Yamamoto Seigi 山本清義

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YAMAMOTO Seigi 山本清義

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Researcher Number	80783521
Affiliation (Current)	2025: 千葉県がんセンター(研究所), がんゲノムセンター進化腫瘍学研究室, 研究員
Affiliation (based on the past Project Information) *help	2019 – 2022: 千葉県がんセンター(研究所), がん治療開発グループがん遺伝創薬研究室, 研究員 2018: 徳島大学, 大学院医歯薬学研究部(薬学域), 特任助教 2016 – 2017: 徳島大学, 大学院医歯薬学研究部(薬学系), 特任助教
Review Section/Research Field	Principal Investigator Basic Section 37030:Chemical biology-related / Basic Section 28040:Nanobioscience-related / Nanobioscience Except Principal Investigator Basic Section 50020:Tumor diagnostics and therapeutics-related / Basic Section 37030:Chemical biology-related
Keywords	Principal Investigator ドラッグデリバリー / 核酸創薬 / 核酸ナノテクノロジー / 経皮吸収薬 / がん治療薬 / PIポリアミド / ミトコンドリア / 皮膚透過 / ミトコンドリア標的化合物 / DNA副溝結合化合物 … More / ミトコンドリア標的薬 / ミトコンドリアDNA / PIP / ピロールイミダゾールポリアミド / 細胞内送達 / ナノ構造体 / DNA / 核酸 / 原子間力顕微鏡 / DNAナノテクノロジー / ドラッグデリバリーシステム / 核酸医薬 / 核酸化学 … More Except Principal Investigator エピゲノム / 遺伝子変異 / 創薬開発 / がん / 分子標的化合物 / ゲノム変異 / マイナーグルーブバインダー / ミトコンドリア / 腫瘍特異性 / 効果副作用予測 / 分子標的治療 / ゲノム創薬 / DNA副溝結合化合物 / RNAi医薬品 / 微弱電流 / 核酸ナノ構造体 / iRed / RNAi医薬 / 核酸創薬 Less

Development of skin-permeable cancer therapeutics targeting mitochondria DNAPrincipal Investigator
- Principal Investigator
  
  Yamamoto Seigi
- Project Period (FY)
  2021 – 2022
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 37030:Chemical biology-related
- Research Institution
  Chiba Cancer Center (Research Institute)
Development of anticancer drugs targeting the mutated cancer genome
- Principal Investigator
  
  永瀬浩喜
- Project Period (FY)
  2020 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Chiba Cancer Center (Research Institute)
The development of D-NANs for elucidation of intracellular translocation mechanism of nucleic acid nanostructuresPrincipal Investigator
- Principal Investigator
  
  Seigi Yamamoto
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 28040:Nanobioscience-related
- Research Institution
  Chiba Cancer Center (Research Institute)
  The University of Tokushima
Development of photoresponsive DNA nanostructure to accerelate iRed based nucleic acid medicine
- Principal Investigator
  
  MINAKAWA Noriaki
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 37030:Chemical biology-related
- Research Institution
  The University of Tokushima
Development of Football integrated Nucleic Acid Medicine Delivery system: FiNADsPrincipal Investigator
- Principal Investigator
  
  YAMAMOTO Seigi
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Nanobioscience
- Research Institution
  The University of Tokushima

All 2022 2021 2020 2018 2017

All Journal Article Presentation

[Journal Article] Suppression of NSCLC A549 tumor growth by a mtDNA mutation‐targeting pyrrole‐imidazole polyamide‐TPP and a senolytic drug2022
- Author(s)
  Tsuji Kohei、Kida Yuki、Koshikawa Nobuko、Yamamoto Seigi、Shinozaki Yoshinao、Watanabe Takayoshi、Lin Jason、Nagase Hiroki、Takenaga Keizo
- Journal Title
  
