DOUMOTO Takahiro 堂本貴寛

… Alternative Names

Domoto Takahiro 堂本貴寛

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Researcher Number	80635540
Other IDs
External Links
Affiliation (Current)	2025: 金沢大学, がん進展制御研究所, 助教
Affiliation (based on the past Project Information) *help	2025: 金沢大学, がん進展制御研究所, 助教 2013 – 2023: 金沢大学, がん進展制御研究所, 助教
Review Section/Research Field	Principal Investigator Basic Section 50020:Tumor diagnostics and therapeutics-related / Tumor therapeutics / Pathological medical chemistry Except Principal Investigator Digestive surgery
Keywords	Principal Investigator GSK3β / 分子標的治療 / がん代謝 / がん幹細胞 / 浸潤 / 獲得耐性 / オートファジー / リン酸化 / がん幹細胞性 / 薬剤耐性 / 乳酸 / 大腸がん / GSK3beta … More Except Principal Investigator … More 大腸がん / 治療 / 病態 / 核膜孔複合体 / 核移送 / β-カテニン Less

治療耐性膵がんの悪性進展ネットワークの解明と治療法開発への応用Principal Investigator
- Principal Investigator
  
  堂本貴寛
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Kanazawa University
抗がん剤耐性獲得膵がん細胞における悪性形質連関の解明と治療法開発Principal Investigator
- Principal Investigator
  
  堂本貴寛
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Kanazawa University
Exploring the characteristics of tumor-promoting glycometabolism enhanced by GSK3beta toward application to cancer therapy.Principal Investigator
- Principal Investigator
  
  Domoto Takahiro
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Kanazawa University
Exploring biological basis of aberrant cancer energy metabolism induced by GSK3beta toward application to cancer treatmentPrincipal Investigator
- Principal Investigator
  
  DOMOTO TAKAHIRO
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Tumor therapeutics
- Research Institution
  Kanazawa University
Identification and functional analysis of nuclear pore complex components that function to transport beta-catenin between cytoplasm and nucleus
- Principal Investigator
  
  Minamoto Toshinari
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Digestive surgery
- Research Institution
  Kanazawa University
Investigation of biological basis of GSK3beta-targeted therapy and its translation to colorectal cancer treatment
- Principal Investigator
  
  MINAMOTO Toshinari
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Digestive surgery
- Research Institution
  Kanazawa University
Exploring biological basis of aberrant energy metabolic property of gastrointestinal cancer toward application to cancer treatmentPrincipal Investigator
- Principal Investigator
  
  Domoto Takahiro
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Kanazawa University

All 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 Other

All Journal Article Presentation Book

[Book] 肝胆膵「膵がんの増殖，浸潤と治療不応性を繋ぐ治療標的GSK3β」2017
- Author(s)
  島崎猛夫，堂本貴寛，宮下知治，中田光俊，元雄良治，太田哲生，源利成
- Total Pages
  7
- Publisher
  アークメディア
- Data Source
  KAKENHI-PROJECT-17K15022
[Journal Article] Glycogen synthase kinase 3β: the nexus of chemoresistance, invasive capacity, and cancer stemness in pancreatic cancer2024
- Author(s)
  Masahiro Uehara, Takahiro Domoto, Satoshi Takenaka, Osamu Takeuchi, Takeo Shimasaki, Tomoharu Miyashita, Toshinari Minamoto
- Journal Title
  
  Cancer Drug Resist .
  
  Volume: 7 Pages: 4-4
- DOI
  10.20517/cdr.2023.84
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K07227, KAKENHI-PROJECT-23K24403
[Journal Article] Deactivation of GSK3β by heat shock inducible tumor small protein (HITS, FAM107B) attenuates hyperthermia-induced pro-migratory activity in colorectal cancer cells2023
- Author(s)
  Keita Koizumi, Takahiro Domoto, Toshinari Minamoto, Kazuhito Satomura, Hideo Nakajima
- Journal Title
  
  Int J Oncol.
  
  Volume: 63 Issue: 2 Pages: 92-92
- DOI
  10.3892/ijo.2023.5540
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K07227, KAKENHI-PROJECT-23K24403
[Journal Article] Discovery of a Novel Aminocyclopropenone Compound That Inhibits BRD4-Driven Nucleoporin NUP210 Expression and Attenuates Colorectal Cancer Growth2022
- Author(s)
  Kondo Hiroya、Mishiro Kenji、Iwashima Yuki、Qiu Yujia、Kobayashi Akiko、Lim Keesiang、Domoto Takahiro、Minamoto Toshinari、Ogawa Kazuma、Kunishima Munetaka、Hazawa Masaharu、Wong Richard W.
- Journal Title
  
  Cells
  
  Volume: 11 Issue: 3 Pages: 317-317
- DOI
  10.3390/cells11030317
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07398, KAKENHI-PROJECT-19K07710, KAKENHI-PROJECT-20K15953, KAKENHI-PROJECT-19H03727, KAKENHI-PROJECT-20K16262, KAKENHI-PUBLICLY-21H05744, KAKENHI-PUBLICLY-22H05537, KAKENHI-PROJECT-21K19043, KAKENHI-PROJECT-23K24403, KAKENHI-PROJECT-23K23476
[Journal Article] Potential therapeutic effect of targeting glycogen synthase kinase 3β in esophageal squamous cell carcinoma2020
- Author(s)
  Dilireba Bolidong, Takahiro Domoto, Masahiro Uehara, Hemragul Sabit, Tomoyuki Okumura, Yoshio Endo, Mitsutoshi Nakada, Itasu Ninomiya, Tomoharu Miyashita, Richard W Wong, Toshinari Minamoto
- Journal Title
  
