Iguchi Yohei 井口洋平

… Alternative Names

IGUCHI YOHEI 井口洋平

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Researcher Number	80790659
Other IDs	https://orcid.org/0000-0001-7434-9801
Affiliation (Current)	2024: 名古屋大学, 医学部附属病院, 講師
Affiliation (based on the past Project Information) *help	2023 – 2024: 名古屋大学, 医学部附属病院, 講師 2018 – 2023: 名古屋大学, 医学部附属病院, 助教 2017: 名古屋大学, 医学部附属病院, 医員
Review Section/Research Field	Principal Investigator Medium-sized Section 52:General internal medicine and related fields / Basic Section 52020:Neurology-related / Neurology Except Principal Investigator Medium-sized Section 52:General internal medicine and related fields / Basic Section 52020:Neurology-related / Basic Section 51030:Pathophysiologic neuroscience-related / Neurology
Keywords	Principal Investigator 筋萎縮性側索硬化症 / TDP-43 / ALS / オリゴデンドロサイト / FTLD / 運動ニューロン / TDP-43ノックインマウス / TDP-43凝集阻害 / コリントランスポーター / 声帯麻痺 … More / ノックインマウス / SLC5A7 / 遠位型遺伝性運動ニューロパチー / タンパク伝播 / TDP-43伝播 / オリゴデンデロサイト / 凝集タンパク伝播 / TDP-43伝搬 / 異常タンパク凝集 / ニューロン / 凝集タンパク質の細胞間伝播 / prion-like propagation / protein aggregation / polysome解析 / 前頭側頭葉変性症 / TBK1 … More Except Principal Investigator 神経変性疾患 / 運動ニューロン / 運動ニューロン疾患 / シナプス / シヌクレイン / 神経変性 / 核酸 / アンチセンス核酸 / 胎児 / 転写障害 / 早期病態 / 球脊髄性筋萎縮症 / 神経活動 / TDP-43 / タンパク質凝集体 / ポリグルタミン / タンパク質凝集 / 凝集タンパク質 / 低分子干渉RNA / イオンチャンネル / シングルセル解析 / マルチモーダル解析 / オリゴデンドロサイト / FUS / CRISPR/Cas9 / iPS細胞 / 筋萎縮性側索硬化症 / コホート / トランスオミックス / カルシウムイメージング / 視覚野 / 嗅球 / 神経回路 / レビー小体病型認知症 / 幻視 / レビー小体型認知症 / パーキンソン病 / α-シヌクレイン / RNA / 発達異常 / 運動ニューロン変性 / 髄液 / 脊髄性筋萎縮症 / RNAseq / 運動 / ミトコンドリア / ライフステージ / 神経分化 / 軸索 / Midkine-1 / 骨格筋 / テストステロン / 後根神経節 / エクソソーム / DREADD / エクソサイト-シス / カルシウムチャンネル / アンドロゲン受容体 / Src / DNAメチル化 / インスリン / エクソサイトーシス Less

孤発性ALS病態を反映した動物モデル作成とTDP-43凝集抑制療法の開発Principal Investigator
- Principal Investigator
  
  井口洋平
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  Nagoya University
ALSに関連する運動ニューロン周囲オリゴデンドロサイトの機能と役割の解明Principal Investigator
- Principal Investigator
  
  井口洋平
- Project Period (FY)
  2024 – 2025
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 52:General internal medicine and related fields
- Research Institution
  Nagoya University
Elucidation of temporal alteration in motor neuron-oligodendrocyte interaction in motor neuron diseases
- Principal Investigator
  
  勝野雅央
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 52:General internal medicine and related fields
- Research Institution
  Nagoya University
Study of synaptic pahtology caused by FUS in amyotrophic lateral sclerosis
- Principal Investigator
  
  横井聡
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  Nagoya University
Reserch to dicover disease pathogenesis of distal hereditary motor neuropathyPrincipal Investigator
- Principal Investigator
  
  Iguchi Yohei
- Project Period (FY)
  2022 – 2023
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 52:General internal medicine and related fields
- Research Institution
  Nagoya University
Therapeutic development against protein aggregation
- Principal Investigator
  
