Wiriyasermkul Pattama ＷｉｒｉｙａｓｅｒｍｋｕｌＰａｔｔａｍａ

Researcher Number	80825836
Other IDs
Affiliation (Current)	2025: 岩手大学, 農学部, 准教授
Affiliation (based on the past Project Information) *help	2023 – 2025: 岩手大学, 農学部, 准教授 2020 – 2023: 東京慈恵会医科大学, 医学部, 助教 2022: 東京慈恵会医科大学, 医学部, 講師 2020: 東京慈恵会医科大学, 医学部, 特任助教 2019: 奈良県立医科大学, 医学部, 助教
Review Section/Research Field	Principal Investigator Basic Section 38050:Food sciences-related / Basic Section 43030:Functional biochemistry-related / Basic Section 48040:Medical biochemistry-related Except Principal Investigator Basic Section 59040:Nutrition science and health science-related / Basic Section 53040:Nephrology-related
Keywords	Principal Investigator structure / transporter / amino acid / kidney / cystinuria / mass spectrometry / exchanger / homeostasis / HATs / amino acids … More / Mutation / Cystine / Kidney disease / SLC7 / Amino acids / Structure / Cystinuria / Transporter / cystine / cryo-EM / calcium / biogenesis … More Except Principal Investigator プロテオミクス / トランスポーター / ポリアミン代謝 / ポリアミン / メタボロミクス / D－アミノ酸 / 多階層的解析 / Dアミノ酸 / 多階層 / D-セリン / 腎臓 / マルチオミクス / D-アミノ酸 / 細胞老化 / 多発性嚢胞腎 / 細胞増殖 Less

トランスポータークラスターの分子機序解明による栄養素吸収の理解Principal Investigator
- Principal Investigator
  
  Wiriyasermkul Pattama
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 38050:Food sciences-related
- Research Institution
  Iwate University
生理活性物質の吸収メカニズムを担う輸送体分子群の同定と機能解析基盤の確立
- Principal Investigator
  
  永森收志
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  Jikei University School of Medicine
ポリアミンバランスの破綻がもたらす細胞死メカニズムの解析
- Principal Investigator
  
  田島彩沙
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  Jikei University School of Medicine
Molecular mechanism of amino acid harmonization: a paradigm of heterodimeric amino acid transportersPrincipal Investigator
- Principal Investigator
  
  Wiriyasermkul Pattama
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 43030:Functional biochemistry-related
- Research Institution
  Iwate University
  Jikei University School of Medicine
A multi-hierarchical approach uncovers the hidden physiological substrates of membrane transport proteins
- Principal Investigator
  
  Nagamori Shushi
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  Jikei University School of Medicine
Pathophysiological roles of cell senescence related gene in the polycystic kidney disease
- Principal Investigator
  
  Hatano Ryo
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53040:Nephrology-related
- Research Institution
  Chiba University
Molecular mechanism of the pathogenic protein interaction at the C-terminus of amino acid transporter b0,+AT/SLC7A9 in Japanese-type cystinuriaPrincipal Investigator
- Principal Investigator
  
  Wiriyasermkul Pattama
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 48040:Medical biochemistry-related
- Research Institution
  Jikei University School of Medicine
  Nara Medical University

All 2024 2023 2022 2021 2020 2019

All Journal Article Presentation

[Journal Article] Identification of three distinct cell populations for urate excretion in human kidneys2024
- Author(s)
  Sakaguchi Yoshihiko M.、Wiriyasermkul Pattama、Matsubayashi Masaya、Miyasaka Masaki、Sakaguchi Nau、Sahara Yoshiki、Takasato Minoru、Kinugawa Kaoru、Sugie Kazuma、Eriguchi Masahiro、Tsuruya Kazuhiko、Kuniyasu Hiroki、Nagamori Shushi、Mori Eiichiro
- Journal Title
  
