Yamaguchi Hiroshi 山口宏

Researcher Number	80851849
Other IDs
Affiliation (Current)	2026: 神戸大学, 医学系研究科(医), 特命講師
Affiliation (based on the past Project Information) *help	2026: 神戸大学, 医学研究科, 特命講師 2024: 神戸大学, 医学研究科, 特命講師 2023: 神戸大学, 医学研究科, 特命助教 2023: 神戸大学, 医学部附属病院, 特定助教 2022: 神戸大学, 医学研究科, 助教 2020 – 2021: 神戸大学, 医学研究科, 特命助教
Review Section/Research Field	Principal Investigator Basic Section 55060:Emergency medicine-related
Keywords	Principal Investigator 簡易脳波 / 急性脳炎 / てんかん / 急性脳症 / 救急外来 / 意識障害 / 熱性けいれん / 非けいれん性発作 / 非けいれん性てんかん重積 / 持続脳波 … More / 熱性発作 / S100B / GDF-15 / AESD / 簡易脳波モニタリングシステム / 非けいれん性てんかん重積状態 / 神経障害 / 集中治療室 / 小児 / てんかん重積 / 脳波 Less

小児急性脳症の網羅的疾患関連遺伝子探索と多角的機能解析による病態解明Principal Investigator
- Principal Investigator
  
  山口宏
- Project Period (FY)
  2026 – 2028
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55060:Emergency medicine-related
- Research Institution
  Kobe University
持続脳波による急性脳症のNCSの病態と神経傷害機構の解明Principal Investigator
- Principal Investigator
  
  山口宏
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 55060:Emergency medicine-related
- Research Institution
  Kobe University
Elucidation of the Neurological Damage Mechanism in Non-Convulsive Seizures Utilizing Continuous EEG Data from Emergency DepartmentsPrincipal Investigator
- Principal Investigator
  
  Yamaguchi Hiroshi
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 55060:Emergency medicine-related
- Research Institution
  Kobe University

All 2025 2024 2023 2021 2020

All Journal Article Presentation

[Journal Article] Epidemiology and treatment trends for acute encephalopathy under the impact of SARS-CoV-2 pandemic based on a prospective multicenter consecutive case registry2025
- Author(s)
  Tokumoto Shoichi、Nishiyama Masahiro、Yamaguchi Hiroshi、Sano Kentaro、Motobayashi Mitsuo、Kashiwagi Mitsuru、Hattori Yuka、Maruyama Azusa、Toyoshima Daisaku、Nakagawa Taku、Kawano Go、Nagase Hiroaki
- Journal Title
  
  Journal of the Neurological Sciences
  
  Volume: 469 Pages: 123377-123377
- DOI
  10.1016/j.jns.2024.123377
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K09119, KAKENHI-PROJECT-23K15615, KAKENHI-PROJECT-23K15630
[Journal Article] Elevated cerebrospinal fluid neuronal injury biomarkers within 24?hours of onset in infection-triggered acute encephalopathy compared to complex febrile seizures2024
- Author(s)
  Oikawa Shizuka、Yamaguchi Hiroshi、Nishiyama Masahiro、Ito Tatsuhito、Kawamura Aoi、Sameshima Tomohiro、Soma Kento、Ueda Takuya、Tokumoto Shoichi、Ishida Yusuke、Kurosawa Hiroshi、Nozu Kandai、Maruyama Azusa、Tanaka Ryojiro、Nagase Hiroaki
- Journal Title
  
  Journal of the Neurological Sciences
  
  Volume: 466 Pages: 123238-123238
- DOI
  10.1016/j.jns.2024.123238
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K09047, KAKENHI-PROJECT-22K09119, KAKENHI-PROJECT-23K15615, KAKENHI-PROJECT-23K15630
[Journal Article] Efficacy and safety of buccal midazolam for seizures outside the hospital: Real-world clinical experience2024
- Author(s)
  Ueda Takuya、Nishiyama Masahiro、Yamaguchi Hiroshi、Soma Kento、Ishida Yusuke、Maruyama Azusa、Nozu Kandai、Nagase Hiroaki
- Journal Title
  