  佐橋健太郎
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  Nagoya University
Wide-field Ca imaging and trans-omics for mouse model of Lewy body disease
- Principal Investigator
  
  Katsuno Masahisa
- Project Period (FY)
  2021 – 2022
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 52:General internal medicine and related fields
- Research Institution
  Nagoya University
Spatio-temporal specificity of neurodegenerative diseases with a focus on very early life stages
- Principal Investigator
  
  Katsuno Masahisa
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 52:General internal medicine and related fields
- Research Institution
  Nagoya University
Unraveling mechanisms of In vivo transmission of aggregated TDP-43 in sporadic ALSPrincipal Investigator
- Principal Investigator
  
  Yohei Iguchi
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  Nagoya University
Understanding of defective developmental gene regulation responsible for motor neuron degeneration
- Principal Investigator
  
  Kentaro Sahashi
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 51030:Pathophysiologic neuroscience-related
- Research Institution
  Nagoya University
Discovery of novel target and disease modifying therapy for ALS/FTLD using neuro-specific transcriptome analysisPrincipal Investigator
- Principal Investigator
  
  IGUCHI YOHEI
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Nagoya University
Elucidation of defective neural communication in motor neuron diseases
- Principal Investigator
  
  Katsuno Masahisa
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Neurology
- Research Institution
  Nagoya University

All 2024 2023 2022 2021 2020 2019 2018 2017

All Journal Article Presentation Book

[Book] Pharma Medica2021
- Author(s)
  井口洋平、勝野雅央
- Total Pages
  6
- Publisher
  メディカルビュー社
- Data Source
  KAKENHI-PROJECT-20H03589
[Journal Article] Autoantibodies Against Dihydrolipoamide S-Acetyltransferase in Immune-Mediated Neuropathies.2024
- Author(s)
  Fukami Y, Iijima M, Koike H, Yagi S, Furukawa S, Mouri N, Ouchida J, Murakami A, Iida M, Yokoi S, Hashizume A, Iguchi Y, Imagama S, Katsuno M.
- Journal Title
  
  Neurol Neuroimmunol Neuroinflamm.
  
  Volume: 11(2) Issue: 2
- DOI
  10.1212/nxi.0000000000200199
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K14751, KAKENHI-PROJECT-23K06926, KAKENHI-PROJECT-22K19506, KAKENHI-PROJECT-22K15705
[Journal Article] IκB kinase phosphorylates cytoplasmic TDP-43 and promotes its proteasome degradation2024
- Author(s)
  Iguchi Yohei、Takahashi Yuhei、Li Jiayi、Araki Kunihiko、Amakusa Yoshinobu、Kawakami Yu、Kobayashi Kenta、Yokoi Satoshi、Katsuno Masahisa
- Journal Title
  
  Journal of Cell Biology
  
  Volume: 223 Issue: 2
- DOI
  10.1083/jcb.202302048
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K19506, KAKENHI-PROJECT-22K15707
[Journal Article] Neutrophil extracellular traps: from antimicrobial innate immunity to the development of chemotherapy-induced peripheral neuropathy2023
- Author(s)
  Koike Haruki、Iguchi Yohei、Sahashi Kentaro、Katsuno Masahisa
- Journal Title
  
  eBioMedicine
  
  Volume: 90 Pages: 104526-104526
- DOI
  10.1016/j.ebiom.2023.104526
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K19506, KAKENHI-PROJECT-20H03589, KAKENHI-PROJECT-20K07882
[Journal Article] Monomerization of TDP-43 is a key determinant for inducing TDP-43 pathology in amyotrophic lateral sclerosis2023
- Author(s)
  Oiwa Kotaro、Watanabe Seiji、Onodera Kazunari、Iguchi Yohei、Kinoshita Yukako、Komine Okiru、Sobue Akira、Okada Yohei、Katsuno Masahisa、Yamanaka Koji
- Journal Title
  