  The Journal of Physiological Sciences
  
  Volume: 74 Issue: 1 Pages: 1-1
- DOI
  10.1186/s12576-023-00894-0
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K06150, KAKENHI-PROJECT-21H03365, KAKENHI-PROJECT-21H03801
[Journal Article] Parkinson's disease-associated ATP13A2/PARK9 functions as a lysosomal H+,K+-ATPase.2023
- Author(s)
  Takuto Fujii, Shushi Nagamori, Pattama Wiriyasermkul, Shizhou Zheng, Asaka Yago, Takahiro Shimizu, Yoshiaki Tabuchi, Tomoyuki Okumura, Tsutomu Fujii, Hiroshi Takeshima, Hideki Sakai
- Journal Title
  
  Nature communications
  
  Volume: 14 Issue: 1 Pages: 2174-2174
- DOI
  10.1038/s41467-023-37815-z
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07258, KAKENHI-PROJECT-23K24063, KAKENHI-PROJECT-22K06827, KAKENHI-PROJECT-21H03365
[Journal Article] Ca2+-mediated higher-order assembly of heterodimers in amino acid transport system b0,+ biogenesis and cystinuria2022
- Author(s)
  Lee Yongchan、Wiriyasermkul Pattama、Kongpracha Pornparn、Moriyama Satomi、Mills Deryck J.、Kuhlbrandt Werner、Nagamori Shushi
- Journal Title
  
  Nature Communications
  
  Volume: - Issue: 1 Pages: 2708-2708
- DOI
  10.1038/s41467-022-30293-9
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07373, KAKENHI-PROJECT-21H03365, KAKENHI-PROJECT-19H05648
[Journal Article] Simple but efficacious enrichment of integral membrane proteins and their interactions for in-depth membrane proteomics2022
- Author(s)
  Kongpracha Pornparn、Wiriyasermkul Pattama、Isozumi Noriyoshi、Moriyama Satomi、Kanai Yoshikatsu、Nagamori Shushi
- Journal Title
  
  Molecular & Cellular Proteomics
  
  Volume: - Issue: 5 Pages: 100206-100206
- DOI
  10.1016/j.mcpro.2022.100206
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07373, KAKENHI-PROJECT-19H03407, KAKENHI-PROJECT-21H03365, KAKENHI-PROJECT-19H05648
[Journal Article] Tmem174, a regulator of phosphate transporter prevents hyperphosphatemia.2022
- Author(s)
  Sasaki S, Shiozaki Y, Hanazaki A, Koike M, Tanifuji K, Uga M, Kawahara K, Kaneko I, Hasegawa T, Amizuka N, Miyamoto KI, Nagamori S, Kanai Y, Segawa H.
- Journal Title
  
  Scientific Reports
  
  Volume: 12巻1号 Issue: 1 Pages: 6353-6353
- DOI
  10.1038/s41598-022-10409-3
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K19585, KAKENHI-PROJECT-21K11594, KAKENHI-PROJECT-22K19404, KAKENHI-PROJECT-22K17800, KAKENHI-PROJECT-21H03365, KAKENHI-PROJECT-21H03375, KAKENHI-PROJECT-20K08637, KAKENHI-PROJECT-23K24071
[Journal Article] Insight into the function of a unique voltage-sensor protein (TMEM266) and its short form in mouse cerebellum2022
- Author(s)
  Kawai T、Narita H、Konno K、Akter S、Andriani RT、Iwasaki H、Nishikawa S、Yokoi N、Fukata Y、Fukata M、Wiriyasermkul P、Kongpracha P、Nagamori S、Takao K、Miyakawa T、Abe M、Sakimura K、Watanabe M、Nakagawa A、Okamura Y
- Journal Title
  
