Ito Tatsuo 伊藤達男

Researcher Number	80789123
Other IDs
Affiliation (Current)	2025: 川崎医科大学, 医学部, 教授 2025: 川崎医療福祉大学, 医療福祉マネジメント学部, 教授
Affiliation (based on the past Project Information) *help	2021 – 2024: 川崎医科大学, 医学部, 教授 2019 – 2020: 川崎医科大学, 医学部, 講師 2017 – 2020: 岡山大学, 医歯薬学総合研究科, 助教
Review Section/Research Field	Principal Investigator Basic Section 58020:Hygiene and public health-related: including laboratory approach / Basic Section 50020:Tumor diagnostics and therapeutics-related / Hygiene and public health Except Principal Investigator Basic Section 58020:Hygiene and public health-related: including laboratory approach / Basic Section 55020:Digestive surgery-related / Basic Section 54010:Hematology and medical oncology-related / Basic Section 54020:Connective tissue disease and allergy-related / Basic Section 57020:Oral pathobiological science-related / Basic Section 56020:Orthopedics-related / Medium-sized Section 58:Society medicine, nursing, and related fields / Hygiene and public health
Keywords	Principal Investigator RNA編集 / 老化 / CRISPR/dCas13 / サルコペニア / lncRNA / 滑膜肉腫 / がん抗原SSX / クロマチン制御 / 肝細胞癌 / x染色体不活性化 … More / 融合遺伝子 / 分子標的薬 / X染色体転座 / 悪性軟部肉腫 / BET抑制剤 / 社会医学 / in vivo発がん試験 / DNA二重鎖切断修復 / 染色体遺伝子不安定性 / CRISPR/Cas9 / DNA-PKcs / NHEJ / BAP1 / 悪性中皮腫 … More Except Principal Investigator SOD2 / PM2.5 / mRNA創薬 / RNA解析 / CRISPR/Cas13 / 人工知能 / 膵癌 / CRISPR/Cas / 遺伝子治療 / 遺伝子異常 / 造血器腫瘍 / 成人T細胞白血病 / RNA編集 / VEXAS症候群 / 自己炎症性疾患 / CRISPR/dCas13 / 治療 / スクリーニング / がん / エピジェネティクスの制御 / 制御性T細胞（Treg） / 自己免疫疾患 / long non-coding RNA / 制御性T細胞 / シェーグレン症候群 / 複合がん免疫療法 / 悪性軟部腫瘍 / シグナル伝達 / 増殖抑制 / PRRX1 / 増殖 / 肺転移 / 悪性骨・軟部腫瘍 / PRX1 / 浸潤 / 転移 / 骨肉腫 / 磁性 / ナノＰＭ / 自己抗体 / エンドサイトーシス / ニトロチロシン / ナノPM / 新型コロナウイルス / clathrin / 大気環境 / 好酸球炎症 / チロシンニトロ化 / ヒトアルブミン / 運動トレーニング評価法 / 硫化水素代謝酵素 / mRNA / 末梢血 / ミトコンドリア / 抗酸化酵素 / 運動トレーニング評価 / ミトホルミシス / 抗酸化酵素mRNA / 末梢血単核球 / 喘息発症機序 / 蛋白質 / TSLP / サイクロンPM2.5 / 重金属 / 大気汚染物質 / PM蛋白２ / PM蛋白１ / transboundary factor / PM protein 2 / PM protein1 Less

成人自己炎症性疾患VEXAS症候群の病態解明およびCas13を用いた革新的遺伝子治療の開発
- Principal Investigator
  
  向井知之
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 54020:Connective tissue disease and allergy-related
- Research Institution
  Kawasaki Medical School
成人T細胞白血病に対するCRISPR-Cas13を用いた遺伝子治療戦略の開発
- Principal Investigator
  
  坂本祐真
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Kawasaki Medical School
AIとイメージングでEMT型膵癌の機能を定量化しCRISPRで機能的RNAを狙う新規治療の探索
- Principal Investigator
  
  矢野修也
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Kawasaki Medical School
The lncRNA landscape of skeletal muscle cell biotransformation with aging.Principal Investigator
- Principal Investigator
  
