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HAYASHI HIROMITSU  林 洋光

… Alternative Names

HAYASHI Hiromitsu  林 洋光

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Researcher Number 80625773
Other IDs
  • ORCIDhttps://orcid.org/0000-0002-1832-4287
Affiliation (Current) 2025: 熊本大学, 大学院生命科学研究部(医), 准教授
Affiliation (based on the past Project Information) *help 2022 – 2024: 熊本大学, 病院, 講師
2019 – 2021: 熊本大学, 病院, 助教
2018: 熊本大学, 医学部附属病院, 助教
2018: 熊本大学, 医学部附属病院, 診療講師
2014 – 2017: 熊本大学, 医学部附属病院, 非常勤診療医師 … More
2015: 熊本大学, 医学部附属病院, その他
2013 – 2014: 熊本大学, 大学院生命科学研究部, 助教
2012: 熊本大学, 大学院生命科学研究部, 特任助教 Less
Review Section/Research Field
Principal Investigator
Digestive surgery / Basic Section 55020:Digestive surgery-related
Except Principal Investigator
Digestive surgery / Basic Section 55020:Digestive surgery-related / Basic Section 50020:Tumor diagnostics and therapeutics-related / Medium-sized Section 55:Surgery of the organs maintaining homeostasis and related fields / Basic Section 55010:General surgery and pediatric surgery-related
Keywords
Principal Investigator
癌幹細胞 / 抗がん剤抵抗性 / Taz / Yap / TAZ / YAP / Hippo pathway / 消化器癌 / TGF-β / 癌 … More / Hippo-pathway / cholangiocarcinoma / EMT / TGF-β-Smadシグナル / 癌細胞増殖 / 癌細胞浸潤 / Integrin-β6 / 上皮間葉転換 / 肝内胆管癌 / トロンボスポンディン1 / TGF-beta / TSP-1 / 肝再生 / トロンボスポンディン … More
Except Principal Investigator
膵癌 / TSP-1 / 肝細胞癌 / TNF-α / PD-L1 / マクロファージ / スタチン / エピジェネティクス / 肝再生 / アポトーシス / TGF-beta / TGF-β / YAP / TAZ / がん化耐性 / 腸内細菌叢 / 消化器癌 / ハダカデバネズミ / 腸内細菌 / 免疫 / 癌 / 真菌叢 / microbiome / mycobiome / 尾側膵切除 / 側膵切除 / ミニブタ / 膵切離断端耐圧能ex vivo 試験 / 膵液瘻 / 生体吸収形状記憶膵臓クリップ / 形状記憶 / 生体吸収膵臓クリップ / KRAS遺伝子点突然変異 / KRAS遺伝子変異 / 癌幹細胞 / 膵癌幹細胞 / 癌間質細胞 / C5a受容体 / 補体C5a / cancer stemness / CAFs / Pancreatic cancer / C5a / C5a receptor / CXCL12-CXCR4 axis / CXCL12-CXCR4 signaling / signaling / CXCL12-CXCR4 / CAF / Hippo pathway / 癌微小環境 / バイオマーカー / 肝炎ウイルス / Copy数 / LINE-1 / DNAメチル化 / Amplification / レトロトランスポゾン / 非肝炎ウイルス性肝細胞癌 / TGF / 抗がん剤抵抗性 / EMT / 免疫学的癌微小環境 / サルコペニア / 腫瘍浸潤マクロファージ / 腫瘍免疫 / PD-1 / 腫瘍微小環境 / 免疫チェックポイント / 腫瘍免疫学 / LSKL peptide / Sorafenib / Hepatectomy / HCC / 肝切除術 / SB203580 / p38 MAP kinase / sorafenib / Thrombospondin 1 / 肝中心静脈閉塞症 / bevacizumab / Thrombospondin-1(TSP-1) / oxaliplatin / 肝類洞閉塞症候群 / 大腸癌肝転移 / statin(スタチン) / Elk-1 / pAkt / pERK / 薬剤耐性 / 相乗効果 / 併用療法 / BRAF / K-ras / Akt/PKB / MEK/ERK / 大腸癌 / Angiogenesis / 細胞周期 / 胆管癌 / DZNep / Notch1 / 細胞増殖 / 血管新生 / VASH1 / EZH2 / 肝内胆管癌 / エピジェネティック / miRNA / 食道扁平上皮癌 / メチル化 / miRNA(キーワード3) / Farnesoid受容体X / 胆汁酸 / FXR / 肝切除 / FXR agonist / Smad2 / 増殖 / 肝肥大 / 肝血流低下 / 増殖抑制 / 肝類洞内皮細胞 / 肝細胞アポトーシス誘導 / 肝細胞増殖抑制 / 肝萎縮 / 門脈血流低下 / methylatiom / rho family / CDH3 / Akt/Ark signal / Rho family / migration / invasion / promoter / unmethylation / methylation / P-cadherin / 浸潤・転移 / Hippo-pathway / Chemoresistance / Long non-coding RNA / 膵臓癌 / HOTAIR導入 / 転移性肝癌 / HOTAIR / 転移性肝腫瘍 Less
  • Research Projects

    (25 results)
  • Research Products

    (89 results)
  • Co-Researchers

    (35 People)
  •  がん幹細胞能維持と免疫回避微小環境を誘導する機構解明と新規治療法の開発Principal Investigator

    • Principal Investigator
      林 洋光
    • Project Period (FY)
      2024 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 55020:Digestive surgery-related
    • Research Institution
      Kumamoto University
  •  真菌叢を標的とした消化器癌に対する革新的治療法の開発

    • Principal Investigator
      美馬 浩介
    • Project Period (FY)
      2024 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 55020:Digestive surgery-related
    • Research Institution
      Kumamoto University
  •  消化器癌の革新的治療法開発を目指したハダカデバネズミ腸内細菌のマルチオミクス解析

    • Principal Investigator
      馬場 秀夫
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 55020:Digestive surgery-related
    • Research Institution
      Kumamoto University
  •  Analysis of KRAS point mutation in pancreatic cancer

    • Principal Investigator
      Chikamoto Akira
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 50020:Tumor diagnostics and therapeutics-related
    • Research Institution
      Kumamoto University
  •  生体吸収形状記憶膵臓クリップを用いた革新的膵切離法に関する医工連携研究

    • Principal Investigator
      山下 洋市
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Challenging Research (Exploratory)
    • Review Section
      Medium-sized Section 55:Surgery of the organs maintaining homeostasis and related fields
    • Research Institution
      ASO CORPORATION(ASO IIZUKA HOSPITAL)
      Kumamoto University
  •  The significance and the mechanism of PD-L1 expression in the tumor microenvironment for novel therapeutic agents

    • Principal Investigator
      Tsukamoto Masayo
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 55010:General surgery and pediatric surgery-related
    • Research Institution
      Kumamoto University
  •  Interaction between Hippo pathway and cancer microenvironment in pancreatic cancer.

    • Principal Investigator
      Higashi Takaaki
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 55020:Digestive surgery-related
    • Research Institution
      Kumamoto University
  •  Targeting therapy of C5a receptor on cancer associated fibroblast control pancreatic cancer stemness

    • Principal Investigator
      Nitta Hidetoshi
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 55020:Digestive surgery-related
    • Research Institution
      Kumamoto University
  •  LINE-1methylation in nonhepatitis virus hepatocellular carcinoma

    • Principal Investigator
      Beppu Toru
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 50020:Tumor diagnostics and therapeutics-related
    • Research Institution
      Kumamoto University
  •  Biological roles of dysregulated Hippo pathway on cancer stem like function during the tumor progression of gastroenterological cancersPrincipal Investigator

    • Principal Investigator
      Hayashi Hiromitsu
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 55020:Digestive surgery-related
    • Research Institution
      Kumamoto University
  •  Signal crosstalk between TGF-beta and Hippo-pathway in pancreatic

    • Principal Investigator
      CHIKAMOTO Akira
    • Project Period (FY)
      2018 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 55020:Digestive surgery-related
    • Research Institution
      Kumamoto University
  •  TSP-1 expression of hepatocellular carcinoma in recurrence and metastasis after hepatectomy: the mechanism and therapeutic strategy.