  Scientific Reports
  
  Volume: 10 Issue: 1 Pages: 11807-11807
- DOI
  10.1038/s41598-020-68713-9
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07710, KAKENHI-PROJECT-19H03727
[Journal Article] Glycogen synthase kinase 3β in cancer biology and treatment.2020
- Author(s)
  Takahiro Domoto, Masahiro Uehara, Dilireba Bolidong, Toshinari Minamoto
- Journal Title
  
  Cells
  
  Volume: 9 Issue: 6 Pages: 1388-1388
- DOI
  10.3390/cells9061388
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07710, KAKENHI-PROJECT-19H03727
[Journal Article] Glycogen synthase kinase-3β participates in acquired resistance to gemcitabine in pancreatic cancer2020
- Author(s)
  Masahiro Uehara, Takahiro Domoto, Satoshi Takenaka, Dilireba Bolidong, Osamu Takeuchi, Tomoharu Miyashita, Toshinari Minamoto
- Journal Title
  
  Cancer Science
  
  Volume: 111 Issue: 12 Pages: 4405-4416
- DOI
  10.1111/cas.14668
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07710, KAKENHI-PROJECT-19H03727
[Journal Article] Glycogen synthase kinase 3β as a potential therapeutic target in synovial sarcoma and fibrosarcoma2019
- Author(s)
  Abe Kensaku、Yamamoto Norio、Domoto Takahiro、Bolidong Dilireba、Hayashi Katsuhiro、Takeuchi Akihiko、Miwa Shinji、Igarashi Kentaro、Inatani Hiroyuki、Aoki Yu、Higuchi Takashi、Taniguchi Yuta、Yonezawa Hirotaka、Araki Yoshihiro、Aiba Hisaki、Minamoto Toshinari、Tsuchiya Hiroyuki
- Journal Title
  
  Cancer Science
  
  Volume: 111 Issue: 2 Pages: 429-440
- DOI
  10.1111/cas.14271
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K09058, KAKENHI-PROJECT-19K07710, KAKENHI-PROJECT-19K09571, KAKENHI-PROJECT-16K10850, KAKENHI-PROJECT-18K19577, KAKENHI-PROJECT-19H03727
[Journal Article] Identification of GSK3β inhibitor kenpaullone as a temozolomide enhancer against glioblastoma2019
- Author(s)
  Kitabayashi Tomohiro、Dong Yu、Furuta Takuya、Sabit Hemragul、Jiapaer Shabierjiang、Zhang Jiakang、Zhang Guangtao、Hayashi Yasuhiko、Kobayashi Masahiko、Domoto Takahiro、Minamoto Toshinari、Hirao Atsushi、Nakada Mitsutoshi
- Journal Title
  
  Scientific Reports
  
  Volume: 9 Issue: 1 Pages: 10049-10049
- DOI
  10.1038/s41598-019-46454-8
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07710, KAKENHI-PROJECT-19H01033, KAKENHI-PROJECT-19H03727, KAKENHI-PROJECT-17K07160, KAKENHI-PROJECT-18H02910, KAKENHI-PROJECT-18K19577
[Journal Article] Colorectal cancer cells require glycogen synthase kinase-3β for sustaining mitosis via translocated promoter region (TPR)-dynein interaction2018
- Author(s)
  Dewi Firli R.P.、Domoto Takahiro、Hazawa Masaharu、Kobayashi Akiko、Douwaki Takayuki、Minamoto Toshinari、Wong Richard W.
- Journal Title
  
  Oncotarget
  
  Volume: 9 Issue: 17 Pages: 13337-52
- DOI
  10.18632/oncotarget.24344
- NAID
  120006452368
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K15022, KAKENHI-PROJECT-17K16332, KAKENHI-PROJECT-18K19577
[Journal Article] 膵がんの増殖，浸潤と治療不応性を繋ぐ治療標的GSK3β．2017
- Author(s)
  島崎猛夫，堂本貴寛，宮下知治，中田光俊，元雄良治，太田哲生，源利成．
- Journal Title
  
  肝胆膵
  
  Volume: 75 Pages: 769-75
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15H04928
[Journal Article] Glycogen synthase kinase 3β is a pivotal mediator in cancer invasion and resistance to therapy.2016
- Author(s)
  Domoto T, et al, Minamoto T.
- Journal Title
  
  Cancer Sci
  
  Volume: 107 Issue: 10 Pages: 1363-72
- DOI
  10.1111/cas.13028
- NAID
  120005895690
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04928, KAKENHI-PROJECT-26293322, KAKENHI-PROJECT-15K15493, KAKENHI-PROJECT-16K19996
[Journal Article] Tip60 regulates MT1-MMP transcription and invasion of glioblastoma cells through NF-κB pathway.2016
- Author(s)
  Takahisa Takino, Mitsutoshi Nakada, Zichen Li, Taisuke Yoshimoto, Takahiro Domoto, Hiroshi Sato.
- Journal Title
  
