Fukumoto Takeshi 福本毅

Researcher Number	80778770
Other IDs
Affiliation (Current)	2025: 神戸大学, 医学研究科, 准教授
Affiliation (based on the past Project Information) *help	2023 – 2024: 神戸大学, 医学研究科, 准教授 2022: 神戸大学, 大学院医学研究科, 准教授 2020 – 2022: 神戸大学, 医学部附属病院, 助教
Review Section/Research Field	Principal Investigator Basic Section 53050:Dermatology-related Except Principal Investigator Basic Section 53050:Dermatology-related / Medium-sized Section 52:General internal medicine and related fields / Basic Section 50010:Tumor biology-related
Keywords	Principal Investigator バイオマーカー / 悪性黒色腫 / メラノーマ / 悪性黒色種 / エピゲノム制御 / グルタミン代謝 / 低分子代謝 / トランスオミクス / マルチオミクス / メタボロミクス … More / エクソーム解析 / メラノーマ代謝 / がん代謝 / 薬剤耐性 / 細胞老化 / ARID / ヒストン脱アセチル化酵素 / 小胞体ストレス応答 / エピジェネティクス / グリコーゲン合成酵素キナーゼ-3阻害剤 / cyclin E / Wnt / NOTCH / 皮膚がん / NUMB / NOTCHシグナル / HDAC / 腫瘍免疫 / がん化進展 / ARID2 / SWI/SNF複合体 … More Except Principal Investigator クローン性増殖 / 汗孔角化症 / 細胞競合 / シンクロトロン / 悪性黒色腫 / 白色X線 / 超高線量率X線 / SASP / ARID2 / 細胞老化 / エピゲノム / メラノーマ / エピゲノム変異 / モザイク疾患 / 空間的増殖 / 変異クローン / 体細胞変異 / がん関連遺伝子 / 正常組織 / モザイク / セカンドヒット / 血管腫 / コレステロール生合成 / 原因遺伝子 / セカンドヒット変異 / 苔癬型免疫反応 / コレステロール / メバロン酸経路 / 前癌状態 Less

一次繊毛のエピゲノム制御に着目した悪性黒色腫のBRAF阻害剤耐性獲得機序の解明Principal Investigator
- Principal Investigator
  
  福本毅
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53050:Dermatology-related
- Research Institution
  Kobe University
多発血管腫に着目した皮膚血管内皮「セカンドヒット病」の探索と新規原因遺伝子の同定
- Principal Investigator
  
  小野竜輔
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53050:Dermatology-related
- Research Institution
  Kobe University
Novel strategy for cancer using ultra high dose rate X-ray radiation
- Principal Investigator
  
  佐々木良平
- Project Period (FY)
  2024 – 2027
- Research Category
  
  Fund for the Promotion of Joint International Research (International Collaborative Research)
- Review Section
  
  Medium-sized Section 52:General internal medicine and related fields
- Research Institution
  Kobe University
Gene-environment interactions inducing spatial expansion of mutant clones in human normal tissues
- Principal Investigator
  
  中岡博史
- Project Period (FY)
  2023 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Sasaki Foundation
Understanding the mechanism of cell competition and clonal expansion in porokeratosis to develop novel therapeutics
- Principal Investigator
  
  久保亮治
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 53050:Dermatology-related
- Research Institution
  Kobe University
エピゲノムによる細胞老化制御から読み解くメラノサイトの恒常性破綻と発がん機構
- Principal Investigator
  
  藤原進
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53050:Dermatology-related
- Research Institution
  Kobe University
Potential pathogenesis and novel therapeutic targets by focusing on epigenomic regulation of small molecule metabolism in melanomaPrincipal Investigator
- Principal Investigator
  
  Fukumoto Takeshi
- Project Period (FY)
  2022 – 2023
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 53050:Dermatology-related
- Research Institution
  Kobe University
Novel cancer therapeutic strategy focusing on drug resistance via epigenetic regulation on endoplasmic reticulum stress responsePrincipal Investigator
- Principal Investigator
  
  Fukumoto Takeshi
- Project Period (FY)
  2020 – 2021
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 53050:Dermatology-related
- Research Institution
  Kobe University
Pathophysiology of porokeratosis and cell competition in human
- Principal Investigator
  
  Kubo Akiharu
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 53050:Dermatology-related
- Research Institution
  Kobe University
  Keio University

All 2024 2023 2022 2021 2020

All Journal Article Presentation

[Journal Article] Immune checkpoint inhibitors for metastatic uveal melanoma: a meta-analysis2024
- Author(s)
  Yamada Kayoko、Takeuchi Masaki、Fukumoto Takeshi、Suzuki Minako、Kato Ai、Mizuki Yuki、Yamada Norihiro、Kaneko Takeshi、Mizuki Nobuhisa、Horita Nobuyuki
- Journal Title
  
