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Koyama Syohei  小山 正平

… Alternative Names

Koyama Shohei  小山 正平

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Researcher Number 80767559
Other IDs
  • ORCIDhttps://orcid.org/0000-0002-6897-9417
Affiliation (Current) 2023: 国立研究開発法人国立がん研究センター, 先端医療開発センター, ユニット長
2023: 大阪大学, 大学院医学系研究科, 特任准教授
Affiliation (based on the past Project Information) *help 2019 – 2022: 大阪大学, 医学系研究科, 特任助教
2020 – 2021: 国立研究開発法人国立がん研究センター, 先端医療開発センター, ユニット長
2018 – 2019: 大阪大学, 医学系研究科, 助教
2017: 大阪大学, 大学院医学系研究科, 助教(常勤)
2016 – 2017: 大阪大学, 免疫学フロンティア研究センター, 特任助教(常勤)
2015: 大阪大学, 学内共同利用施設等, 助教
Review Section/Research Field
Principal Investigator
Respiratory organ internal medicine / Basic Section 50020:Tumor diagnostics and therapeutics-related
Except Principal Investigator
Basic Section 59040:Nutrition science and health science-related / Respiratory organ internal medicine / Medical pharmacy / Medium-sized Section 47:Pharmaceutical sciences and related fields / Basic Section 90110:Biomedical engineering-related
Keywords
Principal Investigator
がん免疫 / 好中球 / 抗PD-1抗体 / 肺がん / 非小細胞肺癌 / 活性化好中球 / 腫瘍浸潤T細胞 / 免疫療法耐性化 / 免疫チェックポイント阻害薬 / 末梢血T細胞 / 免疫チェックポイント阻害 / 長期治療効果 / TCRレパトア … More
Except Principal Investigator
… More 骨髄由来免疫抑制細胞 / パルミチン酸 / がん免疫 / 肺癌 / 癌微小環境 / 内在性リガンド / アポトーシス小体 / 無菌的炎症誘導 / 化学療法抵抗性 / Toll様受容体 / 微小環境 / 無菌的炎症 / 腫瘍関連マクロファージ / 腫瘍関連線維芽細胞 / MyD88 / 内在性リガント / 機能性ペプチド / 送達担体 / ワクチン / 免疫改変 / 感染症 / 創薬 / 薬学 / ペプチド / アレルギー / ダイレクトリプログラミング / 線維芽細胞 / 血管内皮細胞 / 転写因子 / エピジェネティクス / 脂肪酸 / がん / 免疫 / MDSC / 超音波 / マイクロバブル / がん免疫療法 / 腫瘍内免疫微小環境 / 養子免疫療法 / イムノモジュレーション / 乳がん / T細胞免疫療法 / CAR-T細胞免疫療法 / 代謝 Less
  • Research Projects

    (8 results)
  • Research Products

    (13 results)
  • Co-Researchers

    (21 People)
  •  Regulation of myeloid-derived suppressor cells by palmitic acid metabolism for next-generation cancer immunotherapy

    • Principal Investigator
      立花 雅史
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 59040:Nutrition science and health science-related
    • Research Institution
      Osaka University
  •  Basic evaluation and investigation of the factors linked to the long term response to immunotherapiesPrincipal Investigator

    • Principal Investigator
      小山 正平
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 50020:Tumor diagnostics and therapeutics-related
    • Research Institution
      National Cancer Center Japan
  •  ダイレクトリプログラミング技術を用いた新しい線維化疾患治療法の開発

    • Principal Investigator
      岡田 欣晃
    • Project Period (FY)
      2020 – 2021
    • Research Category
      Grant-in-Aid for Challenging Research (Exploratory)
    • Review Section
      Medium-sized Section 47:Pharmaceutical sciences and related fields
    • Research Institution
      Osaka University
  •  Development of novel cancer therapy based on promotion of tumor infiltrating lymphocyte by the immunomodulation with ultrasound technology

    • Principal Investigator
      鈴木 亮
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 90110:Biomedical engineering-related
    • Research Institution
      Teikyo University
  •  脂肪酸代謝から解き明かす骨髄由来免疫抑制細胞の制御メカニズムとがん治療への応用

    • Principal Investigator
      立花 雅史
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 59040:Nutrition science and health science-related
    • Research Institution
      Osaka University
  •  Regulating the sensitivity of lung cancer to immunotherapy through inhibiting neutrophil activation and promoting T cell infiltration in tumorsPrincipal Investigator