  伊藤達男
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 58020:Hygiene and public health-related: including laboratory approach
- Research Institution
  Kawasaki Medical School
制御性T細胞の変化が関わるシェーグレン症候群特異的な新規非翻訳RNAの探索と解析
- Principal Investigator
  
  池田淳史
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57020:Oral pathobiological science-related
- Research Institution
  Okayama University
CRISPR/dCas13システムを用いた革新的がん治療戦略の構築
- Principal Investigator
  
  武井直子
- Project Period (FY)
  2022 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 58020:Hygiene and public health-related: including laboratory approach
- Research Institution
  Kawasaki Medical School
Development of irregular X-chromosome inactivation-specific targeted therapyPrincipal Investigator
- Principal Investigator
  
  Ito Tatsuo
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Kawasaki Medical School
Development of new combined cancer immunotherapy for malignant soft tissue tumor
- Principal Investigator
  
  Nakata Eiji
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  Okayama University
Development of a New Evaluation Method for Exercise Training Using Mitochondrial Activation of Peripheral Blood Mononuclear Cells
- Principal Investigator
  
  Ogino Keiki
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 58:Society medicine, nursing, and related fields
- Research Institution
  Kochi University
  Okayama University
Biological effect and preventive method for human serum albumin binding to transboundary air borne PM2.5.
- Principal Investigator
  
  Ogino Keiki
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 58020:Hygiene and public health-related: including laboratory approach
- Research Institution
  Kochi University
  Okayama University
Practical Application of Cancer Suppressor BAP1 Activity as a Biomarker for Malignant MesotheliomaPrincipal Investigator
- Principal Investigator
  
  Ito Tatsuo
- Project Period (FY)
  2017 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hygiene and public health
- Research Institution
  Kawasaki Medical School
  Okayama University
PM protein 1 may be one of transboundary environmental factor.
- Principal Investigator
  
  ogino keiki
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Hygiene and public health
- Research Institution
  Okayama University

All 2021 2020 2019 2018 2017 2016

All Journal Article Presentation Patent

[Journal Article] <i>SOD2</i> mRNA as a potential biomarker for exercise: interventional and cross-sectional research in healthy subjects2021
- Author(s)
  Shihona Ogino, Noriyoshi Ogino, Kotomi Tomizuka, Masamitsu Eitoku, Yosuke Okada, Yoshiya Tanaka, Narufumi Suganuma, and Keiki Ogino
- Journal Title
  
  Journal of Clinical Biochemistry and Nutrition
  
  Volume: 69 Issue: 2 Pages: 137-144
- DOI
  10.3164/jcbn.21-24
- NAID
  130008035997
- ISSN
  0912-0009, 1880-5086
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K19681, KAKENHI-PROJECT-19K21427
[Journal Article] The identification of tyrosine-nitrated human serum albumin in airborne particulate matter from Japan2021
- Author(s)
  Ogino Noriyoshi、Ogino Keiki、Eitoku Masamitsu、Suganuma Narufumi、Nagaoka Kenjiro、Kuramitsu Yasuhiro
- Journal Title
  
  Atmospheric Pollution Research
  
  Volume: 12 Issue: 5 Pages: 101050-101050
- DOI
  10.1016/j.apr.2021.03.013
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H03039
[Journal Article] Enhanced expression of nicotinamide nucleotide transhydrogenase (NNT) and its role in a human T cell line continuously exposed to asbestos2020
- Author(s)
  Yamamoto Shoko、Lee Suni、Matsuzaki Hidenori、Kumagai-Takei Naoko、Yoshitome Kei、Sada Nagisa、Shimizu Yurika、Ito Tastsuo、Nishimura Yasumitsu、Otsuki Takemi
- Journal Title
  
  Environment International
  
  Volume: 138 Pages: 105654-105654
- DOI
  10.1016/j.envint.2020.105654
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09157, KAKENHI-PROJECT-19H03892
[Journal Article] Detection of 3-Nitrotyrosine in Atmospheric Environments via a Highperformance Liquid Chromatography-electrochemical Detector System2019
- Author(s)
  Ito T, Ogino K, Nagaoka K, Takemoto K, Nishiyama R, Shimizu Y
- Journal Title
  
