Sakai Toshihiko 坂井利彦

Researcher Number	80847012
Other IDs	https://orcid.org/0000-0002-7484-6944
Affiliation (Current)	2026: 国立研究開発法人国立がん研究センター, 中央病院, 医員
Affiliation (based on the past Project Information) *help	2021 – 2025: 国立研究開発法人国立がん研究センター, 中央病院, 医員 2024: 東京大学, 医学部附属病院, 助教 2022: 東京大学, 医学部附属病院, 助教 2020: 東京大学, 医学部附属病院, 助教
Review Section/Research Field	Principal Investigator Basic Section 56050:Otorhinolaryngology-related Except Principal Investigator Basic Section 56050:Otorhinolaryngology-related
Keywords	Principal Investigator 交感神経 / 蛍光イメージング / FAK / 上皮間葉移行 / DOI / 上皮間葉転換 / 簇出 / 予後予測 / 再帰的回帰分析 / 腫瘍微小環境 … More / 蔟出 / 腫瘍間質比 / 神経周囲浸潤 / 舌癌 / 口腔癌 … More Except Principal Investigator 頭頸部癌 / 治療感受性予測 / 酸素飽和度イメージング内視鏡 / exosome / biomarker / 免疫チェックポイント阻害薬 / 抗PD－１抗体 / バイオマーカー / エクソソーム / 抗PD-1抗体 Less

酸素飽和度イメージング内視鏡による頭頸部癌化学放射線治療感受性予測プログラム開発
- Principal Investigator
  
  岡野渉
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56050:Otorhinolaryngology-related
- Research Institution
  National Cancer Center Japan
Establishment of a liquid biomarker using peripheral blood exosomes in patients with recurrent head and neck cancer.
- Principal Investigator
  
  Fukuoka Osamu
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56050:Otorhinolaryngology-related
- Research Institution
  The University of Tokyo
Prediction of lymph node metastasis in early stage oral cancer with focus on tumor budding and epithelial-mesenchymal transitionPrincipal Investigator
- Principal Investigator
  
  Sakai Toshihiko
- Project Period (FY)
  2020 – 2024
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 56050:Otorhinolaryngology-related
- Research Institution
  National Cancer Center Japan
  The University of Tokyo

All 2025 2024 2023 2022

All Journal Article Presentation

[Journal Article] Prognostic prediction using recursive partitioning analysis of patients undergoing salvage surgery for locally recurrent oral squamous cell carcinoma2025
- Author(s)
  Sakai Toshihiko、Omura Go、Eguchi Kohtaro、Sakai Azusa、Matsumoto Yoshifumi、Fushimi Chihiro、Yoshimoto Seiichi
- Journal Title
  
  International Journal of Clinical Oncology
  
  Volume: - Issue: 6 Pages: 1118-1126
- DOI
  10.1007/s10147-025-02739-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K18272, KAKENHI-PROJECT-24K12662
[Journal Article] Efficacy of Chemotherapy After Immune Checkpoint Inhibitor Discontinuation in Head and Neck Cancer2024
- Author(s)
  Fukuoka Osamu、Saito Yuki、Mukai Toshiyuki、Hayashi Takaaki、Yamamura Koji、Sakai Toshihiko、Kobayashi Kenya、Akashi Ken、Yoshida Masafumi、Ando Mizuo、Yamasoba Tatsuya
- Journal Title
  
  The Laryngoscope
  
  Volume: 134 Issue: 1 Pages: 228-235
- DOI
  10.1002/lary.30851
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K09578
[Journal Article] Ultra‐high combined positive score and high serum albumin are favorable prognostic biomarkers for immune checkpoint inhibitors in head and neck squamous cell carcinoma2023
- Author(s)
  Saito Yuki、Kobayashi Kenya、Fukuoka Osamu、Sakai Toshihiko、Yamamura Koji、Ando Mizuo、Kondo Kenji
- Journal Title
  
