Yamada Takeshi 山田剛史

Researcher Number	80633263
Other IDs	https://orcid.org/0000-0003-3275-415X
Affiliation (Current)	2023: 東京医科歯科大学, 統合研究機構, 特任講師
Affiliation (based on the past Project Information) *help	2019 – 2022: 大阪大学, 産業科学研究所, 助教 2016 – 2018: 大阪大学, 産業科学研究所, 特任助教(常勤) 2015: 大阪大学, 産業科学研究所, 特任助教
Review Section/Research Field	Principal Investigator Basic Section 37010:Bio-related chemistry / Bio-related chemistry Except Principal Investigator Medium-sized Section 37:Biomolecular chemistry and related fields
Keywords	Principal Investigator 核酸 / RNA / 有機合成 / ケミカルバイオロジー / 低分子 / トリヌクレオチドリピート / ミスマッチ塩基対 / DNA / トリプレットリピート / スプライシング … More / アンチセンスオリゴ / 環状RNA / 分子認識 / オリゴマー / 有機合成化学 / 生体関連化学 / イミダゾール / チオール / ミスマッチ / トリンクレオチドリピート … More Except Principal Investigator 短縮機構解明 / 経路探索 / 結合分子 / ミスマッチ / リピート Less

Elucidation of the binding pathway of mismatch-binding molecules to abnormally elongated repeat sequences and their shortening-inducing effects
- Principal Investigator
  
  中谷和彦
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 37:Biomolecular chemistry and related fields
- Research Institution
  Osaka University
Development of ASOs which up-regulate back-splicing producing circular RNAsPrincipal Investigator
- Principal Investigator
  
  山田剛史
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 37010:Bio-related chemistry
- Research Institution
  Osaka University
Development of small molecules that spontaneously oligomerize on trinucleotide repeatsPrincipal Investigator
- Principal Investigator
  
  YAMADA Takeshi
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 37010:Bio-related chemistry
- Research Institution
  Osaka University
Synthetic study of functional mismatch binding molecules for selective hydrolysis of expanded repeat RNAsPrincipal Investigator
- Principal Investigator
  
  YAMADA Takeshi
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Bio-related chemistry
- Research Institution
  Osaka University
Development of small molecule ligands to inhibit expansion of CAG trinulceotide repeatPrincipal Investigator
- Principal Investigator
  
  Yamada Takeshi
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Bio-related chemistry
- Research Institution
  Osaka University

All 2022 2021 2020 2019 2018 2017 2016 2015

All Journal Article Presentation

[Journal Article] Mismatch binding ligand upregulated back-splicing reaction producing circular RNA in a cellular model2022
- Author(s)
  Ni Lu、Yamada Takeshi、Murata Asako、Nakatani Kazuhiko
- Journal Title
  
  Chemical Communications
  
  Volume: 58 Issue: 22 Pages: 3629-3632
- DOI
  10.1039/d1cc06936e
- Open Access
- Data Source
  KAKENHI-PROJECT-19K05693
[Journal Article] Chemical Probing of Thymine in the TGG/CGG Triad to Explore the Deamination of 5-Methylcytosine in the CGG Repeat2020
- Author(s)
  Yagi Yuki、Yamada Takeshi、Nakatani Kazuhiko
- Journal Title
  
  Biochemistry
  
  Volume: 59 Issue: 29 Pages: 2679-2683
- DOI
  10.1021/acs.biochem.0c00333
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K05693, KAKENHI-PROJECT-19K22254, KAKENHI-PROJECT-19H00924
[Journal Article] Assembly of ruthenium complexes on double stranded DNA using mismatch binding ligands2020
- Author(s)
  Ni Lu、Yamada Takeshi、Nakatani Kazuhiko
- Journal Title
  
  Chemical Communications
  
  Volume: 56 Issue: 39 Pages: 5227-5230
- DOI
  10.1039/d0cc01863e
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K05693, KAKENHI-PROJECT-17K14516
[Journal Article] CGG repeat DNA assisted dimerization of CGG/CGG binding molecule through intermolecular disulfide formation2018
- Author(s)
  Yamada Takeshi、Miki Shouta、Ni Lu、Nakatani Kazuhiko
- Journal Title
  
