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Yamada Takeshi  山田 剛史

Researcher Number 80633263
Other IDs
  • ORCIDhttps://orcid.org/0000-0003-3275-415X
Affiliation (Current) 2023: 東京医科歯科大学, 統合研究機構, 特任講師
Affiliation (based on the past Project Information) *help 2019 – 2022: 大阪大学, 産業科学研究所, 助教
2016 – 2018: 大阪大学, 産業科学研究所, 特任助教(常勤)
2015: 大阪大学, 産業科学研究所, 特任助教
Review Section/Research Field
Principal Investigator
Basic Section 37010:Bio-related chemistry / Bio-related chemistry
Except Principal Investigator
Medium-sized Section 37:Biomolecular chemistry and related fields
Keywords
Principal Investigator
核酸 / RNA / 有機合成 / ケミカルバイオロジー / 低分子 / トリヌクレオチドリピート / ミスマッチ塩基対 / DNA / トリプレットリピート / スプライシング … More / アンチセンスオリゴ / 環状RNA / 分子認識 / オリゴマー / 有機合成化学 / 生体関連化学 / イミダゾール / チオール / ミスマッチ / トリンクレオチドリピート … More
Except Principal Investigator
短縮機構解明 / 経路探索 / 結合分子 / ミスマッチ / リピート Less
  • Research Projects

    (5 results)
  • Research Products

    (50 results)
  • Co-Researchers

    (2 People)
  •  Elucidation of the binding pathway of mismatch-binding molecules to abnormally elongated repeat sequences and their shortening-inducing effects

    • Principal Investigator
      中谷 和彦
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Review Section
      Medium-sized Section 37:Biomolecular chemistry and related fields
    • Research Institution
      Osaka University
  •  Development of ASOs which up-regulate back-splicing producing circular RNAsPrincipal Investigator

    • Principal Investigator
      山田 剛史
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 37010:Bio-related chemistry
    • Research Institution
      Osaka University
  •  Development of small molecules that spontaneously oligomerize on trinucleotide repeatsPrincipal Investigator

    • Principal Investigator
      YAMADA Takeshi
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 37010:Bio-related chemistry
    • Research Institution
      Osaka University
  •  Synthetic study of functional mismatch binding molecules for selective hydrolysis of expanded repeat RNAsPrincipal Investigator

    • Principal Investigator
      YAMADA Takeshi
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Bio-related chemistry
    • Research Institution
      Osaka University
  •  Development of small molecule ligands to inhibit expansion of CAG trinulceotide repeatPrincipal Investigator

    • Principal Investigator
      Yamada Takeshi
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Bio-related chemistry
    • Research Institution
      Osaka University

All 2022 2021 2020 2019 2018 2017 2016 2015

All Journal Article Presentation

  • [Journal Article] Mismatch binding ligand upregulated back-splicing reaction producing circular RNA in a cellular model2022

    • Author(s)
      Ni Lu、Yamada Takeshi、Murata Asako、Nakatani Kazuhiko
    • Journal Title

      Chemical Communications

      Volume: 58 Issue: 22 Pages: 3629-3632

    • DOI

      10.1039/d1cc06936e

    • Open Access
    • Data Source
      KAKENHI-PROJECT-19K05693
  • [Journal Article] Chemical Probing of Thymine in the TGG/CGG Triad to Explore the Deamination of 5-Methylcytosine in the CGG Repeat2020

    • Author(s)
      Yagi Yuki、Yamada Takeshi、Nakatani Kazuhiko
    • Journal Title

      Biochemistry

      Volume: 59 Issue: 29 Pages: 2679-2683

    • DOI

      10.1021/acs.biochem.0c00333

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19K05693, KAKENHI-PROJECT-19K22254, KAKENHI-PROJECT-19H00924
  • [Journal Article] Assembly of ruthenium complexes on double stranded DNA using mismatch binding ligands2020

    • Author(s)
      Ni Lu、Yamada Takeshi、Nakatani Kazuhiko
    • Journal Title

      Chemical Communications

      Volume: 56 Issue: 39 Pages: 5227-5230

    • DOI

      10.1039/d0cc01863e

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19K05693, KAKENHI-PROJECT-17K14516
  • [Journal Article] CGG repeat DNA assisted dimerization of CGG/CGG binding molecule through intermolecular disulfide formation2018