  Biochemical Journal
  
  Volume: 479 Issue: 11 Pages: 1127-1145
- DOI
  10.1042/bcj20220033
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K06451, KAKENHI-PROJECT-22K06805, KAKENHI-PROJECT-21K19350, KAKENHI-PROJECT-20KK0376, KAKENHI-PROJECT-18H05213, KAKENHI-PROJECT-20H00459, KAKENHI-PROJECT-19H03538, KAKENHI-PROJECT-21H03365, KAKENHI-PROJECT-22KF0249, KAKENHI-PROJECT-23K23986, KAKENHI-PROJECT-20K07274, KAKENHI-PLANNED-20H05791, KAKENHI-PROJECT-21H02444, KAKENHI-PROJECT-23K24066
[Journal Article] Inhibitory effect of a novel thiazolidinedione derivative on hepatitis B virus entry2021
- Author(s)
  Tanaka Tomohisa、Okuyama-Dobashi Kaori、Motohashi Ryoji、Yokoe Hiromasa、Takahashi Kazunori、Wiriyasermkul Pattama、Kasai Hirotake、Yamashita Atsuya、Maekawa Shinya、Enomoto Nobuyuki、Ryo Akihide、Nagamori Shushi、Tsubuki Masayoshi、Moriishi Kohji
- Journal Title
  
  Antiviral Research
  
  Volume: 194 Pages: 105165-105165
- DOI
  10.1016/j.antiviral.2021.105165
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07574, KAKENHI-PROJECT-19K08439, KAKENHI-PROJECT-20K08281, KAKENHI-PROJECT-19H05648, KAKENHI-PROJECT-21H03365
[Journal Article] Consensus mutagenesis approach improves the thermal stability of system xc- transporter, xCT, and enables cryo‐EM analyses2020
- Author(s)
  Oda Kazumasa、Lee Yongchan、Wiriyasermkul Pattama、Tanaka Yoko、Takemoto Mizuki、Yamashita Keitaro、Nagamori Shushi、Nishizawa Tomohiro、Nureki Osamu
- Journal Title
  
  Protein Science
  
  Volume: 29 Issue: 12 Pages: 2398-2407
- DOI
  10.1002/pro.3966
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07373, KAKENHI-PROJECT-18J21256, KAKENHI-PROJECT-20H03216, KAKENHI-PROJECT-19H05648
[Journal Article] ヒト栄養素トランスポーターと分子標的創薬研究2020
- Author(s)
  永森收志, 森山理美, パッタマウィリヤサムクン
- Journal Title
  
  化学と生物
  
  Volume: 58 Pages: 520-528
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07373
[Journal Article] D-Serine, an emerging biomarker of kidney diseases, is a hidden substrate of sodium-coupled monocarboxylate transporters2020
- Author(s)
  Wiriyasermkul Pattama、Moriyama Satomi、Tanaka Yoko、Kongpracha Pornparn、Nakamae Nodoka、Suzuki Masataka、Kimura Tomonori、Mita Masashi、Sasabe Jumpei、Nagamori Shushi
- Journal Title
  
  bioRxiv
  
  Volume: -
- DOI
  10.1101/2020.08.10.244822
- Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07373
[Journal Article] Membrane transport proteins in melanosomes: Regulation of ions for pigmentation2020
- Author(s)
  Wiriyasermkul Pattama、Moriyama Satomi、Nagamori Shushi
- Journal Title
  
  Biochimica et Biophysica Acta (BBA) - Biomembranes
  
  Volume: 1862 Issue: 12 Pages: 183318-183318
- DOI
  10.1016/j.bbamem.2020.183318
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07373, KAKENHI-PROJECT-19H05648
[Journal Article] Cryo-EM structure of the human L-type amino acid transporter 1 in complex with glycoprotein CD98hc2019
- Author(s)
  Lee Yongchan、Wiriyasermkul Pattama、Jin Chunhuan、Quan Lili、Ohgaki Ryuichi、Okuda Suguru、Kusakizako Tsukasa、Nishizawa Tomohiro、Oda Kazumasa、Ishitani Ryuichiro、Yokoyama Takeshi、Nakane Takanori、Shirouzu Mikako、Endou Hitoshi、Nagamori Shushi、Kanai Yoshikatsu、Nureki Osamu
- Journal Title
  
