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TASHIRO Kunio  田代 邦雄

ORCIDConnect your ORCID iD *help
Researcher Number 90002154
Other IDs
External Links
Affiliation (based on the past Project Information) *help 2003 – 2004: 北海道医療大学, 心理科学部, 教授
2002: 北海道大学, 大学院・医学研究科, 教授
2000: Hokkaido Univ., Grad.School of Med., Professor, 大学院・医学研究科, 教授
1994 – 1999: 北海道大学, 医学部, 教授
1993 – 1994: HOKKAIDO UNIVERSITY HOSPITAL PROFESSOR, 医学部・附属病院, 教授 … More
1989 – 1992: 北海道大学, 医学部附属病院, 教授
1991: 北海道大学, 医学部, 教授
1988: 北海道大学, 医学部付属病院, 教授 Less
Review Section/Research Field
Principal Investigator
Neurology
Except Principal Investigator
Neurology / Experimental pathology / 公衆衛生学
Keywords
Principal Investigator
多発性硬化症 / HLA / multiple sclerosis / Macrophage Inflammatory Protein (MIP) / RANTES / Proteolipid Protein / 脱髄 / SCA1 / SCA2 / SCA6 … More / 遺伝子 / Myoglobin / CA-III / human leukocyte antigen / attack-related severity / 急性横断性脊髄症 / 神経疫学 / 神経症候学 / 磁気共鳴画像 / オリゴクローナルバンド / 抗カルジオリピン抗体 / オリゴクロ-ナルバンド / 末梢神経 / acute transverse myelopathy / neuroepidemiology / neurosymptomatology / magnetic resonance imaging / oligoclonal band / anticardiolipin antibody / T細胞受容体 / βケモカイン / MIP-1α / MIP-1β / Macrophage inflammatory protein(MIP) / Proteolipid protein / Human leukocyte antigen / T cell / T cell subset / Chemokines / 接着因子 / Multiple Sclerosis / T Cell Receptor / beta -Chemokine / MIP-1 alpha / MIP-1 beta / 脊髄小脳変性症 / ジョセフ病 / CAGリピート / 遺伝子異常 / 遺伝子座 / triplet repeat病 / Spinocerebellar ataxia / Machado-Joseph disease / CAG repeat / Gene mutation / Gene locus / 神経筋疾患 / 筋酵素 / Carbonid anhydrase III / モノクローナル抗体 / 心筋梗塞 / 炭酸脱水水素酵素アイソザイムIII型 / 心筋障害 / Carbonid anhydrase / 炭酸脱水水素アイソザイム1型 / モノクローナク抗体 / ELISA / 測定方法 / 筋疾患マーカー / Garbonic anhydrase III / NEUROMUSCULAR DISEASES / MUSCLE ENZYME / CARBONIC ANHYDRASE-III / MONOCLONALANTIBODY / MYOCARDIAL INFARCTION / MYOGLOBIN / 疫学調査 / 有病率 / 疾患感受性遺伝子 / 多発生硬化症 / 遺伝子多型 / TRAIL / CTLA-4 / 視神経脊髄型 / osteopontin / ケモカイン / 髄液 / サイトカイン / MBP反応性T細胞 / 免疫 / 中枢神経 / epidemiological research / prevalence / susceptibility gene … More
Except Principal Investigator
危険要因 / ライフスタイル / パーキンソン病 / 筋萎縮性側索硬化症 / 運動ニューロン疾患 / 疫学 / 遺伝子 / 脊髄小脳変性症 / spinocerebellar ataxia / glycation / oxidative stress / ALS / motor neuron / 分子生物学 / 時間分解顕微蛍光法 / ピコ秒パルスレ-ザ- / ヘキサゴナル相 / ジアシルグリセロ-ル / リポソ-ム / 蛍光寿命 / パ-キンソン病 / ケ-ス・コントロ-ル研究 / ケース・コントロール研究 / 老年痴呆 / ケース・コントロール法 / 素因遺伝子 / 環境・遺伝交互作用 / 遺伝的素因 / 遺伝子環境相関 / 神経変性疾患 / 発生率 / 趨勢変動 / ゴンペルツ分析 / 競合死因 / 遺伝子性脊髄小脳変性症 / 連鎖解析 / CAG反復配列 / 創始者効果 / 診断基準 / 電離放射線 / 原爆実験 / 神経筋症患 / 遺伝子変異 / 遺伝子治療 / ウイルスベクター / 神経筋疾患 / 第17染色体 / cDNA / 反復経頭蓋磁気刺激 / 中枢神経疾患 / うつ症状 / 8の字コイル / 大うつ病 / 前前頭野 / Choline acetyltransferase / 外的因子 / ポリオ ウイルス / 水銀 / ChAT / MOTOR NEURON DISEASE / AMYOTROPHIC LATERAL SCLEROSIS / CHOLINE ACETYLTRANSFERASE / EXTERNAL FACTORS / POLIO VIRUS / MERCURY / 痙性対麻痺 / 遺伝子異常 / 遺伝子座 / spastic paraplegia / gene mutation / gene locus / advanced glycation end products(AGE) / AGE / advanced glycation end products (AGES) / 発症機序 / 神経難病 / 多系統萎縮症 / spinocerebellar degeneration / molecular mechanism / neurodegenerative disorder / 最終糖化産物 / 脊髄運動ニューロン / カルボキシメチルリジン / 運動ニューロン / ユビキチン・プロテアソーム系 / 脊髄器官培養 / Amyotrophic lateral sclerosis / Advanced glycation end product / Spinal motor neuron / Carboxymethyl lysine / 脳卒中登録 / 血管性痴呆 / 予防 / 地域保健 / 高血圧 / 老人 / 脳卒中登録予防 / 地域医療ケア / コホ-ト研究 / 画像診断 / コホート研究 / Stroke Registry / Vascular Dementias / Epidemiology / Risk Factor / Prevention / Regional Health Care / Hypertention / Senile Less
  • Research Projects