  Clin Exp Metastasis
  
  Volume: 33 Pages: 45-52
- NAID
  120005680038
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25860233
[Journal Article] Glycogen synthase kinase 3β sustains invasion of glioblastoma via the focal adhesion kinase, Rac1 and c-Jun N-terminal kinase-mediated pathway.2015
- Author(s)
  Chikano Y, Domoto T, Furuta T, Sabit H, Kitano-Tamura A, Ilya V. Pyko, Takino T, Sai Y, Hayashi Y, Sato H, Miyamoto K, Nakada M, MinamotoT.
- Journal Title
  
  Molecular Cancer Therapeutics
  
  Volume: 14 Issue: 2 Pages: 564-574
- DOI
  10.1158/1535-7163.mct-14-0479
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25460382, KAKENHI-PROJECT-25670572, KAKENHI-PROJECT-25860233, KAKENHI-PROJECT-26293322, KAKENHI-PROJECT-26670638, KAKENHI-PROJECT-26893096, KAKENHI-PROJECT-15K15493, KAKENHI-PROJECT-15H04928
[Journal Article] Membrane-type 1 matrix metalloproteinase regulates fibronectin assembly and N-cadherin adhesion.2014
- Author(s)
  Takino T, Yoshimoto T, Nakada M, Li Z, Domoto T, Kawashiri S, Sato H.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: ４５０ Issue: 2 Pages: 1016-1020
- DOI
  10.1016/j.bbrc.2014.06.100
- NAID
  120005478703
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460382, KAKENHI-PROJECT-25860233, KAKENHI-PROJECT-26293322, KAKENHI-PROJECT-26670861
[Journal Article] Vinculin negatively regulates transcription of MT1-MMP through MEK/ERK pathway.2014
- Author(s)
  Yoshimoto T, Takino T, Li Z, Domoto T, Sato H
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 455 Issue: 3-4 Pages: 251-255
- DOI
  10.1016/j.bbrc.2014.10.154
- NAID
  120005537877
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460382, KAKENHI-PROJECT-25860233
[Presentation] Overexpression of Cyclin D2 in Gemcitabine-Resistant Pancreatic Cancer and its Potential as a Therapeutic Target2023
- Author(s)
  Uehara Masahiro, Satoshi Takenaka, Domoto Takahiro, Horike Shinichi, Takahashi Chiaki, Tomoharu Miyashita, Minamoto Toshinari
- Organizer
  第82回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-22K07227
[Presentation] A new preclinical GSK3β inhibitor overcomes acquired resistance to gemcitabine in pancreatic cancer2023
- Author(s)
  Takahiro Domoto, Masahiro Uehara, Satoshi Takenaka, Tomoharu Miyashita, Toshinari Minamoto
- Organizer
  第82回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-22K07227
[Presentation] Potential therapeutic effect of preclinical GSK3β inhibitor in pancreatic cancer with resistance to gemcitabine2023
- Author(s)
  Takahiro Domoto, Masahiro Uehara, Ludimila Cavalcante, Frank Giles, Tomoharu Miyashita, Toshinari Minamoto
- Organizer
  第34回日本消化器癌発生学会総会
- Data Source
  KAKENHI-PROJECT-22K07227
[Presentation] 膵がんにおけるゲムシタビン耐性克服のためのcyclin D2関連経路の標的化2023
- Author(s)
  上原将大、竹中哲、堂本貴寛、堀家慎一、高橋智聡、宮下知治、源利成
- Organizer
  第34回日本消化器癌発生学会総会
- Data Source
  KAKENHI-PROJECT-22K07227
[Presentation] Glycogen synthase kinase (GSK)-3β participates in acquired resistance to gemcitabine in pancreatic cancer2022
- Author(s)
  Masahiro Uehara, Takahiro Domoto, Satoshi Takenaka, Dilireba Bolidong, Osamu Takeuchi, Tomoharu Miyashita, Toshinari Minamoto.
- Organizer
  The 7th JCA-AACR Special Joint Conference The Latest Advances in Pancreatic Research: From Basic Science to Therapeutics
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K07227
[Presentation] GSK3β participates in malignant properties of pancreatic cancer acquiring chemoresistance2022
- Author(s)
  Takahiro Domoto, Satoshi Takenaka, Masahiro Uehara, Tatsuhiko Furukawa, Tomoharu Miyashita, Toshinari Minamoto
- Organizer
  第81回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-22K07227
[Presentation] GSK3β integrates acquired chemoresistance, invasive capacity and tumor stemness in refractory pancreatic cancer2022
- Author(s)
  Takahiro Domoto, Masahiro Uehara, Tomoharu Miyashita, Toshinari Minamoto
- Organizer
  第33回日本消化器癌発生学会総会
- Data Source
  KAKENHI-PROJECT-22K07227
[Presentation] Efficacy of preclinical GSK3β and clinical CDK4/6 inhibitors against acquired chemoresistance in pancreatic cancer: preliminary observation2022
- Author(s)
  Masahiro Uehara, Takahiro Domoto, Shin-ichi Horike, Francis Giles, Ludimila Cavalcante, Chiaki Takahashi, Toshinari Minamoto