  Nature Structural & Molecular Biology
  
  Volume: 26 Issue: 6 Pages: 510-517
- DOI
  10.1038/s41594-019-0237-7
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06931, KAKENHI-PROJECT-19K07373, KAKENHI-PLANNED-16H06574, KAKENHI-PROJECT-17H03640, KAKENHI-PROJECT-19H03407, KAKENHI-PROJECT-18K19429, KAKENHI-PROJECT-16H06294
[Presentation] Structural Analysis Reveals the Biogenesis and Function of a Heterodimeric Amino Acid Transporter2024
- Author(s)
  Pattama Wiriyasermkul
- Organizer
  日本生理学会　第101回記念大会
- Invited
- Data Source
  KAKENHI-PROJECT-22K06150
[Presentation] Single-cell RNA-seqデータを用いた一細胞解像度でのヒト腎臓尿酸輸送モデルの構築2024
- Author(s)
  坂口義彦、WIRIYASERMKUL Pattama、宮坂政紀、永森收志
- Organizer
  第4回細胞形成研究会
- Data Source
  KAKENHI-PROJECT-21H03365
[Presentation] A multi-hierarchical approach explores non-canonical transport systems for nutrients2024
- Author(s)
  Pattama Wiriyasermkul
- Organizer
  2024 年度日本農芸化学会年度
- Invited
- Data Source
  KAKENHI-PROJECT-22K06150
[Presentation] Nutrient Transport Systems: From Prescription to Prevention2024
- Author(s)
  Pattama Wiriyasermkul
- Organizer
  第4回細胞形成研究会
- Invited
- Data Source
  KAKENHI-PROJECT-22K06150
[Presentation] Ca2+-mediated biogenesis of amino acid transporters and its implication in the development of cystinuria2023
- Author(s)
  Pattama Wiriyasermkul
- Organizer
  the 30th Federation of Asian and Oceanian Biochemists and Molecular Biologists Conference and the 8th International Conference on Biochemistry and Molecular Biology,
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K06150
[Presentation] Integrative multi-omics and synthetic biochemistry unveil the hidden functions of the known transporters2023
- Author(s)
  Wiriyasermkul Pattama
- Organizer
  日本生理学会　第100回記念大会
- Invited
- Data Source
  KAKENHI-PROJECT-22K06150
[Presentation] Integrative multi-omics and synthetic biochemistry unveil the hidden functions of the known transporters2023
- Author(s)
  Wiriyasermkul P. and Nagamori S.
- Organizer
  日本生理学会　第100回記念大会
- Invited
- Data Source
  KAKENHI-PROJECT-21H03365
[Presentation] Insight into the recognition of different substrates in amino acid transporters: from structural information to biochemical analyses.2022
- Author(s)
  Wiriyasermkul P. and Nagamori S.
- Organizer
  第 95 回日本生化学会大会
- Invited
- Data Source
  KAKENHI-PROJECT-21H03365
[Presentation] Insight into the recognition of different substrates in amino acid transporters: from structural information to biochemical analyses2022
- Author(s)
  Wiriyasermkul Pattama
- Organizer
  第 95 回日本生化学会大会
- Invited
- Data Source
  KAKENHI-PROJECT-22K06150
[Presentation] Biogenesis of heterodimeric amino acid transporter rBAT-b0,+AT2022
- Author(s)
  Wiriyasermkul Pattama
- Organizer
  第3回細胞形成研究会
- Invited
- Data Source
  KAKENHI-PROJECT-22K06150
[Presentation] Multi-hierarchical approach unveils unexpected transport proteins for D-serine, a biomarker for kidney injury2022
- Author(s)
  Wiriyasermkul Pattama
- Organizer
  Kanazawa University International Web Symposium
- Invited
- Data Source
  KAKENHI-PROJECT-19K07373
[Presentation] A combinatorial approach to enlighten hidden substrates of the renowned transporters2021
- Author(s)
  Wiriyasermkul Pattama
- Organizer
  第94回日本生化学会大会
- Invited
- Data Source
  KAKENHI-PROJECT-19K07373
[Presentation] Biogenesis and function of rBAT-b0,+AT: a heterodimeric amino acid transporter2021
- Author(s)
  Wiriyasermkul Pattama、Lee Yongchan、Kuhlbrandt Werner、Nagamori Shushi
- Organizer
  2021 年度生理研研究会
- Invited
- Data Source
  KAKENHI-PROJECT-19K07373
[Presentation] Ca2+を介した高次構造形成は、ヘテロ二量体アミノ酸トランスポーター b0,+AT-rBATの生合成において重要なステップである2021
- Author(s)
  Wiriyasermkul Pattama、Lee Yongchan、Kongpracha Pornparn、Kuhlbrandt Werner、Nagamori Shushi
- Organizer
  第 138 回成医会総会
- Data Source
  KAKENHI-PROJECT-19K07373
[Presentation] Function and structure of heterodimeric amino acid transporters2020
- Author(s)
  Wiriyasermkul P, Nagamori S.
- Organizer
  Ron Kaback博士追悼記念第二回細胞形成研究会
- Invited
- Data Source
  KAKENHI-PROJECT-19K07373
[Presentation] Function and structure of heterodimeric amino acid transporters: toward the understanding of their physiological properties and pharmaceutical relevance2020
- Author(s)
  Wiriyasermkul P, Nagamori S
- Organizer
  The 140th Annual Meeting of the Pharmaceutical Society of Japan
- Invited
- Data Source
  KAKENHI-PROJECT-19K07373
[Presentation] Function and structure of heterodimeric amino acid transporters2019
- Author(s)
  Wiriyasermkul P, Nagamori S
- Organizer
  生体コモンスペース研究会
- Data Source
  KAKENHI-PROJECT-19K07373
[Presentation] Proteomics and phosphoproteomics of brain organoids2019
- Author(s)
  Wiriyasermkul P, Nagamori S
- Organizer
  ASUKA symposium
- Invited
- Data Source
  KAKENHI-PROJECT-19K07373
[Presentation] Combination of structural and biochemical approaches reveals transport mechanism of Nucleobase/ascorbate transporter2019
- Author(s)
  Wiriyasermkul P, Quick M
- Organizer
  The 92nd annual meeting of the Japanese Biochemical Society
- Invited
- Data Source
  KAKENHI-PROJECT-19K07373

