Yamada Takeshi 山田剛史

Researcher Number	80633263
Other IDs	https://orcid.org/0000-0003-3275-415X
Affiliation (Current)	2025: 東京科学大学, 総合研究院, 特任講師
Affiliation (based on the past Project Information) *help	2025: 東京科学大学, 総合研究院, 特任講師 2023: 東京医科歯科大学, 統合研究機構, 特任講師 2019 – 2022: 大阪大学, 産業科学研究所, 助教 2016 – 2018: 大阪大学, 産業科学研究所, 特任助教(常勤) 2015: 大阪大学, 産業科学研究所, 特任助教
Review Section/Research Field	Principal Investigator Basic Section 37010:Bio-related chemistry / Bio-related chemistry Except Principal Investigator Basic Section 52020:Neurology-related / Medium-sized Section 37:Biomolecular chemistry and related fields
Keywords	Principal Investigator 核酸 / RNA / 有機合成 / ケミカルバイオロジー / 低分子 / トリヌクレオチドリピート / ミスマッチ塩基対 / DNA / トリプレットリピート / スプライシング … More / アンチセンスオリゴ / バックスプライシング / アンチセンス / 環状RNA / 分子認識 / オリゴマー / 有機合成化学 / 生体関連化学 / イミダゾール / チオール / ミスマッチ / トリンクレオチドリピート … More Except Principal Investigator 核酸医薬 / siRNA / プリオン病 / 化学修飾 / シトシン / 異常伸長 / DNA / 短縮機構解明 / 経路探索 / 結合分子 / ミスマッチ / スリップアウト構造 / 低分子 / 修復酵素 / リピート Less

siRNAを用いたプリオン病の治療戦略の概念実証基盤研究
- Principal Investigator
  
  桑原宏哉
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  Institute of Science Tokyo
Development of ASOs which up-regulate back-splicing producing circular RNAsPrincipal Investigator
- Principal Investigator
  
  山田剛史
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 37010:Bio-related chemistry
- Research Institution
  Tokyo Medical and Dental University
  Osaka University
Elucidation of the binding pathway of mismatch-binding molecules to abnormally elongated repeat sequences and their shortening-inducing effects
- Principal Investigator
  
  中谷和彦
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 37:Biomolecular chemistry and related fields
- Research Institution
  Osaka University
Development of small molecules that spontaneously oligomerize on trinucleotide repeatsPrincipal Investigator
- Principal Investigator
  
  YAMADA Takeshi
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 37010:Bio-related chemistry
- Research Institution
  Osaka University
Synthetic study of functional mismatch binding molecules for selective hydrolysis of expanded repeat RNAsPrincipal Investigator
- Principal Investigator
  
  YAMADA Takeshi
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Bio-related chemistry
- Research Institution
  Osaka University
Development of small molecule ligands to inhibit expansion of CAG trinulceotide repeatPrincipal Investigator
- Principal Investigator
  
  Yamada Takeshi
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Bio-related chemistry
- Research Institution
  Osaka University

All 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015

All Journal Article Presentation Patent

[Journal Article] A new small molecule DoNA binding to CAG repeat RNA2024
- Author(s)
  Chen Qingwen、Yamada Takeshi、Miyagawa Koichi、Murata Asako、Shoji Mitsuo、Nakatani Kazuhiko
- Journal Title
  
  Bioorganic & Medicinal Chemistry
  
  Volume: 98 Pages: 117580-117580
- DOI
  10.1016/j.bmc.2023.117580
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K05315
[Journal Article] NMR analysis of <sup>15</sup>N-labeled naphthyridine carbamate dimer (NCD) to contiguous CGG/CGG units in DNA2024
- Author(s)
  Yamada Takeshi、Sakurabayashi Shuhei、Sugiura Noriaki、Haneoka Hitoshi、Nakatani Kazuhiko
- Journal Title
  
  Chemical Communications
  
  Volume: 60 Issue: 27 Pages: 3645-3648
- DOI
  10.1039/d4cc00544a
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K05315
[Journal Article] Utility of oligonucleotide in upregulating circular RNA production in a cellular model2024
- Author(s)
  Ni Lu、Yamada Takeshi、Nakatani Kazuhiko
- Journal Title
  