  Head & Neck
  
  Volume: 46 Issue: 2 Pages: 367-377
- DOI
  10.1002/hed.27576
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K09556, KAKENHI-PROJECT-21K09578
[Journal Article] Examination of optimal initial treatment for Stage Ⅲ p16-positive oropharyngeal squamous cell carcinoma2023
- Author(s)
  Kuriyama Masakazu、Saito Yuki、Sakai Toshihiko、Omura Go、Fukuoka Osamu、Akashi Ken、Yoshida Masashi、Ando Mizuo、Asakage Takahiro、Yamasoba Tatsuya
- Journal Title
  
  JOURNAL OF JAPAN SOCIETY FOR HEAD AND NECK SURGERY
  
  Volume: 32 Issue: 3 Pages: 245-250
- DOI
  10.5106/jjshns.32.245
- ISSN
  1349-581X, 1884-474X
- Language
  Japanese
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K09578
[Journal Article] Tumor-stroma ratio can predict lymph-node metastasis in cT1/2N0 oral tongue squamous cell carcinoma independent of tumor budding grade2022
- Author(s)
  Sakai Toshihiko、Saito Yuki、Tateishi Yoko、Yamazawa Sho、Fukuoka Osamu、Kobayashi Kenya、Omura Go、Akashi Ken、Yoshida Masafumi、Ando Mizuo、Ebihara Yasuhiro、Yamasoba Tatsuya
- Journal Title
  
  International Journal of Clinical Oncology
  
  Volume: 27 Issue: 12 Pages: 1818-1827
- DOI
  10.1007/s10147-022-02249-y
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K09556, KAKENHI-PROJECT-21K09578, KAKENHI-PROJECT-20K18272, KAKENHI-PROJECT-18K09339
[Journal Article] Usefulness of circulating tumor DNA by targeting human papilloma virus-derived sequences as a biomarker in p16-positive oropharyngeal cancer.2022
- Author(s)
  Akashi K, Sakai T, Fukuoka O, Saito Y, Yoshida M, Ando M, Ito T, Murakami Y, Yamasoba T.
- Journal Title
  
  Scientific Reports
  
  Volume: 12 Issue: 1 Pages: 572-572
- DOI
  10.1038/s41598-021-04307-3
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K21539, KAKENHI-PROJECT-18K16833, KAKENHI-PROJECT-20H03525, KAKENHI-PROJECT-21K07091, KAKENHI-PROJECT-21K09556, KAKENHI-PROJECT-21K09578, KAKENHI-PROJECT-22K09726
[Journal Article] Clinical Study of Prognostic Factors in Patients with P16-positive Oropharyngeal Cancer in Whom Surgery Was Selected as The Initial Treatment2022
- Author(s)
  Kan Seikei、Saito Yuki、Sakai Toshihiko、Fukuoka Osamu、Ando Mizuo、Yamasoba Tatsuya
- Journal Title
  
  Nippon Jibiinkoka Tokeibugeka Gakkai Kaiho(Tokyo)
  