  Cancer Science
  
  Volume: - Issue: 4 Pages: 1321-1337
- DOI
  10.1111/cas.15290
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H03540, KAKENHI-PROJECT-19K07408, KAKENHI-PROJECT-20K07710, KAKENHI-PROJECT-19K07654, KAKENHI-PROJECT-22H04923
[Journal Article] Anticancer effect of a pyrrole‐imidazole polyamide‐triphenylphosphonium conjugate selectively targeting a common mitochondrial DNA cancer risk variant in cervical cancer cells2022
- Author(s)
  Yao Jihang、Takenaga Keizo、Koshikawa Nobuko、Kida Yuki、Lin Jason、Watanabe Takayoshi、Maru Yoshiaki、Hippo Yoshitaka、Yamamoto Seigi、Zhu Yuyan、Nagase Hiroki
- Journal Title
  
  International Journal of Cancer
  
  Volume: 152 Issue: 5 Pages: 962-976
- DOI
  10.1002/ijc.34319
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K08019, KAKENHI-PROJECT-21K09506, KAKENHI-PROJECT-19K07408, KAKENHI-PROJECT-19K07654, KAKENHI-PROJECT-20K07710, KAKENHI-PROJECT-21K14756, KAKENHI-PROJECT-22H04923
[Journal Article] Mitochondria: Endosymbiont bacteria DNA sequence as a target against cancer2021
- Author(s)
  Nagase Hiroki、Watanabe Takayoshi、Koshikawa Nobuko、Yamamoto Seigi、Takenaga Keizo、Lin Jason
- Journal Title
  
  Cancer Science
  
  Volume: 112 Issue: 12 Pages: 4834-4843
- DOI
  10.1111/cas.15143
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H03540, KAKENHI-PROJECT-19K07408, KAKENHI-PROJECT-19K07654, KAKENHI-PROJECT-20K07710
[Journal Article] A linear five-ring pyrrole-imidazole polyamide-triphenylphosphonium conjugate targeting a mitochondrial DNA mutation efficiently induces apoptosis of HeLa cybrid cells carrying the mutation2021
- Author(s)
  Koshikawa Nobuko、Kida Yuki、Yasui Nanami、Shinozaki Yoshinao、Tsuji Kohei、Watanabe Takayoshi、Lin Jason、Yamamoto Seigi、Takenaga Keizo、Nagase Hiroki
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 576 Pages: 93-99
- DOI
  10.1016/j.bbrc.2021.08.088
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H03540, KAKENHI-PROJECT-19K07408, KAKENHI-PROJECT-20K07710
[Presentation] 変異mtDNA標的PIP-TPPとBcl-xL阻害剤の併用による非小細胞肺癌A549腫瘍のSenotherapy2021
- Author(s)
  山本　清義、辻　航平、越川　信子、木田　裕貴、渡部隆義、リンジェイソン、竹永啓三、永瀬浩喜
- Organizer
  第80回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-20H03540
[Presentation] 機械学習を用いた配列特異的ピロールイミダゾールポリアミド・ボリノスタット複合体によるがんゲノム結合の評価2021
- Author(s)
  リンジェイソン、細矢　和、佐久間　誠、木田　裕貴、渡部　隆義、山本　清義、高取　敦志、越川　信子、永瀬　浩喜
- Organizer
  第80回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-20H03540
[Presentation] ミトコンドリアDNA変異を標的にした薬剤候補によるがん細胞老化、細胞死、老化細胞除去誘導2020
- Author(s)
  永瀬浩喜、越川信子、山本清義、辻航平、木田裕貴、竹永敬三
- Organizer
  第79回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-20H03540
[Presentation] 機械学習によるSAHA化ピロールイミダゾールポリアミドで特異な遺伝子クラスター活性化現象の評価2020
- Author(s)
  Jason Lin、佐久間誠、木田裕貴、渡部隆義、山本清義、高取敦志、越川信子、永瀬浩喜
- Organizer
  第79回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-20H03540
[Presentation] 機械学習に基づくPIポリアミドの抗がん剤としての副作用予測モデルの開発2020
- Author(s)
  佐久間誠、リンジェイソン、高取敦志、渡部隆義、山本清義、越川信子、木田裕貴、永瀬浩喜
- Organizer
  第79回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-20H03540
[Presentation] Development of nucleic acid medicine delivery system using photo responsive nucleic acid nanostructure2018
- Author(s)
  山本　清義
- Organizer
  日本化学会　第９８春季年会
- Data Source
  KAKENHI-PROJECT-16H07012
[Presentation] Development and Evaluation of Photoresponsive DNA Prism with Nucleic Acid Medicine2018
- Author(s)
  山本　清義
- Organizer
  第45回国際核酸化学シンポジウム
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K14097
[Presentation] Development and Evaluation of Photoresponsive DNA Prism with Nucleic Acid Medicine2018
- Author(s)
  Seigi Yamamoto, Noriko Saito-Tarashima, Naoshi Yamazaki, Tatsuya Fukuta, Kentaro Kogure, Noriaki Minakawa
- Organizer
  The 45th International Symposium on Nucleic Acids Chemistry (ISNAC 2018）
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02108
[Presentation] Development of Photoresponsive DNA Nanostructure Integrated Nucleic Acid Medicine2017
- Author(s)
  山本　清義
- Organizer
  第44回国際核酸化学シンポジウム
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H07012
[Presentation] 核酸医薬分子を組み込んだDNAナノ構造体の構築とその性質2017
- Author(s)
  山本　清義
- Organizer
  日本核酸医薬学会第三回年会
- Data Source
  KAKENHI-PROJECT-16H07012