    • Principal Investigator
      Kuroki Hideyuki
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Digestive surgery
    • Research Institution
      Kumamoto University
  •  Sarcopenia and immunological tumor microenvironment

    • Principal Investigator
      Imai Katsunori
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Digestive surgery
    • Research Institution
      Kumamoto University
  •  Elucidation of anti-tumor effect mechanism of statin in colorectal cancer and development of new treatment

    • Principal Investigator
      ISHIKAWA Shinji
    • Project Period (FY)
      2016 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Digestive surgery
    • Research Institution
      Kumamoto University
  •  Biological significance of Hippo-pathway in gastrointestinal cancerPrincipal Investigator

    • Principal Investigator
      HAYASHI Hiromitsu
    • Project Period (FY)
      2016 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Digestive surgery
    • Research Institution
      Kumamoto University
  •  Comprehensive analysis of the relationship between DNA methylation and miRNA expression in esophageal carcinoma

    • Principal Investigator
      SAITOU Seiya
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Digestive surgery
    • Research Institution
      Kumamoto University
  •  Drug screening for cholangiocarcinoma targeting the epigenetical mechanism of cancer progression

    • Principal Investigator
      CHIKAMOTO Akira
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Digestive surgery
    • Research Institution
      Kumamoto University
  •  Clarification the molecular mechanism of chemotherapy-related sinusoidal obstructive syndrome and the study for efficacy of anti–vascular endothelial growth factor therapy.

    • Principal Investigator
      KUROKI Hideyuki
    • Project Period (FY)
      2015 – 2016
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Digestive surgery
    • Research Institution
      Kumamoto University
  •  Relation of P-cadherin and Rho family in intrahepatic cholangiocarcinoma

    • Principal Investigator
      HORINO Kei
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Digestive surgery
    • Research Institution
      Kumamoto University
  •  The mechanism of liver atrophy after portal vein hypoperfusion and therapeutic method using LSKL peptide

    • Principal Investigator
      IKUTA Yoshiaki
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Digestive surgery
    • Research Institution
      Kumamoto University
  •  Clinical implication of Farnesoid-X-receptor agonist in liver regeneration after hepatectomy

    • Principal Investigator
      TAKAMORI Hiroshi
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Digestive surgery
    • Research Institution
      Kumamoto University
  •  Integrin-beta 6 is required for TGF-beta-mediated EMT and promotes the disease progression of intrahepatic cholangiocellular carcinomaPrincipal Investigator

    • Principal Investigator
      HAYASHI Hiromitsu
    • Project Period (FY)
      2014 – 2015
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Digestive surgery
    • Research Institution
      Kumamoto University
  •  Biological significance of crosstalk between TGF-beta and Hippo pathway in HCC progression

    • Principal Investigator
      KURAMOTO Kunitaka
    • Project Period (FY)
      2013 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Digestive surgery
    • Research Institution
      Kumamoto University
  •  Analysis of function of long non-coding RNA associated with liver metastasis from pancreatic cancer

    • Principal Investigator
      NAKAHARA osamu
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Digestive surgery
    • Research Institution
      Kumamoto University
  •  Novel therapeutic strategy for liver regeneration focusing on local TGF-beta activation mechanismPrincipal Investigator

    • Principal Investigator
      HAYASHI Hiromitsu
    • Project Period (FY)
      2012 – 2013
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Digestive surgery
    • Research Institution
      Kumamoto University

All 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012

All Journal Article Presentation

  • [Journal Article] Hyperglycaemia induces metabolic reprogramming into a glycolytic phenotype and promotes epithelial-mesenchymal transitions via YAP/TAZ-Hedgehog signalling axis in pancreatic cancer.2023

    • Author(s)
      Liu Z,
    • Journal Title

      Br J Cancer.

      Volume: 128(5) Issue: 5 Pages: 844-856

    • DOI

      10.1038/s41416-022-02106-9

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21K08757, KAKENHI-PROJECT-20K09059, KAKENHI-PROJECT-20K09081, KAKENHI-PROJECT-21K15534
  • [Journal Article] Biological and Clinical Impacts of Glucose Metabolism in Pancreatic Ductal Adenocarcinoma2023

    • Author(s)
      Liu Zhao、Hayashi Hiromitsu、Matsumura Kazuki、Uemura Norio、Shiraishi Yuta、Sato Hiroki、Baba Hideo
    • Journal Title

      Cancers

      Volume: 15 Issue: 2 Pages: 498-498

    • DOI

      10.3390/cancers15020498

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20K09081
  • [Journal Article] Statin as a therapeutic agent in gastroenterological cancer2022

    • Author(s)
      Uemura Norio、Hayashi Hiromitsu、Baba Hideo
    • Journal Title

      World Journal of Gastrointestinal Oncology

      Volume: 14 Issue: 1 Pages: 110-123

    • DOI

      10.4251/wjgo.v14.i1.110

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K09177
  • [Journal Article] High Expression of Bloom Syndrome Helicase is a Key Factor for Poor Prognosis and Advanced Malignancy in Patients with Pancreatic Cancer: A Retrospective Study2022

    • Author(s)
      Lan Chuan、Yamashita Yo-ichi、Hayashi Hiromitsu、Nakagawa Shigeki、Imai Katsunori、Mima Kosuke、Kaida Takayoshi、Matsumoto Takashi、Maruno Masataka、Liu Zhao、Wu Xiyu、Wei Feng、Baba Hideo
    • Journal Title

      Annals of Surgical Oncology

      Volume: 29 Issue: 6 Pages: 3551-3564

    • DOI

      10.1245/s10434-022-11500-9

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20K09081
  • [Journal Article] Thrombospondin-1 overexpression stimulates loss of Smad4 and accelerates malignant behavior via TGF-β signal activation in pancreatic ductal adenocarcinoma2022

    • Author(s)
      Matsumura Kazuki、Hayashi Hiromitsu、Uemura Norio、Ogata Yoko、Zhao Liu、Sato Hiroki、Shiraishi Yuta、Kuroki Hideyuki、Kitamura Fumimasa、Kaida Takayoshi、Higashi Takaaki、Nakagawa Shigeki、Mima Kosuke、Imai Katsunori、Yamashita Yo-ichi、Baba Hideo
    • Journal Title

      Translational Oncology

      Volume: 26 Pages: 101533-101533

    • DOI

      10.1016/j.tranon.2022.101533

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20K09081
  • [Journal Article] Survival Impact of Perioperative Red Blood Cell Transfusion During Pancreatectomy in Patients With Pancreatic Ductal Adenocarcinoma2022

    • Author(s)
      Kitano Yuki、Yamashita Yo-ichi、Matsumoto Takashi、Kinoshita Shotaro、Itoyama Rumi、Kaida Takayoshi、Hayashi Hiromitsu、Imai Katsunori、Chikamoto Akira、Baba Hideo
    • Journal Title