    • Principal Investigator
      Koyama Shohei
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Respiratory organ internal medicine
    • Research Institution
      Osaka University
  •  Development of peptides that target immune cells and their application for therapy of immune-related diseases

    • Principal Investigator
      Yoshioka Yasuo
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Medical pharmacy
    • Research Institution
      Osaka University
  •  Developing novel lung cancer therapy targetting cancer cell intrinsic ligands

    • Principal Investigator
      Kijima Takashi
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Respiratory organ internal medicine
    • Research Institution
      Osaka University

All 2022 2019 2018 2017

All Journal Article Presentation

  • [Journal Article] Bronchoalveolar lavage fluid reveals factors contributing to the efficacy of PD-1 blockade in lung cancer2022

    • Author(s)
      Masuhiro Kentaro et al.
    • Journal Title

      JCI Insight.

      Volume: - Pages: 1-1

    • DOI

      10.1172/jci.insight.157915

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21H03538, KAKENHI-PROJECT-19K08650, KAKENHI-PROJECT-21K07252
  • [Journal Article] Lactic acid promotes PD-1 expression in regulatory T cells in highly glycolytic tumor microenvironments2022

    • Author(s)
      Shogo Kumagai, Shohei Koyama, Kota Itahashi, Tokiyoshi Tanegashima, Yi-tzu Lin, Yosuke Togashi, Takahiro Kamada, Takuma Irie, Genki Okumura, Hidetoshi Kono, et al.
    • Journal Title

      Cancer Cell

      Volume: 40 Pages: 201-218

    • DOI

      10.1016/j.ccell.2022.01.001

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17H06162, KAKENHI-PROJECT-20H03461, KAKENHI-PROJECT-20H03694, KAKENHI-PROJECT-20H04519, KAKENHI-PROJECT-21H02772, KAKENHI-PROJECT-21J01784, KAKENHI-PROJECT-20K07383, KAKENHI-PROJECT-20K08531, KAKENHI-PROJECT-21K07112, KAKENHI-PROJECT-21K07252, KAKENHI-PROJECT-21K12117, KAKENHI-PROJECT-16H06279
  • [Journal Article] Suppression of Myeloid Cell Arginase Activity leads to Therapeutic Response in a NSCLC Mouse Model by Activating Anti-Tumor Immunity2019

    • Author(s)
      Miret Juan J.、Kirschmeier Paul、Koyama Shohei、Zhu Mingrui、Li Yvonne Y.、Naito Yujiro、Wu Min、Malladi Venkat S.、Huang Wei、Walker William、Palakurthi Sangeetha、Dranoff Glenn、Hammerman Peter S.、Pecot Chad V.、Wong Kwok-Kin、Akbay Esra A.
    • Journal Title

      Journal for ImmunoTherapy of Cancer

      Volume: 7 Pages: 32-32

    • DOI

      10.1186/s40425-019-0504-5

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K16045
  • [Journal Article] Semaphorin 7A promotes EGFR-TKI resistance in EGFR mutant lung adenocarcinoma cells2018

    • Author(s)
      Kinehara Y, Nagatomo I, Koyama S,(30名飛ばして), Kida H, Kumanogoh A
    • Journal Title

      JCI Insight

      Volume: 3

    • DOI

      10.1172/jci.insight.123093

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16K09537, KAKENHI-PROJECT-17K16045, KAKENHI-PROJECT-18H05282
  • [Journal Article] Selecting suitable chemotherapies for PD-1/PD-L1 blockade to optimize the tumor immune microenvironment2018

    • Author(s)
      Koyama Shohei、Nagatomo Izumi、Kijima Takashi、Kumanogoh Atsushi
    • Journal Title

      Oncotarget

      Volume: 9 Pages: 32552-32553

    • DOI

      10.18632/oncotarget.26028

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K16045, KAKENHI-PROJECT-18H05282
  • [Journal Article] Clinical implications of monitoring nivolumab immunokinetics in non-small cell lung cancer patients2018

    • Author(s)
      Osa A, Uenami T, Koyama S, (22名飛ばして), Kida H, Akbay EA, Hammerman PS, Wong KK, Dranoff G, Mori M, Kijima T, Kumanogoh A
    • Journal Title