  Scientific Reports
  
  Volume: 14 Issue: 1 Pages: 7887-7887
- DOI
  10.1038/s41598-024-55675-5
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K16262
[Journal Article] DNA repair ability in a patient with voriconazole-related squamous cell carcinoma that required differential diagnosis from xeroderma pigmentosum2024
- Author(s)
  Fukumoto Takeshi、Harada Tomoka、Ito Takamichi、Fukushima Satoshi、Ono Ryusuke、Furue Masutaka、Nishigori Chikako
- Journal Title
  
  Journal of Dermatological Science
  
  Volume: - Issue: 2 Pages: 00028-8
- DOI
  10.1016/j.jdermsci.2024.02.005
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K08351, KAKENHI-PROJECT-22K16262
[Journal Article] Chemo-Senolytic Therapeutic Potential against Angiosarcoma2024
- Author(s)
  Wang Xuebing、Yik-Lok Chung Claire、Yoshioka Ai、Hashimoto Shinya、Jimbo Haruki、Tanizawa Hideki、Ohta Shinya、Fukumoto Takeshi、Noma Ken-ichi
- Journal Title
  
  Journal of Investigative Dermatology
  
  Volume: 24 Issue: 10 Pages: 00268-9
- DOI
  10.1016/j.jid.2024.03.026
- Data Source
  KAKENHI-PROJECT-22K16262
[Journal Article] CD4/CD8 double‐negative T‐cell lymphoma successfully treated with a combination of bexarotene and total skin electron beam therapy2023
- Author(s)
  Tanigawa Ayano、Fukumoto Takeshi、Imamura Shinya、Nakamura Korefumi、Tanaka Tomonori、Itoh Tomoo、Nakano Eiji、Nishigori Chikako、Kubo Akiharu
- Journal Title
  
  The Journal of Dermatology
  
  Volume: － Issue: 7
- DOI
  10.1111/1346-8138.16739
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K16262, KAKENHI-PROJECT-23K15268
[Journal Article] Adverse events induced by nivolumab and ipilimumab combination regimens2022
- Author(s)
  Somekawa Kohei、Horita Nobuyuki、Kaneko Ayami、Tagami Yoichi、Fukuda Nobuhiko、Matsumoto Hiromi、Namkoong Ho、Fujiwara Yu、Minegishi Kaoru、Fukumoto Takeshi、Watanabe Keisuke、Hara Yu、Kobayashi Nobuaki、Kaneko Takeshi
- Journal Title
  
  Therapeutic Advances in Medical Oncology
  
  Volume: 14
- DOI
  10.1177/17588359211058393
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K17349
[Journal Article] The best dosage of nivolumab plus ipilimumab combination for melanoma brain metastases2022
- Author(s)
  Fukumoto Takeshi、Horita Nobuyuki
- Journal Title
  
  Translational Oncology
  
  Volume: 22 Pages: 101449-101449
- DOI
  10.1016/j.tranon.2022.101449
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K16262
[Journal Article] Severe and delayed-onset acneiform eruptions as an adverse reaction to regorafenib2022
- Author(s)
  Otsuka Haruhiko、Fukumoto Takeshi、Kiyota Naomi、Takemori Chihiro、Jimbo Haruki、Nishigori Chikako
- Journal Title
  
  Dermatology Reports
  
  Volume: 14 Issue: 2
- DOI
  10.4081/dr.2022.9303
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K16262
[Journal Article] NUMB as a Therapeutic Target for Melanoma2021
- Author(s)
  Hristova DM, Fukumoto T, Takemori C, Gao L, Hua X, Wang JX, Li L, Beqiri M, Watters A, Vultur A, Gimie Y, Rebecca V, Samarkina A, Jimbo H, Nishigori C, Zhang J, Cheng C, Wei Z, Somasundaram R, Fukunaga-Kalabis M, Herlyn M
- Journal Title
  
  Journal of Investigative Dermatology
  
  Volume: - Issue: 7 Pages: 1882-1892.e5
- DOI
  10.1016/j.jid.2021.11.027
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K17349
[Journal Article] Single or dual immune checkpoint inhibitor as adjuvant therapy in advanced melanoma2021
- Author(s)
  Fukumoto Takeshi、Horita Nobuyuki
- Journal Title
  
  European Journal of Cancer
  
  Volume: 147 Pages: 140-141
- DOI
  10.1016/j.ejca.2021.01.031
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K17349
[Journal Article] Basal cell carcinoma developed from an epidermal cyst: A case report and review of the literature2021
- Author(s)
  Harada Tomoka、Fukumoto Takeshi、Shimizu Hideki、Nishigori Chikako
- Journal Title
  
