NARUSHIMA SEIKO 成島聖子

… Alternative Names

成島聖子ナルシマセイコ

Narushima Seiko 成島聖子

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Researcher Number	80578336
Affiliation (Current)	2025: 国立研究開発法人理化学研究所, 生命医科学研究センター, 上級研究員
Affiliation (based on the past Project Information) *help	2022 – 2023: 国立研究開発法人理化学研究所, 生命医科学研究センター, 上級研究員 2020: 国立研究開発法人理化学研究所, 生命医科学研究センター, 上級研究員 2018: 国立研究開発法人理化学研究所, 生命医科学研究センター, 副チームリーダー 2016 – 2017: 国立研究開発法人理化学研究所, 統合生命医科学研究センター, 副チームリーダー 2015: 国立研究開発法人理化学研究所, 統合生命医科学研究センター, 研究員 2014: 独立行政法人理化学研究所, 統合生命医科学研究センター, 研究員
Review Section/Research Field	Principal Investigator Basic Section 49030:Experimental pathology-related / Integrative animal science / Experimental pathology Except Principal Investigator Basic Section 53010:Gastroenterology-related / Medium-sized Section 52:General internal medicine and related fields / Basic Section 54040:Metabolism and endocrinology-related / Biological Sciences
Keywords	Principal Investigator 胆汁酸 / 腸内細菌 / ノトバイオートマウス / ノトバイオート / 胆汁酸代謝 / モデル動物 / 大腸腫瘍 / 大腸発癌 / マウスモデル Except Principal Investigator 腸内細菌叢 … More / 腸内細菌 / 小児 / 脂肪酸-胆汁酸エステル / 潰瘍性大腸炎 / メタトランスクリプトーム解析 / プロテオーム解析 / メタゲノム解析 / 腸内細菌トランスオミクス解析 / トランスクリプトーム / プロテオーム / メタゲノム / 脂質エステル体 / 胆汁酸 / LC/MS / IL-6 / 胆汁酸脂肪酸エステル体 / 便中胆汁酸 / がん / 多剤耐性菌 / 常在細 / 百寿 / 抗生物質耐性菌 / 代謝疾患 / 大腸がん / ワクチン / 抗生物質耐性 / 常在細菌 Less

The translational research for pediatric diseases based on gut bacterial transomics analysis
- Principal Investigator
  
  藤代準
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Challenging Research (Pioneering)
- Review Section
  
  Medium-sized Section 52:General internal medicine and related fields
- Research Institution
  The University of Tokyo
腸内細菌の協調作用による二次胆汁酸生成の探索と宿主健康に及ぼす影響の解析Principal Investigator
- Principal Investigator
  
  成島聖子
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49030:Experimental pathology-related
- Research Institution
  Institute of Physical and Chemical Research
Investigation of the Functional Mechanisms of Local Intestinal Microbiome and Fatty Acid-Bile Acid Esters in the Pathogenesis of Ulcerative Colitis.
- Principal Investigator
  
  神保圭佑
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Juntendo University
胆汁酸・脂質エステル体産生に寄与する腸内細菌叢同定と生理学的作用機序の探索
- Principal Investigator
  
  鈴木光幸
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54040:Metabolism and endocrinology-related
- Research Institution
  Juntendo University
Unraveling the principles of microbiota function for rationally-designed biotherapeutics
- Principal Investigator
  
  本田賢也
- Project Period (FY)
  2020 – 2025
- Research Category
  
  Grant-in-Aid for Specially Promoted Research
- Review Section
  
  Biological Sciences
- Research Institution
  Keio University
Bile acid metabolism by intestinal microbiotaPrincipal Investigator
- Principal Investigator
  
  Narushima Seiko
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Integrative animal science
- Research Institution
  Institute of Physical and Chemical Research
Effect of Intestinal microbiota on inflammation induced colon cancerPrincipal Investigator
- Principal Investigator
  
  Narushima Seiko
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Experimental pathology
- Research Institution
  Institute of Physical and Chemical Research

All 2023 2022 2021 2019 2018 2015

All Journal Article Presentation

[Journal Article] Characterization of long-chain fatty acid-linked bile acids: a major conjugation form of 3β-hydroxy bile acids in feces2022
- Author(s)
  Takei H, Narushima S, Suzuki M, Kakiyama G, Sasaki T, Murai T, Yamashro Y, Nittono H.
- Journal Title
  