  JoVE
  
  Volume: 143 Issue: 143
- DOI
  10.3791/58371
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H03039, KAKENHI-PROJECT-18K17354
[Journal Article] Human albumin augmented airway inflammation induced by PM2.5 in NC/Nga mice.2019
- Author(s)
  Nagaoka K, Ogino K, Ogino N, Ito T, Takemoto K, Ogino S, Seki Y, Hamada H, Fujikura Y.
- Journal Title
  
  Environ Toxicol
  
  Volume: accepted.
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18H03039
[Journal Article] Human albumin augmented airway inflammation induced by PM2.5 in NC/Nga mice2019
- Author(s)
  Nagaoka Kenjiro、Ogino Keiki、Ogino Noriyoshi、Ito Tatsuo、Takemoto Kei、Ogino Shihona、Seki Yuka、Hamada Hiroki、Fujikura Yoshihisa
- Journal Title
  
  Environmental Toxicology
  
  Volume: 34 Issue: 7 Pages: 836-843
- DOI
  10.1002/tox.22751
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K15977, KAKENHI-PROJECT-18K17354, KAKENHI-PROJECT-18H03039
[Journal Article] Head cooling during sleep improves sleep quality in the luteal phase in female university students: A randomized crossover-controlled pilot study.2019
- Author(s)
  Hamanishi S, Eguchi E, Ito T, Nagaoka K, Ogino K.
- Journal Title
  
  PLoS One.
  
  Volume: 14 Issue: 3 Pages: e0213706-e0213706
- DOI
  10.1371/journal.pone.0213706
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K19681
[Journal Article] Involvement of PM2.5-bound protein and metals in PM2.5-induced allergic airway inflammation in mice.2018
- Author(s)
  Ogino K, Nagaoka K, Ito T, Takemoto K, Okuda T, Nakayama SF, Ogino N, Seki Y, Hamada H, Takashiba S, Fujikura Y.
- Journal Title
  
  Inhal Toxicol.
  
  Volume: 30 Issue: 13-14 Pages: 498-508
- DOI
  10.1080/08958378.2018.1561769
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K15977, KAKENHI-PROJECT-18H03039
[Journal Article] Relationship of particulate matter and ozone with 3-nitrotyrosine in the atmosphere.2018
- Author(s)
  Ito T, Ogino K, Nagaoka K, Takemoto K
- Journal Title
  
  Environ Pollut.
  
  Volume: 236C Pages: 948-952
- DOI
  10.1016/j.envpol.2017.10.069
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K15373, KAKENHI-PROJECT-18H03039
[Journal Article] Early obesity leads to increases in hepatic arginase I and related systemic changes in nitric oxide and L-arginine metabolism in mice.2018
- Author(s)
  Ito T, Kubo M, Nagaoka K, Funakubo N, Setiawan H, Takemoto K, Eguchi E, Fujikura Y, Ogino K
- Journal Title
  
  J Physiol Biochem.
  
  Volume: 74 Issue: 1 Pages: 9-16
- DOI
  10.1007/s13105-017-0597-6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K19681
[Journal Article] Human lactoferrin induces asthmatic symptoms in NC/Nga mice.2017
- Author(s)
  Nagaoka K, Ito T, Ogino K, Eguchi E, Fujikura Y
- Journal Title
  