  Science Advances
  
  Volume: 9 Issue: 31
- DOI
  10.1126/sciadv.adf6895
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K15739, KAKENHI-PROJECT-23K14687, KAKENHI-PROJECT-19KK0214, KAKENHI-PROJECT-21K07471, KAKENHI-PROJECT-23K06826, KAKENHI-PROJECT-23K06955, KAKENHI-PROJECT-23K06975, KAKENHI-PROJECT-18K07539, KAKENHI-PROJECT-19K07969, KAKENHI-PROJECT-22K19506, KAKENHI-PROJECT-20K16488, KAKENHI-PROJECT-22H00467, KAKENHI-PROJECT-23K24249
[Journal Article] Mitochondria-associated membrane collapse impairs TBK1-mediated proteostatic stress response in ALS2023
- Author(s)
  Watanabe Seiji、Murata Yuri、Oka Yasuyoshi、Oiwa Kotaro、Horiuchi Mai、Iguchi Yohei、Komine Okiru、Sobue Akira、Katsuno Masahisa、Ogi Tomoo、Yamanaka Koji
- Journal Title
  
  Proceedings of the National Academy of Sciences
  
  Volume: 120 Issue: 47
- DOI
  10.1073/pnas.2315347120
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K14687, KAKENHI-PROJECT-19KK0214, KAKENHI-PROJECT-23K06826, KAKENHI-PROJECT-22K19506, KAKENHI-PROJECT-20K16488, KAKENHI-PROJECT-20H00629, KAKENHI-PROJECT-22H00467
[Journal Article] Simple and efficient differentiation of human iPSCs into contractible skeletal muscles for muscular disease modeling2023
- Author(s)
  Rashid Muhammad Irfanur、Ito Takuji、Miya Fuyuki、Shimojo Daisuke、Arimoto Kanae、Onodera Kazunari、Okada Rina、Nagashima Takunori、Yamamoto Kazuki、Khatun Zohora、Shimul Rayhanul Islam、Niwa Jun-ichi、Katsuno Masahisa、Sobue Gen、Okano Hideyuki、Sakurai Hidetoshi、Shimizu Kazunori、Doyu Manabu、Okada Yohei
- Journal Title
  
  Scientific Reports
  
  Volume: 13 Issue: 1 Pages: 8146-8146
- DOI
  10.1038/s41598-023-34445-9
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K15739, KAKENHI-PROJECT-22KJ2982, KAKENHI-PROJECT-21K07471, KAKENHI-PROJECT-23K06955, KAKENHI-PROJECT-23K06975, KAKENHI-PROJECT-18K07539, KAKENHI-PROJECT-19K07969, KAKENHI-PROJECT-20K16611, KAKENHI-PROJECT-23H00420, KAKENHI-PROJECT-23K24249
[Journal Article] Impaired disassembly of the axon initial segment restricts mitochondrial entry into damaged axons.2022
- Author(s)
  Kiryu-Seo S, Matsushita R, Tashiro R, Yoshimura T, Iguchi Y, Katsuno M, Ryosuke Takahashi R, Kiyama H
- Journal Title
  
  EMBO J
  
  Volume: 41 Issue: 20
- DOI
  10.15252/embj.2021110486
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K19310, KAKENHI-PROJECT-22K19506, KAKENHI-PROJECT-20H03589, KAKENHI-PROJECT-23K24695
[Journal Article] The SYNGAP1 3'UTR variant in ALS patients causes aberrant SYNGAP1 splicing and dendritic spine loss by recruiting HNRNPK2022
- Author(s)
  Yokoi S, Ito T, Sahashi K, Nakatochi M, Tohnai G, Nakamura R, Fujioka Y, Ishigaki S, Udagawa T, Izumi Y, Morita M, Kano O, Oda M, Sone T, Okano H, Atsuta N, Katsuno M, Okada Y*, Sobue G*
- Journal Title
  
  Journal of Neuroscience
  
  Volume: 42 Issue: 47 Pages: 8881-8896
- DOI
  10.1523/jneurosci.0455-22.2022
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07539, KAKENHI-PROJECT-19K07969, KAKENHI-PROJECT-19K07973, KAKENHI-PROJECT-21K07471, KAKENHI-PROJECT-22K07509, KAKENHI-PROJECT-22K07515, KAKENHI-PROJECT-22K07545, KAKENHI-PROJECT-20K16611, KAKENHI-PROJECT-21K15622, KAKENHI-PROJECT-17K19465, KAKENHI-PROJECT-18K15470, KAKENHI-PROJECT-19H03576, KAKENHI-PROJECT-23K24249, KAKENHI-PROJECT-23K21410
[Journal Article] Actin-binding protein filamin-A drives tau aggregation and contributes to progressive supranuclear palsy pathology2022
- Author(s)
  Tsujikawa K,Hamanaka K, Riku Y, Hattori Y, Hara N, Iguchi Y,Miyata T, Sobue G, Matsumoto N, Sahashi K, Katsuno M, et al.
- Journal Title
  