  Scientific Reports
  
  Volume: 14 Pages: 8096-8096
- DOI
  10.21203/rs.3.rs-3849465/v1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K05315
[Journal Article] A machine learning approach toward generating the focused molecule library targeting CAG repeat DNA2024
- Author(s)
  Chen Qingwen、Yamada Takeshi、Murata Asako、Sugai Ayako、Matsushita Yasuyuki、Nakatani Kazuhiko
- Journal Title
  
  Digital Discovery
  
  Volume: 3 Issue: 2 Pages: 243-248
- DOI
  10.1039/d3dd00160a
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K05315
[Journal Article] Mismatch binding ligand upregulated back-splicing reaction producing circular RNA in a cellular model2022
- Author(s)
  Ni Lu、Yamada Takeshi、Murata Asako、Nakatani Kazuhiko
- Journal Title
  
  Chemical Communications
  
  Volume: 58 Issue: 22 Pages: 3629-3632
- DOI
  10.1039/d1cc06936e
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K05693, KAKENHI-PROJECT-22K05315, KAKENHI-PROJECT-19H00924
[Journal Article] NMR determination of the 2:1 binding complex of naphthyridine carbamate dimer (NCD) and CGG/CGG triad in double-stranded DNA2022
- Author(s)
  Yamada Takeshi、Furuita Kyoko、Sakurabayashi Shuhei、Nomura Makoto、Kojima Chojiro、Nakatani Kazuhiko
- Journal Title
  
  Nucleic Acids Research
  
  Volume: 50 Issue: 17 Pages: 9621-9631
- DOI
  10.1093/nar/gkac740
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K05315, KAKENHI-PUBLICLY-22H05536, KAKENHI-PROJECT-20H03191, KAKENHI-PROJECT-19H00924
[Journal Article] Chemical Probing of Thymine in the TGG/CGG Triad to Explore the Deamination of 5-Methylcytosine in the CGG Repeat2020
- Author(s)
  Yagi Yuki、Yamada Takeshi、Nakatani Kazuhiko
- Journal Title
  
  Biochemistry
  
  Volume: 59 Issue: 29 Pages: 2679-2683
- DOI
  10.1021/acs.biochem.0c00333
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K05693, KAKENHI-PROJECT-19K22254, KAKENHI-PROJECT-19H00924
[Journal Article] Assembly of ruthenium complexes on double stranded DNA using mismatch binding ligands2020
- Author(s)
  Ni Lu、Yamada Takeshi、Nakatani Kazuhiko
- Journal Title
  
  Chemical Communications
  
  Volume: 56 Issue: 39 Pages: 5227-5230
- DOI
  10.1039/d0cc01863e
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K05693, KAKENHI-PROJECT-17K14516
[Journal Article] CGG repeat DNA assisted dimerization of CGG/CGG binding molecule through intermolecular disulfide formation2018
- Author(s)
  Yamada Takeshi、Miki Shouta、Ni Lu、Nakatani Kazuhiko
- Journal Title
  
  Chemical Communications
  
  Volume: 54 Issue: 93 Pages: 13072-13075
- DOI
  10.1039/c8cc06757k
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K14516, KAKENHI-PROJECT-26000007
[Journal Article] Synthesis of Naphthyridine Carbamate Dimer (NCD) Derivatives Modified with Alkanethiol and Binding Properties of G?G Mismatch DNA2017
- Author(s)
  Yamada Takeshi、Miki Shouta、Ul’Husna Anisa、Michikawa Akiko、Nakatani Kazuhiko
- Journal Title
  