      Pancreas

      Volume: 51 Issue: 2 Pages: 200-204

    • DOI

      10.1097/mpa.0000000000001997

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21K07221
  • [Journal Article] The Impact of Histologic Liver Inflammation on Oncology and the Prognosis of Patients Undergoing Hepatectomy for Hepatocellular Carcinoma2021

    • Author(s)
      Miyata Tatsunori、Hayashi Hiromitsu、Yamashita Yo-ichi、Matsumura Kazuki、Higashi Takaaki、Imai Katsunori、Nitta Hidetoshi、Chikamoto Akira、Beppu Toru、Baba Hideo
    • Journal Title

      Annals of Surgical Oncology

      Volume: 29 Issue: 2 Pages: 893-902

    • DOI

      10.1245/s10434-021-10706-7

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19K07777, KAKENHI-PROJECT-20K16418
  • [Journal Article] Alteration of prognostic efficacy of albumin‐bilirubin grade and Child‐Pugh score according to liver fibrosis in hepatocellular carcinoma patients with Child‐Pugh A following hepatectomy2021

    • Author(s)
      Miyata Tatsunori、Yamashita Yo‐ichi、Arima Kota、Higashi Takaaki、Hayashi Hiromitsu、Imai Katsunori、Nitta Hidetoshi、Chikamoto Akira、Beppu Toru、Baba Hideo
    • Journal Title

      Annals of Gastroenterological Surgery

      Volume: 6 Issue: 1 Pages: 127-134

    • DOI

      10.1002/ags3.12498

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K07777, KAKENHI-PROJECT-20K16418
  • [Journal Article] Conversion Surgery for Hepatocellular Carcinoma Following Molecular Therapy2021

    • Author(s)
      YAMAMURA KENSUKE、BEPPU TORU、MIYATA TATSUNORI、OKABE HIROHISA、NITTA HIDETOSHI、IMAI KATSUNORI、HAYASHI HIROMITSU、AKAHOSHI SHINICHI
    • Journal Title

      Anticancer Research

      Volume: 42 Issue: 1 Pages: 35-44

    • DOI

      10.21873/anticanres.15454

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19K07777, KAKENHI-PROJECT-20K16418, KAKENHI-PROJECT-21K15596
  • [Journal Article] Inflammatory Liver Tumor Caused by Fasciola hepatica Mimicking Intrahepatic Cholangiocarcinoma2020

    • Author(s)
      KAIDA TAKAYOSHI、BEPPU TORU、HAYASHI HIROMITSU、IMAI KATSUNORI、YAMAMURA KENSUKE、OKABE HIROHISA、MATSUMURA KAZUKI、YOSHII DAIKI、KOMOHARA YOSHIHIRO、AKAHOSHI SHINICHI、DOI KOICHI、YAMASHITA YO-ICHI、BABA HIDEO
    • Journal Title

      Anticancer Research

      Volume: 40 Issue: 5 Pages: 2795-2800

    • DOI

      10.21873/anticanres.14252

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19K07777
  • [Journal Article] Extracellular Vesicles from Cancer-Associated Fibroblasts Containing Annexin A6 Induces FAK-YAP Activation by Stabilizing β1 Integrin, Enhancing Drug Resistance2020

    • Author(s)
      Uchihara T, Miyake K, Yonemura A, Komohara Y, Itoyama R, Koiwa M, Yasuda T, Arima K, Harada K, Eto K, Hayashi H, Iwatsuki M, Iwagami S, Baba Y, Yoshida N, Yashiro M, Masuda M, Ajani Jaffer A, Tan Patrick, Baba H, Ishimoto T
    • Journal Title

      Cancer Research

      Volume: 80 Issue: 16 Pages: 3222-3235

    • DOI

      10.1158/0008-5472.can-19-3803

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K09177, KAKENHI-PROJECT-20K07690, KAKENHI-PROJECT-20K08985, KAKENHI-PROJECT-18H02694, KAKENHI-PROJECT-20H03531, KAKENHI-PROJECT-18K08543, KAKENHI-PROJECT-19K16720, KAKENHI-PROJECT-19K16749, KAKENHI-PROJECT-18H02883
  • [Journal Article] CD44 expression enhances chemoresistance and implies occult micrometastases after conversion hepatectomy for initially unresectable colorectal liver metastases2020

    • Author(s)
      Hiromitsu Hayashi, Yuji Miyamoto, Takaaki Higashi, Yukiharu Hiyoshi, Takanobu Yamao, Norio Uemura, Kazuki Matsumura, Katsunori Imai, Yo-ichi Yamashita, Hideo Baba
    • Journal Title

      Am J Transl Res

      Volume: 12(9) Pages: 5955-5966

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K09177
  • [Journal Article] Prognostic Value of the Preoperative Tumor Marker Index in Resected Pancreatic Ductal Adenocarcinoma: A Retrospective Single-Institution Study2020

    • Author(s)
      Miyata Tatsunori、Hayashi Hiromitsu、Yamashita Yo-ichi、Matsumura Kazuki、Nakao Yosuke、Itoyama Rumi、Yamao Takanobu、Tsukamoto Masayo、Okabe Hirohisa、Imai Katsunori、Chikamoto Akira、Ishiko Takatoshi、Baba Hideo
    • Journal Title

      Annals of Surgical Oncology

      Volume: 28 Issue: 3 Pages: 1572-1580

    • DOI

      10.1245/s10434-020-09022-3

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20K16418, KAKENHI-PROJECT-18K08651
  • [Journal Article] Varied application of intercostal trans-diaphragmatic ports for laparoscopic hepatectomy2020

    • Author(s)
      Hayashi Hiromitsu、Yamashita Yo-ichi、Okabe Hirohisa、Imai Katsunori、Higashi Takaaki、Yamamura Kensuke、Chikamoto Akira、Beppu Toru、Takamori Hiroshi、Baba Hideo
    • Journal Title

      PLOS ONE

      Volume: 15 Issue: 6 Pages: e0234919-e0234919

    • DOI

      10.1371/journal.pone.0234919

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K07777, KAKENHI-PROJECT-18K08623
  • [Journal Article] Lysyl oxidase induces epithelial‐mesenchymal transition and predicts intrahepatic metastasis of hepatocellular carcinoma2019

    • Author(s)
      Umezaki Naoki、Nakagawa Shigeki、Yamashita Yo‐ichi、Kitano Yuki、Arima Kota、Miyata Tatsunori、Hiyoshi Yukiharu、Okabe Hirohisa、Nitta Hidetoshi、Hayashi Hiromitsu、Imai Katsunori、Chikamoto Akira、Baba Hideo
    • Journal Title

      Cancer Science

      Volume: 110(6) Issue: 6 Pages: 2033-2043

    • DOI

      10.1111/cas.14010

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16K19939, KAKENHI-PROJECT-19K16721, KAKENHI-PROJECT-17K10670
  • [Journal Article] Is disease progression a contraindication for the strategy of portal vein embolization followed by hepatectomy for hepatocellular carcinoma?2019

    • Author(s)
      Imai Katsunori、Yamashita Yo-ichi、Nakao Yosuke、Uemura Norio、Kitamura Fumimasa、Miyata Tatsunori、Nakagawa Shigeki、Okabe Hirohisa、Hayashi Hiromitsu、Chikamoto Akira、Ishiko Takatoshi、Baba Hideo
    • Journal Title

      Surgery

      Volume: 165 Issue: 4 Pages: 696-702

    • DOI

      10.1016/j.surg.2018.10.023

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K10670
  • [Journal Article] Validation of Functional Assessment for Liver Resection Considering Venous Occlusive Area after Extended Hepatectomy.2019

    • Author(s)
      Nitta H, Kitano Y, Miyata T, Nakagawa S, Mima K, Okabe H, Hayashi H, Imai K, Yamashita YI, Chikamoto A, Beppu T, Baba H.
    • Journal Title

      J Gastrointest Surg.