    (21 results)
  • Research Products

    (15 results)
  • Co-Researchers

    (26 People)
  •  Investigation of clinical and immunological heterogeneity of multiple sclerosis, and its moleculogenetical backgroundPrincipal Investigator

    • Principal Investigator
      TASHIRO Kunio
    • Project Period (FY)
      2002 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Neurology
    • Research Institution
      Health Sciences University of Hokkaido
      Hokkaido University
  •  Causative gene mutation and molecular mechanism in spinooerebellar degeneration

    • Principal Investigator
      SASAKI Hidenao
    • Project Period (FY)
      2002 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Neurology
    • Research Institution
      HOKKAIDO UNIVERSITY
  •  The Association of AGEs (Advanced Glycation End product) and oxoaldehydes with spinal motor neuronal death

    • Principal Investigator
      KIKUCHI Seiji
    • Project Period (FY)
      2002 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Neurology
    • Research Institution
      HOKKAIDO UNIVERSITY
  •  反復経頭蓋磁気刺激法の臨床応用への安全性の検討

    • Principal Investigator
      眞野 行生
    • Project Period (FY)
      1999
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Neurology
    • Research Institution
      Hokkaido University
  •  Glycation and AGEs in motor neurons - synergism with oxidative stress -

    • Principal Investigator
      KIKUCHI Seiji
    • Project Period (FY)
      1998 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Neurology
    • Research Institution
      HOKKAIDO UNIVERSITY
  •  神経・筋症患の遺伝子治療に関する基礎的研究

    • Principal Investigator
      MORIWAKA Fumio
    • Project Period (FY)
      1997 – 1998
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Neurology
    • Research Institution
      Hokkaido University
  •  Molecular genetic studies of dominantly inherited spastic paraplegia

    • Principal Investigator
      SASAKI Hidenao
    • Project Period (FY)
      1997 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (B).
    • Research Field
      Neurology
    • Research Institution
      Hokkaido University
  •  遺伝子・環境交互作用の分析によるパーキンソン病の易羅病性の解明

    • Principal Investigator
      近藤 喜代太郎
    • Project Period (FY)
      1996
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Hokkaido University
  •  THE DIAGNOSTIC STRATEGIES AND THE CLINICAL APPLICATION OF CARBONIC ANHYDRASE-III IN THE NEUROMUSCULAR DISEASESPrincipal Investigator

    • Principal Investigator
      TASHIRO Kunio
    • Project Period (FY)
      1996 – 1998
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Neurology
    • Research Institution
      HOKKAIDO UNIVERSITY
  •  遺伝子・環境交互作用の分析によるパーキンソン病の易罹病性の解明

    • Principal Investigator
      近藤 喜代太郎
    • Project Period (FY)
      1995
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Hokkaido University
  •  遺伝性脊髄小脳変性症における三塩基反復配列の探索

    • Principal Investigator
      WAKISAKA Akemi
    • Project Period (FY)
      1995
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      Experimental pathology
    • Research Institution
      Hokkaido University
  •  MOLECULAR GENETIC STUDY OF HEREDITARY SPINOCEREBELLAR ATAXIAPrincipal Investigator