  Sci Adv
  
  Volume: - Issue: 21 Pages: 1-16
- DOI
  10.1126/sciadv.abm5029
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H00527, KAKENHI-PROJECT-22K19506, KAKENHI-PUBLICLY-21H05624, KAKENHI-PROJECT-20H00525, KAKENHI-PROJECT-20H03589, KAKENHI-PROJECT-20K07907, KAKENHI-PROJECT-21K15330, KAKENHI-PUBLICLY-21H00446, KAKENHI-PROJECT-22H04923, KAKENHI-PROJECT-23K21410, KAKENHI-PROJECT-21H03537
[Journal Article] Blockade of CHRNB2 signaling with a therapeutic monoclonal antibody attenuates the aggressiveness of gastric cancer cells2021
- Author(s)
  Kanda Mitsuro、Shimizu Dai、Nakamura Shunsuke、Sawaki Koichi、Umeda Shinichi、Miwa Takashi、Tanaka Haruyoshi、Inokawa Yoshikuni、Hattori Norifumi、Hayashi Masamichi、Tanaka Chie、Nakayama Goro、Iguchi Yohei、Katsuno Masahisa、Kodera Yasuhiro
- Journal Title
  
  Oncogene
  
  Volume: 40 Issue: 36 Pages: 5495-5504
- DOI
  10.1038/s41388-021-01945-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20H03589, KAKENHI-PROJECT-20H03750
[Journal Article] The wide-ranging clinical and genetic features in Japanese families with valosin-containing protein proteinopathy2021
- Author(s)
  Ando T, Nakamura R, Kuru S, Yokoi D, Atsuta N, Koike H, Suzuki M, Hara K, Iguchi Y, Harada Y, Yoshida Y, Hattori M, Murakami A, Noda S, Kimura S, Sone J, Nakamura T, Goto Y, Mano K, Okada H, Okuda S, Nishino I, Ogi T, Sobue G, Katsuno M
- Journal Title
  
  Neurobiology of Aging
  
  Volume: 100 Pages: 120.e1-120.e6
- DOI
  10.1016/j.neurobiolaging.2020.10.028
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07973, KAKENHI-PROJECT-20H03589
[Journal Article] Exploring the factors underlying remyelination arrest by studying the post‐transcriptional regulatory mechanisms of cystatin F gene2021
- Author(s)
  Li Jiayi、Durose Wilaiwan Wisessmith、Ito Junko、Kakita Akiyoshi、Iguchi Yohei、Katsuno Masahisa、Kunisawa Kazuo、Shimizu Takeshi、Ikenaka Kazuhiro
- Journal Title
  
  Journal of Neurochemistry
  
  Volume: 157 Issue: 6 Pages: 2070-2090
- DOI
  10.1111/jnc.15190
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20H03589, KAKENHI-PROJECT-20K16679
[Journal Article] Pathway from TDP-43-Related Pathology to Neuronal Dysfunction in Amyotrophic Lateral Sclerosis and Frontotemporal Lobar Degeneration2021
- Author(s)
  Riku Yuichi、Seilhean Danielle、Duyckaerts Charles、Boluda Susana、Iguchi Yohei、Ishigaki Shinsuke、Iwasaki Yasushi、Yoshida Mari、Sobue Gen、Katsuno Masahisa
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 22 Issue: 8 Pages: 3843-3843
- DOI
  10.3390/ijms22083843
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K16586, KAKENHI-PROJECT-20H03589, KAKENHI-PROJECT-23K21410
[Journal Article] Significance of Oligomeric and Fibrillar Species in Amyloidosis: Insights into Pathophysiology and Treatment2021
- Author(s)
  Koike Haruki、Iguchi Yohei、Sahashi Kentaro、Katsuno Masahisa
- Journal Title
  