      Volume: 24 Issue: 7 Pages: 1510-1519

    • DOI

      10.1007/s11605-019-04234-9

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19K07777
  • [Journal Article] A 12-year Recurrence-free Survival After Multidisciplinary Treatment for a Patient With Combined Hepatocellular?Cholangiocarcinoma2019

    • Author(s)
      MIYATA TATSUNORI、BEPPU TORU、IMAMURA YU、HAYASHI HIROMITSU、IMAI KATSUNORI、CHIKAMOTO AKIRA、YAMASHITA YO-ICHI、FUKUBAYASHI KOTARO、ISHIKO TAKATOSHI、BABA HIDEO
    • Journal Title

      Anticancer Research

      Volume: 39 Issue: 4 Pages: 2139-2144

    • DOI

      10.21873/anticanres.13327

    • Data Source
      KAKENHI-PROJECT-19K07777
  • [Journal Article] Histological architectural classification determines recurrence pattern and prognosis after curative hepatectomy in patients with hepatocellular carcinoma2018

    • Author(s)
      Okabe Hirohisa、Yoshizumi Tomoharu、Yamashita Yo-ichi、Imai Katsunori、Hayashi Hiromitsu、Nakagawa Shigeki、Itoh Shinji、Harimoto Norifumi、Ikegami Toru、Uchiyama Hideaki、Beppu Toru、Aishima Shinichi、Shirabe Ken、Baba Hideo、Maehara Yoshihiko
    • Journal Title

      PLOS ONE

      Volume: 13 Issue: 9 Pages: e0203856-e0203856

    • DOI

      10.1371/journal.pone.0203856

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K10670, KAKENHI-PROJECT-16K19936
  • [Journal Article] Hepatic Resection Followed by Hepatic Arterial Infusion Chemotherapy for Hepatocellular Carcinoma with Intrahepatic Dissemination.2018

    • Author(s)
      Kuramoto K, Beppu T, Nitta H, Imai K, Masuda T, Miyata T, Koga Y, Kitano Y, Kaida T, Nakagawa S, Okabe H, Hayashi H, Hashimoto D, Yamashita YI, Chikamoto A, Kikuchi K, Baba H.
    • Journal Title

      Anticancer Res.

      Volume: 38(1) Pages: 525-531

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K10670
  • [Journal Article] Predicting Poorly Differentiated Hepatocellular Carcinoma that Meets the Milan Criteria2018

    • Author(s)
      KOGA YUKI、BEPPU TORU、MIYATA TATSUNORI、KITANO YUKI、TSUJI AKIRA、NAKAGAWA SHIGEKI、ARIMA KOTA、KURAMOTO KUNITAKA、OKABE HIROHISA、IMAI KATSUNORI、HAYASHI HIROMITSU、NITTA HIDETOSHI、YAMASHITA YO-ICHI、CHIKAMOTO AKIRA、ISHIKO TAKATOSHI、BABA HIDEO
    • Journal Title

      Anticancer Research

      Volume: 38 Issue: 7 Pages: 4093-4099

    • DOI

      10.21873/anticanres.12699

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K10670, KAKENHI-PROJECT-18K16370
  • [Journal Article] Impact of surgical treatment after sorafenib therapy for advanced hepatocellular carcinoma2018

    • Author(s)
      Takeyama Hideaki、Beppu Toru、Higashi Takaaki、Kaida Takayoshi、Arima Kota、Taki Katsunobu、Imai Katsunori、Nitta Hidetoshi、Hayashi Hiromitsu、Nakagawa Shigeki、Okabe Hirohisa、Hashimoto Daisuke、Chikamoto Akira、Ishiko Takatoshi、Tanaka Motohiko、Sasaki Yutaka、Baba Hideo
    • Journal Title

      Surgery Today

      Volume: 48 Issue: 4 Pages: 431-438

    • DOI

      10.1007/s00595-017-1603-x

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K10670
  • [Journal Article] Erratum to: Sarcopenia, but not visceral fat amount, is a risk factor of postoperative complications after major hepatectomy.2017

    • Author(s)
      Higashi T, Hayashi H, Taki K, Sakamoto K, Kuroki H, Nitta H, Hashimoto D, Chikamoto A, Beppu T, Baba H.
    • Journal Title

      Int J Clin Oncol.

      Volume: 22(5) Issue: 5 Pages: 986-990

    • DOI

      10.1007/s10147-017-1163-5

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K10670
  • [Journal Article] C5a receptor (CD88) promotes motility and invasiveness of gastric cancer by activating RhoA.2016

    • Author(s)
      Kaida T, Nitta H, Kitano Y, Yamamura K, Arima K, Izumi D, Higashi T, Kurashige J, Imai K, Hayashi H, Iwatsuki M, Ishimoto T, Hashimoto D, Yamashita Y, Chikamoto A, Imanura T, Ishiko T, Beppu T, Baba H.
    • Journal Title

      Oncotarget.

      Volume: 20(7) Issue: 51 Pages: 84798-84809

    • DOI

      10.18632/oncotarget.12656

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-15K19900, KAKENHI-PROJECT-15K10171, KAKENHI-PROJECT-15K10191, KAKENHI-PROJECT-16K10503
  • [Journal Article] Statin attenuates cell proliferative ability via TAZ (WWTR1) in hepatocellular carcinoma.2016

    • Author(s)
      Higashi T, Hayashi H, Kitano Y, Yamamura K, Kaida T, Arima K, Taki K, Nakagawa S, Okabe H, Nitta H, Imai K, Hashimoto D, Chikamoto A, Beppu T, Baba H.
    • Journal Title

      Med Oncol.

      Volume: 33(11) Issue: 11 Pages: 123-123

    • DOI

      10.1007/s12032-016-0845-6

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-15K10191, KAKENHI-PROJECT-16K19939, KAKENHI-PROJECT-16K19940
  • [Journal Article] Inducible factors for cancer-associated fibroblasts in liver cancer versus myofibroblasts in inflammatory liver disease.2016

    • Author(s)
      Okabe H, Hayashi H, Nakagawa S, Imai K, Nitta H, Arima K, Hashimoto D, Chikamoto A, Ishiko T, Beppu T, Baba H.
    • Journal Title

      Histol Histopathol

      Volume: 31(2) Pages: 141-8

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-26462047
  • [Journal Article] Thrombospondin-1 expression may be implicated in liver atrophic mechanism due to obstructed portal venous flow.2016

    • Author(s)
      Hayashi H, Kuroki H, Higashi T, Takeyama H, Yokoyama N, Okabe H, Nitta H, Beppu T, Takamori H, Baba H.
    • Journal Title

      Hepatol Res

      Volume: Epub Issue: 8 Pages: 803-812

    • DOI

      10.1111/hepr.12792

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-26462046, KAKENHI-PROJECT-17K10670
  • [Journal Article] Heat injury to the inferior vena cava by bipolar tissue sealer.2016

    • Author(s)
      Chikamoto A, Kaida T, Arima K, Higashi T, Taki K, Ida S, Okabe H, Nitta H, Hayashi H, Hashimoto D, Watanabe M, Beppu T, Baba H.
    • Journal Title

      Surg Endosc

      Volume: 30(4) Issue: 4 Pages: 1519-22

    • DOI

      10.1007/s00464-015-4365-9

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-26462046
  • [Journal Article] Significance of P-cadherin overexpression and possible mechanism of its regulation in intrahepatic cholangiocarcinoma and pancreatic cancer.2015