  Chemical Communications
  
  Volume: 54 Issue: 93 Pages: 13072-13075
- DOI
  10.1039/c8cc06757k
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K14516, KAKENHI-PROJECT-26000007
[Journal Article] Synthesis of Naphthyridine Carbamate Dimer (NCD) Derivatives Modified with Alkanethiol and Binding Properties of G?G Mismatch DNA2017
- Author(s)
  Yamada Takeshi、Miki Shouta、Ul’Husna Anisa、Michikawa Akiko、Nakatani Kazuhiko
- Journal Title
  
  Organic Letters
  
  Volume: 19 Issue: 16 Pages: 4163-4166
- DOI
  10.1021/acs.orglett.7b01632
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K14516, KAKENHI-PROJECT-15K17885, KAKENHI-PROJECT-26000007
[Presentation] 15N標識ナフチリジン誘導体の合成と性質2022
- Author(s)
  ○杉浦徳昭・中谷和彦・山田剛史
- Organizer
  日本化学会第１０２回春季年会
- Data Source
  KAKENHI-PROJECT-19K05693
[Presentation] NMR study on the binding of naphthyridine dimer to d(CGG) triad2022
- Author(s)
  ○Shuhei Sakurabayashi, Kyoko Furuita, Takeshi Yamada, Toshimichi Fujiwara, Kazuhiko Nakatani, Chojiro Kojima
- Organizer
  日本化学会第１０２回春季年会
- Data Source
  KAKENHI-PROJECT-19K05693
[Presentation] The binding motif of naphthyridine-azaquinolone dimer (NAD) in CAG-repeat RNA2022
- Author(s)
  ○Qingwen Chen, Takeshi Yamada, Asako Murata, Kazuhiko Nakatani
- Organizer
  日本化学会第１０２回春季年会
- Data Source
  KAKENHI-PROJECT-19K05693
[Presentation] Regulation of circular RNA biogenesis via RNA binding small molecule2021
- Author(s)
  ○Lu Ni, Takeshi Yamada, Asako Murata, Kazuhiko Nakatani
- Organizer
  日本化学会第１０１回年会
- Data Source
  KAKENHI-PROJECT-19K05693
[Presentation] Regulation of circular RNA biogenesis using nucleic acid binding small molecule in cellular environment2021
- Author(s)
  ○Lu Ni, Takeshi Yamada, Asako Murata, Kazuhiko Nakatani
- Organizer
  Pacificham2021
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K05693
[Presentation] Using machine learning to classify and extract features of small-molecule libraries targeting DNA and RNA2021
- Author(s)
  ○Qingwen Chen, Yasuyuki Matsushita, Asako Murata, Takeshi Yamada, Ayako Sugai, Kazuhiko Nakatani
- Organizer
  Pacifichem2021
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K05693
[Presentation] Regulation of circRNA expression in cell via RNA binding small molecule2021
- Author(s)
  ○Takeshi YAMADA, Lu Ni, Asako MURATA, Kazuhiko NAKATANI
- Organizer
  IS3NA-IRT virtual symposium 2021
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K05693
[Presentation] Intermediate structure in the binding of naphthyridine dimer to d(CGG) triad revealed by NMR2021
- Author(s)
  ○Shuhei Sakurabayashi, Kyoko Furuita, Takeshi Yamada, Toshimichi Fujiwara, Kazuhiko Nakatani, and Chojiro Kojima
- Organizer
  ISNAC2021
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K05693
[Presentation] In-cell NMR to investigate the interactions between a hairpin RNA containing a UGGAA/UGGAA pentad and a synthetic small molecule2021
- Author(s)
  ○Shuhei Sakurabayashi, Qingci Zhao, Takeshi Yamada, Noritaka Nishida, Gota Kawai, Kazuhiko Nakatani
- Organizer
  Pacifichem2021
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K05693
[Presentation] Machine learning-based classification in small molecules targeting CAG-repeat DNA2021
- Author(s)
  ○Qingwen Chen, Yasuyuki Matsushita, Asako Murata, Takeshi Yamada, Ayako Sugai, Kazuhiko Nakatani
- Organizer
  FIBER日本核酸化学学会若手フォーラム2021
- Data Source
  KAKENHI-PROJECT-19K05693
[Presentation] Multiplexing ligands through click chemistry at the anomeric site of sugars for oligonucleotide conjugation2021
- Author(s)
  ○Dhrubajyoti Datta, Takeshi Yamada, Shigeo Matsuda, Muthiah Manoharan
- Organizer
  IS3NA-IRT virtual symposium 2021
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K05693
[Presentation] Computer-aided classification of small molecules targeting CAG-repeat DNA2021
- Author(s)
  ○Qingwen Chen, Asako Murata, Takeshi Yamada, Ayako Sugai, Yasuyuki Matsushita, Kazuhiko Nakatani
- Organizer
  ISNAC2021
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K05693
