Ideguchi Hidetaka 井手口英隆

Researcher Number	80779421
Other IDs
Affiliation (based on the past Project Information) *help	2023: 岡山大学, 歯学部, 博士研究員 2021 – 2022: 岡山大学, 医歯薬学域, 助教 2020: 岡山大学, 医歯薬学総合研究科, 助教 2016 – 2017: 岡山大学, 医歯薬学総合研究科, 助教
Review Section/Research Field	Principal Investigator Basic Section 57020:Oral pathobiological science-related / 0907:Oral science and related fields / Periodontology Except Principal Investigator Basic Section 57030:Conservative dentistry-related / Periodontology
Keywords	Principal Investigator HMGB1 / 歯周炎 / Th17細胞 / 補体経路 / Th17 / 補体 / T細胞 / 炎症性サイトカイン / マクロファージ / M1マクロファージ … More / 炎症性疾患 / 歯周病治療 / 歯学 / 歯周病治療薬 / 抗炎症作用 / ナノDDS / HighMobilityGroupBox1 / 分子イメージング / HighMobilityGroupBox 1 / ドラッグデリバリーシステム / 分子標的薬 / 歯周病 … More Except Principal Investigator レゾルビン / vital pulp therapy / 生活歯髄断髄法 / レゾルビンD2 / マイクロRNA / プロテオーム / 侵襲性歯周炎 / 細胞外小胞 / 遺伝子 / 免疫学 / 歯学 / 抗体療法 / 炎症性サイトカイン / 歯周炎 / 好中球 / 歯肉上皮細胞 / マクロファージ / HMGB1 / サイトカイン / 歯周病 / 炎症 Less

永久歯の感染性歯髄炎への抗炎症物質RvD2応用によるVital Pulp Therapy有効性の検討
- Principal Investigator
  
  伊東有希 (信田有希)
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57030:Conservative dentistry-related
- Research Institution
  Okayama University
Periodontal pathology derived from crosstalk between complement and Th17 cells and novel treatment conceptsPrincipal Investigator
- Principal Investigator
  
  IDEGUCHI Hidetaka
- Project Period (FY)
  2022 – 2023
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 57020:Oral pathobiological science-related
- Research Institution
  Okayama University
細胞外小胞の口腔トロピズムを基軸とする侵襲性歯周炎の病態解明と診断への応用展開
- Principal Investigator
  
  山本直史
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 57030:Conservative dentistry-related
- Research Institution
  Okayama University
Immunological Effects of HMGB1 on Periodontal Disease and Novel Periodontal Disease Treatment by HMGB1 RegulationPrincipal Investigator
- Principal Investigator
  
  Ideguchi Hidetaka
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Review Section
  
  0907:Oral science and related fields
- Research Institution
  Okayama University
Control of periodontal inflammation by anti-inflammatory molecular targeting drug applied with nano drug delivery systemPrincipal Investigator
- Principal Investigator
  
  Ideguchi Hidetaka
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Periodontology
- Research Institution
  Okayama University
Functional analysis of HMGB1 as an inflammatory mediator in periodontitis
- Principal Investigator
  
  YAMASHIRO KEISUKE
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Periodontology
- Research Institution
  Okayama University

All 2023 2022 2021 2020 2018 2017 2016

All Journal Article Presentation

[Journal Article] Ligneous periodontitis exacerbated by Beh?et’s disease in a patient with plasminogen deficiency and a stop-gained variant PLG c.1468C?>?T: a case report2023
- Author(s)
  Shinoda-Ito Yuki、Hirai Anna、Omori Kazuhiro、Ideguchi Hidetaka、Yamamoto Hideki、Kato Fumino、Obata Kyoichi、Ogawa Tatsuo、Nakano Keisuke、Nakadoi Takato、Katsuyama Eri、Ibaragi Soichiro、Yamamoto Tadashi、Nagatsuka Hitoshi、Hirasawa Akira、Takashiba Shogo
- Journal Title
  
  BMC Oral Health
  
  Volume: 23 Issue: 1 Pages: 843-843
- DOI
  10.1186/s12903-023-03586-8
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K17014, KAKENHI-PROJECT-23K20333
[Journal Article] The Fungal Metabolite (+)-Terrein Abrogates Inflammatory Bone Resorption via the Suppression of TNF-α Production in a Ligature-Induced Periodontitis Mouse Model2023
- Author(s)
  Sako Hidefumi、Omori Kazuhiro、Nakayama Masaaki、Mandai Hiroki、Ideguchi Hidetaka、Yoshimura-Nakagawa Saki、Sakaida Kyosuke、Nagata-Kamei Chiaki、Kobayashi Hiroya、Ishii Satoki、Ono Mitsuaki、Ibaragi Soichiro、Yamamoto Tadashi、Suga Seiji、Takashiba Shogo
- Journal Title
  