  Physiol Rep
  
  Volume: 5 Issue: 15 Pages: e13365-e13365
- DOI
  10.14814/phy2.13365
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K15373
[Patent] 刺激により活性化し、高精度で標的RNA を検出/分離/精製できるPA-dCas13 システム2021
- Inventor(s)
  伊藤達男
- Industrial Property Rights Holder
  川崎医科大学
- Industrial Property Rights Type
  特許
- Filing Date
  2021
- Data Source
  KAKENHI-PROJECT-17K09157
[Presentation] BETは滑膜肉腫特異的発現融合タンパク質SS18-SSXと相互作用を行う分子標的である2020
- Author(s)
  伊藤達男
- Organizer
  第53回日本整形外科学会骨・軟部腫瘍学術集会
- Data Source
  KAKENHI-PROJECT-20K07687
[Presentation] PM2.5 曝露による気道上皮細胞の粘液発現.2019
- Author(s)
  長岡憲次郎、荻野学芳、竹本圭、伊藤達男、笹岡香織、荻野景規
- Organizer
  第89回日本衛生学会学術総会
- Data Source
  KAKENHI-PROJECT-18H03039
[Presentation] アルギナーゼI上昇は、L-arginineを消費し、NO産生を抑制し、糖尿病の発症に関連する .2019
- Author(s)
  荻野景規、長岡憲次郎、荻野学芳、松浦有希、伊藤達男
- Organizer
  日本薬学会第139年会
- Data Source
  KAKENHI-PROJECT-18K19681
[Presentation] PM2.5のタンパク質を介した生体影響2019
- Author(s)
  荻野景規、長岡憲次郎、伊藤達男、松浦有希
- Organizer
  第26回クロマトグラフィーシンボジウム
- Data Source
  KAKENHI-PROJECT-18H03039
[Presentation] 睡眠時の頭部冷却が月経前の睡眠脳波に及ぼす影響2018
- Author(s)
  濱西誠司、伊藤達男、長岡憲次郎、江口依里、荻野景規
- Organizer
  第16回日本予防医学会学術総会
- Data Source
  KAKENHI-PROJECT-18K19681
[Presentation] 気道上皮細胞におけるPM2.5 曝露に対する粘液産生の影響.2018
- Author(s)
  長岡憲次郎、伊藤達男、竹本圭、江口依里、荻野景規
- Organizer
  第88回日本衛生学会学術総会
- Data Source
  KAKENHI-PROJECT-16K15373
[Presentation] 睡眠時の頭部冷却が月経前の睡眠の質に及ぼす影響2018
- Author(s)
  濱西誠司、伊藤達男、長岡憲次郎、江口依里、荻野景規
- Organizer
  第88回日本衛生学会学術総会
- Data Source
  KAKENHI-PROJECT-18K19681
[Presentation] 大気中PM タンパク質の3- ニトロチロシン生成と大気汚染物質の関連性.2018
- Author(s)
  伊藤達男、長岡憲次郎、竹本圭、荻野景規
- Organizer
  第88回日本衛生学会学術総会
- Data Source
  KAKENHI-PROJECT-16K15373
[Presentation] 労働者における動脈硬化とアルギナーゼ1およびN0関連因子の関連性について2018
- Author(s)
  長岡憲次郎、荻野学芳、笹岡香織、伊藤達男、荻野景規
- Organizer
  第62回中国四国合同産業衛生学会
- Data Source
  KAKENHI-PROJECT-18K19681
[Presentation] 化学ストレス環境下における細胞内でのアルギニンメチル化基質の役割2018
- Author(s)
  伊藤達男、荻野景規、長岡憲次郎、竹本圭
- Organizer
  第91回日本産業衛生学会
- Data Source
  KAKENHI-PROJECT-18K19681
[Presentation] PM2.5の培養細胞における毒性学的評価2018
- Author(s)
  長岡憲次郎、伊藤達男、竹本圭、江口依里、荻野景規
- Organizer
  第16回日本予防医学会学術総会
- Data Source
  KAKENHI-PROJECT-18H03039
[Presentation] 大気中PM タンパク質の3- ニトロチロシン生成と大気汚染物質の関連性.2018
- Author(s)
  伊藤達男、長岡憲次郎、竹本圭、荻野景規
- Organizer
  第88回日本衛生学会学術総会
- Data Source
  KAKENHI-PROJECT-18H03039
[Presentation] 浮遊粒子状物質とニトロ化タンパクの共曝露によるマウス気道炎症の発症.2018
- Author(s)
  竹本圭、長岡憲次郎、伊藤達男、荻野景規
- Organizer
  第88回日本衛生学会学術総会
- Data Source
  KAKENHI-PROJECT-16K15373
[Presentation] 気道上皮細胞におけるPM2.5 曝露に対する粘液産生の影響2018
- Author(s)
  長岡憲次郎、伊藤達男、竹本圭、江口依里、荻野景規
- Organizer
  第88回日本衛生学会学術総会
- Data Source
  KAKENHI-PROJECT-18H03039
[Presentation] 浮遊粒子状物質とニトロ化タンパクの共曝露によるマウス気道炎症の発症.2018
- Author(s)
  竹本圭、長岡憲次郎、伊藤達男、荻野景規
- Organizer
  第88回日本衛生学会学術総会
- Data Source
  KAKENHI-PROJECT-18H03039
[Presentation] 労働者のメンタルヘルスと血清アルギナーゼ活性は関連するか2018
- Author(s)
  荻野学芳、荻野志穂奈、長岡憲次郎、伊藤達男、荻野景規
- Organizer
  第62回中国四国合同産業衛生学会
- Data Source
  KAKENHI-PROJECT-18K19681
[Presentation] 本邦初のPM2.5による喘息実験の成功とそのメカニズム-PM2.5組成との関連性.2017
- Author(s)
  長岡憲次郎, 荻野景規, 伊藤達男
- Organizer
  第87回日本衛生学会学術集会シンポジウム6
- Place of Presentation
  フェニックス・シーガイア・リゾート(宮崎市）
- Year and Date
  2017-03-27
- Data Source
  KAKENHI-PROJECT-16K15373
[Presentation] 本邦初のPM2.5による喘息実験の成功とそのメカニズム-PM2.5組成との関連性.2017
- Author(s)
  長岡憲次郎、荻野景規、伊藤達男
- Organizer
  第87回日本衛生学会学術集会
- Data Source
  KAKENHI-PROJECT-16K15373
[Presentation] タンパク質によるPM2.5のアレルギー性気道炎症の増強作用.2017
- Author(s)
  荻野景規、伊藤達男、長岡憲次郎、江口依里、竹本圭、藤倉義久
- Organizer
  第58回大気環境学会年会
- Data Source
  KAKENHI-PROJECT-16K15373
[Presentation] PM2.5による喘息の発症～組成による発生機序～.2016
- Author(s)
  荻野景規, 長岡憲次郎, 伊藤達男
- Organizer
  第86回日本衛生学会学術総会シンポジウム
- Place of Presentation
  旭川市民文化会館(北海道　旭川市）
- Year and Date
  2016-05-12
- Data Source
  KAKENHI-PROJECT-16K15373

