Arakawa Hiroshi 荒川大

Researcher Number	40709028
Other IDs
Affiliation (Current)	2023: 金沢大学, 薬学系, 准教授
Affiliation (based on the past Project Information) *help	2020 – 2023: 金沢大学, 薬学系, 准教授 2016 – 2018: 金沢大学, 薬学系, 助教 2017: 金沢大学, 医薬保健研究域薬学系, 助教
Review Section/Research Field	Principal Investigator Basic Section 47060:Clinical pharmacy-related / Physical pharmacy / Medium-sized Section 47:Pharmaceutical sciences and related fields Except Principal Investigator Medical pharmacy / Transformative Research Areas, Section (II) / Basic Section 47060:Clinical pharmacy-related
Keywords	Principal Investigator トランスポーター / MRI / がん / 診断 / 画像診断 / ペプチドトランスポーター / 尿中排泄率 / 簡易毒性試験 / 薬学 / 血液脳関門 … More / 薬物トランスポーター / 脳移行性 / スクリーニング / OCTN2 / アリピプラゾール / ノックアウト / sgRNAスクリーニング / 薬物脳移行 / 慢性腎毒性 / 尿毒症物質 / トリガータンパク質 … More Except Principal Investigator トランスポーター / 臓器間相互作用 / P-gp / BCRP / MRPｓ / 網羅的な阻害 / 足場タンパク / がん組織 / 排出系トランスポーター / 多剤耐性 / MRPs / P-糖たんぱく / MRP / 腎臓がん / 消化管がん / 組織差 / P-糖タンパク / radixin / 臓器チップ / 灌流共培養 / マイクロフィジオロジカルシステム / 小腸 / 肝臓 / 腎臓 / 三次元培養 / 相互作用 / 尿酸 / 高尿酸血症 / NDFIP1 / CD38 / 痛風 / 受容体 / センサー / 脂質代謝 / 薬物動態 Less

薬物代謝反応に及ぼす小胞体膜輸送体の役割解明Principal Investigator
- Principal Investigator
  
  荒川大
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Kanazawa University
CKD予防・治療手法の提唱を目指した尿毒症物質の腎毒性トリガータンパク質の同定Principal Investigator
- Principal Investigator
  
  荒川大
- Project Period (FY)
  2022 – 2023
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 47:Pharmaceutical sciences and related fields
- Research Institution
  Kanazawa University
血清尿酸値を感受する尿酸センサーの同定と生理作用
- Principal Investigator
  
  玉井郁巳
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Kanazawa University
Crosstalks between different organs cultured in OrganS on-a-chip
- Principal Investigator
  
  酒井康行
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (B)
- Review Section
  
  Transformative Research Areas, Section (II)
- Research Institution
  The University of Tokyo
Identification of blood-brain barrier transporters using sgRNA libraryPrincipal Investigator
- Principal Investigator
  
  Arakawa Hiroshi
- Project Period (FY)
  2020 – 2021
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Kanazawa University
Drug discovery for peptide transporter targeting cancer diagnostic probe using magnetic Resonance ImagingPrincipal Investigator
- Principal Investigator
  
  Arakawa Hiroshi
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Physical pharmacy
- Research Institution
  Kanazawa University
Organ-specific inactivation of cancer multidrug resistance by regulating membrane scaffold proteins
- Principal Investigator
  
  Ogihara Takuo
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  Takasaki University of Health and Welfare

All 2022 2021 2020 2016 2015

All Journal Article Presentation

[Journal Article] Characterization of Aripiprazole Uptake Transporter in the Blood-Brain Barrier Model hCMEC/D3 Cells by Targeted siRNA Screening2022
- Author(s)
  Moeno Kadoguchi, Hiroshi Arakawa, Ryokichi Honda, Kazuki Hotta, Yoshiyuki Shirasaka, Yoshiharu Deguchi, Ikumi Tamai
- Journal Title
  
  Pharmaceutical Research
  
  Volume: -
- DOI
  10.1007/s11095-022-03223-z
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K16039
[Journal Article] Multi‐omics analysis of hiPSCs‐derived HLCs matured on‐chip revealed patterns typical of liver regeneration2021
- Author(s)
  Danoy M, Tauran Y, Poulain S, Jellali R, Bruce J, Leduc M, Gall M, Koui Y, Arakawa H, Gilard F, Kato Y, Kido T, Miyajima A, Sakai Y, Leclerc E
- Journal Title
  
