Shibata Tomonori 柴田知範

Researcher Number	80711960
Other IDs
Affiliation (Current)	2025: 大阪大学, 産業科学研究所, 招へい教員
Affiliation (based on the past Project Information) *help	2022 – 2023: 大阪大学, 産業科学研究所, 招へい教員 2017 – 2023: 大阪大学, 産業科学研究所, 助教 2016: 大阪大学, 産業科学研究所, 特任助教(常勤) 2015: 大阪大学, 産業科学研究所, 特任助教 2014: 京都大学, iPS細胞研究所, 研究員
Review Section/Research Field	Principal Investigator Medium-sized Section 37:Biomolecular chemistry and related fields / Basic Section 37030:Chemical biology-related / Chemical biology / Bio-related chemistry Except Principal Investigator Medium-sized Section 37:Biomolecular chemistry and related fields
Keywords	Principal Investigator リピートRNA / 脊髄小脳変性症 / RNA結合性低分子 / UGGAAリピート / 脊髄小脳変性症31型 / RNA / 組織透明化 / CAGリピート結合分子 / 全脳イメージング / ハンチントン病 … More / CAGリピート / 経鼻投与 / RNA標的低分子 / 核酸結合性分子 / ケミカルバイオロジー / マイクロサテライトリピート病 / RNA結合性分子 / ペンタヌクレオチドリピート / RNA結合タンパク質 / 脊髄小脳失調症31型 / リピート病 / ナノマシン / 分子ロボット / RNAナノ構造 / 核酸ナノ構造 / RNA-タンパク質複合体 / RNAナノテクノロジー / 核酸ナノテクノロジー / タンパク質 … More Except Principal Investigator 化学修飾 / シトシン / 異常伸長 / DNA / 短縮機構解明 / 経路探索 / 結合分子 / ミスマッチ / スリップアウト構造 / 低分子 / 修復酵素 / リピート Less

Elucidation of the binding pathway of mismatch-binding molecules to abnormally elongated repeat sequences and their shortening-inducing effects
- Principal Investigator
  
  中谷和彦
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 37:Biomolecular chemistry and related fields
- Research Institution
  Osaka University
Elucidation of intracerebral distribution of CAG repeat binding molecules after intranasal administration and verification of effect on repeat contraction.Principal Investigator
- Principal Investigator
  
  Shibata Tomonori
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 37:Biomolecular chemistry and related fields
- Research Institution
  Osaka University
脊髄小脳変性症31型を標的とする低分子の作用機序解明と毒性リピートRNA機能抑制Principal Investigator
- Principal Investigator
  
  柴田知範
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 37030:Chemical biology-related
- Research Institution
  Osaka University
Elucidation of action mechanism of repeat RNA-binding small molecules that improve disease phenotype in spinocerebellar ataxia type 31Principal Investigator
- Principal Investigator
  
  Shibata Tomonori
- Project Period (FY)
  2017 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Chemical biology
- Research Institution
  Osaka University
Functional molecular robot using RNA/RNP nanostructuresPrincipal Investigator
- Principal Investigator
  
  Shibata Tomonori
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Bio-related chemistry
- Research Institution
  Osaka University
  Kyoto University

All 2023 2022 2021 2019 2018 2015 Other

All Journal Article Presentation Book Patent

[Book] Methods in Molecular Biology 1316 (Chapter 14)2015
- Author(s)
  Tomonori Shibata, Yuki Suzuki, Hiroshi Sugiyama, Masayuki Endo, and Hirohide Saito
- Publisher
  Human press
- Data Source
  KAKENHI-PROJECT-26810089
[Book] Methods Mol Biol.2015
- Author(s)
  Shibata T, Suzuki Y, Sugiyama H, Endo M, Saito H
- Publisher
  Humana Press
- Data Source
  KAKENHI-PROJECT-26810089
[Journal Article] A small molecule binding to TGGAA pentanucleotide repeats that cause spinocerebellar ataxia type 312023
- Author(s)
  Shibata Tomonori、Nakatani Kazuhiko
- Journal Title
  
  Bioorganic & Medicinal Chemistry Letters
  
  Volume: 79 Pages: 129082-129082
- DOI
  10.1016/j.bmcl.2022.129082
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K19049, KAKENHI-PROJECT-19H00924, KAKENHI-PROJECT-20H02880, KAKENHI-PROJECT-22H00351
[Journal Article] Fluorescent indicator displacement assay for the discovery of UGGAA repeat-targeted small molecules2023
- Author(s)
  Shibata Tomonori、Matsumoto Yasumasa、Iihara Akiko、Yamada Kazunori、Ochiai Hiroshi、Saito Ryo、Kusaka Shinichi、Kume Toshiyuki
- Journal Title
  