  Brain and Development
  
  Volume: 46 Issue: 10 Pages: 332-338
- DOI
  10.1016/j.braindev.2024.09.005
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K09119, KAKENHI-PROJECT-23K15615
[Journal Article] Timing of therapeutic interventions against infection-triggered encephalopathy syndrome: a scoping review of the pediatric literature2023
- Author(s)
  Nagase Hiroaki、Yamaguchi Hiroshi、Tokumoto Shoichi、Ishida Yusuke、Tomioka Kazumi、Nishiyama Masahiro、Nozu Kandai、Maruyama Azusa
- Journal Title
  
  Frontiers in Neuroscience
  
  Volume: 17 Pages: 1150868-1150868
- DOI
  10.3389/fnins.2023.1150868
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K15615, KAKENHI-PROJECT-22K09119, KAKENHI-PROJECT-20K17894
[Journal Article] Clinical and laboratory characteristics of complex febrile seizures in the acute phase: a case-series study in Japan2023
- Author(s)
  Tanaka Tsukasa、Yamaguchi Hiroshi、Ishida Yusuke、Tomioka Kazumi、Nishiyama Masahiro、Toyoshima Daisaku、Maruyama Azusa、Takeda Hiroki、Kurosawa Hiroshi、Tanaka Ryojiro、Nozu Kandai、Nagase Hiroaki
- Journal Title
  
  BMC Neurology
  
  Volume: 23 Issue: 1 Pages: 28-28
- DOI
  10.1186/s12883-023-03051-7
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K09047, KAKENHI-PROJECT-22K09119, KAKENHI-PROJECT-22K15941, KAKENHI-PROJECT-23K15615, KAKENHI-PROJECT-19K18353, KAKENHI-PROJECT-20K17894
[Journal Article] Dravet syndrome and hemorrhagic shock and encephalopathy syndrome associated with an intronic deletion of SCN1A2023
- Author(s)
  Hanafusa H, Yamaguchi H, Kondo H, Nagasaka M, Juan Ye M, Oikawa S, Tokumoto S, Tomioka K, Nishiyama M, Morisada N, Matsuo M, Nozu K, Nagase H.
- Journal Title
  
  Brain Dev.
  
  Volume: 45 Issue: 6 Pages: 317-323
- DOI
  10.1016/j.braindev.2023.01.008
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K09119, KAKENHI-PROJECT-22K15941, KAKENHI-PROJECT-23K15615, KAKENHI-PROJECT-19K18353, KAKENHI-PROJECT-20K17894
[Journal Article] Time course of serum cytokine level changes within 72?h after onset in children with acute encephalopathy and febrile seizures2023
- Author(s)
  Tomioka Kazumi、Nishiyama Masahiro、Tokumoto Shoichi、Yamaguchi Hiroshi、Aoki Kazunori、Seino Yusuke、Toyoshima Daisaku、Kurosawa Hiroshi、Tada Hiroko、Sakuma Hiroshi、Nozu Kandai、Maruyama Azusa、Tanaka Ryojiro、Iijima Kazumoto、Nagase Hiroaki
- Journal Title
  
  BMC Neurology
  
  Volume: 23 Issue: 1 Pages: 7-7
- DOI
  10.1186/s12883-022-03048-8
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K09047, KAKENHI-PROJECT-22K07831, KAKENHI-PROJECT-22K09119, KAKENHI-PROJECT-22K15941, KAKENHI-PROJECT-23K15615, KAKENHI-PROJECT-19K18353, KAKENHI-PROJECT-20K17894
[Journal Article] Early non-convulsive seizures are associated with the development of acute encephalopathy with biphasic seizures and late reduced diffusion2021
- Author(s)
  Maruyama A, Tokumoto S, Yamaguchi H, Ishida Y, Tanaka T, Tomioka K, Nishiyama M, Fujita K, Toyoshima D, Nagase H
- Journal Title
  
