Koyama Syohei 小山正平

… Alternative Names

Koyama Shohei 小山正平

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Researcher Number	80767559
Other IDs	https://orcid.org/0000-0002-6897-9417
Affiliation (Current)	2023: 国立研究開発法人国立がん研究センター, 先端医療開発センター, ユニット長 2023: 大阪大学, 大学院医学系研究科, 特任准教授
Affiliation (based on the past Project Information) *help	2019 – 2022: 大阪大学, 医学系研究科, 特任助教 2020 – 2021: 国立研究開発法人国立がん研究センター, 先端医療開発センター, ユニット長 2018 – 2019: 大阪大学, 医学系研究科, 助教 2017: 大阪大学, 大学院医学系研究科, 助教(常勤) 2016 – 2017: 大阪大学, 免疫学フロンティア研究センター, 特任助教(常勤) 2015: 大阪大学, 学内共同利用施設等, 助教
Review Section/Research Field	Principal Investigator Respiratory organ internal medicine / Basic Section 50020:Tumor diagnostics and therapeutics-related Except Principal Investigator Basic Section 59040:Nutrition science and health science-related / Respiratory organ internal medicine / Medical pharmacy / Medium-sized Section 47:Pharmaceutical sciences and related fields / Basic Section 90110:Biomedical engineering-related
Keywords	Principal Investigator がん免疫 / 好中球 / 抗PD-1抗体 / 肺がん / 非小細胞肺癌 / 活性化好中球 / 腫瘍浸潤T細胞 / 免疫療法耐性化 / 免疫チェックポイント阻害薬 / 末梢血T細胞 / 免疫チェックポイント阻害 / 長期治療効果 / TCRレパトア … More Except Principal Investigator … More 骨髄由来免疫抑制細胞 / パルミチン酸 / がん免疫 / 肺癌 / 癌微小環境 / 内在性リガンド / アポトーシス小体 / 無菌的炎症誘導 / 化学療法抵抗性 / Toll様受容体 / 微小環境 / 無菌的炎症 / 腫瘍関連マクロファージ / 腫瘍関連線維芽細胞 / MyD88 / 内在性リガント / 機能性ペプチド / 送達担体 / ワクチン / 免疫改変 / 感染症 / 創薬 / 薬学 / ペプチド / アレルギー / ダイレクトリプログラミング / 線維芽細胞 / 血管内皮細胞 / 転写因子 / エピジェネティクス / 脂肪酸 / がん / 免疫 / MDSC / 超音波 / マイクロバブル / がん免疫療法 / 腫瘍内免疫微小環境 / 養子免疫療法 / イムノモジュレーション / 乳がん / T細胞免疫療法 / CAR-T細胞免疫療法 / 代謝 Less

Regulation of myeloid-derived suppressor cells by palmitic acid metabolism for next-generation cancer immunotherapy
- Principal Investigator
  
  立花雅史
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  Osaka University
Basic evaluation and investigation of the factors linked to the long term response to immunotherapiesPrincipal Investigator
- Principal Investigator
  
  小山正平
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  National Cancer Center Japan
ダイレクトリプログラミング技術を用いた新しい線維化疾患治療法の開発
- Principal Investigator
  
  岡田欣晃
- Project Period (FY)
  2020 – 2021
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 47:Pharmaceutical sciences and related fields
- Research Institution
  Osaka University
Development of novel cancer therapy based on promotion of tumor infiltrating lymphocyte by the immunomodulation with ultrasound technology
- Principal Investigator
  
  鈴木亮
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 90110:Biomedical engineering-related
- Research Institution
  Teikyo University
脂肪酸代謝から解き明かす骨髄由来免疫抑制細胞の制御メカニズムとがん治療への応用
- Principal Investigator
  
  立花雅史
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  Osaka University
Regulating the sensitivity of lung cancer to immunotherapy through inhibiting neutrophil activation and promoting T cell infiltration in tumorsPrincipal Investigator
- Principal Investigator
  
  Koyama Shohei
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Osaka University
Development of peptides that target immune cells and their application for therapy of immune-related diseases
- Principal Investigator
  
  Yoshioka Yasuo
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Medical pharmacy
- Research Institution
  Osaka University
Developing novel lung cancer therapy targetting cancer cell intrinsic ligands
- Principal Investigator
  
  Kijima Takashi
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Osaka University

All 2022 2019 2018 2017

All Journal Article Presentation

[Journal Article] Bronchoalveolar lavage fluid reveals factors contributing to the efficacy of PD-1 blockade in lung cancer2022
- Author(s)
  Masuhiro Kentaro et al.
- Journal Title
  
  JCI Insight.
  