1. MINAKAWA Noriaki (40209820)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
2. 小暮健太朗 (70262540)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
3. 田良島典子 (90755183)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
4. 永瀬浩喜 (90322073)

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
5. LIN JASON (80774124)

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
6. 筆宝義隆

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 丸喜明

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Yamamoto Seigi 山本 清義

YAMAMOTO Seigi 山本 清義

Research Projects

Research Products

Co-Researchers

Development of skin-permeable cancer therapeutics targeting mitochondria DNAPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of anticancer drugs targeting the mutated cancer genome

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The development of D-NANs for elucidation of intracellular translocation mechanism of nucleic acid nanostructuresPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of photoresponsive DNA nanostructure to accerelate iRed based nucleic acid medicine

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of Football integrated Nucleic Acid Medicine Delivery system: FiNADsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Suppression of NSCLC A549 tumor growth by a mtDNA mutation‐targeting pyrrole‐imidazole polyamide‐TPP and a senolytic drug2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Anticancer effect of a pyrrole‐imidazole polyamide‐triphenylphosphonium conjugate selectively targeting a common mitochondrial DNA cancer risk variant in cervical cancer cells2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Mitochondria: Endosymbiont bacteria DNA sequence as a target against cancer2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A linear five-ring pyrrole-imidazole polyamide-triphenylphosphonium conjugate targeting a mitochondrial DNA mutation efficiently induces apoptosis of HeLa cybrid cells carrying the mutation2021

Author(s)

Journal Title

DOI

Data Source

[Presentation] 変異mtDNA標的PIP-TPPとBcl-xL阻害剤の併用による非小細胞肺癌A549腫瘍のSenotherapy2021

Author(s)

Organizer

Data Source

[Presentation] 機械学習を用いた配列特異的ピロールイミダゾールポリアミド・ボリノスタット複合体によるがんゲノム結合の評価2021

Author(s)

Organizer

Data Source

[Presentation] ミトコンドリアDNA変異を標的にした薬剤候補によるがん細胞老化、細胞死、老化細胞除去誘導2020

Author(s)

Organizer

Data Source

[Presentation] 機械学習によるSAHA化ピロールイミダゾールポリアミドで特異な遺伝子クラスター活性化現象の評価2020

Author(s)

Organizer

Data Source

[Presentation] 機械学習に基づくPIポリアミドの抗がん剤としての副作用予測モデルの開発2020

Author(s)

Organizer

Data Source

[Presentation] Development of nucleic acid medicine delivery system using photo responsive nucleic acid nanostructure2018

Author(s)

Organizer

Data Source

[Presentation] Development and Evaluation of Photoresponsive DNA Prism with Nucleic Acid Medicine2018

Yamamoto Seigi 山本清義

YAMAMOTO Seigi 山本清義