  Organic Letters
  
  Volume: 19 Issue: 16 Pages: 4163-4166
- DOI
  10.1021/acs.orglett.7b01632
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K14516, KAKENHI-PROJECT-15K17885, KAKENHI-PROJECT-26000007
[Patent] 一本鎖核酸およびその用途2024
- Inventor(s)
  山田剛史, Ni Lu, 中谷和彦
- Industrial Property Rights Holder
  大阪大学
- Industrial Property Rights Type
  特許
- Filing Date
  2024
- Overseas
- Data Source
  KAKENHI-PROJECT-22K05315
[Patent] 一本鎖核酸およびその用途2023
- Inventor(s)
  山田剛史, Ni Lu, 中谷和彦
- Industrial Property Rights Holder
  山田剛史, Ni Lu, 中谷和彦
- Industrial Property Rights Type
  特許
- Filing Date
  2023
- Data Source
  KAKENHI-PROJECT-22K05315
[Presentation] リン酸骨格およびダイナミクスに着目したミスマッチDNA-低分子複合体のNMR解析2024
- Author(s)
  櫻林修平, 古板恭子, 杉浦徳昭, 山田剛史, 藤原敏道, 中谷和彦, 児嶋長次郎
- Organizer
  日本化学会第104春季年会
- Data Source
  KAKENHI-PROJECT-22K05315
[Presentation] NMR determination of the binding mode of naphthyridine carbamate dimer (NCD) to CGG repeat DNA2023
- Author(s)
  山田剛史
- Organizer
  核酸化学若手フォーラム2023
- Data Source
  KAKENHI-PROJECT-22K05315
[Presentation] NMR determination of the binding mode of naphthyridine carbamate dimer (NCD) to CGG repeat DNA2023
- Author(s)
  Takeshi Yamada, Shuhei Sakurabayashi, Noriaki Sugiura, Kyoko Furuita, Chojiro Kojima, Kazuhiko Nakatani
- Organizer
  International symposium on nucleic acid chemistry (ISNAC) 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K05315
[Presentation] Investigating new methods for up-regulating the production of circular RNA using cellular models2023
- Author(s)
  山田剛史, 倪露, 中谷和彦
- Organizer
  日本核酸医薬学会第８回年会
- Data Source
  KAKENHI-PROJECT-22K05315
[Presentation] Predicting Molecular Interactions by Graph Convolutional Neural Networks with Global Features2023
- Author(s)
  Kaito Fukui, Qingwen Chen, Hiroaki Santo, Fumio Okura, Takeshi Yamada, Yasuyuki Matsushita, Kazuhiko Nakatani
- Organizer
  International symposium on nucleic acid chemistry (ISNAC) 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K05315
[Presentation] NMRを用いた15N標識ナフチリジン誘導体のリピートD N Aへの相互作用解析2023
- Author(s)
  山田剛史, 杉浦徳昭, 櫻林修平, 中谷和彦
- Organizer
  日本化学会第103春季年会
- Data Source
  KAKENHI-PROJECT-22K05315
[Presentation] Exploring new methods in regulating circular RNA production using cellular model2023
- Author(s)
  Lu Ni, Takeshi Yamada, Kazuhiko Nakatani
- Organizer
  日本化学会第103春季年会
- Data Source
  KAKENHI-PROJECT-22K05315
[Presentation] ナフチリジン誘導体によるミスマッチ塩基対認識メカニズムのNMR解析2023
- Author(s)
  櫻林修平, 古板恭子, 杉浦徳昭, 山田剛史, 藤原敏道, 中谷和彦, 児嶋長次郎
- Organizer
  日本化学会第103春季年会
- Data Source
  KAKENHI-PROJECT-22K05315
[Presentation] Dynamic features of d(CGG)n recognition mechanism of naphthyridine dimer revealed by NMR2022
- Author(s)
  Shuhei Sakurabayashi, Kyoko Furuita, Takeshi Yamada, Toshimichi Fujiwara, Kazuhiko Nakatani, Chojiro Kojima
- Organizer
  International symposium on nucleic acid chemistry (ISNAC)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K05315
[Presentation] CGG リピート結合薬剤ナフチリジンダイマーによる DNA 認識機構の NMR 解析2022
- Author(s)
  櫻林修平, 古板恭子, 山田剛史, 藤原敏道, 中谷和彦, 児嶋長次郎
- Organizer
  第61回NMR討論会
- Data Source
  KAKENHI-PROJECT-22K05315
[Presentation] Regulating circular RNA production in cellular model using bridging antisense oligonucleotide2022
- Author(s)
  Lu Ni, Takeshi Yamada, Kazuhiko Nakatani
- Organizer
  International symposium on nucleic acid chemistry (ISNAC)
- Data Source
  KAKENHI-PROJECT-22K05315
[Presentation] Regulating circular RNA production in cells using 3-way junction forming antisense oligonucleotide2022
- Author(s)
  Lu Ni, Takeshi Yamada, Asako Murata, Kazuhiko Nakatani
- Organizer
  XXiV International Round Table on Nucleosides, Nucleotides and Nucleic Acids, 2022
- Data Source
  KAKENHI-PROJECT-22K05315
[Presentation] Machine learning assisted classification of small molecules targeting CAG repeat DNA2022
- Author(s)
  Qingwen Chen, Takeshi Yamada, Asako Murata, Yasuyuki Matsushita, Kazuhiko Nakatani
- Organizer