    • Author(s)
      Sakamoto K, Imai K, Higashi T, Taki K, Nakagawa S, Okabe H, Nitta H, Hayashi H, Chikamoto A, Ishiko T, Beppu T, Baba H.
    • Journal Title

      Cancer Sci

      Volume: 106(9) Issue: 9 Pages: 1153-62

    • DOI

      10.1111/cas.12732

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-15K10191, KAKENHI-PROJECT-26462045
  • [Journal Article] miR-9-3p plays a tumour-suppressor role by targeting TAZ (WWTR1) in hepatocellular carcinoma cells.2015

    • Author(s)
      Higashi, T., Hayashi, H., Ishimoto, T., Takeyama, H., Kaida, T., Arima, K., Taki, K., Sakamoto, K., Kuroki, H., Okabe, H., Nitta, H., Hashimoto, D., Chikamoto, A., Beppu, T., Baba, H.
    • Journal Title

      Br J Cancer

      Volume: 14;113(2) Issue: 2 Pages: 252-8

    • DOI

      10.1038/bjc.2015.170

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25462098, KAKENHI-PROJECT-26861089, KAKENHI-PROJECT-26293290
  • [Journal Article] Pyoderma gangrenosum in an abdominal surgical site: a case report.2015

    • Author(s)
      Ogata K, Takamori H, Ikuta Y, Tanaka H, Ozaki N, Hayashi H, Ogawa K, Doi K.
    • Journal Title

      Surg Case Rep

      Volume: 1(1) Issue: 1 Pages: 122-122

    • DOI

      10.1186/s40792-015-0124-3

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-26462047
  • [Journal Article] Functional assessment versus conventional volumetric assessment in the prediction of operative outcomes after major hepatectomy2015

    • Author(s)
      Hayashi H, Beppu T, Okabe H, Kuroki H, Nakagawa S, Imai K, Nitta H, Chikamoto A, Ishiko T, Baba H
    • Journal Title

      Surgery

      Volume: 157(1) Issue: 1 Pages: 20-6

    • DOI

      10.1016/j.surg.2014.06.013

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24592034, KAKENHI-PROJECT-26861088, KAKENHI-PROJECT-26462046
  • [Journal Article] An Imbalance in TAZ and YAP Expression in Hepatocellular Carcinoma Confers Cancer Stem Cell-like Behaviors Contributing to Disease Progression.2015

    • Author(s)
      Hayashi H, Higashi T, Yokoyama N, Kaida T, Sakamoto K, Fukushima Y, Ishimoto T, Kuroki H, Nitta H, Hashimoto D, Chikamoto A, Oki E, Beppu T, Baba H.
    • Journal Title

      Cancer Res.

      Volume: 75(22) Issue: 22 Pages: 4985-97

    • DOI

      10.1158/0008-5472.can-15-0291

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15K10191, KAKENHI-PROJECT-26462046, KAKENHI-PROJECT-25462098, KAKENHI-PROJECT-26293290
  • [Journal Article] Scoring system based on tumor markers and Child-Pugh classification for HCC patients who underwent liver resection.2015

    • Author(s)
      Nakagawa S, Hayashi H, Nitta H, Okabe H, Sakamoto K, Higashi T, Kuroki H, Imai K, Hashimoto D, Sakamoto Y, Chikamoto A, Beppu T, Baba H.
    • Journal Title

      Anticancer Res

      Volume: 35(4) Pages: 2157-63

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-15K10191
  • [Journal Article] Prognostic value of Ki-67 expression in conversion therapy for colorectal liver-limited metastases.2015

    • Author(s)
      Hayashi H, Beppu T, Sakamoto Y, Miyamoto Y, Yokoyama N, Higashi T, Nitta H, Hashimoto D, Chikamoto A, Baba H.
    • Journal Title

      Am J Cancer Res

      Volume: 15;5(3) Pages: 1225-33

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-26462046
  • [Journal Article] Management of thrombocytopenia due to liver cirrhosis; a review2014

    • Author(s)
      Hayashi H, Beppu T, Shirabe K, Maehara Y, Baba H.
    • Journal Title

      World J Gastroenterology

      Volume: 20(10) Issue: 10 Pages: 2595-2605

    • DOI

      10.3748/wjg.v20.i10.2595

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24592034
  • [Journal Article] EZH2 Is Associated with Malignant Behavior in Pancreatic IPMN via p27Kip1 Downregulation2014

    • Author(s)
      Kuroki H, Hayashi H, Okabe H, Hashimoto D, Takamori H, Nakahara O, Nakagawa S, Fukushima Y, Chikamoto A, Beppu T, Hirota M, Iyama K, Baba H
    • Journal Title

      PLOS ONE

      Volume: 9(8) Issue: 8 Pages: e100904-e100904

    • DOI

      10.1371/journal.pone.0100904

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24592033, KAKENHI-PROJECT-24592034, KAKENHI-PROJECT-26462047
  • [Journal Article] The modified Glasgow Prognostic Score (mGPS) is a good predictor of indication for palliative bypass surgery in patients with unresectable pancreatic and biliary cancers2014

    • Author(s)
      Ikuta Y, Takamori H, Sakamoto Y, Hashimoto D, Chikamoto A, Kuroki H, Sakata K, Sakamoto K, Hayashi H, Imai K, Nitta H, Hirota M, Kanemitsu K, Beppu T, Baba H
    • Journal Title

      Int J Clin Oncol

      Volume: 19(4) Issue: 4 Pages: 629-33

    • DOI

      10.1007/s10147-013-0613-y

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24791384, KAKENHI-PROJECT-26462046
  • [Journal Article] Rank classification based on the combination of indocyanine green retention rate at 15 min and (99m)Tc-DTPA-galactosyl human serum albumin scintigraphy predicts the safety of hepatic resection2014

    • Author(s)
      Okabe H, Beppu T, Hayashi H, Masuda T, Mima K, Nakagawa S, Kuroki H, Imai K, Nitta H, Masuda T, Hashimoto D, Chikamoto A, Wanatanabe M, Ishiko T, Yoshida M, Yamashita Y, Baba H.
    • Journal Title

      Nucl Med Commun

      Volume: 35 Issue: 5 Pages: 478-483

    • DOI

      10.1097/mnm.0000000000000075

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23791549, KAKENHI-PROJECT-26462047
  • [Journal Article] Tumor Shrinkage in Response to Vitamin K2 in Hepatocellular Carcinoma with Multiple Lung Metastases: A Case Report2014

    • Author(s)
      Hayashi H, Higashi T, Takeyama H, Sakamoto K, Kuroki H, Nitta H, Hashimoto D, Chikamoto A, Beppu T, Baba H
    • Journal Title

      AJCC Rep

      Volume: 2(2) Pages: 20140548-554

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-26861088
  • [Journal Article] Tumor Shrinkage in Response to Vitamin K2 in Hepatocellular Carcinoma with Multiple Lung Metastases: A Case Report2014

    • Author(s)
      Hayashi H, Higashi T, Takeyama H, Sakamoto K, Kuroki H, Nitta H, Hashimoto D, Chikamoto A, Beppu T, Baba H
    • Journal Title

      AJCC Rep

      Volume: 2(2) Pages: 548-554

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24592034
  • [Journal Article] Pancreatic metastasis from mixed adenoneuroendocrine carcinoma of the uterine cervix: a case report.2013