  Brain Dev
  
  Volume: 43 Issue: 4 Pages: 548-555
- DOI
  10.1016/j.braindev.2020.11.012
- NAID
  120007002555
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K17894, KAKENHI-PROJECT-18K08918, KAKENHI-PROJECT-18K15711, KAKENHI-PROJECT-21K09047, KAKENHI-PROJECT-19K18353
[Journal Article] Elevated cytokine, chemokine, and growth and differentiation factor-15 levels in hemorrhagic shock and encephalopathy syndrome: A retrospective observational study2021
- Author(s)
  Yamaguchi Hiroshi、Nishiyama Masahiro、Tokumoto Shoichi、Ishida Yusuke、Tomioka Kazumi、Aoki Kazunori、Seino Yusuke、Toyoshima Daisaku、Takeda Hiroki、Kurosawa Hiroshi、Sakuma Hiroshi、Tada Hiroko、Nozu Kandai、Maruyama Azusa、Tanaka Ryojiro、Iijima Kazumoto、Nagase Hiroaki
- Journal Title
  
  Cytokine
  
  Volume: 137 Pages: 155324-155324
- DOI
  10.1016/j.cyto.2020.155324
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K08311, KAKENHI-PROJECT-20K17894, KAKENHI-PROJECT-18K08918, KAKENHI-PROJECT-18K15711, KAKENHI-PROJECT-19K18353
[Journal Article] Prediction of AESD and neurological sequelae in febrile status epilepticus2021
- Author(s)
  Nishiyama M, Ishida Y, Yamaguchi H, Tokumoto S, Tomioka K, Hongo H, Toyoshima D, Maruyama A, Kurosawa H, Tanaka R, Nozu K, Iijima K, Nagase H
- Journal Title
  
  Brain Dev
  
  Volume: 43 Issue: 5 Pages: 616-625
- DOI
  10.1016/j.braindev.2021.01.004
- NAID
  120007028964
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K17894, KAKENHI-PROJECT-18K08918, KAKENHI-PROJECT-18K15711, KAKENHI-PROJECT-21K09047, KAKENHI-PROJECT-19K18353
[Journal Article] Thiamylal anaesthetic therapy for febrile refractory status epilepticus in children2020
- Author(s)
  Ishida Y, Nishiyama M, Yamaguchi H, Tomioka K, Tanaka T, Takeda H, Tokumoto S, Toyoshima D, Maruyama A, Seino Y, Aoki K, Nozu K, Nishimura N, Kurosawa H, Iijima K, Nagase H
- Journal Title
  
  Seizure
  
  Volume: 80 Pages: 12-17
- DOI
  10.1016/j.seizure.2020.03.012
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K17894, KAKENHI-PROJECT-18K15711
[Journal Article] Detailed characteristics of acute encephalopathy with biphasic seizures and late reduced diffusion: 18-year data of a single-center consecutive cohort.2020
- Author(s)
  Yamaguchi H, Nishiyama M, Tokumoto S, Ishida Y, Tomioka K, Aoki K, Seino Y, Toyoshima D, Takeda H, Kurosawa H, Nozu K, Maruyama A, Tanaka R, Iijima K, Nagase H.
- Journal Title
  
  J Neurol Sci.
  