  International symposium on nucleic acid chemistry (ISNAC)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K05315
[Presentation] Synthesis and Properties of Naphthyridine-Azaquinolone Dimer2022
- Author(s)
  Takeshi Yamada, Qingwen Chen, Kazuhiko Nakatani
- Organizer
  International symposium on nucleic acid chemistry (ISNAC)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K05315
[Presentation] 15N標識ナフチリジン誘導体の合成と性質2022
- Author(s)
  ○杉浦徳昭・中谷和彦・山田剛史
- Organizer
  日本化学会第１０２回春季年会
- Data Source
  KAKENHI-PROJECT-19K05693
[Presentation] NMR study on the binding of naphthyridine dimer to d(CGG) triad2022
- Author(s)
  ○Shuhei Sakurabayashi, Kyoko Furuita, Takeshi Yamada, Toshimichi Fujiwara, Kazuhiko Nakatani, Chojiro Kojima
- Organizer
  日本化学会第１０２回春季年会
- Data Source
  KAKENHI-PROJECT-19K05693
[Presentation] The binding motif of naphthyridine-azaquinolone dimer (NAD) in CAG-repeat RNA2022
- Author(s)
  ○Qingwen Chen, Takeshi Yamada, Asako Murata, Kazuhiko Nakatani
- Organizer
  日本化学会第１０２回春季年会
- Data Source
  KAKENHI-PROJECT-19K05693
[Presentation] Regulation of circular RNA biogenesis via RNA binding small molecule2021
- Author(s)
  ○Lu Ni, Takeshi Yamada, Asako Murata, Kazuhiko Nakatani
- Organizer
  日本化学会第１０１回年会
- Data Source
  KAKENHI-PROJECT-19K05693
[Presentation] Regulation of circular RNA biogenesis using nucleic acid binding small molecule in cellular environment2021
- Author(s)
  ○Lu Ni, Takeshi Yamada, Asako Murata, Kazuhiko Nakatani
- Organizer
  Pacificham2021
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K05693
[Presentation] Using machine learning to classify and extract features of small-molecule libraries targeting DNA and RNA2021
- Author(s)
  ○Qingwen Chen, Yasuyuki Matsushita, Asako Murata, Takeshi Yamada, Ayako Sugai, Kazuhiko Nakatani
- Organizer
  Pacifichem2021
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K05693
[Presentation] Regulation of circRNA expression in cell via RNA binding small molecule2021
- Author(s)
  ○Takeshi YAMADA, Lu Ni, Asako MURATA, Kazuhiko NAKATANI
- Organizer
  IS3NA-IRT virtual symposium 2021
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K05693
[Presentation] Intermediate structure in the binding of naphthyridine dimer to d(CGG) triad revealed by NMR2021
- Author(s)
  ○Shuhei Sakurabayashi, Kyoko Furuita, Takeshi Yamada, Toshimichi Fujiwara, Kazuhiko Nakatani, and Chojiro Kojima
- Organizer
  ISNAC2021
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K05693
[Presentation] In-cell NMR to investigate the interactions between a hairpin RNA containing a UGGAA/UGGAA pentad and a synthetic small molecule2021
- Author(s)
  ○Shuhei Sakurabayashi, Qingci Zhao, Takeshi Yamada, Noritaka Nishida, Gota Kawai, Kazuhiko Nakatani
- Organizer
  Pacifichem2021
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K05693
[Presentation] Machine learning-based classification in small molecules targeting CAG-repeat DNA2021
- Author(s)
  ○Qingwen Chen, Yasuyuki Matsushita, Asako Murata, Takeshi Yamada, Ayako Sugai, Kazuhiko Nakatani
- Organizer
  FIBER日本核酸化学学会若手フォーラム2021
- Data Source
  KAKENHI-PROJECT-19K05693
[Presentation] Multiplexing ligands through click chemistry at the anomeric site of sugars for oligonucleotide conjugation2021
- Author(s)
  ○Dhrubajyoti Datta, Takeshi Yamada, Shigeo Matsuda, Muthiah Manoharan
- Organizer
  IS3NA-IRT virtual symposium 2021
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K05693
[Presentation] Computer-aided classification of small molecules targeting CAG-repeat DNA2021
- Author(s)
  ○Qingwen Chen, Asako Murata, Takeshi Yamada, Ayako Sugai, Yasuyuki Matsushita, Kazuhiko Nakatani
- Organizer
  ISNAC2021
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K05693
[Presentation] Synthesis and the properties of naphthyridine-azaquinolone dimer (NAD) tatgeting CAG-repeat RNA2021
- Author(s)
  ○Qingwen Chen, Takeshi Yamada, Asako Murata, Kazuhiko Nakatani
- Organizer
  日本化学会第１０１回年会
