KAZUHIRO KOBUKE 小武家和博

Researcher Number	80805648
Other IDs
Affiliation (based on the past Project Information) *help	2023: 広島大学, その他の研究科, その他 2018 – 2021: 広島大学, 医系科学研究科(医), 寄附講座助教 2018: 広島大学, 医歯薬保健学研究科(医), 寄附講座助教 2017: 広島大学, 病院(医), 医科診療医
Review Section/Research Field	Principal Investigator Basic Section 53020:Cardiology-related / Endocrinology / Basic Section 54040:Metabolism and endocrinology-related
Keywords	Principal Investigator アルドステロン産生腺腫 / 原発性アルドステロン症 / アルドステロン / 二次性高血圧 / エピゲノム調節 / 副腎腫瘍 / 循環器・高血圧 / 内科 / 内分泌性高血圧 / DNAメチル化 … More / メタボローム / 腫瘍形成 / NADPH / 高血圧症 / 副腎 / 副腎皮質腫瘍 / ナトリウムイオンチャネル / 細胞増殖 / 二次性高血圧症 / 体細胞遺伝子変異 Less

小胞体ストレス応答を介したアルドステロン産生線種の発症および腫瘍増殖機構の解明Principal Investigator
- Principal Investigator
  
  小武家和博
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54040:Metabolism and endocrinology-related
- Research Institution
  Hiroshima University
ATP1A1変異により促進される細胞増殖および腫瘍形成機構の解明Principal Investigator
- Principal Investigator
  
  小武家和博
- Project Period (FY)
  2021 – 2022
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  Hiroshima University
Exploratory research of treatment target or marker for aldosterone producing adenoma by using of metabolome analysisPrincipal Investigator
- Principal Investigator
  
  Kobuke Kazuhiro
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  Hiroshima University
Discovery of aldosterone synthesis mechanisms and drug target via epigenomic regulationPrincipal Investigator
- Principal Investigator
  
  KAZUHIRO KOBUKE
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Endocrinology
- Research Institution
  Hiroshima University

All 2021 2018

All Journal Article Presentation

[Journal Article] ATP1A1 Mutant in Aldosterone-Producing Adenoma Leads to Cell Proliferation2021
- Author(s)
  Kobuke Kazuhiro、Oki Kenji、Gomez-Sanchez Celso E.、Gomez-Sanchez Elise P.、Itcho Kiyotaka、Ohno Haruya、Nagano Gaku、Yoshii Yoko、Baba Ryuta、Kodama Takaya、Arihiro Koji、Hattori Noboru、Yoneda Masayasu
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 22 Pages: 10981-10981
- DOI
  10.3390/ijms222010981
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K17964, KAKENHI-PROJECT-19K17972, KAKENHI-PROJECT-21K08557, KAKENHI-PROJECT-21K16058
[Journal Article] Purkinje Cell Protein 4 Expression Is Associated With DNA Methylation Status in Aldosterone-Producing Adenoma2018
- Author(s)
  Kobuke K, Oki K, Gomez-Sanchez CE, Ohno H, Itcho K, Yoshii Y, Yoneda M, Hattori N.
- Journal Title
  
  The Journal of Clinical Endocrinology & Metabolism
  
  Volume: 103 Pages: 965-971
- DOI
  10.1210/jc.2017-01996
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09883, KAKENHI-PROJECT-17K16166, KAKENHI-PROJECT-17H06894
[Journal Article] Aberrant G protein-receptor expression is associated with DNA methylation in aldosterone-producing adenoma2018
- Author(s)
  Itcho K, Oki K, Kobuke K, Yoshii Y, Ohno H, Yoneda M, Hattori N.
- Journal Title
  
  Molecular and Cellular Endocrinology
  
  Volume: 461 Pages: 100-104
- DOI
  10.1016/j.mce.2017.08.019
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K09883, KAKENHI-PROJECT-17K16166, KAKENHI-PROJECT-17H06894
[Presentation] The regulation of PCP4 transcription via DNA methylation in aldosterone-producing adenoma2018
- Author(s)
  Kiyotaka Itcho, Kenji Oki, Celso E, Gomez-Sanchez, Kazuhiro Kobuke, Yoko Yoshii, Haruya Ohno, Masayasu Yoneda
- Organizer
  42nd Meeting of the International Aldosterone Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H06894

1. Itcho Kiyotaka

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
2. Oki Kenji

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
3. 吉井陽子

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results

KAZUHIRO KOBUKE 小武家 和博

Research Projects

Research Products

Co-Researchers

小胞体ストレス応答を介したアルドステロン産生線種の発症および腫瘍増殖機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

ATP1A1変異により促進される細胞増殖および腫瘍形成機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Exploratory research of treatment target or marker for aldosterone producing adenoma by using of metabolome analysisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Discovery of aldosterone synthesis mechanisms and drug target via epigenomic regulationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] ATP1A1 Mutant in Aldosterone-Producing Adenoma Leads to Cell Proliferation2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Purkinje Cell Protein 4 Expression Is Associated With DNA Methylation Status in Aldosterone-Producing Adenoma2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Aberrant G protein-receptor expression is associated with DNA methylation in aldosterone-producing adenoma2018

Author(s)

Journal Title

DOI

Data Source

[Presentation] The regulation of PCP4 transcription via DNA methylation in aldosterone-producing adenoma2018

Author(s)

Organizer

Data Source

KAZUHIRO KOBUKE 小武家和博