    • Author(s)
      Nishimura C, Naoe H, Hashigo S, Tsutsumi H, Ishii S, Konoe T, Watanabe T, Shono T, Sakurai K, Takaishi K, Ikuta Y, Chikamoto A, Tanaka M, Iyama K, Baba H, Katabuchi H, Sasaki Y.
    • Journal Title

      Case reports in oncology

      Volume: 6(2) Issue: 4 Pages: 256-62

    • DOI

      10.1007/s13691-014-0159-5

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24791435, KAKENHI-PROJECT-26462046
  • [Journal Article] Percentage of future liver remnant volume before portal vein embolization influences the degree of liver regeneration after hepatectomy. J Gastrointest Surg2013

    • Author(s)
      Okabe H, Beppu T, Nakagawa S, Yoshida M, Hayashi H, Masuda T, Imai K, Mima K, Kuroki H, Nitta H, Hashimoto D, Chikamoto A, Ishiko T, Watanabe M, Yamashita Y, Baba H.
    • Journal Title

      J Gastrointest Surg

      Volume: 17(8) Issue: 8 Pages: 1447-51

    • DOI

      10.1007/s11605-013-2237-y

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23791549, KAKENHI-PROJECT-24791434
  • [Journal Article] Biological significance of latent TGF-βactivation in liver.2012

    • Author(s)
      林 洋光
    • Journal Title

      Frontiers in Physiology

      Volume: 3 Pages: 12-12

    • DOI

      10.3389/fphys.2012.00012

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24791434
  • [Journal Article] External biliary drainage and liver regeneration after major hepatectomy.2012

    • Author(s)
      太田尾 龍、岡部 弘尚、他
    • Journal Title

      British Journal of Surgery

      Volume: 99 Issue: 11 Pages: 1569-1574

    • DOI

      10.1002/bjs.8906

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23791549, KAKENHI-PROJECT-24791434
  • [Journal Article] CD44s regulates the TGF-β-mediated mesenchymal phenotype and is associated with poor prognosis in patients with hepatocellular carcinoma2012

    • Author(s)
      Mima K, Okabe H, Ishimoto T, Hayashi H, Nakagawa S, Kuroki H, Watanabe M, Beppu T, Tamada M, Nagano O, Saya H, Baba H
    • Journal Title

      Cancer Res

      Volume: 1;72(13) Pages: 3414-23

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24791434
  • [Journal Article] Thrombospondin-1 is a novel negative regulator of liver regeneration after partial hepatectomy through transforming growth factor-beta1 activation in mice2012

    • Author(s)
      Hayashi H, Sakai K, Baba H, Sakai T
    • Journal Title

      Hepatology

      Volume: 55(5) Issue: 5 Pages: 1562-73

    • DOI

      10.1002/hep.24800

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24791434
  • [Journal Article] Biological Significance of Local TGF-β Activation in Liver Diseases2012

    • Author(s)
      Hayashi H, Sakai T
    • Journal Title

      Front Physiol

      Volume: 6;3 Pages: 12-12

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24791434
  • [Presentation] 肝細胞癌の特性に応じた治療戦略開発の必要性 -当科における1027例の初回肝切除経験を踏まえて-2023

    • Author(s)
      宮田辰徳、林洋光、松本嵩史、上村将太、金光紘介、足立優樹、塚本雅代、中川茂樹、美馬浩介、新田英利、馬場秀夫
    • Organizer
      第123回日本外科学会定期学術集会
    • Data Source
      KAKENHI-PROJECT-20K09059
  • [Presentation] 膵癌間質に由来する Thrombospondin-1 は膵癌の増殖・浸潤に寄与する2022

    • Author(s)
      松村和季、林洋光、北村文優、甲斐田剛圭、中川茂樹、美馬浩介、今井克憲、山下洋市、馬場秀夫
    • Organizer
      第122回日本外科学会定期学術集会
    • Data Source
      KAKENHI-PROJECT-20K09081
  • [Presentation] 膵癌が産生する乳酸が腫瘍微小環境に与える影響に関する分子生物学的検討2022

    • Author(s)
      北村文優、石本崇胤、木下翔太郎、松本嵩史、武末亨、松村和季、秋山貴彦、丸野正敬、甲斐田剛圭、中川茂樹、美馬浩介、今井克憲、林洋光、山下洋市、馬場秀夫
    • Organizer
      第122回日本外科学会定期学術集会
    • Data Source
      KAKENHI-PROJECT-20K09081
  • [Presentation] 膵癌患者のグラスゴー予後スコア(GPS)におけるconditional borderlineresectable(C-BR)症例と術後の合併症および長期予後の検討2022

    • Author(s)
      白石裕大、中川茂樹、湯本信成、小川大輔、佐藤寛紀、松本嵩史、武末亨、丸野正敬、塚本雅代、甲斐田剛圭、美馬浩介、林洋光、今井克憲、山下洋市、馬場秀夫
    • Organizer
      第43回癌免疫外科研究会
    • Data Source
      KAKENHI-PROJECT-20K09081
  • [Presentation] Preoperative frailty is associated with poor prognosis after resection for pancreatic cancer2022

    • Author(s)
      Kosuke Mima、Hiromitsu Hayashi, Shigeki Nakagawa, Takashi Matsumoto, Shotaro Kinoshita,Kazuki Matsumura, Fumimasa Kitamura, Norio Uemura, Yosuke Nakao, Rumi Itoyama, Takayoshi Kaida, Katsunori Imai, Yo-ichi Yamashita, Hideo Baba
    • Organizer
      第34回日本肝胆膵外科学会・学術集会
    • Data Source
      KAKENHI-PROJECT-20K09081
  • [Presentation] Cancer associated fibroblast promotes malignant behavior pancreatic cancer by expressing thrombosopondin-1 according to tissue stiffness2022

    • Author(s)
      Kazuki Matsumura、Hiromitsu Hayashi, Norio Uemura, Fumimasa Kitamura, Shigeki Nakagawa, Kosuke Mima, Katsunori Imai, Yo-ichi Yamashita, Hideo Baba
    • Organizer
      第34回日本肝胆膵外科学会・学術集会
    • Data Source
      KAKENHI-PROJECT-20K09081
  • [Presentation] Clinical impact of statin intake and its biological mechanism via YAP/TAZ against hepatobiliary pancreatic cancers2021

    • Author(s)
      Hiromitsu Hayashi, Norio Uemura, Kazuki Matsumura, Zhao Liu, Hirohisa Satou, Yuta Shiraishi, Yuki Kitano, Katsunori Imai, Yo-ichi Yamashita, Hideo Baba
    • Organizer
      日本肝胆膵外科学会
    • Data Source
      KAKENHI-PROJECT-19K09177
  • [Presentation] 肝細胞癌におけるmicrovascular invasionリスクスコアの臨床的有用性に関する検討2020

    • Author(s)
      足立優樹、林洋光、遊佐俊彦、塚本雅代、山尾暢宣、東孝暁、山村謙介、今井克憲、山下洋市、馬場秀夫
    • Organizer
      第120回日本外科学会定期学術集会
    • Data Source
      KAKENHI-PROJECT-20K08984
  • [Presentation] 血小板低値である肝細胞癌における肝切除術の安全性の検討2019

    • Author(s)
      上村 紀雄、今井 克憲、北村 文優、宮田 辰徳、中川 茂樹、岡部 弘尚、林 洋光、山下 洋市、近本 亮、馬場 秀夫
    • Organizer
      第119回 日本外科学会定期学術集会
    • Data Source
      KAKENHI-PROJECT-17K10670
  • [Presentation] 膵癌に対するStatin投 与によるYAP/TAZを介した抗腫瘍効果に関する検討2019

