Ono Atsushi 大野敦司

… Alternative Names

ONO ATSUSHI 大野敦司

Less

Researcher Number	80774645
Other IDs
Affiliation (Current)	2026: 広島大学, 医系科学研究科(医), 講師
Affiliation (based on the past Project Information) *help	2024 – 2026: 広島大学, 医系科学研究科(医), 講師 2023: 広島大学, 医系科学研究科(医), 助教 2019 – 2021: 広島大学, 医系科学研究科(医), 助教 2018: 広島大学, 医歯薬保健学研究科(医), 助教 2017: 広島大学, 病院(医), 病院助教
Review Section/Research Field	Principal Investigator Basic Section 53010:Gastroenterology-related / Basic Section 50010:Tumor biology-related / Gastroenterology Except Principal Investigator Basic Section 53010:Gastroenterology-related
Keywords	Principal Investigator 肝細胞癌 / 微小環境 / バイオマーカー / レンバチニブ / 肝癌 / がん免疫 / リンパ球 / 免疫療法 / ベバシズマブ / アテゾリズマブ … More / 癌免疫 / 抗PD-L1抗体 / シンジェニックマウスモデル / 腫瘍免疫 / 腫瘍免疫微小環境 / circulating tumor DNA / 血中循環腫瘍DNA / 肝がん / サイトカイン … More Except Principal Investigator 免疫微小環境 / 空間的RNA解析 / がんゲノム / ゲノム不安定 / シークエンス解析 / 膵がん / 胆道がん / ゲノム / 肝臓がん / 体細胞変異 / 空間的RNA発現解析 / 腫瘍不均一性 / エピゲノム / 空間的発現解析 / 肝胆膵がん / ゲノムシークエンス / 腫瘍免疫 Less

腫瘍微小環境リプログラミングを介した免疫療法増強型併用治療の創薬Principal Investigator
- Principal Investigator
  
  大野敦司
- Project Period (FY)
  2026 – 2028
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Hiroshima University
複合免疫療法による肝癌組織の変化・治療奏効を反映する非侵襲的血液マーカーの探索
- Principal Investigator
  
  河岡友和
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Hiroshima University
Immune-genomics of hepatobiliary cancers
- Principal Investigator
  
  Nakagawa Hidewaki
- Project Period (FY)
  2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Institute of Physical and Chemical Research
Identification of molecules associated with response to atezolizumab plus bevacizumab therapy in hepatocellular carcinomaPrincipal Investigator
- Principal Investigator
  
  大野敦司
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Hiroshima University
A Study of the Effect of Lenvatinib on the Immune Microenvironment of Hepatocellular CarcinomaPrincipal Investigator
- Principal Investigator
  
  Atsushi Ono
- Project Period (FY)
  2020 – 2021
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Hiroshima University
Elucidation of the mechanism of therapeutic resistance in liver cancer using circulating tumor DNAPrincipal Investigator
- Principal Investigator
  
  ONO ATSUSHI
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Gastroenterology
- Research Institution
  Hiroshima University

All 2025 2024 2023 2022 2020 2019

All Journal Article Presentation

[Journal Article] Serum IL-6 concentration is a useful biomarker to predict the efficacy of atezolizumab plus bevacizumab in patients with hepatocellular carcinoma2025
- Author(s)
  Ryoichi Miura, Atsushi Ono, Hikaru Nakahara, Yuki Shirane, Kenji Yamaoka, Yasutoshi Fujii, Shinsuke Uchikawa, Hatsue Fujino, Eisuke Murakami, Tomokazu Kawaoka, Daiki Miki, Masataka Tsuge, Takeshi Kishi, Waka Ohishi, Naoya Sakamoto, Koji Arihiro, Clair Nelson Hayes, Shiro Oka
- Journal Title
  
  J Gastroenterol.
  
  Volume: 60 Issue: 3 Pages: 328-339
- DOI
  10.1007/s00535-024-02185-w
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K07463
[Journal Article] Peripheral T Cell Subpopulations as a Potential Surrogate Biomarker during Atezolizumab plus Bevacizumab Treatment for Hepatocellular Carcinoma2024
- Author(s)
  Shirane Yuki、Fujii Yasutoshi、Ono Atsushi、Nakahara Hikaru、Hayes Clair Nelson、Miura Ryoichi、Murakami Serami、Sakamoto Naoya、Uchikawa Shinsuke、Fujino Hatsue、Nakahara Takashi、Murakami Eisuke、Yamauchi Masami、Miki Daiki、Kawaoka Tomokazu、Arihiro Koji、Tsuge Masataka、Oka Shiro
- Journal Title
  