- Organizer
  第33回日本消化器癌発生学会総会
- Data Source
  KAKENHI-PROJECT-22K07227
[Presentation] GSK3βは膵がんのゲムシタビン獲得耐性に寄与する2022
- Author(s)
  上原将大、堂本貴寛、竹中哲、ディリラバボリドン、竹内修、宮下知治、源利成
- Organizer
  第31回日本癌病態治療研究会
- Data Source
  KAKENHI-PROJECT-22K07227
[Presentation] GSK3β interconnects tumor invasion and stemness in pancreatic cancer acquiring resistance to gemcitabine2022
- Author(s)
  Takahiro Domoto, Masahiro Uehara, Osamu Takeuchi, Tomoharu Miyashita, Toshinari Minamoto
- Organizer
  The 7th JCA-AACR Special Joint Conference The Latest Advances in Pancreatic Research: From Basic Science to Therapeutics
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K07227
[Presentation] Glycogen synthase kinase (GSK) 3β participates in acquired resistance to gemcitabine in pancreatic cancer2021
- Author(s)
  Masahiro Uehara, Takahiro Domoto, Satoshi Takenaka, Dilireba Bolidong, Osamu Takeuchi, Tomoharu Miyashita, Toshinari Minamoto.
- Organizer
  The 10th International Conference of the International Society of Gastroenterological Carcinogenesis (ISGC)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07710
[Presentation] GSK3β interconnects the malignant properties in therapy-resistant pancreatic cancer2021
- Author(s)
  Takahiro Domoto, Masahiro Uehara, Satoshi Takenaka, Dilireba Bolidong, Tatsuhiko Furukawa, Osamu Takeuchi, Tomoharu Miyashita, Toshinari Minamoto
- Organizer
  The 10th International Conference of the International Society of Gastroenterological Carcinogenesis (ISGC)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07710
[Presentation] Glycogen synthase kinase (GSK)3β renders pancreatic cancer acquiring resistance to gemcitabine via STAT3 activation2021
- Author(s)
  Takahiro Domoto, Satoshi Takenaka, Masahiro Uehara, Dilireba Bolidong, Tatsuhiko Furukawa, Tomoharu Miyashita, Toshinari Minamoto
- Organizer
  第80回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-19K07710
[Presentation] Potential therapeutic effect of targeting glycogen syntase kinase (GSK)3β in esophageal squamous cell carcinoma (ESCC)2021
- Author(s)
  Dilireba Bolidong, Takahiro Domoto, Masahiro Uehara, Hemragul Sabit, Tomoyuki Okumura, Yoshio Endo, Mitutoshi Nakada, Tomoharu Miyashita, Richard W. Wong, Toshinari Minamoto
- Organizer
  The 10th International Conference of the International Society of Gastroenterological Carcinogenesis (ISGC)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07710
[Presentation] Glycogen synthase kinase (GSK)-3β as a new target to overcome acquired resistance to gemcitabine in pancreatic cancer2020
- Author(s)
  Masahiro Uehara, Takahiro Domoto, Satoshi Takenaka, Diliraba Bolidong, Takeo Shimasaki, Tomoharu Miyashita, Tetsuo Ohta, Toshinari Minamoto
- Organizer
  第79回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-19K07710
[Presentation] GSK3βは膵がんのゲムシタビン耐性獲得に寄与する2020
- Author(s)
  上原将大，堂本貴寛，竹中哲，ディリラバ　ボリドン，竹内　修，宮下知治，源利成
- Organizer
  第31回日本消化器癌発生学会総会
- Data Source
  KAKENHI-PROJECT-19K07710
[Presentation] Role of GSK3β in malignant progression of pancreatic cancer associated with gemcitabine resistance.2020
- Author(s)
  堂本貴寛, 宮下知治, Bolidong Dilireba, 上原将大, 竹中哲, 竹内修, 太田哲生, 源利成
- Organizer
  第29回日本がん転移学会学術集会・総会
- Data Source
  KAKENHI-PROJECT-19K07710
[Presentation] GSK3β interconnects cancer stemness and invasive capacity in pancreatic cancer with acquired resistance to gemcitabine2020
- Author(s)
  Takahiro Domoto, Tomoharu Miyashita, Satoshi Takenaka, Masahiro Uehara, Dilireba Bolidong, Tetsuo Ohta, Toshinari Minamoto
- Organizer
  第79回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-19K07710
[Presentation] GSK3β participates in tumor-promoting metabolism in colon cancer2018
- Author(s)
  Takahiro Domoto, Toshinari Minamoto
- Organizer
  第29回日本消化器癌発生学会総会
- Invited
- Data Source
  KAKENHI-PROJECT-17K15022
[Presentation] Involvement of aberrant GSK3β in tumor-promoting autophagy in colorectal cancer2018
- Author(s)
  Takahiro Domoto, Toshinari Minamoto
- Organizer
  The 13th International Symposium of the Institute Network for Biomedical Sciences
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K15022