    • Author(s)
      上村紀雄、林洋光、松村和季、 北村文優、伊東山 瑠美、中尾陽佑、山尾宣暢、東孝暁、山村 謙介、今井克憲、近本 亮、山下洋市、馬場秀夫
    • Organizer
      第53回制癌剤適応研究会
    • Data Source
      KAKENHI-PROJECT-19K09177
  • [Presentation] 腹腔鏡下再肝切除の問題点とアプローチ法の工夫2019

    • Author(s)
      林 洋光、山下 洋市、北村 文優、上村 紀雄、中川 茂樹、岡部 弘尚、今井 克憲、近本 亮、高森 啓史、馬場 秀夫
    • Organizer
      第74回 日本消化器外科学会総会
    • Data Source
      KAKENHI-PROJECT-17K10670
  • [Presentation] 膵癌における スタチンのHippo-pathwayを介した抗腫瘍効果2019

    • Author(s)
      上村紀雄、林 洋光、東 孝暁、伊東山瑠美、中尾陽佑、遊佐俊彦、今井克憲、山下洋市、近本 亮、馬場秀夫
    • Organizer
      第30回日本消化器癌発生学会総会
    • Data Source
      KAKENHI-PROJECT-18K08651
  • [Presentation] 膵癌における スタチンのHippo-pathwayを介した抗腫瘍効果2019

    • Author(s)
      上村紀雄、林洋光、東孝暁、伊 東山瑠美、中尾陽佑、遊佐俊彦、今井克憲、山下洋市、近本亮、馬場秀夫
    • Organizer
      第30回日本消化器癌発生学会総会
    • Data Source
      KAKENHI-PROJECT-19K09177
  • [Presentation] 膵癌に対するStatin投 与によるYAP/TAZを介した抗腫瘍効果に関する検討2019

    • Author(s)
      上村紀雄、林 洋光、松村和季、 北村文優、伊東山瑠美、中尾陽佑、山尾宣暢、東 孝暁、山村謙介、今井克憲、近本 亮、山下洋市、馬場秀夫
    • Organizer
      第53回制癌剤適応研究会
    • Data Source
      KAKENHI-PROJECT-18K08651
  • [Presentation] 腫瘍微小環境における炎症性シグナルを介した膵癌進展メカニズムの解明2018

    • Author(s)
      有馬浩太、伊東山瑠美、石本崇胤、三宅慧輔、内原智幸、中川茂樹、岡部弘尚、林洋光、今井克憲、近本亮、山下洋市、馬場秀夫
    • Organizer
      第29回日本消化器癌発生学会総会
    • Data Source
      KAKENHI-PROJECT-18K08651
  • [Presentation] 高難度肝切除を安全に行うための多角的取り組み2018

    • Author(s)
      林 洋光、生田 義明、赤星 慎一、増田 稔郎、緒方 健一、松本 克孝、小川 克大、武山 秀晶、山根 大侍、高森 啓史
    • Organizer
      第118回 日本外科学会定期学術集会
    • Data Source
      KAKENHI-PROJECT-17K10670
  • [Presentation] 腹腔鏡下肝後区域切除のコツとピットホール ~定型化へ向けて~2018

    • Author(s)
      林 洋光、生田義明、増田稔郎、緒方健一、松本克孝、赤星慎一、小川克大、武山秀晶、山根大侍、高森啓史
    • Organizer
      第73回日本消化器外科学会総会
    • Data Source
      KAKENHI-PROJECT-17K10670
  • [Presentation] 高難度肝切除を安全に行うための多角的取り組み2018

    • Author(s)
      林 洋光、生田義明、赤星慎一、増田稔郎、緒方健一、松本克孝、小川克大、武山秀晶、山根大侍、高森啓史
    • Organizer
      第118回日本外科学会定期学術集会
    • Data Source
      KAKENHI-PROJECT-17K10670
  • [Presentation] 肝再生および肝萎縮におけるトロンボスポンディン1の役割解明と臨床応用への探索2017

    • Author(s)
      林 洋光、黒木 秀幸、東 孝暁:、武山 秀晶、岡部 弘尚、今井 克憲、山下 洋市、高森 啓史、馬場 秀夫
    • Organizer
      第117回 日本外科学会定期学術集会
    • Data Source
      KAKENHI-PROJECT-17K10670
  • [Presentation] 肝再生および肝萎縮におけるトロンボスポンディン1の役割解明と臨床応用への探索2017

    • Author(s)
      林洋光、黒木秀幸、東孝暁、武山秀晶、岡部弘尚、今井克憲、山下洋市、高森啓史、馬場秀夫
    • Organizer
      第117回日本外科学会定期学術集会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Data Source
      KAKENHI-PROJECT-26462046
  • [Presentation] Right hemihepatectomy with an anterior approach for advanced hepatocellular carcinoma (Vp3)2017

    • Author(s)
      Hiromitsu Hayashi、Hirohisa Okabe, Yoshiaki Ikuta, Shinichi Akaboshi, Katsuhisa Ogawa, Nobuyuki Ozaki, Kenichi Ogata, Toru Beppu, Hideo Baba, Hiroshi Takamori
    • Organizer
      第6回アジア太平洋肝胆膵学会・第29回日本肝胆膵外科学会学術集会
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K10578
  • [Presentation] 肝再生および肝萎縮におけるトロンボスポンディン1の役割解明と臨床応用への探索2017

    • Author(s)
      林 洋光、黒木秀幸、東 孝暁、武山秀晶、岡部弘尚、今井克憲、山下洋市、高森啓史、馬場秀夫
    • Organizer
      第117回日本外科学会定期学術集会
    • Data Source
      KAKENHI-PROJECT-16K10578
  • [Presentation] 肝細胞癌におけるHippo pathwayを介した癌幹細胞性獲得機構の解明と治療への応用2016

    • Author(s)
      林洋光、高森啓史、馬場秀夫
    • Organizer
      第102回日本消化器病学会総会
    • Place of Presentation
      京王プラザホテル(東京都)
    • Data Source
      KAKENHI-PROJECT-16K10578
  • [Presentation] Hippo-pathwayを介した癌幹細胞性獲得機構の解明と治療への応用2016

    • Author(s)
      林洋光、東孝暁、横山奈穂美、甲斐田剛圭、新田英利、橋本大輔、近本 亮、別府 透、高森啓史、馬場秀夫
    • Organizer
      第116回日本外科学会定期学術集会
    • Place of Presentation
      大阪国際会議場(大阪府)
    • Data Source
      KAKENHI-PROJECT-16K10578
  • [Presentation] 肝切除後の血漿中Thrombospondin-1変化の肝障害の予測因子としての可能性2016

    • Author(s)
      黒木秀幸、林洋光、中川茂樹、東孝暁、橋本大輔、新田英利、近本 亮、石河隆敏、別府 透、馬場秀夫
    • Organizer
      第116回日本外科学会定期学術集会
    • Place of Presentation
      大阪国際会議場(大阪府)
    • Data Source
      KAKENHI-PROJECT-26462046
  • [Presentation] Hippo-pathwayを介した癌幹細胞性獲得機構の解明と治療への応用2016

    • Author(s)
      林洋光、東孝暁、横山奈穂美、甲斐田剛圭、新田英利、橋本大輔、近本 亮、別府 透、高森啓史、馬場秀夫
    • Organizer
      第116回日本外科学会定期学術集会
    • Place of Presentation
      大阪国際会議場(大阪府)
    • Data Source
      KAKENHI-PROJECT-26462046
  • [Presentation] 肝切除後の血漿中Thrombospondin-1変化の肝障害の予測因子としての可能性2016