- Data Source
  KAKENHI-PROJECT-19K05693
[Presentation] NMR解析のための13C標識ナフチリジン誘導体の合成2021
- Author(s)
  ○櫻林　修平、山田剛史、河合剛太、中谷和彦
- Organizer
  日本化学会第１０１回年会
- Data Source
  KAKENHI-PROJECT-19K05693
[Presentation] Regulation of circular RNA biogenesis via nucleic acid binding small molecule in cells2021
- Author(s)
  ○Lu Ni, Takeshi Yamada, Asako Murata, Kazuhiko Nakatani
- Organizer
  ISNAC2021
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K05693
[Presentation] Synthesis and properties of 13C-labeled naphthyridine derivative2020
- Author(s)
  ○Shuhei Sakurabayashi, Takeshi Yamada, Gota Kawai, Kazuhiko Nakatani
- Organizer
  日本化学会第100春季年会
- Data Source
  KAKENHI-PROJECT-19K05693
[Presentation] The methylation effect for binding of dimeric 2-amino-1,8-naphthyridine derivatives to CGG/CGG triad in DNA2020
- Author(s)
  ○Takeshi Yamada, Shuhei Sakurabayashi, Kazuhiko Nakatani
- Organizer
  The Commemorative International Symposium of the Japan Society of Nucleic Acids Chemistry (CISNAC 2019)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K14516
[Presentation] Structural analysis and functionalization of naphthyridine dimer derivatives bound to CGG repeats2020
- Author(s)
  ○Takeshi Yamada, Shuhei Sakurabayashi, Kyoko Huruitab, Chojiro Kojima, Kazuhiko Nakatani
- Organizer
  The 23rd SANKEN INTERNATIONAL SYMPOSIUM
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K05693
[Presentation] NMR structural analysis of naphthyridine dimer derivatives binding to CGG/CGG triplets in DNAs2020
- Author(s)
  ○YAMADA Takeshi
- Organizer
  2nd Indo-Japan (NCBS/inStem-ISIR, Osaka University) Meeting: Interfacing Chemistry and Biology
- Invited
- Data Source
  KAKENHI-PROJECT-19K05693
[Presentation] Synthesis and the properties of NA Dimer2020
- Author(s)
  ◯Chen Qingwen, Yamada Takeshi, Murata Asako, Nakatani Kazuhiko
- Organizer
  日本化学会第100春季年会
- Data Source
  KAKENHI-PROJECT-17K14516
[Presentation] XGGリピートDNA中のピリミジン塩基を選択的に酸化するリガンドの開発2020
- Author(s)
  ◯八木　勇樹、山田　剛史、中谷　和彦
- Organizer
  日本ケミカルバイオロジー学会第14回年会
- Data Source
  KAKENHI-PROJECT-17K14516
[Presentation] Assembly of ruthenium complexes on dsDNA using mismatch binding ligand2020
- Author(s)
  ○Lu Ni, Takeshi Yamada, Kazuhiko Nakatani,
- Organizer
  日本化学会第100春季年会
- Data Source
  KAKENHI-PROJECT-17K14516
[Presentation] Synthesis and the properties of NA Dimer2020
- Author(s)
  ◯Chen Qingwen, Yamada Takeshi, Murata Asako, Nakatani Kazuhiko
- Organizer
  日本化学会第100春季年会
- Data Source
  KAKENHI-PROJECT-19K05693
[Presentation] Synthesis and properties of 13C-labeled naphthyridine derivative2020
- Author(s)
  ○Shuhei Sakurabayashi, Takeshi Yamada, Gota Kawai, Kazuhiko Nakatani
- Organizer
  日本化学会第100春季年会
- Data Source
  KAKENHI-PROJECT-17K14516
[Presentation] Assembly of ruthenium complexes on dsDNA using mismatch binding ligand2020
- Author(s)
  ○Lu Ni, Takeshi Yamada, Kazuhiko Nakatani,
- Organizer
  日本化学会第100春季年会
- Data Source
  KAKENHI-PROJECT-19K05693
[Presentation] Structural analysis and functionalization of naphthyridine dimer derivatives bound to CGG repeats2020
- Author(s)
  ○Takeshi Yamada, Shuhei Sakurabayashi, Kyoko Huruitab, Chojiro Kojima, Kazuhiko Nakatani
- Organizer
  The 23rd SANKEN INTERNATIONAL SYMPOSIUM
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K14516
[Presentation] NMR structural analysis of naphthyridine dimer derivatives binding to CGG/CGG triplets in DNAs2020
- Author(s)
  ○YAMADA Takeshi
- Organizer
  2nd Indo-Japan (NCBS/inStem-ISIR, Osaka University) Meeting: Interfacing Chemistry and Biology
- Invited
- Data Source
  KAKENHI-PROJECT-17K14516
[Presentation] XGGリピートDNA中のピリミジン塩基を選択的に酸化するリガンドの開発2019
- Author(s)
  ◯八木勇樹、山田剛史、中谷和彦
- Organizer
  日本ケミカルバイオロジー学会第14回年会
- Data Source
  KAKENHI-PROJECT-19K05693
[Presentation] Research on NCD (Naphthyridine Carbamate Dimer) Linked Arene-Ruthenium(II) Half-Sandwich Complexes2019
- Author(s)
  Ni Lu, Takeshi Yamada
- Organizer
  日本化学会第９９春季年会
- Data Source