  Molecules
  
  Volume: 26 Issue: 16 Pages: 5091-5091
- DOI
  10.3390/molecules26165091
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H03589
[Journal Article] Characteristic Features of FUS Inclusions in Spinal Motor Neurons of Sporadic Amyotrophic Lateral Sclerosis.2020
- Author(s)
  Ikenaka K, Ishigaki S, Iguchi Y, Kawai K, Fujioka Y, Yokoi S, Abdelhamid RF, Nagano S, Mochizuki H, Katsuno M, Sobue G.
- Journal Title
  
  J Neuropathol Exp Neurol
  
  Volume: 79 Issue: 4 Pages: 370-377
- DOI
  10.1093/jnen/nlaa003
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K09690, KAKENHI-PROJECT-17K09753, KAKENHI-PROJECT-18K07367, KAKENHI-PROJECT-20H03589
[Journal Article] Aggresome formation and liquid?liquid phase separation independently induce cytoplasmic aggregation of TAR DNA-binding protein 432020
- Author(s)
  Watanabe Seiji、Inami Hidekazu、Oiwa Kotaro、Murata Yuri、Sakai Shohei、Komine Okiru、Sobue Akira、Iguchi Yohei、Katsuno Masahisa、Yamanaka Koji
- Journal Title
  
  Cell Death & Disease
  
  Volume: 11 Issue: 10 Pages: 909-909
- DOI
  10.1038/s41419-020-03116-2
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K16488, KAKENHI-PROJECT-19KK0214, KAKENHI-PROJECT-20H03589, KAKENHI-PROJECT-18H02740, KAKENHI-PROJECT-17H04986
[Journal Article] NUS1 mutation in a family with epilepsy, cerebellar ataxia, and tremor2020
- Author(s)
  Araki Kunihiko、Nakamura Ryoichi、Ito Daisuke、Kato Kohji、Iguchi Yohei、Sahashi Kentaro、Toyama Miho、Hamada Kensuke、Okamoto Nobuhiko、Wada Yoshinao、Nakamura Tomohiko、Ogi Tomoo、Katsuno Masahisa
- Journal Title
  
  Epilepsy Research
  
  Volume: 164 Pages: 106371-106371
- DOI
  10.1016/j.eplepsyres.2020.106371
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20H03589
[Journal Article] Therapeutic monoclonal antibody targeting of neuronal pentraxin receptor to control metastasis in gastric cancer2020
- Author(s)
  Kanda Mitsuro、Shimizu Dai、Sawaki Koichi、Nakamura Shunsuke、Umeda Shinichi、Miwa Takashi、Tanaka Haruyoshi、Tanaka Chie、Hayashi Masamichi、Iguchi Yohei、Yamada Suguru、Katsuno Masahisa、Kodera Yasuhiro
- Journal Title
  
  Molecular Cancer
  
  Volume: 19 Issue: 1 Pages: 131-131
- DOI
  10.1186/s12943-020-01251-0
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20H03589
[Journal Article] TDP-43 regulates early-phase insulin secretion via CaV1.2-mediated exocytosis in islets2019
- Author(s)
  Araki Kunihiko、(他10名）、Ishigaki Shinsuke、Nakamichi Yoko、Tsunekawa Shin、Seino Yusuke、Yamamoto Akiko、Takayama Yasunori、Hidaka Shihomi、Tominaga Makoto、Ohara-Imaizumi Mica、Suzuki Atsushi、Ishiguro Hiroshi、Enomoto Atsushi、Yoshida Mari、Arima Hiroshi、Muramatsu Shin-ichi、Sobue Gen、Katsuno Masahisa
- Journal Title
  
  Journal of Clinical Investigation
  
  Volume: 129 Issue: 9 Pages: 3578-3593
- DOI
  10.1172/jci124481
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07367, KAKENHI-WRAPUP-19H05447, KAKENHI-PROJECT-17H04195, KAKENHI-PROJECT-17K08547, KAKENHI-PROJECT-17K09753
[Journal Article] Elevated serum creatine kinase in the early stage of sporadic amyotrophic lateral sclerosis.2019
- Author(s)
  Ito D, Hashizume A, Hijikata Y, Yamada S, Iguchi Y, Iida M, Kishimoto Y, Moriyoshi H, Hirakawa A, Katsuno M.
- Journal Title
  
  J Neurol.
  
