Okamoto Akinao 岡本晃直

… Alternative Names

Akinao Okamoto 岡本晃直

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Researcher Number	80775049
Affiliation (Current)	2025: 藤田医科大学, 医学部, 講師
Affiliation (based on the past Project Information) *help	2018 – 2024: 藤田医科大学, 医学部, 講師
Review Section/Research Field	Principal Investigator Basic Section 54010:Hematology and medical oncology-related / Basic Section 52010:General internal medicine-related Except Principal Investigator Basic Section 58020:Hygiene and public health-related: including laboratory approach
Keywords	Principal Investigator 不明熱 / 悪性リンパ腫 / リキッドバイオプシー / NGS / Droplet digital PCR / Liquid biopsy / 血管内リンパ腫 / リキッド・バイオプシー / droplet digital PCR / liquid biopsy / Lymphoma / cell free DNA / Oncology … More Except Principal Investigator … More 液性免疫 / SARS-CoV-2 Less

多角的なSARS-CoV-2免疫獲得状況の調査研究
- Principal Investigator
  
  藤垣英嗣
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 58020:Hygiene and public health-related: including laboratory approach
- Research Institution
  Fujita Health University
悪性リンパ腫疑い不明熱患者に対するリキッドバイオプシーによる診断法の確立Principal Investigator
- Principal Investigator
  
  岡本晃直
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Fujita Health University
Liquid Biopsy for the Diagnosis of Malignant Lymphoma in Patients with Fever of Unknown OriginPrincipal Investigator
- Principal Investigator
  
  Akinao Okamoto
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 52010:General internal medicine-related
- Research Institution
  Fujita Health University

All 2024 2023 2022 2021 2020 2019 2018 2017

All Journal Article Presentation Patent

[Journal Article] EBV+ nodal T/NK-cell lymphoma associated with clonal hematopoiesis and structural variations of the viral genome2024
- Author(s)
  Kato Seiichi、Hamada Motoharu、Okamoto Akinao、Yamashita Daisuke、Miyoshi Hiroaki、Arai Haruto、Satou Akira、Gion Yuka、Sato Yasuharu、Tsuyuki Yuta、Miyata-Takata Tomoko、Takata Katsuyoshi、Asano Naoko、Takahashi Emiko、Ohshima Koichi、Tomita Akihiro、Hosoda Waki、Nakamura Shigeo、Okuno Yusuke
- Journal Title
  
  Blood Advances
  
  Volume: Epub Issue: 9 Pages: 2138-2147
- DOI
  10.1182/bloodadvances.2023012019
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K08381, KAKENHI-PROJECT-21K06920, KAKENHI-PROJECT-21K08407, KAKENHI-PROJECT-23K21374, KAKENHI-PROJECT-23K24140
[Journal Article] Antibody response after third dose of COVID-19 mRNA vaccination in allogeneic hematopoietic stem cell transplant recipients is comparable to that in healthy counterparts2023
- Author(s)
  Takagi Erina、Terakura Seitaro、Fujigaki Hidetsugu、Okamoto Akinao、Miyao Kotaro、Sawa Masashi、Morishita Takanobu、Goto Tatsunori、Ozawa Yukiyasu、Nishida Tetsuya、Fukushima Nobuaki、Ozeki Kazutaka、Hanajiri Ryo、Saito Kuniaki、Murata Makoto、Tomita Akihiro、Kiyoi Hitoshi
- Journal Title
  
  International Journal of Hematology
  
  Volume: 118 Issue: 4 Pages: 462-471
- DOI
  10.1007/s12185-023-03648-1
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K15323, KAKENHI-PROJECT-21K08381, KAKENHI-PROJECT-22K08501, KAKENHI-PROJECT-21K08387, KAKENHI-PROJECT-21K08407, KAKENHI-PROJECT-23K27624, KAKENHI-PROJECT-23K27843
[Journal Article] Five-year follow-up of a phase II study of DA-EPOCH-R with high-dose MTX in CD5-positive DLBCL.2023
- Author(s)
  Miyazaki Kana、Sakai Rika、Iwaki Noriko、et al.
- Journal Title
  