  Cancers
  
  Volume: 16 Issue: 7 Pages: 1328-1328
- DOI
  10.3390/cancers16071328
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K15582, KAKENHI-PROJECT-23K07463
[Journal Article] Real-world efficacy and safety of durvalumab-tremelimumab as second-line systemic therapy after atezolizumab-bevacizumab in unresectable hepatocellular carcinoma2024
- Author(s)
  Ryoichi Miura, Atsushi Ono, Shigeki Yano, Kei Amioka, Kensuke Naruto, Kenji Yamaoka, Yasutoshi Fujii, Shinsuke Uchikawa, Hatsue Fujino, Takashi Nakahara, Eisuke Murakami, Tomokazu Kawaoka, Daiki Miki, Masataka Tsuge, C Nelson Hayes, Shiro Oka
- Journal Title
  
  Medicine (Baltimore).
  
  Volume: 103 Issue: 34 Pages: e39289-e39289
- DOI
  10.1097/md.0000000000039289
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K07463
[Journal Article] Association of hepatobiliary phase of Gd-EOB-DTPA-enhanced MRI imaging with immune microenvironment and response to atezolizumab plus bevacizumab treatment.2023
- Author(s)
  Tamura Y, Ono A, Nakahara H, Hayes N, Fujii Y, Zhang P, Yamauchi M, Uchikawa S, Kodama K, Teraoka Y, Fujimo H, Nakahara T, Murakami E, Serikawa M, Miki D, Kawaoka T, Okamoto W, Imamura M, Nakamura Y, Awai T, Ohdan H, Fujita M, Nakagawa H, Chayama K, Aikata H, and Oka S
- Journal Title
  
  Cancers
  
  Volume: 15 Issue: 17 Pages: 4234-4234
- DOI
  10.3390/cancers15174234
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K24324
[Journal Article] The presence of vessels encapsulating tumor clusters is associated with an immunosuppressive tumor microenvironment in hepatocellular carcinoma.2022
- Author(s)
  Zhang P, Ono A, Fujii Y, Hayes CN, Tamura Y, Miura R, Shirane Y, Nakahara H, Yamauchi M, Uchikawa S, Uchida T, Teraoka Y, Fujino H, Nakahara T, Murakami E, Miki D, Kawaoka T, Okamoto W, Makokha GN, Imamura M, Arihiro K, Kobayashi T, Ohdan H, Fujita M, Nakagawa H, Chayama K, and Aikata H.
- Journal Title
  
  Int J Cancer.
  
  Volume: 151 Issue: 12 Pages: 2278-2290
- DOI
  10.1002/ijc.34247
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K24324
[Journal Article] Proteo-genomic characterization of virus-associated liver cancers reveals potential subtypes and therapeutic targets2022
- Author(s)
  Fujita Masashi、Chen Mei-Ju May、Siwak Doris Rieko、Sasagawa Shota、Oosawa-Tatsuguchi Ayako、Arihiro Koji、Ono Atsushi、Miura Ryoichi、Maejima Kazuhiro、Aikata Hiroshi、Ueno Masaki、Hayami Shinya、Yamaue Hiroki、Chayama Kazuaki、Lee Ju-Seog、Lu Yiling、Mills Gordon B.、Liang Han、Nishizuka Satoshi S.、Nakagawa Hidewaki
- Journal Title
  
  Nature Communications
  
  Volume: 13 Issue: 1 Pages: 6481-6481
- DOI
  10.1038/s41467-022-34249-x
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K19694, KAKENHI-PROJECT-21H04833, KAKENHI-PROJECT-23K24324
[Journal Article] Comprehensive analysis of full-length transcripts reveals novel splicing abnormalities and oncogenic transcripts in liver cancer2022
- Author(s)
  Kiyose Hiroki、Nakagawa Hidewaki、Ono Atsushi、Aikata Hiroshi、Ueno Masaki、Hayami Shinya、Yamaue Hiroki、Chayama Kazuaki、Shimada Mihoko、Wong Jing Hao、Fujimoto Akihiro
- Journal Title
  
  PLOS Genetics
  
  Volume: 18 Issue: 8 Pages: e1010342-e1010342
- DOI
  10.1371/journal.pgen.1010342
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21H04833, KAKENHI-PROJECT-23K24324
[Journal Article] Circulating cytokines and angiogenic factors based signature associated with the relative dose intensity during treatment in patients with advanced hepatocellular carcinoma receiving lenvatinib2020
- Author(s)
  Ono A, Aikata H, Yamauchi M, Kodama K, Ohishi W, Takeshi K, Ohya K, Teraoka Y, Osawa M, Fujino H, Nakahara T, Murakami E, Miki D, Kawaoka T, Abe-Chayama H, Zhang P, Liu S, Makokha , Tsuge M, Imamura M, Hayes CN, Chayama K
- Journal Title
  