  Volume: 266 Issue: 12 Pages: 2952-2961
- DOI
  10.1007/s00415-019-09507-6
- NAID
  120006786260
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H04195, KAKENHI-PROJECT-17J40128, KAKENHI-PROJECT-17K09753, KAKENHI-PROJECT-18K15361
[Journal Article] Preclinical progression of neurodegenerative diseases.2018
- Author(s)
  Katsuno M, Sahashi K, Iguchi Y, Hashizume A
- Journal Title
  
  Nagoya J Med Sci
  
  Volume: 80 Pages: 289-298
- NAID
  120006502462
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K09753
[Journal Article] Altered tau isoform ratio caused by loss of Fus and Sfpq function leads to FTLD-like phenotypes2017
- Author(s)
  Ishigaki S, Fujioka Y, Okada Y, Riku Y, Udagawa T, Honda D, Yokoi S, Endo K, Ikenaka K, Takagi S, Iguchi Y, Sahara N, Takashima A, Okano H, Yoshida M, Warita H, Aoki M, Watanabe H, Okado H, Katsuno H, Sobue G.
- Journal Title
  
  Cell Reports
  
  Volume: 18 Issue: 5 Pages: 1118-1131
- DOI
  10.1016/j.celrep.2017.01.013
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-15H01568, KAKENHI-PLANNED-26117002, KAKENHI-PLANNED-26117007, KAKENHI-PROJECT-26290016, KAKENHI-PROJECT-16K15480, KAKENHI-PROJECT-25640038, KAKENHI-PROJECT-16K14569, KAKENHI-PROJECT-17K09753, KAKENHI-ORGANIZER-26117001, KAKENHI-PROJECT-15H04278, KAKENHI-PLANNED-26117004, KAKENHI-PLANNED-26117008, KAKENHI-PROJECT-17H04195, KAKENHI-PROJECT-15K06793, KAKENHI-PROJECT-15K09310
[Presentation] Unveiling a novel role of phosphorylation of TDP-432023
- Author(s)
  Yohei Iguchi
- Organizer
  第64回日本神経学会学術大会
- Invited
- Data Source
  KAKENHI-PROJECT-22K19506
[Presentation] A novel reporter, TDP-DiLuc, detects TDP-43 monomerization preceding TDP-43 pathology2023
- Author(s)
  大岩康太郎, 渡邊征爾, 小野寺一成, 井口洋平, 岡田洋平, 勝野雅央, 山中宏二
- Organizer
  第64回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-22K19506
[Presentation] Dysregulated endocannabinoid system is a therapeutic target for amyotrophic lateral sclerosis2023
- Author(s)
  伊藤大輔, 橋詰淳, 井口洋平, 山田晋一郎, 岸本祥之, 小森祥太, 飯田円, 勝野雅央
- Organizer
  第64回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-22K19506
[Presentation] Research to understand and overcome ALS2023
- Author(s)
  Yohei Iguchi
- Organizer
  The 1st Fujita International Symposium on Brain Science
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K19506
[Presentation] Simple and efficient scarless genome-editing in patient-derived lymphoblastoid cell lines2023
- Author(s)
  Satoshi Yokoi, Ryoichi Nakamura, Genki Tohnai, Naoki Atsuta, Yohei Okada, Gen Sobue, Masahisa Katsuno
- Organizer
  第64回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-22K07515
[Presentation] Analysis of visual abnormalities in synucleinopathy2022
- Author(s)
  天草善信, 井口洋平, 横井聡, 川上裕, 勝野雅央
- Organizer
  第63回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-22K19506
[Presentation] Monomerization of TDP-43 is a key determinant for inducing TDP-43 pathology in ALS2022
- Author(s)
  大岩康太郎, 渡邊征爾, 小野寺一成, 井口洋平, 岡田洋平, 勝野雅央, 山中宏二
- Organizer
  第63回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-22K19506
[Presentation] Dysregulated endocannabinoid metabolism is a therapeutic target for amyotrophic lateral sclerosis2022
- Author(s)
  伊藤大輔, 橋詰淳, 山田晋一郎, 井口洋平, 岸本祥之, 鳥居良太, 飯田円, 勝野雅央
- Organizer
  第63回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-22K19506
[Presentation] Analysis of visual abnormalities in synucleinopathy2022
- Author(s)
  天草善信, 井口洋平, 横井聡, 川上裕, 勝野雅央
- Organizer
  第６３回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-20H03589
[Presentation] Monomerization of TDP-43 is a key determinant for inducing TDP-43 pathology in ALS2022
- Author(s)
  大岩康太郎, 渡邊征爾, 小野寺一成, 井口洋平, 岡田洋平, 勝野雅央, 山中宏二
- Organizer
  第６３回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-20H03589
[Presentation] Dysregulated endocannabinoid metabolism is a therapeutic target for amyotrophic lateral sclerosis2022
- Author(s)
  伊藤大輔, 橋詰淳, 山田晋一郎, 井口洋平, 岸本祥之, 鳥居良太, 飯田円, 勝野雅央
- Organizer
  第６３回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-20H03589