  Chemical Communications
  
  Volume: 59 Issue: 34 Pages: 5071-5074
- DOI
  10.1039/d3cc00837a
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20H02880
[Journal Article] Intracerebral Distribution of CAG Repeat-Binding Small Molecule Visualized by Whole-Brain Imaging2023
- Author(s)
  Murakami Eitaro、Nakamori Masayuki、Nakatani Kazuhiko、Shibata Tomonori、Tainaka Kazuki
- Journal Title
  
  Bioconjugate Chemistry
  
  Volume: 34 Issue: 12 Pages: 2187-2193
- DOI
  10.1021/acs.bioconjchem.3c00470
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K22597, KAKENHI-PROJECT-21K19049, KAKENHI-PROJECT-22H00351, KAKENHI-PROJECT-23K24198
[Journal Article] Small molecule targeting r(UGGAA)n disrupts RNA foci and alleviates disease phenotype in Drosophila model2021
- Author(s)
  Shibata Tomonori、Nagano Konami、Ueyama Morio、Ninomiya Kensuke、Hirose Tetsuro、Nagai Yoshitaka、Ishikawa Kinya、Kawai Gota、Nakatani Kazuhiko
- Journal Title
  
  Nature Communications
  
  Volume: 12 Issue: 1 Pages: 1-13
- DOI
  10.1038/s41467-020-20487-4
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K06478, KAKENHI-PROJECT-19K22254, KAKENHI-PROJECT-19H00924, KAKENHI-PROJECT-17K01962, KAKENHI-PLANNED-20H05927, KAKENHI-PROJECT-20H00448, KAKENHI-PROJECT-20H02880
[Journal Article] Short Tandem Repeat Contractions during In Vitro DNA Synthesis by Repeat-binding Molecules2021
- Author(s)
  Hagihara Masaki、Dohno Chikara、Saito Kaoru、Sugimoto Kazuhiro、Hishinuma Yuta、Sohma Yuri、Shibata Tomonori、Nakatani Kazuhiko
- Journal Title
  