  J Lipid Res
  
  Volume: 10 Issue: 10 Pages: 100275-100275
- DOI
  10.1016/j.jlr.2022.100275
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K08662
[Journal Article] Novel bile acid biosynthetic pathways are enriched in the microbiome of centenarians2021
- Author(s)
  Yuko Sato, Koji Atarashi, Damian R. Plichta, Yasumichi Arai, Satoshi Sasajima, SM. Kearney, Kozue Takeshita, AN. Skelly, Youxian Li, Takeshi Tanoue, Seiko Narushima, DR. Littman, MA. Fischbach, Y Uwamino, T Inoue, A Honda, Masahira Hattori, Tsuyoshi Murai, Ramnik J. Xavier, Nobuyoshi Hirose, Kenya Honda, et al.
- Journal Title
  
  Nature
  
  Volume: 599 Issue: 7885 Pages: 458-464
- DOI
  10.1038/s41586-021-03832-5
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H05627, KAKENHI-PROJECT-20H00535, KAKENHI-PROJECT-18H03055, KAKENHI-PROJECT-21K08584, KAKENHI-PROJECT-21K18270
[Journal Article] Endocytosis of commensal antigens by intestinal epithelial cells regulates mucosal T cell homeostasis2019
- Author(s)
  Ladinsky MS、Araujo LP、Zhang X、Veltri J、Galan-Diez M、Soualhi S、Lee C、Irie K、Pinker EY、Narushima S、Bandyopadhyay S、Nagayama M、Elhenawy W、Coombes BK、Ferraris RP、Honda K、Iliev ID、Gao N、Bjorkman PJ、Ivanov II.
- Journal Title
  
  Science
  
  Volume: 363 Issue: 6431
- DOI
  10.1126/science.aat4042
- Data Source
  KAKENHI-PROJECT-16K08091
[Journal Article] A defined commensal consortium elicits CD8 T cells and anti-cancer immunity2019
- Author(s)
  T.Tanoue, S.Morita, D.R.Plichta, A.N.Skelly, W.Suda, Y.Sugiura, S.Narushima, H.Vlamakis, I.Motoo, K.Sugita, A.Shiota, K.Takeshita, K.Yasuma, D.Riethmacher, T.Kaisho, J.M.Norman, D.Mucida, M.Suematsu, T.Yaguchi, V.Bucci, T.Inoue, Y.Kawakami, B.Olle, B.Roberts, M.Hattori, R.J.Xavier, K.Atarashi, K.Honda
- Journal Title
  
  Nature
  
  Volume: 565 Issue: 7741 Pages: 600-605
- DOI
  10.1038/s41586-019-0878-z
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-17H05799, KAKENHI-PROJECT-26221005, KAKENHI-PROJECT-17H04088, KAKENHI-PROJECT-17J01289, KAKENHI-PROJECT-17K19568, KAKENHI-PUBLICLY-19H04813, KAKENHI-PROJECT-16K08091
[Journal Article] Gut pathobionts underlie intestinal barrier dysfunction and liver T helper 17 cell immune response in primary sclerosing cholangitis.2019
- Author(s)
  Nakamoto N, Sasaki N, Aoki R, Miyamoto K, Suda W, Teratani T, Suzuki T, Koda Y, Chu PS, Taniki N, Yamaguchi A, Kanamori M, Kamada N, Hattori M, Ashida H, Sakamoto M, Atarashi K, Narushima S, Yoshimura A, Honda K, Sato T, Kanai T.
- Journal Title
  
  Nat Microbiol.
  
  Volume: 4 Issue: 3 Pages: 492-503
- DOI
  10.1038/s41564-018-0333-1
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08014, KAKENHI-PROJECT-18K15794, KAKENHI-PLANNED-26115007, KAKENHI-PROJECT-16K09374, KAKENHI-PROJECT-16K15293, KAKENHI-PROJECT-19K22544, KAKENHI-PROJECT-17H06176, KAKENHI-PROJECT-19H03455, KAKENHI-PROJECT-16H05186, KAKENHI-PROJECT-16K08091
[Journal Article] Induction of Th17 cells by segmented filamentous bacteria in the murine intestine2015
- Author(s)
  Farkas AM, Panea C, 後藤義幸, 中藤学, Galan-Diez M, 成島聖子, 本田賢也, Ivanov II
- Journal Title
  
  J Immunol Methods
  
  Volume: 421 Pages: 104-111
- DOI
  10.1016/j.jim.2015.03.020
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H06159, KAKENHI-PROJECT-26670194
[Journal Article] Th17 Cell Induction by Adhesion of Microbes to Intestinal Epithelial Cells.2015
- Author(s)
  Atarashi K, Tanoue T, Ando M, Kamada N, Nagano Y, Narushima S, et al.
- Journal Title
  