    • Author(s)
      Yamada Takeshi、Miki Shouta、Ni Lu、Nakatani Kazuhiko
    • Journal Title

      Chemical Communications

      Volume: 54 Issue: 93 Pages: 13072-13075

    • DOI

      10.1039/c8cc06757k

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K14516, KAKENHI-PROJECT-26000007
  • [Journal Article] Synthesis of Naphthyridine Carbamate Dimer (NCD) Derivatives Modified with Alkanethiol and Binding Properties of G?G Mismatch DNA2017

    • Author(s)
      Yamada Takeshi、Miki Shouta、Ul’Husna Anisa、Michikawa Akiko、Nakatani Kazuhiko
    • Journal Title

      Organic Letters

      Volume: 19 Issue: 16 Pages: 4163-4166

    • DOI

      10.1021/acs.orglett.7b01632

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K14516, KAKENHI-PROJECT-15K17885, KAKENHI-PROJECT-26000007
  • [Presentation] 15N標識ナフチリジン誘導体の合成と性質2022

    • Author(s)
      ○杉浦 徳昭・中谷 和彦・山田 剛史
    • Organizer
      日本化学会第102回春季年会
    • Data Source
      KAKENHI-PROJECT-19K05693
  • [Presentation] NMR study on the binding of naphthyridine dimer to d(CGG) triad2022

    • Author(s)
      ○Shuhei Sakurabayashi, Kyoko Furuita, Takeshi Yamada, Toshimichi Fujiwara, Kazuhiko Nakatani, Chojiro Kojima
    • Organizer
      日本化学会第102回春季年会
    • Data Source
      KAKENHI-PROJECT-19K05693
  • [Presentation] The binding motif of naphthyridine-azaquinolone dimer (NAD) in CAG-repeat RNA2022

    • Author(s)
      ○Qingwen Chen, Takeshi Yamada, Asako Murata, Kazuhiko Nakatani
    • Organizer
      日本化学会第102回春季年会
    • Data Source
      KAKENHI-PROJECT-19K05693
  • [Presentation] Regulation of circular RNA biogenesis via RNA binding small molecule2021

    • Author(s)
      ○Lu Ni, Takeshi Yamada, Asako Murata, Kazuhiko Nakatani
    • Organizer
      日本化学会第101回年会
    • Data Source
      KAKENHI-PROJECT-19K05693
  • [Presentation] Regulation of circular RNA biogenesis using nucleic acid binding small molecule in cellular environment2021

    • Author(s)
      ○Lu Ni, Takeshi Yamada, Asako Murata, Kazuhiko Nakatani
    • Organizer
      Pacificham2021
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K05693
  • [Presentation] Using machine learning to classify and extract features of small-molecule libraries targeting DNA and RNA2021

    • Author(s)
      ○Qingwen Chen, Yasuyuki Matsushita, Asako Murata, Takeshi Yamada, Ayako Sugai, Kazuhiko Nakatani
    • Organizer
      Pacifichem2021
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K05693
  • [Presentation] Regulation of circRNA expression in cell via RNA binding small molecule2021

    • Author(s)
      ○Takeshi YAMADA, Lu Ni, Asako MURATA, Kazuhiko NAKATANI
    • Organizer
      IS3NA-IRT virtual symposium 2021
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K05693
  • [Presentation] Intermediate structure in the binding of naphthyridine dimer to d(CGG) triad revealed by NMR2021

    • Author(s)
      ○Shuhei Sakurabayashi, Kyoko Furuita, Takeshi Yamada, Toshimichi Fujiwara, Kazuhiko Nakatani, and Chojiro Kojima
    • Organizer
      ISNAC2021
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K05693
  • [Presentation] In-cell NMR to investigate the interactions between a hairpin RNA containing a UGGAA/UGGAA pentad and a synthetic small molecule2021

    • Author(s)
      ○Shuhei Sakurabayashi, Qingci Zhao, Takeshi Yamada, Noritaka Nishida, Gota Kawai, Kazuhiko Nakatani
    • Organizer
      Pacifichem2021
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K05693
  • [Presentation] Machine learning-based classification in small molecules targeting CAG-repeat DNA2021