  Chemistry Letters
  
  Volume: 50 Issue: 11 Pages: 1848-1851
- DOI
  10.1246/cl.210415
- NAID
  130008113718
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H00924, KAKENHI-PROJECT-18H02107, KAKENHI-PROJECT-20H02880
[Patent] 脊髄小脳変性症31型抑制剤2018
- Inventor(s)
  中谷和彦、柴田知範、永井義隆、上山盛夫
- Industrial Property Rights Holder
  中谷和彦、柴田知範、永井義隆、上山盛夫
- Industrial Property Rights Type
  実用新案
- Filing Date
  2018
- Acquisition Date
  2018
- Data Source
  KAKENHI-PROJECT-17K01962
[Presentation] RNA反復配列を標的とした光応答性リガンドによる細胞内RNA fociの形成制御2023
- Author(s)
  藤原侑亮、柴田知範、堂野主税、中谷和彦
- Organizer
  日本化学会第103春季年会
- Data Source
  KAKENHI-PROJECT-21K19049
[Presentation] RNA反復配列を標的とした光応答性リガンドによる細胞内RNA fociの形成制御2023
- Author(s)
  藤原侑亮、柴田知範、堂野主税、中谷和彦
- Organizer
  日本化学会第103春季年会
- Data Source
  KAKENHI-PROJECT-20H02880
[Presentation] Evaluation of APOBEC-catalyzed cytosine deamination for the repeat DNAs2022
- Author(s)
  Luyan Zhang, Tomonori Shibata, Asako Murata, Kazuhiko Nakatani
- Organizer
  The 49th International Symposium on Nucleic Acids Chemistry
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K19049
[Presentation] Control of RNA Foci Formation by Photo-Switchable Ligands2022
- Author(s)
  Yusuke Fujiwara, Tomonori Shibata, Chikara Dohno, Kazuhiko Nakatani
- Organizer
  The 49th International Symposium on Nucleic Acids Chemistry(国際学会)
- Data Source
  KAKENHI-PROJECT-20H02880
[Presentation] 全脳イメージングを用いたCAGリピート結合分子の脳内分布解析2022
- Author(s)
  村上英太郎、柴田知範、中森雅之、田井中一貴、中谷和彦
- Organizer
  RNAフロンティアミーティング
- Data Source
  KAKENHI-PROJECT-20H02880
[Presentation] Control of RNA Foci Formation by Photo-Switchable Ligands2022
- Author(s)
  Yusuke Fujiwara, Tomonori Shibata, Chikara Dohno, Kazuhiko Nakatani
- Organizer
  The 49th International Symposium on Nucleic Acids Chemistry
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K19049
[Presentation] Alleviation of RNA toxicity by a small molecule targeting UGGAA repeat in spinocerebellar ataxia type 312022
- Author(s)
  Tomonori Shibata, Konami Nagano, Morio Ueyama, Kensuke Ninomiya, Tetsuro Hirose, Yoshitaka Nagai, Kinya Ishikawa, Gota Kawai, Kazuhiko Nakatani
- Organizer
  NEURO2022
- Invited
- Data Source
  KAKENHI-PROJECT-21K19049
[Presentation] Alleviation of RNA toxicity by a small molecule targeting UGGAA repeat in spinocerebellar ataxia type 312022
- Author(s)
  Tomonori Shibata, Konami Nagano, Morio Ueyama, Kensuke Ninomiya, Tetsuro Hirose, Yoshitaka Nagai, Kinya Ishikawa, Gota Kawai, Kazuhiko Nakatani
- Organizer
  NEURO2022
- Invited
- Data Source
  KAKENHI-PROJECT-20H02880
[Presentation] 全脳イメージングを用いたCAGリピート結合分子の脳内分布解析2022
- Author(s)
  村上英太郎、柴田知範、中森雅之、田井中一貴、中谷和彦
- Organizer
  RNAフロンティアミーティング
- Data Source
  KAKENHI-PROJECT-21K19049
[Presentation] Evaluation of APOBEC-catalyzed cytosine deamination for the repeat DNAs2022
- Author(s)
  Luyan Zhang, Tomonori Shibata, Asako Murata, Kazuhiko Nakatani
- Organizer
  The 49th International Symposium on Nucleic Acids Chemistry(国際学会)
- Data Source
  KAKENHI-PROJECT-20H02880
[Presentation] Small molecule targeting r(UGGAA)n in spinocerebellar ataxia type 312021
- Author(s)
  ○Tomonori Shibata, Konami Nagano, Morio Ueyama, Kensuke Ninomiya, Tetsuro Hirose, Yoshitaka Nagai, Kinya Ishikawa, Gota Kawai, Kazuhiko Nakatani
- Organizer
  Pacifichem 2021
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H02880
[Presentation] 全脳イメージングを用いたCAGリピート結合分子の薬物動態解析2021
- Author(s)
  ○村上英太郎、柴田知範、中森雅之、田井中一貴、中谷和彦
- Organizer
  日本ケミカルバイオロジー学会第15回年会
- Data Source
  KAKENHI-PROJECT-21K19049
[Presentation] Small molecule targeting UGGAA pentanucleotide repeat alleviates disease phenotype in spinocerebellar ataxia type 312021
- Author(s)
  ○Tomonori Shibata, Konami Nagano, Morio Ueyama, Kensuke Ninomiya, Tetsuro Hirose, Yoshitaka Nagai, Kinya Ishikawa, Gota Kawai, Kazuhiko Nakatani
- Organizer
  ISNAC2021
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H02880
[Presentation] A small molecule targeting UGGAA pentanucleotide repeats that cause spinocerebellar ataxia type 312021
- Author(s)
  ○Tomonori Shibata, Konami Nagano, Morio Ueyama, Kensuke Ninomiya, Tetsuro Hirose, Yoshitaka Nagai, Kinya Ishikawa, Gota Kawai, Kazuhiko Nakatani
- Organizer
  The 44th Annual Meeting of the Molecular Biology Society of Japan (MBSJ2021)
- Invited
- Data Source
  KAKENHI-PROJECT-20H02880
[Presentation] RNA binding small molecule that mitigates disease phenotype in spinocerebellar ataxia type 312019
- Author(s)
  Tomonori Shibata, Konami Nagano, Morio Ueyama, Yoshitaka Nagai, Kinya Ishikawa, Gota Kawai, Kazuhiko Nakatani
- Organizer
  The Commemorative International Symposium of the Japan Society of Nucleic Acids Chemistry (CISNAC 2019)
- Data Source
  KAKENHI-PROJECT-17K01962
[Presentation] 脊髄小脳変性症 31 型を標的とする RNA 結合性低分子2019
- Author(s)
  柴田知範、長野来南、上山盛夫、永井義隆、石川欽也、河合剛太、中谷和彦
- Organizer
  日本ケミカルバイオロジー学会第14回年会
- Data Source
  KAKENHI-PROJECT-17K01962
[Presentation] A small molecule that alleviates RNA-mediated neurodegeneration in spinocerebellar ataxia type 312018
- Author(s)
  Tomonori Shibata
- Organizer
  Aptamer in Boulder
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K01962
[Presentation] Synthetic RNA-protein nano machines that function in vitro and in live cell2015
- Author(s)
  ○Shibata T, Suzuki Y, Sugiyama H, Endo M, Saito H
- Organizer
  ISNAC20
- Place of Presentation
  イーグレ姫路 (兵庫県　姫路市)
- Year and Date
  2015-09-23
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26810089
[Presentation] タンパク質応答性RNAナノマシン2015
- Author(s)
  ○柴田知範、鈴木勇輝、杉山弘、遠藤政幸、齊藤博英
- Organizer
  日本RNA学会年会
- Place of Presentation
  ホテルライフォート札幌 (北海道　札幌市)
- Year and Date
  2015-07-15
- Data Source
  KAKENHI-PROJECT-26810089
[Presentation] A RNA-protein-based nanomachine for controlling functional RNAs
- Author(s)
  Tomonori Shibata, Yuki Suzuki, Hiroshi Sugiyama, Masayuki Endo, Hirohide Saito
- Organizer
  The 41st International Symposium on Nucleic Acids Chemistry 2014
- Place of Presentation
  北九州
- Year and Date
  2014-11-05 – 2014-11-07
- Data Source
  KAKENHI-PROJECT-26810089
[Presentation] Photo-regulation of RNA-protein-based nanostructures
- Author(s)
  Tomonori Shibata, Kenzo Fujimoto, Yuki Suzuki, Hiroshi Sugiyama, Masayuki Endo, Masahiro Takinoue, Hirohide Saito
- Organizer
  20th International Conference on DNA computing and Molecular Programming
- Place of Presentation
  京都
- Year and Date
  2014-09-22 – 2014-09-26
- Data Source
  KAKENHI-PROJECT-26810089