  Volume: - Pages: 1-1
- DOI
  10.1172/jci.insight.157915
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21H03538, KAKENHI-PROJECT-19K08650, KAKENHI-PROJECT-21K07252
[Journal Article] Lactic acid promotes PD-1 expression in regulatory T cells in highly glycolytic tumor microenvironments2022
- Author(s)
  Shogo Kumagai, Shohei Koyama, Kota Itahashi, Tokiyoshi Tanegashima, Yi-tzu Lin, Yosuke Togashi, Takahiro Kamada, Takuma Irie, Genki Okumura, Hidetoshi Kono, et al.
- Journal Title
  
  Cancer Cell
  
  Volume: 40 Pages: 201-218
- DOI
  10.1016/j.ccell.2022.01.001
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H06162, KAKENHI-PROJECT-20H03461, KAKENHI-PROJECT-20H03694, KAKENHI-PROJECT-20H04519, KAKENHI-PROJECT-21H02772, KAKENHI-PROJECT-21J01784, KAKENHI-PROJECT-20K07383, KAKENHI-PROJECT-20K08531, KAKENHI-PROJECT-21K07112, KAKENHI-PROJECT-21K07252, KAKENHI-PROJECT-21K12117, KAKENHI-PROJECT-16H06279
[Journal Article] Suppression of Myeloid Cell Arginase Activity leads to Therapeutic Response in a NSCLC Mouse Model by Activating Anti-Tumor Immunity2019
- Author(s)
  Miret Juan J.、Kirschmeier Paul、Koyama Shohei、Zhu Mingrui、Li Yvonne Y.、Naito Yujiro、Wu Min、Malladi Venkat S.、Huang Wei、Walker William、Palakurthi Sangeetha、Dranoff Glenn、Hammerman Peter S.、Pecot Chad V.、Wong Kwok-Kin、Akbay Esra A.
- Journal Title
  
  Journal for ImmunoTherapy of Cancer
  
  Volume: 7 Pages: 32-32
- DOI
  10.1186/s40425-019-0504-5
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K16045
[Journal Article] Semaphorin 7A promotes EGFR-TKI resistance in EGFR mutant lung adenocarcinoma cells2018
- Author(s)
  Kinehara Y, Nagatomo I, Koyama S,（30名飛ばして）, Kida H, Kumanogoh A
- Journal Title
  
  JCI Insight
  
  Volume: 3
- DOI
  10.1172/jci.insight.123093
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K09537, KAKENHI-PROJECT-17K16045, KAKENHI-PROJECT-18H05282
[Journal Article] Selecting suitable chemotherapies for PD-1/PD-L1 blockade to optimize the tumor immune microenvironment2018
- Author(s)
  Koyama Shohei、Nagatomo Izumi、Kijima Takashi、Kumanogoh Atsushi
- Journal Title
  
  Oncotarget
  
  Volume: 9 Pages: 32552-32553
- DOI
  10.18632/oncotarget.26028
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K16045, KAKENHI-PROJECT-18H05282
[Journal Article] Clinical implications of monitoring nivolumab immunokinetics in non-small cell lung cancer patients2018
- Author(s)
  Osa A, Uenami T, Koyama S, （22名飛ばして）, Kida H, Akbay EA, Hammerman PS, Wong KK, Dranoff G, Mori M, Kijima T, Kumanogoh A
- Journal Title
  
  JCI Insight
  
  Volume: 3
- DOI
  10.1172/jci.insight.59125
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09537, KAKENHI-PROJECT-17K16045, KAKENHI-PROJECT-18H05282
[Journal Article] Interleukin-17A Promotes Lung Tumor Progression through Neutrophil Attraction to Tumor Sites and Mediating Resistance to PD-1 Blockade2017
- Author(s)
  Akbay Esra A.、Koyama Shohei、Liu Yan、Dries Ruben、Bufe Lauren E.、Silkes Michael、Alam MD Maksudul、Magee Dillon M.、Jones Robert、Jinushi Masahisa、Osa Akio、Kumanogoh Atsushi、Freeman Gordon J.、Awad Mark M.、Christiani David C.、Bueno Raphael、Hammerman Peter S.、Dranoff Glenn、Wong Kwok-Kin
- Journal Title
  