    • Author(s)
      ○Qingwen Chen, Yasuyuki Matsushita, Asako Murata, Takeshi Yamada, Ayako Sugai, Kazuhiko Nakatani
    • Organizer
      FIBER日本核酸化学学会若手フォーラム2021
    • Data Source
      KAKENHI-PROJECT-19K05693
  • [Presentation] Multiplexing ligands through click chemistry at the anomeric site of sugars for oligonucleotide conjugation2021

    • Author(s)
      ○Dhrubajyoti Datta, Takeshi Yamada, Shigeo Matsuda, Muthiah Manoharan
    • Organizer
      IS3NA-IRT virtual symposium 2021
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K05693
  • [Presentation] Computer-aided classification of small molecules targeting CAG-repeat DNA2021

    • Author(s)
      ○Qingwen Chen, Asako Murata, Takeshi Yamada, Ayako Sugai, Yasuyuki Matsushita, Kazuhiko Nakatani
    • Organizer
      ISNAC2021
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K05693
  • [Presentation] Synthesis and the properties of naphthyridine-azaquinolone dimer (NAD) tatgeting CAG-repeat RNA2021

    • Author(s)
      ○Qingwen Chen, Takeshi Yamada, Asako Murata, Kazuhiko Nakatani
    • Organizer
      日本化学会第101回年会
    • Data Source
      KAKENHI-PROJECT-19K05693
  • [Presentation] NMR解析のための13C標識ナフチリジン誘導体の合成2021

    • Author(s)
      ○櫻林 修平、山田 剛史、河合 剛太、中谷 和彦
    • Organizer
      日本化学会第101回年会
    • Data Source
      KAKENHI-PROJECT-19K05693
  • [Presentation] Regulation of circular RNA biogenesis via nucleic acid binding small molecule in cells2021

    • Author(s)
      ○Lu Ni, Takeshi Yamada, Asako Murata, Kazuhiko Nakatani
    • Organizer
      ISNAC2021
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K05693
  • [Presentation] Synthesis and properties of 13C-labeled naphthyridine derivative2020

    • Author(s)
      ○Shuhei Sakurabayashi, Takeshi Yamada, Gota Kawai, Kazuhiko Nakatani
    • Organizer
      日本化学会第100春季年会
    • Data Source
      KAKENHI-PROJECT-19K05693
  • [Presentation] The methylation effect for binding of dimeric 2-amino-1,8-naphthyridine derivatives to CGG/CGG triad in DNA2020

    • Author(s)
      ○Takeshi Yamada, Shuhei Sakurabayashi, Kazuhiko Nakatani
    • Organizer
      The Commemorative International Symposium of the Japan Society of Nucleic Acids Chemistry (CISNAC 2019)
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K14516
  • [Presentation] Structural analysis and functionalization of naphthyridine dimer derivatives bound to CGG repeats2020

    • Author(s)
      ○Takeshi Yamada, Shuhei Sakurabayashi, Kyoko Huruitab, Chojiro Kojima, Kazuhiko Nakatani
    • Organizer
      The 23rd SANKEN INTERNATIONAL SYMPOSIUM
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K05693
  • [Presentation] NMR structural analysis of naphthyridine dimer derivatives binding to CGG/CGG triplets in DNAs2020

    • Author(s)
      ○YAMADA Takeshi
    • Organizer
      2nd Indo-Japan (NCBS/inStem-ISIR, Osaka University) Meeting: Interfacing Chemistry and Biology
    • Invited
    • Data Source
      KAKENHI-PROJECT-19K05693
  • [Presentation] Synthesis and the properties of NA Dimer2020

    • Author(s)
      ◯Chen Qingwen, Yamada Takeshi, Murata Asako, Nakatani Kazuhiko
    • Organizer
      日本化学会第100春季年会
    • Data Source
      KAKENHI-PROJECT-17K14516
  • [Presentation] XGGリピートDNA中のピリミジン塩基を選択的に酸化するリガンドの開発2020

    • Author(s)
      ◯八木 勇樹、山田 剛史、中谷 和彦
    • Organizer
      日本ケミカルバイオロジー学会 第14回年会
    • Data Source
      KAKENHI-PROJECT-17K14516
  • [Presentation] Assembly of ruthenium complexes on dsDNA using mismatch binding ligand2020