  Therapeutic Advances in Medical Oncology
  
  Volume: in press
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K15948
[Presentation] 切除不能肝細胞癌に対するデュルバルマブ+トレメリムマブ併用療法の有効性と安全性2025
- Author(s)
  大野敦司, 田中愛子, 河岡友和, 江盛智明, 橋本晃, 三田村祐里, 平岡敬一, 上平祐輔, 小坂正成, 白根佑樹, 三浦崚一, 村上せらみ、山岡賢治, 藤井康智, 内川慎介, 藤野初江, 村上英介, 三木大樹, 柘植雅貴, 岡志郎
- Organizer
  第31回日本肝がん分子標的治療研究会
- Data Source
  KAKENHI-PROJECT-23K07463
[Presentation] IL-6 is a useful biomarker for selection of systmic therapies in hepatocellular carcinoma2024
- Author(s)
  Ryoichi Miura, Atsushi Ono, Shigeki Yano, Kei Amioka, Kensuke Naruto, Kenji Yamaoka, Yasutoshi Fujii, Shinsuke Uchikawa, Hatsue Fujino, Takashi Nakahara, Eisuke Murakami, Tomokazu Kawaoka, Daiki Miki, Masataka Tsuge, Shiro Oka
- Organizer
  APASL
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K07463
[Presentation] Predictive Factors for Objective Response Rate in Patients with Unresectable Hepatocellular Carcinoma Treated with Durvalumab Plus Tremelimumab Therapy2024
- Author(s)
  Yuki Shirane, Yasutoshi Fujii, Atsushi Ono, Shinsuke Uchikawa, Hatsue Fujino, Eisuke Murakami, Daiki Miki, Tomokazu Kawaoka, Masataka Tsuge, Shiro Oka
- Organizer
  APASL oncology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K07463
[Presentation] アテゾリズマブ＋ベバシズマブ併用療法後のlater line導入におけるデュルバルマブ＋トレメリムマブ併用療法の安全性と有効性の検討2024
- Author(s)
  三浦崚一, 大野敦司, 白根佑樹, 矢野成樹, 網岡慶, 鳴戸謙輔, 山岡賢治, 藤井康智, 内川慎介.　藤野初江, 村上英介, 河岡友和, 柘植雅貴, 岡　志郎
- Organizer
  第28回日本肝臓学会大会
- Data Source
  KAKENHI-PROJECT-23K07463
[Presentation] 切除不能肝細胞癌に対する一時薬物療法選択のための非侵襲的治療バイオマーカーの探索2024
- Author(s)
  三浦峻一, 大野敦司, 白根佑樹, 矢野成樹, 網岡　慶, 鳴戸謙輔, 山岡賢治, 藤井康智, 内川慎介, 河岡友和, 柘植雅貴, 岡　志郎
- Organizer
  第29回日本肝がん分子標的薬研究会
- Data Source
  KAKENHI-PROJECT-23K07463
[Presentation] アテゾリズマブ+ベバシズマブ併用療法後の複合免疫療法リチャレンジとしてのデュルバルマブ+トレメリムマブ併用療法の安全性と有効性の検討2024
- Author(s)
  三浦峻一, 大野敦司, 岡　志郎
- Organizer
  第60回日本肝臓学会総会
- Data Source
  KAKENHI-PROJECT-23K07463
[Presentation] 切除不能肝細胞癌に対するアテゾリズマブ+ベバシズマブ併用療法の奏効性に関わる血清サイトカインの探索2024
- Author(s)
  大野敦司, 三浦崚一, 白根佑樹, 山岡賢治, 藤井康智, 内川慎介, 藤野初江, 村上英介, 河岡友和, 三木大樹, 柘植雅貴, 岡志郎
- Organizer
  第60回日本肝臓学会総会
- Data Source
  KAKENHI-PROJECT-23K07463
[Presentation] 進行肝細胞癌に対するAtezolizumab+Bevacizumab治療前の末梢T細胞サブポピュレーションの解析～治療効果との関連に着目して～2023
- Author(s)
  白根佑樹、藤井康智、大野敦司、柘植雅貴、岡志郎
- Organizer
  第8回Gastro-PLUS
- Data Source
  KAKENHI-PROJECT-23K07463
[Presentation] 肝細胞癌に対するatezolizumab+bevacizumab治療効果予測のバイオマーカーとなりうる末梢T細胞サブポピュレーション2023
- Author(s)
  白根佑樹、大野敦司、岡　志郎
- Organizer
  第45回日本肝臓学会西部会
- Data Source
  KAKENHI-PROJECT-23K07463
[Presentation] Lenvatinib activates potential anti-tumor immunity by increasing infiltration of immune cells and interferon response in tumor microenvironment of advanced hepatocellular carcinoma2022
- Author(s)
  Yamauchi Masami, Atsushi Ono, et al.
- Organizer
  ESMO 24th World Congress on Gastrointestinal Cancer
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K16332
[Presentation] 進行肝癌におけるレンバチニブ治療のバイオマーカーの探索,2019
- Author(s)
  大野　敦司
- Organizer
  第56回日本臨床分子医学会学術集会
- Data Source
  KAKENHI-PROJECT-17K15948
[Presentation] 進行肝癌におけるレンバチニブ治療のバイオマーカーの探索2019
- Author(s)
  大野　敦司
- Organizer
  第56回　日本臨床分子医学会学術集会
- Data Source
  KAKENHI-PROJECT-17K15948
[Presentation] EXPLORATORY ANALYSIS OF BIOMARKERS ASSOCIATED WITH CLINICAL OUTCOMES OF LENVATINIB IN HEPATOCELLULAR CARCINOMA2019
- Author(s)
  Atsushi Ono, Hiroshi Aikata, Masami Yamauchi, Kenichiro Kodama, Daiki Miki, Waka Ohishi, Yuji Teraoka, Hatsue Fujino, Takashi Nakahara, Eisuke Murakami, Tomokazu Kawaoka, Hiromi Abe-Chayama, Masataka Tsuge, Michio Imamura, Clair Nelson Hayes, Kazuaki Chayama
- Organizer
  The Liver Meeting 2019, American Association for the Study of Liver Diseases
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K15948