1. 中谷和彦 (70237303)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
2. 山田剛史 (80633263)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 二宮賢介

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. 中森雅之

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Shibata Tomonori 柴田 知範

Research Projects

Research Products

Co-Researchers

Elucidation of the binding pathway of mismatch-binding molecules to abnormally elongated repeat sequences and their shortening-inducing effects

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of intracerebral distribution of CAG repeat binding molecules after intranasal administration and verification of effect on repeat contraction.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

脊髄小脳変性症31型を標的とする低分子の作用機序解明と毒性リピートRNA機能抑制Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of action mechanism of repeat RNA-binding small molecules that improve disease phenotype in spinocerebellar ataxia type 31Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Functional molecular robot using RNA/RNP nanostructuresPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] Methods in Molecular Biology 1316 (Chapter 14)2015

Author(s)

Publisher

Data Source

[Book] Methods Mol Biol.2015

Author(s)

Publisher

Data Source

[Journal Article] A small molecule binding to TGGAA pentanucleotide repeats that cause spinocerebellar ataxia type 312023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Fluorescent indicator displacement assay for the discovery of UGGAA repeat-targeted small molecules2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Intracerebral Distribution of CAG Repeat-Binding Small Molecule Visualized by Whole-Brain Imaging2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Small molecule targeting r(UGGAA)n disrupts RNA foci and alleviates disease phenotype in Drosophila model2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Short Tandem Repeat Contractions during In Vitro DNA Synthesis by Repeat-binding Molecules2021

Author(s)

Journal Title

DOI

NAID

Data Source

[Patent] 脊髄小脳変性症31型抑制剤2018

Inventor(s)

Industrial Property Rights Holder

Industrial Property Rights Type

Filing Date

Acquisition Date

Data Source

[Presentation] RNA反復配列を標的とした光応答性リガンドによる細胞内RNA fociの形成制御2023

Author(s)

Organizer

Data Source

[Presentation] RNA反復配列を標的とした光応答性リガンドによる細胞内RNA fociの形成制御2023

Shibata Tomonori 柴田知範