    • Author(s)
      ○Lu Ni, Takeshi Yamada, Kazuhiko Nakatani,
    • Organizer
      日本化学会第100春季年会
    • Data Source
      KAKENHI-PROJECT-17K14516
  • [Presentation] Synthesis and the properties of NA Dimer2020

    • Author(s)
      ◯Chen Qingwen, Yamada Takeshi, Murata Asako, Nakatani Kazuhiko
    • Organizer
      日本化学会第100春季年会
    • Data Source
      KAKENHI-PROJECT-19K05693
  • [Presentation] Synthesis and properties of 13C-labeled naphthyridine derivative2020

    • Author(s)
      ○Shuhei Sakurabayashi, Takeshi Yamada, Gota Kawai, Kazuhiko Nakatani
    • Organizer
      日本化学会第100春季年会
    • Data Source
      KAKENHI-PROJECT-17K14516
  • [Presentation] Assembly of ruthenium complexes on dsDNA using mismatch binding ligand2020

    • Author(s)
      ○Lu Ni, Takeshi Yamada, Kazuhiko Nakatani,
    • Organizer
      日本化学会第100春季年会
    • Data Source
      KAKENHI-PROJECT-19K05693
  • [Presentation] Structural analysis and functionalization of naphthyridine dimer derivatives bound to CGG repeats2020

    • Author(s)
      ○Takeshi Yamada, Shuhei Sakurabayashi, Kyoko Huruitab, Chojiro Kojima, Kazuhiko Nakatani
    • Organizer
      The 23rd SANKEN INTERNATIONAL SYMPOSIUM
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K14516
  • [Presentation] NMR structural analysis of naphthyridine dimer derivatives binding to CGG/CGG triplets in DNAs2020

    • Author(s)
      ○YAMADA Takeshi
    • Organizer
      2nd Indo-Japan (NCBS/inStem-ISIR, Osaka University) Meeting: Interfacing Chemistry and Biology
    • Invited
    • Data Source
      KAKENHI-PROJECT-17K14516
  • [Presentation] XGGリピートDNA中のピリミジン塩基を選択的に酸化するリガンドの開発2019

    • Author(s)
      ◯八木 勇樹、山田 剛史、中谷 和彦
    • Organizer
      日本ケミカルバイオロジー学会 第14回年会
    • Data Source
      KAKENHI-PROJECT-19K05693
  • [Presentation] Research on NCD (Naphthyridine Carbamate Dimer) Linked Arene-Ruthenium(II) Half-Sandwich Complexes2019

    • Author(s)
      Ni Lu, Takeshi Yamada
    • Organizer
      日本化学会第99春季年会
    • Data Source
      KAKENHI-PROJECT-17K14516
  • [Presentation] 配列選択的ピリミジン塩基の酸化を指向した、ナフチリジンカルバメートダイマー誘導体の合成とその評価2019

    • Author(s)
      ○八木勇樹、山田剛史、中谷和彦
    • Organizer
      日本化学会第99春季年会
    • Data Source
      KAKENHI-PROJECT-17K14516
  • [Presentation] The methylation effect for binding of dimeric 2-amino-1,8-naphthyridine derivatives to CGG/CGG triad in DNA2019

    • Author(s)
      ○Takeshi Yamada, Shuhei Sakurabayashi, Kazuhiko Nakatani
    • Organizer
      The Commemorative International Symposium of the Japan Society of Nucleic Acids Chemistry (CISNAC 2019)
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K05693
  • [Presentation] 7位修飾ナフチリジンカルバメートダイマーの合成と結合特性2019

    • Author(s)
      櫻林 修平、山田 剛史、中谷 和彦
    • Organizer
      日本化学会第99春季年会
    • Data Source
      KAKENHI-PROJECT-17K14516
  • [Presentation] 金属に配位可能な側鎖をもつアミノ酸で修飾したミスマッチDNA結合性小分子の合成と性質2018

    • Author(s)
      三木 翔太・山田 剛史・中谷 和彦
    • Organizer
      日本化学会第98春季年会
    • Data Source
      KAKENHI-PROJECT-17K14516
  • [Presentation] Repeat DNA assisted dimerization of mismatch binding molecules through intermolecular disul de formation2018

