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DOI Shigehiro
土井 盛博
Researcher Number
80626127
Other IDs
https://orcid.org/0000-0001-9420-4124
Affiliation (based on the past Project Information)
*help
2017 – 2022: 広島大学, 病院(医), 助教
2018: 広島大学, 病院(医), 病院助教
2015 – 2016: 広島大学, 病院(医), 病院助教
2014: 広島大学, 大学病院, 病院助教
2014: 広島大学病院, 助教
Review Section/Research Field
Principal Investigator
Basic Section 53040:Nephrology-related
/
Kidney internal medicine
Except Principal Investigator
Kidney internal medicine
/
Basic Section 53040:Nephrology-related
Keywords
Principal Investigator
虚血再灌流障害 / ヒストンバリアント / ヒストン修飾 / エピジェネティクス / 腎虚血再灌流障害 / 虚血再灌流 / アルドステロン / 食塩 / 上皮ナトリウムチャンネル / 食塩感受性高血圧
…
More
/ ミネラルコルチコイドレセプター / 急性腎障害 / 腎線維化 / ヒストンメチル化酵素 / ヒストンメチル化 / 線維化 / p16 / 老化 / Acute kidney injury / Senescence / p16INK4a / H3K4me3 / WDR5 / MLL1
…
More
Except Principal Investigator
線維化 / 腎線維化 / 間葉系幹細胞 / 抗炎症作用 / 再生医療 / マクロファージ / 無血清培地 / 生着 / 生着期間 / ステロイド / IFN-γ / 炎症細胞 / 治療効果 / 免疫抑制薬 / B cell lymphoma-2 / 急性腎障害 / P53 / 低酸素 / survivin / p53 / 炎症細胞浸潤 / 生存率 / 心筋梗塞 / アポトーシス / DEC1 / 時計遺伝子 / エピジェネティック / エピジェネティクス / HIRA / ヒストンシャペロン / H3.3 / ヒストンバリアント / ESKD / CKD / 老化 / ストレス誘導性老化
Less
Research Projects
(
8
results)
Research Products
(
8
results)
Co-Researchers
(
8
People)
Project Start Year (Newest)
Project Start Year (Oldest)
Effect of DEC1 on renal fibrosis and apoptosis induced by ischemia reperfusion injury
Principal Investigator
Nakashima Ayumu
Project Period (FY)
2020 – 2022
Research Category
Grant-in-Aid for Scientific Research (C)
Review Section
Basic Section 53040:Nephrology-related
Research Institution
Hiroshima University
Effect of mesenchymal stem cells on renal fibrosis: Combination with immunosuppressive therapy
Principal Investigator
Masaki Takao
Project Period (FY)
2020 – 2022
Research Category
Grant-in-Aid for Scientific Research (C)
Review Section
Basic Section 53040:Nephrology-related
Research Institution
Hiroshima University
Upregulation of mineralocorticoid receptor contributes to development of salt-sensitive hypertension after ischemic reperfusion injury in rats
Principal Investigator
Principal Investigator
Doi Shigehiro
Project Period (FY)
2019 – 2021
Research Category
Grant-in-Aid for Scientific Research (C)
Review Section
Basic Section 53040:Nephrology-related
Research Institution
Hiroshima University
Supression of stress-induced senescene in kidney by transplantation of mesenchymal stem cells
Principal Investigator
Masaki Takao
Project Period (FY)
2017 – 2019
Research Category
Grant-in-Aid for Scientific Research (C)
Research Field
Kidney internal medicine
Research Institution
Hiroshima University
Inhibition of JMJD3 attenuate renal senescense in ischemic reperfusion mice
Principal Investigator
Principal Investigator
Doi Shigehiro
Project Period (FY)
2016 – 2018
Research Category
Grant-in-Aid for Scientific Research (C)
Research Field
Kidney internal medicine
Research Institution
Hiroshima University
TGF-beta promotes expression of fibrosis-related genes through the induction of histone variant H3.3 and histone chaperone HIRA
Principal Investigator
Kensuke Sasaki
Project Period (FY)
2016 – 2017
Research Category
Grant-in-Aid for Young Scientists (B)
Research Field
Kidney internal medicine
Research Institution
Hiroshima University
Mesenchymal stem cells cultured in serum-free medium ameliorate experimental renal fibrosis.