  KAKENHI-PROJECT-17K14516
[Presentation] 配列選択的ピリミジン塩基の酸化を指向した、ナフチリジンカルバメートダイマー誘導体の合成とその評価2019
- Author(s)
  ○八木勇樹、山田剛史、中谷和彦
- Organizer
  日本化学会第９９春季年会
- Data Source
  KAKENHI-PROJECT-17K14516
[Presentation] The methylation effect for binding of dimeric 2-amino-1,8-naphthyridine derivatives to CGG/CGG triad in DNA2019
- Author(s)
  ○Takeshi Yamada, Shuhei Sakurabayashi, Kazuhiko Nakatani
- Organizer
  The Commemorative International Symposium of the Japan Society of Nucleic Acids Chemistry (CISNAC 2019)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K05693
[Presentation] 7位修飾ナフチリジンカルバメートダイマーの合成と結合特性2019
- Author(s)
  櫻林　修平、山田　剛史、中谷　和彦
- Organizer
  日本化学会第９９春季年会
- Data Source
  KAKENHI-PROJECT-17K14516
[Presentation] 金属に配位可能な側鎖をもつアミノ酸で修飾したミスマッチDNA結合性小分子の合成と性質2018
- Author(s)
  三木　翔太・山田　剛史・中谷　和彦
- Organizer
  日本化学会第９８春季年会
- Data Source
  KAKENHI-PROJECT-17K14516
[Presentation] Repeat DNA assisted dimerization of mismatch binding molecules through intermolecular disul de formation2018
- Author(s)
  Takeshi Yamada, Kazuhiko Nakatani
- Organizer
  International Symposium on Nucleic Acids Chemistry (ISNAC) 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K14516
[Presentation] 金属に配位可能な側鎖をもつアミノ酸で修飾したミスマッチDNA結合性小分子の合成と性質2018
- Author(s)
  三木　翔太・山田　剛史・中谷　和彦
- Organizer
  日本化学会第９８春季年会
- Data Source
  KAKENHI-PROJECT-15K17885
[Presentation] Toward site selective modification of pyrimidine bases flipped out by naphthyridine cabamate dimer binding.2018
- Author(s)
  ○Yuki Yagi, Takeshi Yamada, Kazuhiko Nakatani
- Organizer
  JSPS日中韓フォーサイト事業アジア化学プローブ研究拠点第3回A3若手研究者ミーティング
- Data Source
  KAKENHI-PROJECT-17K14516
[Presentation] Repeat-Assisted Dimerization of Thiol Modified Mismatch Binding Ligand2018
- Author(s)
  YAMADA Takeshi, NAKATANI Kazuhiko
- Organizer
  International Roundtable of Nucleosides, Nucleotides, and Nucleic Acids (IRT)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K14516
[Presentation] Functional Regulation of Epigenetic DNA Modifications using Photoreactive Oligonucleotides2018
- Author(s)
  Asako Yamayoshi, Takayuki Shibata, Yui Sakai, Takeshi Yamada, Tsuyoshi Yamamoto, Takehiko Wada, Kazuhiko Nakatani
- Organizer
  International Symposium on Nucleic Acids Chemistry (ISNAC) 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K14516
[Presentation] Thiol Modified Naphthyridine Carbamate Dimer Accumulated on CGG Repeat DNA2017
- Author(s)
  ○Takeshi Yamada, Shouta Miki, Kazuhiko Nakatani
- Organizer
  ISNAC2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K14516
[Presentation] RNA切断活性をもつミスマッチ結合性リガンドの開発2017
- Author(s)
  三木　翔太・山田　剛史・中谷　和彦
- Organizer
  日本化学会第９７春季年会
- Data Source
  KAKENHI-PROJECT-17K14516
[Presentation] RNA切断活性をもつミスマッチ結合性リガンドの開発2017
- Author(s)
  三木翔太、山田剛史、中谷和彦
- Organizer
  日本化学会第９７春期年会
- Place of Presentation
  慶應義塾大学日吉キャンパス
- Year and Date
  2017-03-16
- Data Source
  KAKENHI-PROJECT-15K17885
[Presentation] Thiol Modified Naphthyridine Carbamate Dimer Accumulated on CGG Repeat DNA2017
- Author(s)
  Takeshi Yamada, Shouta Miki, Kazuhiko Nakatani
- Organizer
  ISNAC2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K17885
[Presentation] RNA切断活性をもつミスマッチ結合性リガンドの開発2017
- Author(s)
  三木　翔太・山田　剛史・中谷　和彦
- Organizer
  日本化学会第９７春季年会
- Data Source
  KAKENHI-PROJECT-15K17885
[Presentation] Synthesis and properties of DNA mismatch binding molecules having thiol functional group2016
- Author(s)
  Yamada, T.; Michikawa, A.; Nakatani, K.
- Organizer
  日本化学会第９６春季年会
- Place of Presentation
  同志社大京田辺キャンパス、京都
- Year and Date
  2016-03-24
- Data Source
  KAKENHI-PROJECT-15K17885
[Presentation] Synthesis and properties of functional trinucleotide repeat-binding molecules to induce chemical transformation of trinucleotide repeats2015
- Author(s)
  Yamada, T.; Michikawa, A.; Nakatani, K.
- Organizer
  Pacifichem2015
- Place of Presentation
  Honolulu, Hawaii, US
- Year and Date
  2015-12-15
- Data Source
  KAKENHI-PROJECT-15K17885