1. Nagamori Shushi (90467572)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
2. 田島彩沙 (20780688)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. Hatano Ryo (60521713)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. Kongpracha Pornparn (70817767)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 伊藤素行 (20377906)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 三木隆司 (50302568)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 李勇燦 (00894932)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 笹部潤平 (10398612)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 西山賢一 (80291334)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. OHGAKI Ryuichi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. FUJII Takuto

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. コンプラシャポーンパン

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results
13. 網塚憲生

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 横井紀彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. 田中智久

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Wiriyasermkul Pattama Ｗｉｒｉｙａｓｅｒｍｋｕｌ Ｐａｔｔａｍａ

Research Projects

Research Products

Co-Researchers

トランスポータークラスターの分子機序解明による栄養素吸収の理解Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

生理活性物質の吸収メカニズムを担う輸送体分子群の同定と機能解析基盤の確立

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

ポリアミンバランスの破綻がもたらす細胞死メカニズムの解析

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Molecular mechanism of amino acid harmonization: a paradigm of heterodimeric amino acid transportersPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

A multi-hierarchical approach uncovers the hidden physiological substrates of membrane transport proteins

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Pathophysiological roles of cell senescence related gene in the polycystic kidney disease

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Molecular mechanism of the pathogenic protein interaction at the C-terminus of amino acid transporter b0,+AT/SLC7A9 in Japanese-type cystinuriaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Identification of three distinct cell populations for urate excretion in human kidneys2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Parkinson's disease-associated ATP13A2/PARK9 functions as a lysosomal H+,K+-ATPase.2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Ca2+-mediated higher-order assembly of heterodimers in amino acid transport system b0,+ biogenesis and cystinuria2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Simple but efficacious enrichment of integral membrane proteins and their interactions for in-depth membrane proteomics2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Tmem174, a regulator of phosphate transporter prevents hyperphosphatemia.2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Insight into the function of a unique voltage-sensor protein (TMEM266) and its short form in mouse cerebellum2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Inhibitory effect of a novel thiazolidinedione derivative on hepatitis B virus entry2021

Author(s)

Journal Title

DOI

Wiriyasermkul Pattama ＷｉｒｉｙａｓｅｒｍｋｕｌＰａｔｔａｍａ