  Dermatology Reports
  
  Volume: 13 Issue: 2
- DOI
  10.4081/dr.2021.9273
- NAID
  120007131928
- Data Source
  KAKENHI-PROJECT-20K17349
[Journal Article] Topical imiquimod‐induced lichenoid drug reaction successfully treated with tacrolimus ointment2020
- Author(s)
  Furuoka Keiko、Fukumoto Takeshi、Nagai Hiroshi、Nishigori Chikako
- Journal Title
  
  Dermatologic Therapy
  
  Volume: 33 Issue: 6
- DOI
  10.1111/dth.14480
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K17349
[Journal Article] ARID2 Deficiency Correlates with the Response to Immune Checkpoint Blockade in Melanoma2020
- Author(s)
  Fukumoto Takeshi、Lin Jianhuang、Fatkhutdinov Nail、Liu Pingyu、Somasundaram Rajasekharan、Herlyn Meenhard、Zhang Rugang、Nishigori Chikako
- Journal Title
  
  Journal of Investigative Dermatology
  
  Volume: － Issue: 6 Pages: 1564-1572.e4
- DOI
  10.1016/j.jid.2020.11.026
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K17349
[Presentation] Imatinibが奏功した　KIT　p.Asn655Lys変異を伴う粘膜悪性黒色腫の一例2023
- Author(s)
  八木田隼啓、新川衣里子、福本毅、藤原進、大郷真理子、柴田慶子、久保亮治、金原　史郎、南　博信
- Organizer
  第39回日本皮膚悪性腫瘍学会学術大会
- Data Source
  KAKENHI-PROJECT-22K16262
[Presentation] 老化メラノサイトでのホメオスタシスの変化2023
- Author(s)
  福本毅
- Organizer
  第5回　日本白斑学会学術大会
- Invited
- Data Source
  KAKENHI-PROJECT-22K16262
[Presentation] 露光部に有棘細胞癌を多発し色素性乾皮症を疑われたボリコナゾール長期内服例2023
- Author(s)
  後藤　彩、原田朋佳、福本　毅、小野竜輔、伊東孝通、福島聡、古江増隆、錦織千佳子、久保亮治
- Organizer
  第122回日本皮膚科学会総会
- Data Source
  KAKENHI-PROJECT-22K16262
[Presentation] Seeds for new therapeutic strategies of malignant melanoma2023
- Author(s)
  Takeshi Fukumoto Mizuho Fukunaga-Kalabis, Rajasekharan Somasundaram, Akiharu Kubo, Chikako Nishigori, Rugang Zhang, and Meenhard Herlyn
- Organizer
  25th International Pigment Cell Conference
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K16262
[Presentation] 基底細胞癌を合併し診断に苦慮した脂腺腫の1例2023
- Author(s)
  大幡万里恵、福本毅、後藤彩、新川衣里子、藤原進、吉岡愛育、神保直江、久保亮治
- Organizer
  第39回日本皮膚悪性腫瘍学会学術大会
- Data Source
  KAKENHI-PROJECT-22K16262
[Presentation] The landscape of genetic alterations of UVB-induced skin tumors in DNA repair-deficient mice2022
- Author(s)
  Ai Yoshioka, Hirofumi Nakaoka, Takeshi Fukumoto, Ituro Inoue, Chikako Nishigori, Akiharu Kubo, Makoto Kunisada
- Organizer
  第47回日本研究皮膚科学会学術大会
- Data Source
  KAKENHI-PROJECT-22K16262
[Presentation] Epigenetic regulation in melanocytes differentiated from induced pruripotent stem cells originated from xeroderma pigmentosum2021
- Author(s)
  Chihiro Takemori, Takeshi Fukumoto, Michiyo Koyanagi-Aoi, Makoto Kunisada, Chieko Hosaka, Takashi Aoi, Chikako Nishigori
- Organizer
  第46回日本研究皮膚科学会学術大会
- Data Source
  KAKENHI-PROJECT-20K17349
[Presentation] NUMB inhibits melanoma migration, invasion, and metastasis2021
- Author(s)
  Takeshi Fukumoto, Denitsa M. Hristova, Xia Hua, Haruki Jimbo, Chihiro Takemori, Chikako Nishigori, Zhi Wei, Rajasekharan Somasundaram, Mizuho Fukunaga-Kalabis, Meenhard Herlyn
- Organizer
  第46回日本研究皮膚科学会学術大会
- Data Source
  KAKENHI-PROJECT-20K17349
[Presentation] 小胞体ストレス応答を介する薬剤耐性のエピゲノム制御に着目した悪性黒色腫の個別化治療2021
- Author(s)
  福本毅
- Organizer
  第17回加齢皮膚医学研究会
- Invited
- Data Source
  KAKENHI-PROJECT-20K17349
[Presentation] ベキサロテン内服と全身皮膚電子線照射療法の併用が奏効したCD4陰性CD8陰性皮膚T細胞リンパ腫の1例2021
- Author(s)
  高橋和嘉子、福本毅、谷川絢乃、中村維文、中野英司、国定充、錦織千佳子、田中伴典、伊藤智雄
- Organizer
  第72回日本皮膚科学会中部支部学術大会
- Data Source
  KAKENHI-PROJECT-20K17349
[Presentation] The role of NUMB in melanoma2021
- Author(s)
  Takeshi Fukumoto, Denitsa M. Hristova, Xia Hua, Haruki Jimbo, Chihiro Takemori, Chikako Nishigori, Zhi Wei, Rajasekharan Somasundaram, Mizuho Fukunaga-Kalabis, Meenhard Herlyn
- Organizer
  The 50th European Society for Dermatological Research Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K17349
[Presentation] 24か月間の投与後に発症したRegorafenibによるざ瘡様皮疹と考えられた1例2021
- Author(s)
  川村真実、大塚晴彦、福本毅、清田尚臣、竹森千尋、神保晴紀、錦織千佳子、久保亮治
- Organizer
  第487回日本皮膚科学会大阪地方会
- Data Source
  KAKENHI-PROJECT-20K17349
[Presentation] ベキサロテン内服と全身皮膚電子線照射療法の併用が奏功したCD４/CD８ double-negative T-cell lymphomaの１例2021
- Author(s)
  福本毅、谷川彩乃、錦織千佳子、田中伴典、伊藤智雄
- Organizer
  第2回関西皮膚リンパ腫症例検討会
- Data Source
  KAKENHI-PROJECT-20K17349
[Presentation] 放射線治療の照射領域とその周辺領域に複数の基底細胞癌を発症した1例2020
- Author(s)
  大塚晴彦、福本毅、藤原進、坂口正展、岡昌宏、錦織千佳子
- Organizer
  第113回近畿皮膚科集談会
- Data Source
  KAKENHI-PROJECT-20K17349
[Presentation] AT-rich interactive domain 2 regulates therapeutic antitumor immunity in melanoma2020
- Author(s)
  Takeshi Fukumoto, Jianhuang Lin, Nail Fatkhutdinov, Rajasekharan Somasundaram, Meenhard Herlyn, Rugang Zhang and Chikako Nishigori
- Organizer
  The 24th International Pigment Cell Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K17349