  Cancer Science
  
  Volume: - Issue: 6 Pages: 2689-2691
- DOI
  10.1111/cas.15784
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K08479, KAKENHI-PROJECT-21K08381
[Journal Article] Utility of cerebrospinal fluid liquid biopsy in distinguishing <scp>CNS</scp> lymphoma from cerebrospinal infectious/demyelinating diseases2023
- Author(s)
  Iriyama Chisako、Murate Kenichiro、Iba Sachiko、Okamoto Akinao、Goto Naoe、Yamamoto Hideyuki、Kato Toshiharu、Mihara Keichiro、Miyama Takahiko、Hattori Keiko、Kajiya Ryoko、Okamoto Masataka、Mizutani Yasuaki、Yamada Seiji、Tsukamoto Tetsuya、Hirose Yuichi、Mutoh Tatsuro、Watanabe Hirohisa、Tomita Akihiro
- Journal Title
  
  Cancer Medicine
  
  Volume: 12 Issue: 16 Pages: 16972-16984
- DOI
  10.1002/cam4.6329
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K08381, KAKENHI-PROJECT-21K07446, KAKENHI-PROJECT-21K08407, KAKENHI-PROJECT-23K24297
[Journal Article] Acute fulminant intravascular hemolysis induced by Clostridium perfringens in a symptomatic multiple myeloma patient under immuno-chemotherapy2022
- Author(s)
  Yamamoto Hideyuki、Mizutani Yuki、Iriyama Chisako、Goto Naoe、Okamoto Akinao、Kato Toshiharu、Shintani Chiyo、Yamamoto Naoki、Miyama Takahiko、Mihara Keichiro、Okamoto Masataka、Tomita Akihiro
- Journal Title
  
  Annals of Hematology
  
  Volume: 101 Issue: 12 Pages: 2813-2815
- DOI
  10.1007/s00277-022-05010-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K08381, KAKENHI-PROJECT-21K08407, KAKENHI-PROJECT-23K24297
[Journal Article] CD19-positive lymphocyte count is critical for acquisition of anti-SARS-CoV-2 IgG after vaccination in B-cell lymphoma2022
- Author(s)
  Okamoto Akinao、Fujigaki Hidetsugu、Iriyama Chisako、Goto Naoe、Yamamoto Hideyuki、Mihara Keichiro、Inaguma Yoko、Miura Yasuo、Furukawa Katsuya、Yamamoto Yukiya、Akatsuka Yoshiki、Kasahara Senji、Miyao Kotaro、Kajiya Ryoko、Okamoto Masataka、Saito Kuniaki、Tomita Akihiro
- Journal Title
  
  Blood Advances
  
  Volume: 6 Issue: 11 Pages: 3230-3233
- DOI
  10.1182/bloodadvances.2021006302
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K08381, KAKENHI-PROJECT-21K08407, KAKENHI-PROJECT-22K11891, KAKENHI-PROJECT-23K24297
[Journal Article] Correction to: Detection of circulating tumor DNA in cerebrospinal fluid prior to diagnosis of spinal cord lymphoma by flow cytometric and cytologic analyses2021
- Author(s)
  Iriyama Chisako、Murate Kenichiro、Iba Sachiko、Okamoto Akinao、Yamamoto Hideyuki、Kanbara Ayana、Sato Akane、Iwata Emiko、Yamada Ryuta、Okamoto Masataka、Watanabe Hirohisa、Mutoh Tatsuro、Tomita Akihiro
- Journal Title
  
  Annals of Hematology
  
  Volume: 101 Issue: 5 Pages: 1161-1162
- DOI
  10.1007/s00277-021-04722-6
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K08381
[Journal Article] Frequent genetic alterations in immune checkpoint-related genes in intravascular large B-cell lymphoma2021
- Author(s)
  Shimada Kazuyuki、Yoshida Kenichi、Suzuki Yasuhiro、Iriyama Chisako、Inoue Yoshikage、Sanada Masashi、Kataoka Keisuke、Yuge Masaaki、Takagi Yusuke、Kusumoto Shigeru、Masaki Yasufumi、Ito Takahiko、Inagaki Yuichiro、Okamoto Akinao、Kuwatsuka Yachiyo、Nakatochi Masahiro、Shimada Satoko、Miyoshi Hiroaki et al.
- Journal Title
  