[Presentation] Glycogen synthase kinase (GSK) 3β induces protooncogenic autophagy in colon cancer2018
- Author(s)
  Takahiro Domoto, Ilya V. Pyko, Dilireba Bolidong, Masahiro Uehara, Toshinari Minamoto
- Organizer
  第77回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-17K15022
[Presentation] Novel molecular therapy targeting aberrant glycogen synthase kinase-3β in soft tissue sarcoma: a basic research2018
- Author(s)
  Kensaku Abe, Norio Yamamoto, Takahiro Domoto, Katsuhiro Hayashi, Akihiko Takeuchi, Kentaro Igarashi, Yuta Taniguchi, Hirotaka Yonezawa, Yoshihiro Araki, Toshinari Minamoto, Hiroyuki Tsuchiya
- Organizer
  19th EFORT Annual Congress Barcelona 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K15022
[Presentation] Influence of anti-cancer drug against exosome dynamics in pancreatic cancer cells2017
- Author(s)
  Takeo Shimasaki, Satoko Yamamoto, Takahiro Domoto, Etsuko Kiyokawa, Tomiyasu Arisawa, Toshinari Minamoto
- Organizer
  第76回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-17K15022
[Presentation] 膵がん治療耐性に伴う幹細胞性とGSK3β/STAT3経路の機能解析2017
- Author(s)
  竹中哲, 宮下知治, 上原将大, 堂本貴寛, 源利成, 太田哲生
- Organizer
  第26回日本がん転移学会学術集会
- Data Source
  KAKENHI-PROJECT-17K15022
[Presentation] Aberrant glycogen synthase kinase (GSK)3β participates in tumor-promoting autophagy in colorectal cancer.2017
- Author(s)
  Takahiro Domoto, Ilya V. Pyko, Masahiro Uehara, Dilireba Bolidong, Toshinari Minamoto.
- Organizer
  The 9th International Conference on the International Society of Gastroenterological Carcinogenesis
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04928
[Presentation] 膵がんのゲムシタビン耐性獲得におけるglycogen synthase kinase (GSK)-3βの役割2017
- Author(s)
  上原将大, 堂本貴寛, 竹中哲, ピコイリア, 島崎猛夫, 宮下知治, 太田哲生, 源利成
- Organizer
  第28回日本消化器癌発生学会・第9回国際消化器癌発生会議
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K15022
[Presentation] 膵がんのゲムシタビン耐性獲得におけるglycogen synthase kinase (GSK)-3βの役割り．2017
- Author(s)
  上原将大，堂本貴寛，竹中哲，ピコイリア，島崎猛夫，宮下知治，太田哲生，源利成．
- Organizer
  第76回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-15H04928
[Presentation] Therapeutic effect of glycogen synthase kinase-3β inhibition against osteosarcoma via activation of β-catenin.2017
- Author(s)
  Shingo Shimozaki, Norio Yamamoto, Takahiro Domoto, Toshinari Minamoto, Robert M. Hoffman, Hiroyuki Tsuchiya.
- Organizer
  The 19th International Society of Limb Salvage General Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04928
[Presentation] Putative role of glycogen synthase kinase (GSK)-3β in acquired resistance to gemcitabine (GEM) in pancreatic cancer2017
- Author(s)
  Masahiro Uehara, Takahiro Domoto, Satoshi Takenaka, Ilya V. Pyko, Takeo Shimasaki, Tomoharu Miyashita, Tetsuo Ohta, Toshinari Minamoto
- Organizer
  第76回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-17K15022
[Presentation] GSK3β阻害による軟部肉腫の新しい分子標的治療2017
- Author(s)
  阿部健作，山本憲男，堂本貴寛，林克洋，武内章彦，樋口貴史，谷口裕太，相羽久輝，源利成，土屋弘行
- Organizer
  第32回日本整形外科学会基礎学術集会
- Data Source
  KAKENHI-PROJECT-17K15022
[Presentation] Sensitizing patient-derived glioblastoma stem-like cells to temozolomide by glycogen synthase kinase 3beta inhibition2017
- Author(s)
  Ilya V. Pyko, Takahiro Domoto, Mitsutoshi Nakada, Toshinari Minamoto
- Organizer
  第76回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-17K15022
[Presentation] Aberrant glycogen synthase kinase (GSK) 3β participates in tumor-promoting autophagy in colorectal cancer2017
- Author(s)
  Takahiro Domoto, Ilya V. Pyko, Masahiro Uehara, Dilireba Bolidong, Toshinari Minamoto
- Organizer
  第28回日本消化器癌発生学会・第9回国際消化器癌発生会議
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K15022
[Presentation] Influence of anti-cancer drug against exosome dynamics in pancreatic cancer cells2017
- Author(s)
  Takeo Shimasaki, Satoko Yamamoto, Takahiro Domoto, Toshinari Minamoto.
- Organizer
  第28回日本消化器癌発生学会・第9回国際消化器癌発生会議
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K15022
[Presentation] ゲムシタビン獲得耐性膵がん細胞の幹細胞性と浸潤能におけるGSK3βの作用2017
- Author(s)
  堂本貴寛, 竹中哲, 宮下知治, 上原将大, 太田哲生, 源利成
- Organizer
  第26回日本がん転移学会学術集会
- Data Source
  KAKENHI-PROJECT-17K15022
[Presentation] ゲムシタビン獲得耐性膵がん細胞の幹細胞性と浸潤能におけるGSK3βの作用．2017
- Author(s)
  堂本貴寛，竹中哲，宮下知治，上原将大，太田哲生，源利成．
- Organizer
  第26回日本がん転移学会学術集会・総会