      JCI Insight

      Volume: 3

    • DOI

      10.1172/jci.insight.59125

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K09537, KAKENHI-PROJECT-17K16045, KAKENHI-PROJECT-18H05282
  • [Journal Article] Interleukin-17A Promotes Lung Tumor Progression through Neutrophil Attraction to Tumor Sites and Mediating Resistance to PD-1 Blockade2017

    • Author(s)
      Akbay Esra A.、Koyama Shohei、Liu Yan、Dries Ruben、Bufe Lauren E.、Silkes Michael、Alam MD Maksudul、Magee Dillon M.、Jones Robert、Jinushi Masahisa、Osa Akio、Kumanogoh Atsushi、Freeman Gordon J.、Awad Mark M.、Christiani David C.、Bueno Raphael、Hammerman Peter S.、Dranoff Glenn、Wong Kwok-Kin
    • Journal Title

      Journal of Thoracic Oncology

      Volume: 12 Pages: 1268-1279

    • DOI

      10.1016/j.jtho.2017.04.017

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K16045
  • [Presentation] マイクロバブルと超音波併用による免疫微小環境の変化と養子免疫療法の抗腫瘍効果増強に関する基礎的検討2022

    • Author(s)
      丸山 保、宗像理紗、小俣大樹、萩原芙美子、鈴木悠乃、小山正平、岡田欣晃、工藤信樹、鈴木 亮
    • Organizer
      日本薬学会第142年会
    • Data Source
      KAKENHI-PROJECT-20H04519
  • [Presentation] 免疫抑制的な腫瘍内微小環境を有する腫瘍への効果的ながん免疫療法構築に向けた基礎的研究2022

    • Author(s)
      宗像理紗、青枝大貴、小山正平、小俣大樹、丸山 保、鈴木悠乃、萩原芙美子、岡田欣晃、吉岡靖雄、鈴木 亮
    • Organizer
      日本薬学会第142年会
    • Data Source
      KAKENHI-PROJECT-20H04519
  • [Presentation] 臨床におけるがん免疫治療のdata gapとTranslational Research2019

    • Author(s)
      小山 正平
    • Organizer
      第 23 回日本がん免疫学会総会
    • Invited
    • Data Source
      KAKENHI-PROJECT-17K16045
  • [Presentation] Analysis of whole blood cell as a predictive marker in nivolumab-treated non-small cell lung cancer patients2018

    • Author(s)
      Akio Osa , Yujiro Naito , Shohei Koyama , Takeshi Uenami , Masahide Mori , Atsushi Kumanogoh
    • Organizer
      SITC(Society for Immunotherapy of Cancer) 2018 Annual Meeting
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K16045
  • [Presentation] Monitoring Nivolumab Binding as a Method to Clarify the Residual Therapeutic Effects in Previously Treated Lung Cancer Patients2017

    • Author(s)
      A. Osa, S. Koyama, T. Uenami, K. Fujimoto, Y. Naito, H. Hirata, T. Takimoto, I. Nagatomo, Y. Takeda, H. Kida, M. Mori, T. Kijima, A. Kumanogoh
    • Organizer
      World Conference on Lung Cancer 2017
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K16045
  • [Presentation] Monitoring Nivolumab Binding as a Method to Clarify the Residual Therapeutic Effects in Previously Treated Lung Cancer Patients.2017

    • Author(s)
      A. Osa, S. Koyama, T. Uenami, K. Fujimoto, Y. Naito, H. Hirata, T. Takimoto, I. Nagatomo, Y. Takeda, H. Kida, M. Mori, T. Kijima, A. Kumanogoh
    • Organizer
      World Conference on Lung Cancer, Oct 2017
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K09220
  • 1.  岡田 欣晃 (50444500)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 2 results
  • 2.  立花 雅史 (80513449)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 3.  Kijima Takashi (90372614)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 4.  Yoshioka Yasuo (00392308)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 5.  南 俊行 (00705113)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 6.  長 彰翁 (20751390)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  森村 治 (80743765)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  内藤 祐二朗 (30800982)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 9.  黒田 悦史 (10299604)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  青枝 大貴 (10324344)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  樋野 展正 (90469916)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  原田 和生 (50397741)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  鈴木 亮 (90384784)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 14.  工藤 信樹 (30271638)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 15.  KIDA Hiroshi
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 16.  Doi Toshihiko
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 17.  熊郷 淳
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 3 results
  • 18.  西川 博嘉
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 19.  河野 隆志
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 20.  谷田部 恭
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 21.  冨樫 庸介
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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