1. Nakagawa Hidewaki (50361621)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
2. 中村透 (70645796)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
3. 相方浩 (30403512)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
4. 河岡友和 (80727115)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 山上裕機

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
6. 速水晋也

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 山内理海

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Ono Atsushi 大野 敦司

ONO ATSUSHI 大野 敦司

Research Projects

Research Products

Co-Researchers

腫瘍微小環境リプログラミングを介した免疫療法増強型併用治療の創薬Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

複合免疫療法による肝癌組織の変化・治療奏効を反映する非侵襲的血液マーカーの探索

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Immune-genomics of hepatobiliary cancers

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Identification of molecules associated with response to atezolizumab plus bevacizumab therapy in hepatocellular carcinomaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

A Study of the Effect of Lenvatinib on the Immune Microenvironment of Hepatocellular CarcinomaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of the mechanism of therapeutic resistance in liver cancer using circulating tumor DNAPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Serum IL-6 concentration is a useful biomarker to predict the efficacy of atezolizumab plus bevacizumab in patients with hepatocellular carcinoma2025

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Peripheral T Cell Subpopulations as a Potential Surrogate Biomarker during Atezolizumab plus Bevacizumab Treatment for Hepatocellular Carcinoma2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Real-world efficacy and safety of durvalumab-tremelimumab as second-line systemic therapy after atezolizumab-bevacizumab in unresectable hepatocellular carcinoma2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Association of hepatobiliary phase of Gd-EOB-DTPA-enhanced MRI imaging with immune microenvironment and response to atezolizumab plus bevacizumab treatment.2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The presence of vessels encapsulating tumor clusters is associated with an immunosuppressive tumor microenvironment in hepatocellular carcinoma.2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Proteo-genomic characterization of virus-associated liver cancers reveals potential subtypes and therapeutic targets2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Comprehensive analysis of full-length transcripts reveals novel splicing abnormalities and oncogenic transcripts in liver cancer2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Circulating cytokines and angiogenic factors based signature associated with the relative dose intensity during treatment in patients with advanced hepatocellular carcinoma receiving lenvatinib2020

Author(s)

Journal Title

Data Source

Ono Atsushi 大野敦司

ONO ATSUSHI 大野敦司

[Presentation] 切除不能肝細胞癌に対するデュルバルマブ+トレメリムマブ併用療法の有効性と安全性2025

[Presentation] 進行肝細胞癌に対するAtezolizumab+Bevacizumab治療前の末梢T細胞サブポピュレーションの解析～治療効果との関連に着目して～2023