  Blood
  
  Volume: 137 Issue: 11 Pages: 1491-1502
- DOI
  10.1182/blood.2020007245
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K08751, KAKENHI-PROJECT-19H05656, KAKENHI-PROJECT-18K15402, KAKENHI-PROJECT-21K08407, KAKENHI-PROJECT-21K16279
[Journal Article] Predictive and risk factor analysis for bloodstream infection in high-risk hematological patients with febrile neutropenia: post-hoc analysis from a prospective, large-scale clinical study2021
- Author(s)
  Okamoto Akinao、Kanda Yoshinobu、Kimura Shun-ichi、Oyake Tatsuo、Tamura Kazuo、from the Japan Febrile Neutropenia Study Group
- Journal Title
  
  International Journal of Hematology
  
  Volume: 114 Issue: 4 Pages: 472-482
- DOI
  10.1007/s12185-021-03183-x
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K08381
[Journal Article] D-Index-Guided Early Antifungal Therapy Versus Empiric Antifungal Therapy for Persistent Febrile Neutropenia: A Randomized Controlled Noninferiority Trial.2020
- Author(s)
  Kanda Y1, Kimura S, Iino M, Fukuda T, Sakaida E, Oyake T, Yamaguchi H, Fujiwara SI, Jo Y, Okamoto A, Fujita H, Takamatsu Y, Saburi Y, Matsumura I, Yamanouchi J, Shiratori S, Gotoh M, Nakamura S, Tamura K
- Journal Title
  
  J Clin Oncol.
  
  Volume: Epub Issue: 8 Pages: 815-822
- DOI
  10.1200/jco.19.01916
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K15402
[Journal Article] Truncated RUNX1 generated from the　fusion of RUNX1 to antisense GRIK2 via a cryptic chromosome translocation enhances　sensitivity　to granulocyte colony-stimulating factor2020
- Author(s)
  Abe A, Yamamoto Y, Katsumi A, Yamamoto H, Okamoto A, Inaguma Y, Iriyama C, Tokuda M, Okamoto M, Emi N, Tomita A.
- Journal Title
  
  Cytogenetic and Genome Research
  
  Volume: - Issue: 5 Pages: 255-263
- DOI
  10.1159/000508012
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K09860, KAKENHI-PROJECT-19K08853, KAKENHI-PROJECT-18K15402
[Journal Article] Epstein-Barr virus (EBV)-positive diffuse large B-cell lymphoma arising in patient with a history of EBV-positive mucocutaneous ulcer and EBV-positive nodal polymorphous B-lymphoproliferative disorder2019
- Author(s)
  Daroontum T, Kohno K, Inaguma Y, Okamoto A, Okamoto M, Kimura Y, Nagahama M, Sakakibara A, Satou A, Nakamura S
- Journal Title
  
  Pathology International
  
  Volume: 69 Issue: 1 Pages: 37-41
- DOI
  10.1111/pin.12738
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K15402
[Journal Article] Role of exosomes as a proinflammatory mediator in the development of EBV-associated lymphoma.2018
- Author(s)
  Higuchi H, Yamakawa N, Imadome KI, Yahata T, Kotaki R, Ogata J, Kakizaki M, Fujita K, Lu J, Yokoyama K, Okuyama K, Sato A, Takamatsu M, Kurosaki N, Alba SM, Azhim A, Horie R, Watanabe T, Kitamura T, Ando K, Kashiwagi T, Matsui T, Okamoto A, Handa H, Kuroda M, Nakamura N, Kotani A.
- Journal Title
  
  Blood
  
  Volume: 131 Issue: 23 Pages: 2552-2567
- DOI
  10.1182/blood-2017-07-794529
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08728, KAKENHI-PROJECT-18K15402, KAKENHI-PROJECT-17H04067, KAKENHI-PROJECT-17H04212
[Journal Article] Rearrangement of VPS13B, a causative gene of Cohen syndrome, in a case of RUNX1-RUNX1T1 leukemia with t(8;12;21).2017
- Author(s)
  Abe A, Yamamoto Y, Katsumi A, Okamoto A, Tokuda M, Inaguma Y, Yamamoto K, Yanada M, Kanie T, Tomita A, Akatsuka Y, Okamoto M, Kameyama T, Mayeda A, Emi N.
- Journal Title
  
  Int J Hematol.
  