  Journal of Thoracic Oncology
  
  Volume: 12 Pages: 1268-1279
- DOI
  10.1016/j.jtho.2017.04.017
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K16045
[Presentation] マイクロバブルと超音波併用による免疫微小環境の変化と養子免疫療法の抗腫瘍効果増強に関する基礎的検討2022
- Author(s)
  丸山　保、宗像理紗、小俣大樹、萩原芙美子、鈴木悠乃、小山正平、岡田欣晃、工藤信樹、鈴木　亮
- Organizer
  日本薬学会第142年会
- Data Source
  KAKENHI-PROJECT-20H04519
[Presentation] 免疫抑制的な腫瘍内微小環境を有する腫瘍への効果的ながん免疫療法構築に向けた基礎的研究2022
- Author(s)
  宗像理紗、青枝大貴、小山正平、小俣大樹、丸山　保、鈴木悠乃、萩原芙美子、岡田欣晃、吉岡靖雄、鈴木　亮
- Organizer
  日本薬学会第142年会
- Data Source
  KAKENHI-PROJECT-20H04519
[Presentation] 臨床におけるがん免疫治療のdata gapとTranslational Research2019
- Author(s)
  小山　正平
- Organizer
  第 23 回日本がん免疫学会総会
- Invited
- Data Source
  KAKENHI-PROJECT-17K16045
[Presentation] Analysis of whole blood cell as a predictive marker in nivolumab-treated non-small cell lung cancer patients2018
- Author(s)
  Akio Osa , Yujiro Naito , Shohei Koyama , Takeshi Uenami , Masahide Mori , Atsushi Kumanogoh
- Organizer
  SITC(Society for Immunotherapy of Cancer) 2018 Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K16045
[Presentation] Monitoring Nivolumab Binding as a Method to Clarify the Residual Therapeutic Effects in Previously Treated Lung Cancer Patients2017
- Author(s)
  A. Osa, S. Koyama, T. Uenami, K. Fujimoto, Y. Naito, H. Hirata, T. Takimoto, I. Nagatomo, Y. Takeda, H. Kida, M. Mori, T. Kijima, A. Kumanogoh
- Organizer
  World Conference on Lung Cancer 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K16045
[Presentation] Monitoring Nivolumab Binding as a Method to Clarify the Residual Therapeutic Effects in Previously Treated Lung Cancer Patients.2017
- Author(s)
  A. Osa, S. Koyama, T. Uenami, K. Fujimoto, Y. Naito, H. Hirata, T. Takimoto, I. Nagatomo, Y. Takeda, H. Kida, M. Mori, T. Kijima, A. Kumanogoh
- Organizer
  World Conference on Lung Cancer, Oct 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09220

1. 岡田欣晃 (50444500)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
2. 立花雅史 (80513449)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. Kijima Takashi (90372614)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
4. Yoshioka Yasuo (00392308)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 南俊行 (00705113)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 長彰翁 (20751390)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 森村治 (80743765)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 内藤祐二朗 (30800982)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 黒田悦史 (10299604)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 青枝大貴 (10324344)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 樋野展正 (90469916)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 原田和生 (50397741)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 鈴木亮 (90384784)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
14. 工藤信樹 (30271638)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
15. KIDA Hiroshi

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
16. Doi Toshihiko

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
17. 熊郷淳

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
18. 西川博嘉

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
19. 河野隆志

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
20. 谷田部恭

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
21. 冨樫庸介

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Koyama Syohei 小山 正平

Koyama Shohei 小山 正平

Research Projects

Research Products

Co-Researchers

Regulation of myeloid-derived suppressor cells by palmitic acid metabolism for next-generation cancer immunotherapy

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Basic evaluation and investigation of the factors linked to the long term response to immunotherapiesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

ダイレクトリプログラミング技術を用いた新しい線維化疾患治療法の開発

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of novel cancer therapy based on promotion of tumor infiltrating lymphocyte by the immunomodulation with ultrasound technology

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

脂肪酸代謝から解き明かす骨髄由来免疫抑制細胞の制御メカニズムとがん治療への応用

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Regulating the sensitivity of lung cancer to immunotherapy through inhibiting neutrophil activation and promoting T cell infiltration in tumorsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of peptides that target immune cells and their application for therapy of immune-related diseases

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Developing novel lung cancer therapy targetting cancer cell intrinsic ligands

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Bronchoalveolar lavage fluid reveals factors contributing to the efficacy of PD-1 blockade in lung cancer2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Lactic acid promotes PD-1 expression in regulatory T cells in highly glycolytic tumor microenvironments2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Suppression of Myeloid Cell Arginase Activity leads to Therapeutic Response in a NSCLC Mouse Model by Activating Anti-Tumor Immunity2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Semaphorin 7A promotes EGFR-TKI resistance in EGFR mutant lung adenocarcinoma cells2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Selecting suitable chemotherapies for PD-1/PD-L1 blockade to optimize the tumor immune microenvironment2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Clinical implications of monitoring nivolumab immunokinetics in non-small cell lung cancer patients2018

Author(s)

Koyama Syohei 小山正平

Koyama Shohei 小山正平