大、荻原 琢男
    • Organizer
      日本薬学会第136年会
    • Place of Presentation
      横浜
    • Year and Date
      2016-03-26
    • Data Source
      KAKENHI-PROJECT-15K08078
  • [Presentation] 日米EU3局の薬物相互作用ガイドラインの概要まとめと比較2015

    • Author(s)
      山田 浩行、荒川 大、楠本 久美子、小島 肇、荻原 琢男
    • Organizer
      第59回日本薬学会関東支部大会
    • Place of Presentation
      船橋
    • Year and Date
      2015-09-12
    • Data Source
      KAKENHI-PROJECT-15K08078
  • [Presentation] がん組織におけるERMタンパクによるP-gp輸送機能の調節機構2015

    • Author(s)
      加藤木綿子、矢野健太郎、大塚杏磨、荒川大、荻原琢男
    • Organizer
      第8回トランスポーター研究会
    • Place of Presentation
      慶応義塾大学薬学部
    • Year and Date
      2015-06-20
    • Data Source
      KAKENHI-PROJECT-15K08078
  • [Presentation] 基質薬物とキノロン系抗菌薬との消化管吸収過程における相互作用2015

    • Author(s)
      荻原 琢男、上岡 宏紀、金川 雅彦、井戸田 陽子、矢野 健太郎、森本 かおり、荒川 大
    • Organizer
      第37回生体膜と薬物の相互作用シンポジウム
    • Place of Presentation
      熊本
    • Year and Date
      2015-11-19
    • Data Source
      KAKENHI-PROJECT-15K08078
  • [Presentation] Transcriptional factor Snail activates P-glycoprotein function in lung adenocarcinoma cells2015

    • Author(s)
      伴野 拓巳、矢野 健太郎、荒川 大、荻原 琢男
    • Organizer
      日本薬物動態学会第30年会
    • Place of Presentation
      東京 タワーホール船堀
    • Year and Date
      2015-11-12
    • Data Source
      KAKENHI-PROJECT-15K08078
  • [Presentation] Utility of three-dimensional culture of human hepatocyte as a tool of drug metabolizing enzyme induction2015

    • Author(s)
      荒川 大、上岡 宏紀、井戸田 陽子、矢野 健太郎、荻原 琢男
    • Organizer
      日本薬物動態学会第30年会
    • Place of Presentation
      東京 タワーホール船堀
    • Year and Date
      2015-11-12
    • Data Source
      KAKENHI-PROJECT-15K08078
  • [Presentation] Tissue-selective regulation of P-gp function in cancers by ERM proteins2015

    • Author(s)
      矢野 健太郎、大塚 杏磨、加藤 木綿子、井戸田 陽子、荒川 大、荻原 琢男
    • Organizer
      日本薬物動態学会第30年会
    • Place of Presentation
      東京 タワーホール船堀
    • Year and Date
      2015-11-12
    • Data Source
      KAKENHI-PROJECT-15K08078
  • 1.  Ogihara Takuo (80448886)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 11 results
  • 2.  Idota Yoko (90629594)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 6 results
  • 3.  矢野 健太郎 (40644290)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 10 results
  • 4.  酒井 康行 (00235128)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 5.  杉浦 慎治 (10399496)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 6.  玉井 郁巳 (20155237)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 7.  若山 友彦 (70305100)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  藤田 光 (40782850)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 9.  KOMORI Kikuo
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 10.  SHIRAKI Nobuaki
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 11.  OHMORI Shinya
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 12.  PLESSY Charles
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 13.  木戸 丈友
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 14.  木村 啓志
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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