  Volume: - Issue: 2 Pages: 208-212
- DOI
  10.1007/s12185-017-2387-x
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K09451, KAKENHI-PROJECT-15K09473, KAKENHI-PROJECT-17K07182, KAKENHI-PROJECT-26460259, KAKENHI-PROJECT-18K15402, KAKENHI-PROJECT-16K09860
[Patent] 不明熱患者のＢ細胞リンパ腫診断補助キットおよび情報提供方法2022
- Inventor(s)
  岡本晃直
- Industrial Property Rights Holder
  岡本晃直
- Industrial Property Rights Type
  特許
- Filing Date
  2022
- Data Source
  KAKENHI-PROJECT-21K08381
[Patent] 不明熱患者のB細胞リンパ腫診断補助キットおよび情報提供方法2022
- Inventor(s)
  岡本晃直
- Industrial Property Rights Holder
  学校法人　藤田学園
- Industrial Property Rights Type
  特許
- Filing Date
  2022
- Acquisition Date
  2024
- Data Source
  KAKENHI-PROJECT-21K08381
[Presentation] Prospective Study of the Usefulness of Liquid Biopsy in Patients with Unknown Fever Suspected of Malignant Lymphoma2022
- Author(s)
  Akinao Okamoto, Masashi Sanada, Takahiko Yasuda, Seiichi Kato, Akihiro Tomita et al.
- Organizer
  64th ASH Annual Meeting and Exposition
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K08381
[Presentation] Liquid biopsy for suspicious lymphoma patients with fever of unknown origin2022
- Author(s)
  Akinao Okamoto, Masashi Sanada, Takahiko Yasuda, Seiichi Kato, Akihiro Tomita et al.
- Organizer
  第84回日本血液学会総会
- Data Source
  KAKENHI-PROJECT-21K08381
[Presentation] Liquid biopsyが補助診断に有効であった血管内大細胞型B細胞リンパ腫の一例2021
- Author(s)
  岡本晃直、真田昌、齊藤繁紀、伊庭佐知子、齊藤統子、山本秀行、徳田倍将、水野紘樹、後藤尚江、入山智沙子、中村栄男、冨田章裕
- Organizer
  第61回　リンパ網内系学会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K15402
[Presentation] 初発時の遺伝子変異解析が病型診断に有用であったろ胞性ヘルパーT細胞表現型を有するPTCLの１例2021
- Author(s)
  加藤駿晴、岡本晃直、入山智沙子、安田貴彦、後藤尚絵、加留部謙之介、三好寛明、眞田昌、堀部敬三、冨田章裕
- Organizer
  第10回　日本血液学会東海地方会
- Data Source
  KAKENHI-PROJECT-18K15402
[Presentation] Detection of central nervous system lymphomas by genetic analyses using cerebrospinal fluid2020
- Author(s)
  Chisako Iriyama，Kennichiro Murate，Sachiko Iba，Akinao Okamoto， Hideyuki Yamamoto，Masutaka Tokuda，Yukiya Yamamoto， Masataka Okamoto，Hirohisa Watanabe，Akihiro Tomita
- Organizer
  第82回　日本血液学会
- Data Source
  KAKENHI-PROJECT-18K15402
[Presentation] Detailed Assessment of Blood Culture and Clinical Factors in Febrile Neutropenia Patients with High-Risk Hematological Malignancy in Japan: A Subgroup Analysis of the Cedmic Trial2020
- Author(s)
  Okamoto A, Kanda Y, Kimura SI, Oyake T, Tamura K
- Organizer
  62nd ASH Annual Meeting and Exposition
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K15402
[Presentation] 髄液のフローサイトメトリーおよび遺伝子検査が診断に有用であった脊髄B細胞性悪性リンパ腫の一例2019
- Author(s)
  齋藤聡一郎，入山智沙子，村手健一郎，武藤多津郎，佐藤あかね，神原彩那，岡本晃直，稲熊容子，岡部麻子，山田勢至，浦野誠，金田典雄，恵美宜彦，岡本昌隆，冨田章裕
- Organizer
  日本リンパ網内系学会
- Data Source
  KAKENHI-PROJECT-18K15402
[Presentation] 中枢浸潤リンパ腫において，髄液中可溶性IL-2Rは上昇する2019
- Author(s)
  岡本晃直，入山智沙子，稲熊容子，岡本昌隆，冨田章裕
- Organizer
  日本リンパ網内系学会
- Data Source
  KAKENHI-PROJECT-18K15402

