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Sakaue Hiroaki  坂上 弘明

ORCIDConnect your ORCID iD *help
Researcher Number 80734855
Other IDs
Affiliation (Current) 2023: 国立研究開発法人産業技術総合研究所, 生命工学領域, 研究員
Affiliation (based on the past Project Information) *help 2021: 国立研究開発法人産業技術総合研究所, 生命工学領域, 研究員
2017 – 2021: 東京薬科大学, 薬学部, 助教
2016: 国際医療福祉大学, 薬学部, 助教
Review Section/Research Field
Principal Investigator
Applied health science / Basic Section 59040:Nutrition science and health science-related
Except Principal Investigator
Basic Section 59040:Nutrition science and health science-related
Keywords
Principal Investigator
D-アミノ酸 / アスパラギン酸 / 異性化 / 紫外線 / アスパラギン酸残基の異性化 / タンパク質 / 皮膚バリア機能 / フィラグリン / ショットガンプロテオミクス / 表皮角化細胞 / 天然保湿因子 / アトピー性皮膚炎 … More
Except Principal Investigator
… More 皮膚 / 鬱 / 精神的ストレス / 神経伝達物質 / ざ瘡 / うつ / 紫外線 / 日光 / ドパミン / 太陽光 / 中枢神経 Less
  • Research Projects

    (3 results)
  • Research Products

    (6 results)
  • Co-Researchers

    (5 People)
  •  皮膚バリア機能の維持・向上に対する遊離D-アミノ酸の役割Principal Investigator

    • Principal Investigator
      坂上 弘明
    • Project Period (FY)
      2020 – 2023
    • Research Category
      Grant-in-Aid for Early-Career Scientists
    • Review Section
      Basic Section 59040:Nutrition science and health science-related
    • Research Institution
      National Institute of Advanced Industrial Science and Technology
      Tokyo University of Pharmacy and Life Science
  •  精神的健康増進を目指した太陽光による中枢作用の解明

    • Principal Investigator
      水野 晃治
    • Project Period (FY)
      2019 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 59040:Nutrition science and health science-related
    • Research Institution
      National Center for Geriatrics and Gerontology
      Tokyo University of Pharmacy and Life Science
  •  Investigation of isomerization mechanism of aspartic acid involved in the development of cataractPrincipal Investigator

    • Principal Investigator
      Sakaue Hiroaki
    • Project Period (FY)
      2016 – 2019
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Applied health science
    • Research Institution
      Tokyo University of Pharmacy and Life Science
      International University of Health and Welfare

All 2022 2021 2020 2018 2017

All Journal Article Presentation

  • [Journal Article] Molecular mechanisms of cyclic phosphatidic acid-induced lymphangiogenic actions in vitro2022

    • Author(s)
      Okuyama Katsuki、Mizuno Koji、Nittami Keisuke、Sakaue Hiroaki、Sato Takashi
    • Journal Title

      Microvascular Research

      Volume: 139 Pages: 104273-104273

    • DOI

      10.1016/j.mvr.2021.104273

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K11652
  • [Journal Article] An increase in normetanephrine in hair follicles of acne lesions through the sympatho‐adrenal medullary system in acne patients with anxiety2021

    • Author(s)
      Mizuno Koji、Sakaue Hiroaki、Kohsaka Keita、Takeda Hidetomo、Hayashi Nobukazu、Sato Takashi
    • Journal Title

      The Journal of Dermatology

      Volume: 48 Pages: 1281-1285

    • DOI

      10.1111/1346-8138.15935

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19K11652
  • [Journal Article] D-Alanine Is Reduced by Ocular Hypertension in the Rat Retina.2020

    • Author(s)
      Takashi Kanamoto, Hiroaki Sakaue, Yasushi Kitaoka, Ryo Asaoka, Kei Tobiume, and Yoshiaki Kiuchi
    • Journal Title

      Curr Eye Res.

      Volume: 45 Pages: 490-495

    • DOI

      10.1080/02713683.2019.1666995

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16K16605, KAKENHI-PROJECT-18K09813
  • [Journal Article] D-Amino acids in protein: The mirror of life as a molecular index of aging2018

    • Author(s)
      Fujii Noriko、Takata Takumi、Fujii Norihiko、Aki Kenzo、Sakaue Hiroaki
    • Journal Title

      Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics

      Volume: in press Pages: 840-847

    • DOI

      10.1016/j.bbapap.2018.03.001

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K13221, KAKENHI-PROJECT-16K16605
  • [Journal Article] Isomeric replacement of a single aspartic acid induces a marked change in protein function: the example of ribonuclease A.2017

    • Author(s)
      Sakaue H, Kinouchi T, Fujii N, Takumi T, Fujii N.
    • Journal Title

      ACS Omega.

      Volume: 2 Pages: 260-267

    • DOI

      10.1021/acsomega.6b00346

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-25288075, KAKENHI-PROJECT-15K16514, KAKENHI-PROJECT-16K00600, KAKENHI-PROJECT-16K16605, KAKENHI-PROJECT-17K13221
  • [Presentation] A single aspartyl isomer at a specific site induces a change in protein function.2017

    • Author(s)
      Hiroaki Sakaue
    • Organizer
      The 3rd International Conference of D-Amino Acid Research
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K16605
  • 1.  水野 晃治 (10551046)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 2.  高田 匠
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 3.  木野内 忠稔
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 4.  藤井 紀子
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 5.  飛梅 圭
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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