  Cell
  
  Volume: 163 Pages: 367-380
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26670194
[Presentation] 胆汁酸・脂肪酸胆汁酸エステルの同時測定法を用いた小児潰瘍性大腸炎患者の便中分析2023
- Author(s)
  武井一、成島聖子、鈴木光幸、神保圭佑、日比生武蔵、佐々木隆浩、村井毅、山下ユキコ、小川祥二郎、宇根瑞穂、入戸野博
- Organizer
  第44回胆汁酸研究会
- Data Source
  KAKENHI-PROJECT-22K08662
[Presentation] 胆汁酸・脂肪酸胆汁酸エステルの同時測定法を用いた潰瘍性大腸炎患者の便中分析2023
- Author(s)
  武井一、成島聖子、鈴木光幸、神保圭佑、佐々木隆浩、村井毅、山下ユキコ、小川祥二郎、宇根瑞穂、入戸野博
- Organizer
  第44回胆汁酸研究会
- Data Source
  KAKENHI-PROJECT-23K06511
[Presentation] 脂肪酸胆汁酸エステルはLPS誘導炎症反応を抑制する -RAW264.7細胞2022
- Author(s)
  平井沙依子、鈴木光幸、成島聖子、佐々木隆浩、村井毅、武井一、入戸野博、清水俊明
- Organizer
  第43回胆汁酸研究会
- Data Source
  KAKENHI-PROJECT-22K08662
[Presentation] 便中胆汁酸分画濃度年齢別参考値作成のための基礎的検討2018
- Author(s)
  武井一、成高中之、飯田隆、村井毅、黒澤隆夫、山城雄一郎、成島聖子、入戸野博
- Organizer
  第40会胆汁酸研究会
- Data Source
  KAKENHI-PROJECT-16K08091
[Presentation] Induction of intestinal Th1 cells by human salivary microbiota.2015
- Author(s)
  Atarashi K, Narushima S, Tanoue T, Nagano U, Honda K.
- Organizer
  第44回日本免疫学会総会
- Place of Presentation
  札幌コンベンションセンター・札幌・北海道
- Year and Date
  2015-11-20
- Data Source
  KAKENHI-PROJECT-26670194
[Presentation] SFB-mediated TH17 cell induction is influenced by mouse genetic background.2015
- Author(s)
  Tanoue T, Atarashi K, Nagano U, Watanabe E, Narushima S, Umesaki Y, Honda K.
- Organizer
  第44回日本免疫学会総会
- Place of Presentation
  札幌コンベンションセンター・札幌・北海道
- Year and Date
  2015-11-20
- Data Source
  KAKENHI-PROJECT-26670194

1. 須田亙 (20590847)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
2. OGURA Yoshio (00135849)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. HONDA Kenya (60334231)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
4. ATARASHI Koji (60546787)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
5. 鈴木光幸 (90449059)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
6. 寺嶋秀騎 (60912897)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. Li Youxian (20840185)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
8. 藤代準 (60528438)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 川島祐介 (30588124)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 渡辺栄一郎 (40623327)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 神保圭佑 (80772350)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 後藤義幸

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 改正恒康

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 寺谷俊昭

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

NARUSHIMA SEIKO 成島 聖子

成島 聖子 ナルシマ セイコ

Narushima Seiko 成島 聖子

Research Projects

Research Products

Co-Researchers

The translational research for pediatric diseases based on gut bacterial transomics analysis

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

腸内細菌の協調作用による二次胆汁酸生成の探索と宿主健康に及ぼす影響の解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Investigation of the Functional Mechanisms of Local Intestinal Microbiome and Fatty Acid-Bile Acid Esters in the Pathogenesis of Ulcerative Colitis.

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

胆汁酸・脂質エステル体産生に寄与する腸内細菌叢同定と生理学的作用機序の探索

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Unraveling the principles of microbiota function for rationally-designed biotherapeutics

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Bile acid metabolism by intestinal microbiotaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Effect of Intestinal microbiota on inflammation induced colon cancerPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Characterization of long-chain fatty acid-linked bile acids: a major conjugation form of 3β-hydroxy bile acids in feces2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Novel bile acid biosynthetic pathways are enriched in the microbiome of centenarians2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Endocytosis of commensal antigens by intestinal epithelial cells regulates mucosal T cell homeostasis2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A defined commensal consortium elicits CD8 T cells and anti-cancer immunity2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Gut pathobionts underlie intestinal barrier dysfunction and liver T helper 17 cell immune response in primary sclerosing cholangitis.2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Induction of Th17 cells by segmented filamentous bacteria in the murine intestine2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Th17 Cell Induction by Adhesion of Microbes to Intestinal Epithelial Cells.2015

Author(s)

NARUSHIMA SEIKO 成島聖子

成島聖子ナルシマセイコ

Narushima Seiko 成島聖子