[Presentation] Synthesis and the properties of naphthyridine-azaquinolone dimer (NAD) tatgeting CAG-repeat RNA2021
- Author(s)
  ○Qingwen Chen, Takeshi Yamada, Asako Murata, Kazuhiko Nakatani
- Organizer
  日本化学会第１０１回年会
- Data Source
  KAKENHI-PROJECT-19K05693
[Presentation] NMR解析のための13C標識ナフチリジン誘導体の合成2021
- Author(s)
  ○櫻林　修平、山田剛史、河合剛太、中谷和彦
- Organizer
  日本化学会第１０１回年会
- Data Source
  KAKENHI-PROJECT-19K05693
[Presentation] Regulation of circular RNA biogenesis via nucleic acid binding small molecule in cells2021
- Author(s)
  ○Lu Ni, Takeshi Yamada, Asako Murata, Kazuhiko Nakatani
- Organizer
  ISNAC2021
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K05693
[Presentation] Synthesis and properties of 13C-labeled naphthyridine derivative2020
- Author(s)
  ○Shuhei Sakurabayashi, Takeshi Yamada, Gota Kawai, Kazuhiko Nakatani
- Organizer
  日本化学会第100春季年会
- Data Source
  KAKENHI-PROJECT-19K05693
[Presentation] The methylation effect for binding of dimeric 2-amino-1,8-naphthyridine derivatives to CGG/CGG triad in DNA2020
- Author(s)
  ○Takeshi Yamada, Shuhei Sakurabayashi, Kazuhiko Nakatani
- Organizer
  The Commemorative International Symposium of the Japan Society of Nucleic Acids Chemistry (CISNAC 2019)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K14516
[Presentation] Structural analysis and functionalization of naphthyridine dimer derivatives bound to CGG repeats2020
- Author(s)
  ○Takeshi Yamada, Shuhei Sakurabayashi, Kyoko Huruitab, Chojiro Kojima, Kazuhiko Nakatani
- Organizer
  The 23rd SANKEN INTERNATIONAL SYMPOSIUM
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K05693
[Presentation] NMR structural analysis of naphthyridine dimer derivatives binding to CGG/CGG triplets in DNAs2020
- Author(s)
  ○YAMADA Takeshi
- Organizer
  2nd Indo-Japan (NCBS/inStem-ISIR, Osaka University) Meeting: Interfacing Chemistry and Biology
- Invited
- Data Source
  KAKENHI-PROJECT-19K05693
[Presentation] Synthesis and the properties of NA Dimer2020
- Author(s)
  ◯Chen Qingwen, Yamada Takeshi, Murata Asako, Nakatani Kazuhiko
- Organizer
  日本化学会第100春季年会
- Data Source
  KAKENHI-PROJECT-17K14516
[Presentation] XGGリピートDNA中のピリミジン塩基を選択的に酸化するリガンドの開発2020
- Author(s)
  ◯八木　勇樹、山田　剛史、中谷　和彦
- Organizer
  日本ケミカルバイオロジー学会第14回年会
- Data Source
  KAKENHI-PROJECT-17K14516
[Presentation] Assembly of ruthenium complexes on dsDNA using mismatch binding ligand2020
- Author(s)
  ○Lu Ni, Takeshi Yamada, Kazuhiko Nakatani,
- Organizer
  日本化学会第100春季年会
- Data Source
  KAKENHI-PROJECT-17K14516
[Presentation] Synthesis and the properties of NA Dimer2020
- Author(s)
  ◯Chen Qingwen, Yamada Takeshi, Murata Asako, Nakatani Kazuhiko
- Organizer
  日本化学会第100春季年会
- Data Source
  KAKENHI-PROJECT-19K05693
[Presentation] Synthesis and properties of 13C-labeled naphthyridine derivative2020
- Author(s)
  ○Shuhei Sakurabayashi, Takeshi Yamada, Gota Kawai, Kazuhiko Nakatani
- Organizer
  日本化学会第100春季年会
- Data Source
  KAKENHI-PROJECT-17K14516
[Presentation] Assembly of ruthenium complexes on dsDNA using mismatch binding ligand2020
- Author(s)
  ○Lu Ni, Takeshi Yamada, Kazuhiko Nakatani,
- Organizer
  日本化学会第100春季年会
- Data Source
  KAKENHI-PROJECT-19K05693
[Presentation] Structural analysis and functionalization of naphthyridine dimer derivatives bound to CGG repeats2020
- Author(s)
  ○Takeshi Yamada, Shuhei Sakurabayashi, Kyoko Huruitab, Chojiro Kojima, Kazuhiko Nakatani
- Organizer
  The 23rd SANKEN INTERNATIONAL SYMPOSIUM
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K14516
[Presentation] NMR structural analysis of naphthyridine dimer derivatives binding to CGG/CGG triplets in DNAs2020
- Author(s)
  ○YAMADA Takeshi
- Organizer
  2nd Indo-Japan (NCBS/inStem-ISIR, Osaka University) Meeting: Interfacing Chemistry and Biology
- Invited
- Data Source
  KAKENHI-PROJECT-17K14516
[Presentation] XGGリピートDNA中のピリミジン塩基を選択的に酸化するリガンドの開発2019
- Author(s)
  ◯八木勇樹、山田剛史、中谷和彦
- Organizer
  日本ケミカルバイオロジー学会第14回年会
- Data Source
  KAKENHI-PROJECT-19K05693
[Presentation] Research on NCD (Naphthyridine Carbamate Dimer) Linked Arene-Ruthenium(II) Half-Sandwich Complexes2019