  Volume: 411 Pages: 116684-116684
- DOI
  10.1016/j.jns.2020.116684
- NAID
  120006846525
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K08918, KAKENHI-PROJECT-18K15711, KAKENHI-PROJECT-19K18353, KAKENHI-PROJECT-20K17894
[Presentation] 有熱性てんかん重積状態における髄液神経傷害バイオマーカーの検討2024
- Author(s)
  老川静香、山口宏、伊藤立人、相馬健人、川村葵、上田拓耶、鮫島智大、京野由紀、徳元翔一、石田悠介、西山将広、丸山あずさ、野津寛大、永瀬裕朗
- Organizer
  第66回日本小児神経学会学術集会
- Data Source
  KAKENHI-PROJECT-23K15615
[Presentation] 急性脳症患者における治療介入前後の血清GDF-15の経時的推移2024
- Author(s)
  山口宏、伊藤立人、相馬健人、川村葵、鮫島智大、京野由紀、上田拓耶、老川静香、徳元翔一、石田悠介、西山将広、丸山あずさ、野津寛大、永瀬裕朗
- Organizer
  第66回日本小児神経学会学術集会
- Data Source
  KAKENHI-PROJECT-23K15615
[Presentation] 意識障害を呈した小児に対する救急外来簡易脳波の原因疾患別特徴2023
- Author(s)
  山口　宏、上田　拓耶、老川　静香、徳元　翔一、西山　将広、丸山　あずさ、野津　寛大、永瀬　裕朗
- Organizer
  第56回日本てんかん学会学術集会
- Data Source
  KAKENHI-PROJECT-20K17894
[Presentation] 意識障害を呈した小児に対する救急外来簡易脳波の原因疾患別特徴2023
- Author(s)
  山口宏、上田拓耶、老川静香、徳元翔一、西山将広、丸山あずさ、野津寛大、永瀬裕朗
- Organizer
  第56回日本てんかん学会学術集会
- Data Source
  KAKENHI-PROJECT-23K15615
[Presentation] 意識障害を呈した小児に対する救急外来簡易脳波の原因疾患別特徴2023
- Author(s)
  山口宏、上田拓耶、老川静香、徳元翔一、西山将広、丸山あずさ、野津寛大、永瀬裕朗
- Organizer
  第56回日本てんかん学会学術集会
- Data Source
  KAKENHI-PROJECT-20K17894
[Presentation] A comparison of clinical features of acute encephalopathy with biphasic seizures and late reduced diffusion between short and prolonged first seizure duration2020
- Author(s)
  Hiroshi Yamaguchi; Masahiro Nishiyama; Shoichi Tokumoto; Yusuke Ishida; Daisaku Toyoshima; Azusa Maruyama, Kazumoto Iijima; Hiroaki Nagase
- Organizer
  The International Symposium on Pathophysiology of Developmental and Epileptic Encephalopathy 2020
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K17894
[Presentation] けいれん重積型（二相性）急性脳症の初回けいれん時間による臨床像の比較検討2020
- Author(s)
  山口　宏、西山　将広、徳元　翔一、石田　悠介、冨岡　和美、豊嶋　大作、丸山　あずさ、飯島　一誠、永瀬　裕朗
- Organizer
  第62回日本小児神経学会学術集会
- Data Source
  KAKENHI-PROJECT-20K17894

1. 永瀬裕朗

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results
2. 西山将広

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
3. 佐久間啓

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Yamaguchi Hiroshi 山口 宏

Research Projects

Research Products

Co-Researchers

小児急性脳症の網羅的疾患関連遺伝子探索と多角的機能解析による病態解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

持続脳波による急性脳症のNCSの病態と神経傷害機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of the Neurological Damage Mechanism in Non-Convulsive Seizures Utilizing Continuous EEG Data from Emergency DepartmentsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Epidemiology and treatment trends for acute encephalopathy under the impact of SARS-CoV-2 pandemic based on a prospective multicenter consecutive case registry2025

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Elevated cerebrospinal fluid neuronal injury biomarkers within 24?hours of onset in infection-triggered acute encephalopathy compared to complex febrile seizures2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Efficacy and safety of buccal midazolam for seizures outside the hospital: Real-world clinical experience2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Timing of therapeutic interventions against infection-triggered encephalopathy syndrome: a scoping review of the pediatric literature2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Clinical and laboratory characteristics of complex febrile seizures in the acute phase: a case-series study in Japan2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Dravet syndrome and hemorrhagic shock and encephalopathy syndrome associated with an intronic deletion of SCN1A2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Time course of serum cytokine level changes within 72?h after onset in children with acute encephalopathy and febrile seizures2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Early non-convulsive seizures are associated with the development of acute encephalopathy with biphasic seizures and late reduced diffusion2021

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Elevated cytokine, chemokine, and growth and differentiation factor-15 levels in hemorrhagic shock and encephalopathy syndrome: A retrospective observational study2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Prediction of AESD and neurological sequelae in febrile status epilepticus2021

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Thiamylal anaesthetic therapy for febrile refractory status epilepticus in children2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Detailed characteristics of acute encephalopathy with biphasic seizures and late reduced diffusion: 18-year data of a single-center consecutive cohort.2020

Yamaguchi Hiroshi 山口宏