- Data Source
  KAKENHI-PROJECT-15H04928
[Presentation] Aberrant glycogen synthase kinase (GSK)3β participates in proliferation of esophageal squamous cell carcinoma (ESCC)2017
- Author(s)
  Dilireba Bolidong, Takahiro Domoto, Tomoyuki Okumura, Yoshio Endo, Masahiro Uehara, Ilya V. Pyko, Tomoharu Miyashita, Toshinari Minamoto
- Organizer
  第76回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-17K15022
[Presentation] GSK3βはゲムシタビン獲得耐性膵がんの浸潤を促進する．2017
- Author(s)
  堂本貴寛，宮下知治，竹中哲，上原将大，太田哲生，源利成．
- Organizer
  第76回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-15H04928
[Presentation] Glycogen synthase kinase (GSK)3βの食道扁平上皮がん促進作用の検討．2017
- Author(s)
  ボリドンディリレバ，堂本貴寛，奥村知之，遠藤良夫，上原将大，ピコイリア，宮下知治，源利成．
- Organizer
  第76回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-15H04928
[Presentation] Novel molecular therapy targeting aberrant GSK3beta in soft tissue sarcomas2017
- Author(s)
  阿部健作，山本憲男，堂本貴寛，林克洋，武内章彦，樋口貴史，谷口裕太，相羽久輝，源利成，土屋弘行
- Organizer
  第55回日本癌治療学会学術集会
- Data Source
  KAKENHI-PROJECT-17K15022
[Presentation] Putative role of glycogen synthase kinase (GSK)-3β in acquired resistance to gemcitabine (GEM) in pancreatic cancer.2017
- Author(s)
  Masahiro Uehara, Takahiro Domoto, Satoshi Takenaka, Ilya Pyko, Takeo Shimasaki, Tomoharu Miyashita, Tetsuo Ohta, Toshinari Minamoto.
- Organizer
  The 9th International Conference on the International Society of Gastroenterological Carcinogenesis
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04928
[Presentation] 大腸がんにおけるCRD-BPの発現とがんの臨床病理学的特性や分子病態との関連解析2017
- Author(s)
  富田泰斗，藤井頼孝，三浦聖子，藤田純，甲斐田大資，大西敏雄，藤田秀人，木南伸一，中野泰治，上田順彦，堂本貴寛，源利成，小坂健夫
- Organizer
  第72回日本消化器外科学会総会
- Data Source
  KAKENHI-PROJECT-17K15022
[Presentation] 膵がん治療耐性に伴う幹細胞性とGSK3β/STAT3経路の機能解析．2017
- Author(s)
  竹中哲，宮下知治，上原将大，堂本貴寛，源　利成，太田哲生．
- Organizer
  第26回日本がん転移学会学術集会・総会
- Data Source
  KAKENHI-PROJECT-15H04928
[Presentation] Glycogen synthase kinase (GSK)3β facilitates invasive capacity in pancreatic cancer with acquired gemcitabine resistance2017
- Author(s)
  Takahiro Domoto, Tomoharu Miyashita, Satoshi Takenaka, Masahiro Uehara, Tetsuo Ohta, Toshinari Minamoto
- Organizer
  第76回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-17K15022
[Presentation] 膵癌細胞のエクソソーム動態の解析2017
- Author(s)
  島崎猛夫，山本聡子，堂本貴寛，源利成
- Organizer
  第48回日本膵臓学会大会
- Data Source
  KAKENHI-PROJECT-17K15022
[Presentation] GSK3βはがん促進性オートファジーを介して大腸がん細胞の生存に関与する．2016
- Author(s)
  堂本貴寛，ほか，源利成
- Organizer
  第75回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜，横浜
- Year and Date
  2016-10-06
- Data Source
  KAKENHI-PROJECT-15K15493
[Presentation] GSK3βはがん促進性オートファジーを介して大腸がん細胞の生存に関与する．2016
- Author(s)
  堂本貴寛，ほか，源利成
- Organizer
  第75回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜，横浜
- Year and Date
  2016-10-06
- Data Source
  KAKENHI-PROJECT-15H04928
[Presentation] 大腸がん糖代謝特性におけるGSK3βの役割2015
- Author(s)
  堂本貴寛，ほか，源利成
- Organizer
  第3回がんと代謝研究会
- Place of Presentation
  石川県立音楽堂，金沢
- Year and Date
  2015-07-16
- Data Source
  KAKENHI-PROJECT-15K15493
[Presentation] GSK3βはFAK-Rac1-JNK経路を介して膠芽腫細胞の浸潤を推進する2015
- Author(s)
  堂本貴寛, 滝野隆久, 佐藤博, 源利成
- Organizer
  第24回日本がん転移学会学術集会・総会
- Place of Presentation
  大阪市・シティプラザ大阪
- Year and Date
  2015-07-23
- Data Source
  KAKENHI-PROJECT-25860233
[Presentation] GSK3βはFAK/Rac1/ JNK経路を介するMMPsの発現亢進によって膠芽腫細胞の浸潤を推進する2015
- Author(s)
  堂本貴寛，ほか，源利成
- Organizer
  第74回日本癌学会学術総会
- Place of Presentation
  名古屋国際会議場，名古屋
- Year and Date
  2015-10-08
- Data Source
  KAKENHI-PROJECT-15H04928
[Presentation] 大腸がん糖代謝特性におけるGSK3βの役割2015
- Author(s)
  堂本貴寛，ほか，源利成
- Organizer
  第3回がんと代謝研究会
- Place of Presentation
  石川県立音楽堂，金沢
- Year and Date
  2015-07-16
- Data Source
  KAKENHI-PROJECT-15H04928
[Presentation] Vinculin negatively regulates transcription of MT1-MMP through MEK/ERK pathway2015
- Author(s)
  Taisuke Yoshimoto, Takahisa Takino, Takahiro Domoto, Syuichi Kawashiri, Hiroshi Sato
- Organizer
  第74回日本癌学会学術総会
- Place of Presentation
  名古屋市・名古屋国際会議場
- Year and Date
  2015-10-08
- Data Source
  KAKENHI-PROJECT-25860233
[Presentation] GSK3βはFAK-Rac1-JNK経路を介して膠芽腫細胞の浸潤を推進する2015
- Author(s)
  堂本貴寛，ほか，源利成
- Organizer
  第24回日本がん転移学会学術集会・総会
- Place of Presentation
  シティプラザ大阪，大阪
- Year and Date
  2015-07-23