    • Author(s)
      黒木秀幸、林洋光、中川茂樹、東孝暁、橋本大輔、新田英利、近本 亮、石河隆敏、別府 透、馬場秀夫
    • Organizer
      第116回日本外科学会定期学術集会
    • Place of Presentation
      大阪国際会議場(大阪府)
    • Data Source
      KAKENHI-PROJECT-15K19898
  • [Presentation] スタチン内服による肝細胞癌に対する肝切除後再発抑制効果に関する検討2015

    • Author(s)
      東 孝暁、林洋光、武山秀晶、有馬浩太、甲斐田剛圭、高城克暢、坂本慶太、坂田和也、岡部弘尚、新田英利、橋本大輔、近本亮、別府透、馬場秀夫
    • Organizer
      第115回日本外科学会定期学術集会
    • Place of Presentation
      名古屋国際会議場(愛知県)
    • Year and Date
      2015-04-18
    • Data Source
      KAKENHI-PROJECT-26861088
  • [Presentation] TSP-1 を介したTGF-β活性化機構抑制による肝切除術後の肝再生促進療法2015

    • Author(s)
      黒木秀幸、林洋光、中川茂樹、東孝暁、橋本大輔、新田英利、近本亮、石河隆敏、別府透、馬場秀夫
    • Organizer
      第27回日本肝胆膵外科学会・学術集会
    • Place of Presentation
      ホテルグランパシフィック LE DAIBA(東京都)
    • Year and Date
      2015-06-12
    • Data Source
      KAKENHI-PROJECT-26861088
  • [Presentation] TSP-1 を介したTGF-β活性化による肝再生抑制機構をターゲットとした新規肝再生促進療法の開発2014

    • Author(s)
      黒木 秀幸, 林 洋光, 中川 茂樹, 東 孝暁, 橋本 大輔, 阿部 真也, 新田 英利, 近本 亮, 石河 隆敏, 別府 透, 馬場 秀夫
    • Organizer
      第114回日本外科学会定期学術集会
    • Place of Presentation
      国立京都国際会館
    • Year and Date
      2014-04-03
    • Data Source
      KAKENHI-PROJECT-24791434
  • [Presentation] Integrin beta6 はTGF-beta による上皮間葉転換を促進し肝内胆管癌の進展に関与する2014

    • Author(s)
      東 孝暁, 林 洋光, 黒木 秀幸, 中川 茂樹, 坂本 慶太, 横山 奈穂美, 新田 英利, 近本亮, 別府 透, 馬場 秀夫
    • Organizer
      第114回日本外科学会定期学術集会
    • Place of Presentation
      国立京都国際会館
    • Year and Date
      2014-04-03
    • Data Source
      KAKENHI-PROJECT-24791434
  • [Presentation] 肝再生抑制因子トロンボスポンディン1 に対する阻害ペプチドを用いた肝再生促進療法2014

    • Author(s)
      林 洋光
    • Organizer
      第50回日本肝臓学会総会
    • Place of Presentation
      ホテルニューオータニ(東京都)
    • Year and Date
      2014-05-29
    • Data Source
      KAKENHI-PROJECT-24791434
  • [Presentation] Clinical significance of residual proliferative activity in conversion therapy for colorectal liver-confined metastasis2014

    • Author(s)
      Hayashi H
    • Organizer
      SISSO2014
    • Place of Presentation
      Grand Hilton Seoul Hotel,Seoul,Korea
    • Data Source
      KAKENHI-PROJECT-24592034
  • [Presentation] TAZ (WWTR1), a key transcription co-activator of hippo-pathway, promotes hepatocellular carcinoma progression via PI3K/Akt/mTOR pathway2014

    • Author(s)
      Hiromitsu Hayashi, Hideyuki Kuroki, Shigeki Nakagawa, Takaaki Higashi, Keita Sakamoto, Naomi Yokoyama, Takatoshi Ishiko, Toru Beppu, Hideo Baba.
    • Organizer
      AACR 2014
    • Place of Presentation
      San Diego
    • Data Source
      KAKENHI-PROJECT-25462098
  • [Presentation] LSKL peptide inhibits thrombospondin-1- mediated TGF-β signal activation and accelerates liver regeneration after hepatectomy in mice2014

    • Author(s)
      Kuroki H, Hayashi H, Nakagawa S, Sakamoto K, Higashi T, Nitta H, Hashimoto D, Chikamoto A, Beppu T, Baba H
    • Organizer
      AACR Annual Meeting 2014
    • Place of Presentation
      San Diego, California, USA
    • Year and Date
      2014-04-07
    • Data Source
      KAKENHI-PROJECT-24791434
  • [Presentation] TGF-β活性化による肝再生抑制機構の解明と活性化阻害peptide を用いた肝再生促進療法開発2013

    • Author(s)
      林 洋光, 黒木 秀幸, 美馬 浩介, 中川 茂樹, 新田 英利, 今井 克憲, 蔵元 一崇, 近本 亮, 別府 透, 馬場 秀夫
    • Organizer
      第25回日本肝胆膵外科学会学術集会
    • Place of Presentation
      ホテル東日本宇都宮(栃木県)
    • Year and Date
      2013-06-12
    • Data Source
      KAKENHI-PROJECT-24791434
  • [Presentation] TGF β 活性化機構による肝再生抑制機構の解明と新戦略の構築2013

    • Author(s)
      林洋光、黒木秀幸、美馬浩介 、中川茂樹 、新田英利 、今井克憲 、蔵元一崇 、近本 亮 、別府 透 、酒井尚雄、馬場秀夫
    • Organizer
      第113回日本外科学会
    • Place of Presentation
      マリンメッセ福岡
    • Data Source
      KAKENHI-PROJECT-24791434
  • [Presentation] TGF-β活性化による肝再生抑制機構の解明と活性化阻害peptideを用いた肝再生促進療法開発2013

    • Author(s)
      林洋光、黒木秀幸、美馬浩介、中川茂樹、新田英利、今井克憲、蔵元一崇、近本 亮、別府 透、馬場秀夫
    • Organizer
      第25回日本肝胆膵外科学会・学術集会
    • Place of Presentation
      ホテル東日本宇都宮
    • Data Source
      KAKENHI-PROJECT-24791434
  • [Presentation] TGF β活性化機構による肝再生抑制機構の解明と新戦略の構築2013

    • Author(s)
      林 洋光, 黒木 秀幸, 美馬 浩介, 中川 茂樹, 新田 英利, 今井 克憲, 蔵元 一崇, 近本 亮, 別府 透, 酒井 尚雄, 馬場 秀夫
    • Organizer
      第113回日本外科学会学術集会
    • Place of Presentation
      マリンメッセ福岡
    • Year and Date
      2013-04-11
    • Data Source
      KAKENHI-PROJECT-24791434
  • [Presentation] 肝再生抑制機構の解明と新規標的トロンボスポンディン1の同定2012

    • Author(s)
      林 洋光
    • Organizer
      第112回日本外科学会定期学術集会
    • Place of Presentation
      千葉 幕張メッセ国際会議場
    • Data Source
      KAKENHI-PROJECT-24791434
  • [Presentation] 肝再生抑制機構の解明と新規標的トロンボスポンディン1 の同定2012

    • Author(s)
      林 洋光
    • Organizer
      第112回日本外科学会学術集会
    • Place of Presentation
      幕張メッセ国際会議場(千葉県)
    • Data Source
      KAKENHI-PROJECT-24791434
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