[Presentation] Monomerization of TDP-43 is a key determinant for inducing TDP-43 pathology in ALS2021
- Author(s)
  大岩康太郎, 渡邊征爾, 井口洋平, 勝野雅央, 山中宏二
- Organizer
  第６２回日本神経学会
- Data Source
  KAKENHI-PROJECT-20H03589
[Presentation] In vivo models of pathological TDP-43 transmission2021
- Author(s)
  井口洋平, 李佳益, 天草善信, 横井聡, 勝野雅央
- Organizer
  第６２回日本神経学会
- Data Source
  KAKENHI-PROJECT-20H03589
[Presentation] ALSのマウスモデルの有用性と特性2020
- Author(s)
  井口洋平
- Organizer
  第61回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-20H03589
[Presentation] ALSのマウスモデルの有用性と特性2020
- Author(s)
  井口洋平
- Organizer
  第61回日本神経学会学術大会
- Invited
- Data Source
  KAKENHI-PROJECT-20H00527
[Presentation] Secretion and propagation of TDP-43 as a therapeutic target for ALS.2020
- Author(s)
  Yohei Iguchi
- Organizer
  第43回日本神経科学大会 (Neuro2020)
- Data Source
  KAKENHI-PROJECT-20H03589
[Presentation] Secretion and propagation of TDP-43 as a therapeutic target for ALS.2020
- Author(s)
  Yohei Iguchi
- Organizer
  第43回日本神経科学大会 (Neuro2020)
- Invited
- Data Source
  KAKENHI-PROJECT-20H00527
[Presentation] TDP-43凝集におけるエンドソームの関わり2019
- Author(s)
  井口洋平、高橋裕平、李佳益、荒木邦彦、井汲一尋、勝野雅央
- Organizer
  第60回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-17K09753
[Presentation] Elevation of serum creatine kinase before the disease onset of amyotrophic lateral sclerosis2019
- Author(s)
  Daisuke Ito, Atsushi Hashizume, Yasuhiro Hijikata, Shinichiro Yamada, Yoshiyuki Kishimoto, Hideyuki Moriyoshi, Yohei Iguchi, Madoka Iida, Masahisa Katsuno
- Organizer
  第60回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-17K09753
[Presentation] Filamin-A as a novel driver for progressive supra nuclear palsy2019
- Author(s)
  Koyo Tsujikawa, kohei Hamanaka, Mari Yoshida, Kentaro Sahashi, Satoko Miyatake, Satomi Mihashi, Yohei Iguchi, Yuichi Riku, Shinsuke Ishigaki, Gen Sobue, Naomichi Matsumoto, Masahisa Katsuno
- Organizer
  第60回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-17K09753
[Presentation] Role of late endosome in the formation of TDP-43 cytoplasmic aggregation2019
- Author(s)
  Yuhei takahashi, Yohei Iguchi, Masahisa Katsuno
- Organizer
  第42回日本神経科学大会
- Data Source
  KAKENHI-PROJECT-17K09753
[Presentation] Exosome pathway: a key for clearance of pathological TDP-432018
- Author(s)
  Yohei Iguchi
- Organizer
  第５９回日本神経学会総会
- Invited
- Data Source
  KAKENHI-PROJECT-17K09753
[Presentation] Hereditary leukoencephalopathy with brain stem and spinal cord involvement2018
- Author(s)
  井口洋平, 熱田直樹, 勝野雅央
- Organizer
  第５９回日本神経学会総会
- Data Source
  KAKENHI-PROJECT-17K09753
[Presentation] THE ROLE OF TDP-43 SECRETION IN ASSOCIATION WITH EXOSOMES.2017
- Author(s)
  Yohei Iguchi, Lara Eid, Martin Parent, Yuichi Riku, Kaori Kawai, Mari Yoshida, Masahisa Katsuno, Gen Sobue, Jean-Pierre Julien
- Organizer
  XXIII World Congress of Neurology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04195
[Presentation] Emerging roles of exosomes in TDP-43 proteinopathy2017
- Author(s)
  Yohei Iguchi
- Organizer
  第60回日本神経化学会大会
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04195
[Presentation] Exosome secretion is a key pathway for clearance of pathological TDP-432017
- Author(s)
  Yohei Iguchi
- Organizer
  第40回日本神経科学大会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09753
[Presentation] Exosome secretion is a key pathway for clearance of pathological TDP-432017
- Author(s)
  Yohei Iguchi
- Organizer
  第40回日本神経科学大会
- Data Source
  KAKENHI-PROJECT-17H04195
[Presentation] THE ROLE OF TDP-43 SECRETION IN ASSOCIATION WITH EXOSOMES2017
- Author(s)
  Yohei Iguchi1, 2, Lara Eid1, Martin Parent1, Yuichi Riku2, Kaori Kawai, Mari Yoshida, Masahisa Katsuno, Gen Sobue, Jean-Pierre Julien
- Organizer
  XXIII World Congress of Neurology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09753
[Presentation] Emerging roles of exosomes in TDP-43 proteinopathy2017
- Author(s)
  Yohei Iguchi
- Organizer
  第60回日本神経化学会大会
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09753