    • Principal Investigator
      TASHIRO Kunio
    • Project Period (FY)
      1995 – 1997
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Neurology
    • Research Institution
      HOKKAIDO UNIVERSITY
  •  遺伝子・環境交互作用の分析によるパーキンソン病の易罹病性の解明

    • Principal Investigator
      近藤 喜代太郎
    • Project Period (FY)
      1994
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Hokkaido University
  •  パーキンソン病の危険要因に関する分析疫学的研究

    • Principal Investigator
      近藤 喜代太郎
    • Project Period (FY)
      1993
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Hokkaido University
  •  Research in the pathogenesis of multiple sclerosis. Analysis of characteristics of T cell receptor.Principal Investigator

    • Principal Investigator
      TASHIRO Kumio
    • Project Period (FY)
      1993 – 1994
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      Neurology
    • Research Institution
      HOKKAIDO UNIVERSITY
  •  パーキンソン病の危険要因に関する分析疫学的研究

    • Principal Investigator
      近藤 喜代太郎
    • Project Period (FY)
      1992
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Hokkaido University
  •  RESEARCH IN THE PATHOGENESIS OF MOTOR NEURON DISEASES.ANALYSIS OF CHOLINE ACETYLTRANSFERASE GENE EXPRESSION IN SPINAL MOTOR NEURON.

    • Principal Investigator
      MORIWAKA Fumio
    • Project Period (FY)
      1992 – 1993
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Neurology
    • Research Institution
      HOKKAIDO UNIVERSITY
  •  時間分解顕微蛍光法によるトランスミッタ-放出機構の解析

    • Principal Investigator
      石俊 輝雄
    • Project Period (FY)
      1991
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Hokkaido University
  •  パ-キンソン病の危険要因に関する分析疫学的研究

    • Principal Investigator
      KONDO Kiyotaro
    • Project Period (FY)
      1991
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Hokkaido University
  •  Symptomatological and epidemiological studies on multiple sclerosis in HokkaidoPrincipal Investigator

    • Principal Investigator
      TASHIRO Kunio
    • Project Period (FY)
      1990 – 1992
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Neurology
    • Research Institution
      Hokkaido University
  •  Prevention of Vascular Dementias with Stroke Registry

    • Principal Investigator
      KONDO Kiyotaro
    • Project Period (FY)
      1988 – 1989
    • Research Category
      Grant-in-Aid for Co-operative Research (A)
    • Research Field
      公衆衛生学
    • Research Institution
      Hokkaido University

All 2005 2004 2003 2002

All Journal Article Book

  • [Book] AGEs研究の最前線2004

    • Author(s)
      田代 淳
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14570574
  • [Journal Article] CSF pleocytosis and expansion of spinal lesions in Japanese MS : A special reference to the new diagnostic criteria2005

    • Author(s)
      Fukazawa T, Kikuchi S, Tashiro K, et al.
    • Journal Title

      Journal of Neurology 252(Published online March 6,1-)

    • Data Source
      KAKENHI-PROJECT-14370201
  • [Journal Article] Interferon beta-1b is effective in Japanese RRMS patients, A randomized, multicenter study.2005

    • Author(s)
      Saida T, Tashiro K., et al.
    • Journal Title

      Neurology 64

      Pages: 621-629

    • Data Source
      KAKENHI-PROJECT-14370201
  • [Journal Article] Ibudilast, a non-selective phosphodiesterase inhibitor, regulates Th1/Th2 balance and NKT cell subset in MS2004

    • Author(s)
      Feng J, Fukaura H, Kikuchi S, Tashiro k, et al.
    • Journal Title

      Multiple Sclerosis 10

      Pages: 494-498

    • Data Source
      KAKENHI-PROJECT-14370201
  • [Journal Article] Attack-related severity : Akey factor in understanding the spectrum of idiopathic inflammatory demyelinating disorders2004

    • Author(s)
      Fukazawa T, Kikuchi S, Niino M, Tashiro K., et al.
    • Journal Title

      Journal of the Neurological Sciences 225

      Pages: 71-78

    • Data Source
      KAKENHI-PROJECT-14370201
  • [Journal Article] 日本における多発性硬化症疫学調査の意義2004

    • Author(s)
      田代邦雄
    • Journal Title

      神経内科 61

      Pages: 411-414

    • Data Source
      KAKENHI-PROJECT-14370201
  • [Journal Article] Platelet-activating factor acethylhydrolase gene polymorphism and its activity in Japanese patients with multiple sclerosis2004