- Author(s)
  Ni Lu, Takeshi Yamada
- Organizer
  日本化学会第９９春季年会
- Data Source
  KAKENHI-PROJECT-17K14516
[Presentation] 配列選択的ピリミジン塩基の酸化を指向した、ナフチリジンカルバメートダイマー誘導体の合成とその評価2019
- Author(s)
  ○八木勇樹、山田剛史、中谷和彦
- Organizer
  日本化学会第９９春季年会
- Data Source
  KAKENHI-PROJECT-17K14516
[Presentation] The methylation effect for binding of dimeric 2-amino-1,8-naphthyridine derivatives to CGG/CGG triad in DNA2019
- Author(s)
  ○Takeshi Yamada, Shuhei Sakurabayashi, Kazuhiko Nakatani
- Organizer
  The Commemorative International Symposium of the Japan Society of Nucleic Acids Chemistry (CISNAC 2019)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K05693
[Presentation] 7位修飾ナフチリジンカルバメートダイマーの合成と結合特性2019
- Author(s)
  櫻林　修平、山田　剛史、中谷　和彦
- Organizer
  日本化学会第９９春季年会
- Data Source
  KAKENHI-PROJECT-17K14516
[Presentation] 金属に配位可能な側鎖をもつアミノ酸で修飾したミスマッチDNA結合性小分子の合成と性質2018
- Author(s)
  三木　翔太・山田　剛史・中谷　和彦
- Organizer
  日本化学会第９８春季年会
- Data Source
  KAKENHI-PROJECT-17K14516
[Presentation] Repeat DNA assisted dimerization of mismatch binding molecules through intermolecular disul de formation2018
- Author(s)
  Takeshi Yamada, Kazuhiko Nakatani
- Organizer
  International Symposium on Nucleic Acids Chemistry (ISNAC) 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K14516
[Presentation] 金属に配位可能な側鎖をもつアミノ酸で修飾したミスマッチDNA結合性小分子の合成と性質2018
- Author(s)
  三木　翔太・山田　剛史・中谷　和彦
- Organizer
  日本化学会第９８春季年会
- Data Source
  KAKENHI-PROJECT-15K17885
[Presentation] Toward site selective modification of pyrimidine bases flipped out by naphthyridine cabamate dimer binding.2018
- Author(s)
  ○Yuki Yagi, Takeshi Yamada, Kazuhiko Nakatani
- Organizer
  JSPS日中韓フォーサイト事業アジア化学プローブ研究拠点第3回A3若手研究者ミーティング
- Data Source
  KAKENHI-PROJECT-17K14516
[Presentation] Repeat-Assisted Dimerization of Thiol Modified Mismatch Binding Ligand2018
- Author(s)
  YAMADA Takeshi, NAKATANI Kazuhiko
- Organizer
  International Roundtable of Nucleosides, Nucleotides, and Nucleic Acids (IRT)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K14516
[Presentation] Functional Regulation of Epigenetic DNA Modifications using Photoreactive Oligonucleotides2018
- Author(s)
  Asako Yamayoshi, Takayuki Shibata, Yui Sakai, Takeshi Yamada, Tsuyoshi Yamamoto, Takehiko Wada, Kazuhiko Nakatani
- Organizer
  International Symposium on Nucleic Acids Chemistry (ISNAC) 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K14516
[Presentation] Thiol Modified Naphthyridine Carbamate Dimer Accumulated on CGG Repeat DNA2017
- Author(s)
  ○Takeshi Yamada, Shouta Miki, Kazuhiko Nakatani
- Organizer
  ISNAC2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K14516
[Presentation] RNA切断活性をもつミスマッチ結合性リガンドの開発2017
- Author(s)
  三木　翔太・山田　剛史・中谷　和彦
- Organizer
  日本化学会第９７春季年会
- Data Source
  KAKENHI-PROJECT-17K14516
[Presentation] RNA切断活性をもつミスマッチ結合性リガンドの開発2017
- Author(s)
  三木翔太、山田剛史、中谷和彦
- Organizer
  日本化学会第９７春期年会
- Place of Presentation
  慶應義塾大学日吉キャンパス
- Year and Date
  2017-03-16
- Data Source
  KAKENHI-PROJECT-15K17885
[Presentation] Thiol Modified Naphthyridine Carbamate Dimer Accumulated on CGG Repeat DNA2017
- Author(s)
  Takeshi Yamada, Shouta Miki, Kazuhiko Nakatani
- Organizer
  ISNAC2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K17885
[Presentation] RNA切断活性をもつミスマッチ結合性リガンドの開発2017
- Author(s)
  三木　翔太・山田　剛史・中谷　和彦
- Organizer
  日本化学会第９７春季年会
- Data Source
  KAKENHI-PROJECT-15K17885
[Presentation] Synthesis and properties of DNA mismatch binding molecules having thiol functional group2016
- Author(s)
  Yamada, T.; Michikawa, A.; Nakatani, K.
- Organizer
  日本化学会第９６春季年会
- Place of Presentation
  同志社大京田辺キャンパス、京都
- Year and Date
  2016-03-24
- Data Source
  KAKENHI-PROJECT-15K17885
[Presentation] Synthesis and properties of functional trinucleotide repeat-binding molecules to induce chemical transformation of trinucleotide repeats2015
- Author(s)
  Yamada, T.; Michikawa, A.; Nakatani, K.
- Organizer
  Pacifichem2015
- Place of Presentation
  Honolulu, Hawaii, US
- Year and Date
  2015-12-15
- Data Source
  KAKENHI-PROJECT-15K17885