1. Katsuno Masahisa (50402566)

# of Collaborated Projects: 12 results

# of Collaborated Products: 30 results
2. Kentaro Sahashi (90710103)

# of Collaborated Projects: 11 results

# of Collaborated Products: 6 results
3. 横井聡 (30815460)

# of Collaborated Projects: 6 results

# of Collaborated Products: 3 results
4. 飯田円 (40815437)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. 蛭薙智紀 (00927527)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. 橋詰淳 (00637689)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
7. 長野清一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 瀬尾寿美子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 熱田直樹

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 中村亮一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 石垣診祐

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 陸雄一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 小野寺一成

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
14. 岡田洋平

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
15. 伊藤卓治

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. 祖父江顕

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
17. 深見祐樹

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Iguchi Yohei 井口 洋平

IGUCHI YOHEI 井口 洋平

Research Projects

Research Products

Co-Researchers

孤発性ALS病態を反映した動物モデル作成とTDP-43凝集抑制療法の開発Principal Investigator

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ALSに関連する運動ニューロン周囲オリゴデンドロサイトの機能と役割の解明Principal Investigator

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Elucidation of temporal alteration in motor neuron-oligodendrocyte interaction in motor neuron diseases

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Study of synaptic pahtology caused by FUS in amyotrophic lateral sclerosis

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Reserch to dicover disease pathogenesis of distal hereditary motor neuropathyPrincipal Investigator

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Therapeutic development against protein aggregation

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Wide-field Ca imaging and trans-omics for mouse model of Lewy body disease

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Spatio-temporal specificity of neurodegenerative diseases with a focus on very early life stages

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Unraveling mechanisms of In vivo transmission of aggregated TDP-43 in sporadic ALSPrincipal Investigator

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Understanding of defective developmental gene regulation responsible for motor neuron degeneration

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Discovery of novel target and disease modifying therapy for ALS/FTLD using neuro-specific transcriptome analysisPrincipal Investigator

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Elucidation of defective neural communication in motor neuron diseases

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[Book] Pharma Medica2021

Author(s)

Total Pages

Iguchi Yohei 井口洋平

IGUCHI YOHEI 井口洋平