  Journal of Fungi
  
  Volume: 9 Issue: 3 Pages: 314-314
- DOI
  10.3390/jof9030314
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K10108, KAKENHI-PROJECT-20K18509, KAKENHI-PROJECT-21K16992, KAKENHI-PROJECT-20K23054, KAKENHI-PROJECT-23K21486, KAKENHI-PROJECT-21K09842
[Journal Article] Complement Is Required for Microbe-Driven Induction of Th17 and Periodontitis2022
- Author(s)
  Wang Hui、Ideguchi Hidetaka、Kajikawa Tetsuhiro、Mastellos Dimitrios C.、Lambris John D.、Hajishengallis George
- Journal Title
  
  The Journal of Immunology
  
  Volume: 209 Issue: 7 Pages: 1370-1378
- DOI
  10.4049/jimmunol.2200338
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K17014, KAKENHI-PROJECT-20K23054
[Journal Article] Malnutrition delayed wound healing after tooth extraction by HMGB1-related prolonged inflammation2021
- Author(s)
  Yao Zhang, Hidetaka Ideguchi, Hiroaki Aoyagi, Keisuke Yamashiro, Tadashi Yamamoto, Masahiro Nishibori, Shogo Takashiba
- Journal Title
  
  Int Immunopharmacol
  
  Volume: 96 Pages: 107772-107772
- DOI
  10.1016/j.intimp.2021.107772
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K10128, KAKENHI-PROJECT-19H03408, KAKENHI-PROJECT-20K23054
[Journal Article] High Mobility Group Box 1 Expression in Oral Inflammation and Regeneration2020
- Author(s)
  Keisuke Yamashiro, Hidetaka Ideguchi, Hiroaki Aoyagi, Chiaki Yoshihara-Hirata, Anna Hirai, Risa Suzuki-Kyoshima, Yao Zhang, Hidenori Wake, Masahiro Nishibori, Tadashi Yamamoto, ShogoTakashiba
- Journal Title
  
  Frontiers in Immunology
  
  Volume: 11 Pages: 1461-1461
- DOI
  10.3389/fimmu.2020.01461
- NAID
  120006880201
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K10128, KAKENHI-PROJECT-20K23054
[Journal Article] Anti-HMGB1 Neutralizing Antibody Attenuates Periodontal Inflammation and Bone Resorption in a Murine Periodontitis Model2018
- Author(s)
  Yoshihara-Hirata Chiaki、Yamashiro Keisuke、Yamamoto Tadashi、Aoyagi Hiroaki、Ideguchi Hidetaka、Kawamura Mari、Suzuki Risa、Ono Mitsuaki、Wake Hidenori、Nishibori Masahiro、Takashiba Shogo
- Journal Title
  
  Infection and Immunity
  
  Volume: 86 Issue: 5
- DOI
  10.1128/iai.00111-18
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H06994, KAKENHI-PROJECT-16K20670, KAKENHI-PROJECT-18K17050, KAKENHI-PROJECT-16K11624
[Journal Article] HMGB1-induced inflammatory response promotes bone healing in murine tooth extraction socket2018
- Author(s)
  Aoyagi Hiroaki、Yamashiro Keisuke、Hirata-Yoshihara Chiaki、Ideguchi Hidetaka、Yamasaki Mutsuyo、Kawamura Mari、Yamamoto Tadashi、Kochi Shinsuke、Wake Hidenori、Nishibori Masahiro、Takashiba Shogo
- Journal Title
  
  Journal of Cellular Biochemistry
  
  Volume: - Issue: 7 Pages: 5481-5490
- DOI
  10.1002/jcb.26710
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H06994, KAKENHI-PROJECT-16K20670, KAKENHI-PROJECT-18K17050
[Journal Article] Modulation of microenvironment for controlling the fate of periodontal ligament cells: the role of Rho/ROCK signaling and cytoskeletal dynamics2017
- Author(s)
  Yamamoto Tadashi、Ugawa Yuki、Kawamura Mari、Yamashiro Keisuke、Kochi Shinsuke、Ideguchi Hidetaka、Takashiba Shogo
- Journal Title
  