  Biotechnology and Bioengineering
  
  Volume: 118 Pages: 3716-3732
- DOI
  10.1002/bit.27667
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-20H05745, KAKENHI-PROJECT-16H06328, KAKENHI-PROJECT-21H02710
[Journal Article] CD38 activation by monosodium urate crystals contributes to inflammatory response in macrophages.2021
- Author(s)
  Wen S, Arakawa H, Tamai I
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 581 Pages: 6-11
- DOI
  10.1016/j.bbrc.2021.10.010
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-20H05745, KAKENHI-PROJECT-21H02641
[Journal Article] Coculture with hiPS-derived intestinal cells enhanced human hepatocyte functions in a pneumatic-pressure-driven two-organ microphysiological system2021
- Author(s)
  Shinohara Marie、Arakawa Hiroshi、Oda Yuuichi、Shiraki Nobuaki、Sugiura Shinji、Nishiuchi Takumi、Satoh Taku、Iino Keita、Leo Sylvia、Kato Yusuke、Araya Karin、Kawanishi Takumi、Nakatsuji Tomoki、Mitsuta Manami、Inamura Kosuke、Goto Tomomi、Shinha Kenta、Nihei Wataru、Komori Kikuo、Sakai Yasuyuki、Kimura Hiroshi
- Journal Title
  
  Sci. Rep.
  
  Volume: 11 Pages: 5437-5437
- DOI
  10.1038/s41598-021-84861-y
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H01849, KAKENHI-PLANNED-20H05745, KAKENHI-PROJECT-18H02154
[Journal Article] Possible interaction of quinolone antibiotics with peptide transporter 1 in oral absorption of peptide-mimetic drugs.2016
- Author(s)
  Arakawa H, Kamioka H, Kanagawa M, Hatano Y, Idota Y, Yano K, Morimoto K, Ogihara T.
- Journal Title
  
  Biopharm Drug Dispos.
  
  Volume: 37 Pages: 39-45
- DOI
  10.1002/bdd.1999
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K08078
[Journal Article] Different regulation of P-glycoprotein function between Caco-2 and Caki-1 cells by ezrin, radixin and moesin proteins.2016
- Author(s)
  Yano K, Otsuka K, Kato Y, Kawabata H, Ohmori S, Arakawa H, Ogihara T.
- Journal Title
  
  J. Pharm. Pharmacol.
  
  Volume: 68 Pages: 361-367
- DOI
  10.1111/jphp.12525
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K08078, KAKENHI-PROJECT-15K19014
[Journal Article] Interaction of Peptide Transporter 1 With d-Glucose and l-Glutamic Acid; Possible Involvement of Taste Receptors.2016
- Author(s)
  Arakawa H, Ohmachi T, Ichiba K, Kamioka H, Tomono T, Kanagawa M, Idota Y, Hatano Y, Yano K, Morimoto K, Ogihara T.
- Journal Title
  
  J. Pharm. Sci.
  
  Volume: 105 Pages: 339-342
- DOI
  10.1016/j.xphs.2015.11.024
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K08078, KAKENHI-PROJECT-25560062
[Journal Article] Recommended Daily Dose of Sesame Lignans Has No Influence on Oral Absorption of P-Glycoprotein Substrates in Rats2015
- Author(s)
  Tomono T, Otsuka K, Yano K, Kanagawa M, Arakawa H, Ogihara T.
- Journal Title
  
  Biol. Pharm. Bull.
  