    • Author(s)
      Takeshi Yamada, Kazuhiko Nakatani
    • Organizer
      International Symposium on Nucleic Acids Chemistry (ISNAC) 2018
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K14516
  • [Presentation] 金属に配位可能な側鎖をもつアミノ酸で修飾したミスマッチDNA結合性小分子の合成と性質2018

    • Author(s)
      三木 翔太・山田 剛史・中谷 和彦
    • Organizer
      日本化学会第98春季年会
    • Data Source
      KAKENHI-PROJECT-15K17885
  • [Presentation] Toward site selective modification of pyrimidine bases flipped out by naphthyridine cabamate dimer binding.2018

    • Author(s)
      ○Yuki Yagi, Takeshi Yamada, Kazuhiko Nakatani
    • Organizer
      JSPS日中韓フォーサイト事業 アジア化学プローブ研究拠点 第3回A3若手研究者ミーティング
    • Data Source
      KAKENHI-PROJECT-17K14516
  • [Presentation] Repeat-Assisted Dimerization of Thiol Modified Mismatch Binding Ligand2018

    • Author(s)
      YAMADA Takeshi, NAKATANI Kazuhiko
    • Organizer
      International Roundtable of Nucleosides, Nucleotides, and Nucleic Acids (IRT)
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K14516
  • [Presentation] Functional Regulation of Epigenetic DNA Modifications using Photoreactive Oligonucleotides2018

    • Author(s)
      Asako Yamayoshi, Takayuki Shibata, Yui Sakai, Takeshi Yamada, Tsuyoshi Yamamoto, Takehiko Wada, Kazuhiko Nakatani
    • Organizer
      International Symposium on Nucleic Acids Chemistry (ISNAC) 2018
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K14516
  • [Presentation] Thiol Modified Naphthyridine Carbamate Dimer Accumulated on CGG Repeat DNA2017

    • Author(s)
      ○Takeshi Yamada, Shouta Miki, Kazuhiko Nakatani
    • Organizer
      ISNAC2017
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K14516
  • [Presentation] RNA切断活性をもつミスマッチ結合性リガンドの開発2017

    • Author(s)
      三木 翔太・山田 剛史・中谷 和彦
    • Organizer
      日本化学会第97春季年会
    • Data Source
      KAKENHI-PROJECT-17K14516
  • [Presentation] RNA切断活性をもつミスマッチ結合性リガンドの開発2017

    • Author(s)
      三木翔太、山田剛史、中谷和彦
    • Organizer
      日本化学会第97春期年会
    • Place of Presentation
      慶應義塾大学日吉キャンパス
    • Year and Date
      2017-03-16
    • Data Source
      KAKENHI-PROJECT-15K17885
  • [Presentation] Thiol Modified Naphthyridine Carbamate Dimer Accumulated on CGG Repeat DNA2017

    • Author(s)
      Takeshi Yamada, Shouta Miki, Kazuhiko Nakatani
    • Organizer
      ISNAC2017
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K17885
  • [Presentation] RNA切断活性をもつミスマッチ結合性リガンドの開発2017

    • Author(s)
      三木 翔太・山田 剛史・中谷 和彦
    • Organizer
      日本化学会第97春季年会
    • Data Source
      KAKENHI-PROJECT-15K17885
  • [Presentation] Synthesis and properties of DNA mismatch binding molecules having thiol functional group2016

    • Author(s)
      Yamada, T.; Michikawa, A.; Nakatani, K.
    • Organizer
      日本化学会第96春季年会
    • Place of Presentation
      同志社大京田辺キャンパス、京都
    • Year and Date
      2016-03-24
    • Data Source
      KAKENHI-PROJECT-15K17885
  • [Presentation] Synthesis and properties of functional trinucleotide repeat-binding molecules to induce chemical transformation of trinucleotide repeats2015

    • Author(s)
      Yamada, T.; Michikawa, A.; Nakatani, K.
    • Organizer
      Pacifichem2015
    • Place of Presentation
      Honolulu, Hawaii, US
    • Year and Date
      2015-12-15
    • Data Source
      KAKENHI-PROJECT-15K17885
  • 1.  中谷 和彦 (70237303)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 2.  柴田 知範 (80711960)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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