  Journal of Cell Communication and Signaling
  
  Volume: 12 Issue: 1 Pages: 369-378
- DOI
  10.1007/s12079-017-0425-3
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H06994
[Journal Article] Aggregatibacter actinomycetemcomitans regulates the expression of integrins and reduces cell adhesion via integrin α5 in human gingival epithelial cells2017
- Author(s)
  Kochi Shinsuke、Yamashiro Keisuke、Hongo Shoichi、Yamamoto Tadashi、Ugawa Yuki、Shimoe Masayuki、Kawamura Mari、Hirata-Yoshihara Chiaki、Ideguchi Hidetaka、Maeda Hiroshi、Takashiba Shogo
- Journal Title
  
  Molecular and Cellular Biochemistry
  
  Volume: 436 Issue: 1-2 Pages: 39-48
- DOI
  10.1007/s11010-017-3076-z
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H06994
[Presentation] 侵襲性歯周炎の血液診断マーカー候補となる細胞外小胞由来マイクロRNAとその炎症誘導機構の探索2022
- Author(s)
  森彩乃，山本直史，井手口英隆，河村麻理，河本美奈，伊東昌洋，小野喜章，中山真彰，江口傑徳、大野充昭、大森一弘，高柴正悟．
- Organizer
  第65回春季日本歯周病学会学術大会
- Data Source
  KAKENHI-PROJECT-23K21486
[Presentation] 侵襲性歯周炎の血液診断マーカー候補となる細胞外小胞由来マイクロRNAとその炎症誘導機構．2021
- Author(s)
  森彩乃，山本直史，井手口英隆，河村麻理，河本美奈，伊東昌洋，小野喜章，中山真彰，山城圭介，大森一弘，高柴正悟．
- Organizer
  第42回日本炎症・再生医学会
- Data Source
  KAKENHI-PROJECT-23K21486
[Presentation] HMGB1はM1マクロファージへの分化を制御して歯周炎の進行に影響を及ぼす2021
- Author(s)
  平井杏奈，井手口英隆，山城圭介，Yao Zhang，青柳浩明，山本直史，高柴正悟
- Organizer
  第154回春季歯科保存学会学術大会
- Data Source
  KAKENHI-PROJECT-20K23054
[Presentation] High Mobility Group Box 1（HMGB1）はマクロファージからのCCL2分泌を制御して抜歯窩の歯周組織再生を促進する2020
- Author(s)
  井手口英隆，平井杏奈，山城圭介，京嶌里沙，青柳浩明，山本直史，高柴正悟
- Organizer
  第63回秋季日本歯周病学会学術大会
- Data Source
  KAKENHI-PROJECT-20K23054
[Presentation] HMGB1 Promotes Periodontitis by Regulating Macrophage to M1 Polarization2020
- Author(s)
  A. HIRAI, H. IDEGUCHI, K. YAMASHIRO, Z. YAO, C. YOSHIHARA-HIRATA, H. AOYAGI, T. YAMAMOTO, M. NISHIBORI ，S. TAKASHIBA
- Organizer
  第64回秋季日本歯周病学会学術大会
- Data Source
  KAKENHI-PROJECT-20K23054
[Presentation] 炎症性メディエーターHMGB1が歯槽骨治癒における血管新生の遺伝子発現を促進する2017
- Author(s)
  青柳浩明, 山城圭介, 井手口英隆, 平田千暁, 河村麻理, ,山崎睦代, 山本直史, 和氣秀徳, 西堀正洋, 高柴正悟
- Organizer
  日本炎症再生医学会
- Data Source
  KAKENHI-PROJECT-16H06994
[Presentation] 炎症性メディエーターHMGB1が歯槽骨治癒における血管新生の遺伝子発現を促進する2017
- Author(s)
  青柳浩明，山城圭介，吉原千暁，井手口英隆，山本直史，河村麻理，下江正幸，本郷昌一，劉克約，西堀正洋，高柴正悟
- Organizer
  第38回炎症再生医学会
- Data Source
  KAKENHI-PROJECT-16K20670
[Presentation] HMGB1が歯槽骨治癒に及ぼす影響2017
- Author(s)
  青柳浩明, 山城圭介, 井手口英隆, 平田千暁, 下江正幸, 河村麻理, 山本直史, 高柴正悟
- Organizer
  日本歯周病学会
- Data Source
  KAKENHI-PROJECT-16H06994
[Presentation] HMGB1が歯槽骨治癒に及ぼす影響2017
- Author(s)
  青柳浩明，山城圭介，吉原千暁，井手口英隆，山本直史，河村麻理，下江正幸，高柴正悟
- Organizer
  第60回日本歯周病学会
- Data Source
  KAKENHI-PROJECT-16K20670
[Presentation] 実験的歯周炎モデルマウスにおける抗HMGB1抗体の歯周炎抑制効果2016
- Author(s)
  吉原千暁，山城圭介，山本直史，井手口英隆，青柳浩明，下江正幸，本郷昌一，河村麻理，高柴正悟
- Organizer
  第59回春季日本歯周病学会
- Place of Presentation
  かごしま県民交流センター，鹿児島市
- Year and Date
  2016-05-21
- Data Source
  KAKENHI-PROJECT-16K20670
[Presentation] 炎症マーカーを標的とした分子イメージングによる歯周組織の新規検査法の確立に向けた臨床的／基礎的研究2016
- Author(s)
  井手口英隆、山城圭介、山本直史、下江正幸、高柴正悟
- Organizer
  第9回日本口腔検査学会学術大会
- Place of Presentation
  奥羽大学（福島県・郡山市）
- Year and Date
  2016-10-01
- Data Source
  KAKENHI-PROJECT-16H06994
[Presentation] Anti-HMGB1 neutralizing antibody attenuates cytokine secretion and progression of periodontitis2016
- Author(s)
  C. YOSHIHARA，K. YAMASHIRO，T. YAMAMOTO，H. IDEGUCHI，H. AOYAGI，M. SHIMOE，S. HONGO，M. KAWAMURA，K. Liu，M. NISHIBORI，S. TAKASHIBA，
- Organizer
  IADR/APR General Session & Exhibition
- Place of Presentation
  COEX Convention Center, Korea, Seoul
- Year and Date
  2016-06-22
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K20670