Principal Investigator
MASAKI TAKAO
Project Period (FY)
2014 – 2016
Research Category
Grant-in-Aid for Scientific Research (C)
Research Field
Kidney internal medicine
Research Institution
Hiroshima University
The therapeutic effect of mesenchymal stem cells cultured under serum-free media on kidney diseases: to apply them to clinical application
Principal Investigator
UENO TOSHINORI
Project Period (FY)
2013 – 2014
Research Category
Grant-in-Aid for Young Scientists (B)
Research Field
Kidney internal medicine
Research Institution
Hiroshima University
All
2019
2018
2017
2016
All
Presentation
Patent
[Patent] 生体組織損傷の修復剤および当該修復剤の製造方法
2016
Inventor(s)
中島歩、正木崇生、土井盛博、吉田健、加藤幸夫、辻紘一郎
Industrial Property Rights Holder
中島歩、正木崇生、土井盛博、吉田健、加藤幸夫、辻紘一郎
Industrial Property Rights Type
特許
Industrial Property Number
2016-256779
Filing Date
2016-12-28
Data Source
KAKENHI-PROJECT-26461229
[Presentation] Hypoxia-Preconditioned Mesenchymal Stem Cells Prevent AKI to CKD
2019
Author(s)
石内直樹、中島歩、土井盛博、金井亮、土井俊樹、正木崇生
Organizer
American Society of Nephrology Kidney Week 2019
Int'l Joint Research
Data Source
KAKENHI-PROJECT-17K09699
[Presentation] Mesenchymal Stem Cells Cultured in IFN-γ-Containing Medium Ameliorate Experimental Renal Fibrosis
2019
Author(s)
金井亮、中島歩、土井盛博、石内直樹、土井俊樹、正木崇生
Organizer
American Society of Nephrology Kidney Week 2019（
Int'l Joint Research
Data Source
KAKENHI-PROJECT-17K09699
[Presentation] H3K4 Methyltransferase Inhibitor MM-102 Attenuates Renal Senescence in Ischemic Reperfusion Mice Through Reduction of p16INK4a
2018
Author(s)
Hironori Shimoda, Shigehiro Doi, Ayumu Nakashima, Kensuke Sasaki, Toshiki Doi, Takao Masaki
Organizer
Annual Meeting of American Society of Nephrology
Int'l Joint Research
Data Source
KAKENHI-PROJECT-16K09618
[Presentation] H3K4メチル化酵素阻害剤MM-102は、p16INK4aの発現を抑制し、腎の炎症と線維化を改善する
2018
Author(s)
下田大紀、 土井盛博 、 土井俊樹 、 中島歩 、 正木崇生
Organizer
日本腎臓学会
Data Source
KAKENHI-PROJECT-16K09618
[Presentation] Mesenchymal stem cells cultured in serum-free medium ameliorate experimental renal fibrosis by their strong immunosuppressive effects
2017
Author(s)
吉田健、中島歩、土井盛博、上野敏憲、加藤幸夫、東幸仁、正木崇生
Organizer
Kidney Week: American Society of Nephrology
Int'l Joint Research
Data Source
KAKENHI-PROJECT-17K09699
[Presentation] TGF-β1 promotes fibrotic gene expression through the induction of histone variant
2017
Author(s)
Toshihiro Shindo, Shigehiro Doi, Kensuke Sasaki, Ayumu Nakashima, Takao Masaki
Organizer
ISN frontier
Int'l Joint Research
Data Source
KAKENHI-PROJECT-16K19489
[Presentation] TGF-β1 promotes fibrotic gene expression through the induction of histone variant
2017
Author(s)
Toshihiro Shindo, Shigehiro Doi, Kensuke Sasaki, Ayumu Nakashima, Takao Masaki
Organizer
米国腎臓学会2017
Int'l Joint Research
Data Source
KAKENHI-PROJECT-16K19489
# of Projects (Dsc)
# of Projects (Asc)
1.
MASAKI Takao
(30397913)
# of Collaborated Projects:
8 results
# of Collaborated Products:
7 results
2.
NAKASHIMA Ayumu
(40448262)
# of Collaborated Projects:
8 results
# of Collaborated Products:
7 results
3.
UENO TOSHINORI
(50646891)
# of Collaborated Projects:
2 results
# of Collaborated Products:
0 results
4.
Kensuke Sasaki
(40770326)
# of Collaborated Projects:
2 results
# of Collaborated Products:
3 results
5.
KATO YUKIO
(10112062)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
6.
東 幸仁
(40346490)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
7.
河本 健
(50224861)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
8.
SHIMODA Hironori
# of Collaborated Projects:
1 results
# of Collaborated Products:
2 results
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