    • Author(s)
      Osoegawa M, Niino M, Kikuchi S, Tashiro K, et al.
    • Journal Title

      Journal of Neuroimmunology 150

      Pages: 150-156

    • Data Source
      KAKENHI-PROJECT-14370201
  • [Journal Article] Brefeldin A-induced neurotoxicity in cultured.spinal cord neurons.2003

    • Author(s)
      Kikuchi S, Shinpo K, Tsuji S, Yabe I, Niino M, Tashiro K
    • Journal Title

      J Neurosci Res 71

      Pages: 591-599

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14570574
  • [Journal Article] Glycation -a sweet tempter for neuronal death2003

    • Author(s)
      Kikuchi S, Shinpo K, Takeuchi M, Yamagishi S, Makita Z, Sasaki N, Tashiro K
    • Journal Title

      Brain Research Reviews 41

      Pages: 306-323

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14570574
  • [Journal Article] Effect of proteasome inhibitor on cultured mesencephalic dopaminergic neurons2003

    • Author(s)
      Kikkuchi S, Shinpo K, Tsuji S, Masayoshi T, Yamagishi S, Makita Z, Niino M, Yabe I, Tashiro K
    • Journal Title

      Brain Res 964

      Pages: 228-236

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14570574
  • [Journal Article] Prostaglandin E1 protects cultured spinal neurons against the effects of nitiric oxide toxicity2002

    • Author(s)
      Kikuchi S, Shinpo K, Niino M, Tsuji S, Iwabuchi K, Onoe K, Tashiro K
    • Journal Title

      Neuropharmachology 42

      Pages: 714-723

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14570574
  • [Journal Article] Detection of N^E-(carboxymethyl) lysine (CML) and non-CML advanced glycation end-products in the anterior horn of amyotrophic lateral sclerosis spinal cord2002

    • Author(s)
      Kikuchi S, Shinpo K, Ogata A, Tsuji S, Takeuchi M, Makita Z, Tashiro K
    • Journal Title

      ALS and other motor neuron disorders 3

      Pages: 63-66

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14570574
  • [Journal Article] Progress in the field of neurology in the last 100 years : Triplet repeat disease.2002

    • Author(s)
      Tashiro K
    • Journal Title

      Nippon Natka Gakkai Zasshi 91

      Pages: 2263-2267

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14370202
  • [Journal Article] Effect of Geranylgeranylaceton on Cellular Damage Induced by Proteasome Inhibition in Culutured Spinal Neurons2002

    • Author(s)
      Kikuchi S, Shinpo K, Takeuchi M, Tsuji S, Yabe I, Niino M, Tashiro K
    • Journal Title

      Journal of Neuroscience Research 69

      Pages: 373-381

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14570574
  • [Journal Article] 新しい遺伝子異常・トリプレットリピート病2002

    • Author(s)
      田代邦雄
    • Journal Title

      日本内科学会雑誌 内科-100年のあゆみ(神経) 特集

      Pages: 2263-2267

    • NAID

      10010929451

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14370202
  • 1.  MORIWAKA Fumio (30142722)
    # of Collaborated Projects: 11 results
    # of Collaborated Products: 0 results
  • 2.  KONDO Kiyotaro (80018366)
    # of Collaborated Projects: 7 results
    # of Collaborated Products: 0 results
  • 3.  志渡 晃一 (20206098)
    # of Collaborated Projects: 6 results
    # of Collaborated Products: 0 results
  • 4.  KIKUCHI Seiji (10271660)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 9 results
  • 5.  WAKISAKA Akemi (90113646)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 6.  SASAKI Hidenao (80281806)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 7.  新野 峰久 (80180561)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 8.  羽田 明 (00244541)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 9.  YABE Ichiro (60372273)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  TANAKA Heizou (70047215)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  NAGAI Masashi (90124403)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  THOGI Hideo (90155490)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  石俊 輝雄 (60001872)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 14.  荒磯 恒久 (30151145)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 15.  西平 順 (30189302)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 16.  高桑 雄一 (40113740)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 17.  池田 仁 (20232192)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 18.  吉木 敬 (60220612)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 19.  眞野 行生 (20145882)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 20.  辻 貞俊 (30117171)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 21.  中馬 孝容 (70281805)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 22.  松浦 亨 (90271676)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 23.  HIBI Nozomi
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 24.  TSUKADA Hiroshi
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 25.  SUZUKI Kazuo
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 26.  杉村 巌
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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