1. YAMAMOTO Tadashi (50432662)

# of Collaborated Projects: 3 results

# of Collaborated Products: 6 results
2. TAKASHIBA Shogo (50226768)

# of Collaborated Projects: 2 results

# of Collaborated Products: 7 results
3. YAMASHIRO KEISUKE (30581087)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
4. AOYAGI Hiroaki (10814501)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
5. KOCHI Shinsuke (70803138)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. WAKE Hidenori (60570520)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. NISHIBORI Masahiro (50135943)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
8. 江口傑徳 (20457229)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
9. 宮地孝明 (40550314)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 江國大輔 (70346443)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 伊東有希 (80771162)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 伊東孝 (30636238)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. OMORI Kazuhiro

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. MANDAI Hiroki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. NAKAYAMA Masaaki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Ideguchi Hidetaka 井手口 英隆

Research Projects

Research Products

Co-Researchers

永久歯の感染性歯髄炎への抗炎症物質RvD2応用によるVital Pulp Therapy有効性の検討

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Periodontal pathology derived from crosstalk between complement and Th17 cells and novel treatment conceptsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

細胞外小胞の口腔トロピズムを基軸とする侵襲性歯周炎の病態解明と診断への応用展開

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Immunological Effects of HMGB1 on Periodontal Disease and Novel Periodontal Disease Treatment by HMGB1 RegulationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Control of periodontal inflammation by anti-inflammatory molecular targeting drug applied with nano drug delivery systemPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Functional analysis of HMGB1 as an inflammatory mediator in periodontitis

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Ligneous periodontitis exacerbated by Beh?et’s disease in a patient with plasminogen deficiency and a stop-gained variant PLG c.1468C?&gt;?T: a case report2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The Fungal Metabolite (+)-Terrein Abrogates Inflammatory Bone Resorption via the Suppression of TNF-α Production in a Ligature-Induced Periodontitis Mouse Model2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Complement Is Required for Microbe-Driven Induction of Th17 and Periodontitis2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Malnutrition delayed wound healing after tooth extraction by HMGB1-related prolonged inflammation2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] High Mobility Group Box 1 Expression in Oral Inflammation and Regeneration2020

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Anti-HMGB1 Neutralizing Antibody Attenuates Periodontal Inflammation and Bone Resorption in a Murine Periodontitis Model2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] HMGB1-induced inflammatory response promotes bone healing in murine tooth extraction socket2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Modulation of microenvironment for controlling the fate of periodontal ligament cells: the role of Rho/ROCK signaling and cytoskeletal dynamics2017

Author(s)

Journal Title

DOI

Ideguchi Hidetaka 井手口英隆

[Journal Article] Ligneous periodontitis exacerbated by Beh?et’s disease in a patient with plasminogen deficiency and a stop-gained variant PLG c.1468C?>?T: a case report2023

[Presentation] High Mobility Group Box 1（HMGB1）はマクロファージからのCCL2分泌を制御して抜歯窩の歯周組織再生を促進する2020

[Presentation] 炎症性メディエーターHMGB1が歯槽骨治癒における血管新生の遺伝子発現を促進する2017