Sakaue Hiroaki 坂上弘明

Researcher Number	80734855
Other IDs
Affiliation (Current)	2023: 国立研究開発法人産業技術総合研究所, 生命工学領域, 研究員
Affiliation (based on the past Project Information) *help	2021: 国立研究開発法人産業技術総合研究所, 生命工学領域, 研究員 2017 – 2021: 東京薬科大学, 薬学部, 助教 2016: 国際医療福祉大学, 薬学部, 助教
Review Section/Research Field	Principal Investigator Applied health science / Basic Section 59040:Nutrition science and health science-related Except Principal Investigator Basic Section 59040:Nutrition science and health science-related
Keywords	Principal Investigator D-アミノ酸 / アスパラギン酸 / 異性化 / 紫外線 / アスパラギン酸残基の異性化 / タンパク質 / 皮膚バリア機能 / フィラグリン / ショットガンプロテオミクス / 表皮角化細胞 / 天然保湿因子 / アトピー性皮膚炎 … More Except Principal Investigator … More 皮膚 / 鬱 / 精神的ストレス / 神経伝達物質 / ざ瘡 / うつ / 紫外線 / 日光 / ドパミン / 太陽光 / 中枢神経 Less

皮膚バリア機能の維持・向上に対する遊離D-アミノ酸の役割Principal Investigator
- Principal Investigator
  
  坂上弘明
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  National Institute of Advanced Industrial Science and Technology
  Tokyo University of Pharmacy and Life Science
精神的健康増進を目指した太陽光による中枢作用の解明
- Principal Investigator
  
  水野晃治
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  National Center for Geriatrics and Gerontology
  Tokyo University of Pharmacy and Life Science
Investigation of isomerization mechanism of aspartic acid involved in the development of cataractPrincipal Investigator
- Principal Investigator
  
  Sakaue Hiroaki
- Project Period (FY)
  2016 – 2019
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Applied health science
- Research Institution
  Tokyo University of Pharmacy and Life Science
  International University of Health and Welfare

All 2022 2021 2020 2018 2017

All Journal Article Presentation

[Journal Article] Molecular mechanisms of cyclic phosphatidic acid-induced lymphangiogenic actions in vitro2022
- Author(s)
  Okuyama Katsuki、Mizuno Koji、Nittami Keisuke、Sakaue Hiroaki、Sato Takashi
- Journal Title
  
  Microvascular Research
  
  Volume: 139 Pages: 104273-104273
- DOI
  10.1016/j.mvr.2021.104273
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K11652
[Journal Article] An increase in normetanephrine in hair follicles of acne lesions through the sympatho‐adrenal medullary system in acne patients with anxiety2021
- Author(s)
  Mizuno Koji、Sakaue Hiroaki、Kohsaka Keita、Takeda Hidetomo、Hayashi Nobukazu、Sato Takashi
- Journal Title
  
  The Journal of Dermatology
  
  Volume: 48 Pages: 1281-1285
- DOI
  10.1111/1346-8138.15935
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K11652
[Journal Article] D-Alanine Is Reduced by Ocular Hypertension in the Rat Retina.2020
- Author(s)
  Takashi Kanamoto, Hiroaki Sakaue, Yasushi Kitaoka, Ryo Asaoka, Kei Tobiume, and Yoshiaki Kiuchi
- Journal Title
  
  Curr Eye Res.
  
  Volume: 45 Pages: 490-495
- DOI
  10.1080/02713683.2019.1666995
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K16605, KAKENHI-PROJECT-18K09813
[Journal Article] D-Amino acids in protein: The mirror of life as a molecular index of aging2018
- Author(s)
  Fujii Noriko、Takata Takumi、Fujii Norihiko、Aki Kenzo、Sakaue Hiroaki
- Journal Title
  
  Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics
  
  Volume: in press Pages: 840-847
- DOI
  10.1016/j.bbapap.2018.03.001
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K13221, KAKENHI-PROJECT-16K16605
[Journal Article] Isomeric replacement of a single aspartic acid induces a marked change in protein function: the example of ribonuclease A.2017
- Author(s)
  Sakaue H, Kinouchi T, Fujii N, Takumi T, Fujii N.
- Journal Title
  
  ACS Omega.
  
  Volume: 2 Pages: 260-267
- DOI
  10.1021/acsomega.6b00346
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25288075, KAKENHI-PROJECT-15K16514, KAKENHI-PROJECT-16K00600, KAKENHI-PROJECT-16K16605, KAKENHI-PROJECT-17K13221
[Presentation] A single aspartyl isomer at a specific site induces a change in protein function.2017
- Author(s)
  Hiroaki Sakaue
- Organizer
  The 3rd International Conference of D-Amino Acid Research
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K16605

1. 水野晃治 (10551046)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
2. 高田匠

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
3. 木野内忠稔

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. 藤井紀子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. 飛梅圭

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Sakaue Hiroaki 坂上 弘明

Research Projects

Research Products

Co-Researchers

皮膚バリア機能の維持・向上に対する遊離D-アミノ酸の役割Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

精神的健康増進を目指した太陽光による中枢作用の解明

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Investigation of isomerization mechanism of aspartic acid involved in the development of cataractPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Molecular mechanisms of cyclic phosphatidic acid-induced lymphangiogenic actions in vitro2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] An increase in normetanephrine in hair follicles of acne lesions through the sympatho‐adrenal medullary system in acne patients with anxiety2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] D-Alanine Is Reduced by Ocular Hypertension in the Rat Retina.2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] D-Amino acids in protein: The mirror of life as a molecular index of aging2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Isomeric replacement of a single aspartic acid induces a marked change in protein function: the example of ribonuclease A.2017

Author(s)

Journal Title

DOI

Data Source

[Presentation] A single aspartyl isomer at a specific site induces a change in protein function.2017

Author(s)

Organizer

Data Source

Sakaue Hiroaki 坂上弘明