1. ogino keiki (70204104)

# of Collaborated Projects: 4 results

# of Collaborated Products: 26 results
2. 長岡憲次郎 (40752374)

# of Collaborated Projects: 4 results

# of Collaborated Products: 26 results
3. 江口依里 (60635118)

# of Collaborated Projects: 3 results

# of Collaborated Products: 5 results
4. 高柴正悟 (50226768)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
5. 清水由梨香 (80963355)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
6. Nakata Eiji (10649304)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. 大内田守 (80213635)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. 荻野学芳 (70614204)

# of Collaborated Projects: 2 results

# of Collaborated Products: 19 results
9. 荻野志穂奈 (70746685)

# of Collaborated Projects: 2 results

# of Collaborated Products: 17 results
10. 浜田博喜 (10164914)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
11. 菅沼成文 (50313747)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
12. 栄徳勝光 (50552733)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
13. 宝田剛志 (30377428)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
14. 武井直子 (00509276)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
15. 向井知之 (00454421)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
16. 坂本祐真 (90865817)

# of Collaborated Projects: 2 results

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17. 古松毅之 (20432651)

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Ito Tatsuo 伊藤 達男

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The lncRNA landscape of skeletal muscle cell biotransformation with aging.Principal Investigator

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Development of irregular X-chromosome inactivation-specific targeted therapyPrincipal Investigator

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Practical Application of Cancer Suppressor BAP1 Activity as a Biomarker for Malignant MesotheliomaPrincipal Investigator

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[Journal Article] <i>SOD2</i> mRNA as a potential biomarker for exercise: interventional and cross-sectional research in healthy subjects2021

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[Journal Article] The identification of tyrosine-nitrated human serum albumin in airborne particulate matter from Japan2021

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Ito Tatsuo 伊藤達男