1. 真田昌 (20529044)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
2. 安田貴彦 (20723977)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
3. 加藤省一 (30584669)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
4. 藤垣英嗣 (00612631)

# of Collaborated Projects: 1 results

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5. 山本康子 (00331869)

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6. 近藤征史 (00378077)

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7. 長谷川みどり (40298518)

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8. 成瀬寛之 (50319266)

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9. 坪井直毅 (50566958)

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10. 古関竹直 (70850551)

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11. 齋藤邦明 (80262765)

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12. 伊藤弘康 (80373075)

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13. 冨田章裕 (80378215)

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14. KATSUMI Akira

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15. HORIE Ryouichi

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16. 葉名尻良

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17. 山本幸也

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18. 安部明弘

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19. 恵美宣彦

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20. 島田和之

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Okamoto Akinao 岡本 晃直

Akinao Okamoto 岡本 晃直

Research Projects

Research Products

Co-Researchers

多角的なSARS-CoV-2免疫獲得状況の調査研究

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

悪性リンパ腫疑い不明熱患者に対するリキッドバイオプシーによる診断法の確立Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Liquid Biopsy for the Diagnosis of Malignant Lymphoma in Patients with Fever of Unknown OriginPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] EBV+ nodal T/NK-cell lymphoma associated with clonal hematopoiesis and structural variations of the viral genome2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Antibody response after third dose of COVID-19 mRNA vaccination in allogeneic hematopoietic stem cell transplant recipients is comparable to that in healthy counterparts2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Five-year follow-up of a phase II study of DA-EPOCH-R with high-dose MTX in CD5-positive DLBCL.2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Utility of cerebrospinal fluid liquid biopsy in distinguishing <scp>CNS</scp> lymphoma from cerebrospinal infectious/demyelinating diseases2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Acute fulminant intravascular hemolysis induced by Clostridium perfringens in a symptomatic multiple myeloma patient under immuno-chemotherapy2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] CD19-positive lymphocyte count is critical for acquisition of anti-SARS-CoV-2 IgG after vaccination in B-cell lymphoma2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Correction to: Detection of circulating tumor DNA in cerebrospinal fluid prior to diagnosis of spinal cord lymphoma by flow cytometric and cytologic analyses2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Frequent genetic alterations in immune checkpoint-related genes in intravascular large B-cell lymphoma2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Predictive and risk factor analysis for bloodstream infection in high-risk hematological patients with febrile neutropenia: post-hoc analysis from a prospective, large-scale clinical study2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] D-Index-Guided Early Antifungal Therapy Versus Empiric Antifungal Therapy for Persistent Febrile Neutropenia: A Randomized Controlled Noninferiority Trial.2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Truncated RUNX1 generated from the fusion of RUNX1 to antisense GRIK2 via a cryptic chromosome translocation enhances sensitivity to granulocyte colony-stimulating factor2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Epstein-Barr virus (EBV)-positive diffuse large B-cell lymphoma arising in patient with a history of EBV-positive mucocutaneous ulcer and EBV-positive nodal polymorphous B-lymphoproliferative disorder2019

Author(s)

Okamoto Akinao 岡本晃直

Akinao Okamoto 岡本晃直

[Journal Article] Truncated RUNX1 generated from the　fusion of RUNX1 to antisense GRIK2 via a cryptic chromosome translocation enhances　sensitivity　to granulocyte colony-stimulating factor2020

[Presentation] 髄液のフローサイトメトリーおよび遺伝子検査が診断に有用であった脊髄B細胞性悪性リンパ腫の一例2019