- Data Source
  KAKENHI-PROJECT-15H04928
[Presentation] 大腸がん糖代謝特性におけるGSK3βの役割2015
- Author(s)
  堂本貴寛, 紙健次郎, 廣瀬まゆみ, Ilya V. Pyko, 土原一哉, 曽我朋義, 江角浩安, 源利成
- Organizer
  第3回がんと代謝研究会
- Place of Presentation
  金沢市・県立音楽堂
- Year and Date
  2015-07-16
- Data Source
  KAKENHI-PROJECT-25860233
[Presentation] Identification and analysis of EMT-inducible factor by gemcitabine in pancreatic cancer cells2015
- Author(s)
  Takeo Shimasaki, Satoko Yamamoto, Takahiro Domoto, Tomiyasu Arisawa, Naohisa Tomosugi, Toshinari Minamoto
- Organizer
  第74回日本癌学会学術総会
- Place of Presentation
  名古屋市・名古屋国際会議場
- Year and Date
  2015-10-08
- Data Source
  KAKENHI-PROJECT-25860233
[Presentation] VinculinはMEK/ERK経路を介したMT1-MMPの転写を負に制御する2015
- Author(s)
  吉本泰祐, 滝野隆久, 堂本貴寛, 川尻秀一, 佐藤博
- Organizer
  第24回日本がん転移学会学術集会・総会
- Place of Presentation
  大阪市・シティプラザ大阪
- Year and Date
  2015-07-23
- Data Source
  KAKENHI-PROJECT-25860233
[Presentation] Tip60 regulates MT1-MMP transcription and invasion of glioblastoma cells through NF-kappaB pathway2015
- Author(s)
  Takahisa Takino, Mitsutoshi Nakada, Takahiro Domoto, Hiroshi Sato
- Organizer
  第74回日本癌学会学術総会
- Place of Presentation
  名古屋市・名古屋国際会議場
- Year and Date
  2015-10-08
- Data Source
  KAKENHI-PROJECT-25860233
[Presentation] GSK3βはFAK/Rac1/ JNK経路を介するMMPsの発現亢進によって膠芽腫細胞の浸潤を推進する2015
- Author(s)
  堂本貴寛，ほか，源利成
- Organizer
  第74回日本癌学会学術総会
- Place of Presentation
  名古屋国際会議場，名古屋
- Year and Date
  2015-10-08
- Data Source
  KAKENHI-PROJECT-15K15493
[Presentation] GSK3β阻害によるβ-カテニン活性化の骨肉腫治療効果2015
- Author(s)
  下﨑真吾, 山本憲男, 林克洋, 木村浩明, 武内章彦, 三輪真嗣, 稲谷弘幸, 青木裕, 樋口貴史, 阿部健作, 堂本貴寛, 大塚隆信, 源利成, 土屋弘行
- Organizer
  第53回日本癌治療学会学術集会
- Place of Presentation
  京都市・国立京都国際会館
- Year and Date
  2015-10-29
- Data Source
  KAKENHI-PROJECT-25860233
[Presentation] GSK3β sustains invasion of glioblastoma by expression of MMPs via the FAK, Rac1 and JNK-mediated pathway2015
- Author(s)
  Takahiro Domoto, Takuya Furuta, Takahisa Takino, Hiroshi Sato, Mitsutoshi Nakada, Toshinari Minamoto
- Organizer
  第74回日本癌学会学術総会
- Place of Presentation
  名古屋市・名古屋国際会議場
- Year and Date
  2015-10-08
- Data Source
  KAKENHI-PROJECT-25860233
[Presentation] Inhibition of GSK3β rectifies aberrant glucose metabolism in colon cancer cells2014
- Author(s)
  堂本貴寛
- Organizer
  金沢国際がん生物学＆アカデミア創薬シンポジウム
- Place of Presentation
  金沢市
- Data Source
  KAKENHI-PROJECT-25860233
[Presentation] 大腸がんの糖代謝経路におけるGSK3βの機能解析2013
- Author(s)
  堂本貴寛
- Organizer
  第24回日本消化器癌発生学会学術総会
- Place of Presentation
  金沢市
- Data Source
  KAKENHI-PROJECT-25860233
[Presentation] Putative pathological role of GSK3βin aberrant glucose metabolism in colon cancer cells2013
- Author(s)
  堂本貴寛
- Organizer
  第72回日本癌学会学術総会
- Place of Presentation
  横浜市
- Data Source
  KAKENHI-PROJECT-25860233
[Presentation] Involvement of GSK3β in aberrant glucose metabolism in colon cancer
- Author(s)
  堂本貴寛, 紙健次郎, 廣瀬まゆみ, Ilia V. Pyko, 曽我朋義, 江角浩安, 源利成
- Organizer
  第73回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜（神奈川県・横浜市）
- Year and Date
  2014-09-25 – 2014-09-27
- Data Source
  KAKENHI-PROJECT-25860233
[Presentation] 大腸がんにおけるGSK3β制御性miRNAの発現と病態との関連
- Author(s)
  佐々木規雄, 堂本貴寛, 米村圭祐, 森脇美優, Ilia V. Pyko, 中村慶史, 太田哲夫, 河原栄, 源利成
- Organizer
  日本癌学会主催金沢大学がん進展制御研究所共催日本癌学会シンポジウム共同利用・共同研究拠点シンポジウム
- Place of Presentation
  石川県立音楽堂（石川県・金沢市）
- Year and Date
  2015-01-22 – 2015-01-23
- Data Source
  KAKENHI-PROJECT-25860233
[Presentation] Repurposing of the GSK3β-inhibiting drugs for treatment of gastrointestinal cancer
- Author(s)
  廣瀬まゆみ, 堂本貴寛, 源利成
- Organizer
  第73回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜（神奈川県・横浜市）
- Year and Date
  2014-09-25 – 2014-09-27
- Data Source
  KAKENHI-PROJECT-25860233
[Presentation] Glycogen synthase kinase 3β sustains invasion of glioblastoma via the focal adhesion kinase, Rac1 and JNK-mediated pathway
- Author(s)
  Takahiro Domoto, Yuri Chikano, Takuya Furuta, Hemragul Sabit, Ilya V. Pyko, Takahisa Takino, Yutaka Hayashi, Hiroshi Sato, Mitsutoshi Nakada, Toshinari Minamoto
- Organizer
  日本癌学会主催金沢大学がん進展制御研究所共催日本癌学会シンポジウム共同利用・共同研究拠点シンポジウム
- Place of Presentation
  石川県立音楽堂（石川県・金沢市）
- Year and Date
  2015-01-22 – 2015-01-23
- Data Source
  KAKENHI-PROJECT-25860233