1. Kubo Akiharu (70335256)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
2. 久保亜紀子 (50455573)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
3. 藤原進 (40645389)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. 高橋勇人 (40398615)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 藤田春美 (30736971)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 小野竜輔 (50595486)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 吉岡愛育 (60988228)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 中岡博史 (70611193)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 椙村春彦 (00196742)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 吉原弘祐 (40547535)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 国定充 (80566969)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 須田一暁 (80650621)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 後藤明輝 (90317090)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 佐々木良平 (30346267)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 椋本成俊 (70634278)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 城鮎美 (60707446)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 川口弘毅 (60781820)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 中山雅央 (60582004)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. FUKUSHIMA Satoshi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Fukumoto Takeshi 福本 毅

Research Projects

Research Products

Co-Researchers

一次繊毛のエピゲノム制御に着目した悪性黒色腫のBRAF阻害剤耐性獲得機序の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

多発血管腫に着目した皮膚血管内皮「セカンドヒット病」の探索と新規原因遺伝子の同定

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Novel strategy for cancer using ultra high dose rate X-ray radiation

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Gene-environment interactions inducing spatial expansion of mutant clones in human normal tissues

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Understanding the mechanism of cell competition and clonal expansion in porokeratosis to develop novel therapeutics

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

エピゲノムによる細胞老化制御から読み解くメラノサイトの恒常性破綻と発がん機構

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Potential pathogenesis and novel therapeutic targets by focusing on epigenomic regulation of small molecule metabolism in melanomaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Novel cancer therapeutic strategy focusing on drug resistance via epigenetic regulation on endoplasmic reticulum stress responsePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Pathophysiology of porokeratosis and cell competition in human

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Immune checkpoint inhibitors for metastatic uveal melanoma: a meta-analysis2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] DNA repair ability in a patient with voriconazole-related squamous cell carcinoma that required differential diagnosis from xeroderma pigmentosum2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Chemo-Senolytic Therapeutic Potential against Angiosarcoma2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] CD4/CD8 double‐negative T‐cell lymphoma successfully treated with a combination of bexarotene and total skin electron beam therapy2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Adverse events induced by nivolumab and ipilimumab combination regimens2022

Author(s)

Fukumoto Takeshi 福本毅

[Presentation] Imatinibが奏功した　KIT　p.Asn655Lys変異を伴う粘膜悪性黒色腫の一例2023