  Volume: 38 Issue: 12 Pages: 1960-1963
- DOI
  10.1248/bpb.b15-00392
- NAID
  130005112643
- ISSN
  0918-6158, 1347-5215
- Language
  English
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K08078
[Presentation] CD38 activation contributes to gouty inflammation in vitro2022
- Author(s)
  Wen S, Arakawa S, Tamai I.
- Organizer
  日本痛風・尿酸核酸学会総会
- Data Source
  KAKENHI-PROJECT-21H02641
[Presentation] siRNAスクリーニング法を用いたpyrilamineの血液脳関門薬物輸送体の探索2021
- Author(s)
  角口萌乃、荒川大、玉井郁巳
- Organizer
  日本薬学会北陸支部第133回例会
- Data Source
  KAKENHI-PROJECT-20K16039
[Presentation] 腸肝連結型MPSを用いた薬物代謝と臓器間相互作用の解析2021
- Author(s)
  荒川大、河西巧、加藤将夫
- Organizer
  CBI学会2020プログラム
- Invited
- Data Source
  KAKENHI-PLANNED-20H05745
[Presentation] 肝小腸連結型MPSで見えてきた薬物代謝における臓器間相互作用2020
- Author(s)
  荒川大、河西巧、加藤将夫
- Organizer
  第47回日本毒性学会学術年会
- Data Source
  KAKENHI-PLANNED-20H05745
[Presentation] 腸肝連結型microphysiological systemを用いた薬物動態の臓器連関研究2020
- Author(s)
  荒川大、河西巧、加藤将夫
- Organizer
  第20回日本再生医療学会総会
- Invited
- Data Source
  KAKENHI-PLANNED-20H05745
[Presentation] ヒト腎臓がん細胞のP-gp およびMRPs 輸送機能における足場タンパクの関与2016
- Author(s)
  加藤木綿子、矢野健太郎、井戸田陽子、荒川大、荻原琢男
- Organizer
  日本薬学会第136年会
- Place of Presentation
  横浜
- Year and Date
  2016-03-26
- Data Source
  KAKENHI-PROJECT-15K08078
[Presentation] 日米EU3局の薬物相互作用ガイドラインの概要まとめと比較2015
- Author(s)
  山田　浩行、荒川　大、楠本　久美子、小島　肇、荻原　琢男
- Organizer
  第59回日本薬学会関東支部大会
- Place of Presentation
  船橋
- Year and Date
  2015-09-12
- Data Source
  KAKENHI-PROJECT-15K08078
[Presentation] がん組織におけるERMタンパクによるP-gp輸送機能の調節機構2015
- Author(s)
  加藤木綿子、矢野健太郎、大塚杏磨、荒川大、荻原琢男
- Organizer
  第8回トランスポーター研究会
- Place of Presentation
  慶応義塾大学薬学部
- Year and Date
  2015-06-20
- Data Source
  KAKENHI-PROJECT-15K08078
[Presentation] 基質薬物とキノロン系抗菌薬との消化管吸収過程における相互作用2015
- Author(s)
  荻原　琢男、上岡　宏紀、金川　雅彦、井戸田　陽子、矢野　健太郎、森本　かおり、荒川　大
- Organizer
  第37回生体膜と薬物の相互作用シンポジウム
- Place of Presentation
  熊本
- Year and Date
  2015-11-19
- Data Source
  KAKENHI-PROJECT-15K08078
[Presentation] Transcriptional factor Snail activates P-glycoprotein function in lung adenocarcinoma cells2015
- Author(s)
  伴野　拓巳、矢野　健太郎、荒川　大、荻原　琢男
- Organizer
  日本薬物動態学会第30年会
- Place of Presentation
  東京　タワーホール船堀
- Year and Date
  2015-11-12
- Data Source
  KAKENHI-PROJECT-15K08078
[Presentation] Utility of three-dimensional culture of human hepatocyte as a tool of drug metabolizing enzyme induction2015
- Author(s)
  荒川　大、上岡　宏紀、井戸田　陽子、矢野　健太郎、荻原　琢男
- Organizer
  日本薬物動態学会第30年会
- Place of Presentation
  東京　タワーホール船堀
- Year and Date
  2015-11-12
- Data Source
  KAKENHI-PROJECT-15K08078
[Presentation] Tissue-selective regulation of P-gp function in cancers by ERM proteins2015
- Author(s)
  矢野　健太郎、大塚　杏磨、加藤　木綿子、井戸田　陽子、荒川　大、荻原　琢男
- Organizer
  日本薬物動態学会第30年会
- Place of Presentation
  東京　タワーホール船堀
- Year and Date
  2015-11-12
- Data Source
  KAKENHI-PROJECT-15K08078

1. Ogihara Takuo (80448886)

# of Collaborated Projects: 2 results

# of Collaborated Products: 11 results
2. Idota Yoko (90629594)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
3. 矢野健太郎 (40644290)

# of Collaborated Projects: 1 results

# of Collaborated Products: 10 results
4. 酒井康行 (00235128)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
5. 杉浦慎治 (10399496)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
6. 玉井郁巳 (20155237)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
7. 若山友彦 (70305100)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 藤田光 (40782850)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. KOMORI Kikuo

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. SHIRAKI Nobuaki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. OHMORI Shinya

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. PLESSY Charles

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 木戸丈友

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 木村啓志

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Arakawa Hiroshi 荒川 大

Research Projects

Research Products

Co-Researchers

薬物代謝反応に及ぼす小胞体膜輸送体の役割解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

CKD予防・治療手法の提唱を目指した尿毒症物質の腎毒性トリガータンパク質の同定Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

血清尿酸値を感受する尿酸センサーの同定と生理作用

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Crosstalks between different organs cultured in OrganS on-a-chip

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Identification of blood-brain barrier transporters using sgRNA libraryPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Drug discovery for peptide transporter targeting cancer diagnostic probe using magnetic Resonance ImagingPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Organ-specific inactivation of cancer multidrug resistance by regulating membrane scaffold proteins

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Characterization of Aripiprazole Uptake Transporter in the Blood-Brain Barrier Model hCMEC/D3 Cells by Targeted siRNA Screening2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Multi‐omics analysis of hiPSCs‐derived HLCs matured on‐chip revealed patterns typical of liver regeneration2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] CD38 activation by monosodium urate crystals contributes to inflammatory response in macrophages.2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Coculture with hiPS-derived intestinal cells enhanced human hepatocyte functions in a pneumatic-pressure-driven two-organ microphysiological system2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Possible interaction of quinolone antibiotics with peptide transporter 1 in oral absorption of peptide-mimetic drugs.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Different regulation of P-glycoprotein function between Caco-2 and Caki-1 cells by ezrin, radixin and moesin proteins.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Interaction of Peptide Transporter 1 With d-Glucose and l-Glutamic Acid; Possible Involvement of Taste Receptors.2016

Author(s)

Journal Title

DOI

Arakawa Hiroshi 荒川大