1. MINAMOTO TOSHINARI (50239323)

# of Collaborated Projects: 4 results

# of Collaborated Products: 46 results
2. OHTA Tetsuo (40194170)

# of Collaborated Projects: 2 results

# of Collaborated Products: 6 results
3. MIYASHITA Tomoharu (30397210)

# of Collaborated Projects: 2 results

# of Collaborated Products: 7 results
4. WONG Richard (30464035)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. ISHIGAKI Yasuhito (20232275)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. SOGA Tomoyoshi (60338217)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. SEIO Kohshi (20313356)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 佐藤博

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
9. 小林亜紀子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 山本靖彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 武内章彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

DOUMOTO Takahiro 堂本 貴寛

Domoto Takahiro 堂本 貴寛

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治療耐性膵がんの悪性進展ネットワークの解明と治療法開発への応用Principal Investigator

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抗がん剤耐性獲得膵がん細胞における悪性形質連関の解明と治療法開発Principal Investigator

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Exploring the characteristics of tumor-promoting glycometabolism enhanced by GSK3beta toward application to cancer therapy.Principal Investigator

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Exploring biological basis of aberrant cancer energy metabolism induced by GSK3beta toward application to cancer treatmentPrincipal Investigator

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Identification and functional analysis of nuclear pore complex components that function to transport beta-catenin between cytoplasm and nucleus

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Investigation of biological basis of GSK3beta-targeted therapy and its translation to colorectal cancer treatment

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Exploring biological basis of aberrant energy metabolic property of gastrointestinal cancer toward application to cancer treatmentPrincipal Investigator

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[Book] 肝胆膵 「膵がんの増殖，浸潤と治療不応性を繋ぐ治療標的GSK3β」2017

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[Journal Article] Glycogen synthase kinase 3β: the nexus of chemoresistance, invasive capacity, and cancer stemness in pancreatic cancer2024

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[Journal Article] Deactivation of GSK3β by heat shock inducible tumor small protein (HITS, FAM107B) attenuates hyperthermia-induced pro-migratory activity in colorectal cancer cells2023

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[Journal Article] Discovery of a Novel Aminocyclopropenone Compound That Inhibits BRD4-Driven Nucleoporin NUP210 Expression and Attenuates Colorectal Cancer Growth2022

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[Journal Article] Potential therapeutic effect of targeting glycogen synthase kinase 3β in esophageal squamous cell carcinoma2020

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[Journal Article] Glycogen synthase kinase 3β in cancer biology and treatment.2020

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[Journal Article] Glycogen synthase kinase-3β participates in acquired resistance to gemcitabine in pancreatic cancer2020

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DOUMOTO Takahiro 堂本貴寛

Domoto Takahiro 堂本貴寛

[Book] 肝胆膵「膵がんの増殖，浸潤と治療不応性を繋ぐ治療標的GSK3β」2017

[Journal Article] Colorectal cancer cells require glycogen synthase kinase-3β for sustaining mitosis via translocated promoter region (TPR)-dynein interaction2018