1. 中谷和彦 (70237303)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. 柴田知範 (80711960)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Yamada Takeshi 山田 剛史

Research Projects

Research Products

Co-Researchers

Elucidation of the binding pathway of mismatch-binding molecules to abnormally elongated repeat sequences and their shortening-inducing effects

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of ASOs which up-regulate back-splicing producing circular RNAsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of small molecules that spontaneously oligomerize on trinucleotide repeatsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Synthetic study of functional mismatch binding molecules for selective hydrolysis of expanded repeat RNAsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of small molecule ligands to inhibit expansion of CAG trinulceotide repeatPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Mismatch binding ligand upregulated back-splicing reaction producing circular RNA in a cellular model2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Chemical Probing of Thymine in the TGG/CGG Triad to Explore the Deamination of 5-Methylcytosine in the CGG Repeat2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Assembly of ruthenium complexes on double stranded DNA using mismatch binding ligands2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] CGG repeat DNA assisted dimerization of CGG/CGG binding molecule through intermolecular disulfide formation2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Synthesis of Naphthyridine Carbamate Dimer (NCD) Derivatives Modified with Alkanethiol and Binding Properties of G?G Mismatch DNA2017

Author(s)

Journal Title

DOI

Data Source

[Presentation] 15N標識ナフチリジン誘導体の合成と性質2022

Author(s)

Organizer

Data Source

[Presentation] NMR study on the binding of naphthyridine dimer to d(CGG) triad2022

Author(s)

Organizer

Data Source

[Presentation] The binding motif of naphthyridine-azaquinolone dimer (NAD) in CAG-repeat RNA2022

Author(s)

Organizer

Data Source

[Presentation] Regulation of circular RNA biogenesis via RNA binding small molecule2021

Author(s)

Organizer

Data Source

[Presentation] Regulation of circular RNA biogenesis using nucleic acid binding small molecule in cellular environment2021

Author(s)

Organizer

Data Source

[Presentation] Using machine learning to classify and extract features of small-molecule libraries targeting DNA and RNA2021

Yamada Takeshi 山田剛史