  Volume: 125 Issue: 6 Pages: 986-992
- DOI
  10.3950/jibiinkotokeibu.125.6_986
- ISSN
  2436-5793, 2436-5866
- Year and Date
  2022-06-20
- Language
  Japanese
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K09578
[Presentation] 口腔癌の病理形態学的評価に基づく予後予測、　並びに交感神経軸索新生と神経周囲浸潤に関する多コホート研究2025
- Author(s)
  坂井　利彦
- Organizer
  本郷・信濃町ジョイントカンファレンス
- Invited
- Data Source
  KAKENHI-PROJECT-20K18272
[Presentation] 局所再発口腔扁平上皮癌の救済手術における再帰分割分析による予後予測2024
- Author(s)
  坂井利彦、小村豪、林崇明、相原勇介、三輪好、江口紘太郎坂井梓、松本吉史、伏見千宙、吉本世一
- Organizer
  日本頭頸部癌学会
- Data Source
  KAKENHI-PROJECT-20K18272
[Presentation] 病理形態学的評価（Budding、腫瘍間質比）による舌癌予後因子の検討2022
- Author(s)
  坂井利彦、齊藤祐毅、立石陽子、山澤翔、山村晃司、福岡修、安藤瑞生、山岨達也
- Organizer
  第31回　日本頭頸部外科学会
- Data Source
  KAKENHI-PROJECT-20K18272
[Presentation] 病理形態学的評価（Budding、腫瘍間質比）による舌癌予後因子の検討2022
- Author(s)
  坂井利彦、齊藤祐毅、立石陽子、山澤翔、山村晃司、福岡修、安藤瑞生、山岨達也
- Organizer
  頭頸部外科学会
- Data Source
  KAKENHI-PROJECT-20K18272

1. Fukuoka Osamu (80779794)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
2. 岡野渉 (10554420)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 白倉聡 (00420266)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 富澤建斗 (20970429)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 山下大生 (40970835)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 砂川弘憲 (50844792)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 松浦一登 (70271947)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 矢野友規 (70505883)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 小山正平 (80767559)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 向川卓志 (90601039)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 齊藤祐毅

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
12. 村上善則

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 伊東剛

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Sakai Toshihiko 坂井 利彦

Research Projects

Research Products

Co-Researchers

酸素飽和度イメージング内視鏡による頭頸部癌化学放射線治療感受性予測プログラム開発

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Establishment of a liquid biomarker using peripheral blood exosomes in patients with recurrent head and neck cancer.

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Prediction of lymph node metastasis in early stage oral cancer with focus on tumor budding and epithelial-mesenchymal transitionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Prognostic prediction using recursive partitioning analysis of patients undergoing salvage surgery for locally recurrent oral squamous cell carcinoma2025

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Efficacy of Chemotherapy After Immune Checkpoint Inhibitor Discontinuation in Head and Neck Cancer2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Ultra‐high combined positive score and high serum albumin are favorable prognostic biomarkers for immune checkpoint inhibitors in head and neck squamous cell carcinoma2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Examination of optimal initial treatment for Stage Ⅲ p16-positive oropharyngeal squamous cell carcinoma2023

Author(s)

Journal Title

DOI

ISSN

Language

Data Source

[Journal Article] Tumor-stroma ratio can predict lymph-node metastasis in cT1/2N0 oral tongue squamous cell carcinoma independent of tumor budding grade2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Usefulness of circulating tumor DNA by targeting human papilloma virus-derived sequences as a biomarker in p16-positive oropharyngeal cancer.2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Clinical Study of Prognostic Factors in Patients with P16-positive Oropharyngeal Cancer in Whom Surgery Was Selected as The Initial Treatment2022

Author(s)

Journal Title

DOI

ISSN

Year and Date

Language

Data Source

[Presentation] 口腔癌の病理形態学的評価に基づく予後予測、 並びに交感神経軸索新生と神経周囲浸潤に関する 多コホート研究2025

Author(s)

Organizer

Data Source

[Presentation] 局所再発口腔扁平上皮癌の救済手術における 再帰分割分析による予後予測2024

Author(s)

Organizer

Data Source

[Presentation] 病理形態学的評価（Budding、腫瘍間質比）による舌癌予後因子の検討2022

Author(s)

Organizer

Data Source

[Presentation] 病理形態学的評価（Budding、腫瘍間質比）による舌癌予後因子の検討2022

Author(s)

Organizer

Data Source

Sakai Toshihiko 坂井利彦

[Presentation] 口腔癌の病理形態学的評価に基づく予後予測、　並びに交感神経軸索新生と神経周囲浸潤に関する多コホート研究2025

[Presentation] 局所再発口腔扁平上皮癌の救済手術における再帰分割分析による予後予測2024