1. 中谷和彦 (70237303)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. 柴田知範 (80711960)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 桑原宏哉 (80723486)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Yamada Takeshi 山田 剛史

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Co-Researchers

siRNAを用いたプリオン病の治療戦略の概念実証基盤研究

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Development of ASOs which up-regulate back-splicing producing circular RNAsPrincipal Investigator

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Elucidation of the binding pathway of mismatch-binding molecules to abnormally elongated repeat sequences and their shortening-inducing effects

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Development of small molecules that spontaneously oligomerize on trinucleotide repeatsPrincipal Investigator

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Synthetic study of functional mismatch binding molecules for selective hydrolysis of expanded repeat RNAsPrincipal Investigator

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Development of small molecule ligands to inhibit expansion of CAG trinulceotide repeatPrincipal Investigator

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[Journal Article] A new small molecule DoNA binding to CAG repeat RNA2024

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[Journal Article] NMR analysis of <sup>15</sup>N-labeled naphthyridine carbamate dimer (NCD) to contiguous CGG/CGG units in DNA2024

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[Journal Article] Utility of oligonucleotide in upregulating circular RNA production in a cellular model2024

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[Journal Article] A machine learning approach toward generating the focused molecule library targeting CAG repeat DNA2024

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[Journal Article] Mismatch binding ligand upregulated back-splicing reaction producing circular RNA in a cellular model2022

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[Journal Article] NMR determination of the 2:1 binding complex of naphthyridine carbamate dimer (NCD) and CGG/CGG triad in double-stranded DNA2022

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[Journal Article] Chemical Probing of Thymine in the TGG/CGG Triad to Explore the Deamination of 5-Methylcytosine in the CGG Repeat2020

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[Journal Article] Assembly of ruthenium complexes on double stranded DNA using mismatch binding ligands2020

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Yamada Takeshi 山田剛史